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1.
Oncology (Williston Park) ; 38(1): 15-19, 2024 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-38300531

RESUMO

BACKGROUND: The study of health-related quality of life in survivors of gynecologic cancers is becoming increasingly important as 1.5 million survivors of gynecologic cancer in the United States and more are expected due to advances in diagnosis and treatment. This project investigated the perceived needs and lived experiences of survivors of gynecological cancer to help design supportive activities to be implemented in clinical practice. METHODS: Patients were recruited in hospitals or through social media and responded to an online survey that was addressed to patients in Italy, specifically in Sicily, Puglia, and Campania. Patients with ovarian, endometrium, or cervix cancer were recruited among women attending Cannizzaro Hospital and Alleanza Contro il Tumore Ovarico (Alliance Against Ovarian Cancer) members. RESULTS: Body image perception was changed in 82.3% of respondents, whereas familial relationships were described as changed by 27.5% of women. In 69.6% of patients, sexual habits were hindered by changes in the body, depression, pain, and awkwardness. Physicians informed patients about sexuality changes related to cancer extensively in 16.7% of cases and briefly in 19.6% of cases. The advice of a clinical sexologist was considered potentially helpful by 31.4% of patients and not potentially helpful by 47.1%, whereas 21.6% of patients had no opinion. CONCLUSIONS: Although sexual habits are often changed by cancer, women surviving gynecological cancer rarely seek medical advice in this area. Physicians should be trained to inform patients and to promote referrals to sexologists.


Assuntos
Neoplasias Ovarianas , Neoplasias do Colo do Útero , Feminino , Humanos , Acontecimentos que Mudam a Vida , Qualidade de Vida , Itália
2.
Sci Rep ; 14(1): 3896, 2024 02 16.
Artigo em Inglês | MEDLINE | ID: mdl-38365930

RESUMO

Mechanisms through which most known Alzheimer's disease (AD) loci operate to increase AD risk remain unclear. Although Apolipoprotein E (APOE) is known to regulate lipid homeostasis, the effects of broader AD genetic liability on non-lipid metabolites remain unknown, and the earliest ages at which metabolic perturbations occur and how these change over time are yet to be elucidated. We examined the effects of AD genetic liability on the plasma metabolome across the life course. Using a reverse Mendelian randomization framework in two population-based cohorts [Avon Longitudinal Study of Parents and Children (ALSPAC, n = 5648) and UK Biobank (n ≤ 118,466)], we estimated the effects of genetic liability to AD on 229 plasma metabolites, at seven different life stages, spanning 8 to 73 years. We also compared the specific effects of APOE ε4 and APOE ε2 carriage on metabolites. In ALSPAC, AD genetic liability demonstrated the strongest positive associations with cholesterol-related traits, with similar magnitudes of association observed across all age groups including in childhood. In UK Biobank, the effect of AD liability on several lipid traits decreased with age. Fatty acid metabolites demonstrated positive associations with AD liability in both cohorts, though with smaller magnitudes than lipid traits. Sensitivity analyses indicated that observed effects are largely driven by the strongest AD instrument, APOE, with many contrasting effects observed on lipids and fatty acids for both ε4 and ε2 carriage. Our findings indicate pronounced effects of the ε4 and ε2 genetic variants on both pro- and anti-atherogenic lipid traits and sphingomyelins, which begin in childhood and either persist into later life or appear to change dynamically.


Assuntos
Doença de Alzheimer , Criança , Humanos , Doença de Alzheimer/genética , Doença de Alzheimer/metabolismo , Genótipo , Estudos Longitudinais , Acontecimentos que Mudam a Vida , Apolipoproteínas E/genética , Apolipoproteína E4/genética
4.
Artigo em Inglês | MEDLINE | ID: mdl-38397678

RESUMO

This article reports on participants' experiences with long COVID-19 (LC) (symptoms, impact, healthcare use, and perceived needs) and satisfaction with a patient-oriented knowledge-sharing session organized by a multidisciplinary team of healthcare professionals, researchers, and a patient partner. Twenty-six participants completed a pre-session survey. On average, they were 21 months post-COVID-19 infection (SD 10.9); 81% of them were female, and 84% were 40+ years old. The main symptoms reported included fatigue (96%), cognitive problems (92%), and general pain or discomfort (40%). More than half of the participants reported that LC has had a significant impact on their health-related quality of life. Eighty-one percent of the participants reported seeking medical help for their LC symptoms and found the services provided by physical therapists, primary care providers, and acupuncturists to be helpful in managing their condition. Participants would like to have access to healthcare providers and clinics specializing in LC. They liked the session and found the information presented useful. This information helps to better understand the experiences of people living with LC and how to support their recovery.


Assuntos
COVID-19 , Síndrome Pós-COVID-19 Aguda , Humanos , Feminino , Adulto , Masculino , Qualidade de Vida , Acontecimentos que Mudam a Vida , COVID-19/epidemiologia , Atenção à Saúde
5.
Front Endocrinol (Lausanne) ; 15: 1285872, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38390197

RESUMO

Aims: Previous Mendelian randomization (MR) of obesity and diabetic nephropathy (DN) risk used small sample sizes or focused on a single adiposity metric. We explored the independent causal connection between obesity-related factors and DN risk using the most extensive GWAS summary data available, considering the distribution of adiposity across childhood and adulthood. Methods: To evaluate the overall effect of each obesity-related exposure on DN (Ncase = 3,676, Ncontrol = 283,456), a two-sample univariate MR (UVMR) analysis was performed. The independent causal influence of each obesity-related feature on DN was estimated using multivariable MR (MVMR) when accounting for confounding variables. It was also used to examine the independent effects of adult and pediatric obesity, adjusting for their interrelationships. We used data from genome-wide association studies, including overall general (body mass index, BMI) and abdominal obesity (waist-to-hip ratio with and without adjustment for BMI, i.e., WHR and WHRadjBMI), along with childhood obesity (childhood BMI). Results: UVMR revealed a significant association between adult BMI (OR=1.24, 95%CI=1.03-1.49, P=2.06×10-2) and pediatric BMI (OR=1.97, 95%CI=1.59-2.45, P=8.55×10-10) with DN risk. At the same time, adult WHR showed a marginally significant increase in DN (OR =1.27, 95%CI = 1.01-1.60, P=3.80×10-2). However, the outcomes were adverse when the influence of BMI was taken out of the WHR (WHRadjBMI). After adjusting for childhood BMI, the causal effects of adult BMI and adult abdominal obesity (WHR) on DN were significantly attenuated and became nonsignificant in MVMR models. In contrast, childhood BMI had a constant and robust independent effect on DN risk(adjusted for adult BMI: IVW, OR=1.90, 95% CI=1.60-2.25, P=2.03×10-13; LASSO, OR=1.91, 95% CI=1.65-2.21, P=3.80×10-18; adjusted for adult WHR: IVW, OR=1.80, 95% CI=1.40-2.31, P=4.20×10-6; LASSO, OR=1.90, 95% CI=1.56-2.32, P=2.76×10-10). Interpretation: Our comprehensive analysis illustrated the hazard effect of obesity-related exposures for DN. In addition, we showed that childhood obesity plays a separate function in influencing the risk of DN and that the adverse effects of adult obesity (adult BMI and adult WHR) can be substantially attributed to it. Thus, several obesity-related traits deserve more attention and may become a new target for the prevention and treatment of DN and warrant further clinical investigation, especially in childhood obesity.


Assuntos
Diabetes Mellitus , Nefropatias Diabéticas , Obesidade Pediátrica , Adulto , Criança , Humanos , Adiposidade/genética , Obesidade Pediátrica/complicações , Obesidade Pediátrica/epidemiologia , Obesidade Pediátrica/genética , Obesidade Abdominal , Nefropatias Diabéticas/etiologia , Nefropatias Diabéticas/genética , Estudo de Associação Genômica Ampla , Acontecimentos que Mudam a Vida , Análise da Randomização Mendeliana
6.
J Child Adolesc Psychiatr Nurs ; 37(1): e12452, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38368550

RESUMO

TOPIC: Early-life experiences, the transmission of health and disease within families, and the influence of cumulative risks as well as protective factors throughout life shape the trajectory of health, including mental health. Long-term health trajectories established early in life are influenced by biologic, social, and environmental factors. Negative trajectories may be more salient if exposures to adversity occur during critical developmental periods. PURPOSE: The purpose of this brief is to (a) review pediatric health disparities related to depression and the intergenerational transmission of pediatric depression using a Life Course Health Development (LCHD) model and (b) provide recommendations for pediatric mental health research. SOURCES: Peer-reviewed papers available for PubMed, CINAL, and Medline. Other sources include published books, papers, and gray materials. CONCLUSIONS: The LCHD model is a perspective to guide and foster new scientific inquiry about the development of mental health outcomes over the life course. The model enables synthesis of mental health, nursing, and public health, linking mental health prevention, risk reduction, and treatment in children.


Assuntos
Acontecimentos que Mudam a Vida , Saúde Mental , Humanos , Criança , Iniquidades em Saúde
7.
Int J Public Health ; 69: 1606278, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38384748

RESUMO

Objective: This study examined how individuals' ideal weight and weight discrepancy (between ideal and actual weight) changed over the life course and across cohorts. Methods: The study used population-representative longitudinal data collected in the Netherlands (N = 61,431 observations between 2007 and 2018 among N = 13,409 individuals aged 16 to 80 and born 1927-2000). Results: Ideal weight increased linearly with age. Weight discrepancy showed a bell-shaped age pattern. Approximately half of the age-related increase in ideal weight was associated with concurrent increases in actual weight. Ideal weight and weight discrepancy increased slightly across cohorts. The cohort-related increase in ideal weight vanished after adjusting for change in actual weight. Analyses of population heterogeneity showed similar patterns of change in both outcomes across groups, although levels differed by gender, education, and migration status even after adjusting for differences in actual weight between these groups. Conclusion: These results show that ideal weight and weight discrepancy in the Netherlands change substantially with age and modestly across cohorts. Potential explanations include changes in physical appearance and in the importance of physical appearance.


Assuntos
Acontecimentos que Mudam a Vida , Humanos , Países Baixos , Escolaridade
8.
PLoS One ; 19(2): e0298546, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38408059

RESUMO

Depressive disorders are leading contributors to morbidity in low- and middle-income countries and are particularly prevalent among people with non-communicable diseases (NCD). Stressful life events (SLEs) are risk factors for, and can help identify those at risk of, severe depressive illness requiring more aggressive treatment. Yet, research on the impact of SLEs on the trajectory of depressive symptoms among NCD patients indicated for depression treatment is lacking, especially in low resource settings. This study aims to estimate the longitudinal association of SLEs at baseline with depression remission achievement at three, six, and 12 months among adults with either hypertension or diabetes and comorbid depression identified as being eligible for depression treatment. Participants were recruited from 10 NCD clinics in Malawi from May 2019-December 2021. SLEs were measured by the Life Events Survey and depression remission was defined as achieving a Patient Health Questionaire-9 (PHQ-9) score <5 at follow-up. The study population (n = 737) consisted predominately of females aged 50 or higher with primary education and current employment. At baseline, participants reported a mean of 3.5 SLEs in the prior three months with 90% reporting ≥1 SLE. After adjustment, each additional SLE was associated with a lower probability of achieving depression remission at three months (cumulative incidence ratio (CIR) 0.94; 95% confidence interval: 0.90, 0.98, p = 0.002), six months (0.95; 0.92, 0.98, p = 0.002) and 12 months (0.96; 0.94, 0.99, p = 0.011). Re-expressed per 3-unit change, the probability of achieving depression remission at three, six, and 12 months was 0.82, 0.86, and 0.89 times lower per 3 SLEs (the median number of SLEs). Among NCD patients identified as eligible for depression treatment, recent SLEs at baseline were associated with lower probability of achieving depression remission at three, six, and 12 months. Findings suggest that interventions addressing SLEs during integrated NCD and depression care interventions (e.g., teaching and practicing SLE coping strategies) may improve success of depression treatment among adult patient populations in low-resource settings and may help identify those at risk of severe and treatment resistant depression.


Assuntos
Diabetes Mellitus , Hipertensão , Doenças não Transmissíveis , Adulto , Feminino , Humanos , Depressão/complicações , Depressão/epidemiologia , Malaui/epidemiologia , Acontecimentos que Mudam a Vida , Fatores de Risco
9.
Washington, D.C.; OPAS; 2024-02-01.
Não convencional em Português | PAHO-IRIS | ID: phr-59246

RESUMO

As Américas passam por profundas mudanças demográficas, e há mais pessoas com 65 anos ou mais do que crianças com menos de 5 anos. Portanto, é crucial reconhecer que os programas nacionais de imunização precisam ser reconfigurados para garantir uma proteção abrangente para os indivíduos ao longo da vida. Ao adotarem a abordagem de curso de vida para a imunização, os programas de vacinação podem ser adaptados para diminuir as lacunas de imunidade em diferentes fases da vida. A abordagem de curso de vida prevê o estabelecimento de diversas estratégias para reduzir as oportunidades perdidas de vacinação de acordo com a faixa etária. Este documento técnico explica os principais conceitos da abordagem de curso de vida, com foco na imunização por vacinação, bem como os mecanismos biológicos subjacentes que requerem a aplicação de diferentes vacinas em diferentes fases da vida, conforme as mudanças no sistema imunológico e a situação epidemiológica da comunidade. São fornecidos exemplos de diferentes vacinas. Por último, o documento oferece várias considerações para a implementação da abordagem de curso de vida nos programas nacionais de imunização. Este documento faz parte dos esforços da Organização Pan-Americana da Saúde para introduzir os conceitos de imunização ao longo da vida nos países e territórios das Américas e assegurar que todas as pessoas colham todos os benefícios que as vacinas podem proporcionar. Ao reconhecer o impacto da vacinação ao longo da vida e implementar a abordagem de curso de vida, os países podem minimizar o impacto das doenças, aumentar a resiliência do organismo durante toda a vida e reduzir as taxas gerais de mortalidade. Os programas de imunização, antes centrados principalmente na primeira infância, podem evoluir para intervenções adaptáveis de saúde pública, salvaguardando a saúde e o bem-estar de indivíduos de todas as idades.


Assuntos
Imunidade , Imunoterapia , Doenças Transmissíveis , Doenças Transmissíveis , Imunização , Programas de Imunização , Atenção Primária à Saúde , Acontecimentos que Mudam a Vida
12.
Artigo em Inglês | MEDLINE | ID: mdl-38276813

RESUMO

Family caregivers provide care to people with disabilities, as well as ill and older adults, often with little to no outside assistance from the formal long-term care system. They are the backbone of long-term care, and it is a misconception that the majority of people institutionalize disabled people and older adults in the United States. Youth caregiving is under-examined in the field of public health and is in need of theoretical and practical attention. Building upon the work of Talley and Crews and Bronfenbrenner, we aim to broaden the scope of the discussion around caregiving through the application of the social-ecological model (SEM) to inform research and practice. This paper picks up where they left off, digging deeper into the ecological model to reimagine research, policy, and practices related to youth and young adult caregivers that are rooted in this framework. This application highlights care as embedded in social relations while allowing for an exploration of the ways structural barriers impact the caring unit. Looking holistically at the unit, rather than individuals as service users, provides an opportunity for understanding the interconnectedness of those giving and receiving care. It does so by rendering visible the interdependence of the caring unit, and the myriad structures, which bear down on care at the individual and household levels. This approach runs counter to dominant thinking, which focuses exclusively on the individuals involved in caregiving relationships, rather than considering them as interdependent units of care. This paper provides an analytic contribution, utilizing a narrative composite vignette based on literature and previous research.


Assuntos
Acontecimentos que Mudam a Vida , Meio Social , Adulto Jovem , Adolescente , Humanos , Estados Unidos , Idoso , Modelos Teóricos , Assistência de Longa Duração , Cuidadores , Família
13.
J Affect Disord ; 349: 145-157, 2024 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-38190863

RESUMO

BACKGROUND: Major life events can lead to depression in adulthood. However, as predicted by several depression theories, not only the mere occurrence of major life events but also the way people perceive them determines the onset of a depression. METHODS: Based on a systematic literature search, we identified 276 studies (Ntotal = 89,600) that examined the relationship between the perception of major life events and depression. We provide an overview of how this relationship has been examined. Furthermore, we meta-analytically integrated 420 effect sizes (172 studies) on the association between the perception of major life events and depression. RESULTS: Most studies relied on college student samples, were cross-sectional, and were conducted in the United States. A more negative perception of events was significantly associated with higher levels of depressive symptoms (r = 0.28). This association was robust across several design and sample characteristics. Furthermore, the perception of major life events and depression were also longitudinally associated with each other (event perception predicting later depressive symptoms: r = 0.26; depressive symptoms predicting later event perception: r = 0.17). LIMITATIONS: Longitudinal research on the relationship between depression and the perception of major life events was relatively rare impairing definite conclusions on whether the perception of life events can predict changes in depressive symptoms over time. CONCLUSION: The perception of major life events is related to depression. However, further longitudinal research considering a range of different perceived event characteristics and using non-Western heterogeneous samples is needed to better understand their relationship.


Assuntos
Depressão , Estudantes , Humanos , Depressão/diagnóstico , Percepção , Acontecimentos que Mudam a Vida
14.
J Affect Disord ; 349: 569-576, 2024 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-38199410

RESUMO

BACKGROUND: Stressful life events (SLEs) constitute key risk factors for depression. However, previous studies examining associations between SLEs and depression have been limited by focusing on single events, combining events into broad categories, and/or ignoring interrelationships between events in statistical analyses. Network analysis comprises a set of statistical methods well-suited for assessing relationships between multiple variables and can help surpass several limitations of previous studies. METHODS: We applied network analysis using mixed graphical models combining two large-scale population-based samples and >34,600 randomly sampled adults to investigate the associations between SLEs and current depressive symptoms in the general population. RESULTS: Numerous SLEs were uniquely associated with specific symptoms. Strong pairwise links were observed between SLEs during the past year and individual symptoms, e.g., between having experienced illness or injury and sleeping problems, having been degraded or humiliated and feeling blue, and between financial problems and hopelessness and being worried and anxious. Several SLEs, such as financial problems, sexual abuse, and having been degraded or humiliated, were associated with symptoms across more than one timepoint. More recent SLEs were generally more strongly associated with depressive symptoms. Several life events were strongly interrelated, such as multiple forms of abuse, and financial problems, unemployment, divorce, and serious illness or injury. LIMITATIONS: Limitations include a retrospective SLE measure, cross-sectional data, a brief self-report measure of depressive symptoms, and possible attrition bias in the sample. CONCLUSIONS: Our findings may have implications for public health efforts seeking to improve population mental health.


Assuntos
Depressão , Acontecimentos que Mudam a Vida , Humanos , Adulto , Depressão/epidemiologia , Depressão/psicologia , Estudos Retrospectivos , Estudos Transversais , Fatores de Risco
15.
BMJ Open ; 14(1): e076711, 2024 01 18.
Artigo em Inglês | MEDLINE | ID: mdl-38238056

RESUMO

PURPOSE: Using Wales's national dataset for maternity and births as a core dataset, we have linked related datasets to create a more complete and comprehensive entire country birth cohort. Data of anonymised identified persons are linked on the individual level to data from health, social care and education data within the Secure Anonymised Information Linkage (SAIL) Databank. Each individual is assigned an encrypted Anonymised Linking Field; this field is used to link anonymised individuals across datasets. We present the descriptive data available in the core dataset, and the future expansion plans for the database beyond its initial development stage. PARTICIPANTS: Descriptive information from 2011 to 2023 has been gathered from the National Community Child Health Database (NCCHD) in SAIL. This comprehensive dataset comprises over 400 000 child electronic records. Additionally, survey responses about health and well-being from a cross-section of the population including 2500 parents and 30 000 primary school children have been collected for enriched personal responses and linkage to the data spine. FINDINGS TO DATE: The electronic cohort comprises all children born in Wales since 2011, with follow-up conducted until they finish primary school at age 11. The child cohort is 51%: 49% female: male, and 7.8% are from ethnic minority backgrounds. When considering age distribution, 26.8% of children are under the age of 5, while 63.2% fall within the age range of 5-11. FUTURE PLANS: Born in Wales will expand by 30 000 new births annually in Wales (in NCCHD), while including follow-up data of children and parents already in the database. Supplementary datasets complement the existing linkage, including primary care, hospital data, educational attainment and social care. Future research includes exploring the long-term implications of COVID-19 on child health and development, and examining the impact of parental work environment on child health and development.


Assuntos
Coorte de Nascimento , Etnicidade , Gravidez , Criança , Humanos , Masculino , Feminino , País de Gales/epidemiologia , Acontecimentos que Mudam a Vida , Grupos Minoritários , Armazenamento e Recuperação da Informação , Pais
16.
Nat Med ; 30(1): 1, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38242978
17.
Int J Epidemiol ; 53(1)2024 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-38205821

RESUMO

BACKGROUND: Life course epidemiology examines associations between repeated measures of risk and health outcomes across different phases of life. Empirical research, however, is often based on discrete-time models that assume that sporadic measurement occasions fully capture underlying long-term continuous processes of risk. METHODS: We propose (i) the functional relevant life course model (fRLM), which treats repeated, discrete measures of risk as unobserved continuous processes, and (ii) a testing procedure to assign probabilities that the data correspond to conceptual models of life course epidemiology (critical period, sensitive period and accumulation models). The performance of the fRLM is evaluated with simulations, and the approach is illustrated with empirical applications relating body mass index (BMI) to mRNA-seq signatures of chronic kidney disease, inflammation and breast cancer. RESULTS: Simulations reveal that fRLM identifies the correct life course model with three to five repeated assessments of risk and 400 subjects. The empirical examples reveal that chronic kidney disease reflects a critical period process and inflammation and breast cancer likely reflect sensitive period mechanisms. CONCLUSIONS: The proposed fRLM treats repeated measures of risk as continuous processes and, under realistic data scenarios, the method provides accurate probabilities that the data correspond to commonly studied models of life course epidemiology. fRLM is implemented with publicly-available software.


Assuntos
Neoplasias da Mama , Insuficiência Renal Crônica , Humanos , Feminino , Acontecimentos que Mudam a Vida , Teorema de Bayes , Inflamação , Insuficiência Renal Crônica/epidemiologia , Neoplasias da Mama/epidemiologia
18.
J Trauma Stress ; 37(1): 16-18, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38229413

RESUMO

In response to Marx et al.'s (2023) article, "The PTSD Criterion A debate: A brief history, current status, and recommendations for moving forward," this commentary offers agreement with the recommendation to conduct population-based studies to inform future Criterion A changes. However, to fully address the debate as to whether Criterion A should be expanded, limited, eliminated, or remain unchanged, it is critical that future population-based research focus on cultural inclusivity and the addition of potentially traumatic experiences that are collective and/or cumulative versus individual and discrete. To further understand the etiology of mental health distress and disorder and the role of adverse life experiences, it is also recommended that adverse event specifiers be added to disorders not currently considered to be event-related. The ability to identify the potential long-term effects of adverse life experiences in relation to disorders other than posttraumatic stress disorder (e.g., major depressive disorder) could help validate experiences, reduce stigma, and further advance research on etiology and interventions.


Assuntos
Transtorno Depressivo Maior , Transtornos de Estresse Pós-Traumáticos , Humanos , Transtornos de Estresse Pós-Traumáticos/psicologia , Transtorno Depressivo Maior/psicologia , Acontecimentos que Mudam a Vida , Saúde Mental
19.
Int J Qual Stud Health Well-being ; 19(1): 2300873, 2024 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38184797

RESUMO

PURPOSE: As our ageing population is growing and diversifying, it is important to gain insight into the well-being of older migrants. However, the meanings of happiness can vary cross-culturally. Therefore, prior to exploring older migrants' happiness, their meaning-making of "happiness" should be explored. This way, cultural or individual variations can be considered when analysing older migrants' happiness. Not only migration background but also age could influence the meaning of well-being. For example, the meaning of well-being can change as people grow older. Therefore, both migration background and age are considered in exploring older migrants' meaning-making of happiness. METHODS: To do so, in-depth interviews with older migrants (n = 22) from various ethnicities were conducted in which their meaning-making of happiness was questioned via a semi-structured interview guide. RESULTS: After analysing the results via thematic analysis, three overarching themes are discussed: (1) happiness associations, (2) happiness-pursuing strategies, and (3) happiness obstructions. The analysis then further focuses on the role of migration background and ageing on the meaning-making of happiness. CONCLUSIONS: Participants' meaning-making of happiness seems strongly imbued with age-related references. On the contrary, the impact of migration background is rather limited. To explain this difference, the value of incorporating participants' life course experiences emerged.


Assuntos
Felicidade , Migrantes , Humanos , Adolescente , Envelhecimento , Etnicidade , Acontecimentos que Mudam a Vida
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