RESUMO
The immunoenzyme detection systems for the measurement of the alpha-2 globulin of the brain (alpha 2M) and glial fibrillary acidic antigens (GFAP) were developed. These systems were used for the study of the penetration through hemato-encephalic barrier in rats subjected to gamma radiation. This method is recommended for the indirect evaluation of the hemato-encephalic barrier functional disorders.
Assuntos
Barreira Hematoencefálica/efeitos da radiação , Encéfalo/efeitos da radiação , Permeabilidade da Membrana Celular/efeitos da radiação , Epitopos/análise , Lesões Experimentais por Radiação/imunologia , Doença Aguda , alfa-Globulinas/análise , alfa-Globulinas/imunologia , alfa-Globulinas/efeitos da radiação , Animais , Anticorpos/análise , Especificidade de Anticorpos , Encéfalo/imunologia , Epitopos/imunologia , Epitopos/efeitos da radiação , Feminino , Raios gama , Proteína Glial Fibrilar Ácida/análise , Proteína Glial Fibrilar Ácida/imunologia , Proteína Glial Fibrilar Ácida/efeitos da radiação , Imunodifusão , Técnicas Imunoenzimáticas , Masculino , RatosRESUMO
The concentration of alpha- and beta-globulins in the serum can be increased by exposure of the globulin-producing tissue of the liver to ultrasound. The ultrasound intensities producing this effect are harmless according to our present knowledge. Especially the concentration of the globulin carcinoembryonic antigen in the serum can be increased significantly by exposure of CEA-producing carcinomas to ultrasound. There is to investigate the possibility of the early detection of CEA-producing tumors using a provocation test by way of increasing still normal spontaneous CEA-concentrations in the serum by insonation of body regions in question to significant pathologic serum concentrations.