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1.
Cell ; 183(2): 308-314, 2020 10 15.
Artigo em Inglês | MEDLINE | ID: mdl-33064987

RESUMO

The 2020 Lasker Awards, a celebration of one of the most prestigious international prizes given to individuals for extraordinary contributions to Basic and Clinical Medical Research, Pubic Health, and Special Achievement, was cancelled because of the COVID-19 pandemic. Typically, essays on the awardees and their scientific and medical contributions are solicited and published in Cell in collaboration with the Lasker Committee. This year, the Lasker Committee commissioned an essay to reflect on the historic contributions that scientists and physicians have made to our understanding of immunology and virology, and future directions in medical and basic research that have been highlighted by COVID-19 pandemic.


Assuntos
Alergia e Imunologia , Betacoronavirus/imunologia , Infecções por Coronavirus/imunologia , Imunidade , Pneumonia Viral/imunologia , Alergia e Imunologia/história , Animais , Distinções e Prêmios , Citocinas/imunologia , História do Século XIX , História do Século XX , História do Século XXI , Humanos , Sistema Imunitário/citologia , Imunoglobulinas/genética , Imunoglobulinas/imunologia , Linfócitos/citologia , Pandemias , Vacinação/história
2.
S Afr Med J ; 110(8): 751-752, 2020 06 11.
Artigo em Inglês | MEDLINE | ID: mdl-32880300

RESUMO

In endeavouring to mitigate the spread of the SARS-CoV-2 virus, a concerning practice of spraying individuals with disinfectant via so-called 'disinfection tunnels' has come to light. The Allergy Society of South Africa supports the World Health Organization in strongly condemning all human spraying, owing to lack of efficacy and potential dangers, especially to patients with coexisting allergic conditions.


Assuntos
Anti-Infecciosos Locais/efeitos adversos , Infecções por Coronavirus/prevenção & controle , Desinfetantes/efeitos adversos , Desinfecção/métodos , Pandemias/prevenção & controle , Pneumonia Viral/prevenção & controle , Alergia e Imunologia , Anti-Infecciosos Locais/administração & dosagem , Betacoronavirus , Desinfetantes/administração & dosagem , Humanos , África do Sul , Organização Mundial da Saúde
3.
Nephrol Nurs J ; 47(4): 299-304, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32830935

RESUMO

The COVID-19 pandemic has caused certain immunological concepts to enter the public consciousness, as the scientific and health care communities, and the population in general, seek a path forward in this extraordinary time. Nephrology nurses are uniquely situated to assist their patients in understanding these concepts but may not feel confident in their own knowledge. The following is a high-level overview of basic immunology that can assist the nephrology nurse in the care and education of patients with kidney failure, as well as those in the community who may seek guidance and clarification of the issues that are inherent in the global response to COVID-19.


Assuntos
Alergia e Imunologia , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/imunologia , Humanos , Enfermagem em Nefrologia , Pandemias , Pneumonia Viral/epidemiologia , Pneumonia Viral/imunologia
5.
J Allergy Clin Immunol Pract ; 8(8): 2461-2473.e3, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32603900

RESUMO

Telemedicine adoption has rapidly accelerated since the onset of the COVID-19 pandemic. Telemedicine provides increased access to medical care and helps to mitigate risk by conserving personal protective equipment and providing for social/physical distancing to continue to treat patients with a variety of allergic and immunologic conditions. During this time, many allergy and immunology clinicians have needed to adopt telemedicine expeditiously in their practices while studying the complex and variable issues surrounding its regulation and reimbursement. Some concerns have been temporarily alleviated since March 2020 to aid with patient care in the setting of COVID-19. Other changes are ongoing at the time of this publication. Members of the Telemedicine Work Group in the American Academy of Allergy, Asthma & Immunology (AAAAI) completed a telemedicine literature review of online and Pub Med resources through May 9, 2020, to detail Pre-COVID-19 telemedicine knowledge and outline up-to-date telemedicine material. This work group report was developed to provide guidance to allergy/immunology clinicians as they navigate the swiftly evolving telemedicine landscape.


Assuntos
Infecções por Coronavirus/epidemiologia , Pneumonia Viral/epidemiologia , Telemedicina/organização & administração , Alergia e Imunologia/organização & administração , Betacoronavirus , Codificação Clínica , Segurança Computacional , Acesso aos Serviços de Saúde/organização & administração , Humanos , Hipersensibilidade/terapia , Controle de Infecções/organização & administração , Reembolso de Seguro de Saúde , Pandemias , Sociedades Médicas , Telemedicina/economia
7.
Scand J Immunol ; 92(4): e12941, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32697855

RESUMO

The Scandinavian Society for Immunology (SSI) was established with the purpose to advance the study of immunology in Scandinavia and to facilitate contacts between individuals and laboratories working within the field. To fulfill this the Society should organize scientific meetings and laboratory courses and take any other measure to support the development of immunology. A second objective was to establish contact and scientific exchange with other societies in Europe and overseas. By joining five national societies from the Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) into one umbrella society this has given SSI a more powerful voice in international organizations such as European Federation of Immunological Societies (EFIS) and International Union of Immunological Societies (IUIS). The Scandinavian Foundation for Immunology and the Scandinavian Journal of Immunology has greatly facilitated the annual meetings to be of international high quality and by attracting more participants. Thus, SSI provides a forum for Nordic immunologists to share their research results and to increase collaboration over the borders. In conclusion, the SSI has undoubtedly been and will hopefully continue to be a major strength for Scandinavian immunology.


Assuntos
Alergia e Imunologia , Sociedades Médicas/história , História do Século XX , História do Século XXI , Países Escandinavos e Nórdicos
8.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi ; 36(4): 376-382, 2020 Apr.
Artigo em Chinês | MEDLINE | ID: covidwho-595772

RESUMO

During the pandemic of coronavirus disease 2019 (COVID-19), the Chinese Ministry of Education put forward the requirement of turning offline education into online teaching to universities. Our department positively responded and rapidly mobilized to establish an online teaching system of medical immunology based on the small private online course (SPOC) model, which has a main body of the SPOC model with "video course as the main part, supplemented by online Q&A". The system also has feedback improvement sections of online discussion and chapter tests and evaluates the quality and effect of teaching with students' group display, course examination, and questionnaires. At the same time, the COVID-19 hotspot is also organically combined with immunological knowledge throughout the online teaching. In this process, our department continuously summarizes experiences and discovers problems. Herein, we generalize and sort out the exploration and practice of constructing the online teaching system, to carry out offline teaching after the pandemic and to continue this teaching model in the future, for reference and guidance.


Assuntos
Alergia e Imunologia , Infecções por Coronavirus , Coronavirus , Educação a Distância , Modelos Educacionais , Pandemias , Pneumonia Viral , Alergia e Imunologia/educação , Betacoronavirus , Infecções por Coronavirus/epidemiologia , Humanos , Internet , Pneumonia Viral/epidemiologia
17.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi ; 36(4): 376-382, 2020 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-32519674

RESUMO

During the pandemic of coronavirus disease 2019 (COVID-19), the Chinese Ministry of Education put forward the requirement of turning offline education into online teaching to universities. Our department positively responded and rapidly mobilized to establish an online teaching system of medical immunology based on the small private online course (SPOC) model, which has a main body of the SPOC model with "video course as the main part, supplemented by online Q&A". The system also has feedback improvement sections of online discussion and chapter tests and evaluates the quality and effect of teaching with students' group display, course examination, and questionnaires. At the same time, the COVID-19 hotspot is also organically combined with immunological knowledge throughout the online teaching. In this process, our department continuously summarizes experiences and discovers problems. Herein, we generalize and sort out the exploration and practice of constructing the online teaching system, to carry out offline teaching after the pandemic and to continue this teaching model in the future, for reference and guidance.


Assuntos
Alergia e Imunologia , Infecções por Coronavirus , Coronavirus , Educação a Distância , Modelos Educacionais , Pandemias , Pneumonia Viral , Alergia e Imunologia/educação , Betacoronavirus , Infecções por Coronavirus/epidemiologia , Humanos , Internet , Pneumonia Viral/epidemiologia
18.
Ital J Pediatr ; 46(1): 84, 2020 Jun 16.
Artigo em Inglês | MEDLINE | ID: mdl-32546234

RESUMO

The COVID-19 pandemic has surprised the entire population. The world has had to face an unprecedented pandemic. Only, Spanish flu had similar disastrous consequences. As a result, drastic measures (lockdown) have been adopted worldwide. Healthcare service has been overwhelmed by the extraordinary influx of patients, often requiring high intensity of care. Mortality has been associated with severe comorbidities, including chronic diseases. Patients with frailty were, therefore, the victim of the SARS-COV-2 infection. Allergy and asthma are the most prevalent chronic disorders in children and adolescents, so they need careful attention and, if necessary, an adaptation of their regular treatment plans. Fortunately, at present, young people are less suffering from COVID-19, both as incidence and severity. However, any age, including infancy, could be affected by the pandemic.Based on this background, the Italian Society of Pediatric Allergy and Immunology has felt it necessary to provide a Consensus Statement. This expert panel consensus document offers a rationale to help guide decision-making in the management of children and adolescents with allergic or immunologic diseases.


Assuntos
Alergia e Imunologia , Betacoronavirus , Consenso , Infecções por Coronavirus/terapia , Gerenciamento Clínico , Pandemias , Pneumonia Viral/terapia , Sociedades Médicas , Adolescente , Criança , Infecções por Coronavirus/epidemiologia , Tomada de Decisões , Humanos , Itália/epidemiologia , Pneumonia Viral/epidemiologia , Ensaios Clínicos Pragmáticos como Assunto/métodos
19.
PLoS Comput Biol ; 16(5): e1007757, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32453790

RESUMO

T cell epitope candidates are commonly identified using computational prediction tools in order to enable applications such as vaccine design, cancer neoantigen identification, development of diagnostics and removal of unwanted immune responses against protein therapeutics. Most T cell epitope prediction tools are based on machine learning algorithms trained on MHC binding or naturally processed MHC ligand elution data. The ability of currently available tools to predict T cell epitopes has not been comprehensively evaluated. In this study, we used a recently published dataset that systematically defined T cell epitopes recognized in vaccinia virus (VACV) infected C57BL/6 mice (expressing H-2Db and H-2Kb), considering both peptides predicted to bind MHC or experimentally eluted from infected cells, making this the most comprehensive dataset of T cell epitopes mapped in a complex pathogen. We evaluated the performance of all currently publicly available computational T cell epitope prediction tools to identify these major epitopes from all peptides encoded in the VACV proteome. We found that all methods were able to improve epitope identification above random, with the best performance achieved by neural network-based predictions trained on both MHC binding and MHC ligand elution data (NetMHCPan-4.0 and MHCFlurry). Impressively, these methods were able to capture more than half of the major epitopes in the top N = 277 predictions within the N = 767,788 predictions made for distinct peptides of relevant lengths that can theoretically be encoded in the VACV proteome. These performance metrics provide guidance for immunologists as to which prediction methods to use, and what success rates are possible for epitope predictions when considering a highly controlled system of administered immunizations to inbred mice. In addition, this benchmark was implemented in an open and easy to reproduce format, providing developers with a framework for future comparisons against new tools.


Assuntos
Alergia e Imunologia/normas , Epitopos de Linfócito T/imunologia , Antígenos de Histocompatibilidade Classe I/química , Algoritmos , Alelos , Animais , Área Sob a Curva , Automação , Epitopos de Linfócito T/química , Sistema Imunitário , Ligantes , Aprendizado de Máquina , Camundongos , Camundongos Endogâmicos C57BL , Redes Neurais de Computação , Peptídeos/química , Ligação Proteica , Proteoma , Curva ROC , Vírus Vaccinia
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