RESUMO
Necrotizing sialometaplasia (NS) is a self-limiting, benign, ischemic, inflammatory disease that is most often described in the submandibular glands of dogs, with clinical and histologic features that resemble malignancy. Unilateral swelling of the parotid salivary gland in a 7-year-old Cocker Spaniel dog was diagnosed as NS. The dog also had otitis externa on the same side as the parotid gland lesions. The main histologic features were included lobular necrosis of salivary tissue; fibrinoid necrosis of some arteries; marked squamous metaplasia of duct and/or acinar epithelium, with intercellular bridge formation; preservation of salivary lobular morphology; and variable inflammation and fibrosis. Etiologic factors for NS in both humans and animals remain obscure.
Assuntos
Doenças do Cão/diagnóstico , Glândula Parótida/patologia , Sialometaplasia Necrosante/veterinária , Animais , Doenças do Cão/patologia , Doenças do Cão/cirurgia , Cães , Masculino , Sialometaplasia Necrosante/diagnóstico , Sialometaplasia Necrosante/patologia , Sialometaplasia Necrosante/cirurgiaRESUMO
Systemic granulomatous disease involving the spleen, heart, lymph nodes, omentum, liver, kidney, lung, mediastinum, and salivary glands developed in an 8-year-old Rottweiler. The dog also had sialometaplasia of both submandibular salivary glands. Bartonella henselae and B. vinsonii subsp. berkhoffii DNA was amplified from the salivary gland by polymerase chain reaction analysis. Bartonellae may be the cause of this systemic disease, but to the authors' knowledge, involvement of omentum, mediastinum, and salivary glands has not previously been reported in association with Bartonella infection. Bartonellae should be considered potential causes of sialometaplasia.
Assuntos
Infecções por Bartonella/veterinária , Doenças do Cão/patologia , Doença Granulomatosa Crônica/veterinária , Sialometaplasia Necrosante/veterinária , Animais , Infecções por Bartonella/complicações , Cães , Feminino , Doença Granulomatosa Crônica/microbiologia , Doença Granulomatosa Crônica/patologia , Sialometaplasia Necrosante/microbiologia , Sialometaplasia Necrosante/patologiaRESUMO
Unilateral swelling of submandibular salivary gland in two cats was diagnosed as necrotising sialometaplasia. Histological features that differentiate the disease from other salivary gland lesions, particularly neoplasia are: lobular necrosis of salivary tissue; squamous metaplasia conforming to duct and/or acinar outlines; preservation of salivary lobular morphology; and variable inflammation and granulation tissue.
Assuntos
Doenças do Gato/diagnóstico , Sialometaplasia Necrosante/veterinária , Animais , Doenças do Gato/patologia , Doenças do Gato/cirurgia , Gatos , Diagnóstico Diferencial , Feminino , Masculino , Sialometaplasia Necrosante/diagnósticoRESUMO
Necrotizing sialometaplasia (NS) is a distinct, though rare disease of the salivary glands. Histologic findings in humans and dogs are identical, but the distribution of affected glands and clinical course are very different. Small terrier breeds are predisposed. Clinically, canine NS is characterized by nausea (i.e., ptyalism, lip smacking, gulping), dysphagia, and pain in the mandibular region. Surgical removal of the affected glands produces minimal, if any, improvement; however, transient administration of anticonvulsants has resulted in dramatic clinical improvement in three cases.