A pandemic agreement is within reach.

At the end of May, 194 member states of the World Health Organization (WHO) will meet for the World Health Assembly. Negotiations underway now will determine whether they vote then to adopt a pandemic agreement. For the past 2 years, discussions have focused on articulating essential components of a robust and equitable architecture for pandemic preparedness and response. Despite this, talks have failed to produce sufficient consensus on a detailed draft, prompting the intergovernmental negotiating body to propose a "streamlined" version. The new text, released on 16 April, consolidates provisions for research and development, technology transfer, pathogen access and benefit sharing (including pandemic products such as medicines and vaccines), with many particulars deferred to future procedures. Ultimately, success of the agreement will depend on these details and implementation. Nevertheless, member states shouldn't bypass the consensus reached to date, but continue progress to adopt this agreement.

An mRNA technology transfer programme and economic sustainability in health care.

The World Health Organization (WHO) set up the messenger ribonucleic acid (mRNA) technology transfer programme in June 2021 with a development hub in South Africa and 15 partner vaccine producers in middle-income countries. The goal was to support the sustainable development of and access to life-saving vaccines for people in these countries as a means to enhance epidemic preparedness and global public health. This initiative aims to build resilience and strengthen local vaccine research, and development and manufacturing capacity in different regions of the world, especially those areas that could not access coronavirus disease 2019 (COVID-19) vaccines in a timely way. This paper outlines the current global vaccine market and summarizes the findings of a case study on the mRNA technology transfer programme conducted from November 2022 to May 2023. The study was guided by the vision of the WHO Council on the Economics of Health for All to build an economy for health using its four work streams of value, finance, innovation and capacity. Based on the findings of the study, we offer a mission-oriented policy framework to support the mRNA technology transfer programme as a pilot for transformative change towards an ecosystem for health innovation for the common good. Parts of this vision have already been incorporated into the governance of the mRNA technology transfer programme, while other aspects, especially the common good approach, still need to be applied to achieve the goals of the programme.

L'Organisation mondiale de la Santé (OMS) a lancé le Programme de transfert de la technologie de l'acide ribonucléique messager (ARNm) en juin 2021, assorti d'un centre de développement en Afrique du Sud et de 15 fabricants de vaccins partenaires dans des pays à revenu intermédiaire. L'objectif consistait à soutenir la pérennisation et l'accès à des vaccins d'importance vitale pour les populations de ces pays en vue d'améliorer la préparation aux épidémies et la santé publique mondiale. Cette initiative vise à accroître la résilience et à renforcer la recherche vaccinale locale, ainsi que les capacités de conception et de fabrication dans différentes régions du monde, en particulier dans celles qui n'ont pas pu obtenir des vaccins contre la maladie à coronavirus 2019 (COVID-19) en temps utile. Le présent document décrit l'actuel marché mondial des vaccins et résume les résultats d'une étude de cas consacrée au Programme de transfert de la technologie ARNm et menée de novembre 2022 à mai 2023. L'étude s'inspire de la vision du Conseil de l'OMS sur l'économie de la santé pour tous, qui consiste à construire une économie allant dans le sens de la santé selon quatre axes de travail: valeur, finances, innovation et capacité. En nous fondant sur les résultats de l'étude, nous proposons un cadre stratégique orienté vers un but précis: soutenir le Programme de transfert de la technologie ARNm en tant que projet pilote afin d'évoluer vers un écosystème d'innovation en matière de santé dédié au bien commun. Certains aspects de cette vision ont déjà été intégrés dans les principes de gouvernance du Programme de transfert de la technologie ARNm tandis que d'autres, en particulier l'approche liée au bien commun, doivent encore être appliqués pour atteindre les objectifs du programme.

La Organización Mundial de la Salud (OMS) creó el programa de transferencia de tecnología de ácido ribonucleico mensajero (ARNm) en junio de 2021 con un centro de desarrollo en Sudáfrica y 15 productores de vacunas asociados en países de ingresos medios. El objetivo era apoyar el desarrollo sostenible y el acceso a las vacunas que salvan vidas para la población de estos países como medio para mejorar la preparación ante epidemias y la salud pública mundial. Con esta iniciativa se pretende crear resiliencia y reforzar la capacidad local de investigación, desarrollo y fabricación de vacunas en distintas regiones del mundo, especialmente en aquellas áreas que no pudieron acceder oportunamente a las vacunas contra la enfermedad por coronavirus de 2019 (COVID-19). Este documento describe el actual mercado mundial de vacunas y resume las conclusiones de un estudio de caso sobre el programa de transferencia de tecnología de ARNm realizado entre noviembre de 2022 y mayo de 2023. El estudio se guió por la visión del Consejo de la OMS sobre la Economía de la Salud para Todos de crear una economía de la salud utilizando sus cuatro líneas de trabajo: valor, financiación, innovación y capacidad. A partir de las conclusiones del estudio, ofrecemos un marco político orientado a la misión para apoyar el programa de transferencia de tecnología de ARNm como piloto para un cambio transformador hacia un ecosistema de innovación sanitaria para el bien común. Algunas partes de esta visión ya se han incorporado a la gobernanza del programa de transferencia de tecnología de ARNm, mientras que otros aspectos, en especial el enfoque del bien común, aún deben aplicarse para alcanzar los objetivos del programa.

Technology transfer for green investments: exploring how technology transfer through foreign direct investments can contribute to sustainable practices and reduced environmental impact in OIC economies.

Estimating the asymmetrical influence of foreign direct investment is the primary goal of the current study. In addition, further controlled variables affect environmental degradation in OIC nations. Due to this, current research employs the asymmetric (NPARDL) approach and the data period from 1980 to 2021 to estimate about viability of the EKC (environmental Kuznets curve) theory. The study utilized greenhouse gas (GHG) including emissions of carbon dioxide (CO2), nitrous oxide (N2O), methane (CH4), and ecological footprint as substantial parameters of environmental quality. A nonlinear link between foreign direct investments, trade openness, economic growth, urbanization, energy consumption, and environmental pollution with CO2, N2O, CH4, and ecological footprint in the OIC nations is confirmed by the study's outcomes, which however reveals inconsistent results. Furthermore, the results also show that wrong conclusions might result from disregarding intrinsic nonlinearities. The study's conclusions provide the most important recommendations for decision-makers.

Organizational Network Analysis of SAMHSA's Technology Transfer Center (TTC) Network.

Technology transfer centers (TTCs) facilitate the movement of evidence-based practices in behavioral healthcare from theory to practice. One of the largest such networks is the Substance Abuse and Mental Health Services Administration's (SAMHSA) TTC Network. This brief report shares findings from an organizational network analysis (ONA) of the network conducted as part of an external evaluation. For non-supervisory TTCs (n = 36) across three focus areas (addiction, prevention, and mental health), the authors computed network density, harmonic closeness, and non-null dyadic reciprocity for five types of interactions (e.g., "collaborated in workgroups"), then, for each interaction type, used Welch's T-test to compare mean harmonic closeness of standalone TTC grantees versus multiple-TTC grantees. ONA identified potentially isolated regional TTCs as well as mismatches between some centers' desired scope and their network centrality and enabled investigation of broader questions around behavioral health support systems. The approach appears useful for evaluating TTCs and similar support networks.

Evaluation framework for facilitating the technology transfers of universities: Focusing on the perspective of technology donors.

Technological innovation and preoccupation with new markets through technological innovation have become critical factors in achieving success in the global market. Currently, companies cannot develop and commercialize all technologies. Therefore, the importance of technology transfers is rapidly increasing. Technology transfer is a crucial strategy adopted by organizations to remain innovative and competitive. However, Korea's technology transfer rate is only 37.9%. In particular, the technology transfer rate from universities to companies is lower than that from government-funded research institutes in Korea. Although the fundamental approach for resolving barriers to technology transfer have been studied, previous research has been conducted from a narrow definition of technology transfer. Furthermore, previous research has focused on analyzing the success factors of technology transfer, presenting technology transfer processes, or conducting case studies. Therefore, it is necessary to develop a technology donor diagnosis framework based on CSFs (Critical Success Factors) to eliminate obstacles to technology transfers. To lower the barriers to technology transfers, it is necessary to develop a strategy for a successful technology transfer based on the diagnosis of technology donors. This study develops a diagnosis framework for universities from the perspective of technology donors, implements and tests the framework using case studies, and proposes strategies for each stage of technology transfer growth. The framework is able to assess multidimensional perspectives, because CSFs and PMs were extracted based on BSC. Furthermore, by comparing the perspectives score of technology donors in different universities, technology donors can identify the areas in which each university is lacking in its current situation. Multidimensional diagnosis and aggregation score of technology donors offer to extract optimal CSFs for technology transfer activation for each growth stage.

Maturity assessment of software-driven medical technologies: a quantitative score derived from a quality standard for the research phase.

Quantitatively assessing the level of readiness of medical technology improves its chance of successfully transfer from research to industry but remains a challenge. As many innovative medical devices are associated with or incorporate software, this article presents a methodology for evaluating the software maturity of a "Software-driven Medical Technology" (SdMT) during the research phase. A technological maturity model is developed by methodologically extracting relevant terms from the ISO/IEC 62304 standard, the main industry standard for medical device software, and results in a list of required software engineering artifacts. This list and the relative weight of the artifacts are used to establish a software maturity score for SdMT and the corresponding assessment questionnaire. The consistency of the model is demonstrated by analyzing the obtained score system relatively with the standard. The maturity score of a SdMT can be assessed during the research phase and depends on the number and importance of the artifacts already present at the time of evaluation.Clinical relevance- The proposed quantitative maturity score can help the medical technology innovation actors (clinicians, researchers and industrials) to better identify, improve and fasten the readiness of technology for clinical investigation and technology transfer.

Key considerations for the development of novel mRNA candidate vaccines in LMICs: A WHO/MPP mRNA Technology Transfer Programme meeting report.

The WHO/MPP mRNA Technology Transfer Programme, initiated in 2021, focuses on establishing mRNA vaccine manufacturing capacity in LMICs. On 17-21 April 2023, Programme partners were convened to review technology transfer progress, discuss sustainability aspects and promote mRNA product development for diseases relevant to LMICs. To help guide product development, this report introduces key considerations for for understanding the likelihood of technical and regulatory success and of policy development and procurement for mRNA vaccines to be developed and manufactured in LMICs. The report underscores the potential for LMICs to establish sustainable mRNA R&D pipelines.

Algorithms at the Gate-Radiology's AI Adoption Dilemma.

In this Viewpoint a radiologist surveys the ascent of artificial intelligence (AI) in imaging and what the future likely holds for AI in this discipline.

Technology transfer during the COVID-19 pandemic: report on the first face-to-face practical training course in Brazil.

MAIN RESULTS: Technology transfer can take place at large events, as long as safety protocols are strictly enforced. It is important to disseminate, at these events, the concepts of the Responsible Research and Innovation (RRI). Implications for services: Face-to-face training course is fundamental for training public health professionals. Technology transfer between research institutions and health services results in updating and improving health system performance. PERSPECTIVES: Based on the success of the reported technology transfer, a new module will be incorporated into the next edition of VEME (Panama 2022), entitled Virus Evolution to Public Health Policy Makers. The objective of this report was to describe the first face-to-face course aimed at training public health professionals in performing real-time genomic surveillance during the pandemic period. Experience report on a theoretical-practical course focusing on genomic research and surveillance, including mobile sequencing technologies, bioinformatics, phylogenetics and epidemiological modeling. There were 162 participants in the event and it was the first major face-to-face training course conducted during the COVID-19 epidemic in Brazil. No cases of SARS-CoV-2 infection was detected among the participants at the end of the event, suggesting the safety and effectiveness of all safety measures adopted. The results of this experience suggest that it is possible to conduct professional training safely during pandemics, as long as all safety protocols are followed.

Does high-speed rail stimulate university technology transfer? evidence from China.

Prior studies ignore the impact of infrastructure on university technology transfer. High-speed rail, China's most significant infrastructure, has played an essential role in the economy and society. Using high-speed railway construction as a quasi-experiment and a large sample of Chinese universities for the 2007-2017 period, we investigate the impact of high-speed rail on university technology transfer. We provide extensive evidence that high-speed rail has a positive effect on university technology transfer. The finding remains valid after a battery of robustness tests. Mechanism tests find that high-speed rail can improve university technology transfer by promoting the interaction between universities and enterprises and improving enterprises' technology demand for universities. Further analysis shows that better intellectual property protection strengthens the effect of high-speed rail on university technology transfer, and the relationship between high-speed rail and university technology transfer is more prominent in the regions with underdevelopment technology trading markets. Our study suggests that high-speed rail is an important variable that affects university technology transfer.