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Geroscience ; 44(5): 2427-2445, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-36367599

RESUMO

Convalescent plasma therapy might be a feasible option for treatment of novel infections. During the early phases of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, several promising results were published with convalescent plasma therapy, followed by more disappointing findings of randomised controlled trials. In our single-centre, open-label, prospective, cohort study, we assessed the findings of 180 patients treated with convalescent plasma during the first four waves of the pandemic in Hungary. The primary outcome was all-cause mortality; secondary outcomes were clinical improvement and need for intensive care unit admission by day 28. Subgroup analysis comparing elderly and non-elderly (less than 65 years of age) was performed. Twenty (11.4%) patients died by day 28, at significantly higher rates in the elderly subgroup (3 vs. 17, p < 0.01). One hundred twenty-eight (72.7%) patients showed clinical improvement, and 15 (8.5%) were transferred to the intensive care unit until day 28. Non-elderly patients showed clinical improvement by day 28 in significantly higher rates (improvement 74 vs. 54, no improvement 15 vs. 11, worsening or death 4 vs. 18 patients, p < 0.01). In conclusion, we found similar clinical outcome results as randomised controlled trials, and the impact of risk factors for unfavourable clinical outcomes among patients in the elderly population.


Assuntos
Soroterapia para COVID-19 , COVID-19 , Idoso , Humanos , Pessoa de Meia-Idade , COVID-19/epidemiologia , COVID-19/terapia , Soroterapia para COVID-19/efeitos adversos , Hungria/epidemiologia , Estudos Prospectivos , Adulto , Ensaios Clínicos Controlados Aleatórios como Assunto , Pandemias , Hospitalização , Resultado do Tratamento
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