Assuntos
Transplante de Medula Óssea/imunologia , Moléculas de Adesão Celular/sangue , Doença Enxerto-Hospedeiro/imunologia , Linfócitos T/imunologia , Doença Aguda , Anemia Aplástica/terapia , Antígenos CD28/sangue , Doença Crônica , Seguimentos , Rejeição de Enxerto/epidemiologia , Rejeição de Enxerto/imunologia , Humanos , Receptores de Hialuronatos/sangue , Integrina alfa4beta1 , Integrinas/sangue , Molécula 1 de Adesão Intercelular/sangue , Leucemia/terapia , Mieloma Múltiplo/terapia , Síndromes Mielodisplásicas/terapia , Receptores de Fibronectina/sangue , Receptores de Retorno de Linfócitos/sangue , Fatores de Tempo , Transplante HomólogoRESUMO
Kaposi's sarcoma (KS) is an angioproliferative disease characterized by proliferation of neoplastic cells (spindle cells) mixed with endothelial and inflammatory cells. In this study we evaluated the role of the adhesive glycoprotein, fibronectin (FN) and its receptor alpha(5)beta(1) (FNR), and the proto-oncogene bcl-2, an anti-apoptotic protein. Significantly decreased serum levels of FN were noted in HIV-1-infected patients with KS, whereas serum levels of FNR were significantly increased in the same patients. Furthermore, increased FNR expression was observed on CD4 cells from KS patients. Serum levels of bcl-2 protein were significantly decreased in asymptomatic seropositive patients, whereas HIV-1-infected patients with KS showed increased serum levels of bcl-2. These results provide further information about interaction between integrins and the extracellular matrix and bcl-2 protein that can support cell survival either of neoplastic cells or endothelial and inflammatory cells.