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1.
Food Chem ; 403: 134362, 2023 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-36183464

RESUMO

Thigh meat from Cobb 500 broiler (Cobb) and Beijing-You chicken (BYC) at marketable age were compared to explore the impact of growth rate on meat quality. BYC had a higher water capacity, as well as lower shear forces and IMF content than Cobb, indicating that the growth rate has a significant influence on meat quality. Additionally, 144 upregulated and 44 downregulated differential metabolites were identified using gas chromatography mass spectroscopy (GC-MS) and liquid chromatography mass spectrometer (LC-MS). Moreover, we found a significant difference between the dominant expression of metabolites in the two genotypes. The highly expressed metabolites in Cobb were amino acids and their derivatives, including l-citrulline, dimethylglycine, 1,4-butanediamine, alanine, and creatine. In contrast, BYC deposited more bioactive compounds, such as, α-linolenic acid, linoleic acid, eicosapentaenoic acid, anserine, and taurine. These results indicate that meat quality and metabolite profiles differ greatly between fast- and slow-growing chickens.


Assuntos
Ração Animal , Galinhas , Animais , Galinhas/genética , Ração Animal/análise , Cromatografia Gasosa-Espectrometria de Massas , Coxa da Perna , Cromatografia Líquida , Espectrometria de Massas em Tandem , Carne/análise
3.
Sci Rep ; 12(1): 19606, 2022 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-36380116

RESUMO

The neutropenic thigh infection model is one of the standard models in pharmacokinetic/ pharmacodynamic (PK/PD) characterization of novel antibacterials which are urgently needed due to the rise of antimicrobial resistance. The model enables to investigate PK/PD parameters crucial for translation of animal results towards humans. However, the neutropenic thigh infection model can result in moderate to severe discomfort of the animals, especially when high inocula are used. Tramadol has been proven to reduce pain effectively. This study investigates if tramadol influences the bacterial burden in the primary organ, the thighs, and organs affected by secondary seeding. Therefore, several strains of the ESKAPE pathogens, namely S. aureus, P. aeruginosa, K. pneumoniae, E. coli, A. baumannii and E. faecalis were examined. It was shown that tramadol did not influence the bacterial burden neither in thighs nor in organs affected by secondary seeding for the strains of E. faecalis, S. aureus, P. aeruginosa, K. pneumoniae and E.coli tested here, whereas secondary seeding seemed to be affected by tramadol for the tested strain of A. baumannii. Consequently, it was demonstrated that tramadol is an option to reduce discomfort in the untreated group for the strains of five out of the six tested ESKAPE pathogens and, thereby, contributes to the refinement of one of the standard PK/PD models.


Assuntos
Neutropenia , Tramadol , Humanos , Animais , Coxa da Perna/microbiologia , Staphylococcus aureus , Testes de Sensibilidade Microbiana , Tramadol/farmacologia , Escherichia coli , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Bactérias , Klebsiella pneumoniae , Neutropenia/tratamento farmacológico , Pseudomonas aeruginosa
4.
Sci Rep ; 12(1): 18540, 2022 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-36329237

RESUMO

The obturator internus, gemelli, and quadratus femoris muscles are thought to be postural muscles. Thus, they are in the focus of research. Although these muscles are described in other species, detailed descriptions are still lacking for the albino rat. We hypothesized that the rat's ischiotrochanteric muscle group is comparable to that of humans. We aimed to provide a detailed description, and to compare the rat's condition with other species including humans. Both hind limbs of 30 adult male formalin-fixed albino rats were carefully dissected and photo documented. Our results were then compared with data for other species and descriptions of human anatomy. The gemellus muscle was one single muscle mass, originating from the lesser sciatic notch and an unnamed groove on the dorsal aspect of the ischium. The obturator internus muscle arose from the inner aspect of the tabula of ischium. Both muscles formed a continuum and inserted as one complex on the medial aspect of the greater trochanter. The quadratus femoris muscle originated from the outer aspect of the tabula of ischium and inserted on the distal portion of the intertrochanteric crest, and the dorsal aspect of the lesser trochanter. Despite minor differences, the topographical conditions of these muscles are comparable between rats and other mammals including humans.


Assuntos
Quadril , Coxa da Perna , Adulto , Animais , Masculino , Humanos , Ratos , Músculo Esquelético/fisiologia , Ísquio , Fêmur , Mamíferos
5.
Zhongguo Dang Dai Er Ke Za Zhi ; 24(11): 1231-1237, 2022 Nov 15.
Artigo em Chinês | MEDLINE | ID: mdl-36398549

RESUMO

OBJECTIVES: To summarize the skeletal muscle magnetic resonance imaging (MRI) features of the lower limbs in common subtypes of muscular dystrophy (MD) and the experience in the application of MRI in the diagnosis of MD. METHODS: A total of 48 children with MD who were diagnosed by genetic testing were enrolled as subjects. The muscle MRI features of the lower limbs were analyzed. Cumulative fatty infiltration score was calculated for each subtype, and the correlation of cumulative fatty infiltration score with clinical indices was analyzed for Duchenne muscular dystrophy (DMD). RESULTS: DMD was characterized by the involvement of the gluteus maximus and the adductor magnus. Becker muscular dystrophy was characterized by the involvement of the vastus lateralis muscle. Limb-girdle muscular dystrophy was characterized by the involvement of the adductor magnus, the vastus intermedius, the vastus medialis, and the vastus lateralis muscle. For DMD, the cumulative fatty infiltration score of the lower limb muscles was significantly correlated with age, course of the disease, muscle strength, and motor function (P<0.05), while it was not significantly correlated with the serum creatine kinase level (P>0.05). CONCLUSIONS: Different subtypes of MD have different MRI manifestations, and MRI may help with the diagnosis and assessment of MD.


Assuntos
Distrofia Muscular do Cíngulo dos Membros , Distrofia Muscular de Duchenne , Criança , Humanos , Distrofia Muscular de Duchenne/diagnóstico por imagem , Distrofia Muscular do Cíngulo dos Membros/diagnóstico por imagem , Distrofia Muscular do Cíngulo dos Membros/patologia , Músculo Esquelético/diagnóstico por imagem , Imageamento por Ressonância Magnética/métodos , Coxa da Perna/patologia
6.
Jt Dis Relat Surg ; 33(3): 673-679, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36345197

RESUMO

Combined tendocutaneous defect of Achilles tendon remains a complex reconstructive challenge whereby both the soft tissue coverage and tendon reconstruction have to be considered to achieve a good functional and aesthetic outcome. A 14-year-old boy who sustained an open right calcaneum fracture (Gustilo-Anderson IIIB) with a transected Achilles tendon and huge skin defect from motorcycle wheel spoke injury was admitted. The Achilles tendon repair site broke down following initial surgical debridement and primary repair, resulting in a sizeable combined tendocutaneous defect. Simultaneous soft tissue coverage and tendon defect reconstruction using composite sensate free anterior lateral thigh (ALT) fasciocutaneous flap with vascularized fascia lata was performed subsequently. The vascularized fascia lata was tubularized to wrap the native proximal stump of Achilles tendon and secured using the modified Krakow suturing technique. The distal end of tubularized fascia lata was, then, secured by drilling across right calcaneum bone, passing the suture transosseously and screwed. He led an uneventful postoperative recovery with satisfactory functional and aesthetic outcomes at one year of follow-up. In conclusion, the present case demonstrates the reliability of this technique and its advantages over other flap choices in reconstruction of a huge combined tendocutaneous defect.


Assuntos
Tendão do Calcâneo , Retalhos de Tecido Biológico , Lesões dos Tecidos Moles , Masculino , Humanos , Adolescente , Fascia Lata/lesões , Fascia Lata/transplante , Coxa da Perna/cirurgia , Coxa da Perna/lesões , Tendão do Calcâneo/cirurgia , Tendão do Calcâneo/lesões , Lesões dos Tecidos Moles/cirurgia , Reprodutibilidade dos Testes
7.
J Wound Ostomy Continence Nurs ; 49(6): 518-521, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36417373

RESUMO

PURPOSE: The prevalence of friction skin injury (FcI) in an acute care hospital was evaluated as part of a quality improvement initiative. PARTICIPANTS/SETTING: The setting for this quality improvement project was an academic medical center with 728 licensed beds in the central plains of the United States. Data were collected by 33 clinicians: 28 were RN staff members and 5 were patient care technicians. Six of the 28 nurses (21%) were board-certified wound nurses and 2 (7%) were in training but not yet certified. Prevalence data were collected on 354 hospitalized patients. APPROACH: Friction skin injuries were measured in conjunction with the institution's quarterly skin survey for the NDNQI PUPS (National Database of Nursing Quality Indicators Pressure Ulcer Prevalence Survey) in August 2019. The prevalence of FcI was calculated using the number of patients with FcI divided by the total number of patients surveyed. OUTCOMES: Three hundred fifty-four patients completed the survey in this PUPS; FcI was diagnosed in 8 patients, yielding a prevalence rate of 2.3%. Clinical manifestations of FcI such as lichenification, skin/soft tissue discoloration, skin/soft tissue deformation and/or callus formation, and skin ulceration were also documented. In addition, a majority of patients with FcI were found to have fecal or urinary incontinence (n = 5/8, 63%; 2 had both fecal and urinary incontinence, 25%). Braden Scale for Pressure Sore Risk subscales scores were analyzed; the mean subscale score for moisture was 3.4; the mean subscale score for friction/shear was 1.4; the mean subscale score for activity was 2.6; and the mean subscale score for mobility was 2.9. IMPLICATIONS FOR PRACTICE: To the best of my knowledge, this is the first published article documenting FcI prevalence in any care setting. Additional prevalence studies are needed to establish the epidemiology of FcI across care settings and in the community.


Assuntos
Úlcera Cutânea , Incontinência Urinária , Humanos , Estados Unidos , Prevalência , Nádegas , Fricção , Coxa da Perna , Melhoria de Qualidade , Incontinência Urinária/epidemiologia
8.
Zhonghua Wai Ke Za Zhi ; 60(11): 1011-1017, 2022 Nov 01.
Artigo em Chinês | MEDLINE | ID: mdl-36323584

RESUMO

Objective: To investigate the method and effect of free anterolateral thigh myocutaneous flap combined with pedicled latissimus dorsi myocutaneous flap transfer for functional reconstruction after resection of huge shoulder tumor. Methods: The clinical data of 6 patients who were treated with pedicled latissimus dorsi myocutaneous flap combined with free anterolateral thigh myocutaneous flap to repair large-area complex defects after shoulder tumor resection at Department of Oncology Plastic Surgery, Hunan Province Cancer Hospital from December 2015 to December 2020 were retrospectively analyzed. There were 2 males and 4 females, with an average age of 41.7 years (range:29 to 56 years). There were 2 cases of synovial sarcoma,2 cases of phylloid cell sarcoma,1 case of liposarcoma and 1 case of fibrosarcoma. Before this operation, tumor resection had been performed for 1 to 5 times on each case,and the course of disease was 6 to 24 months. Pedicled latissimus dorsi myocutaneous flap combined with free anterolateral thigh myocutaneous flap were used to repair soft tissue defects and reconstruct deltoid function. Postoperative flap status, complications, appearance and function of upper limbs and tumor recurrence were recorded. Results: Six patients were followed up for an average of 21.6 months (range: 12 to 36 months). There were no serious complications after operation,and all flaps survived. No tumor recurrence was found. The appearance of shoulder contour reconstructed by flaps was satisfactory. The reinnervation effect of lateral femoral muscle was confirmed recovered smoothly by neuroelectromyography 3 months after operation. Shoulder function was mildly limited in 3 patients,moderately limited in 2 patients and severely limited in 1 patient. All patients reported significant improvement in shoulder discomfort.The overall functional results of all patients were satisfactory. Conclusion: Combined myocutaneous flaps transplantation can perfectly repair the wound left after the resection of huge shoulder tumor,minimize the recurrence of tumor,reconstruct the function of shoulder joint and greatly improve the quality of life of patients.


Assuntos
Mamoplastia , Retalho Miocutâneo , Procedimentos Cirúrgicos Reconstrutivos , Sarcoma , Lesões dos Tecidos Moles , Músculos Superficiais do Dorso , Masculino , Feminino , Humanos , Adulto , Coxa da Perna , Ombro , Qualidade de Vida , Estudos Retrospectivos , Transplante de Pele , Procedimentos Cirúrgicos Reconstrutivos/métodos , Extremidade Superior , Resultado do Tratamento
9.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi ; 57(10): 1225-1229, 2022 Oct 07.
Artigo em Chinês | MEDLINE | ID: mdl-36319129

RESUMO

Objective: To investigate the efficacy of anterolateral thigh flap preforming tongue in patients with total glossectomy. Methods: A total of 27 patients with tongue cancer who underwent total glossectomy, neck lymph node dissection and anterolateral thigh flap transfer were collected from January 2019 to April 2021 in the Department of Oral and Maxillofacial Surgery at the Second Xiangya Hospital. All patients were males, the age ranged from 35-73 years. The patients were divided into experimental (14 cases) and control (13 cases) groups, based on whether the tongue was reconstructed. The clinical parameters of two groups were analyzed by independent sample t test or Fisher exact probability method. Results: The success rate of free flap was 100%, of the patients, 2 patients had cervical hematoma and 1 patient had wound infection postoperatively. There was no difference in speech (6.69±3.42 vs. 5.50±3.01, t=0.96, P=0.346) or swallowing (χ2=0.46, P=0.793) function between two groups at 1 month after surgery. However, the speech (24.94±7.43 vs. 18.44±6.30, t=2.48, P=0.020) and swallowing (χ2=6.97, P=0.008) functions in experimental group were significantly better than those in control group. No case was lost to follow-up. All patients were extubated after operation, with average time of 7.2 days in the experimental group and 7.7 days in the control group. The overall survival rate was 71.4% in the experimental group and 61.5% in the control group. Conclusion: The use of anterolateral thigh flap preforming tongue can improve the speech and swallowing functions in patients with total glossectomy and offer a novel method for tongue construction.


Assuntos
Retalhos de Tecido Biológico , Neoplasias da Língua , Masculino , Humanos , Adulto , Pessoa de Meia-Idade , Idoso , Feminino , Glossectomia , Coxa da Perna , Língua
10.
Alzheimers Res Ther ; 14(1): 145, 2022 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-36195949

RESUMO

BACKGROUND: The relationship of specific body composition in the thighs and brain amyloid-beta (Aß) deposition remained unclear, although there were growing evidence that higher muscle and fat mass in thighs had a protective effect against cardiometabolic syndromes. To determine whether muscle mass and fat mass in the thighs affected amyloid-beta (Aß) positivity differently in relation to gender, we investigated the association of muscle mass and fat mass with Aß positivity using positron emission tomography (PET) in individuals without dementia. METHODS: We recruited 240 participants (134 [55.8%] males, 106 [44.2%] females) without dementia ≥45 years of age who underwent Aß PET, bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DEXA) scans of the hip in the health promotion center at Samsung Medical Center in Seoul, Korea. Lower extremity skeletal muscle mass index (LASMI) was measured using BIA, and gluteofemoral fat percentage (GFFP) was estimated using DEXA scans of the hip. We investigated the associations of LASMI and GFFP with Aß positivity using logistic regression analyses after controlling for age, APOE4 genotype, and cognitive stage. RESULTS: Higher muscle mass in the thighs, measured as LASMI (odds ratio [OR]=0.27, 95% confidence interval [CI] 0.08 to 0.84, p=0.031) was associated with a lesser risk of Aß positivity in only females. Higher fat mass in the thighs, measured as GFFP (OR=0.84, 95% CI 0.73 to 0.95, p=0.008) was associated with a lesser risk of Aß positivity in only males. However, the association between LAMSI (p for interaction= 0.810), GFFP (p for interaction= 0.075) and Aß positivity did not significantly differ by gender. Furthermore, LAMSI only negatively correlated with centiloid (CL) values in females (r=-0.205, p=0.037), and GFFP only negatively correlated with CL values only in males (r=-0.253, p=0.004). CONCLUSIONS: Our findings highlight the importance of recognizing that gender differences exist with respect to the specific body composition to potentially protect against Aß deposition. Therefore, our results may help in designing gender-specific strategies for controlling body composition to prevent Aß deposition.


Assuntos
Apolipoproteína E4 , Demência , Peptídeos beta-Amiloides/metabolismo , Apolipoproteína E4/genética , Encéfalo/diagnóstico por imagem , Encéfalo/metabolismo , Feminino , Humanos , Masculino , Músculo Esquelético/diagnóstico por imagem , Músculo Esquelético/metabolismo , Tomografia por Emissão de Pósitrons , Coxa da Perna/diagnóstico por imagem
11.
Med Eng Phys ; 108: 103889, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-36195360

RESUMO

The main objective of this study was to determine which muscle force reduction, among the vastus muscles (VAS), rectus femoris (RF), gluteus medius (Gmed), and gluteus maximus (Gmax) most significantly influenced the knee contact force. Ten young adults walked at a comfortable speed. The medial and lateral knee contact forces (KCFmed and KCFlat) were computed by a musculoskeletal model with full-force-generating capacity and four muscle inactivation models that separately constrained the forces of Gmed, Gmax, VAS, and RF. Additionally, we evaluated compensatory alterations in muscle forces caused by the reduction of each muscle activity. Reduction in Gmed force induced an increase in KCFmed and a decrease in KCFlat through the stance phase, along with compensatory increase in VAS and Gmax forces in the early stance phase and RF and Gmax forces in the late stance phase. Conversely, when the RF force was constrained, decreases in KCFmed and KCFlat and compensatory increases in VAS and Gmed were observed in the late stance phase. Our results indicated that Gmed and RF most significantly influence the knee contact force during walking.


Assuntos
Articulação do Joelho , Caminhada , Fenômenos Biomecânicos , Eletromiografia , Marcha/fisiologia , Humanos , Articulação do Joelho/fisiologia , Extremidade Inferior , Músculo Esquelético/fisiologia , Coxa da Perna , Caminhada/fisiologia , Adulto Jovem
12.
Sci Rep ; 12(1): 16762, 2022 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-36202885

RESUMO

The aim of this study was to investigate the physiological effects of compression tights on blood flow following exercise and to assess if the placebo effect is responsible for any acute performance or psychological benefits. Twenty-two resistance-trained participants completed a lower-body resistance exercise session followed by a 4 h recovery period. Participants were assigned a post-exercise recovery intervention of either compression tights applied for 4 h (COMP), placebo tablet consumed every hour for 4 h (PLA) or control (CON). Physiological (markers of venous return, muscle blood flow, blood metabolites, thigh girth), performance (countermovement jump, isometric mid-thigh pull), and psychological measures (perceived muscle soreness, total quality of recovery) were collected pre-exercise, immediately post-exercise, at 30 (markers of venous return and muscle blood flow) and 60 min (blood metabolites, thigh girth and psychological measures) intervals during 4 h of recovery, and at 4 h, 24 h and 48 h post-exercise. No significant (P > 0.05) differences were observed between interventions. However, effect size analysis revealed COMP enhanced markers of venous return, muscle blood flow, recovery of performance measures, psychological measures and reduced thigh girth compared to PLA and CON. There were no group differences in blood metabolites. These findings suggest compression tights worn after resistance exercise enhance blood flow and indices of exercise recovery, and that these benefits were not due to a placebo effect.


Assuntos
Mialgia , Efeito Placebo , Exercício Físico/fisiologia , Humanos , Músculo Esquelético/fisiologia , Poliésteres , Coxa da Perna
13.
Zhonghua Nei Ke Za Zhi ; 61(10): 1144-1151, 2022 Oct 01.
Artigo em Chinês | MEDLINE | ID: mdl-36207969

RESUMO

Objective: To summarize the clinical, thigh magnetic resonance (tMRI) and electromyographic (EMG) characteristics in patients with immune-mediated necrotizing myopathy (IMNM). Methods: A total of 32 IMNM patients who were admitted to the Department of Neurology from April 2019 to April 2021 were enrolled at the First Medical Centre of Chinese PLA General Hospital. According to the type of antibody, the patients were divided into anti-SRP antibody positive (SRP+) group, anti-HMGCR antibody positive (HMGCR+) group and seronegative (SN) group. The gender, age, course of disease, myositis antibodies, extramuscular manifestations, EMG were collected and analyzed among three groups. The characteristics of skeletal muscle were assessed by tMRI inflammatory edema and fat infiltration scores. Analysis of variance, Kruskal-Wallis test and Chi-square test were used to compare the differences in different clinical characteristics and tMRI scores among the three groups. When there was a statistical difference among the three groups, the comparison between the two groups was corrected by the Bonferroni method. Result: (1) Of the 32 patients, 20 were females (62.5%).The median age of onset was 47±14 years, 25 (78.1%) patients had an acute or subacute course.There were 17 (53.1%) with SRP+, 8 (25.0%) with HMGCR+, and 7 (21.9%) with MSAs (myositis specific antibodies) negative. Anti-Ro52 antibody was the most common combined antibody (12/32, 37.5%), among which 10 were in SRP+group.(2) The CK of all patients were elevated, median was 5 948 (4 229, 7 664) U/L. There was no statistical difference of MMT scores among three groups. The proximal limb score was lower than distal limb (P<0.01). The axial muscle score was lower than the distal limb score (P<0.05).(3) Extramuscular manifestations of HMGCR+ group were lower than those of the other two groups (12.5% vs. 71.4% and 76.5%, P<0.017). Rash (60.0% vs.14.3%, P<0.05) and interstitial pulmonary diseases (70.0% vs. 14.3%, P<0.05) were more common in patients with anti-SRP coexistence with anti-Ro52 than those with isolated anti-SRP. Connective tissue disease was more common in SN group (57.1% vs. 11.8% and 0, P<0.017).(4) tMRI showed fascial edema of SN group was more obvious than that of the other two groups (P<0.017). There was no statistical difference in the degree of fat infiltration and inflammatory edema among three groups, but SRP+ group had more cases of early fat infiltration.(5) Myotonic potentials (25.0% vs. 0 and 0, P<0.017) and compound repetitive discharges (CRDs) (50.0% vs. 5.9% and 0, P<0.017) were common in HMGCR+ group. Proteomic analysis found significantly different expressed proteins in skeletal muscle of patients with myotonic potentials or CRDs were associated with cytoskeleton, cell junction and extracellular matrix. Conclusion: IMNM with pure anti-SRP antibody positive and anti-HMGCR positive were mainly affected by skeletal muscles. Those who were co-positive for anti-SRP antibody and anti-Ro52 antibody had more extramuscular manifestations, which might be a special subtype of SRP+ group. This study proposed for the first time that myofascial inflammatory edema is an early sign of SN-IMNM injury. EMG of HMGCR+group were more prone to myotonia potential and CRDs.


Assuntos
Doenças Autoimunes , Doenças Musculares , Miosite , Adulto , Anticorpos , Autoanticorpos , Doenças Autoimunes/complicações , Edema , Eletrofisiologia , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/patologia , Doenças Musculares/diagnóstico , Miosite/patologia , Necrose/patologia , Poliésteres , Proteômica , Estudos Retrospectivos , Coxa da Perna/patologia
15.
Anaesthesiologie ; 71(11): 858-864, 2022 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-36282281

RESUMO

Meralgia paraesthetica (MP) is the consequence of an entrapment or stretch injury of the lateral femoral cutaneous nerve at the crossing region with the inguinal ligament where the nerve exits the pelvis. It results in temporary or permanent sensory loss, paraesthesia and pain in the anterolateral region of the thigh. Idiopathic forms are known for example as seat belt syndrome or jeans syndrome. An MP can also occur as a complication of surgical or intensive care patient positioning. In focus are the lithotomy position, prone position and beach chair position.We analyzed 21 complaints about MP occurring for the first time postoperatively, which had been submitted to the expert committee for medical treatment errors at the North Rhine Medical Association over the past 10 years. Among these, six cases could be identified as positioning damage after a lithotomy position. In three cases MP occurred after supine positioning but the etiology could not be clarified with certainty. In 12 cases MP was recognized as a direct surgical complication.The pathophysiology, incidence and course as well as legal implications of position-related MP are discussed. Pressure damage to the nerve at its intersection with the inguinal ligament is assumed to be the main pathomechanism. Although all the cases presented here occurred after lithotomy positioning, the complication also appears to occur with other types of positioning according to the literature data, the most common being prone positioning. This also explains the increasingly published case reports of MP after prone positioning in COVID-19 patients for respiratory treatment. Safe avoidance of the positioning-related complication does not appear to be possible due to the anatomical variability of the course of the nerve and the unclear pathomechanisms.


Assuntos
COVID-19 , Neuropatia Femoral , Síndromes de Compressão Nervosa , Humanos , Neuropatia Femoral/etiologia , Síndromes de Compressão Nervosa/etiologia , Coxa da Perna/inervação , Posicionamento do Paciente/efeitos adversos
18.
Tomography ; 8(5): 2498-2507, 2022 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-36287807

RESUMO

Although most of the adverse events derived from dry needling are minor, avoiding potential hazards for patients including accidental invasion of vessels, ganglia, and nerves is essential to ensure patients' safety. We aimed to investigate the contribution of predictors explaining the variance of sartorius muscle depth limit at proximal third and middle thigh as these locations lead to an augmented risk of neurovascular bundle invasion during dry needling application. A diagnostic study was conducted on 84 subjects to calculate the accuracy of a prediction model for sartorius depth, as assessed with ultrasound imaging, based on sex, age, height, weight, body mass index (BMI), thigh perimeter, and length. After calculating a correlation matrix, a multiple linear regression analysis was performed to detect those variables contributing to the sartorius deep limit in both locations. Although males showed greater thigh perimeter than women (p &lt; 0.001), the deep limit of the sartorius muscle was significantly more superficial for both the proximal third (p = 0.003) and the mid-third (p = 0.004) points. No side-to-side anthropometric differences were found (p &gt; 0.05). In addition, we found sartorius muscle depth to be associated with the proximal and mid-third girth, gender, height, and BMI (all, p &lt; 0.01). Gender, proximal-third girth, and BMI explained 51.1% and 42.6% of the variance for the sartorius deep limit at the proximal and the mid-third, respectively. This study analyzed whether anthropometric features could predict sartorius muscle depth in healthy participants for assisting clinicians in choosing the optimal needle length to avoid accidental femoral bundle puncture.


Assuntos
Agulhamento Seco , Coxa da Perna , Masculino , Humanos , Feminino , Coxa da Perna/diagnóstico por imagem , Músculo Esquelético/diagnóstico por imagem , Músculo Esquelético/irrigação sanguínea , Músculo Esquelético/inervação , Artéria Femoral , Punções
19.
Australas J Dermatol ; 63(4): 493-494, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36222445

RESUMO

Streptococcal sex syndrome is a rare and under-recognised association between recurrent pubic, genital or thigh cellulitis, sexual intercourse and pelvic surgery or radiation. Lymphatic dysfunction may play a role in the aetiology of the syndrome. We describe a case of streptococcal sex syndrome and describe suggested management strategies.


Assuntos
Celulite (Flegmão) , Infecções Estreptocócicas , Humanos , Celulite (Flegmão)/complicações , Infecções Estreptocócicas/complicações , Infecções Estreptocócicas/diagnóstico , Coxa da Perna , Coito , Streptococcus , Síndrome
20.
Sci Rep ; 12(1): 16622, 2022 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-36198750

RESUMO

We aimed to derive comprehensive MRI parameters that reflect intramuscular fat infiltration severity for designated lower extremity levels, based on semiquantitative analyses in Charcot-Marie-Tooth disease type 1A (CMT1A) patients. We reviewed lower extremity MRIs of 116 CMT1A patients. Intramuscular fat infiltration grading using the Mercuri scale was performed for the non-dominant lower extremity at three levels (proximal, mid, and distal) for the thigh and at two levels (proximal and distal) for the lower leg. Based on MRI results, the following parameters were calculated for each level and for entire muscles: fat infiltration proportion (FIP), significant fat infiltration proportion (SigFIP), and severe fat infiltration proportion (SevFIP). The relationships between the MRI parameters and clinical data were evaluated using Spearman's correlation analysis. FIP, SigFIP, and SevFIP measured for entire muscles significantly correlated with Charcot-Marie-Tooth Neuropathy Score (p < 0.001), functional disability scale (p < 0.001), 10-m walk test time (p = 0.0003, 0.0010, and 0.0011), and disease duration (p < 0.001). Similar correlations were demonstrated for FIP, SigFIP, and SevFIP acquired from the lower leg. Our MRI parameters obtained through semiquantitative analyses of muscles significantly correlated with clinical parameters in CMT1A patients, suggesting their potential applicability as imaging markers for clinical severity.


Assuntos
Doença de Charcot-Marie-Tooth , Doença de Charcot-Marie-Tooth/patologia , Humanos , Extremidade Inferior , Imageamento por Ressonância Magnética/métodos , Músculos/patologia , Coxa da Perna/patologia
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