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1.
Arch Dermatol Res ; 316(6): 318, 2024 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-38822862

RESUMO

BACKGROUND: One common problem in various patient groups is excessive hair loss on the head. One such group is people struggling with hypothyroidism. The market for preparations for hair growth and hair loss prevention includes betulin. PURPOSE: This pilot study investigated its effect on hair loss in hypothyroid patients. STUDY DESIGN: The study included a group of hypothyroid patients and a control group of people without hypothyroidism. Participants were randomly divided into a group taking placebo and betulin. METHODS: Results were investigated using photographic assessment of hair, trichoscopy and subjective evaluation of participants. CONCLUSION: The study did not conclusively prove that betulin would contribute to the inhibition of hair loss or regrowth.


Assuntos
Cabelo , Hipotireoidismo , Triterpenos , Humanos , Projetos Piloto , Triterpenos/administração & dosagem , Triterpenos/farmacologia , Feminino , Adulto , Hipotireoidismo/tratamento farmacológico , Cabelo/crescimento & desenvolvimento , Cabelo/efeitos dos fármacos , Pessoa de Meia-Idade , Masculino , Alopecia/tratamento farmacológico , Óleos de Plantas/administração & dosagem , Resultado do Tratamento , Ácido Betulínico
2.
Sci Rep ; 14(1): 13436, 2024 06 11.
Artigo em Inglês | MEDLINE | ID: mdl-38862721

RESUMO

Cartilage-hair hypoplasia syndrome (CHH) is an autosomal recessive disorder frequently linked to n.72A>G (previously known as n.70A>G and n.71A>G), the most common RMRP variant worldwide. More than 130 pathogenic variants in this gene have already been described associated with CHH, and founder alterations were reported in the Finnish and Japanese populations. Our previous study in Brazilian CHH patients showed a high prevalence of n.197C>T variant (former n.195C>T and n.196C>T) when compared to other populations. The aim of this study was to investigate a possible founder effect of the n.197C>T variant in the RMRP gene in a series of CHH Brazilian patients. We have selected four TAG SNPs within chromosome 9 and genotyped the probands and their parents (23 patients previously described and nine novel). A common haplotype to the n.197C>T variant carriers was identified. Patients were also characterized for 46 autosomal Ancestry Informative Markers (AIMs). European ancestry was the most prevalent (58%), followed by African (24%) and Native American (18%). Our results strengthen the hypothesis of a founder effect for the n.197C>T variant in Brazil and indicate that this variant in the RMRP gene originated from a single event on chromosome 9 with a possible European origin.


Assuntos
Efeito Fundador , Cabelo , Doença de Hirschsprung , Osteocondrodisplasias , Polimorfismo de Nucleotídeo Único , Humanos , Brasil , Doença de Hirschsprung/genética , Masculino , Osteocondrodisplasias/genética , Osteocondrodisplasias/congênito , Feminino , Cabelo/anormalidades , RNA Longo não Codificante/genética , Haplótipos , Doenças da Imunodeficiência Primária/genética , Hipotricose/genética , Cromossomos Humanos Par 9/genética , Criança
3.
Sci Rep ; 14(1): 13569, 2024 06 12.
Artigo em Inglês | MEDLINE | ID: mdl-38866844

RESUMO

Revolutionizing construction, the concrete blend seamlessly integrates human hair (HH) fibers and millet husk ash (MHA) as a sustainable alternative. By repurposing human hair for enhanced tensile strength and utilizing millet husk ash to replace sand, these materials not only reduce waste but also create a durable, eco-friendly solution. This groundbreaking methodology not only adheres to established structural criteria but also advances the concepts of the circular economy, representing a significant advancement towards environmentally sustainable and resilient building practices. The main purpose of the research is to investigate the fresh and mechanical characteristics of concrete blended with 10-40% MHA as a sand substitute and 0.5-2% HH fibers by applying response surface methodology modeling and optimization. A comprehensive study involved preparing 225 concrete specimens using a mix ratio of 1:1.5:3 with a water-to-cement ratio of 0.52, followed by a 28 day curing period. It was found that a blend of 30% MHA and 1% HH fibers gave the best compressive and splitting tensile strengths at 28 days, which were 33.88 MPa and 3.47 MPa, respectively. Additionally, the incorporation of increased proportions of MHA and HH fibers led to reductions in both the dry density and workability of the concrete. In addition, utilizing analysis of variance (ANOVA), response prediction models were created and verified with a significance level of 95%. The models' R2 values ranged from 72 to 99%. The study validated multi-objective optimization, showing 1% HH fiber and 30% MHA in concrete enhances strength, reduces waste, and promotes environmental sustainability, making it recommended for construction.


Assuntos
Materiais de Construção , Cabelo , Milhetes , Resistência à Tração , Humanos , Materiais de Construção/análise , Cabelo/química , Milhetes/química , Teste de Materiais , Força Compressiva
4.
Arch Dermatol Res ; 316(6): 336, 2024 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-38844670

RESUMO

Telogen effluvium is characterized by excessive hair shedding usually following a stressful event. Ferritin has been used in clinical practice as a biomarker of nonanemic iron deficiency in cases of telogen effluvium. During the years of the COVID19 pandemic, telogen effluvium was reported as a part of post covid manifestations. As ferritin was also a biomarker for inflammation in cases with covid infection, this study was designed to evaluate the value of ferritin in cases with postcovid telogen effluvium one hundred patients recovering from covid 19 for 4-12 weeks were included in the study, detailed drug and laboratory history was obtained and serum ferritin level was measured. the mean serum level of ferritin among telogen effluvium patients was significantly lower than controls (68.52 ± 126 and 137 ± 137.597 ug/L respectively). Patients with telogen effluvium used significantly more azithromycin and ivermectin and significantly less vitamin C, D, lactoferrin and zinc than the controls Although serum ferritin is lower among telogen effluvium patients, it was still higher than the cutoff value for diagnosing nonanemic iron deficiency, we suggest that it will not be a good biomarkers in these cases. Our secondary outcomes showed that dietary supplements used during active infection such as vitamin C, D, lactoferrin and zinc might have a preventive value on postcovid hair loss, while azithromycin and ivermectin could have a negative long term effect on telogen effluvium.


Assuntos
Biomarcadores , COVID-19 , Suplementos Nutricionais , Ferritinas , Humanos , Ferritinas/sangue , COVID-19/sangue , COVID-19/diagnóstico , Biomarcadores/sangue , Feminino , Adulto , Masculino , Estudos de Casos e Controles , Pessoa de Meia-Idade , SARS-CoV-2 , Azitromicina/uso terapêutico , Ivermectina/uso terapêutico , Alopecia/diagnóstico , Alopecia/sangue , Alopecia/etiologia , Cabelo , Adulto Jovem
5.
BMC Public Health ; 24(1): 1502, 2024 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-38840150

RESUMO

BACKGROUND: A person's sense of coherence (SoC) is likely to affect coping when exposed to a life changing event like the COVID -19 pandemic, which impacted the older population especially hard, an age group that already suffers from a lot of mental illness. Thus, the aim of this study was to investigate the associations between SoC and mental health in older adults using both screening scales and hair cortisol concentrations (HCC). METHOD: A cross-sectional design studying a cohort of 70-80 years old, N = 260, set in Swedish primary care during the pandemic years 2021-2022. Instruments used are sense of coherence 13 (SoC-13), EQ-5D-3L, Geriatric depression scale 20 (GDS-20), Hospital anxiety and depression scale (HADS), and Perceived stress scale 10 (PSS-10). Sociodemography and factors concerning SoC, and mental health are explored. HCC are measured using radioimmunoassay. Outcome measures are factors independently associated with SoC. Linear regression models were performed with SoC as dependent variable, and priory path analyses explored whether associations with SoC were direct, or indirect via anxiety. RESULTS: SoC was significantly associated with anxiety (p < 0.001), perceived economic status (p = 0.003), belief in the future (p = 0.001), and perceived negative mental effect from the COVID -19 pandemic (p = 0.002). The latter was 96% indirectly associated with SoC (p < 0.001), whereas perceived economic status together with belief in the future was 82% directly associated with SoC (p = 0.17). HCC and sex were not significantly associated with SoC, but, noticeably, high HCC was equally distributed between women and men. Women reported significantly lower quality of life (p = 0.03), and more symptoms of anxiety (p = 0.001) and depression (p < 0.001). CONCLUSION: Anxiety, belief in the future, perceived negative effect on mental health due to the pandemic, and perceived economic status were significantly associated with SoC. Anxiety is suggested to be important in explaining the association between perceived negative mental effect from the COVID-19 pandemic and SoC. Women reported significantly poorer mental health and life quality than men.


Assuntos
COVID-19 , Cabelo , Hidrocortisona , Saúde Mental , Senso de Coerência , Humanos , COVID-19/psicologia , COVID-19/epidemiologia , Estudos Transversais , Masculino , Idoso , Cabelo/química , Feminino , Hidrocortisona/análise , Hidrocortisona/metabolismo , Idoso de 80 Anos ou mais , Suécia/epidemiologia , Ansiedade/epidemiologia , Depressão/epidemiologia , Depressão/psicologia
6.
Braz J Biol ; 84: e282174, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38836803

RESUMO

The elemental status of cattle is one of the important factors, which determine its growth, fertility, fetal development, meat and dairy production, etc. Therefore, the study of content of different elements in cattle organs and tissues and its correlation with cattle characteristics and diet is urgent task. It is also important to develop intravital and low-invasive methods to analyze element content in cattle to regulate its diet during lifetime. In the present work, we have studied the content and distribution of manganese in Hereford cattle from an ecologically clean zone of Western Siberia (Russia). 252 samples were taken from 31 bulls aged 15-18 months. They were collected from various livestock farms in the region and analyzed using atomic absorption spectrophotometry (organs and muscle tissue) and inductively coupled plasma atomic emission spectrometry (hair). The median values of manganese concentration obtained in natural moisture for hair, heart, kidneys, liver, lungs, muscles, spleen, testes, and brain were 25, 0.37, 1.0, 2.6, 0.4, 0.2, 0.4, 0.5, and 0.5 ppm. Accordingly, the concentration of manganese differs significantly in the organs and tissues of animals (H = 188.6, df = 8, p <0.0001). Statistically significant associations of manganese were revealed in pairs: liver-testis, hair-testis, spleen-testis, and heart-brain. The classification of organs and tissues of animals according to the level of content and variability of manganese is carried out. The concentration of manganese in the body is not uniform, most of all it is deposited in the hair and excretory organs of the liver and kidneys. In other organs and muscle tissues, the distribution of manganese is more even and is in the range of 0.2-0.5 ppm. The resulting ranges can be used as a guideline for Hereford cattle bred in Western Siberia.


Assuntos
Manganês , Espectrofotometria Atômica , Animais , Manganês/análise , Bovinos , Masculino , Sibéria , Cabelo/química , Distribuição Tecidual
7.
Skin Res Technol ; 30(6): e13733, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38887131

RESUMO

BACKGROUND: Fourier Transform Infrared (FTIR) spectroscopy has emerged as a powerful analytical tool in medical research, offering non-invasive and precise examination of the molecular composition of biological samples. The primary objective of this review is to underscore the benefits of FTIR spectroscopy in medicinal research, emphasizing its ability to delineate molecular fingerprints and assist in the identification of biochemical structures and key peaks in biological samples. METHODS: This review comprehensively explores the diverse applications of FTIR spectroscopy in medical investigations, with a specific focus on its utility in analyzing tissue, cells, and hair samples. Various sources, including Google Scholar, PubMed, WorledCat and Scopus, were utilized to conduct this comprehensive literature review. RESULTS: Recent advancements showcase the versatility of FTIR spectroscopy in elucidating cellular and molecular processes, facilitating disease diagnostics, and enabling treatment monitoring. Notably, FTIR spectroscopy has found significant utility in clinical assessment, particularly in screening counterfeit medicines, owing to its user-friendly operation and minimal sample preparation requirements. Furthermore, customs officials can leverage this technique for preliminary analysis of suspicious samples. CONCLUSION: This review aims to bridge a gap in the literature and serve as a valuable resource for future research endeavors in FTIR spectroscopy within the medical domain. Additionally, it presents fundamental concepts of FTIR spectroscopy and spectral data interpretation, highlighting its utility as a tool for molecular analysis using Mid-Infrared (MIR) radiation.


Assuntos
Cabelo , Espectroscopia de Infravermelho com Transformada de Fourier/métodos , Humanos , Cabelo/química , Pesquisa Biomédica/métodos , Pele/química , Pele/patologia
8.
J Med Internet Res ; 26: e49581, 2024 Jun 17.
Artigo em Inglês | MEDLINE | ID: mdl-38885014

RESUMO

BACKGROUND: The emergence of the COVID-19 pandemic rapidly accelerated the need and implementation of digital innovations, especially in medicine. OBJECTIVE: To gain a better understanding of the stress associated with digital transformation in physicians, this study aims to identify working conditions that are stress relevant for physicians and differ in dependence on digital transformation. In addition, we examined the potential role of individual characteristics (ie, age, gender, and actual implementation of a digital innovation within the last 3 years) in digitalization-associated differences in these working conditions. METHODS: Cross-sectional web-based questionnaire data of 268 physicians (mean age 40.9, SD 12.3 y; n=150, 56% women) in Germany were analyzed. Physicians rated their chronic stress level and 11 relevant working conditions (ie, work stressors such as time pressure and work resources such as influence on sequence) both before and after either a fictional or real implementation of a relevant digital transformation at their workplace. In addition, a subsample of individuals (60; n=33, 55% women) submitted self-collected hair samples for cortisol analysis. RESULTS: The stress relevance of the selected working conditions was confirmed by significant correlations with self-rated chronic stress and hair cortisol levels (hair F) within the sample, all of them in the expected direction (P values between .01 and <.001). Multilevel modeling revealed significant differences associated with digital transformation in the rating of 8 (73%) out of 11 working conditions. More precisely, digital transformation was associated with potentially stress-enhancing effects in 6 working conditions (ie, influence on procedures and complexity of tasks) and stress-reducing effects in 2 other working conditions (ie, perceived workload and time pressure). Younger individuals, women, and individuals whose workplaces have implemented digital innovations tended to perceive digitalization-related differences in working conditions as rather stress-reducing. CONCLUSIONS: Our study lays the foundation for future hypothesis-based longitudinal research by identifying those working conditions that are stress relevant for physicians and prone to differ as a function of digital transformation and individual characteristics.


Assuntos
COVID-19 , Estresse Ocupacional , Médicos , Humanos , Estudos Transversais , Feminino , Adulto , Masculino , Médicos/psicologia , Médicos/estatística & dados numéricos , COVID-19/psicologia , Estresse Ocupacional/psicologia , Pessoa de Meia-Idade , Alemanha , Inquéritos e Questionários , SARS-CoV-2 , Hidrocortisona/análise , Local de Trabalho/psicologia , Cabelo , Estresse Psicológico/psicologia , Pandemias , Carga de Trabalho/psicologia
10.
Am J Case Rep ; 25: e943909, 2024 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-38889103

RESUMO

BACKGROUND A 52-year-old male patient presented with symptoms of chronic cough and persistent tracheal irritation 26 years after surgical closure of a tracheostoma, supported by an autologous auricular cartilage graft and cutaneous transplant. At the initial clinical presentation, the patient was an active smoker, with a cumulative dose of 31 pack years. CASE REPORT Bronchoscopy revealed endotracheal hair growth and local inflammation at the graft site. Initial anti-inflammatory, antimycotic, and antibacterial therapy was administered, followed by endoscopic structure remodeling. There were multiple recurrences with similar symptoms, showing isolated hair growth, without inflammation. Annual endoscopic restructuring sessions were indicated, and the patient experienced them as highly relieving. Recurrent hair growth was finally terminated by argon plasma laser-coagulation and after smoking cessation. We hypothesize that the onset of hair growth was triggered by the patient's cigarette smoking. CONCLUSIONS Endotracheal hair growth is a potential complication of autograft-supported tracheal restructuring. The initial administration of antimicrobial and anti-inflammatory medication, combined with endoscopic restructuring, could have contained the active inflammation; the application of argon plasma laser-coagulation finally stopped the hair growth. Smoking is associated with the upregulation of molecular signaling pathways in the respiratory epithelium, which can stimulate hair follicles, such as sonic hedgehog protein, WNT-1/ß-catenin, and epidermal growth factor receptor.


Assuntos
Cabelo , Humanos , Masculino , Pessoa de Meia-Idade , Broncoscopia , Traqueostomia , Traqueia , Fumar/efeitos adversos , Cartilagem da Orelha , Coagulação com Plasma de Argônio , Doenças da Traqueia/etiologia
11.
J Oleo Sci ; 73(6): 825-837, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38825536

RESUMO

Hair is important to our appearance as well as to protect our heads. Human hair mainly consists of proteins (80-85%), melanin pigments (0-5%), water (10-13%), and lipids (1-6%). The physicochemical properties of hair have been studied for over 100 years. However, they are not yet thoroughly understood. In this review, recent progress and the latest findings are summarized from the following three perspectives: structural characteristics, delivery and distribution of active ingredients, and hair as a template. The structural characteristics of hair have been mainly investigated by microscopic and/or spectroscopic techniques such as atomic force microscopy integrated with infrared spectroscopy (AFM-IR) and rheological measurements. The distribution of active ingredients has been generally evaluated through techniques such as nanoscale secondary ion mass spectrometry (NanoSIMS). And finally, attempts to explore the potential of hair to be used as a substrate for flexible device fabrication will be introduced.


Assuntos
Cabelo , Cabelo/química , Humanos , Microscopia de Força Atômica , Melaninas , Fenômenos Químicos , Espectrometria de Massa de Íon Secundário/métodos , Reologia , Espectrofotometria Infravermelho/métodos , Lipídeos/análise , Lipídeos/química , Água , Proteínas/análise
12.
Dev Psychobiol ; 66(5): e22512, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38837366

RESUMO

The current study examined associations between parental adversities as experienced in adolescence and hair cortisol concentration (HCC) 26 years later (n = 47). Specifically, bivariate correlations and linear regressions were used to examine harsh parenting as well as parental economic pressure, emotional distress, and body mass index (BMI) when their adolescent was between 15 and 16 years old (parent average age 43). HCC was measured when the adolescent was an adult (average 42 years old), at a similar age to when their parent(s) first participated in the study. We also assessed their economic pressure, emotional distress, obesity, and perceived stress in adulthood. For results across generations, parental economic pressure experienced during adolescence was significantly related to HCC when these adolescents were adults. None of the adult economic pressure, emotional distress, BMI, and perceived stress variables were associated with their HCC. Interestingly, there were significant associations among adult perceived stress, economic pressure, emotional distress, and obesity. Thus, the association between parental economic pressure and adult HCC is independent of adult adversities. Results highlight early economic adversity as a possible childhood stressor that has implications throughout the life course.


Assuntos
Experiências Adversas da Infância , Cabelo , Hidrocortisona , Humanos , Cabelo/química , Feminino , Masculino , Hidrocortisona/metabolismo , Hidrocortisona/análise , Adulto , Adolescente , Estresse Psicológico/metabolismo , Poder Familiar , Índice de Massa Corporal , Angústia Psicológica , Obesidade/metabolismo
13.
PLoS One ; 19(6): e0304605, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38861499

RESUMO

Canine Alopecia X is a non-inflammatory hair loss disorder of unknown etiology that predominantly affects German Spitz dogs. Treatment modalities include hormone and/or melatonin supplementation and low trauma microneedling. Melatonin influences hair growth and pigmentation in several species and presents a low risk of adverse effects when used in dogs with Alopecia X. Photobiomodulation (PBM) is frequently used in human androgenetic alopecia and alopecia areata; despite this, PBM remains unexplored in canine Alopecia X. To address this knowledge gap, sixty dogs of both sexes will be randomly assigned to three groups: (i) melatonin only group (3 mg/Kg, n = 20); (ii) PBM only group (diode laser, wavelength 660nm, 100mw power, with 3 J/point, 2 sessions/week for 3 months, n = 20); (ii) PBM + melatonin group (n = 20). The objective is to determine the potential of PBM alone or in conjunction with melatonin supplementation in promoting hair regrowth (hair density and diameter) by means of dermatoscopy and planimetry over a period of 90 days.


Assuntos
Alopecia , Terapia com Luz de Baixa Intensidade , Melatonina , Animais , Melatonina/uso terapêutico , Melatonina/farmacologia , Cães , Terapia com Luz de Baixa Intensidade/métodos , Alopecia/tratamento farmacológico , Alopecia/radioterapia , Alopecia/veterinária , Masculino , Feminino , Método Duplo-Cego , Doenças do Cão/radioterapia , Cabelo/crescimento & desenvolvimento , Cabelo/efeitos dos fármacos
15.
Dev Psychobiol ; 66(5): e22502, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38807271

RESUMO

Environmental influences before and during pregnancy significantly impact offspring development. This study investigates open research questions regarding the associations between maternal early life stress (ELS), prenatal psychosocial stress, prenatal hair cortisol (HC), and birth outcomes in Argentinian women. Data on ELS, prenatal life events, HC (two samples representing first and second half of pregnancy), and birth outcomes were collected from middle-class Argentinian women (N = 69) upon delivery. Linear mixed models indicated that HC increased from the first half to the second half of pregnancy with considerable variability in the starting values and slopes between individuals. Mothers who experienced more ELS, were taller, or more educated, tended to show lower increases in HC. Older age was positively related to HC increases. Our data did not suggest an interaction between ELS and prenatal life events in relation to HC. We found that the change in HC was most likely negatively associated with birth weight. Our data are most compatible with either a weak or the absence of an association between ELS or prenatal life events and absolute values of HC. Mothers with stronger increases in hair cortisol tended to have newborns with slightly lower birth weight. Hence, ELS and birthweight may either have been related to changes in cortisol exposure during pregnancy or to factors that influence accumulation or retention of cortisol in hair.


Assuntos
Peso ao Nascer , Cabelo , Hidrocortisona , Efeitos Tardios da Exposição Pré-Natal , Estresse Psicológico , Humanos , Feminino , Gravidez , Hidrocortisona/metabolismo , Hidrocortisona/análise , Estresse Psicológico/metabolismo , Adulto , Cabelo/química , Argentina , Peso ao Nascer/fisiologia , Recém-Nascido , Resultado da Gravidez , Adulto Jovem , Mães
16.
Arch Dermatol Res ; 316(6): 290, 2024 May 29.
Artigo em Inglês | MEDLINE | ID: mdl-38809465

RESUMO

Enz_MoriL is a naturally occurring substance extracted from the leaves of Morus alba L. through enzymatic conversion. Historically, M. alba L. has been recognized for its potential to promote hair regrowth. However, the precise mechanism by which Enz_MoriL affects human hair follicle dermal papilla cells (hDPCs) remains unclear. The aim of this study was to investigate the molecular basis of Enz_MoriL's effect on hair growth in hDPCs. Interferon-gamma (IFN-γ) was used to examine the effects of Enz_MoriL on hDPCs during the anagen and catagen phases, as well as under conditions mimicking alopecia areata (AA). Enz_MoriL demonstrated the ability to promote cell proliferation in both anagen and catagen stages. It increased the levels of active ß-catenin in the catagen stage induced by IFN-γ, leading to its nuclear translocation. This effect was achieved by increasing the phosphorylation of GSK3ß and decreasing the expression of DKK-1. This stimulation induced proliferation in hDPCs and upregulated the expression of the Wnt family members 3a, 5a, and 7a at the transcript level. Additionally, Enz_MoriL suppressed JAK1 and STAT3 phosphorylation, contrasting with IFN-γ, which induced them in the catagen stage. In conclusion, Enz_MoriL directly induced signals for anagen re-entry into hDPCs by affecting the Wnt/ß-catenin pathway and enhancing the production of growth factors. Furthermore, Enz_MoriL attenuated and reversed the interferon-induced AA-like environment by blocking the JAK-STAT pathway in hDPCs.


Assuntos
Alopecia em Áreas , Proliferação de Células , Folículo Piloso , Interferon gama , Via de Sinalização Wnt , beta Catenina , Humanos , Folículo Piloso/efeitos dos fármacos , Folículo Piloso/citologia , Folículo Piloso/metabolismo , Proliferação de Células/efeitos dos fármacos , Via de Sinalização Wnt/efeitos dos fármacos , Interferon gama/metabolismo , beta Catenina/metabolismo , Alopecia em Áreas/metabolismo , Alopecia em Áreas/tratamento farmacológico , Alopecia em Áreas/patologia , Células Cultivadas , Glicogênio Sintase Quinase 3 beta/metabolismo , Peptídeos e Proteínas de Sinalização Intercelular/metabolismo , Janus Quinases/metabolismo , Derme/citologia , Derme/efeitos dos fármacos , Fosforilação/efeitos dos fármacos , Fator de Transcrição STAT3/metabolismo , Cabelo/efeitos dos fármacos , Cabelo/crescimento & desenvolvimento , Proteína Wnt-5a/metabolismo , Janus Quinase 1/metabolismo , Transdução de Sinais/efeitos dos fármacos , Fatores de Transcrição STAT/metabolismo
17.
Nutrients ; 16(10)2024 May 20.
Artigo em Inglês | MEDLINE | ID: mdl-38794776

RESUMO

BACKGROUND: Functional Gastrointestinal Disorders (FGIDs) present a higher prevalence in individuals with Neurodevelopmental Disorders (NDDs). The Stress System and the Gut-Brain axis (GBA) may mediate these relations. We aimed to assess the prevalence and profile of FGIDs in a clinical sample of children with Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD) compared to typically developing children (TD) as well as to investigate possible relations between stress-related biomarkers and internalizing/externalizing problems in children with NDDS. METHODS: In total, 120 children, aged between 4 and 12 years old, formed three groups (N = 40, each): ADHD, ASD and TD. Salivary cortisol, hair cortisol and serum leptin were measured. RESULTS: The ASD group had more FGID problems than the TD group (p = 0.001). The ADHD and ASD groups had higher total internalizing/externalizing problems than the TD group (p < 0.0001, p < 0.0001, p = 0.005, respectively). Children with FGIDs showed more total, internalizing and externalizing problems compared to children without FGIDs (p < 0.0001, p < 0.0001, p = 0.041, respectively). The ADHD group showed lower AUCg values (p < 0.0001), while the hair cortisol was higher for the TD group (p < 0.0001). CONCLUSION: In conclusion, children with NDDs had more FGID symptoms and present higher internalizing and externalizing problems. Children with ADHD and FGIDs had more internalizing problems compared to those without FGIDs. No differences in stress-related biomarkers were shown to differentiate children with NDDs with and without FGIDs. Future prospective studies including a greater number of children may elucidate the biological pathways linking these comorbidities.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Transtorno do Espectro Autista , Gastroenteropatias , Cabelo , Hidrocortisona , Leptina , Saliva , Humanos , Criança , Hidrocortisona/sangue , Hidrocortisona/análise , Hidrocortisona/metabolismo , Cabelo/química , Transtorno do Deficit de Atenção com Hiperatividade/sangue , Leptina/sangue , Leptina/análise , Leptina/metabolismo , Feminino , Masculino , Saliva/química , Pré-Escolar , Gastroenteropatias/sangue , Gastroenteropatias/psicologia , Gastroenteropatias/epidemiologia , Transtorno do Espectro Autista/sangue , Transtorno do Espectro Autista/psicologia , Transtorno do Espectro Autista/metabolismo , Biomarcadores/sangue , Prevalência
19.
Molecules ; 29(10)2024 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-38792149

RESUMO

This narrative review aims to examine the therapeutic potential and mechanism of action of plant extracts in preventing and treating alopecia (baldness). We searched and selected research papers on plant extracts related to hair loss, hair growth, or hair regrowth, and comprehensively compared the therapeutic efficacies, phytochemical components, and modulatory targets of plant extracts. These studies showed that various plant extracts increased the survival and proliferation of dermal papilla cells in vitro, enhanced cell proliferation and hair growth in hair follicles ex vivo, and promoted hair growth or regrowth in animal models in vivo. The hair growth-promoting efficacy of several plant extracts was verified in clinical trials. Some phenolic compounds, terpenes and terpenoids, sulfur-containing compounds, and fatty acids were identified as active compounds contained in plant extracts. The pharmacological effects of plant extracts and their active compounds were associated with the promotion of cell survival, cell proliferation, or cell cycle progression, and the upregulation of several growth factors, such as IGF-1, VEGF, HGF, and KGF (FGF-7), leading to the induction and extension of the anagen phase in the hair cycle. Those effects were also associated with the alleviation of oxidative stress, inflammatory response, cellular senescence, or apoptosis, and the downregulation of male hormones and their receptors, preventing the entry into the telogen phase in the hair cycle. Several active plant extracts and phytochemicals stimulated the signaling pathways mediated by protein kinase B (PKB, also called AKT), extracellular signal-regulated kinases (ERK), Wingless and Int-1 (WNT), or sonic hedgehog (SHH), while suppressing other cell signaling pathways mediated by transforming growth factor (TGF)-ß or bone morphogenetic protein (BMP). Thus, well-selected plant extracts and their active compounds can have beneficial effects on hair health. It is proposed that the discovery of phytochemicals targeting the aforementioned cellular events and cell signaling pathways will facilitate the development of new targeted therapies for alopecia.


Assuntos
Alopecia , Cabelo , Compostos Fitoquímicos , Extratos Vegetais , Extratos Vegetais/farmacologia , Extratos Vegetais/química , Alopecia/tratamento farmacológico , Alopecia/prevenção & controle , Humanos , Compostos Fitoquímicos/farmacologia , Compostos Fitoquímicos/química , Animais , Cabelo/efeitos dos fármacos , Cabelo/crescimento & desenvolvimento , Folículo Piloso/efeitos dos fármacos , Folículo Piloso/metabolismo , Folículo Piloso/crescimento & desenvolvimento , Proliferação de Células/efeitos dos fármacos
20.
Arch Dermatol Res ; 316(5): 190, 2024 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-38775976

RESUMO

Hair is a biofilament with unique multi-dimensional values. In human, in addition to physiologic impacts, hair loss and hair related disorders can affect characteristic features, emotions, and social behaviors. Despite significant advancement, there is a dire need to explore alternative novel therapies with higher efficacy, less side effects and lower cost to promote hair growth to treat hair deficiency. Glucocorticoid-induced leucine zipper (GILZ) is a protein rapidly induced by glucocorticoids. Studies from our group and many others have suggested that a synthetic form of GILZ, TAT-GILZ, a fusion peptide of trans-activator of transcription and GILZ, can function as a potent regulator of inflammatory responses, re-establishing and maintaining the homeostasis. In this study, we investigate whether TAT-GILZ could promote and contribute to hair growth. For our pre-clinical model, we used 9-12 week-old male BALB/c and nude (athymic, nu/J) mice. We applied TAT-GILZ and/or TAT (vehicle) intradermally to depilated/hairless mice. Direct observation, histological examination, and Immunofluorescence imaging were used to assess the effects and compare different treatments. In addition, we tested two current treatment for hair loss/growth, finasteride and minoxidil, for optimal evaluation of TAT-GILZ in a comparative fashion. Our results showed, for the first time, that synthetic TAT-GILZ peptide accelerated hair growth on depilated dorsal skin of BALB/c and induced hair on the skin of athymic mice where hair growth was not expected. In addition, TAT-GILZ was able to enhance hair follicle stem cells and re-established the homeostasis by increasing counter inflammatory signals including higher regulatory T cells and glucocorticoid receptors. In conclusion, our novel findings suggest that reprofiling synthetic TAT-GILZ peptide could promote hair growth by increasing hair follicle stem cells and re-establishing homeostasis.


Assuntos
Alopecia , Folículo Piloso , Cabelo , Fatores de Transcrição , Animais , Masculino , Camundongos , Cabelo/crescimento & desenvolvimento , Cabelo/efeitos dos fármacos , Folículo Piloso/efeitos dos fármacos , Folículo Piloso/crescimento & desenvolvimento , Humanos , Alopecia/tratamento farmacológico , Fatores de Transcrição/genética , Fatores de Transcrição/metabolismo , Camundongos Endogâmicos BALB C , Proteínas Recombinantes de Fusão/farmacologia , Proteínas Recombinantes de Fusão/administração & dosagem , Camundongos Nus , Camundongos Pelados , Modelos Animais de Doenças , Glucocorticoides/farmacologia
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