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1.
Urology ; 157: 274-279, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34274392

RESUMO

OBJECTIVE: To examine the occurrence of 30-day mortality, and other procedure related morbidities in cohorts of patient receiving neuraxial anesthesia (NAX) or general anesthesia (GA) in the setting of transurethral resection of the prostate (TURP). Historically, NAX has been recommended for patients undergoing TURP permitting monitoring of consciousness and early diagnosis of absorption-related hyponatremia. We aim to analyze a broader comparison of mortality and other associated morbidities regarding the form of anesthesia utilized. METHODS: The National Surgical Quality Improvement Program (NSQIP) database was accessed and queried from January 2010 to December 2016 for TURP. 28,486 TURP cases were identified and further stratified by the type anesthesia administration, NAX 7,261 and GA 21,225. Chi-square analyses and Kaplan-Meier tests were performed for univariate comparisons. Using propensity score, data were optimally (1:1) matched to account for potential confounding variables. Outcomes were then compared for NAX vs. GA with a primary endpoint of 30-day mortality, followed by secondary endpoint of adverse outcomes reported per NSQIP. RESULTS: Prior to matching, 30-day mortality was found to be 0.4% in the NAX cohort and 0.7% GA. 12,180 patients equally matched between the 2 groups. NAX was found to be superior to GA in terms of 30-day survival benefit (OR 0.55, 95% CI 0.33 -0.92, P <0.05), sepsis (OR 0.60, 95% CI 0.50 -0.73, P <0.001), and return to operating room (OR 0.76, 95% CI 0.60 -0.98, P <0.05) when comparing matched cohorts. NAX was associated with lower incidence of overall adverse clinical outcomes 12.4% vs 13.7% (P = 0.036). CONCLUSION: NAX was found to have statistically relevant advantage for 30-day postoperative outcomes when compared to GA for TURP based on NSQIP database reporting.


Assuntos
Anestesia Epidural , Anestesia Geral , Ressecção Transuretral da Próstata/mortalidade , Humanos , Masculino , Estudos Retrospectivos , Espaço Subaracnóideo , Fatores de Tempo , Resultado do Tratamento
2.
Urol Oncol ; 36(12): 527.e21-527.e28, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30442538

RESUMO

OBJECTIVES: To examine oncological, surgical, and functional outcomes of radical prostatectomy (RP) in patients with history of transurethral resection of the prostate (TUR-P). MATERIALS AND METHODS: Retrospective analysis of 18,681 RP-patients including 470 patients with previous TUR-P at a single institution (2002-2015). Kaplan-Meier as well as multivariable Cox and logistic regression analyses compared surgical, oncological, and functional outcomes between TUR-P and non-TUR-P patients after propensity score matching (nearest neighbor in a 1:3 fashion). RESULTS: After propensity score adjustment, pathological and surgical results were similar between both groups. Specifically, rates of positive surgical margins and nerve-sparing (NS) procedure did not differ between groups (positive surgical margins: 18.5% vs. 17.2%, P = 0.7; nerve-sparing: 89.4% vs. 91.6%, P = 0.5). In addition, there was no difference in mean operating room time (185 vs. 184 minutes, P = 0.6), blood loss (710 vs. 666 ml, P = 0.1), and catheterization time (12 days, P = 0.3). In multivariable analyses, TUR-P patients did not exhibit higher risk of biochemical recurrence, metastatic progression, or mortality (all P > 0.05). However, TUR-P patients exhibited higher risk for urinary incontinence at third month (OR: 1.47; 95% confidence interval [CI] 1.01-2.12, P = 0.04) and first year (OR: 2.06; 95% CI 1.23-3.42, P = 0.006) and worse 1-year erectile function recovery (OR: 0.48; 95% CI 0.27-0.86, P = 0.02). CONCLUSIONS: This large series of TUR-P RP patients demonstrated that RP could be safely performed in patients with history of TUR-P without compromising oncological results. However, functional outcomes were worse for patients with previous TUR-P.


Assuntos
Biomarcadores Tumorais/metabolismo , Complicações Pós-Operatórias , Prostatectomia/mortalidade , Neoplasias da Próstata/mortalidade , Neoplasias da Próstata/patologia , Ressecção Transuretral da Próstata/mortalidade , Incontinência Urinária , Idoso , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias da Próstata/metabolismo , Neoplasias da Próstata/cirurgia , Estudos Retrospectivos , Taxa de Sobrevida , Resultado do Tratamento
3.
Prog Urol ; 27(5): 312-318, 2017 Apr.
Artigo em Francês | MEDLINE | ID: mdl-28377079

RESUMO

INTRODUCTION: Monopolar transurethral resection of the prostate is one of standard surgical treatment of benign prostatic hyperplasia. The objective of this study was to evaluate early postoperative complications in patients aged 75 years old and more using a standardized classification. MATERIAL AND METHODS: We included all patients aged at least 75 on the day of surgery between 1 January 2008 and 31 December 2013. The reporting of complications was carried from the Clavien-Dindo classification. RESULTS: One hundred and seventy-six patients were included in this study. A total of 47.2% of patients experienced at least one complication. The majority of patients (79.5%) had complications grade 1 or 2 according to Clavien-Dindo classification. One patient died postoperatively at day 27. Most complications were urological (55%). A high Charlson score and low plasma hemoglobin levels have been identified as a risk factor for complications. CONCLUSION: Monopolar transurethral resection of the prostate is followed by significant morbidity in older patients, higher than in the general population. LEVEL OF EVIDENCE: 4.


Assuntos
Envelhecimento , Pacientes Internados/estatística & dados numéricos , Hiperplasia Prostática/epidemiologia , Hiperplasia Prostática/cirurgia , Ressecção Transuretral da Próstata/mortalidade , Idoso , Idoso de 80 Anos ou mais , França/epidemiologia , Humanos , Incidência , Masculino , Hiperplasia Prostática/mortalidade , Estudos Retrospectivos , Fatores de Risco , Análise de Sobrevida , Ressecção Transuretral da Próstata/efeitos adversos , Resultado do Tratamento
4.
Can J Urol ; 22 Suppl 1: 67-74, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26497346

RESUMO

INTRODUCTION: Benign prostatic hyperplasia (BPH) is an obligate disorder of the aging male prostate with close associations to other metabolic conditions of aging including obesity. Clinical manifestations of this chronic disorder increase as men age suggesting that a growing number of older men will require intervention for progressive voiding symptoms or bladder dysfunction. MATERIALS AND METHODS: The Prostatic Urethral Lift (PUL) procedure represents a new endoscopic approach in which small permanent intraprostatic implants are positioned to correct bladder outlet obstruction without tissue destruction. An overview of the treatment modality, review of recent literature, and analysis of data in the context of cost considerations is presented. RESULTS: The mean symptom score improvement of the prospective, sham controlled, pivotal trial was 11 points, 88% greater than sham controls. Multiple studies have confirmed symptom score improvement of at least 52%. Durability has been established out to 3 years. A randomized comparison between PUL and transurethral resection of the prostate (TURP) established PUL as superior to TURP in terms of a composite BPH6 endpoint which incorporated symptom relief, quality of recovery, erectile function preservation, ejaculatory function preservation, continence preservation, and safety. The National Institute for Health and Care Excellence of the United Kingdom conducted an analysis that found PUL is less costly than TURP. Earlier management with PUL may even reduce overall cost for those patients managed with medication. CONCLUSION: Current reports have demonstrated rapid voiding symptom improvement with a low risk of adverse events suggesting that this procedure represents a safe and cost effective new paradigm for the early therapy for BPH/ LUTS.


Assuntos
Endoscopia/métodos , Sintomas do Trato Urinário Inferior/cirurgia , Hiperplasia Prostática/cirurgia , Qualidade de Vida , Uretra/cirurgia , Obstrução do Colo da Bexiga Urinária/cirurgia , Idoso , Idoso de 80 Anos ou mais , Envelhecimento/fisiologia , Idoso Fragilizado , Humanos , Sintomas do Trato Urinário Inferior/etiologia , Sintomas do Trato Urinário Inferior/psicologia , Masculino , Segurança do Paciente , Prognóstico , Hiperplasia Prostática/complicações , Hiperplasia Prostática/mortalidade , Hiperplasia Prostática/psicologia , Próteses e Implantes , Medição de Risco , Índice de Gravidade de Doença , Taxa de Sobrevida , Ressecção Transuretral da Próstata/métodos , Ressecção Transuretral da Próstata/mortalidade , Resultado do Tratamento , Obstrução do Colo da Bexiga Urinária/etiologia , Obstrução do Colo da Bexiga Urinária/mortalidade , Micção/fisiologia
5.
Vopr Onkol ; 61(6): 982-5, 2015.
Artigo em Russo | MEDLINE | ID: mdl-26995992

RESUMO

The study included 164 prostate cancer patients with a history of acute or chronic urinary retention. Conservative therapy or transurethral resection of the prostate were carried out to all patients as treatment for urinary retention. There was studied an influence of transurethral resection of the prostate on the survival of patients with prostate cancer and development of radiation complications following radiotherapy. Overall survival of prostate cancer patients who underwent transurethral resection of the prostate was significantly higher than in patients who had only conservative therapy as a treatment of dysuria. The frequency of radiation complications was lower in patients who had transurethral resection of the prostate prior radiation therapy.


Assuntos
Neoplasias da Próstata/mortalidade , Neoplasias da Próstata/cirurgia , Ressecção Transuretral da Próstata , Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias da Próstata/radioterapia , Neoplasias da Próstata/terapia , Radioterapia/efeitos adversos , Radioterapia Adjuvante/efeitos adversos , Análise de Sobrevida , Ressecção Transuretral da Próstata/mortalidade
6.
J Endourol ; 28(7): 831-40, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24517323

RESUMO

BACKGROUND AND PURPOSE: With the aging population, it is becoming increasingly important to identify patients at risk for postsurgical complications who might be more suited for conservative treatment. We sought to identify predictors of morbidity after surgical treatment of benign prostatic hyperplasia (BPH) using a large national contemporary population-based cohort. METHODS: Relying on the American College of Surgeons National Surgical-Quality Improvement Program (ACS-NSQIP; 2006-2011) database, we evaluated outcomes after transurethral resection of the prostate (TURP), laser vaporization of the prostate (LVP), and laser enucleation of the prostate (LEP). Outcomes included blood-transfusion rates, length of stay, complications, reintervention rates, and perioperative mortality. Multivariable logistic-regression analysis evaluated the predictors of perioperative morbidity and mortality. RESULTS: Overall, 4794 (65.2%), 2439 (33.1%), and 126 (1.7%) patients underwent TURP, LVP, and LEP, respectively. No significant difference in overall complications (P=0.3) or perioperative mortality (P=0.5) between the three surgical groups was found. LVP was found to be associated with decreased blood transfusions (odds ratio [OR]=0.21; P=0.001), length of stay (OR=0.12; P<0.001) and reintervention rates (OR=0.63; P=0.02). LEP was found to be associated with decreased prolonged length of stay (OR=0.35; P=0.01). Men with advanced age at surgery and non-Caucasians were at increased risk of morbidity and mortality. In contrast, normal preoperative albumin and higher preoperative hematocrit (>30%) levels were the only predictors of lower overall complications and perioperative mortality. CONCLUSIONS: All three surgical modalities for BPH management were found to be safe. Advanced age and non-Caucasian race were independent predictors of adverse outcomes after BPH surgery. In patients with these attributes, conservative treatment might be a reasonable alternative. Also, preoperative hematocrit and albumin levels represent reliable predictors of adverse outcomes, suggesting that these markers should be evaluated before BPH surgery.


Assuntos
Bases de Dados Factuais/estatística & dados numéricos , Terapia a Laser/efeitos adversos , Hiperplasia Prostática/cirurgia , Melhoria de Qualidade , Ressecção Transuretral da Próstata/efeitos adversos , Fatores Etários , Idoso , Transfusão de Sangue/estatística & dados numéricos , Hematócrito , Humanos , Terapia a Laser/mortalidade , Tempo de Internação , Masculino , Morbidade , Razão de Chances , Hiperplasia Prostática/sangue , Hiperplasia Prostática/etnologia , Hiperplasia Prostática/mortalidade , Análise de Regressão , Reoperação/estatística & dados numéricos , Albumina Sérica/análise , Sociedades Médicas/estatística & dados numéricos , Ressecção Transuretral da Próstata/mortalidade , Estados Unidos
7.
Aging Male ; 16(4): 191-4, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23957825

RESUMO

INTRODUCTION: To evaluate surgical risk and post-operative quality of living status in patients over 85 years of age after transurethral vaporization resection of the prostate (TUVRP). METHODS: Sixty patients over 85 years of age underwent TUVRP were compared with 228 patients less than the age of 80 years. Group A was 60 patients greater than 85 years of age, Group B was 137 patients from 71 to 79 years of age, and Group C was 91 patients from 60 to 70 years of age. RESULTS: In Group A, pre-operative ASA grade was higher than the other two groups, compared with Group C, p < 0.01. Operating time was 40.03 ± 18.90 min, compared in the three groups, p > 0.05. Follow-up was obtained in 49 (81.67%) patients; of them 10 patients were deaths with a survival time of 22.90 ± 11.14 months. In the 39 survivors, post-operative IPSS score was 11.17 ± 6.9, compared with Group B, p > 0.05 and Group C, p < 0.01. Quality of Life (QOL) index was 1.11 ± 0.80, compared with Group B, p < 0.001 and Group C, p < 0.01. Barthel Index score in 16 patients was >60 and the score was 82.81 ± 8.56 pre-operatively. The patients with >60 were increased to 19 cases and the score was improved to 90.93 ± 7.58 (p < 0.001) in follow-up. CONCLUSION: Surgical risk in patients over 85 years of age was higher than patients less than the age of 80 years. A safety TUVRP could improve their voiding function and activities of daily living.


Assuntos
Atividades Cotidianas , Próstata , Hiperplasia Prostática/cirurgia , Qualidade de Vida , Ressecção Transuretral da Próstata , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , China , Humanos , Masculino , Pessoa de Meia-Idade , Duração da Cirurgia , Tamanho do Órgão , Avaliação de Resultados da Assistência ao Paciente , Período Pós-Operatório , Próstata/patologia , Próstata/cirurgia , Hiperplasia Prostática/diagnóstico , Projetos de Pesquisa , Medição de Risco , Análise de Sobrevida , Ressecção Transuretral da Próstata/métodos , Ressecção Transuretral da Próstata/mortalidade , Ressecção Transuretral da Próstata/psicologia
8.
Urologiia ; (5): 92-5, 2012.
Artigo em Russo | MEDLINE | ID: mdl-23342624

RESUMO

The article presents a method of organ-sparing radical transvesical extraurethral adenomectomy in which adenomatous prostate tissue are removed as individual fragments from semi-oval or wedge-shaped incision of the bladder neck and initial part of the prostatic urethra. Preservation ofprostatic urethra and its vascular plexus provides minimal intraoperative blood loss and less traumatic treatment. Correction of vesico-urethral segment is carried out with full preservation ofthe closing apparatus of the bladder. More than 2,000 patients were followed-up for postoperative immediate and long-term results. Mortality after this type of intervention was 0.89%. Urinary incontinence and urethral stricture were not reported in any patients.


Assuntos
Hiperplasia Prostática/cirurgia , Ressecção Transuretral da Próstata/métodos , Idoso , Perda Sanguínea Cirúrgica/prevenção & controle , Seguimentos , Humanos , Masculino , Hiperplasia Prostática/mortalidade , Hiperplasia Prostática/patologia , Estudos Retrospectivos , Ressecção Transuretral da Próstata/instrumentação , Ressecção Transuretral da Próstata/mortalidade , Uretra/patologia , Uretra/cirurgia
9.
J Surg Res ; 170(2): e217-24, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21816434

RESUMO

BACKGROUND: The rates of post-discharge deaths after surgical procedures are unknown and may represent areas of quality improvement. The NSQIP database captures 30-d outcomes not included within normal administrative databases, and can thus differentiate between in-hospital and post-discharge deaths. METHODS: Retrospective analysis of NSQIP from 2005 through 2007. Inclusion criteria were procedures whose median length of stay was greater than 1 d (to exclude outpatient procedures), and whose overall death rate was greater than 2% (to include only procedures where mortality was a significant issue). Procedures where less than 25 deaths occurred were excluded (for sample size concerns). RESULTS: There were 363,897 patients with 2236 different CPT codes captured in NSQIP. There were 6395 deaths; among them, 1486 (23.2%) occurred after discharge. Thirty-eight CPT codes met the analysis threshold. In two of the CPT codes, there were no post-discharge deaths (repair of ruptured abdominal aortic aneurysm [AAA], repair of ruptured AAA involving iliacs). In the other 36 CPT codes, the proportion of deaths occurring after discharge ranged from 6.3% (repair of thoracoabdominal aneurysm) to 50.0% (femoral-distal bypass with vein). The highest percentage of post-discharge mortality occurs on d 1 after discharge. Fifty percent of post-discharge mortality occurs by d 7; 95% occurs by d 21. CONCLUSION: Approximately one-fourth of postoperative deaths occur after hospital discharge. There is significant variation across surgical procedures in the likelihood of postoperative deaths occurring after discharge. These data indicate a need for closer and more frequent monitoring of post-surgical patients. These data also call into question conclusions drawn from hospital-based outcomes analyses for at least some key diseases/procedures. This analysis demonstrates the power of the risk-adjusted 30-d follow-up NSQIP data, but perhaps more importantly, the responsibility of surgeons to monitor and optimize the discharge process.


Assuntos
Aneurisma da Aorta Abdominal/mortalidade , Bases de Dados Factuais/estatística & dados numéricos , Avaliação de Resultados em Cuidados de Saúde/estatística & dados numéricos , Alta do Paciente/estatística & dados numéricos , Complicações Pós-Operatórias/mortalidade , Aneurisma da Aorta Torácica/mortalidade , Apendicectomia/mortalidade , Colecistectomia/mortalidade , Ponte de Artéria Coronária/mortalidade , Feminino , Mortalidade Hospitalar , Humanos , Histerectomia/mortalidade , Incidência , Tempo de Internação/estatística & dados numéricos , Masculino , Estudos Retrospectivos , Fatores de Risco , Ressecção Transuretral da Próstata/mortalidade , Procedimentos Cirúrgicos Vasculares/mortalidade
10.
J Urol ; 185(6): 2248-53, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21497849

RESUMO

PURPOSE: We analyzed the impact of hospital volume and laser use on postoperative complications and in-hospital mortality in transurethral prostatic surgery. MATERIALS AND METHODS: We evaluated data from 18,578 patients in 686 hospitals who underwent transurethral prostatic surgery between July and December, 2006 to 2008, using the Diagnosis Procedure Combination database in Japan. Cases were divided into low (14 or less per year), medium (14 to 29 per year) or high (30 or more per year) hospital volume groups. Logistic regression analyses were conducted to determine the concurrent effects of hospital volume, laser use and other factors on postoperative complications, transfusion and in-hospital mortality. Laser devices included neodymium:yttrium aluminum garnet and holmium:yttrium aluminum garnet lasers. RESULTS: The overall in-hospital mortality was 0.05% (10 of 18,578 patients) and was not significantly different among groups. The transfusion rates of the low, medium and high volume groups were 8.3%, 7.0% and 5.5%, respectively (low vs high volume adjusted odds ratio 1.55, p <0.01), and postoperative complication rates were 3.7%, 3.2% and 2.6% (low vs high volume OR 1.425, p = 0.016), respectively. An absence of laser use was also a significant risk factor on both measures (OR 1.46 and 2.02, both p <0.01). Teaching hospitals were associated with a higher transfusion rate (OR 1.75), and comorbidities of chronic lung disease, chronic renal failure and malignancy were related to complication rates (OR 1.89, 2.32 and 1.50, respectively). CONCLUSIONS: The mortality rate of transurethral prostatic surgery is extremely low and is not affected by hospital volume. However, higher surgical volumes and laser use were significantly associated with lower rates of complications and transfusions.


Assuntos
Mortalidade Hospitalar , Hospitais/estatística & dados numéricos , Terapia a Laser/estatística & dados numéricos , Hiperplasia Prostática/cirurgia , Ressecção Transuretral da Próstata/efeitos adversos , Ressecção Transuretral da Próstata/mortalidade , Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia
11.
J Urol ; 180(1): 246-9, 2008 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-18499179

RESUMO

PURPOSE: Transurethral resection of the prostate has for decades been the standard surgical therapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia, the most common benign neoplasm in men. To generate a contemporary reference for evolving medical and minimally invasive therapies we analyzed complications and immediate outcomes of transurethral prostate resection in a statewide multicenter study. MATERIALS AND METHODS: We prospectively evaluated 10,654 patients undergoing transurethral prostate resection in the state of Bavaria, Germany from January 1, 2002 until December 31, 2003. Case records containing 54 items concerning preoperative status, operation details, complications and immediate outcome, were recorded for each patient. RESULTS: The mortality rate for transurethral prostate resection was 0.10%. The cumulative short-term morbidity rate was 11.1%. The most relevant complications were failure to void (5.8%), surgical revision (5.6%), significant urinary tract infection (3.6%), bleeding requiring transfusions (2.9%) and transurethral resection syndrome (1.4%). The resected tissue averaged 28.4 gm. Incidental carcinoma of the prostate was diagnosed by histological examination in 9.8% of patients. Urinary peak flow rate increased significantly to 21.6 +/- 9.4 ml per second (baseline 10.4 +/- 6.8 ml per second, 1 tail p <0.0001), while post-void residual decreased to 31.1 +/- 73.0 ml (baseline 180.3 +/- 296.9 ml, 1-tail p <0.0001). CONCLUSIONS: In a large scale evaluation comprising 44 mostly nonacademic urological departments in Bavaria, unique real-world data for transurethral prostate resection were prospectively generated. This most contemporary information should be of use to potential patients and facilitate subsumption of emerging surgical and nonsurgical benign prostatic hyperplasia treatment options.


Assuntos
Hiperplasia Prostática/cirurgia , Ressecção Transuretral da Próstata/efeitos adversos , Ressecção Transuretral da Próstata/mortalidade , Idoso , Idoso de 80 Anos ou mais , Humanos , Masculino , Estudos Prospectivos , Fatores de Tempo , Resultado do Tratamento
12.
Urology ; 72(2): 329-35, 2008 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-18436289

RESUMO

OBJECTIVES: To examine the relationship between the urologist case volume for transurethral resection of the prostate (TURP) and in-hospital mortality using a Taiwan nationwide population-based data set. METHODS: This study used data from the 2003 Taiwan National Health Insurance Research Database. The sample of 9539 patients who had undergone TURP was divided into three urologist caseload volume groups: fewer than 27 cases annually (low volume), 27-55 cases annually (medium volume), and more than 55 cases annually (high volume). Multivariate logistic regression analysis using generalized estimating equations was conducted to assess the adjusted association of urologist TURP caseload volume and patient in-hospital mortality to account for the urologist, patient, and hospital characteristics and the clustered nature of the study sample. RESULTS: The in-hospital mortality rate decreased with an increasing TURP caseload volume. The in-hospital mortality rate was 2.37%, 1.97%, and 1.16% for patients treated in the low, medium, and high-volume urologist group, respectively. After adjusting for others factors, the likelihood of in-hospital mortality for patients treated by urologists with a low and medium TURP caseload volume was 1.835 (95% confidence interval 1.198-2.812, P < .01) and 1.606 (95% confidence interval 1.052-2.452, P < .05) respectively, compared with that for patients treated at high-volume hospitals. CONCLUSIONS: The results of our study have shown that, after adjusting for patient, urologist, and hospital characteristics, high-volume urologists are associated with superior treatment outcomes for patients undergoing TURP.


Assuntos
Mortalidade Hospitalar , Ressecção Transuretral da Próstata/mortalidade , Idoso , Idoso de 80 Anos ou mais , Humanos , Masculino , Taiwan/epidemiologia , Resultado do Tratamento
14.
BJU Int ; 99(1): 56-9, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17034496

RESUMO

OBJECTIVE: To assess the long-term functional and oncological outcome in a consecutive series of patients undergoing palliative transurethral resection of the prostate (pTURP). PATIENTS AND METHODS: We retrospectively assessed all patients who had a pTURP between 1992 and 2004 at our institution. Patients with incidental prostate cancer (pT1a/pT1b) were excluded. In all, 89 patients (mean age 75.9 years, sd 0.9, at diagnosis) entered the study. RESULTS: The median (range) prostate-specific antigen level at diagnosis was 25.7 (0.7-5000) ng/mL and the mean Gleason score was 7. The mean (sd, range) interval between the diagnosis of prostate cancer and pTURP was 1.5 (0.3, 0.5-10.9) years. The indications for pTURP were refractory urinary retention in 30%, severe bladder outlet obstruction with a postvoid residual urine volume of > 100 mL in 43%, and bladder stones, haematuria and hydronephrosis in 9% each. The mean (sd, range) follow-up after pTURP was 2.6 (0.2, 0.1-7.3) years. The peri-operative mortality (<30 days) was 2%, and 22 patients (25%) died during the follow-up. As estimated by Kaplan-Meier analysis, the 1-, 2- and 5-year survival rates were 83%, 70% and 61%, respectively. Patients with prostate cancer in the pTURP specimen had a shorter 3-year survival (52%) than those with a negative histology (89%, P = 0.03). At the last follow-up, 79% of men voided spontaneously and were continent. A repeat pTURP was necessary in 25% of patients, 11% required permanent catheterization and 10% were incontinent. CONCLUSION: Despite greater peri-operative mortality and morbidity than conventional TURP, pTURP is a fairly safe and effective procedure. Although a potential negative impact of pTURP on survival cannot be excluded, the estimated 5-year survival of 61% in this series seems to justify this intervention.


Assuntos
Cuidados Paliativos/métodos , Neoplasias da Próstata/cirurgia , Ressecção Transuretral da Próstata , Idoso , Idoso de 80 Anos ou mais , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Antígeno Prostático Específico/sangue , Neoplasias da Próstata/mortalidade , Neoplasias da Próstata/patologia , Estudos Retrospectivos , Taxa de Sobrevida , Ressecção Transuretral da Próstata/mortalidade , Resultado do Tratamento
15.
Hinyokika Kiyo ; 52(8): 609-14, 2006 Aug.
Artigo em Japonês | MEDLINE | ID: mdl-16972622

RESUMO

A total of 4,031 patients who underwent transurethral resection of the prostate (TURP) performed by one surgeon between May 1979 and December 2003 were retrospectively examined to determine the improvement of the surgeon's skill in performing TURP assessed by using a learning curve, surgical results and postoperative complications. Analysis using the learning curve, which displayed the relationship between the number of TURP procedures and the speed of resection (i.e., the weight of tissue resected divided by the operation time), revealed that 81 operations were needed before the surgeon's skill reached a plateau in performing TURP. The means +/- standard deviations of the weight of tissue resected, operation time and speed of resection were 17.0 +/- 14.6 g, 21.0 +/- 13.5 minutes, 0.80 +/- 0.32 g/minutes, respectively. As the number of TURP procedures increased and the level of skill improved, the operation time was significantly reduced and the speed of resection was significantly increased. The incidences of postoperative complications were 2.4% for blood transfusion, 0.3% for the TURP syndrome, 1.5% for hemostatic procedures, 2.8% for bladder neck contracture, and 1.0% for urethral stricture. The incidences of transfusion and the TURP syndrome decreased as the surgeon's skill improved. The mortality rate was 0.1%.


Assuntos
Ressecção Transuretral da Próstata , Idoso , Idoso de 80 Anos ou mais , Competência Clínica , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Hiperplasia Prostática/cirurgia , Estudos Retrospectivos , Fatores de Tempo , Ressecção Transuretral da Próstata/mortalidade , Ressecção Transuretral da Próstata/normas , Resultado do Tratamento
16.
BJU Int ; 97(4): 758-61, 2006 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-16536768

RESUMO

OBJECTIVES: To ascertain the frequency of in-hospital deaths after urological surgery in a compulsory reporting setting, and to identify the contributing and potentially reversible factors involved in patients who had had transurethral resection of the prostate (TURP). METHODS: We reviewed all hospital deaths reported to the State Coroner from Coronial Services Victoria (CSV), Australia, in 2000-2002 to identify those instances associated with urological surgery. These cases were then analysed using methods developed by CSV. Resources available included medical records, police reports, government data on operative procedures and autopsy results. RESULTS: There were 20 in-hospital deaths after urological surgery identified for the 3-year period; most related to pre-existing comorbidities, predominantly ischaemic heart disease. Two episodes of hospital-acquired infection, two instances of technical complication of surgery contributing to death, and one pulmonary embolus were identified. Numerically the largest group of deaths after surgery was patients having TURP, and these deaths represented 0.05% (nine of 17 044) of all TURPs in this period. Most in this group (eight) had an acute myocardial infarction. CONCLUSION: Death after urological surgery appears to be uncommon; assessing patients for coronary artery disease before urological surgery, particularly TURP, closer cardiovascular monitoring after surgery, and rapid transfer to a coronary care unit if required, may further reduce mortality.


Assuntos
Mortalidade Hospitalar , Procedimentos Cirúrgicos Urológicos/mortalidade , Adolescente , Adulto , Idoso , Austrália/epidemiologia , Causas de Morte , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Cuidados Pós-Operatórios/normas , Doenças Prostáticas/mortalidade , Doenças Prostáticas/cirurgia , Ressecção Transuretral da Próstata/efeitos adversos , Ressecção Transuretral da Próstata/mortalidade , Procedimentos Cirúrgicos Urológicos/efeitos adversos
17.
Eur Urol ; 50(5): 969-79; discussion 980, 2006 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-16469429

RESUMO

OBJECTIVES: To update the complications of transurethral resection of the prostate (TURP), including management and prevention based on technological evolution. METHODS: Based on a MEDLINE search from 1989 to 2005, the 2003 results of quality management of Baden-Württemberg, and long-term personal experience at three German centers, the incidence of complications after TURP was analyzed for three subsequent periods: early (1979-1994); intermediate (1994-1999); and recent (2000-2005) with recommendations for management and prevention. RESULTS: Technological improvements such as microprocessor-controlled units, better armamentarium such as video TUR, and training helped to reduce perioperative complications (recent vs. early) such as transfusion rate (0.4% vs. 7.1%), TUR syndrome (0.0% vs. 1.1%), clot retention (2% vs. 5%), and urinary tract infection (1.7% vs. 8.2%). Urinary retention (3% vs. 9%) is generally attributed to primary detrusor failure rather than to incomplete resection. Early urge incontinence occurs in up to 30-40% of patients; however, late iatrogenic stress incontinence is rare (<0.5%). Despite an increasing age (55% of patients are older than 70), the associated morbidity of TURP maintained at a low level (<1%) with a mortality rate of 0-0.25%. The major late complications are urethral strictures (2.2-9.8%) and bladder neck contractures (0.3-9.2%). The retreatment rate range is 3-14.5% after five years. CONCLUSIONS: TURP still represents the gold standard for managing benign prostatic hyperplasia with decreasing complication rates. Technological alternatives such as bipolar and laser treatments may further minimize the risks of this technically difficult procedure.


Assuntos
Complicações Pós-Operatórias/prevenção & controle , Ressecção Transuretral da Próstata/efeitos adversos , Ressecção Transuretral da Próstata/métodos , Humanos , Incidência , Masculino , Próstata/patologia , Próstata/cirurgia , Ressecção Transuretral da Próstata/mortalidade
19.
Afr. j. urol. (Online) ; 8(1): 20-23, 2002.
Artigo em Inglês | AIM (África) | ID: biblio-1258141

RESUMO

Objectif Evaluer la mortalite et la morbidite precoces apres adenomectomie prostatique par voie transvesicale. Patients et Methodes Nous avons realise une etude descriptive pro-spective de Mars a Juin 1997. Quatre-vingt quatorze patients ont ete inclus. Tous les patients ont fait l'objet d'une evaluation clinique comportant un toucher rectal; ils ont egalement bene-ficie d'une echographie prostatique sus-pubienne. Le bilan pre-operatoire a comporte un dosage de la creatininemie et un bilan complet de l'hemostase. L'adenomectomie prostatique selon la technique de Hrynstchack a ete pratiquee chez tous les patients. Le suivi post-operatoire a consiste en un examen clinique quotidien; les patients ont ensuite ete revus a 1 mois puis a 3 mois. Les incidents et accidents per-operatoires et post-operatoires ont ete notes. Resultats La moyenne d'age de nos patients etait de 70;5 ans avec des extremes de 53 et 93 ans. Le volume moyen de la prostate mesure a l'echographie etait de 95;5 cc avec des extremes de 33 et 324 cc. Avant l'intervention; 54des patients etaient porteurs de sonde. Une cure simultanee de hernie a ete realisee dans 19des cas. La duree moyenne de l'intervention etait inferieure a une heure dans 63des cas. Aucun patient n'a ete transfuse en per-operatoire. Le delai moyen de port de sonde en post operatoire etait de huit jours avec des extremes de deux et 17 jours. La morbidite post-operatoire se resumait en un abces de paroi dans 19des cas; une fistule vesico-cutanee dans 15des cas et une orchiepididymite aigue dans 5des cas. Nous avons egalement note une pollakiurie dans 18des cas; une dysurie dans 8des cas et une imperiosite mictionnelle dans 3;2des cas. La mortalite a ete estimee a 2;14des cas. Conclusion Si la mortalite apres adeno-mectomie prostatique est faible; la morbidite reste elevee. Cette derniere; dominee par les complications infectieuses; est due aux larges indications de la chirurgie ouverte dans un environnement operatoire parfois precaire. C'est dire la necessite de developper la chirurgie par voie endoscopique


Assuntos
Morbidade , Complicações Pós-Operatórias , Prostatectomia , Ressecção Transuretral da Próstata/mortalidade
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