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1.
Clin Plast Surg ; 47(1): 119-130, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31739888

RESUMO

This article presents the authors' experience with the use of fat grafting via the Coleman technique, for the adjuvant treatment of facial burn wounds and their sequelae. It demonstrates the regenerative effects of fat injected under the wound and/or the scar as well as of fat delivered to the debrided surface of the wound and to the surface of the scar after laser treatment or microneedling.


Assuntos
Tecido Adiposo/transplante , Queimaduras/complicações , Queimaduras/cirurgia , Cicatriz/cirurgia , Traumatismos Faciais/cirurgia , Procedimentos Cirúrgicos Reconstrutivos , Cicatriz/etiologia , Desbridamento , Humanos , Transplante Autólogo
2.
Clin Plast Surg ; 47(1): 131-138, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31739889

RESUMO

Autologous fat grafting has become more and more popular among plastic surgeons in the last few years due to recent discoveries on the mesenchymal stem cells stored in the harvested fat. These cells have a great regenerative potential and have the ability to restore the damaged tissues. The authors focused their practice on the treatment of the facial scars (derived from burns, trauma, degenerative diseases, and radiotherapy) and confirm that lipofilling is an excellent solution because it is able to improve the quality of the damaged tissues in terms of better scar color, pliability, thickness, relief, itching, pain, scar vascularization, and pigmentation.


Assuntos
Tecido Adiposo/transplante , Cicatriz/cirurgia , Traumatismos Faciais/cirurgia , Procedimentos Cirúrgicos Reconstrutivos , Queimaduras/complicações , Queimaduras/cirurgia , Cicatriz/etiologia , Traumatismos Faciais/complicações , Humanos , Transplante Autólogo
3.
Clin Plast Surg ; 47(1): 139-145, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31739890

RESUMO

Fat grafting is as a unique regenerative filler with soluble factors and progenitor cells that may remodel scar tissue in an easy yet effective way. A combination of microfat grafting, lipococoncentrate injection, scar subcision, and platelet-rich plasma supplementation may be used to treat the majority of facial scars. The lipoconcentrate technique condenses the lipoaspirate to a progenitor cell-rich fluid of low volume by a combination of centrifugation and emulsification steps. In this article, the authors' methods for scar treatment by fat grafting are discussed. Choice of technique for facial scars, precise indications, and contraindications are introduced.


Assuntos
Tecido Adiposo/transplante , Cicatriz/cirurgia , Traumatismos Faciais/cirurgia , Lipectomia/métodos , Plasma Rico em Plaquetas , Cicatriz/etiologia , Traumatismos Faciais/complicações , Humanos , Rejuvenescimento , Células-Tronco
4.
J Surg Res ; 245: 31-44, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31400575

RESUMO

Treatment of full-thickness skin wounds with minimal scarring and complete restoration of native tissue properties still exists as a clinical challenge. A bilayer skin substitute was fabricated by coating human amniotic membrane (AM) with electrospun silk fibroin nanofibers, and its in vivo biological behavior was studied using murine full-thickness skin wound model. Donut-shaped silicon splints were utilized to prevent wound contraction in mouse skin and simulate re-epithelialization, which is the normal path of human wound healing. Skin regeneration using the bilayer scaffold was compared with AM and untreated defect after 30 d. Tissue samples were taken from healed wound areas and investigated through histopathological and immunohistochemical staining to visualize involucrin (IVL), P63, collagen I, CD31, and vascular endothelial growth factor. In addition, mRNA expression of IVL, P63, interleukin-6, and cyclooxygenase-2 was studied. The application of bilayer scaffold resulted in the best epidermal and dermal regeneration, demonstrated by histopathological examination and molecular analysis. In regenerated wounds of the bilayer scaffold group, the mRNA expression levels of inflammatory markers (interleukin-6 and cyclooxygenase-2) were downregulated, and the expression pattern of keratinocyte markers (IVL and P63) at both mRNA and protein levels was more similar to native tissue in comparison with AM and no-treatment groups. There was no significant difference in the expression level of collagen I, CD31, and vascular endothelial growth factor among different groups. Conclusively, these promising results serve as a supporting evidence for proceeding to clinical phase to examine the capacity of this bilayer scaffold for human skin regeneration.


Assuntos
Cicatriz/prevenção & controle , Reepitelização , Pele Artificial , Pele/lesões , Ferimentos e Lesões/terapia , Animais , Cicatriz/etiologia , Modelos Animais de Doenças , Feminino , Fibroínas/química , Humanos , Camundongos , Nanofibras/química , Tecidos Suporte/química , Ferimentos e Lesões/complicações
5.
Pan Afr Med J ; 33: 246, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31692840

RESUMO

Buruli ulcer is infectious necrotizing panniculitis due to Mycobacterium ulcerans. Buruli ulcer is healed by leaving dystrophic, fibrous and retractile scars. On these scars can occur long-term squamous cell carcinoma. We report the first case of squamous cell carcinoma occurring on healing of Buruli ulcer. A 32-year-old woman with Buruli ulcer who has been cured for about 10 years is seen for ulcero-bulging knee swelling. The examination had revealed a large swelling of about ten centimeters in diameter, ulcero-budding, with an easily bleeding cauliflower appearance. The diagnosis of squamous cell carcinoma being retained without metastasis, resection of the tumor with scarring after one month without chemotherapy. There was no recurrence after six months of decline. The epidemiology of Buruli ulcer, responsible for scarring, explains the young age of our patient and the localization of carcinoma on the limb. The carcinomatous degeneration of scars, especially the scars of old burns, is constantly reported. The characteristics of Buruli ulcer scars, which bring them closer to burn scars, may explain why they are particularly affected by carcinomatous degeneration. One could also mention the chronicity of the wound in this infection, or wonder if the mycobacteria itself could play a role in carcinogenesis. This observation is, in our opinion, an alarm signal. We must fear an outbreak of cases in the years to come. To this end, preventive measures should already be taken by sensitizing the patients for an early consultation before any modification of their scars. After recovery, Buruli ulcer seems to present a risk of long-term evolution to a cancer. The scars of this condition, which could be considered precancerous lesions.


Assuntos
Úlcera de Buruli/complicações , Carcinoma de Células Escamosas/diagnóstico , Cicatriz/complicações , Adulto , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/cirurgia , Cicatriz/etiologia , Costa do Marfim , Feminino , Humanos
6.
Kathmandu Univ Med J (KUMJ) ; 17(65): 14-19, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31734672

RESUMO

Background Acne vulgaris has considerable impact on physical and psychological health. Isotretinoin is considered most effective drug available for acne therapy but with limited acceptance because of its adverse effects. Antihistamine inhibits inflammatory mediators, Propionibacterium acne induced itching, reduction of squalene and sebum in sebocyte, reduces anxiety and further lessens hormonal derangement and inhibits mast cell induced fibrosis and scars. Clinical relevance is lacking in the use of antihistamine in the treatment of acne and its potential efficacy needs to be clarified. Objective To evaluate the efficacy and safety of combining isotretinoin and antihistamine compare to isotretinoin alone in patients with moderate to severe acne at week 12. Method One hundred patients with moderate to severe acne were included in this randomised, controlled comparative study. Fifty patients were treated with isotretinoin and 50 patients were treated with additional antihistamine, levocetirizine and assessment was done at baseline, 4, 8 and 12 weeks of treatment. Result At week 12, compared to isotretinoin only group, combination of isotretinoin and levocetirizine group showed more statistically significant decrease in score of global acne grading system (51.0 vs. 38.5%) and acne lesion counts (non-inflammatory lesion: 63.2 vs. 44.5%; inflammatory lesions: 75.9 vs. 62.7%; total lesions: 66.07 vs. 48.7%; all p< 0.05). Flaring up of acne occurred less frequently and adverse effects were more tolerable in levocetirizine group. Conclusion Use of antihistamine with isotretinoin provides synergic effect while minimizing the side effect of isotretinoin and greater clearance of the lesion and scars.


Assuntos
Acne Vulgar/tratamento farmacológico , Antagonistas dos Receptores Histamínicos/uso terapêutico , Isotretinoína/uso terapêutico , Acne Vulgar/complicações , Adolescente , Adulto , Cetirizina/efeitos adversos , Cetirizina/uso terapêutico , Cicatriz/etiologia , Fármacos Dermatológicos/efeitos adversos , Fármacos Dermatológicos/uso terapêutico , Quimioterapia Combinada/efeitos adversos , Quimioterapia Combinada/normas , Feminino , Antagonistas dos Receptores Histamínicos/efeitos adversos , Humanos , Isotretinoína/efeitos adversos , Masculino , Exame Físico , Resultado do Tratamento
7.
Plast Reconstr Surg ; 144(4): 659e-668e, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31568312

RESUMO

BACKGROUND: Botulinum toxin type A (BTxA) injection is effective for surgical scar prevention. Although some studies have aimed to confirm the efficacy of BTxA injection at different time points, none has been conducted to determine the most appropriate timing of injection for scar management. The authors predicted that the injection of BTxA at different times during the wound healing process would cause differing scar quality improvement and clarify unknown molecular mechanisms. METHODS: The study included adults who underwent thyroidectomy. All patients received paralesional BTxA injections on the day of the surgery on either the right or left side of the operative site. The same dose was injected on the noninjected side by means of the same method after 2 weeks. At 2, 4, 12, and 24 weeks postoperatively, the modified Stony Brook Scar Evaluation Scale, visual analogue scale, and erythema index were used for objective, subjective, and quantitative evaluations of the scar. At week 24 postoperatively, a quantitative scar assessment was performed with respect to the erythema index, skin elasticity, melanin index, and friction. RESULTS: On objective evaluation of the scar and patient satisfaction at 24 weeks postoperatively, the operation-day injection side showed better outcomes than the 2-week-postoperative injection side. These differences were significant from postoperative week 4. In the final quantitative scar assessment at postoperative week 24, significant improvements were observed in the erythema index and skin elasticity. CONCLUSION: These results suggest that immediate postoperative BTxA injection is more effective for thyroidectomy scar management in terms of erythema, skin elasticity, and patient satisfaction. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.


Assuntos
Toxinas Botulínicas Tipo A/administração & dosagem , Cicatriz/etiologia , Cicatriz/prevenção & controle , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Tireoidectomia/efeitos adversos , Cicatrização/efeitos dos fármacos , Adulto , Idoso , Feminino , Humanos , Injeções Intralesionais , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Fatores de Tempo
8.
Hand Clin ; 35(4): 457-466, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31585607

RESUMO

Burns are devastating injuries that cause significant morbidity, emotional distress, and decreased quality of life. Advances in care have improved survival and functional outcomes; however, burns remain a major public health problem in developing countries. More than 95% of burns occur in low- and middle-income countries, where access to basic health care is limited. The upper extremity is involved in the majority of severe burn injuries. The purpose of this article is to review upper extremity burn epidemiology, risk factors, prevention strategies, and treatment options in resource-limited settings.


Assuntos
Queimaduras/cirurgia , Países em Desenvolvimento , Extremidade Superior/lesões , Extremidade Superior/cirurgia , Queimaduras/epidemiologia , Cicatriz/etiologia , Cicatriz/cirurgia , Contratura/etiologia , Contratura/cirurgia , Efeitos Psicossociais da Doença , Serviços Médicos de Emergência , Humanos , Incidência , Modalidades de Fisioterapia , Cuidados Pós-Operatórios , Fatores de Risco
9.
Facial Plast Surg Clin North Am ; 27(4): 513-517, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31587770

RESUMO

An ideal scar is flat, thin, and color matched to the surrounding skin. Incision planning, skin closure, and postoperative care are vital to create an inconspicuous scar. Depressed, hypertrophic, and keloid scars each pose unique challenges to the facial plastic surgeon. Several surgical and nonsurgical options exist in the treatment of scars. Appropriate treatment is based on scar location, quality, and size as well as patient history, preferences, and expectations. This article discusses techniques for prevention and treatment options for unsightly and hypertrophic scars.


Assuntos
Cicatriz/terapia , Ferida Cirúrgica/complicações , Cicatrização , Cicatriz/etiologia , Cicatriz/prevenção & controle , Humanos , Ferida Cirúrgica/terapia , Técnicas de Fechamento de Ferimentos
10.
Facial Plast Surg Clin North Am ; 27(4): 519-527, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31587771

RESUMO

Complications of rhytidectomy are well known, yet often preventable. A thorough preoperative history and physical along with realistic patient expectations provide the surgeon and patient with insight into potential complications and postoperative management. Understanding of surgical pitfalls and avoidance are crucial in beginning to manage facelift complications. Possible complications of facelift techniques should not discourage surgeons from pursuing a particular technique as the majority of complications are temporary. Though, a strong patient-physician relationship is critical when complications occur. Complications may be frustrating for both the patient and surgeon, yet are overwhelmingly temporary and manageable without surgical intervention.


Assuntos
Hematoma/etiologia , Complicações Pós-Operatórias/etiologia , Ritidoplastia/efeitos adversos , Dermatopatias/etiologia , Retalhos Cirúrgicos/patologia , Anestesia Local/efeitos adversos , Cicatriz/etiologia , Deformidades Adquiridas da Orelha/etiologia , Estética , Traumatismos do Nervo Facial/etiologia , Humanos , Necrose/etiologia , Período Pré-Operatório
11.
Facial Plast Surg Clin North Am ; 27(4): 529-555, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31587772

RESUMO

This article provides facial plastic surgeons with the insight to avoid and address common pitfalls in neck procedures. Many aesthetic issues are created from overtreatment or undertreatment of components of the neck. Using the platysma muscle as the divide, ease of access to superficial anatomy leads to overtreatment problems, whereas difficulty of access to deeper structures leads to undertreatment problems and to overall imbalances. Strategies to accurately assess and treat all structures of the neck proportionally can be used to both avoid and treat any neck aesthetic issues. The advent of minimally invasive techniques has resulted in new complications.


Assuntos
Cervicoplastia/efeitos adversos , Hematoma/etiologia , Pescoço/cirurgia , Complicações Pós-Operatórias/etiologia , Ritidoplastia/efeitos adversos , Cicatriz/etiologia , Deformidades Adquiridas da Orelha/etiologia , Humanos , Miotomia/efeitos adversos , Pescoço/anatomia & histologia , Complicações Pós-Operatórias/prevenção & controle , Complicações Pós-Operatórias/terapia , Recidiva , Seroma/etiologia , Envelhecimento da Pele , Sistema Musculoaponeurótico Superficial/cirurgia
12.
Zhonghua Shao Shang Za Zhi ; 35(10): 712-714, 2019 Oct 20.
Artigo em Chinês | MEDLINE | ID: mdl-31658540

RESUMO

Children are a special group, which have unique physiological characteristics and are still in the period of physical and mental growth and development, thus the prevention and treatment of scar in children are different from that in adults. Scar management in children is a complex and multifaceted system engineering. The grade of scar in children needs to be adjusted according to the age, period, and severity. Corresponding method needs to be chosen for the treatment of scar in children according to the classification of the scar. The compliance of children is poor, and the key to scar treatment is the persistence and cooperation of the parents, so doctors should strengthen propaganda and education to the parents of children with scar. For children with scar, individualized and comprehensive treatment should be used according to the characteristics of children to achieve good results.


Assuntos
Queimaduras/terapia , Cicatriz/reabilitação , Adulto , Queimaduras/complicações , Criança , Cicatriz/etiologia , Humanos , Pais , Pediatria
13.
Cir Cir ; 87(S1): 8-16, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31501623

RESUMO

Background: Procedures to remove adiposities and skin, such as dermolipectomy, can develop wounds that are difficult to heal by conventional therapies. Mesenchymal stem cells are indicated as potential candidates for regenerative therapy in wounds, due to their multipotentiality, low immunogenicity, modulating capacity of inflammation and tissue modeling processes. Case report: Patient with dehiscent chronic ulcer secondary to dermolipectomy, who received cutaneous treatment with mesenchymal stem cells. The therapy induced scar formation and neovascularization, as well as the decrease of infiltrated leukocytes and proinflammatory cytokines. Mesenchymal cells are proposed as an interesting alternative for the treatment of postoperative lesions.


Assuntos
Contorno Corporal/efeitos adversos , Lipectomia/efeitos adversos , Transplante de Células-Tronco Mesenquimais , Medicina Regenerativa/métodos , Úlcera Cutânea/terapia , Deiscência da Ferida Operatória/terapia , Geleia de Wharton/citologia , Adipogenia , Adulto , Antígenos de Superfície/biossíntese , Antígenos de Superfície/genética , Separação Celular , Doença Crônica , Cicatriz/etiologia , Feminino , Expressão Gênica , Humanos , Inflamação , Células-Tronco Mesenquimais , Neovascularização Fisiológica , Osteogênese , Úlcera Cutânea/etiologia , Deiscência da Ferida Operatória/etiologia , Cicatrização
14.
J Ayub Med Coll Abbottabad ; 31(3): 336-339, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31535501

RESUMO

BACKGROUND: Acne effects 80-90% of teenage population all around the world. Resulting scars can lead to facial disfigurement and psychological issues in affected population. To counter this problem many treatment options have been tried including resurfacing lasers, dermabrasion, peeling, fillers, platelet rich plasma therapy etc. All have shown variable results. Among these modalities, micro needling is showing promising results in treatment of acne scars due to collagen induction. This study was conducted to assess efficacy and safety of micro-needling on acne scars. METHODS: In this cross-sectional study a total of 50 patients (female 35, male 15) underwent treatment for post acne scarring, 4 sessions of micro-needling were done under local anaesthesia 3 weeks apart over the span of 2 months. Initial and follow up qualitative assessment was done. Photographs were taken of each patient on their subsequent visit, they were analysed and compared for final results. Grading was done by using Goodman Baron scale. RESULTS: 70% (35) were females and 30% (15) were males with mean age of 27.31±4.41 ranging from 19-35 years. After the treatment of scars, 73% (08) of Grade 4 scars have showed improvement by 2 grades, remaining 27% (03) showed improvement to Grade 3. In 20 patients with Grade 3 scars, 30% (06) showed improvement by 1 grade. Remaining 70% (14) improved by 2 grades. All patients with Grade 2 scar downgraded to grade 1 after treatment. Chi-square test was used to assess pre-treatment and post treatment grading improvement among subjects and was statistically significant. (X2=30.010 p=000).. CONCLUSIONS: Micro needling is an effective tool for aesthetic improvement of post acne scarring.


Assuntos
Acne Vulgar/complicações , Cicatriz , Técnicas Cosméticas , Agulhas , Adulto , Cicatriz/etiologia , Cicatriz/terapia , Estudos Transversais , Feminino , Humanos , Masculino , Adulto Jovem
15.
J Forensic Leg Med ; 68: 101861, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31493722

RESUMO

INTRODUCTION: The evaluation of medico-legal post-traumatic events has been increasing over the last decades. This study analysed the input of dental evaluation in orofacial damage assessment, highlighting the individual's biopsychosocial model, by a serial case study. It is aimed to analyse the physical as well as the psychological repercussions of traumatic events. It also aimed to relate the type of trauma impact with the individual's sequelae. MATERIAL AND METHOD: An observational and retrospective study was carried out of Portuguese medico-legal database. A serial case study was distinguished by the direction of the impact: frontal striking, lateral striking and clashing with a bidirectional (frontal-lateral). RESULTS AND DISCUSSION: 7 cases fulfilled the inclusion criteria, as a pilot study. They have in common the involvement of the 2 lower thirds of the face, including the temporomandibular joint. The consolidation of the maxillary bone fractures does not always correspond to restituto ad integrum. CONCLUSION: The impact direction may guide clinical examination in detecting permanent impairment, emphasizing temporomandibular joint disorders, as well as their association with psychosocial repercussions. The medical-dental examination is differentiating and relevant to the accomplishment of the general objective of damage assessment.


Assuntos
Traumatismos Faciais/complicações , Traumatismos Dentários/complicações , Adolescente , Criança , Cicatriz/etiologia , Restauração Dentária Permanente , Traumatismos Faciais/psicologia , Traumatismos Faciais/terapia , Feminino , Humanos , Masculino , Má Oclusão/etiologia , Maxila/lesões , Pessoa de Meia-Idade , Projetos Piloto , Estudos Retrospectivos , Transtornos da Articulação Temporomandibular/etiologia , Traumatismos Dentários/psicologia , Traumatismos Dentários/terapia , Perda de Dente/etiologia , Adulto Jovem
16.
Transplant Proc ; 51(7): 2215-2220, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31474288

RESUMO

PURPOSE: Hand-assisted retroperitoneoscopic (HARP) donor nephrectomy prevents major complications, but incision site complications may be more frequent in hand-assisted approach. We evaluated long-term incisional complication rates and cosmetic outcomes after HARP donor nephrectomy in our series. MATERIALS AND METHODS: A total of 609 donors who underwent nephrectomy between February 2009 and June 2016 were invited for physical examination and face-to-face interview. A total of 209 donors (35.3%) participated to the study. Sex, age, body mass index (BMI), mean follow-up period, incision-related outcomes of cosmesis, and postoperative complications were evaluated. Body image scale (BIS) and cosmetic scale (CS) (scar test) questionnaires were applied. Higher cosmesis and body image scores indicated greater satisfaction. RESULTS: A total of 191 donors had paramedian (91.4%), and 18 donors had Pfannenstiel incision (8.6%); 121 donors were female (57.9%). The donor mean age and BMI were 49.1 (SD, 1.8) years and 29.7 (SD, 5.1), respectively. Body mass index was significantly lower in the Pfannenstiel group (P < .001). The mean BIS score was 18.9 (SD, 1.8), and the CS questionnaire score was 19.3 (SD, 4,7). The BIS score was significantly better in donors with Pfannenstiel incisions (P < .001), but there was no statistical significance in CS score. The total rate of wound infection was 4.8%, and rate of incisional hernia was 4.8%. The rate of incisional hernia was more frequent in donors with paramedian incision (5.2%), but there was no statistical significance. Six donors (2.9%) required rehospitalization because of incision site complications. CONCLUSION: Hand-assisted retroperitoneoscopic donor nephrectomy avoids intra-abdominal complications, but rate of incision site complications can be higher in hand-assisted procedure. The donors were convinced from the cosmetic outcome after HARP donor nephrectomy. The ones who had Pfannenstiel incision had better satisfaction according to BIS score.


Assuntos
Hérnia Incisional/etiologia , Doadores Vivos , Nefrectomia/efeitos adversos , Complicações Pós-Operatórias/etiologia , Coleta de Tecidos e Órgãos/efeitos adversos , Adulto , Idoso , Índice de Massa Corporal , Cicatriz/etiologia , Feminino , Humanos , Transplante de Rim , Masculino , Pessoa de Meia-Idade , Nefrectomia/métodos , Fatores de Risco , Coleta de Tecidos e Órgãos/métodos
17.
Medicina (B Aires) ; 79(4): 299-302, 2019.
Artigo em Espanhol | MEDLINE | ID: mdl-31487253

RESUMO

Cicatrizing conjunctivitis is the final consequence of several diseases. The most severe among them are cicatricial pemphigoid and chronic Stevens-Johnson syndrome. Systemic immunosuppressive drugs and steroids are usually an effective approach to these diseases. However, a few patients follow a recalcitrant course unremitting to usual therapy. We describe the treatment with rituximab of seven patients with cicatricial pemphigoid and two with chronic Stevens-Johnson syndrome. Eight of them also received gammaglobulin and all achieved clinical remission. Three relapsed and required two or three new courses of rituximab with good control of disease activity. Rituximab proved to be an efficacious drug for chronic recalcitrant cicatrizing conjunctivitis.


Assuntos
Cicatriz/tratamento farmacológico , Conjuntivite/tratamento farmacológico , Fatores Imunológicos/administração & dosagem , Penfigoide Mucomembranoso Benigno/complicações , Rituximab/administração & dosagem , Síndrome de Stevens-Johnson/complicações , Adulto , Idoso , Doença Crônica , Cicatriz/etiologia , Conjuntivite/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
18.
Cutis ; 104(1): 57-61, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31487338

RESUMO

Persistent adult acne is one of the most difficult types of acne to treat. It is a long-lasting disease with uncontrolled exacerbations that often result in scarring. The aim of this study was to analyze the influence of acne therapy used in adolescence on patients who later developed persistent adult acne. The use of oral antibiotics, isotretinoin, and topical retinoids in adolescence and their role in diminishing scar formation during adult acne was analyzed. This population-based study included 111 patients, 91 of whom had persistent adult acne. Results indicated that the use of isotretinoin or topical retinoids for adolescent acne decreased the risk for scar occurrence in adulthood.


Assuntos
Acne Vulgar/tratamento farmacológico , Cicatriz/epidemiologia , Fármacos Dermatológicos/administração & dosagem , Acne Vulgar/complicações , Administração Cutânea , Administração Oral , Adolescente , Adulto , Antibacterianos/administração & dosagem , Cicatriz/etiologia , Feminino , Humanos , Isotretinoína/administração & dosagem , Masculino , Retinoides/administração & dosagem
19.
Skinmed ; 17(3): 207-209, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31496480

RESUMO

A 24-year-old man (Figure 1) and a 22-year-old woman (Figure 2) with atrophic acne scars were enrolled. Each patient underwent four sessions of treatment with intervals of 4 weeks consecutively, each consisting of microneedling followed by platelet-rich plasma (PRP) application on the right side of the face and microneedling alone on the left. Goodman's qualitative scale was used for the final evaluation of the results. The man had grade 4 acne scars on both sides of the face, which became grade 2 on the right side and grade 3 on the left side (Figure 3). The woman had grade 4 acne scars on both sides of the face, which diminished to grade 1 on the right side and grade 2 on the left side (Figure 4). Improvements were observed after the third treatment.


Assuntos
Cicatriz/patologia , Cicatriz/terapia , Técnicas Cosméticas , Plasma Rico em Plaquetas , Pele/patologia , Acne Vulgar/complicações , Atrofia/etiologia , Atrofia/terapia , Cicatriz/etiologia , Terapia Combinada , Feminino , Humanos , Masculino , Agulhas , Índice de Gravidade de Doença , Adulto Jovem
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