RESUMO
In recent years, our knowledge of ovarian sex cord-stromal tumors has increased, and their classification has evolved. In this review, recent advances in the classification and pathology of ovarian sex cord-stromal tumors are discussed, and the controversy regarding the classification of sex cord tumor with annular tubules is addressed. The current classification is built on those of the past, and future classifications should improve on what is now in place incorporating new knowledge from more sophisticated clinicopathologic studies and advanced molecular techniques. This review emphasizes articles written in the 21st century as well as those that have significantly advanced our knowledge of sex cord-stromal tumors in past decades. The tumors in this group occur over a wide age range and are often unilateral. In difficult cases, immunocytochemistry provides improved diagnostic accuracy. The most useful immunohistochemical marker for their identification is alpha-inhibin, which is positive in most neoplasms in the sex cord-stromal group. The article concludes with a section discussing the pathogenesis of sex cord-stromal tumors.
Assuntos
Neoplasias Ovarianas/classificação , Neoplasias Ovarianas/patologia , Tumores do Estroma Gonadal e dos Cordões Sexuais/classificação , Tumores do Estroma Gonadal e dos Cordões Sexuais/patologia , Biomarcadores Tumorais/análise , Feminino , Fibroma/classificação , Fibroma/etiologia , Fibroma/patologia , Tumor de Células da Granulosa/classificação , Tumor de Células da Granulosa/etiologia , Tumor de Células da Granulosa/patologia , Humanos , Imuno-Histoquímica , Inibinas/análise , Tumor de Células de Leydig/classificação , Tumor de Células de Leydig/etiologia , Tumor de Células de Leydig/patologia , Luteoma/classificação , Luteoma/etiologia , Luteoma/patologia , Neoplasias Ovarianas/química , Neoplasias Ovarianas/etiologia , Tumores do Estroma Gonadal e dos Cordões Sexuais/química , Tumores do Estroma Gonadal e dos Cordões Sexuais/etiologia , Tumor da Célula Tecal/classificação , Tumor da Célula Tecal/etiologia , Tumor da Célula Tecal/patologiaAssuntos
Neoplasias Ovarianas/patologia , Adolescente , Fatores Etários , Carcinoma de Células Pequenas/epidemiologia , Carcinoma de Células Pequenas/patologia , Criança , Pré-Escolar , Cistadenoma/patologia , Feminino , Tumor de Células da Granulosa/patologia , Humanos , Lactente , Tumor de Células de Leydig/classificação , Tumor de Células de Leydig/patologia , Mesonefroma/patologia , Metástase Neoplásica , Neoplasias Embrionárias de Células Germinativas/patologia , Neoplasias Ovarianas/classificação , Neoplasias Ovarianas/epidemiologia , Tumor de Células de Sertoli/classificação , Tumor de Células de Sertoli/patologia , Teratoma/patologiaRESUMO
The study of 83 cases of testicular tumours in dogs based on the International Histological Classification of tumours in domestic animals (WHO) has shown that these tumours can be divided into three groups: sex cord-stromal tumours (43.3%), germ cell tumours (36.3%) and multiple primary tumours (20.4%). The latter consisted of germ cell and sex cord-stromal components. Choriocarcinomas and teratomas were not found. By morphological criteria and histogenesis testicular tumours in dogs have shown to be very similar to analogous tumours in humans.
Assuntos
Doenças do Cão/patologia , Neoplasias Testiculares/veterinária , Animais , Doenças do Cão/classificação , Cães , Disgerminoma/classificação , Disgerminoma/patologia , Disgerminoma/veterinária , Tumor de Células de Leydig/classificação , Tumor de Células de Leydig/patologia , Tumor de Células de Leydig/veterinária , Masculino , Estudos Retrospectivos , Tumor de Células de Sertoli/classificação , Tumor de Células de Sertoli/patologia , Tumor de Células de Sertoli/veterinária , Neoplasias Testiculares/classificação , Neoplasias Testiculares/patologia , Testículo/patologiaRESUMO
The clinical and pathologic features of 64 Sertoli-Leydig tumors of the ovary with intermediate and poor differentiation were studied. The neoplasms occurred mainly in young women. Fifty-four percent of the patients presented with clinical evidence of a hormonally active tumor, and 38% were virilized. The remaining 46% had nonspecific symptoms. Sixty-two patients had tumors confined to one ovary at operation (Stage Ia), while only two patients presented with pelvic metastases (Stage III). The prognosis was generally favorable; the 5- and 10-year actuarial survival rates were 92%. Unilateral salpingo-oophorectomy was effective treatment for Stage Ia Sertoli-Leydig tumors in young women. Microscopically, 44 of the neoplasms were of intermediate differentiation and 20 were poorly differentiated. Heterologous elements (mucinous epithelium, striated muscle, cartilage) were present in 16 neoplasms. The pathologic features that correspond with development of metastases were poor differentiation, the presence of heterologous mesenchymal elements, frequent mitotic figures in stromal cells, and rupture of the neoplasm.