DeepDrRVO: A GAN-auxiliary two-step masked transformer framework benefits early recognition and differential diagnosis of retinal vascular occlusion from color fundus photographs.

Retinal vascular occlusion (RVO) are common causes of visual impairment. Accurate recognition and differential diagnosis of RVO are unmet medical needs for determining appropriate treatments and health care to properly manage the ocular condition and minimize the damaging effects. To leverage deep learning as a potential solution to detect RVO reliably, we developed a deep learning model on color fundus photographs (CFPs) using a two-step masked SwinTransformer with a Few-Sample Generator (FSG)-auxiliary training framework (called DeepDrRVO) for early and differential RVO diagnosis. The DeepDrRVO was trained on the training set from the in-house cohort and achieved consistently high performance in early recognition and differential diagnosis of RVO in the validation set from the in-house cohort with an accuracy of 86.3%, and other three independent multi-center cohorts with the accuracy of 92.6%, 90.8%, and 100%. Further comparative analysis showed that the proposed DeepDrRVO outperforms conventional state-of-the-art classification models, such as ResNet18, ResNet50d, MobileNetv3, and EfficientNetb1. These results highlight the potential benefits of the deep learning model in automatic early RVO detection and differential diagnosis for improving clinical outcomes and providing insights into diagnosing other ocular diseases with a few-shot learning challenge. The DeepDrRVO is publicly available on https://github.com/ZhouSunLab-Workshops/DeepDrRVO.

Frontiers in diabetic retinal disease.

Diabetic retinal disease (DRD) remains a leading cause of vision loss and blindness globally. Although treatments can be effective when given at vision-threatening stages of DRD, there is a lack of knowledge about the earliest mechanisms leading to the development of clinically evident DRD. Recent advances in retinal imaging methods for patients with diabetes allow a more precise and granular characterization of the different stages of DRD than is provided by the classic Diabetic Retinopathy Severity Scale based on fundus photographs. In addition, recent clinical studies have yielded more information on how to adjust blood glucose levels, lipid levels and blood pressure to minimize the risk of DRD. Given the incomplete success of current therapies, there is a critical need for better understanding of the mechanisms underlying DRD and novel treatment targets that address the entire neurovascular retina. Moreover, the causes for interindividual variability in the development of DRD in patients with similar glycemic history and other metabolic factors are not yet clarified either. Finally, greater focus on patients' experience with visual disabilities and treatment effects should be addressed in research in this field.

[An Autopsy Case of Death After Deep Sedation of Thiopental].

The victim was a morbidly obese and bull-necked woman in her twenties. She had the disorders, due to Down's syndrome, including severe mental retardation, advanced hearing loss, congenital cataract surgery, and amblyopia at postoperative glaucoma. She was deeply sedated for rest with an intravenous drip infusion of 350 mg of thiopental (TP) for 5 minutes during an intraocular pressure examination with secondary glaucoma at a hospital. The examination was finished within 10 minutes after the TP injection, but her respiratory condition deteriorated rapidly when the doctor left the patient. Although immediate artificial respiration was carried out, she was declared dead about 20 hours after the examination. Medical malpractice was suspected for her death. At autopsy, no fatal disease or injury was observed in the victim. The serum TP level was 0.80 µg /ml. TP is an ultra-short-acting intravenous anesthetic, and usually only the smallest amount should be administered by frequent additions after pre-anesthesia administration while maintaining contact with patients. Although contact with patients with a disability can be difficult, it was diagnosed that the death was caused by both respiratory arrest due to a single dose of TP and delay in resuscitation due to the absence of a doctor.

Pain-Relieving Interventions for Retinopathy of Prematurity: A Meta-analysis.

CONTEXT: Retinopathy of prematurity eye examinations conducted in the neonatal intensive care. OBJECTIVE: To combine randomized trials of pain-relieving interventions for retinopathy of prematurity examinations using network meta-analysis. DATA SOURCES: Systematic review and network meta-analysis of Medline, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and the World Health Organization International Clinical Trials Registry Platform. All databases were searched from inception to February 2017. STUDY SELECTION: Abstract and title screen and full-text screening were conducted independently by 2 reviewers. DATA EXTRACTION: Data were extracted by 2 reviewers and pooled with random effect models if the number of trials within a comparison was sufficient. The primary outcome was pain during the examination period; secondary outcomes were pain after the examination, physiologic response, and adverse events. RESULTS: Twenty-nine studies (N = 1487) were included. Topical anesthetic (TA) combined with sweet taste and an adjunct intervention (eg, nonnutritive sucking) had the highest probability of being the optimal treatment (mean difference [95% credible interval] versus TA alone = -3.67 [-5.86 to -1.47]; surface under the cumulative ranking curve = 0.86). Secondary outcomes were sparsely reported (2-4 studies, N = 90-248) but supported sweet-tasting solutions with or without adjunct interventions as optimal. LIMITATIONS: Limitations included moderate heterogeneity in pain assessment reactivity phase and severe heterogeneity in the regulation phase. CONCLUSIONS: Multisensory interventions including sweet taste is likely the optimal treatment for reducing pain resulting from eye examinations in preterm infants. No interventions were effective in absolute terms.

Fracturas orbitarias / Orbital fractures

Introducción: las fracturas de la órbita son comunes y difíciles de manejar. Objetivo: realizar una revisión bibliográfica sobre las consideraciones anatómicas, fisiopatología, diagnóstico, tratamiento y complicaciones de las fracturas orbitarias. Métodos: se realizó una revisión bibliográfica en septiembre de 2016. Se evaluaron revistas de impacto de Web of Sciencies (35 revistas). Se consultaron las bases de datos MEDLINE, PubMed y SciELO con los descriptores: orbital fracture, treatment, epidemiology. Se incluyeron artículos en idioma inglés y español de los últimos 5 años. Se obtuvieron 127 artículos. El estudio se circunscribió a 47. Análisis e integración de la información: la órbita presenta debilidad anatómica en el piso y la pared medial que provoca una mayor afectación por fracturas. Existen varias teorías que justifican su aparición. El diagnóstico se basa en los hallazgos clínicos, incluidos los oftalmológicos, y medios auxiliares de diagnóstico; lo cual permite escoger la modalidad terapéutica y evitar complicaciones. Conclusiones: basados en el dominio de la anatomía y los métodos diagnósticos, la gestión de estas lesiones ha cambiado poco en los últimos años. Sin embargo, los avances en las imágenes orbitales, la introducción de sistemas de navegación intraoperatoria, mejores indicaciones quirúrgicas y diseños de implantes han llevado a una reevaluación del enfoque terapéutico de las fracturas orbitarias(AU)

Introduction: fractures of the orbit are common and difficult to manage. Objective: to carry out a bibliographic review on anatomical considerations, physiopathology, diagnosis, treatment and complications of orbital fractures. Methods: abibliographic review was carried out in September 2016. Journals of impact in the Web of Sciences (35 journals) were evaluated. The databases MedLine, PubMed and ScieELO were consulted with the descriptors: orbital fracture, treatment, and epidemiology. Articles in English and Spanish language of the last 5 years were included. 127 articles were obtained. The study was circumscribed to 47. Analysis and integration of information: the orbit presents anatomical weakness in the floor and the medial wall, which causes greater affectation due to fractures. There are several theories that justify its onset. The diagnosis is based on clinical findings, including ophthalmological findings, and diagnostic aids, which allows choosing the therapeutic modality and avoiding complications. Conclusions: based on the mastery of anatomic and diagnostic methods, the management of these lesions has changed little in recent years. However, advances in orbital imaging, the introduction of intraoperative navigation systems, better surgical indications and implant designs have led to a reassessment of the therapeutic approach to orbital fractures(AU)

Fracturas orbitarias / Orbital fractures

Introducción: las fracturas de la órbita son comunes y difíciles de manejar. Objetivo: realizar una revisión bibliográfica sobre las consideraciones anatómicas, fisiopatología, diagnóstico, tratamiento y complicaciones de las fracturas orbitarias. Métodos: se realizó una revisión bibliográfica en septiembre de 2016. Se evaluaron revistas de impacto de Web of Sciencies (35 revistas). Se consultaron las bases de datos MEDLINE, PubMed y SciELO con los descriptores: orbital fracture, treatment, epidemiology. Se incluyeron artículos en idioma inglés y español de los últimos 5 años. Se obtuvieron 127 artículos. El estudio se circunscribió a 47. Análisis e integración de la información: la órbita presenta debilidad anatómica en el piso y la pared medial que provoca una mayor afectación por fracturas. Existen varias teorías que justifican su aparición. El diagnóstico se basa en los hallazgos clínicos, incluidos los oftalmológicos, y medios auxiliares de diagnóstico; lo cual permite escoger la modalidad terapéutica y evitar complicaciones. Conclusiones: basados en el dominio de la anatomía y los métodos diagnósticos, la gestión de estas lesiones ha cambiado poco en los últimos años. Sin embargo, los avances en las imágenes orbitales, la introducción de sistemas de navegación intraoperatoria, mejores indicaciones quirúrgicas y diseños de implantes han llevado a una reevaluación del enfoque terapéutico de las fracturas orbitarias(AU)

Introduction: fractures of the orbit are common and difficult to manage. Objective: to carry out a bibliographic review on anatomical considerations, physiopathology, diagnosis, treatment and complications of orbital fractures. Methods: abibliographic review was carried out in September 2016. Journals of impact in the Web of Sciences (35 journals) were evaluated. The databases MedLine, PubMed and ScieELO were consulted with the descriptors: orbital fracture, treatment, and epidemiology. Articles in English and Spanish language of the last 5 years were included. 127 articles were obtained. The study was circumscribed to 47. Analysis and integration of information: the orbit presents anatomical weakness in the floor and the medial wall, which causes greater affectation due to fractures. There are several theories that justify its onset. The diagnosis is based on clinical findings, including ophthalmological findings, and diagnostic aids, which allows choosing the therapeutic modality and avoiding complications. Conclusions: based on the mastery of anatomic and diagnostic methods, the management of these lesions has changed little in recent years. However, advances in orbital imaging, the introduction of intraoperative navigation systems, better surgical indications and implant designs have led to a reassessment of the therapeutic approach to orbital fractures(AU)

Influencia del tabaquismo, la hipertensión arterial y la diabetes mellitus en las enfermedades oftalmológicas / Influence of smoking, hypertension and diabetes mellitus in ophthalmological diseases

El presente trabajo tiene como propósito describir la posible influencia de los factores de riesgo aterosclerótico (tabaquismo, hipertensión arterial y diabetes mellitus) en las enfermedades oftalmológicas: glaucoma primario de ángulo abierto, catarata, retinopatía diabética e hipertensiva, y degeneración macular asociada a la edad. Se realizó una búsqueda sistematizada en las bases de datos Scielo, Sciencedirect y Elsevier. El tabaquismo aumenta el riesgo de padecer, y acelera la progresión, tanto del glaucoma primario de ángulo abierto como de la catarata, la retinopatía diabética e hipertensiva y la degeneración macular asociada a la edad. La hipertensión arterial y la diabetes mellitus, además de conducir a las retinopatías correspondientes, también incrementan la probabilidad de desarrollar glaucoma primario de ángulo abierto, y son considerados factores de mal pronóstico al favorecer su progresión. El control del tabaquismo, de la hipertensión y de la diabetes mellitus mejorará el pronóstico de estas afecciones oftalmológicas, y en algunos casos evitará o retardará su aparición(AU)

The purpose of the present work is to describe the possible influence of the atherosclerotic risk factors (smoking, hypertension and diabetes mellitus) in the ophthalmological illnesses: primary glaucoma of open angle, waterfall, diabetic and hypertensive retinopathy, and macular degeneration associated to the age. Eye diseases such as glaucoma, cataract, diabetic and hypertensive retinopathy and age-related macular degeneration are closely related to atherosclerotic risk factors: smoking, hypertension and diabetes mellitus. Knowing how these factors influence ocular structures will facilitate the diagnosis and treatment of these conditions. Systematic search was made in Scielo, Sciencedirect and Elsevier databases. Smoking increases the risk of suffering and accelerates the progression of primary open-angle glaucoma, as well as cataract, diabetic and hypertensive retinopathy, and age-related macular degeneration. Hypertension and diabetes mellitus, in addition to leading to corresponding retinopathies, also increase the likelihood of developing open-angle primary glaucoma; they are even considered poor prognosis factors since they prompt its progression. The control of smoking, hypertension and diabetes mellitus will therefore improve the prognosis of these ophthalmological conditions, and in some cases will prevent or delay their onset(AU)

Influencia del tabaquismo, la hipertensión arterial y la diabetes mellitus en las enfermedades oftalmológicas / Influence of smoking, hypertension and diabetes mellitus in ophthalmological diseases

El presente trabajo tiene como propósito describir la posible influencia de los factores de riesgo aterosclerótico (tabaquismo, hipertensión arterial y diabetes mellitus) en las enfermedades oftalmológicas: glaucoma primario de ángulo abierto, catarata, retinopatía diabética e hipertensiva, y degeneración macular asociada a la edad. Se realizó una búsqueda sistematizada en las bases de datos Scielo, Sciencedirect y Elsevier. El tabaquismo aumenta el riesgo de padecer, y acelera la progresión, tanto del glaucoma primario de ángulo abierto como de la catarata, la retinopatía diabética e hipertensiva y la degeneración macular asociada a la edad. La hipertensión arterial y la diabetes mellitus, además de conducir a las retinopatías correspondientes, también incrementan la probabilidad de desarrollar glaucoma primario de ángulo abierto, y son considerados factores de mal pronóstico al favorecer su progresión. El control del tabaquismo, de la hipertensión y de la diabetes mellitus mejorará el pronóstico de estas afecciones oftalmológicas, y en algunos casos evitará o retardará su aparición(AU)

The purpose of the present work is to describe the possible influence of the atherosclerotic risk factors (smoking, hypertension and diabetes mellitus) in the ophthalmological illnesses: primary glaucoma of open angle, waterfall, diabetic and hypertensive retinopathy, and macular degeneration associated to the age. Eye diseases such as glaucoma, cataract, diabetic and hypertensive retinopathy and age-related macular degeneration are closely related to atherosclerotic risk factors: smoking, hypertension and diabetes mellitus. Knowing how these factors influence ocular structures will facilitate the diagnosis and treatment of these conditions. Systematic search was made in Scielo, Sciencedirect and Elsevier databases. Smoking increases the risk of suffering and accelerates the progression of primary open-angle glaucoma, as well as cataract, diabetic and hypertensive retinopathy, and age-related macular degeneration. Hypertension and diabetes mellitus, in addition to leading to corresponding retinopathies, also increase the likelihood of developing open-angle primary glaucoma; they are even considered poor prognosis factors since they prompt its progression. The control of smoking, hypertension and diabetes mellitus will therefore improve the prognosis of these ophthalmological conditions, and in some cases will prevent or delay their onset(AU)

Manifestaciones oftalmológicas en pacientes diabéticos de un área de salud / Ophthalmological manifestations in diabetic patients from a health area

Objetivo: describir el comportamiento de manifestaciones oftalmológicas de anexos y segmento anterior en pacientes diabéticos de un área de salud. Métodos: se realizó un estudio descriptivo transversal. La muestra fue conformada por 134 pacientes diabéticos. Se aplicaron métodos de estadística descriptiva para variables cualitativas. Para el procesamiento y análisis de la información se confeccionó una base de datos en programa estadístico Microsoft Excel 2003. Resultados: el 88,8 por ciento de los pacientes tenían más de 50 años. Predominaron el grupo de 60-69 años, con edad media de 62,5 años; el sexo femenino a razón de 97:37 y la diabetes mellitus tipo 2 (97,8 por ciento), con menos de 5 años de evolución (57,4 por ciento). Las enfermedades oculares que se presentaron con mayor frecuencia fueron ojo seco (76,1 por ciento), blefaritis (41,7 por ciento), pterigion (20,1 por ciento), tortuosidad vascular conjuntival (15,6 por ciento), engrosamiento conjuntival (11,1 por ciento), queratitis punctata y neurotrófica (4,5 por ciento) seguida de herpes zoster oftálmico (2,2 por ciento), rubeosis del iris (1,5 por ciento) y úlcera corneal y catarata (0,8 por ciento). Conclusiones: la diabetes mellitus es un problema de salud real. Las personas diabéticas presentan con frecuencia daño ocular como ojo seco, blefaritis, queratitis, entre otros, por lo que deben consultar al oftalmólogo periódicamente(AU)

Objective : to describe the behavior of the ophthalmologic manifestations of annexes and previous segment in diabetic patients in an area of health. Method: a carried out a traverse descriptive study. The sample was constituted by134 diabetic patients. Methods of descriptive statistic were applied for qualitative variables. For the prosecution and analysis of the information a database was made in statistical program Microsoft Excel 2003. Results: 88,8 percent of the patients had more than 50 years prevailing the 60-69 year-old group, with half age 62,5 years old. The feminine sex prevailed to reason of 97:37. Diabetes mellitus type 2 prevailed (97,8 percent), with less than 5 years of evolution (57,4 percent). The ocular pathologies that were presented with more frequency were dry eye (76,1 percent), blepharitis (41,7 percent), pterigion (20,1 percent), tortuosity vascular conjunctival (15,6 percent), and conjunctival engrosamiento (11,1 percent). Punctata keratopathy and neurotropic keratopathy (4,5 percent) followed by herpes zoster ophthalmicus (2,2 percent), rubeosis of the iris (1,5 percent) and corneal ulcer, waterfall (0,8 percent). Conclusions: the diabetic mellitus is a problem of real health. Diabetic people frequently present ocular damage as dry eye, blepharitis, keratopathy among other, for what they should attend the oculist periodically(AU)

Manifestaciones oftalmológicas en pacientes diabéticos de un área de salud / Ophthalmological manifestations in diabetic patients from a health area

Objetivo: describir el comportamiento de manifestaciones oftalmológicas de anexos y segmento anterior en pacientes diabéticos de un área de salud. Métodos: se realizó un estudio descriptivo transversal. La muestra fue conformada por 134 pacientes diabéticos. Se aplicaron métodos de estadística descriptiva para variables cualitativas. Para el procesamiento y análisis de la información se confeccionó una base de datos en programa estadístico Microsoft Excel 2003. Resultados: el 88,8 por ciento de los pacientes tenían más de 50 años. Predominaron el grupo de 60-69 años, con edad media de 62,5 años; el sexo femenino a razón de 97:37 y la diabetes mellitus tipo 2 (97,8 por ciento), con menos de 5 años de evolución (57,4 por ciento). Las enfermedades oculares que se presentaron con mayor frecuencia fueron ojo seco (76,1 por ciento), blefaritis (41,7 por ciento), pterigion (20,1 por ciento), tortuosidad vascular conjuntival (15,6 por ciento), engrosamiento conjuntival (11,1 por ciento), queratitis punctata y neurotrófica (4,5 por ciento) seguida de herpes zoster oftálmico (2,2 por ciento), rubeosis del iris (1,5 por ciento) y úlcera corneal y catarata (0,8 por ciento). Conclusiones: la diabetes mellitus es un problema de salud real. Las personas diabéticas presentan con frecuencia daño ocular como ojo seco, blefaritis, queratitis, entre otros, por lo que deben consultar al oftalmólogo periódicamente(AU)

Objective : to describe the behavior of the ophthalmologic manifestations of annexes and previous segment in diabetic patients in an area of health. Method: a carried out a traverse descriptive study. The sample was constituted by134 diabetic patients. Methods of descriptive statistic were applied for qualitative variables. For the prosecution and analysis of the information a database was made in statistical program Microsoft Excel 2003. Results: 88,8 percent of the patients had more than 50 years prevailing the 60-69 year-old group, with half age 62,5 years old. The feminine sex prevailed to reason of 97:37. Diabetes mellitus type 2 prevailed (97,8 percent), with less than 5 years of evolution (57,4 percent). The ocular pathologies that were presented with more frequency were dry eye (76,1 percent), blepharitis (41,7 percent), pterigion (20,1 percent), tortuosity vascular conjunctival (15,6 percent), and conjunctival engrosamiento (11,1 percent). Punctata keratopathy and neurotropic keratopathy (4,5 percent) followed by herpes zoster ophthalmicus (2,2 percent), rubeosis of the iris (1,5 percent) and corneal ulcer, waterfall (0,8 percent). Conclusions: the diabetic mellitus is a problem of real health. Diabetic people frequently present ocular damage as dry eye, blepharitis, keratopathy among other, for what they should attend the oculist periodically(AU)

Safety of anterior chamber paracentesis using a 30-gauge needle integrated with a specially designed disposable pipette.

AIMS: To investigate the safety of anterior chamber (AC) paracentesis using a 30-gauge needle integrated with a specially designed disposable pipette. METHODS: In this retrospective observational case-series study, AC paracentesis was performed on 301 eyes of 301 patients between September 2009 and August 2016 at the Department of Ophthalmology, Kyoto Prefectural University of Medicine and the Baptist Eye Institute, Kyoto, Japan. AC paracentesis was performed with the patient placed in the supine position using a 30-gauge needle integrated with a disposable pipette with one hand, and the safety post procedure was then evaluated. RESULTS: The indications for AC paracentesis were virus detection (ie, corneal endotheliitis, anterior infectious uveitis, cytomegalovirus retinitis and acute retinal necrosis) in 264 eyes, bacterial detection (ie, endophthalmitis) in 8 eyes and malignancy (ie, primary intraocular lymphoma, leukaemia and retinoblastoma) in 29 eyes. No serious complications such as infection, hyphema, lens trauma or severe inflammation including hypopyon and AC fibrin formation were observed. CONCLUSIONS: Our findings show that AC paracentesis with a disposable pipette is safe with no severe complications.

Posterior Retinal Hemorrhages during Retcam Examination for Retinopathy of Prematurity.

BACKGROUND: Retcam-assisted retinopathy of prematurity (ROP) screening is a commonly used safe examination procedure. CASE CHARACTERISTICS: A preterm baby born at 32 weeks gestation age developed extensive posterior retinal hemorrhages during retinal imaging using the RetCam. OUTCOME: Retinal hemorrhages spontaneously resolved. MESSAGE: As tele screening is becomes more popular, proper training for Retcam usage is essential.

Paracetamol (acetaminophen) for prevention or treatment of pain in newborns.

BACKGROUND: Newborn infants have the ability to experience pain. Hospitalised infants are exposed to numerous painful procedures. Healthy newborns are exposed to pain if the birth process consists of assisted vaginal birth by vacuum extraction or by forceps and during blood sampling for newborn screening tests. OBJECTIVES: To determine the efficacy and safety of paracetamol for the prevention or treatment of procedural/postoperative pain or pain associated with clinical conditions in neonates. To review the effects of various doses and routes of administration (enteral, intravenous or rectal) of paracetamol for the prevention or treatment of pain in neonates. SEARCH METHODS: We used the standard search strategy of the Cochrane Neonatal Review group to search the Cochrane Central Register of Controlled Trials (CENTRAL 2016, Issue 4), MEDLINE via PubMed (1966 to 9 May 2016), Embase (1980 to 9 May 2016), and CINAHL (1982 to 9 May 2016). We searched clinical trials' databases, Google Scholar, conference proceedings, and the reference lists of retrieved articles. SELECTION CRITERIA: We included randomised and quasi-randomised controlled trials of paracetamol for the prevention/treatment of pain in neonates (≤ 28 days of age). DATA COLLECTION AND ANALYSIS: Two review authors independently extracted data from the articles using pre-designed forms. We used this form to decide trial inclusion/exclusion, to extract data from eligible trials and to request additional published information from authors of the original reports. We entered and cross-checked data using RevMan 5 software. When noted, we resolved differences by mutual discussion and consensus. We used the GRADE approach to assess the quality of evidence. MAIN RESULTS: We included nine trials with low risk of bias, which assessed paracetamol for the treatment of pain in 728 infants. Painful procedures studied included heel lance, assisted vaginal birth, eye examination for retinopathy of prematurity assessment and postoperative care. Results of individual studies could not be combined in meta-analyses as the painful conditions, the use of paracetamol and comparison interventions and the outcome measures differed. Paracetamol compared with water, cherry elixir or EMLA cream (eutectic mixture of lidocaine and prilocaine) did not significantly reduce pain following heel lance. The Premature Infant Pain Profile score (PIPP) within three minutes following lancing was higher in the paracetamol group than in the oral glucose group (mean difference (MD) 2.21, 95% confidence interval (CI) 0.72 to 3.70; one study, 38 infants). Paracetamol did not reduce "modified facies scores" after assisted vaginal birth (one study, 119 infants). In another study (n = 123), the Échelle de Douleur et d'Inconfort du Nouveau-Né score at two hours of age was significantly higher in the group that received paracetamol suppositories than in the placebo suppositories group (MD 1.00, 95% CI 0.60 to 1.40). In that study, when infants were subjected to a heel lance at two to three days of age, Bernese Pain Scale for Neonates scores were higher in the paracetamol group than in the placebo group, and infants spent a longer time crying (MD 19 seconds, 95% CI 14 to 24). For eye examinations, no significant reduction in PIPP scores in the first or last 45 seconds of eye examination was reported, nor at five minutes after the eye examination. In one study (n = 81), the PIPP score was significantly higher in the paracetamol group than in the 24% sucrose group (MD 3.90, 95% CI 2.92 to 4.88). In one study (n = 114) the PIPP score during eye examination was significantly lower in the paracetamol group than in the water group (MD -2.70, 95% CI -3.55 to 1.85). For postoperative care following major surgery, the total amount of morphine (µg/kg) administered over 48 hours was significantly less among infants assigned to the paracetamol group than to the morphine group (MD -157 µg/kg, 95% CI -27 to -288). No adverse events were noted in any study. The quality of evidence according to GRADE was low. AUTHORS' CONCLUSIONS: The paucity and low quality of existing data do not provide sufficient evidence to establish the role of paracetamol in reducing the effects of painful procedures in neonates. Paracetamol given after assisted vaginal birth may increase the response to later painful exposures. Paracetamol may reduce the total need for morphine following major surgery, and for this aspect of paracetamol use, further research is needed.

Cribaje visual en la Atención Primaria de Salud en menores de tres años / Visual screening in under three-year old children at the primary health care

Objetivos: determinar el grado de concordancia entre los resultados de la aplicación, por pediatras de Atención Primaria, del cribaje visual que establece una guía de práctica clínica, propuesta para cuidados visuales preventivos en edad pediátrica y el criterio de verdad dado por el examen de especialistas en Oftalmología. Métodos: se realizó un estudio descriptivo, prospectivo y transversal en una muestra de 481 pacientes de 6 a 35 meses de edad, en la consulta de Oftalmología del hospital pediátrico Marfán, de febrero del año 2014 a enero de 2015. Participaron dos especialistas en Pediatría, de Atención Primaria, dos especialistas en Oftalmología y un licenciado en Óptica y Optometría. El análisis de la concordancia entre los resultados del cribado visual realizado por pediatras y el criterio de verdad se realizó mediante el cálculo del índice Kappa a partir de cuatro variables, empleando el programa epitat 4. Resultados: la estimación de la fuerza de concordancia fue buena en el examen del comportamiento visual y del reflejo de fondo de ojo con K= 0,649 y 0,754; muy buena en el examen externo de anexos, globo ocular y alineación ocular, con K= 0,817 y 0,899. Conclusiones: el nivel de concordancia diagnóstica encontrado entre pediatras y oftalmólogos hace factible la aplicación de los procedimientos de examen que establece la Guía de Práctica Clínica propuesta(AU)

Objectives: to determine the level of agreement between the results of the application by primary health carepediatricians of the visual screening that sets a clinical practice guideline for preventive visual care at pediatric ages and the true criteria from the test performed by ophthalmologists. Methods: descriptive, prospective and cross-sectional study of a sample of 481 children aged 6 to 35 months old, who were seen at the ophthalmology service of Marfan pediatric hospital from February 2014 to January 2015. Two primary health care pediatricians, two ophthalmologists and a certified optometrist participated. The analysis of the level of agreement between the results of the visual screening by pediatricians and the truth criterion was made through the calculation of Kappa´s agreement index based on four variables by using Epidat 4 program. Results: the estimation of the force of agreement was good in the visual behavior and in the fundus reflection, with k= 0.649 and 0.754, respectively; it was very good in the external exam of the adnexa, the eyeball and the ocular alignment with k= 0.817 and 0.899, respectively. Conclusions: the level of diagnostic agreement found between ophthalmologists and pediatricians makes the application of the examination procedures established by the suggested clinical practice guideline possible(AU)

Safety and Feasibility of Quantitative Multiplexed Cytokine Analysis From Office-Based Vitreous Aspiration.

PURPOSE: The goals of this study were to evaluate the safety of office-based vitreous sampling, and determine the utility of these samples with multiplex cytokine analysis. METHODS: Vitreous samples were collected from office-based needle aspiration and the rate of adverse events during follow-up was reviewed. The vitreous cytokine concentrations in a subset of patients with diabetic macular edema (DME) were analyzed using a 42 plex-cytokine bead array. These results were compared with vitreous cytokine concentrations in proliferative diabetic retinopathy (PDR) and controls (macular hole, epiretinal membrane, symptomatic vitreous floaters) from pars plana vitrectomy. RESULTS: An adequate volume of vitreous fluid (100-200 µL) was obtained in 52 (88%) of 59 office-based sampling attempts. The average length of follow-up was 300 days (range, 42-926 days). There were no complications, including cataract, retinal tear or detachment, and endophthalmitis. Two patients (3%) had posterior vitreous detachments within 3 months. Vitreous cytokine concentrations were measured in 44 patients: 14 controls, 13 with DME, and 17 with PDR. The concentration of ADAM11, CXCL-10, IL-8, and PDGF-A were higher in PDR compared with controls and DME. The concentration of IL-6 was higher in PDR compared with controls, but not compared with DME. CONCLUSIONS: Office-based vitreous aspiration is safe and yields high-quality samples for multiplex vitreous cytokine analysis. Significant elevations of vitreous cytokines were found in PDR compared with DME and controls, including the novel finding of elevated ADAM11. As such, office-based aspiration is a safe and effective means to identify vitreous factors associated with vitreoretinal disease.

Alteraciones oftalmológicas durante el embarazo / Ocular alterations during pregnancy

Los trastornos oftalmológicos son muy comunes durante el embarazo. Se realiza la presente revisión con el objetivo de documentar las variadas condiciones oculares que podrían aparecer durante la gestación o se podrían modificar por esta, lo que conllevaría estar bien atentos sobre las gestantes que aquejan trastornos visuales. Durante el período de gestación las mujeres se exponen a variados cambios tanto a nivel sistémico como ocular. A partir de algunos de estos cambios, el embarazo origina alteraciones a nivel ocular, los cuales son la mayoría de las veces transitorias, aunque en ocasiones pueden establecerse de forma permanente. Los efectos oculares del embarazo pueden ser fisiológicos, patológicos o pueden ocasionar modificaciones de condiciones prexistentes. De esta manera, pueden observarse en este período cambios a nivel de los párpados, la córnea, el cristalino, la presión intraocular, el campo visual, entre otros. También exacerbaciones de patologías como retinopatía diabética, enfermedad de Grave y retinitis por toxoplasma, así como complicaciones provocadas por el propio embarazo como preclampsia-eclampsia, desprendimiento de retina seroso, ceguera cortical, síndrome de HELLP, retinopatía serosa central, etcétera. Se relacionan además alteraciones neuroftalmológicas y complicaciones oftálmicas en relación con el parto, como trombosis del seno venoso, adenoma pituitario, hipertensión intracraneal benigna, neuritis óptica, así como retinopatía y síndrome de Sheehan(AU)

Ocular disorders are very common in pregnancy. The present review was aimed at documenting the varied eye conditions that might occur during pregnancy or might be modified by it, which would imply that pregnant women suffering visual disorders should be carefully watched. During pregnancy, women are exposed to a range of changes both at the systemic and ocular levels.so much at systemic as ocular level. Due to some of these changes, the pregnancy gives rise to ocular changes which are mostly temporary, although they may occasionally become permanent. The ocular effects of pregnancy can be physiologic, pathological or they can modify pre-existing conditions. In this period, one can observe changes in the eyelids, the cornea, the crystalline lens, the intraocular pressure, the visual field and others. There is also exacerbations in pathologies such as diabetic retinopathy, Grave´s disease and toxoplasmic retinitis, as well as complications derived from pregnancy as is the case of preclampsia-eclampsia, serous retinal detachment, cortical blindness, HELLP syndrome, central serous retinopathy, among others. Neurophthalmological and ophthalmic complications in connection with the delivery such as venous sinus thrombosis, benign intracranial hypertension, pituitary adenoma, meningioma and optic neuritis as well as retinopathy and Sheehan´s syndrome were found(AU)

Alteraciones oftalmológicas durante el embarazo / Ocular alterations during pregnancy

Los trastornos oftalmológicos son muy comunes durante el embarazo. Se realiza la presente revisión con el objetivo de documentar las variadas condiciones oculares que podrían aparecer durante la gestación o se podrían modificar por esta, lo que conllevaría estar bien atentos sobre las gestantes que aquejan trastornos visuales. Durante el período de gestación las mujeres se exponen a variados cambios tanto a nivel sistémico como ocular. A partir de algunos de estos cambios, el embarazo origina alteraciones a nivel ocular, los cuales son la mayoría de las veces transitorias, aunque en ocasiones pueden establecerse de forma permanente. Los efectos oculares del embarazo pueden ser fisiológicos, patológicos o pueden ocasionar modificaciones de condiciones prexistentes. De esta manera, pueden observarse en este período cambios a nivel de los párpados, la córnea, el cristalino, la presión intraocular, el campo visual, entre otros. También exacerbaciones de patologías como retinopatía diabética, enfermedad de Grave y retinitis por toxoplasma, así como complicaciones provocadas por el propio embarazo como preclampsia-eclampsia, desprendimiento de retina seroso, ceguera cortical, síndrome de HELLP, retinopatía serosa central, etcétera. Se relacionan además alteraciones neuroftalmológicas y complicaciones oftálmicas en relación con el parto, como trombosis del seno venoso, adenoma pituitario, hipertensión intracraneal benigna, neuritis óptica, así como retinopatía y síndrome de Sheehan(AU)

Ocular disorders are very common in pregnancy. The present review was aimed at documenting the varied eye conditions that might occur during pregnancy or might be modified by it, which would imply that pregnant women suffering visual disorders should be carefully watched. During pregnancy, women are exposed to a range of changes both at the systemic and ocular levels.so much at systemic as ocular level. Due to some of these changes, the pregnancy gives rise to ocular changes which are mostly temporary, although they may occasionally become permanent. The ocular effects of pregnancy can be physiologic, pathological or they can modify pre-existing conditions. In this period, one can observe changes in the eyelids, the cornea, the crystalline lens, the intraocular pressure, the visual field and others. There is also exacerbations in pathologies such as diabetic retinopathy, Grave´s disease and toxoplasmic retinitis, as well as complications derived from pregnancy as is the case of preclampsia-eclampsia, serous retinal detachment, cortical blindness, HELLP syndrome, central serous retinopathy, among others. Neurophthalmological and ophthalmic complications in connection with the delivery such as venous sinus thrombosis, benign intracranial hypertension, pituitary adenoma, meningioma and optic neuritis as well as retinopathy and Sheehan´s syndrome were found(AU)

Performing red reflex eye examinations increases the rate of neonatal conjunctivitis.

AIM: Red reflex eye examinations often require opening the eyelids, risking infection. We evaluated links between this procedure and neonatal conjunctivitis. METHODS: We divided 18 872 neonates of more than 35 weeks of gestation into two birth periods, 2008-2009 and 2010-2011, before and after red reflex examinations were carried out by our facility. The rates of clinical conjunctivitis, bacterial conjunctivitis and bacterial growth percentage were compared between the two periods. RESULTS: The 2010-2011 period included more Caesarean deliveries and longer lengths of stay (LOS) than the 2008-2009 period. The clinical conjunctivitis rate increased significantly during 2010-2011 (p = 0.029), but the bacterial conjunctivitis and bacterial growth percentages did not differ between the two periods. Variables that were independently and significantly associated with clinical conjunctivitis included being born in 2010-2011, with an odds ratio (OR) of 1.22, male gender (OR 1.31) and LOS (OR 1.19). Bacterial conjunctivitis was associated with vaginal delivery (OR 3.65), males delivered by Caesarean (OR 2.68) and LOS (OR 1.37). CONCLUSION: Clinical conjunctivitis was significantly associated with the later study period, male gender and LOS. Conjunctival swab sampling increased significantly following the implementation of red reflex examinations, but without changes in the bacterial conjunctivitis rate and the bacterial growth percentage.

In vivo corneal confocal microscopy as a novel non-invasive tool to investigate cardiac autonomic neuropathy in Type 1 diabetes.

AIMS: To investigate whether small nerve fibre degeneration detected using corneal confocal microscopy is associated with cardiac autonomic neuropathy in people with Type 1 diabetes. METHODS: Thirty-six people with Type 1 diabetes and 20 age- and sex-matched healthy control subjects were enrolled. Tests to determine heart rate response to deep-breathing (expiratory-to-inspiratory ratio), heart rate response to lying-to-stand test (30:15 ratio) and blood pressure response to standing were performed to detect cardiac autonomic neuropathy. Corneal confocal microscopy was performed to assess: corneal nerve density and corneal nerve beadings; branching pattern; and nerve fibre tortuosity. RESULTS: Compared with control participants, participants with Type 1 diabetes had fewer (mean ± SD 45.4 ± 20.2 vs 92.0 ± 22.7 fibres/mm²; P < 0.001) and more tortuous corneal nerve fibres (20 participants with Type 1 diabetes vs four control participants had nerve tortuosity grade 2/3; P = 0.022) and fewer beadings (mean ± SD 15.1 ± 3.5 vs 20.6 ± 5.0; P < 0.001). Of the participants with Type 1 diabetes, 11 met the criteria for the diagnosis of cardiac autonomic neuropathy. Corneal nerve density was significantly lower in participants with cardiac autonomic neuropathy than in those without (mean ± SD 32.8 ± 16.4 vs 51.7 ± 18.9 fibres/mm²; P = 0.008). This difference remained significant after adjustment for age (P = 0.02), gender (P = 0.04), disease duration (P = 0.005), insulin requirement (P = 0.02) and neuropathy disability score (P = 0.04). CONCLUSION: This study suggests that corneal confocal microscopy could represent a new and non-invasive tool to investigate cardiac autonomic neuropathy in people with Type 1 diabetes. Larger studies are required to define the role of corneal confocal microscopy in the assessment of cardiac autonomic neuropathy.

Widespread retinal hemorrhages after retinopathy of prematurity screening with scleral depression.

We report a case of extensive bilateral intraretinal hemorrhages in a premature infant with active retinopathy of prematurity (ROP) after an examination with scleral depression. In the only other previously reported case, the retinal hemorrhages were limited to the posterior pole of an eye with preexisting vitreous hemorrhage, and the child had a history of severe necrotizing enterocolitis that required surgery. Investigators have hypothesized that the combination of ocular manipulation, abrupt intraocular pressure change, and fragile immature retinal vasculature with poor autoregulation may contribute to the pathogenesis of retinal hemorrhages. Physicians performing ROP examinations should be aware of this possibility and judiciously use scleral depression; however, examination-induced retinal hemorrhages in children have never been reported in the absence of active ROP.