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1.
Sci Rep ; 11(1): 17891, 2021 09 09.
Artigo em Inglês | MEDLINE | ID: mdl-34504202

RESUMO

Ulnar shortening osteotomy (USO) for ulnar impaction syndrome potentially leads to degenerative changes of the distal radioulnar joint (DRUJ). This study was performed to evaluate the effect of the sigmoid notch morphology on the stress distribution pattern of the DRUJ using computed tomography (CT) osteoabsorptiometry (CT-OAM). We reviewed the pre- and postoperative transverse CT images of 15 wrists that had undergone USO. The examined wrists were classified into two groups based on the sigmoid notch morphology: the linear-type notch (type L) and the curved-type notch (type C). We calculated and statistically compared the percentage of the high-density area (%HDA) in each divided region of the sigmoid notch. In type L, %HDA was significantly larger in the distal-dorsal region of the sigmoid notch before USO. Postoperatively, in type L, no specific regions showed a significantly different %HDA. In type C, %HDA was significantly larger in the distal-volar region of the sigmoid notch before USO. Postoperatively, %HDA of type C was significantly larger in the proximal-volar region. Our results suggest that in patients with ulnar impaction syndrome, morphological evaluation of the sigmoid notch can serve as a predictor of osteoarthritis in the DRUJ with or without USO.


Assuntos
Osteoartrite/cirurgia , Osteotomia , Ulna/cirurgia , Articulação do Punho/fisiopatologia , Articulação do Punho/cirurgia , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite/fisiopatologia , Osteotomia/efeitos adversos , Osteotomia/métodos , Lesões do Manguito Rotador/fisiopatologia , Lesões do Manguito Rotador/cirurgia , Tomografia Computadorizada por Raios X/métodos , Ulna/fisiopatologia
2.
Acta Orthop Traumatol Turc ; 55(2): 107-111, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33847571

RESUMO

OBJECTIVE: This study aims to investigate compensatory rotational movements of the wrist joint in patients with proximal congenital radioulnar synostosis (CRUS), using a valid and reliable three-dimensional (3D) motion analysis technique. METHODS: A total of 26 patients (6 females, 14 males; mean age=15.3 years; and age range=6-32 years) who were diagnosed with unilateral proximal CRUS but were not operated were enrolled in this study. Patients were then categorized into 2 groups: Group I included 5 patients younger than 10 years, and Group II included 15 patients older than 10 years. Eighteen light-reflective skin markers were placed on the bony landmarks of both upper limbs, and both distal forearms were fixed using a U-shaped device to minimize forearm rotation. Each patient grasped the handle of an instrument that used a goniometer to measure wrist rotation; maximal passive pronation and supination angles of the wrist were measured in this manner and also using 3D motion analysis. RESULTS: There was a significant correlation between measurements by the goniometer and 3D motion analysis (r=0.985, p<0.001). The test-retest reliability of the 3D motion analysis was acceptable for both the affected side (ICC=0.992) and the contralateral normal side (ICC=0.997) with low standard measurement errors (1.3° and 0.8°, respectively). Although no significant difference was observed in the range of the wrist rotation between the affected and contralateral sides in Group I (p=0.686), there was a significant difference in the wrist rotation between the affected and contralateral sides in Group II (p=0.001). Further, the pronation angle of the wrist joint was significantly larger in the affected side than that in the contralateral normal side in Group II (p=0.001). CONCLUSION: The 3D motion analysis technique seems to be a valid and reliable method to measure the rotation of the wrist joint. Unilateral proximal CRUS patients older than 10 years of age may develop rotational hypermobility of the wrist joint compared to the contralateral normal side as a compensatory phenomenon. LEVEL OF EVIDENCE: Level III, Diagnostic Study.


Assuntos
Artrometria Articular/métodos , Rádio (Anatomia)/anormalidades , Sinostose , Ulna/anormalidades , Articulação do Punho/fisiopatologia , Adolescente , Feminino , Humanos , Masculino , Rádio (Anatomia)/fisiopatologia , Amplitude de Movimento Articular , Reprodutibilidade dos Testes , Sinostose/diagnóstico , Sinostose/fisiopatologia , Ulna/fisiopatologia
3.
J Orthop Surg Res ; 16(1): 191, 2021 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-33722253

RESUMO

BACKGROUND: Ulnar head fractures are increasingly higher with the growing proportion of the elderly people. Failure to achieve a stable anatomic reduction of ulna head fracture may lead to a distal radioulnar joint (DRUJ) dysfunction and nonunion of the distal radius. Due to the lack of the postoperative reporting outcomes and the biomechanical studies, it has not been well established about the optimal management of the comminuted distal ulna head fracture. Hence, the purpose of this study is to use finite element analysis to explain the advantages and disadvantages of ulnar-side locking plate fixation compared with dorsal-side locking plate fixation and its screw arrangement in the treatment of ulnar head fractures. METHODS: FE models of the ulnar head fracture and the models of ulnar-side locking plate and dorsal-side plate with two or three distal screws was constructed. In order to simulate forces acting on the ulnar and the osteosynthesis material during daily-life activity in subjects who underwent reconstructive surgery, we applied three loading conditions to each model, viz. 20 N axial compression, 50 N axial compression, 1 N∙m torsion moment, 1 N∙m lateral bending moments, and 1 N∙m extension bending moments. Under these conditions, values of the von Mises stress (VMS) distribution of the implant, peak VMS, the relative displacement of the head and shaft fragments between the fracture ends and the displacement and its direction of the models were investigated. RESULTS: The stress values of ulnar-side plates were lower than those of dorsal-side plates. And the ulnar-plate fixation system also has smaller maximum displacement and relative displacement. When adding a screw in the middle hole of the ulnar head, the values of model displacement and the peak stress in fixation system are lower, but it may evidently concentrate the stress on the middle screw. CONCLUSIONS: In conclusion, our study indicated that ulnar-side locking plates resulted in a lower stress distribution in the plate and better stability than dorsal-side locking plates for ulnar head fracture fixation. Adding an additional screw to the ulnar head could increase the stability of the fixation system and provide an anti-torsion function. This study requires clinical confirmation of its practicality in the treatment of ulnar head fractures. This study requires clinical confirmation as to its practicality in the treatment of ulnar head fracture.


Assuntos
Placas Ósseas , Análise de Elementos Finitos , Fixação Interna de Fraturas/métodos , Fraturas Cominutivas/cirurgia , Fraturas da Ulna/cirurgia , Ulna/cirurgia , Idoso , Fenômenos Biomecânicos , Parafusos Ósseos , Feminino , Humanos , Masculino , Estresse Mecânico , Resultado do Tratamento , Ulna/fisiopatologia
4.
Arthroscopy ; 37(5): 1458-1466, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33561484

RESUMO

PURPOSE: To evaluate mid- and long-term outcomes after arthroscopically-assisted transosseous reattachment of the triangular fibrocartilage complex (TFCC) and to analyze the association of distal radioulnar joint (DRUJ) stability with the clinical outcome. METHODS: Patients treated with an arthroscopically-assisted transosseous reattachment of the deep layer of the TFCC between 2000 and 2009 and a minimum follow-up of 12 months at mid-term and 4 years at long-term follow-up were retrospectively reviewed. Mayo Modified Wrist Score (MMWS); Disabilities of the Arm, Shoulder and Hand (DASH) score; pain visual analogue scale (VAS); grip strength and stability of the DRUJ were assessed at 2 follow-up clinical examinations. At the last follow-up, the Patient-Rated Wrist Evaluation score was additionally recorded. RESULTS: Thirty patients with a mean age of 29 (±13) years were included. Most of the patients were female (70%, n = 21). The mid-term evaluation took place at a median of 30 months (range, 12-83 months). The assessed scores showed statistically significant clinical improvement (MMWS, P < .001; DASH score P < .001; VAS P < .001). Stability assessment showed a stable DRUJ in 23 (76.7%) patients. At a median of 106 months (range 52-215 months), the long-term clinical assessment was performed. The evaluated scores demonstrated persisting significant improvement (MMWS P < .001; DASH score P < .001; VAS P < .001). Stability assessment showed a stable DRUJ in 19 patients (63.3%). DRUJ instability did not correlate with clinical outcome. No permanent surgery-related complications occurred. CONCLUSION: Arthroscopically-assisted transosseous reattachment of the deep fibers of radioulnar ligaments leads to excellent and good clinical results in mid- and long-term follow-up. In 95.5% of the analyzed patients, the measured improvement in the DASH score exceeded the in literature reported minimal clinically important difference of 13.5. Loss of DRUJ stability during follow-up was not associated with deterioration of clinical parameters and patient satisfaction. LEVEL OF EVIDENCE: Level IV, retrospective case series.


Assuntos
Artroscopia , Instabilidade Articular/cirurgia , Rádio (Anatomia)/cirurgia , Fibrocartilagem Triangular/cirurgia , Ulna/cirurgia , Articulação do Punho/cirurgia , Adolescente , Adulto , Feminino , Seguimentos , Humanos , Instabilidade Articular/fisiopatologia , Masculino , Pessoa de Meia-Idade , Diferença Mínima Clinicamente Importante , Medição da Dor , Satisfação do Paciente , Rádio (Anatomia)/fisiopatologia , Amplitude de Movimento Articular , Estudos Retrospectivos , Fatores de Tempo , Resultado do Tratamento , Fibrocartilagem Triangular/fisiopatologia , Ulna/fisiopatologia , Escala Visual Analógica , Articulação do Punho/fisiopatologia , Adulto Jovem
5.
Am J Med Genet A ; 185(12): 3531-3540, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-32243688

RESUMO

49,XXXXY is the rarest X and Y chromosomal variation, with an incidence of 1 in 80,000-100,000 live male births and has been associated with numerous musculoskeletal abnormalities. Data was collected from an international cohort of boys with 49,XXXXY over 10 years. Children were evaluated by a multidisciplinary team consisting of a pediatric orthopedist, a neurogeneticist, a neurodevelopmentalist, and two physical therapists. Increased rates of torticollis (32.4%), hamstring tightness (42%), radioulnar synostosis (67.6%), pes planus (65.2%), and other foot abnormalities (86.9%) were observed. Several anomalies increased with age, specifically hamstring tightness, kyphosis, and scoliosis. The elucidation of the orthopedic profile of this population is necessary in order to provide healthcare providers with current medical information. This research further supports the necessity for the comprehensive multidisciplinary treatment of boys with 49,XXXXY.


Assuntos
Cromossomos Humanos X/genética , Síndrome de Klinefelter/diagnóstico , Anormalidades Musculoesqueléticas/diagnóstico , Doenças Raras/diagnóstico , Adolescente , Criança , Pré-Escolar , Cromossomos Humanos Y , Pé Chato/complicações , Pé Chato/diagnóstico , Pé Chato/genética , Pé Chato/fisiopatologia , Tendões dos Músculos Isquiotibiais/diagnóstico por imagem , Tendões dos Músculos Isquiotibiais/fisiopatologia , Humanos , Lactente , Síndrome de Klinefelter/complicações , Síndrome de Klinefelter/genética , Síndrome de Klinefelter/fisiopatologia , Cifose/complicações , Cifose/diagnóstico , Cifose/genética , Cifose/fisiopatologia , Masculino , Anormalidades Musculoesqueléticas/complicações , Anormalidades Musculoesqueléticas/genética , Anormalidades Musculoesqueléticas/fisiopatologia , Rádio (Anatomia)/anormalidades , Rádio (Anatomia)/fisiopatologia , Doenças Raras/complicações , Doenças Raras/genética , Doenças Raras/fisiopatologia , Escoliose/complicações , Escoliose/diagnóstico , Escoliose/genética , Escoliose/fisiopatologia , Sinostose/complicações , Sinostose/diagnóstico , Sinostose/genética , Sinostose/fisiopatologia , Torcicolo/complicações , Torcicolo/diagnóstico , Torcicolo/genética , Torcicolo/fisiopatologia , Ulna/anormalidades , Ulna/fisiopatologia
6.
Biomed Res Int ; 2020: 3056395, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33294437

RESUMO

We aimed to design an individualized intra-articular stabilization device based on 3D printing technology and investigate the clinical effects of this device for treating traumatic instability of the ulnohumeral joint. This study enrolled nine patients with traumatic instability of the ulnohumeral joint (age: 47.2 ± 1.80 years) who received treatment between March 2018 and March 2019 in our hospital. All patients underwent a thin-layer computed tomography (CT) scan of the elbow before surgery. The original injury and repair models of the elbow were printed using 3D printing technology based on CT data. An individualized intra-articular stabilization device was designed with a 2.0 mm Kirschner wire based on the repair model. Nine patients agreed to receive surgical treatment for elbow disease and placement of the intra-articular stabilization device. The nine patients underwent open reduction through a posterior median approach, and the intra-articular stabilization device was placed in the elbow. Operation time, intraoperative blood loss, and postoperative complications were recorded and followed up. The device was removed at two postoperative months, and the Mayo score was used to evaluate elbow function. Four months after removing the intra-articular stabilization device, elbow joint function was evaluated again using the Mayo score. The mean operation time was 100.1 ± 8.2 min, and the mean intraoperative blood loss was 35.5 ± 7.1 ml. No complications occurred after operation. Two months after surgery, eight patients received an excellent Mayo score, and one patient received a good Mayo score. Four months after removal of the intra-articular stabilization device, eight patients received an excellent Mayo score, and one patient received a good Mayo score. The individualized intra-articular stabilization device can increase ulnohumeral stability and achieve rapid functional recovery of the elbow.


Assuntos
Articulação do Cotovelo/fisiopatologia , Úmero/fisiopatologia , Instabilidade Articular/fisiopatologia , Impressão Tridimensional/instrumentação , Ulna/fisiopatologia , Ferimentos e Lesões/fisiopatologia , Adulto , Articulação do Cotovelo/diagnóstico por imagem , Feminino , Humanos , Úmero/diagnóstico por imagem , Instabilidade Articular/complicações , Masculino , Pessoa de Meia-Idade , Desenho de Prótese , Ulna/diagnóstico por imagem , Ferimentos e Lesões/complicações
7.
Clin Biomech (Bristol, Avon) ; 78: 105090, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32562880

RESUMO

BACKGROUND: One of most accepted principles for treating Kienböck's disease before wrist degeneration settles in is to decompress the lunate by an osteotomy. Several osteotomies have been proposed since 1935. However, they are based on biomechanical hypotheses that are sometimes conflicting: This study compares the decompression effect of radius transverse shortening, radius lateral closing and medial closing wedge osteotomies, capitate shortening - with and without hamate shortening - and a Camembert-type radius wedge osteotomy with and without ulnar head shortening according to Sennwald. METHODS: We built a 3D wrist model using finite elements that included the metacarpal, carpal and forearm bones. All wrist ligaments and Triangular Fibrocartilage Complex were incorporated in the simulation. Load was applied on the metacarpals with the forearm bones fixed. We then applied the different osteotomies to the model. FINDINGS: When load was applied to the wrist, the osteotomies that best unloaded the lunate were the capitate shortening osteotomy combined with hamate shortening and the Camembert osteotomy combined with ulna shortening; the latter was the only osteotomy that completely unloaded the lunate. INTERPRETATION: We think the association of the radius Camembert osteotomy and ulna Sennwald's shortening osteotomy is the most effective procedure to propose in Kienböck's disease.


Assuntos
Osso Semilunar/fisiopatologia , Osso Semilunar/cirurgia , Osteonecrose/cirurgia , Osteotomia , Adulto , Artrodese , Fenômenos Biomecânicos , Feminino , Análise de Elementos Finitos , Humanos , Masculino , Osteonecrose/fisiopatologia , Rádio (Anatomia)/fisiopatologia , Rádio (Anatomia)/cirurgia , Ulna/fisiopatologia , Ulna/cirurgia , Suporte de Carga
8.
Clin Biomech (Bristol, Avon) ; 78: 105074, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32562881

RESUMO

BACKGROUND: Simultaneous dislocation of the proximal and distal radio-ulnar joints without bony injuries has been reported, but the mechanism remains unclear. We investigated concurrent proximal and distal radio-ulnar joint instability after sequential sectioning of the annular ligament, triangular fibrocartilage complex, and quadrate ligament. METHODS: We performed this biomechanical study with six fresh-frozen cadaveric upper extremities. Proximal and distal radio-ulnar joint displacement was measured using an electromagnetic tracking device during passive mobility testing with anterior, lateral, and posterior loads on the radial head with pronation, supination, and neutral rotation. Measurements were statistically analyzed using the generalized linear mixed model. FINDINGS: Proximal radio-ulnar joint instability was significantly greater after sectioning of the annular (lateral: 1.4%, P < .05; posterior: 0.7%, P < .05) and quadrate (lateral: 43.7%, P < .05; posterior: 29.5%, P < .05) ligament. Distal radio-ulnar joint instability was significantly greater in every sequential stage (final stage: anterior: 24.1%, P < .05; lateral 21.0%, P < .05; posterior: 31.3%, P < .05). Finally, significant simultaneous instability of the joints was observed after sectioning of the annular ligament, triangular fibrocartilage complex, and quadrate ligament, and neutral rotation potentially induced gross instability. INTERPRETATION: Our ligament injury model induced simultaneous proximal and distal radio-ulnar joint instability without bony or interosseous membrane injury, probably induced by severe soft tissue injury. Proximal radio-ulnar joint instability may influence distal radio-ulnar joint instability from pivoting of the interosseous membrane. Our findings will help surgeons evaluate the magnitude of soft tissue injury and plan surgery for patients with simultaneous proximal and distal radio-ulnar joint instability.


Assuntos
Instabilidade Articular , Fenômenos Mecânicos , Rádio (Anatomia) , Ulna , Adulto , Fenômenos Biomecânicos , Cadáver , Feminino , Humanos , Instabilidade Articular/fisiopatologia , Instabilidade Articular/cirurgia , Ligamentos Articulares/fisiopatologia , Ligamentos Articulares/cirurgia , Masculino , Pessoa de Meia-Idade , Pronação , Rádio (Anatomia)/fisiopatologia , Rádio (Anatomia)/cirurgia , Rotação , Supinação , Ulna/fisiopatologia , Ulna/cirurgia
9.
Medicine (Baltimore) ; 99(19): e19830, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32384428

RESUMO

BACKGROUND: Optimal treatments for ulnar coronoid fracture have yet to be determined. We aimed to systematically review treatment efficacy assessed by functional outcomes of patients with isolated ulnar coronoid fracture. METHODS: Medline, Cochrane Library, EMBASE, and Google Scholar were searched for studies reporting quantitative outcomes data after surgical treatment for isolated ulnar coronoid fractures up to July 16, 2019. Functional outcomes determined using disabilities of the arm, shoulder and hand score; Mayo elbow performance score (MEPS); and range of motion were systematically reviewed. RESULTS: Six studies with a total of 65 patients with isolated coronoid fracture who had received surgical treatment were included. All studies were of good quality according to a modified Delphi checklist. Most patients had Type II fractures based on Regan-Morrey or O'Driscoll classification. Disabilities of the arm, shoulder and hand scores were reported by 2 studies (mean range 5-17). Four studies reported MEPS (mean range 89-98). One study reported Broberg-Morrey scores, in which 93% patients achieved excellent or good outcomes. Five studies reported range of motion, with mean flexion ranging from 122 to 137 and mean extension ranging from 4.0 to 21 degrees. Quantitative analyses revealed that lateral, medial, or posterior approaches in treating Type II fractures are associated with higher postoperative MEPS and flexion scores than the anteromedial approach. CONCLUSIONS: Treatment efficacy assessed by functional outcomes for isolated ulnar coronoid fractures is overall satisfactory. Whether lateral, medial, or posterior approaches lead to more favorable outcomes than the anteromedial approach is inconclusive. Further prospective studies are warranted.


Assuntos
Artroscopia , Desbridamento , Fixação Interna de Fraturas , Fraturas da Ulna , Adolescente , Adulto , Feminino , Humanos , Masculino , Adulto Jovem , Artroscopia/métodos , Desbridamento/métodos , Fixação Interna de Fraturas/métodos , Período Pós-Operatório , Amplitude de Movimento Articular , Projetos de Pesquisa , Revisões Sistemáticas como Assunto , Resultado do Tratamento , Ulna/fisiopatologia , Ulna/cirurgia , Fraturas da Ulna/fisiopatologia , Fraturas da Ulna/cirurgia
10.
Curr Osteoporos Rep ; 18(1): 13-22, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-32088857

RESUMO

PURPOSE OF REVIEW: This review updates readers on recent developments in the assessment of cortical bone fragility in vivo. The review explains the clinical need that motivated the development of Cortical Bone Mechanics Technology™ (CBMT) as a scientific instrument, its unique capabilities, and its necessary further development as a medical device. RECENT FINDINGS: Clinical experience with dual-energy X-ray absorptiometry has led to calls for new clinical methods for assessing bone health. CBMT is a noninvasive, dynamic 3-point bending test that makes direct, functional measurements of the mechanical properties of cortical bone in ulnas of living people. Its technical validity in accurate measurements of ulna flexural rigidity and its clinical validity in accurate estimations of quasistatic ulna bending strength have been demonstrated. Because CBMT is a whole bone test, its measurements reflect the influences of bone quantity and bone quality at all hierarchical levels.


Assuntos
Fenômenos Biomecânicos , Osso Cortical/fisiopatologia , Resistência à Flexão , Ulna/fisiopatologia , Absorciometria de Fóton , Humanos , Suporte de Carga
11.
J Shoulder Elbow Surg ; 29(6): 1249-1258, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32044251

RESUMO

BACKGROUND: Radial head instability continues to be a challenge in the management of anterior Monteggia injuries; however, there is a paucity of literature on the factors that contribute to this instability. The aim of this biomechanical investigation was to examine the effects of ulnar angulation and soft tissue insufficiency on radial head stability in anterior Monteggia injuries. METHODS: Six cadaveric arms were mounted in an elbow motion simulator. Radial head translation was measured during simulated active elbow flexion with the forearm supinated. After testing the elbows in the intact state, the ulna was osteotomized and tested at 0°, 10°, 20°, and 30° of extension angulation. To examine the effect of soft tissue insufficiency, the anterior radiocapitellar joint capsule, annular ligament, quadrate ligament, and the proximal and middle interosseous membrane (IOM) were sequentially sectioned. RESULTS: There was a significant increase in anterior radial head translation with greater ulnar extension angulation. Sequential soft tissue sectioning also significantly increased anterior radial head translation. There was no increase in radial head translation with isolated sectioning of the anterior radiocapitellar joint capsule. Additional sectioning of the annular ligament and quadrate ligament slightly increased anterior radial head translation but did not reach statistical significance. Subsequent sectioning of the proximal and middle IOM resulted in significant increases in anterior radial head translation. CONCLUSION: Our study demonstrates that progressive ulnar extension angulation results in an incremental increase in anterior radial head translation in anterior Monteggia injuries. Moreover, increasing magnitudes of soft tissue disruption result in greater anterior radial head instability.


Assuntos
Instabilidade Articular/etiologia , Fratura de Monteggia/complicações , Fratura de Monteggia/fisiopatologia , Rádio (Anatomia)/fisiopatologia , Ulna/fisiopatologia , Idoso , Fenômenos Biomecânicos , Cadáver , Articulação do Cotovelo/fisiopatologia , Epífises , Antebraço , Humanos , Ligamentos Articulares , Pessoa de Meia-Idade , Amplitude de Movimento Articular , Supinação
12.
FASEB J ; 34(2): 2579-2594, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31908007

RESUMO

The skeleton of type 1 diabetes mellitus (T1DM) has deteriorated mechanical integrity and increased fragility, whereas the mechanisms are not fully understood. Load-induced microdamage naturally occurs in bone matrix and can be removed by initiating endogenous targeted bone remodeling. However, the microdamage accumulation in diabetic skeleton and the corresponding bone remodeling mechanisms remain poorly understood. Herein, streptozotocin-induced T1DM rats and age-matched non-diabetic rats were subjected to daily uniaxial ulnar loading for 1, 4, 7, and 10 days, respectively. The SPECT/CT and basic fuchsin staining revealed significant higher-density spatial accumulation of linear and diffuse microdamage in diabetic ulnae than non-diabetic ulnae. Linear microcracks increased within 10-day loading in diabetic bone, whereas peaked at Day 7 in non-diabetic bone. Moreover, diabetic fatigued ulnae had more severe disruptions of osteocyte canaliculi around linear microcracks. Immunostaining results revealed that diabetes impaired targeted remodeling in fatigued bone at every key stage, including increased apoptosis of bystander osteocytes, decreased RANKL secretion, reduced osteoclast recruitment and bone resorption, and impaired osteoblast-mediated bone formation. This study characterizes microdamage accumulation and abnormal remodeling mechanisms in the diabetic skeleton, which advances our etiologic understanding of diabetic bone deterioration and increased fragility from the aspect of microdamage accumulation and bone remodeling.


Assuntos
Remodelação Óssea/fisiologia , Reabsorção Óssea/metabolismo , Diabetes Mellitus/metabolismo , Osteoclastos/metabolismo , Animais , Apoptose/fisiologia , Reabsorção Óssea/fisiopatologia , Masculino , Osteócitos/metabolismo , Ratos Sprague-Dawley , Estresse Mecânico , Ulna/fisiopatologia , Suporte de Carga/fisiologia
13.
Eur J Med Genet ; 63(1): 103615, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30654152

RESUMO

Ulnar-mammary syndrome (UMS) is a rare syndromic limb malformation caused by heterozygous mutations in TBX3. The name highlights the two commonly involved body parts i.e. mammary gland and ulnar ray of the upper limbs, although a more extensive systemic involvement is also known to occur. Here, we report the surprising finding of a patient with a de novo mutation in TBX3 whose clinical presentation is limited to dorsalization of both little fingers and slightly deep 4th web spaces. We review the literature to confirm that this should be considered as a forme fruste phenotype of UMS.


Assuntos
Anormalidades Múltiplas/genética , Doenças Mamárias/genética , Deformidades Congênitas dos Membros/genética , Proteínas com Domínio T/genética , Ulna/anormalidades , Anormalidades Múltiplas/fisiopatologia , Doenças Mamárias/fisiopatologia , Criança , Feminino , Dedos/anormalidades , Dedos/fisiopatologia , Humanos , Deformidades Congênitas dos Membros/fisiopatologia , Mutação/genética , Fenótipo , Ulna/fisiopatologia
14.
Br J Hosp Med (Lond) ; 80(8): 461-465, 2019 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-31437044

RESUMO

Ulnar-sided wrist pain is a complex entity to diagnose clinically and frequently requires imaging to help confirm or determine the diagnosis. This article reviews the imaging and the logical imaging pathway of the common causes of ulnar-sided wrist pain, and illustrates various pathologies. It also discusses appropriate imaging modalities for various conditions. The causes of ulnar-sided wrist pain are stratified according to the affected anatomical structures, such as bony, soft tissue or neurovascular aetiologies. This review provides a handy imaging framework for non-radiologist clinicians of the common conditions producing ulnar-sided wrist pain. A linked article (10.12968/hmed.2019.80.8.456) detailing the diagnosis of ulnar-sided wrist pain is included in this issue.


Assuntos
Artralgia/diagnóstico por imagem , Diagnóstico por Imagem/métodos , Ulna/diagnóstico por imagem , Articulação do Punho/diagnóstico por imagem , Artralgia/etiologia , Artralgia/fisiopatologia , Feminino , Humanos , Masculino , Medição da Dor , Sensibilidade e Especificidade , Traumatismos dos Tendões/complicações , Traumatismos dos Tendões/diagnóstico por imagem , Ulna/fisiopatologia , Traumatismos do Punho/complicações , Traumatismos do Punho/diagnóstico por imagem , Articulação do Punho/fisiopatologia
15.
J Hand Surg Am ; 44(8): 669-679, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31171375

RESUMO

PURPOSE: To evaluate the effect of ulnar shortening on distal forearm loading following simulated dynamic motion. METHODS: Ulnar shortening was simulated using a custom-built adjustable implant to simulate up to 4 mm of ulnar shortening (-4 mm) in 9 cadaveric extremities. Load cells were placed in the distal ulna and radius to quantify axial loading. Using a wrist and forearm motion simulator, absolute and percentage loads were measured during dynamic flexion, ulnar deviation (UD), flexion dart throw (DT), and pronation. RESULTS: There was a significant decrease in absolute and percentage distal ulnar loads at each interval of ulnar shortening during flexion, UD, DT, and pronation. The distal ulna bore no compressive loads, and in fact, tensile loads were measured in the ulna at 2 mm of ulnar shortening during DT and pronation, at 3 mm during flexion, and at 4 mm during UD. CONCLUSIONS: A progressive decrease in distal ulnar loads with generation of tensile loads was observed with sequential ulnar shortening. CLINICAL RELEVANCE: Ulnar shortening greater than 2 mm can result in tensile loading in the distal ulna. When managing ulnar impaction syndrome, excessive shortening may not be required to provide relief of symptoms.


Assuntos
Articulações do Carpo/fisiopatologia , Ulna/fisiopatologia , Ulna/cirurgia , Idoso , Idoso de 80 Anos ou mais , Fenômenos Biomecânicos , Cadáver , Articulações do Carpo/cirurgia , Antebraço/fisiopatologia , Humanos , Técnicas In Vitro , Pessoa de Meia-Idade , Procedimentos Ortopédicos , Osteotomia , Próteses e Implantes , Amplitude de Movimento Articular , Estresse Mecânico , Síndrome , Suporte de Carga , Articulação do Punho/fisiopatologia , Articulação do Punho/cirurgia
16.
J Hand Surg Am ; 44(7): 556-563.e5, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31126814

RESUMO

PURPOSE: To evaluate the effect of radial length change on distal forearm loading during simulated dynamic wrist motion. METHODS: A custom-built adjustable radial implant was used to simulate up to 4 mm of distal radius shortening (-4 mm) and 3 mm of lengthening (+3 mm). Load cells were placed in the distal radius and ulna in cadavers to measure their respective axial loads. The specimens were mounted on a wrist motion simulator that produced active wrist motion via tendon actuation. To simulate radial lengthening osteotomy following radial shortening from malunion, the radius was sequentially lengthened by 1-mm intervals from -4 mm to +3 mm. Radial and ulnar loads were measured during simulated wrist flexion, ulnar deviation (UD), and flexion dart throw (DT) at each interval of radial lengthening up to +3 mm. RESULTS: During wrist flexion and UD, for each millimeter of radial lengthening from -4 mm to the native length, there was a significant increase in distal radial loads. No significant change in radial load was observed beyond the native length during flexion and UD. There was no change in distal radial loads during DT for each interval of radial lengthening from -4 mm to +3 mm. A sequential decrease in ulnar loads was observed as the radius was lengthened from -4 mm to +3 mm for all wrist motions evaluated. CONCLUSIONS: Radial lengthening beyond the native length was not detrimental to radial loading and further reduced distal ulnar loading; achieving at least native ulnar variance seems to be appropriate to restore normal biomechanical loading based on this in vitro study. CLINICAL RELEVANCE: Lengthening of the radius beyond native variance in the setting of ulnar impaction syndrome, distal radius malunion, or distal radioulnar instability may not result in excessive loading of the distal radius and further reduces loading on the distal ulna. Surgeons should obtain contralateral wrist x-rays to serve as a template when performing distal radius osteotomies.


Assuntos
Alongamento Ósseo , Osteotomia , Rádio (Anatomia)/cirurgia , Amplitude de Movimento Articular/fisiologia , Suporte de Carga/fisiologia , Articulação do Punho/fisiopatologia , Idoso , Idoso de 80 Anos ou mais , Cadáver , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Anatômicos , Ulna/fisiopatologia
17.
J Hand Surg Eur Vol ; 44(5): 488-495, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30799668

RESUMO

We retrospectively reviewed 26 patients diagnosed with idiopathic ulnar impaction syndrome and measured the slopes of the sigmoid notch and ulnar head at their centre using their preoperative three-dimensional computed tomography. We found that the slope of the sigmoid notch and that of the ulnar head were not parallel to each other. There was a significant linear relation between the slope of the ulnar head and the changes in the closest joint space of the distal radioulnar joint at the centre of the sigmoid notch after ulnar shortening. We conclude that the slope of the ulnar head is more strongly correlated with changes in the closest joint space in the distal radioulnar joint than that of the sigmoid notch. Our findings suggest that slope of the ulnar head might be as important a predisposing factor as that of the sigmoid notch for the progression of distal radioulnar joint arthritis after ulnar-shortening osteotomy. We should consider the slopes of both the sigmoid notch and ulnar head before the osteotomy. Level of evidence: IV.


Assuntos
Imageamento Tridimensional , Ulna/diagnóstico por imagem , Articulação do Punho/diagnóstico por imagem , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Osteotomia , Reprodutibilidade dos Testes , Estudos Retrospectivos , Síndrome , Tomografia Computadorizada por Raios X , Ulna/fisiopatologia , Ulna/cirurgia , Adulto Jovem
18.
Hand (N Y) ; 14(4): 540-546, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-29463126

RESUMO

Background: Acute management of fractures of the distal ulna that are associated with fractures of the distal radius remains difficult, particularly in the elderly. Methods: In this study, we investigated whether internal fixation of the distal ulna is associated with a higher rate of complications than resection of the distal ulna in patients older than 70 years. Twenty-four consecutive patients were included in this study, 12 of whom had undergone open reduction and internal fixation (ORIF) of the distal ulna, and 12 who had undergone distal ulna resection. Patients were retrospectively assessed for range of motion, grip strength, pain, and radiographic appearance. The functional outcome was evaluated by the Mayo Wrist Score. Complications were classified according to the Classification of Surgical Complications. Results: There were no differences in patient demographics between the 2 groups, except patient age. Clinical evaluation showed no difference at follow-up; however, there were significantly more complications associated with ORIF compared with resection. Conclusions: The results from our study show that women older than 70 years with fracture of the distal radius and distal ulna have a higher rate of complications if ORIF of the distal ulna is performed. Patients should be warned, by surgeons, of this in cases where ORIF of the distal ulna is suggested.


Assuntos
Fixação Interna de Fraturas/efeitos adversos , Redução Aberta/efeitos adversos , Fraturas do Rádio/cirurgia , Fraturas da Ulna/cirurgia , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Fixação Interna de Fraturas/métodos , Humanos , Masculino , Redução Aberta/métodos , Medição da Dor/estatística & dados numéricos , Complicações Pós-Operatórias/epidemiologia , Radiografia/métodos , Fraturas do Rádio/diagnóstico por imagem , Fraturas do Rádio/epidemiologia , Amplitude de Movimento Articular/fisiologia , Estudos Retrospectivos , Ulna/fisiopatologia , Ulna/cirurgia , Fraturas da Ulna/diagnóstico por imagem , Fraturas da Ulna/epidemiologia
19.
J Hand Surg Eur Vol ; 44(6): 589-593, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30380991

RESUMO

Forty-four patients who had been diagnosed with ulnar impaction syndrome and who were scheduled to undergo ulnar shortening osteotomy were randomized into two groups, one treated by ulnar shortening osteotomy alone and the other treated by ulnar shortening osteotomy combined with arthroscopic debridement. The response to treatment, including the pain numeric rating scale in an ulnar provocation test and the Disability of the Arm, Shoulder and Hand score was assessed at 3 and 12 months after surgery. The mean pain and disability scores showed significant clinical improvement at the 12-month follow-up in both groups. The pain scores at 3 months of follow-up were significantly better in the ulnar shortening osteotomy with arthroscopic debridement group. However, no significant differences were observed between the two groups in the disability scores at 3 and 12 months, or in the pain scores at 12-month follow-up. We conclude that similar improvements in symptom severity and hand function occurred in the long term in patients both with and without concomitant arthroscopic debridement. This information regarding concomitant arthroscopy could be used in the informed consent discussion with patients scheduled for ulnar shortening osteotomy. Level of evidence: II.


Assuntos
Artroscopia , Desbridamento , Osteotomia , Ulna/cirurgia , Articulação do Punho/fisiopatologia , Adulto , Avaliação da Deficiência , Feminino , Força da Mão/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Estudos Prospectivos , Ulna/fisiopatologia
20.
J Hand Surg Asian Pac Vol ; 23(3): 313-319, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30282532

RESUMO

BACKGROUND: This purpose of the study was to conduct a systematic review of available literature regarding the association between ulnar variance and outcomes after repair of peripheral traumatic tears of the triangular fibrocartilage complex (TFCC). METHODS: A systematic literature search of the medical literature about peripheral tears of the TFCC was performed. We selected seven studies comparing clinical outcome and ulnar variance in patients with peripheral TFCC tears. We evaluated quality of the articles using both the Structured Effectiveness Quality Evaluation Scale (SEQES) and Sackett's Level of Evidence (LOE). The outcomes were objective or self-assessment scoring systems for the function of the hand, wrist, or upper extremity. RESULTS: Seven articles were evaluated. The SEQES scores varied from 19 to 28, with a mean of 23. Five studies reported no association between ulnar variance and clinical outcome, and 2 studies reported an association. The studies reporting no association either excluded or did not mention the cases of unstable distal radioulnar joint (DRUJ). CONCLUSIONS: This systematic review did not demonstrate strong evidence regarding the association between ulnar variance and outcomes after TFCC repair. As most of the studies did not distinguish between capsular and foveal tears which can affect DRUJ stability, further studies looking at this point are necessary to determine whether ulnar shortening osteotomy has an added value for better outcomes after TFCC repair.


Assuntos
Artroscopia/métodos , Osteotomia/métodos , Fibrocartilagem Triangular/cirurgia , Traumatismos do Punho/cirurgia , Humanos , Fibrocartilagem Triangular/fisiopatologia , Ulna/fisiopatologia , Traumatismos do Punho/fisiopatologia
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