RESUMO
The aim of the study was to investigate the characteristics of ocular toxocariasis (OT) presenting with intermediate uveitis in the Korean population.We studied intermediate uveitis patients using ocular and systemic evaluations and a Toxocara IgG serology test.Of 50 intermediate uveitis patients, 19 were seropositive for Toxocara IgG. Of the 19 OT patients, 4 presented with recurrence within 6 months and were significantly younger than nonrecurrence patients (Pâ=â0.009). Thirteen patients had a history of eating raw cow liver.There were 14 males and 5 females in the OT group, and 11 males and 20 females in the non-OT group (Pâ=â0.009). There was bilateral involvement in 7 out of 19 patients in the OT group, and 20 out of 31 patients in non-OT group (Pâ=â0.033).Intermediate uveitis patients in OT were predominately male and had more unilateral presentation than non-OT patients.
Assuntos
Toxocaríase/epidemiologia , Uveíte Intermediária/epidemiologia , Uveíte Intermediária/parasitologia , Adulto , Idoso , Animais , Bovinos , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Fígado/parasitologia , Masculino , Pessoa de Meia-Idade , Alimentos Crus/parasitologia , República da Coreia/epidemiologia , Estudos Soroepidemiológicos , Toxocaríase/etiologiaAssuntos
Oftalmopatias/diagnóstico , Giardíase/diagnóstico , Vasculite Retiniana/diagnóstico , Uveíte Intermediária/diagnóstico , Transtornos da Visão/diagnóstico , Corpo Vítreo/patologia , Adulto , Antiprotozoários/uso terapêutico , Oftalmopatias/parasitologia , Feminino , Angiofluoresceinografia , Giardia/isolamento & purificação , Giardíase/tratamento farmacológico , Giardíase/parasitologia , Humanos , Metronidazol/uso terapêutico , Vasculite Retiniana/parasitologia , Tinidazol/uso terapêutico , Tomografia de Coerência Óptica , Uveíte Intermediária/parasitologia , Transtornos da Visão/parasitologiaRESUMO
We report the use of DNA chip technology in the identification of Toxoplasma gondii as the etiological agent in two patients with recurrent intermediate uveitis (IU). Both patients had recurrent episodes of vitritis (with no focal retinochoroidal lesion) over varying time intervals and were diagnosed to have IU. The tuberculin test was negative in both. Blood counts, erythrocyte sedimentation rate, and serum angiotensin convertase enzyme levels were normal. In both cases, the vitreous fluid tested positive for the T. gondii DNA sequence by using a uveitis DNA chip (XCyton Pvt. Ltd., Bangalore, India). It contained complimentary sequences to "signature genes" of T. gondii, Mycobacterium tuberculosis, M. chelonae, and M. fortuitum. The enzyme-linked immunosorbent assay (ELISA) detected elevated serum antitoxoplasma IgG levels in both. They responded to the antitoxoplasma therapy with oral co-trimoxazole (and additional intravitreal clindamycin in patient 1), with no recurrence during follow-ups of 6 and 8 months, respectively.
