RESUMO
Antihypertensive studies on aqueous-methanolic extract prepared from seeds of Cydonia oblonga M. were carried out. The test extract in 200, 400 and 600 mg/kg doses was investigated in normotensive, high cholesterol and glucose fed hypertensive rats through non-invasive blood pressure measuring technique. Acute and sub-chronic toxicity studies were conducted in mice and rats, respectively. The test extract significantly decreased dose dependently the systolic, diastolic and mean arterial pressures. The test extract in 600mg/kg dose produced maximum effect and prevented rise in blood pressure of high cholesterol diet and glucose fed rats as compare to control in 21 days studies. The extract was found safe up to 4g/kg dose in mice. In sub-chronic toxicity study, no significant alteration in blood chemistry of extract treated rats was observed except reduction in the low density cholesterol levels. It is concluded that Cydonia oblonga seeds extract possess antihypertensive effect which supports its use in folklore.
Assuntos
Anti-Hipertensivos/uso terapêutico , Hipertensão/tratamento farmacológico , Extratos Vegetais/uso terapêutico , Rosaceae/química , Animais , Anti-Hipertensivos/efeitos adversos , Pressão Sanguínea/efeitos dos fármacos , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Feminino , Masculino , Camundongos , Extratos Vegetais/efeitos adversos , Ratos , Ratos Sprague-Dawley , Rosaceae/efeitos adversos , Sementes/efeitos adversos , Sementes/químicaRESUMO
An emergency intervention was performed in a 75-year-old male patient with hypoglycemic attack and blackout. Although he was diagnosed with prediabetes before 2 years, he did not take any anti-diabetic drug or follow dietary advice. He drank Vaccinium corymbosum L (VC) juice daily with a belief that it increases sexual potency. Before the development of hypoglycemia, the patient had consumed about 500 ml VC juice in addition to eating 200-300 gram of Laurocerasus officinalis (LO) fruit. The measured plasma glucose (PG) level during loss of consciousness was 30 mg/dl. The profound hypoglycemia may be an unexpected side effect of an interaction between the chemical compositions of the two plants, occurred as a result of LO fruit intake that may have a strong PG-lowering effect or related to excessive intake of VC juice. Both plants may be considered in the alternative treatment of diabetes.
Assuntos
Bebidas/efeitos adversos , Hipoglicemia/induzido quimicamente , Rosaceae/efeitos adversos , Vaccinium/efeitos adversos , Idoso , Glicemia/análise , Interações Medicamentosas , Frutas/efeitos adversos , Glucose/administração & dosagem , Glucose/uso terapêutico , Humanos , Hipoglicemia/sangue , Hipoglicemia/tratamento farmacológico , Masculino , Resultado do Tratamento , Inconsciência/sangue , Inconsciência/induzido quimicamente , Inconsciência/tratamento farmacológicoAssuntos
Anafilaxia/imunologia , Hipersensibilidade Alimentar/imunologia , Rosaceae/efeitos adversos , Anafilaxia/sangue , Anafilaxia/diagnóstico , Anafilaxia/terapia , Antígenos de Plantas/imunologia , Biomarcadores/sangue , Reações Cruzadas , Feminino , Hipersensibilidade Alimentar/sangue , Hipersensibilidade Alimentar/diagnóstico , Hipersensibilidade Alimentar/terapia , Frutas , Humanos , Imunoglobulina E/sangue , Testes Intradérmicos , Pessoa de Meia-Idade , Técnicas de Diagnóstico Molecular , Valor Preditivo dos Testes , Fatores de Tempo , Resultado do TratamentoRESUMO
BACKGROUND: The use of herbal medicines by pregnant women is on the rise. However, there is limited information regarding the safety of these compounds during pregnancy. Therefore, the goal of this study was to explore the consequences of raspberry leaf use during gestation in Wistar rats. METHODS: Female rats were randomly assigned to receive vehicle, raspberry leaf, or specific flavonoids in raspberry leaf (kaempferol or quercetin; 10 mg/kg per day) orally once breeding had been confirmed until parturition. We assessed pregnancy outcomes in the P generation and reproductive development/fertility in the F1 raspberry leaf-exposed female offspring. RESULTS: Raspberry leaf use during pregnancy was associated with increased gestation length and accelerated reproductive development in the F1 offspring. CONCLUSIONS: Results from this study have shown for the first time that raspberry leaf use during pregnancy can have long-term consequences for the health of the offspring and raise concerns about the safety of this herbal preparation for use during pregnancy.
