RESUMO
OBJECTIVE: To assess the effectiveness and safety of treating erythematotelangiectatic rosacea using fractional radiofrequency (FRF). METHODS: Twenty patients with a confirmed diagnosis of erythema capillaris rosacea were selected, and one side of each patient's face was randomly assigned to receive FRF treatments for three to six times, with an interval of 2 weeks between each treatment. VISIA, dermoscopy, and the Clinician's Erythema Evaluation Scale (CEA) were applied to evaluate the efficacy of the treatment before and after the treatment, to record the VAS scores and adverse reactions, and to conduct a patient satisfaction survey. RESULTS: The characteristic counts and scores of red zone and porphyrin as assessed by VISIA test were significantly decreased, and the difference between the treated side and the pretreatment side was statistically significant (p < 0.05), and the efficacy of the treatment was statistically insignificant compared with the control side, except for the red zone and porphyrin which were statistically significant before and after the treatment (p > 0.05). By CEA score, the difference between the treated side after treatment and the control side was statistically significant (p < 0.05), and the difference between the treated side before and after treatment was statistically significant (p < 0.05); the difference between the control side before and after treatment was not statistically significant (p > 0.05). Dermatoscopic observation showed reduction in pore size, reduction of yellowish-white and black horn plugs within the pores, lightening of the red background and thinning and blurring of the capillary structure on the treated side of the skin compared to the control side, and the skin on the treated side showed the above mentioned changes before and after the treatment as well. The mean pain score of the subjects was obtained by VAS score 3.67 ± 0.90. Adverse effects included mild edema, erythema, and microscopic crusting; no long-term adverse effects were seen in all patients. The efficacy of FRF treatment was evaluated 1 month after the final treatment, and 85% of the subjects rated it as satisfactory, very satisfactory, and very satisfactory. CONCLUSION: FRF for the treatment of erythematous capillary dilatation rosacea is effective, safe, and suitable for clinical promotion.
Assuntos
Satisfação do Paciente , Rosácea , Humanos , Rosácea/terapia , Rosácea/diagnóstico , Rosácea/radioterapia , Feminino , Adulto , Pessoa de Meia-Idade , Resultado do Tratamento , Masculino , Terapia por Radiofrequência/efeitos adversos , Terapia por Radiofrequência/métodos , Dermoscopia , Eritema/etiologia , Eritema/terapia , Telangiectasia/terapia , Telangiectasia/radioterapia , Telangiectasia/diagnóstico por imagem , Adulto Jovem , Índice de Gravidade de Doença , Face , Pele/efeitos da radiação , Pele/patologia , Pele/diagnóstico por imagem , Pele/irrigação sanguínea , Anormalidades Múltiplas , Sobrancelhas/anormalidades , Doença de DarierRESUMO
Microneedle fractional radiofrequency (MFRF) has been used to improve photoaging and scars. This study aimed to evaluate the efficacy and safety of MFRF with basic fibroblast growth factor (bFGF) for facial atrophic acne scars and skin rejuvenation by blinded visual evaluation, self-report, and reflective confocal microscopy (RCM). Fifteen subjects were randomized to the MFRF with bFGF group and fifteen to the MFRF group. All subjects underwent three-session therapy and a follow-up period. Significant group differences were in ECCA, global improvement score, satisfaction, and downtime before and after treatment. Combination therapy could be more effective than monotherapy for acne scars and facial rejuvenation. In addition, RCM can be used to observe the changes in skin collagen before and after treatment in evaluating cosmetic efficacy.
Assuntos
Acne Vulgar , Cicatriz , Técnicas Cosméticas , Rejuvenescimento , Humanos , Acne Vulgar/complicações , Feminino , Adulto , Cicatriz/etiologia , Cicatriz/terapia , Técnicas Cosméticas/instrumentação , Técnicas Cosméticas/efeitos adversos , Fator 2 de Crescimento de Fibroblastos , Terapia por Radiofrequência/métodos , Terapia por Radiofrequência/efeitos adversos , Masculino , Agulhas , Face , Satisfação do Paciente , Terapia Combinada , Pessoa de Meia-Idade , Sistemas de Liberação de Medicamentos/instrumentação , Envelhecimento da Pele , Atrofia , Adulto JovemRESUMO
BACKGROUND: The negative effects of skin aging are primarily related to the destruction of dermal architectural structure. More specifically, this includes changes in the spatial arrangement of collagen, elastin fibers, mucopolysaccharides, proteoglycans, and ground substances. AIMS: The purpose of this study is to investigate the histologic effects of dermal and subdermal tissue after a controlled single treatment with radiofrequency (RF) macroneedling. This therapy provides a controlled, localized, thermal effect on the dermis whereby triggering the body's own healing processes of extracellular matrix remodeling. Clinically benefits include skin tightening. METHODS: Biopsies were obtained for histologic evaluation from four patients (n = 4), 4 weeks after completing a single RF macroneedling facial treatment. RESULTS: Age-related changes of the dermal and subdermal architecture were observed at baseline. After treatment, all biopsies demonstrated an increase in epidermal cells, collagen, elastin, fibroblasts, vasculature, and a decrease in inflammatory cells. CONCLUSIONS: The results of this histologic study confirm a significant "subsurfacing" thermal effect from the noncoagulative ascendant thermal injury. The obtained results characterize RF macroneedling therapy as an effective method for correcting age-related changes in facial skin.
Assuntos
Terapia por Radiofrequência , Envelhecimento da Pele , Humanos , Envelhecimento da Pele/efeitos da radiação , Feminino , Pessoa de Meia-Idade , Terapia por Radiofrequência/métodos , Terapia por Radiofrequência/efeitos adversos , Terapia por Radiofrequência/instrumentação , Derme/efeitos da radiação , Derme/patologia , Biópsia , Elastina/metabolismo , Elastina/análise , Face , Adulto , Idoso , Colágeno/metabolismo , Fibroblastos/efeitos da radiação , Masculino , Pele/efeitos da radiação , Pele/patologia , Técnicas Cosméticas/efeitos adversos , Técnicas Cosméticas/instrumentação , Resultado do TratamentoRESUMO
OBJECTIVE: To investigate the histological properties of microplasma radiofrequency (MPRF) using a stationary tip in different treatment strategies on porcine skin. METHODS: Two Bama miniature pigs received MPRF treatment with two types of stationary tips in eight groups of parameters (power, duration, and pass) on dorsal skin. Skin samples were collected from each treatment zone immediately, at 1 week and 1, 3, and 6 months after treatment. Hematoxylin and eosin (HE) and Masson staining were performed to assess histologic changes as well as neocollagenesis. The dynamic changes of heat shock protein 47 (HSP47) and heat shock protein 72 (HSP72) were also detected by immunohistochemistry. RESULTS: Skin damage increased with pulse energy, duration, and pass. Longer durations or repeated treatments may cause particularly severe skin damage. During the wound healing process, the newborn collagen of the dermis is rearranged. The distribution of HSP47 and HSP72 was consistent with the extent of collagen remodeling. It peaked 1 month after treatment. CONCLUSION: MPRF can effectively cause epidermal ablation, dermal collagen hyperplasia, and remodeling. Increasing power should be the first choice when increasing treatment intensity. For longer durations or repeated treatments, caution should be taken to avoid excessive skin trauma.
Assuntos
Pele , Porco Miniatura , Animais , Suínos , Pele/efeitos da radiação , Pele/patologia , Cicatrização/efeitos da radiação , Proteínas de Choque Térmico HSP47/metabolismo , Terapia por Radiofrequência/métodos , Terapia por Radiofrequência/efeitos adversos , Terapia por Radiofrequência/instrumentação , Colágeno/metabolismo , Proteínas de Choque Térmico HSP72/metabolismo , Proteínas de Choque Térmico HSP72/análise , Ondas de Rádio/efeitos adversosRESUMO
BACKGROUND: Microplasma fractional radiofrequency (MP FRF) technology has been increasingly used for acne scars. Nevertheless, little evidence has analyzed the factors influencing its effectiveness before and during treatment. AIMS: To evaluate the clinical factors affecting the effectiveness of MP FRF therapy for atrophic acne scars. METHODS: We analyzed retrospectively the clinical data of 79 acne scar patients treated with MP FRF technology. The outcome of interest included the effectiveness and adverse events after MP FRF treatment. Multivariable logistic regression was utilized to evaluate clinical factors associated with effectiveness after the initial session. RESULTS: All patients received 115 sessions of MP FRF therapy (average: 1.5 sessions). Twenty-eight (35.4%) patients improved moderately to excellently after one session. We found that the severe grade before treatment was negatively correlated with the effectiveness according to Goodman-Baron qualitative scores (OR = 0.02, 95% CI [0.001, 0.37], p = 0.009). The presence of icepick scars was also a negative correlation factor for the effectiveness (OR = 0.06, 95% CI [0.004, 1.00], p = 0.049). Furthermore, after excluding the effects of icepick scars and Goodman-Baron scores before treatment, ECCA scores were also correlated with effectiveness (OR = 1.04, 95% CI [1.01, 1.06], p = 0.009). CONCLUSION: MP FRF therapy was effective in treating atrophic acne scars with no permanent adverse events. The severity of Goodman-Baron qualitative scores and icepick scars were independent clinical factors affecting effectiveness, suggesting the possible requirement for additional treatments other than MP FRF for severe acne scars and icepick scars.
Assuntos
Acne Vulgar , Atrofia , Cicatriz , Humanos , Acne Vulgar/complicações , Acne Vulgar/terapia , Estudos Retrospectivos , Cicatriz/etiologia , Cicatriz/terapia , Cicatriz/diagnóstico , Feminino , Adulto , Masculino , Resultado do Tratamento , Adulto Jovem , Atrofia/etiologia , Índice de Gravidade de Doença , Terapia por Radiofrequência/métodos , Terapia por Radiofrequência/efeitos adversos , Adolescente , Tratamento por Radiofrequência Pulsada/métodosRESUMO
BACKGROUND: Vulvovaginal atrophy (VVA) includes a wide range of conditions affecting the reproductive and urinary systems, often requiring careful evaluation and management for optimal health. AIMS: This study aims to evaluate the symptom management effects of a real time temperature-monitored non-ablative RF device for the treatment of postmenopausal Chinese women with VVA symptoms. METHODS: This pilot study involved 24 postmenopausal Chinese women with one or more VVA symptoms, who wished to remain sexually active. VHIS, VAS, and FSFI were used to track and evaluate various aspects of the patient's condition. Analyses were conducted at the end of the study to verify the statistical significance of the treatment's results. RESULTS: All patients reported substantial, statistically significant, improvements on every VVA symptom tracked. Approximately 80% of the patients reported total symptom reversal at 12-week post-treatment follow-up. CONCLUSION: This pilot study demonstrated that non-ablative, monopolar RF technology equipped with real time temperature monitoring is feasible and safe in the treatment of postmenopausal women with VVA symptoms, and efficacious at up to 12 weeks post-treatment.
Assuntos
Atrofia , Pós-Menopausa , Vagina , Vulva , Humanos , Feminino , Projetos Piloto , Pessoa de Meia-Idade , Vagina/patologia , Vulva/patologia , Vulva/efeitos da radiação , China , Resultado do Tratamento , Idoso , Doenças Vaginais/terapia , Doenças Vaginais/patologia , Terapia por Radiofrequência/métodos , Terapia por Radiofrequência/efeitos adversos , Terapia por Radiofrequência/instrumentação , Monitorização Fisiológica/métodos , Monitorização Fisiológica/instrumentação , Povo Asiático , População do Leste AsiáticoRESUMO
BACKGROUND: Skin's exposure to intrinsic and extrinsic factors causes age-related changes, leading to a lower amount of dermal collagen and elastin. AIM: This study investigated the effects of a novel facial muscle stimulation technology combined with radiofrequency (RF) heating on dermal collagen and elastin content for the treatment of facial wrinkles and skin laxity. METHODS: The active group subjects (N = 6) received four 20-min facial treatments with simultaneous RF and facial muscle stimulation, once weekly. The control subject (N = 1) was untreated. Skin biopsies obtained at baseline, 1-month and 3-month follow-up were evaluated histologically to determine collagen and elastin fibers content. A group of independent aestheticians evaluated facial skin appearance and wrinkle severity. Patient safety was followed. RESULTS: In the active group, collagen-occupied area reached 11.91 ± 1.80 × 106 µm2 (+25.32%, p < 0.05) and 12.35 ± 1.44 × 105 µm2 (+30.00%, p < 0.05) at 1-month and 3-month follow-up visits. Elastin-occupied area at 1-month and 3-month follow-up was 1.64 ± 0.14 × 105 µm2 (+67.23%, p < 0.05), and 1.99 ± 0.21 × 105 µm2 (+102.80%, p < 0.05). In the control group, there was no significant difference (p > 0.05) in collagen and elastin fibers. Active group wrinkle scores decreased from 5 (moderate, class II) to 3 (mild, class I). All subjects, except the control, improved in appearance posttreatment. No adverse events or side effects occurred. CONCLUSION: Decreased dermal collagen and elastin levels contributes to a gradual decline in skin elasticity, leading to facial wrinkles and unfirm skin. Study results showed noticeable improvement in facial appearance and increased dermal collagen and elastin content subsequent to simultaneous, noninvasive RF, and facial muscle stimulation treatments.
Assuntos
Colágeno , Elastina , Músculos Faciais , Envelhecimento da Pele , Humanos , Elastina/análise , Elastina/metabolismo , Envelhecimento da Pele/efeitos da radiação , Colágeno/metabolismo , Colágeno/análise , Feminino , Pessoa de Meia-Idade , Adulto , Músculos Faciais/efeitos da radiação , Terapia por Radiofrequência/métodos , Terapia por Radiofrequência/efeitos adversos , Masculino , Terapia por Estimulação Elétrica/efeitos adversos , Terapia por Estimulação Elétrica/instrumentação , Terapia por Estimulação Elétrica/métodos , Técnicas Cosméticas/efeitos adversos , Técnicas Cosméticas/instrumentação , Pele/efeitos da radiação , Pele/patologia , Face , Biópsia , Resultado do TratamentoRESUMO
BACKGROUND: Striae distensae (SD) is a challenging cosmetic condition. Ablative fractional laser (AFL) is an effective method for treating SD. Recently, fractional radiofrequency (FRF) has been shown to be a promising treatment for SD; however, few studies have shown the differences between FRF and AFL in the treatment of SD. AIMS: This study aimed to evaluate and compare the clinical efficacy and safety of bipolar FRF with 2940-nm erbium yttrium aluminum garnet (Er:YAG) AFL in the treatment of SD. PATIENTS/METHODS: Twenty volunteers with abdominal SD were enrolled in this study. One half of the abdomen was treated with 2940-nm Er:YAG AFL, whereas the other half was treated with bipolar FRF, with three sessions at 4-week intervals. Photographic evaluations of clinical improvement were conducted by two independent investigators before and after treatment, and the patients provided self-assessments. Two participants underwent three punch biopsies, one before treatment and two obtained from bilateral representative skin lesions on the abdomen 3 months following the final treatment. RESULTS: Clinical improvements were observed in SD on both sides of the abdomen after the two treatments. Post-treatment skin biopsies revealed increased thickness in the epidermis and dermis, and higher collagen and elastin density compared to those at the baseline. No statistically significant differences were observed in the clinical outcomes between the two treatment approaches. CONCLUSIONS: The efficacy and safety of bipolar FRF treatment are comparable to those of 2940-nm Er:YAG AFL treatment, providing an alternative and effective treatment for SD.
Assuntos
Lasers de Estado Sólido , Estrias de Distensão , Humanos , Estrias de Distensão/terapia , Lasers de Estado Sólido/uso terapêutico , Lasers de Estado Sólido/efeitos adversos , Feminino , Adulto , Resultado do Tratamento , Adulto Jovem , Masculino , Abdome , Pele/efeitos da radiação , Pele/patologia , Terapia por Radiofrequência/efeitos adversos , Terapia por Radiofrequência/métodos , Terapia por Radiofrequência/instrumentação , Biópsia/efeitos adversos , Satisfação do PacienteRESUMO
OBJECTIVES: Lumbosacral radicular pain (LRP) is one of the most common causes of neuropathic pain. This pain often arises from inflammation in the dorsal root ganglia (DRG) or spinal nerves. Despite various treatment modalities, success rates are not very high in chronic LRP cases. Pulsed radiofrequency (PRF) therapy, frequently applied to the DRG, is widely used, but its effectiveness is often questioned in various studies. The primary aim of our study is to evaluate the effectiveness of PRF treatment in 154 patients. METHODS: Patients with LRP for longer than 3 months, treated with PRF, were included in this study. To assess the efficacy of PRF treatment, numerical rating scale (NRS) scores were evaluated at the 4th-week and 6th-month follow-ups. RESULTS: The NRS scores were significantly lower at the 4th-week and 6th-month follow-ups compared to pre-treatment levels (p<0.001). However, there was no significant difference between the mean NRS scores at the 4th week and 6th month. CONCLUSION: Success in interventional pain procedures is often considered as at least a 50% reduction in pain scores. The success rate for PRF treatment for LRP in the literature varies between 30% and 60%, which is similar to our findings at the 4th week and 6th month. PRF treatment is widely used due to its low side-effect profile and cost-effectiveness in the long term. There is no fully standardized practice regarding procedural aspects, such as the duration of the application, and prospective studies with larger participation are needed.
Assuntos
Neuralgia , Tratamento por Radiofrequência Pulsada , Terapia por Radiofrequência , Humanos , Estudos Prospectivos , Terapia por Radiofrequência/efeitos adversos , Tratamento por Radiofrequência Pulsada/efeitos adversos , Tratamento por Radiofrequência Pulsada/métodos , Neuralgia/etiologia , Gânglios Espinais , Resultado do TratamentoRESUMO
La hernia diafragmática (HD) es la protrusión de los tejidos abdominales a la cavidad torácica secundaria a un defecto en el diafragma. Tras una revisión de la bibliografía, únicamente se han identificado 44 referencias al respecto, donde se describen 35 casos de HD secundarias a tratamientos percutáneos con radiofrecuencia (RF). En su gran mayoría son secundarias a lesiones por carcinoma hepatocelular en los segmentos V y VIII. No obstante, hasta la fecha, este es el primer caso comunicado de HD tras RF para el tratamiento de una metástasis hepática por carcinoma colorrectal. Las complicaciones secundarias a las HD son muy diversas. El principal factor de riesgo para ello es su contenido; así se describen casos incarceración de colon e intestino delgado. Igualmente, se describen casos asintomáticos en los que la HD ha sido un hallazgo en el seguimiento de los pacientes. El mecanismo fisiopatológico no está del todo esclarecido, pero se especula con la posibilidad de un daño térmico locorregional. Dado que la mayoría de las comunicaciones corresponden a casos sintomáticos y/o tratados, probablemente la incidencia esté infraestimada. No obstante, debido al advenimiento de los tratamientos percutáneos, esta complicación podría verse comunicada en mayor número en los próximos años. Respecto a los tratamientos descritos, en la mayoría de los casos se ha optado por una herniorrafia primaria, con una vía de abordaje abierta o laparoscópica a discreción del cirujano. No se dispone de evidencia que apoye ninguna actitud al respecto, si bien parece claro que el tratamiento quirúrgico es el único definitivo y el de elección en caso de complicación. Sin embargo, en pacientes asintomáticos en quienes la HD sea un hallazgo radiológico de control, el manejo quizá deba guiarse por el estado general del paciente, así como los riesgos potenciales de complicación (contenido, diámetro del orificio herniario ). (AU)
A diaphragmatic hernia is the protrusion of abdominal tissues into the thoracic cavity secondary to a defect in the diaphragm. Reviewing the literature, we found only 44 references to diaphragmatic hernia secondary to percutaneous radiofrequency treatment. The vast majority of these cases were secondary to the treatment of hepatocellular carcinoma in segments V and VIII. Nevertheless, to date, this is the first reported case of diaphragmatic hernia after radiofrequency ablation of a liver metastasis from colorectal cancer. Complications secondary to diaphragmatic hernias are very diverse. The principal risk factor for complications is the contents of the hernia; when small bowel or colon segments protrude in the thoracic cavity, they can become incarcerated. Asymptomatic cases have also been reported in which the diaphragmatic hernia was discovered during follow-up. The pathophysiological mechanism is not totally clear, but it is thought that these diaphragmatic hernias might be caused by locoregional thermal damage. Given that most communications correspond to asymptomatic and/or treated cases, it is likely that the incidence is underestimated. However, due to the advent of percutaneous treatments, this complication might be reported more often in the future. Most cases are treated with primary herniorrhaphy, done with a laparoscopic or open approach at the surgeon's discretion; no evidence supports the use of one approach over the other. Nevertheless, it seems clear that surgery is the only definitive treatment, as well as the treatment of choice if complications develop. However, in asymptomatic patients in whom a diaphragmatic hernia is discovered in follow-up imaging studies, management should probably be guided by the patient's overall condition, taking into account the potential risks of complications (contents, diameter of the opening into the thoracic cavity ). (AU)
Assuntos
Humanos , Masculino , Idoso , Hérnia Diafragmática/diagnóstico por imagem , Hérnia Diafragmática/etiologia , Terapia por Radiofrequência/efeitos adversos , Neoplasias Hepáticas/radioterapia , Metástase NeoplásicaRESUMO
BACKGROUND: Fractional radiofrequency (FRF) is increasingly used for acne scars. The common coexistence of acne scars and active acne is a challenge in the timely management of acne scarring. AIMS: We conducted a systematic review and meta-analysis to compare the efficacy and safety of FRF treatment with the lasers for acne and/or acne scars. METHODS: A systematic search was performed on PubMed, Embase, Ovid, Cochrane Library, and Web of Science. Compared with the lasers, a meta-analysis was conducted to assess the clinical improvement and adverse events after FRF treatment. RESULTS: Eight randomized controlled trials were included. FRF group was more effective than the laser group in patient-evaluated acne improvement (RR = 1.35, 95% CI: 1.01 â¼ 1.80). Regardless of observer assessment or patient evaluation, the FRF group was as effective as the laser group in treating atrophic acne scars (RR = 0.92, 95% CI: 0.78 â¼ 1.08; RR =1.15, 95% CI: 0.99 â¼ 1.34). Although there was no difference in pain level and crusting time between the two groups (SMD =0.20, 95% CI: -0.72 â¼ 1.12; SMD = -0.93, 95% CI: -2.38 â¼ 0.52), PIH incidence of FRF was significantly lower than that of the laser group (RR = 0.12, 95% CI: 0.04 â¼ 0.35). The duration of erythema after FRF treatment was also obviously shorter than that after the laser treatment (SMD = -0.78, 95% CI: -1.37 â¼ -0.18). Subgroup analysis showed that at least a 12-week follow-up was required to observe the full effects of FRF. CONCLUSIONS: FRF could be a better choice for atrophic acne scar patients with active acne. FRF is superior in treating atrophic acne scar patients prone to pigmentation.
Assuntos
Acne Vulgar , Terapia por Radiofrequência , Humanos , Cicatriz/etiologia , Cicatriz/terapia , Cicatriz/patologia , Acne Vulgar/complicações , Acne Vulgar/terapia , Terapia por Radiofrequência/efeitos adversos , Ondas de Rádio/efeitos adversos , Eritema/etiologia , Atrofia/complicaçõesRESUMO
BACKGROUND: Submental skin laxity becomes a common cosmetic problem with age. Bipolar radiofrequency is a new, non-invasive procedure. Unlike the LASER, the radiofrequency (RF) device has no specific chromophore absorption. Thus, the device can be used on any skin type. OBJECTIVE: To evaluate the effectiveness and adverse effects of the bipolar RF for treatment of submental laxity and skin tightening. MATERIAL AND METHODS: Twenty-two patients with submental laxity were treated with Forma™ on both sides of the submental area. The patients underwent four sessions every 2 weeks for one and half months. Two blinded dermatologists evaluated the pre-treatment and post-treatment photographs at every visit. The three-dimensional photographs were recorded by Vectra® camera and determined the association. RESULTS: All 22 patients completed all the treatment sessions. The degree of improvement was statically significant after the third session based on the physical assessment scale and after the second session in terms of the submental laxity score. The fat volume reduction was statically significant from one week to six months from baseline. Almost all subjects developed transient erythema immediately after the treatment. No serious side effects were noted. CONCLUSIONS: The bipolar RF device is another potential choice for skin tightening due to its efficacy and safety profile. It can be used with any skin type and has few side effects.
Assuntos
Técnicas Cosméticas , Terapia por Radiofrequência , Envelhecimento da Pele , Humanos , Técnicas Cosméticas/efeitos adversos , Terapia por Radiofrequência/efeitos adversos , Pescoço , Ondas de Rádio/efeitos adversos , Resultado do Tratamento , Satisfação do PacienteRESUMO
BACKGROUND: The clinical utility of radiofrequency (RF) in patients with knee osteoarthritis (OA) remains unclear. We conducted a meta-analysis to systematically evaluate the efficacy and safety of RF treatment in patients with knee OA. METHODS: Searches of the PubMed, Web of Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Data databases were performed through August 30, 2021. The major outcomes from published randomized controlled trials (RCTs) involving patients with knee OA were compared between RF and control groups, including Visual Analogue Scale (VAS) or Numerical Rating Scale (NRS) scores, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Oxford Knee Score (OKS), Global Perceived Effect (GPE) scale, and adverse effects at available follow-up times. RESULTS: Fifteen RCTs involving 1009 patients were included in this meta-analysis, and the results demonstrated that RF treatment correlated with improvements in pain relief (VAS/NRS score, all P < 0.001) and knee function (WOMAC, all P < 0.001) at 1-2, 4, 12, and 24 weeks after treatment as well as patients' degree of satisfaction with treatment effectiveness (GPE scale, 12 weeks, P < 0.001). OKSs did not differ significantly between the two groups. Moreover, treatment with RF did not significantly increase adverse effects. Subgroup analysis of knee pain indicated that the efficacy of RF treatment targeting the genicular nerve was significantly better than intra-articular RF at 12 weeks after treatment (P = 0.03). CONCLUSIONS: This meta-analysis showed that RF is an efficacious and safe treatment for relieving knee pain and improving knee function in patients with knee OA.
Assuntos
Osteoartrite do Joelho/terapia , Manejo da Dor , Terapia por Radiofrequência/efeitos adversos , Humanos , Articulação do Joelho , Osteoartrite do Joelho/complicações , Manejo da Dor/métodos , Medição da Dor , Terapia por Radiofrequência/métodos , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do TratamentoRESUMO
The presence of a neobladder constitutes a limitation for the radiation oncologist, as there is no clear evidence about its tolerance to radiotherapy (RT). The limited literature only concerns the conventional postoperative treatment in patients with bladder cancer after cystectomy. Here we report a case of a patient with neobladder who underwent a stereotactic RT for a pelvic recurrence of disease, with response to treatment and no toxicity to the neobladder. This case represents a promising example of the chance to perform RT with ablative intent, using advanced techniques, even on lesions close to the neobladder.
Assuntos
Cuidados Pós-Operatórios , Terapia por Radiofrequência , Neoplasias da Bexiga Urinária/radioterapia , Tomada de Decisão Clínica , Cistectomia/efeitos adversos , Cistectomia/métodos , Gerenciamento Clínico , Humanos , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Estadiamento de Neoplasias , Tratamentos com Preservação do Órgão , Órgãos em Risco , Pelve/efeitos da radiação , Terapia por Radiofrequência/efeitos adversos , Terapia por Radiofrequência/métodos , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Neoplasias da Bexiga Urinária/complicações , Neoplasias da Bexiga Urinária/diagnóstico , Neoplasias da Bexiga Urinária/cirurgiaRESUMO
BACKGROUND: Radiofrequency (RF) and high-intensity focused electromagnetic (HIFEM) technologies are used for noninvasive body shaping as standalone modalities. OBJECTIVE: To examine the effects of novel synchronized RF and HIFEM on subcutaneous adipose tissue in a porcine animal model. MATERIALS AND METHODS: Seven large white pigs aged 6 months received 3 abdominal treatments of simultaneous application of synchronized RF and HIFEM (30 minutes, once per week). Punch biopsies of treated and control subcutaneous tissue were collected at the baseline, 4 days, 2 weeks, 1 month, and 2 months. Specimens were examined by light and scanning electron microscopy. Adipocyte volume was analyzed. Fat tissue temperature was measured in situ (fiber optic probes) and superficially (thermal imager). RESULTS: Fat layer was heated to temperatures of 42 to 45°C. Signs of fat apoptosis (shape alternations and pyknotic nuclei) appeared at day 4 and peaked between 2 weeks and 1 month. Adipocyte volume decreased significantly (p < .001) by 31.1% at 2 weeks, 1 month (-23.6%), and 2 months (-22.0%). Control samples showed healthy adipocytes. Scanning electron microscopy micrographs corroborated histology findings, showing flattened, volume-depleted and disrupted adipocytes. CONCLUSION: Synchronized RF with HIFEM procedure resulted in a significant and sustained fat reduction with no adverse events.
Assuntos
Contorno Corporal/métodos , Magnetoterapia/métodos , Terapia por Radiofrequência/métodos , Gordura Subcutânea/efeitos da radiação , Adipócitos/efeitos da radiação , Adipócitos/ultraestrutura , Animais , Contorno Corporal/efeitos adversos , Contorno Corporal/instrumentação , Terapia Combinada/instrumentação , Terapia Combinada/métodos , Feminino , Temperatura Alta/efeitos adversos , Magnetoterapia/efeitos adversos , Magnetoterapia/instrumentação , Microscopia Eletrônica , Modelos Animais , Terapia por Radiofrequência/efeitos adversos , Terapia por Radiofrequência/instrumentação , Gordura Subcutânea/citologia , Gordura Subcutânea/ultraestrutura , SuínosRESUMO
BACKGROUND: Radiofrequency and high-Intensity Focused Electromagnetic (HIFEM) field procedure are well-known, stand-alone, body-shaping modalities, yet their simultaneous application has not been investigated. OBJECTIVE: The aim is to evaluate the efficacy of a novel device simultaneously delivering HIFEM and radiofrequency for subcutaneous fat reduction and muscle toning. MATERIALS AND METHODS: Forty-one subjects with an average age of 39.7 ± 11.5 years were recruited. The subjects received 3 abdominal treatments (one per week). Magnetic resonance imaging images of the treated area were evaluated at baseline and at 1-, 3-, and 6-month visits for changes in subcutaneous fat, muscle thickness, and abdominal separation (AS). Anthropometric data and digital photographs were collected. Subject satisfaction and therapy comfort were evaluated. RESULTS: The muscle mass increase peaked at 3 months, showing 26.1% thickening. The fat thickness reduction was most prominent at 3 months, showing a 30.8% reduction. The AS decreased by 18.8% at 3 months after treatment. The waist circumference reduced by 5.87 ± 3.64 cm at a 3-month follow-up. Six-month data showed maintenance of these outcomes. The treatment was considered as comfortable with high patient satisfaction. CONCLUSION: The analysis of magnetic resonance imaging images and waist measurements showed that the therapy combining HIFEM and radiofrequency is highly effective in reducing subcutaneous fat and muscle thickening.
Assuntos
Gordura Abdominal , Contorno Corporal/métodos , Magnetoterapia , Tono Muscular , Terapia por Radiofrequência , Gordura Abdominal/diagnóstico por imagem , Adulto , Contorno Corporal/efeitos adversos , Feminino , Humanos , Magnetoterapia/efeitos adversos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Terapia por Radiofrequência/efeitos adversos , Resultado do TratamentoRESUMO
Hyperhidrosis (HH) is defined as perspiration beyond the level required to maintain temperature regulation. HH affects nearly 4.8% of the population in the United States. It can have a great impact on patient’s quality of life by disturbing daily activity, performance, confidence, social interactions, and mental health. In the majority of patients with HH (93%), the etiology of excess sweating is idiopathic, which classifies it as primary focal HH. Mild HH may be controlled with topical antiperspirants and lifestyle modifications. Based on the location of involvement, iontophoresis and botulinum toxin may be considered if the patient does not respond to topical therapies. Despite minimizing sweating, chronic use of systemic anticholinergics, in particular oxybutynin, may result in detrimental adverse effects such as dementia. Local surgery, radiofrequency, microwave, and lasers are other potential modalities for HH. Sympathectomy can be a last resort for the treatment of focal HH of the palmar, plantar, axillary, and craniofacial areas after failure of less invasive therapeutic options. In this review, we conducted a comprehensive search in the PubMed electronic database to summarize an algorithmic approach for the treatment of HH. This can help broaden options for managing this difficult disease. J Drugs Dermatol. 20(5): doi:10.36849/JDD.5774.
Assuntos
Dermatologia/métodos , Hiperidrose/terapia , Glândulas Sudoríparas/fisiopatologia , Antiperspirantes , Toxinas Botulínicas Tipo A/administração & dosagem , Toxinas Botulínicas Tipo A/efeitos adversos , Antagonistas Colinérgicos/administração & dosagem , Antagonistas Colinérgicos/efeitos adversos , Terapia Combinada/métodos , Dermatologia/normas , Humanos , Hiperidrose/diagnóstico , Hiperidrose/etiologia , Hiperidrose/psicologia , Iontoforese/métodos , Terapia a Laser/métodos , Guias de Prática Clínica como Assunto , Qualidade de Vida , Terapia por Radiofrequência/efeitos adversos , Terapia por Radiofrequência/instrumentação , Terapia por Radiofrequência/métodos , Índice de Gravidade de Doença , Glândulas Sudoríparas/efeitos dos fármacos , Glândulas Sudoríparas/efeitos da radiação , Simpatectomia , Resultado do TratamentoAssuntos
Axila/diagnóstico por imagem , Hiperidrose/terapia , Micro-Ondas/uso terapêutico , Terapia por Radiofrequência/métodos , Glândulas Sudoríparas/efeitos da radiação , Axila/irrigação sanguínea , Axila/inervação , Humanos , Hiperidrose/psicologia , Injeções Intralesionais/efeitos adversos , Odorantes , Terapia por Radiofrequência/efeitos adversos , Terapia por Radiofrequência/instrumentação , Autoimagem , Resultado do Tratamento , Ultrassonografia de Intervenção , Veias/diagnóstico por imagem , Veias/lesõesRESUMO
BACKGROUND: Aging of the face and upper neck is a complex process characterized by loss of collagen and elastic fibers, resulting in clinical skin laxity. Noninvasive interventions such as monopolar capacitively coupled radiofrequency (MRF) have gained popularity, offering a safer and more convenient alternative to traditional surgical face lift. The latest MRF device features larger tips, vibration, cooling, and impedance matching. OBJECTIVE: We performed the first open-label clinical trial, measuring the efficacy, safety, and patient satisfaction of this device for noninvasive lifting and tightening of the face and upper neck. MATERIALS AND METHODS: Forty subjects 30 to 60 years of age with mild/moderate skin laxity of the face and upper neck were enrolled. After pretreatment with ketorolac 60 mg intramuscular injection, subjects underwent treatment with MRF. Follow-up evaluations were performed on Days 30, 60, and 180. RESULTS: Our study demonstrated that the newest generation MRF produced statistically significant improvement in skin laxity 6 months post-treatment, especially in the jowls and melolabial folds. According to the Investigator Global Aesthetic Improvement Score, 73% of subjects had improvement at 6 months post-treatment. Subject satisfaction and improvement questionnaires supported these findings. CONCLUSION: Our data coupled with the excellent adverse effect profile validates MRF as an attractive treatment modality for facial and upper neck skin laxity.
Assuntos
Técnicas Cosméticas/instrumentação , Terapia por Radiofrequência/instrumentação , Ritidoplastia/instrumentação , Adulto , Técnicas Cosméticas/efeitos adversos , Estética , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pescoço , Satisfação do Paciente , Terapia por Radiofrequência/efeitos adversos , Terapia por Radiofrequência/métodos , Ritidoplastia/efeitos adversos , Ritidoplastia/métodos , Envelhecimento da Pele/efeitos da radiação , Resultado do TratamentoRESUMO
BACKGROUND: Skin rejuvenation can be achieved with minimally invasive treatments using energy-based devices that feature reduced side effects and downtime. Post-treatment care is key to minimize any potential side effects and skin reactions such as erythema, dryness, or dyschromia. OBJECTIVE: The objective of this study was to evaluate the efficacy and patient satisfaction of a novel carboxytherapy gel mask compared with petroleum-based lanolin-containing ointment to accelerate wound healing facial post-nanofractional radiofrequency treatment. METHODS AND MATERIALS: Ten subjects were enrolled in this pilot, prospective, randomized, single-blind study and randomized into two arms. One arm received one nanofractional radiofrequency treatment with ointment right after and four consecutive days of ointment applications twice a day, while the second arm followed this regimen with a carboxytherapy gel mask application right after and four consecutive days after treatment. Investigator, safety, and patient assessments were conducted at 24 hours and one-week post treatment. Safety was monitored throughout. The primary endpoint was defined as the degree of investigator global assessment (IGA) in photodamage, pigmentation, and wrinkles using standardized photographs. Secondary endpoints included investigator-rated degree of erythema, edema, crusting, exudation, percentage healing, improvement of skin quality, and patient satisfaction. RESULTS: Nine patients completed the study. There was improvement of one degree in IGA for photodamage, pigmentation and wrinkles in all patients using the carboxytherapy gel mask at the one-week follow up. Blinded investigator ratings showed significant improvement of dryness, erythema, edema, crusting, and percentage healing at the 24-hour follow up, with all patients remaining the same a week post treatment. All patients in the carboxytherapy group were satisfied with the treatment and had no adverse effects. Three patients in the petroleum-based lanolin-containing group experienced mild edema and acne breakout that resolved two weeks after treatment. CONCLUSION: Carboxytherapy delivered via a gel mask after skin rejuvenation procedures is a safe and effective strategy to improve clinical outcomes and reduce post-treatment side effects. J Drugs Dermatol. 20(4):461-465. doi:10.36849/JDD.5856.