RESUMO
A 12-year-old, 3 kg spayed female mixed-breed dog was evaluated to assess a 1-year history of intermittent right forelimb lameness that did not have adequate response to nonsteroidal anti-inflammatory drugs. The radiographic study performed under sedation showed multifocal radiolucent areas affecting both the right humerus and scapula with focal soft tissue swelling; a CT scan confirmed the existence of an aggressive and invasive soft tissue mass affecting the scapulohumeral joint. Fine needle aspiration results suggested a low-grade synovial sarcoma and therefore a scapulectomy was performed. The biopsy showed spindle to stellated cells immersed in a basophilic and mucinous (myxoid) matrix with mild to moderate anisocytosis, moderate anisokaryosis, some binucleated cells and sporadic multinucleated cells. These findings are consistent with low-grade synovial myxosarcoma, a not well described synovial neoplasm that can mimic other commonly seen joint tumors or even septic arthritis on radiographs. The purpose of this case report is to describe the first reported synovial myxosarcoma affecting the scapulohumeral joint of a small dog.
Assuntos
Doenças do Cão , Mixossarcoma , Animais , Cães , Feminino , Doenças do Cão/patologia , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/diagnóstico , Doenças do Cão/cirurgia , Mixossarcoma/veterinária , Mixossarcoma/patologia , Mixossarcoma/diagnóstico , Mixossarcoma/cirurgia , Sarcoma Sinovial/veterinária , Sarcoma Sinovial/patologia , Sarcoma Sinovial/diagnóstico , Sarcoma Sinovial/diagnóstico por imagem , Escápula/patologia , Escápula/diagnóstico por imagem , Coxeadura Animal/etiologiaRESUMO
BACKGROUND: Canine joint sarcomas, designated synovial sarcomas, are uncommon malignant mesenchymal neoplasms that occur in the large joints of the extremities of middle-aged, large-breed dogs. We report the diagnosis of an intrathoracic sarcoma with ultrastructural characteristics reminiscent of human synovial sarcoma in a dog. CASE PRESENTATION: A 7-year-old female spayed Tibetan terrier crossbred dog was presented for acute severe labored breathing and diagnosed with an intrathoracic neoplastic mass. The neoplasm resulted in the accumulation of substantial amounts of viscous pleural fluid that led to dyspnea. The neoplastic mass consisted of interweaving bundles of large pleomorphic mesenchymal cells, supported by an alcian blue positive myxomatous matrix. The neoplastic cells were immunohistochemically negative for cytokeratin and CD18. Transmission electron microscopy indicated that the neoplastic cells had desmosome junctions, short microvilli-like structures and ample amounts of rough endoplasmic reticulum resembling type B-like synoviocytes and synovial sarcoma as reported in people. Despite complete surgical excision of the neoplastic mass, clinical signs recurred after a month and led to the euthanasia of the dog. CONCLUSION: Currently, there are no immunohistochemical markers specific for synovial sarcoma. Canine neoplasms with transmission electron microscopy characteristics resembling type B-like synoviocytes should be considered similar to the human sarcomas that carry the specific translocations between chromosomes X and 18.
Assuntos
Doenças do Cão/patologia , Sarcoma Sinovial/veterinária , Neoplasias Torácicas/veterinária , Animais , Cães , Feminino , Microscopia Eletrônica de Transmissão , Sarcoma Sinovial/patologia , Sarcoma Sinovial/ultraestrutura , Neoplasias Torácicas/patologia , Neoplasias Torácicas/ultraestruturaRESUMO
Sarcoma developing in association with a metallic orthopedic procedure is an uncommon but well-recognized complication in mammals. We report on a synovial sarcoma that developed at the site of an intramedullary pin after surgery to treat a bone fracture. A 17-year-old female peach-faced lovebird (Agapornis roseicollis) developed a spherical mass on the distal right dorsal wing at a site that was previously fractured and surgically repaired with an indwelling intramedullary pin. The right wing was amputated at the scapulohumeral joint. One year later, the bird died. Postmortem examination revealed metastases in the right lung, left thoracic wall, and proventricular serosa. Histologically, the tumor had a characteristic biphasic pattern. The tumor was immunohistologically and ultrastructurally identified as a synovial sarcoma. This is the first report of a suspected fracture-associated sarcoma in a bird.
Assuntos
Agapornis , Doenças das Aves/diagnóstico , Pinos Ortopédicos/veterinária , Neoplasias Ósseas/veterinária , Sarcoma Sinovial/veterinária , Amputação Cirúrgica , Animais , Doenças das Aves/patologia , Pinos Ortopédicos/efeitos adversos , Neoplasias Ósseas/etiologia , Neoplasias Ósseas/patologia , Evolução Fatal , Feminino , Sarcoma Sinovial/etiologia , Sarcoma Sinovial/patologia , Asas de Animais/patologia , Asas de Animais/cirurgiaRESUMO
A subcutaneous tumour was identified in the malar region of a 14-year-old neutered female mixed breed dog. The dog was humanely destroyed and necropsy examination was performed. The tumour did not invade neighbouring tissues and no metastasis was found. Microscopically, the tumour showed a range of features including the presence of multinucleated giant cells, chondrocyte differentiation and cystic or slit-like structures. All of these features are consistent with previously reported descriptions of synovial sarcomas in dogs. Mesenchymal cells accounted for the majority of the tumour, but cytokeratin-positive epithelioid components were also confirmed by immunohistochemistry. The tumour was diagnosed as a biphasic type of synovial sarcoma. Synovial sarcoma in man may develop in tissues unrelated to joints and this is the first report of a non-joint synovial sarcoma in a dog.
Assuntos
Doenças do Cão/patologia , Neoplasias Mandibulares/veterinária , Sarcoma Sinovial/veterinária , Animais , Cães , Feminino , Neoplasias Mandibulares/patologia , Sarcoma Sinovial/patologiaRESUMO
Synovial sarcoma is a rare tumor in dogs, occurring in approximately 27% of neoplasms involving joints, with the elbow representing a common site of occurrence. The recommended treatment of canine synovial sarcoma is amputation. The authors describe the use of palliative radiation therapy for the treatment of synovial sarcoma involving the elbow of a dog and conclude that this treatment modality may have use in some patients affected with synovial sarcoma.
Assuntos
Doenças do Cão/diagnóstico , Doenças do Cão/radioterapia , Sarcoma Sinovial/veterinária , Neoplasias de Tecidos Moles/veterinária , Animais , Diagnóstico Diferencial , Doenças do Cão/patologia , Cães , Feminino , Membro Anterior , Imageamento por Ressonância Magnética/veterinária , Cuidados Paliativos , Radioterapia Assistida por Computador/veterinária , Sarcoma Sinovial/diagnóstico , Sarcoma Sinovial/radioterapia , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/radioterapiaAssuntos
Doenças do Cão/diagnóstico por imagem , Sarcoma Sinovial/veterinária , Neoplasias de Tecidos Moles/veterinária , Amputação Cirúrgica/veterinária , Animais , Quimioterapia Adjuvante/veterinária , Doenças do Cão/diagnóstico , Doenças do Cão/cirurgia , Cães , Feminino , Membro Posterior , Coxeadura Animal/diagnóstico , Coxeadura Animal/diagnóstico por imagem , Radiografia , Sarcoma Sinovial/diagnóstico , Sarcoma Sinovial/diagnóstico por imagem , Sarcoma Sinovial/cirurgia , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/diagnóstico por imagem , Neoplasias de Tecidos Moles/cirurgia , Resultado do TratamentoRESUMO
[123I]-iodo-L-phenylalanine was successfully evaluated for gamma camera imaging in vivo in tumor-bearing athymic mice and in humans with brain tumors. Here, we report the use of this tracer in two dogs with synovial cell sarcoma of the tarsus. [123I]-iodo-L-phenylalanine was quantitatively prepared as a kit formulation using the Cu(1+) +-assisted nucleophilic exchange. Rapid [123I]-2-iodo-L-phenylalanine tumor accumulation was observed with good tumor to background contrast and rapid clearance in these two dogs. This radiopharmaceutical is a promising alternative tumor tracer to overcome the known limitations of 18F-fluorodeoxyglucose and, when labelled with radioiodine-131, has the potential to be used for therapeutic purposes.
Assuntos
Doenças do Cão/diagnóstico por imagem , Radioisótopos do Iodo , Compostos Radiofarmacêuticos , Sarcoma Sinovial/veterinária , Animais , Diagnóstico Diferencial , Cães , Feminino , Fíbula/diagnóstico por imagem , Masculino , Radiografia , Sarcoma Sinovial/diagnóstico por imagem , Tíbia/diagnóstico por imagem , Tomografia Computadorizada de Emissão de Fóton Único/veterináriaAssuntos
Doenças do Gato/diagnóstico , Sarcoma Sinovial/veterinária , Neoplasias da Medula Espinal/veterinária , Animais , Doenças do Gato/diagnóstico por imagem , Doenças do Gato/patologia , Gatos , Diagnóstico Diferencial , Feminino , Imageamento por Ressonância Magnética/veterinária , Sarcoma Sinovial/diagnóstico , Neoplasias da Medula Espinal/diagnóstico , Vértebras Torácicas , Tomografia Computadorizada por Raios X/veterináriaAssuntos
Amputação Cirúrgica/veterinária , Doenças do Gato/diagnóstico por imagem , Sarcoma Sinovial/veterinária , Neoplasias de Tecidos Moles/veterinária , Animais , Doenças do Gato/patologia , Doenças do Gato/cirurgia , Gatos , Feminino , Membro Anterior , Radiografia , Sarcoma Sinovial/diagnóstico por imagem , Sarcoma Sinovial/patologia , Sarcoma Sinovial/cirurgia , Neoplasias de Tecidos Moles/diagnóstico por imagem , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/cirurgia , Resultado do TratamentoRESUMO
A 19.5-year-old male mongrel dog developed a progressive lameness and swelling around the right carpus. A tumor (6 x 3 x 3 cm) was found in the caudal of distal antebrachium of the right forelimb, including tendons of the superficial digital flexor muscle and deep digital flexor muscle. No joint destruction was observed. The tumor consisted of round and spindle cells arranged in a compact sheet. There were occasional slit-like spaces or lumina, and areas rich in collagen fibers giving an appearance of tendon tissues. Neoplastic cells gave a positive immunoreaction to vimentin, but negative reactions to antibodies against S-100 protein, cytokeratin and myoglobin. Based on these findings, this tumor was diagnosed as a synovial sarcoma generating from the tendon and tendon sheath, which is very uncommon in dogs.
Assuntos
Doenças do Cão/patologia , Sarcoma Sinovial/veterinária , Tendões/patologia , Animais , Cães , Membro Anterior , Masculino , Sarcoma Sinovial/patologiaAssuntos
Doenças do Cão/diagnóstico , Sarcoma Sinovial/veterinária , Tíbia/patologia , Animais , Neoplasias Ósseas/diagnóstico , Neoplasias Ósseas/patologia , Neoplasias Ósseas/veterinária , Diagnóstico Diferencial , Doenças do Cão/patologia , Cães , Imuno-Histoquímica/veterinária , Radiografia , Sarcoma/diagnóstico , Sarcoma/patologia , Sarcoma/veterinária , Sarcoma Sinovial/diagnóstico , Sarcoma Sinovial/patologia , Tíbia/diagnóstico por imagemAssuntos
Doenças do Cão/diagnóstico , Sarcoma Sinovial/veterinária , Neoplasias de Tecidos Moles/veterinária , Amputação Cirúrgica/veterinária , Animais , Diagnóstico Diferencial , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/cirurgia , Cães , Masculino , Radiografia , Sarcoma Sinovial/diagnóstico , Sarcoma Sinovial/diagnóstico por imagem , Sarcoma Sinovial/cirurgia , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/diagnóstico por imagem , Neoplasias de Tecidos Moles/cirurgia , Resultado do TratamentoAssuntos
Neoplasias Ósseas/veterinária , Doenças do Cão/diagnóstico por imagem , Coxeadura Animal/diagnóstico por imagem , Sarcoma Sinovial/veterinária , Amputação Cirúrgica/veterinária , Animais , Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Ósseas/cirurgia , Doenças do Cão/cirurgia , Cães , Feminino , Coxeadura Animal/cirurgia , Recidiva Local de Neoplasia/veterinária , Radiografia , Sarcoma Sinovial/diagnóstico por imagem , Sarcoma Sinovial/cirurgia , Joelho de Quadrúpedes/patologia , Resultado do TratamentoRESUMO
A 7-year-old Holstein cow developed a large cystic mass in the region between the atlantoaxis and larynx. The mass extended to the synovium in the atlanto-occipital joint. Many villous projections were present on the inner surface of the tumor tissue, and irregular clefts were formed in the inside. Two cell types, epithelioid-like synovioblasts and spindle cells, were present. Immunohistochemical analysis showed that the cells stained positively for cytokeratin (AE1/AE3) and vimentin. Both cells had similar fine structures ultra-structurally. Vacuoles present in the cytoplasm were full of an acid mucous substance. The tumor was diagnosed as a well-differentiated biphasic synovial sarcoma. This is the first report of a rare case of synovial sarcoma, from the viewpoint of its origin.
Assuntos
Articulação Atlantoccipital/patologia , Doenças dos Bovinos/patologia , Sarcoma Sinovial/veterinária , Animais , Articulação Atlantoccipital/ultraestrutura , Bovinos , Feminino , Artropatias/patologia , Artropatias/veterinária , Gravidez , Sarcoma Sinovial/patologia , Sarcoma Sinovial/ultraestruturaRESUMO
Seventeen cases of canine peripheral nerve sheath tumors (PNSTs), 11 malignant PNSTs (MPNSTs), and six benign PNSTs (BPNSTs) were examined. The prognosis in five of six dogs with BPNSTs was excellent, whereas all dogs with MPNSTs died within 2 years after the last surgical resection. One BPNST formed a recurrent mass with features of a MPNST. Histopathologically, the predominant tumor cell of MPNSTs was either spindle or round in shape with epithelioid characteristics. Other atypical cells had abundant granular cytoplasm or were multinucleated giant cells with periodic acid-Schiff-positive cytoplasmic globules. Furthermore, two MPNSTs contained cartilaginous and osseous metaplasia. On the contrary, most BPNSTs exhibited typical features of schwannoma or neurofibroma, whereas two BPNSTs had atypical morphology. One BPNST consisted of epithelioid cell proliferation with some tumor cells revealing nuclear atypia. Immunohistochemically, the expression of vimentin (100%), S-100 (73%), nerve growth factor receptor (NGFR, 64%), and myoglobin (64%) was commonly found in MPNSTs. The two BPNSTs with atypical histologic appearances were positive for vimentin, S-100, NGFR, and neuron-specific enolase, and one of these had moderate immunoreactivity for cytokeratin. Most BPNSTs were positive for glial fibrillary acidic protein, as well as S-100 and NGFR. Although most rhabdomyosarcomas (RMSs) and canine hemangiopericytomas (CHPs) also showed focal immunoreactivity for S-100, most RMSs were intensely positive for myoglobin and negative for NGFR. Most CHPs (80%) exhibited focal alpha-smooth muscle actin (alpha-SMA) expression, whereas all PNSTs were negative. These results indicate that immunohistochemistry for NGFR and alpha-SMA might be useful for differentiating canine PNSTs from RMSs or CHPs, respectively.
Assuntos
Biomarcadores Tumorais/análise , Doenças do Cão/diagnóstico , Hemangiopericitoma/veterinária , Neoplasias de Bainha Neural/veterinária , Rabdomiossarcoma/veterinária , Sarcoma Sinovial/veterinária , Animais , Cães , Feminino , Hemangiopericitoma/química , Hemangiopericitoma/diagnóstico , Imuno-Histoquímica/veterinária , Imunofenotipagem/veterinária , Masculino , Neoplasias de Bainha Neural/química , Neoplasias de Bainha Neural/diagnóstico , Prognóstico , Rabdomiossarcoma/química , Rabdomiossarcoma/diagnóstico , Sarcoma Sinovial/química , Sarcoma Sinovial/diagnósticoRESUMO
The clinical, radiological and pathologic features of a biphasic synovial sarcoma in the left elbow joint of a two-year-old male Rottweiler are presented. The tumor showed positive immunoreactivity for vimentin, Epithelial Membrane Antigen (EMA), p53 and PCNA, while it was negative for the cytokeratin used, S-100, Rb and p21. Immunohistochemistry for EMA allowed the identification of epithelioid components of synovial sarcoma, and may, therefore, contribute in establishing a diagnosis of biphasic synovial sarcoma. Intratumoral variation in PCNA immunoreactivity was minimal, indicating that the various tumor components proliferate at more or less similar rates. Overall, the characterized immunohistochemical profile for canine synovial sarcoma, not defined previously, may provide clues to the histogenesis of the phenotypically mesenchymal and epithelial elements of the tumor, and may be of value in the differential diagnosis of challenging cases, decreasing the risk of under- and mis-diagnosis. Although more cases need to be studied to determine whether there is a consistent pattern of immunostaining in canine synovial sarcoma, its potential significance is discussed in relation to the histogenesis, molecular pathology and differential diagnosis of canine synovial sarcoma.
Assuntos
Doenças do Cão/patologia , Sarcoma Sinovial/veterinária , Neoplasias de Tecidos Moles/veterinária , Animais , Doenças do Cão/diagnóstico por imagem , Cães , Articulação do Cotovelo/anormalidades , Articulação do Cotovelo/diagnóstico por imagem , Articulação do Cotovelo/patologia , Membro Anterior , Histocitoquímica/veterinária , Imuno-Histoquímica/veterinária , Queratinas/análise , Masculino , Mucina-1/análise , Proteína Oncogênica p21(ras)/análise , Antígeno Nuclear de Célula em Proliferação/análise , Radiografia , Proteína do Retinoblastoma/análise , Sarcoma Sinovial/química , Sarcoma Sinovial/diagnóstico por imagem , Sarcoma Sinovial/patologia , Neoplasias de Tecidos Moles/química , Neoplasias de Tecidos Moles/diagnóstico por imagem , Proteína Supressora de Tumor p53/análise , Vimentina/análiseAssuntos
Hemangiossarcoma/veterinária , Doenças dos Cavalos/diagnóstico , Neoplasias Bucais/veterinária , Segunda Neoplasia Primária/veterinária , Animais , Diagnóstico Diferencial , Hemangiossarcoma/diagnóstico , Doenças dos Cavalos/congênito , Doenças dos Cavalos/diagnóstico por imagem , Doenças dos Cavalos/patologia , Doenças dos Cavalos/cirurgia , Cavalos , Articulação Metacarpofalângica , Neoplasias Bucais/diagnóstico , Segunda Neoplasia Primária/diagnóstico , Radiografia , Sarcoma Sinovial/diagnóstico , Sarcoma Sinovial/veterinária , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/veterináriaAssuntos
Doenças do Cão/diagnóstico , Membro Posterior , Sarcoma Sinovial/veterinária , Neoplasias de Tecidos Moles/veterinária , Joelho de Quadrúpedes , Animais , Diagnóstico Diferencial , Doenças do Cão/diagnóstico por imagem , Cães , Coxeadura Animal/diagnóstico por imagem , Imageamento por Ressonância Magnética , Masculino , Radiografia , Sarcoma Sinovial/diagnóstico , Sarcoma Sinovial/diagnóstico por imagem , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/diagnóstico por imagemRESUMO
Pertinent patient data and biopsied tissue from 16 cases of canine synovial sarcoma (SS) were reviewed. Histopathological grade, clinical stage, and tissue immunoreactivity to cytokeratin (broad stain, AE1/AE3 and cytokeratin 7) and vimentin were determined and correlated with survival. Effect of treatment on survival was similarly evaluated. Neither clinical stage nor histopathological grade significantly affected survival patterns. Tissues from all cases stained >30% positively with vimentin, whereas no tissue from any case exhibited cytokeratin immunoreactivity. Dogs receiving surgical tumor excision or amputation had a significantly higher survivability than those receiving no treatment (P<0.02). Treatment aggressiveness may be more appropriate than clinical staging or tumor grading in predicting survival. Reliability of diagnosing and prognosticating canine SS with current immunohistochemistry protocols should be questioned.