Investigation of radiosterilization and dosimetric features of sulfacetamide sodium.

In the present work, the spectroscopic and kinetic features of the radical species induced in gamma-irradiated sulfacetamide-sodium (SS) was studied at room and at different temperatures in the dose range of 5-50kGy by electron spin resonance (ESR) technique with the aim of investigating the possibility of radiosterilization and dosimetric features of SS. A model consisting of four radical species of different spectroscopic features denoted as I-IV was found to describe best whole experimental data derived throughout the present work. These species were quite stable at room temperature but relatively unstable above room temperature. Heights of the characteristic resonance peaks measured with respect to the base line were considered to monitor microwave, temperature, time dependent and kinetic features of the radical species contributing to ESR spectrum. Collected experimental data were used to characterize the radical species responsible from ESR spectra through simulation calculations. Possible changes in the IR bands of gamma irradiated SS was also investigated by FT-IR technique, but no definite difference was observed between unirradiated and irradiated IR spectra of SS. As in other sulfonamides, radiation yield of solid SS was found to be very low (G

The effect of antioxidants on the photolysis of aqueous sulfacetamide and sulfanilamide solutions.

Aqueous sulfacetamide and sulfanilamide solutions were photolyzed at pH 1-13 and in the presence of various antioxidants and a chelating agent (pH 7.0). The rate constants for the photodegradation of sulfacetamide and sulfanilamide were determined. Sodium metabisulfite and thiourea were the best antioxidants for the photostabilization of sulfacetamide and sulfanilamide solutions respectively. Sodium edetate is also an effective stabilizer in sulfacetamide solutions. The efficiency of the antioxidants on the basis of product distribution and the kinetic results is discussed.

Degradation studies on sulphacetamide eye-drops. Part 2: Spectrophotometric evaluation of decomposition products of UV-irradiated solutions of sulphacetamide.

Multicomponent spectrophotometric assay methods have been used for quantitative determination of major photodecomposition products of sulphacetamide solutions. The reproducibility of the assay method lie within 4% of error. The hydrolysis of sulphacetamide to sulphanilamide and the oxidation of sulphanilamide to a blue product is a first-order reaction while the formation of azo dye from sulphanilamide is found to be a second-order reaction. A general scheme of photodegration pathways for sulphacetamide and sulphanilamide is presented.