The biokinetics of ruthenium in the human body.

The International Commission on Radiological Protection (ICRP) is updating its biokinetic and dosimetric models for workers and subsequently will revisit its models for members of the public. This paper summarises the biokinetic database for ruthenium and proposes a new biokinetic model for systemic ruthenium. In contrast to the ICRP's current model, the proposed model depicts recycling of ruthenium between tissues and blood and a non-uniform distribution of systemic ruthenium. The paper also points out inconsistencies between the ICRP's respiratory model for RuO(4) vapour and reported data, and inconsistencies between the ICRP's default gastrointestinal (GI) uptake value and data for some forms of ruthenium. Dosimetric implications of the proposed systemic model and the findings for inhaled RuO(4) vapour and GI uptake of ruthenium are examined.

Accumulation history of radionuclides in the lichen Stereocaulon vesuvianum from Mt. Vesuvius (south Italy).

The fruticose lichen Stereocaulon vesuvianum, growing on the slopes of Mt. Vesuvius (south Italy), was used as a biomonitor of 134Cs, 137Cs, 103Ru and 106Ru derived from the April 26 1986 Chernobyl nuclear reactor accident. Samples were taken at five different quotes (370, 490, 580, 780 and 960 m a.s.l.) and four successive dates (October 1986, December 1986, October 1987 and May 1999). At the first sampling, the concentrations (as Bq kg(-1) dry weight) ranged between 460 and 1020 for 134Cs, 1330 and 2500 for 137Cs, 90 and 200 for 103Ru and 360 and 710 for 106Ru, values generally lower in respect to those measured in soil and higher plants. Of the total 137Cs measured only 14% was due to 1950s and 1960s nuclear weapons tests fallout. Highest average activities of all nuclides were observed at the quote of 960 m and significant correlation (0.7

Stable tracer investigations in humans for assessing the biokinetics of ruthenium and zirconium radionuclides.

The interest in the biokinetics of ruthenium and zirconium in humans is justified by the potential radiological risk represented by their radionuclides. Only a few data related to the biokinetics of ruthenium and zirconium in humans are available and, accordingly, the biokinetic models currently recommended by the ICRP for these elements are mainly based on data from animal experiments. The use of stable isotopes as tracers, coupled with a proper analytical technique (nuclear activation analysis with protons) for their determination in biological samples, represents an ethically acceptable methodology for biokinetic investigations, being free from any radiation risk for the volunteer subjects. In this work, the results obtained in eight biokinetic investigations for ruthenium, conducted on a total of three healthy volunteers, and six for zirconium, performed on a total of three subjects, are presented and compared to the predictions of the ICRP models.

Kinetics of systemic ruthenium in human blood using a stable tracer.

The biokinetics of ruthenium after oral and intravenous administration has been investigated in two human subjects using the stable isotope 101Ru as a tracer. Tracer concentrations in blood plasma have been determined using activation analysis with protons. The results presented here prove that the stable tracer technique is a valuable tool for obtaining relevant information about the biokinetics of ruthenium in humans. From these pilot studies, it may be argued that the clearance of systemic ruthenium from plasma is significantly slower than the predictions of the biokinetic model currently recommended by the International Commission on Radiological Protection (ICRP). The experimental data for the orally administered tracer, which reflect the gastrointestinal absorption process, differ from the curve derived from the ICRP model, suggesting that the uptake into the systemic circulation may be lower than predicted. On the basis of these preliminary data, investigations on a larger number of subjects with improvements in the experimental design are scheduled.

[The effect of algisorb on the level of the accumulation of zirconium, ruthenium, iodine and cesium radioactive isotopes in the body of rats]. / Vliianie al'gisorba na uroven' nakopleniia radioaktivnykh izotopov tsirkoniia, ruteniia, ioda i tseziia v organizme krys.

The sorption effect of Algisorbum has been studied in rats following single and multiple intragastric administration. Algisorbum doses of 250-2000 mg/kg decrease the absorption of 106Ru and 95Zr by 50%, that of 137Cs by 15% and have no effect on 131I absorption. Application of a complex of agents to protect the body from nuclear fission products is discussed.

Placental transfer of ruthenium in rat and guinea-pig.

Ruthenium-106 in citrate solution was administered intravenously to rat at different stages of pregnancy and to guinea-pig either before conception or in late pregnancy. The results for rat showed that retention in the embryo/foetus measured at 3-5 days after administration increased from about 0.0002% of injected activity per embryo/foetus on day 12 of gestation to about 0.05% at birth. The relative concentrations of 106Ru in embryo/foetus and mother (Cf/Cm ratio) were about 0.1 in each case. Concentrations in the yolk sac on day 12 were about 1% g-1 compared with 0.01% g-1 in the foetus. Retention in the guinea-pig foetus in late gestation at 7 days after administration (days 50-57) was about 0.2% injected activity per foetus, corresponding to a Cf/Cm = 0.2. Retention in each foetoplacental unit was 2% of injected 106Ru with 50% in the yolk sac, 35% in the placenta and 10% in the foetus. For administration 4 weeks prior to conception, the level of 106Ru retained in the foetus on day 57 of gestation was two orders of magnitude lower than after short-term administration, with a Cf/Cm about 0.004.

Behavior of neutron-activated uranium dioxide dust particles in the gastrointestinal tract of the rat.

The behavior of neutron-irradiated, simulated Chernobyl UO2 particles containing 141Ce, 144Ce, 95Zr, 95Nb, and 103Ru in the gastrointestinal tract was investigated to obtain basic information for dosimetric and risk analyses of nuclear accidents. After the UO2 particles were administered to rats intragastrically, the distribution and retention of specific radionuclides were studied by using whole-body autoradiography and gamma-spectrometric analysis of tissues. None of the radionuclides were detected in liver, kidney, muscle, bone, brain, blood, and urine. Approximately 98% of the total administered radioactivity was excreted in feces within 3 days. A two times greater intestinal retention (about 6%) of 95Nb than for the other radionuclides was observed 1 day after administration. The results indicate that this kind of relatively insoluble particulate material is not absorbed or retained significantly in the epithelial cells of the intestinal wall. Fallout particles containing high-energy beta sources, 106Ru and 144Ce, result in a very high radiation dose (up to several Gy/day) in the vicinity of a hot particle. Niobium-95 with low average beta energy (0.043 MeV (100%)) does not increase the total dose to the GI tract significantly despite its longer retention in the intestine. Evaluation of the biological effects of these particles in the GI tract by using a dosimetric model based on uniform distribution of activity may be misleading.

[Improved diagnosis using deuterated radiopharmaceuticals?--A comparison of the brain affinity of amphetamine analogs]. / Verbesserte Diagnostik durch deuterierte Radiopharmaka?--Vergleich der Gehirn-Affinität von Amphetamin-Analoga.

Ruthenocene amphetamine analogues have the same brain uptake as iodo-labelled amphetamines. This paper compares the organ-distribution of 103Ru labelled ruthenocene- or ferrocene-amphetamine analogues in mice and rats with the same amphetamine in which H-atoms were partly substituted by D-atoms. The uptake in the brain is increased up to 180-200% for deuterium substituted compounds. The pattern of excreted metabolites leads to the conclusion that the deuterated amphetamines are more slowly metabolised than normal (H) compounds.