Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 53.556
Filtrar
1.
Dermatol Clin ; 40(1): 73-81, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34799037

RESUMO

The understanding of melanocytes is fundamental to the study of dermatology. These dendritic cells underly the most feared primary cutaneous malignancy, fuel escalating progress in immunotherapy strategies, and invariably underlie entire socioeconomic constructs consciously or unconsciously based on skin tone. Various ethno-genotypes combine with increasing frequency over time, increasing the diversity of skin types that may present with dermatologic diagnoses. Understanding the biology of a variety of skin tones and ethnic practices congruent with distribution of skin tone is invaluable to any physician who wishes to practice efficient and expert care, especially to pediatric patients of this category.


Assuntos
Dermatologia , Neoplasias , Dermatopatias , Criança , Grupos Étnicos , Humanos , Pele , Dermatopatias/terapia , Pigmentação da Pele
2.
Dermatol Clin ; 40(1): 83-93, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34799038

RESUMO

Many dermatologic conditions common in the pediatric population may have unique presentations in skin of color or occur with greater incidence. This may be due to ethnic origin, socioeconomic factors, or other influences. Awareness of the potential variations in skin of color may enhance prompt diagnosis, appropriate treatment, and/or reassurance as indicated.


Assuntos
Dermatologia , Dermatopatias , Criança , Grupos Étnicos , Humanos , Pele , Dermatopatias/epidemiologia , Pigmentação da Pele
3.
Dermatol Clin ; 40(1): 95-102, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34799040

RESUMO

Pediatric dermatology is an incredibly rewarding field. Children are resilient and funny and just want to know that you are advocating for their best interests. Teaming up with children and their parents can lead to fantastic therapeutic alliances and success. The author has divided this chapter based on a handful of common pediatric dermatologic diseases and what he sees as some of the main clinical and therapeutic tips and tricks that have helped him in his practice.


Assuntos
Dermatologia , Dermatopatias , Criança , Humanos , Dermatopatias/terapia
4.
Parasitol Int ; 86: 102481, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34688883

RESUMO

Dirofilariasis is an emerging zoonosis caused by nematodes of the genus Dirofilaria, most often D. repens and D. immitis. The main final hosts and reservoirs of pathogens are dogs. The intermediate hosts and vectors of infection are female mosquitoes (Culicidae). Human is an accidental host in which the parasite does not usually mature. Over the past 20 years, the range of Dirofilaria spp. in Europe has expanded. We present an unusual case of multifocal dirofilariasis of mixed subcutaneous-ocular course caused by D. repens in a 52-year-old Polish patient who was probably infected in Spain or Croatia, where she stayed one year before the onset of symptoms. Surgical removal of the nematodes followed by treatment with Ivermectin in a single dose of 1200 µg and Doxycycline 200 mg daily for 7 days resulted in complete recovery. We believe that all cases of human dirofilariasis, especially in countries where the disease is not frequent at present, should be registered for epidemiological purposes. Moreover, due to the widening of the range of D. repens and D. immitis occurrence and the possibility of atypical courses of infection with both nematodes, diagnostics should include the species identification of the parasite.


Assuntos
Dirofilaria repens/isolamento & purificação , Dirofilariose/diagnóstico , Oftalmopatias/diagnóstico , Dermatopatias/diagnóstico , Animais , Antiparasitários/administração & dosagem , Croácia , Dirofilariose/tratamento farmacológico , Dirofilariose/parasitologia , Dirofilariose/cirurgia , Doxiciclina/administração & dosagem , Oftalmopatias/tratamento farmacológico , Oftalmopatias/parasitologia , Oftalmopatias/cirurgia , Feminino , Humanos , Ivermectina/administração & dosagem , Pessoa de Meia-Idade , Polônia , Dermatopatias/tratamento farmacológico , Dermatopatias/parasitologia , Dermatopatias/cirurgia , Espanha , Viagem , Resultado do Tratamento
5.
Rev Med Chil ; 149(5): 747-757, 2021 May.
Artigo em Espanhol | MEDLINE | ID: mdl-34751328

RESUMO

Monoclonal gammopathies of uncertain significance (MGUS) correspond to pre-malignant hematological disorders characterized by the production of a monoclonal protein and infiltration of less than 10% of the bone marrow by plasma cells. Its importance lies in the risk of progression to malignant disorders and in the association with different renal, neurological and skin manifestations. There are pathophysiological mechanisms that support a causal relationship between monoclonal gammopathies (MGs) and different skin diseases, such as type I cryoglobulinemia (CG), primary systemic amyloidosis (PSA) or necrobiotic xanthogranuloma (NXG). However, there is a group of skin diseases associated with MGs whose pathogenesis has not been elucidated. In this context, the role of the dermatologist is crucial in the suspicion of different haematological disorders based on skin manifestations and in the multidisciplinary treatment of these patients. In this article, we carry out an exhaustive review of the literature published in this area and propose a screening algorithm for MGs in patients with specific skin diseases.


Assuntos
Amiloidose de Cadeia Leve de Imunoglobulina , Gamopatia Monoclonal de Significância Indeterminada , Paraproteinemias , Dermatopatias , Medula Óssea , Humanos , Paraproteinemias/complicações , Dermatopatias/etiologia
6.
Cutis ; 108(2): 78-83, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34735317

RESUMO

Complementary alternative medicine (CAM) is a rapidly emerging field with prevalent use reported among dermatologic patients. However, the effectiveness and safety among different treatments notably varies. A review of the current literature regarding CAM for the treatment of 3 common conditions-atopic dermatitis (AD), psoriasis, and alopecia areata (AA)-is reported to help familiarize dermatologists with the most up-to-date information on this topic.


Assuntos
Alopecia em Áreas , Terapias Complementares , Dermatite Atópica , Dermatopatias , Dermatite Atópica/terapia , Suplementos Nutricionais , Humanos , Dermatopatias/terapia
7.
J Assoc Physicians India ; 69(11): 11-12, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34781609

RESUMO

BACKGROUND: Dermatological disorders are common in patients being treated in intensive care units (ICU). However, they are often neglected in context of a critically ill patient. Very few studies focusing on these dermatoses have been undertaken. OBJECTIVES: To determine the prevalence and spectrum of dermatological disorders in patients being treated in medical ICU of a tertiary care centre. METHODS: This was a descriptive study conducted over a period of one year. All the patients admitted in the medical ICU were examined for the presence of any preexisting or newly developed dermatological disorder. Dermatological disorders were initially classified into infective and non-infective disorders. Patients with dermatological findings were classified into two groups: those who survived and those who died; which were compared with each other with respect to age and sex distribution, length of ICU stay and dermatological findings. RESULTS: Out of 776 cases admitted in ICU during the study period, dermatological disorders were observed in 164 (21.13%) cases. Life-threatening dermatological disorders were seen in 3.05% cases. Twenty nine (17.68%) patients with dermatological findings died. Amongst these cases, infectious dermatological disorders were significantly less common; while no significant difference was noticed in context of reactive dermatological disorders. CONCLUSION: Dermatological disorders in ICU are common and have a wide spectrum. They often need treatment and may be indicative of underlying potentially fatal systemic illness. Besides, a subset of cutaneous lesions may develop in response to various medical interventions, immunosuppression and immobility. Knowledge of such dermatoses is thus, essential, both for the intensivist and dermatologist.


Assuntos
Dermatopatias , Cuidados Críticos , Estado Terminal , Hospitalização , Humanos , Unidades de Terapia Intensiva , Tempo de Internação , Dermatopatias/epidemiologia , Centros de Atenção Terciária
8.
Comput Intell Neurosci ; 2021: 9409508, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34790232

RESUMO

Melanoma is a type of skin cancer that often leads to poor prognostic responses and survival rates. Melanoma usually develops in the limbs, including in fingers, palms, and the margins of the nails. When melanoma is detected early, surgical treatment may achieve a higher cure rate. The early diagnosis of melanoma depends on the manual segmentation of suspected lesions. However, manual segmentation can lead to problems, including misclassification and low efficiency. Therefore, it is essential to devise a method for automatic image segmentation that overcomes the aforementioned issues. In this study, an improved algorithm is proposed, termed EfficientUNet++, which is developed from the U-Net model. In EfficientUNet++, the pretrained EfficientNet model is added to the UNet++ model to accelerate segmentation process, leading to more reliable and precise results in skin cancer image segmentation. Two skin lesion datasets were used to compare the performance of the proposed EfficientUNet++ algorithm with other common models. In the PH2 dataset, EfficientUNet++ achieved a better Dice coefficient (93% vs. 76%-91%), Intersection over Union (IoU, 96% vs. 74%-95%), and loss value (30% vs. 44%-32%) compared with other models. In the International Skin Imaging Collaboration dataset, EfficientUNet++ obtained a similar Dice coefficient (96% vs. 94%-96%) but a better IoU (94% vs. 89%-93%) and loss value (11% vs. 13%-11%) than other models. In conclusion, the EfficientUNet++ model efficiently detects skin lesions by improving composite coefficients and structurally expanding the size of the convolution network. Moreover, the use of residual units deepens the network to further improve performance.


Assuntos
Melanoma , Dermatopatias , Neoplasias Cutâneas , Humanos , Processamento de Imagem Assistida por Computador , Melanoma/diagnóstico por imagem , Redes Neurais de Computação , Neoplasias Cutâneas/diagnóstico por imagem
9.
Artigo em Inglês | MEDLINE | ID: mdl-34769769

RESUMO

BACKGROUND: In the course of plaque psoriasis, tissue resident memory cells (TRM) are responsible for the phenomenon of "immune memory" of lesions, i.e., the appearance of recurrences of lesions in the same location, as well as Koebner phenomenon. We present results determining the location and amount of TRM in psoriatic lesions in patients suffering from plaque psoriasis, as well as an analysis of the relationship between TRM markers expression and the duration and severity of the disease. METHODS: TRM markers (CD4, CD8, CD103, CD69, CD49, CXCR6) and tissue expression of cytokines (IL-17, IL-22) in the lesional psoriatic skin of 32 patients compared with 10 healthy skin samples were evaluated by immunohistochemistry. RESULTS: The presence of TRM markers in both the epidermis and skin with psoriatic eruptions was demonstrated in much higher amounts compared with the skin of healthy volunteers. A significant positive relationship was demonstrated between the expression of TRM markers in patients with plaque psoriasis and the duration of skin lesions. There was no relationship between the amount of TRM and the severity of plaque psoriasis. CONCLUSIONS: A thorough understanding of the mechanisms responsible for the development and relapse of plaque psoriasis may contribute to the implementation of more effective therapies.


Assuntos
Psoríase , Dermatopatias , Voluntários Saudáveis , Humanos , Memória Imunológica , Pele
10.
BMJ Case Rep ; 14(11)2021 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-34728508

RESUMO

An 81-year-old man was admitted under the care of a plastic surgery team with a 10-day history of a painful left lower leg skin lesion after a punch biopsy of a naevus. His background history includes end-stage kidney disease secondary to hypertensive nephropathy, on intermittent haemodialysis via fistula. Other significant background history includes stroke, hypertension and ischaemic heart disease with coronary artery stents. There was no history of warfarin use. He was initially treated with a 5-day course of oral antibiotics with no improvement. He was referred to the hospital where he was admitted under the plastic surgery team who had completed the punch biopsy for intravenous antibiotics for presumed cellulitis. During his admission, the nephrology service were consulted to prescribe routine inpatient haemodialysis. Further history taking and wound review identified a 10-day history of an extremely painful skin lesion with an eschar and surrounding dusky, purpuric skin. Given the disproportionate pain and black eschar which are not in keeping with cellulitis, a diagnosis of calciphylaxis was made. He was commenced sodium thiosulfate on haemodialysis.


Assuntos
Calciofilaxia , Falência Renal Crônica , Dermatopatias , Idoso de 80 Anos ou mais , Calciofilaxia/diagnóstico , Calciofilaxia/etiologia , Humanos , Falência Renal Crônica/complicações , Falência Renal Crônica/terapia , Masculino , Dor/etiologia , Diálise Renal/efeitos adversos
11.
Clin Dermatol ; 39(5): 829-839, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34785010

RESUMO

The microbiome plays a significant role in human health, homeostasis, immune system, and disease pathogenesis. Disrupted communication between the microbiome and host has been extensively studied in gastrointestinal diseases. To a lesser extent, there is emerging research on the skin microbiome and its connection with the gut, referred to as the gut-skin axis and its effects on dermatologic conditions. A basic overview will be provided of the gut and skin microbiome with a focus on the impact of this connection on cutaneous diseases, such as psoriasis, atopic dermatitis, rosacea, acne vulgaris, photoaging, and cutaneous wounds. In addition, we shall discuss nutrition-based approaches mediated through the gut-skin axis and topical treatments that could serve as potential adjunctive management by manipulation of the microbiome. In particular, there is a growing body of research on oral probiotics, prebiotics, and dietary modifications that may help improve symptoms for a variety of dermatologic conditions in select demographic groups.


Assuntos
Dermatite Atópica , Microbiota , Probióticos , Dermatopatias , Humanos , Pele
12.
Clin Dermatol ; 39(5): 920-926, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34785023

RESUMO

An increasing body of evidence has been produced in a very limited period to improve the understanding of skin involvement in the current coronavirus 2019 disease pandemic, and how this novel disease affects the management of dermatologic patients. A little explored area is represented by the therapeutic approach adopted for the different skin manifestations associated with the infection. An overview of the current scenario is provided, through review of the English-language literature published until October 30, 2020, and comparison with the personal experience of the authors. As dermatologists, our primary aim is to support patients with the highest standard of care and relieve suffering, even with lesions not life-threatening. With asymptomatic COVID-19 patients, patient discomfort related to skin lesions should not be undervalued and intervention to accelerate healing should be provided. Consensus protocols are warranted to assess the best skin-targeted treatments in COVID-19 patients.


Assuntos
COVID-19 , Dermatopatias , Consenso , Humanos , Pandemias , SARS-CoV-2 , Dermatopatias/tratamento farmacológico , Dermatopatias/etiologia
13.
Laeknabladid ; 107(12): 597-602, 2021 Dec.
Artigo em Islandês | MEDLINE | ID: mdl-34821576

RESUMO

In the summer of 2020, an elderly woman in her eighties sought medical attention due to headache and visual disturbances. The diagnosis was unclear, she became blind on both eyes and developed extended scalp necrosis. Later it was clear that these symptoms were due to accelerating symptoms of giant cell arteritis (GCA). GCA is one of the most common disease form of vasculitis and can have various symptoms. In this report, we describe a case of an advanced disease course, discuss the main symptoms, diagnosis and treatment.


Assuntos
Arterite de Células Gigantes , Dermatopatias , Idoso , Cegueira/diagnóstico , Cegueira/etiologia , Feminino , Arterite de Células Gigantes/complicações , Arterite de Células Gigantes/diagnóstico , Humanos , Necrose , Couro Cabeludo
14.
Minerva Surg ; 76(5): 423-428, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34814654

RESUMO

BACKGROUND: The ostomy patient's quality of life also depends on their peristomal health and thus first and foremost on keeping healthy peristomal skin. This is by no means an easy task, given that the incidence of peristomal skin disorders can be a factor in up to 80% of cases. Over the past 15 years, several tools have been developed to classify peristomal skin lesions to facilitate the management of the problem. These tools, however, meet the needs of healthcare professionals and those of patients. Hence the decision to work on an advanced version of the SACS©, currently the most widely used tool, with the setting up of the SACS Evolution Consensus Group. METHODS: By applying the simplified Delphi method, the SACS Evolution Consensus Group critically re-read what had been garnered from the literature in the light of their personal clinical experience, identified the key issues to be addressed, and processed and refined the relevant statements. This made it possible to achieve the challenging objective of creating a peristomal health tool to help prevent peristomal skin lesions. RESULTS: SACS Evolution is, indeed, a promising tool for preventing peristomal lesions. It is structured on two different levels, one for the patient and one for the healthcare professional, each characterized by specific language and based on an innovative concept of healthy peristomal skin, which is essential for those who work on peristomal health. CONCLUSIONS: The SACS Evolution Consensus Group thus aims to validate this peristomal health tool and has already started a validation process so that the tool can be used in clinical practice.


Assuntos
Estomia , Dermatopatias , Humanos , Qualidade de Vida , Pele , Higiene da Pele , Dermatopatias/prevenção & controle
15.
Pan Afr Med J ; 39: 286, 2021.
Artigo em Francês | MEDLINE | ID: mdl-34754363

RESUMO

Naevus unius lateris is a rare congenital hamartoma, originating from the ectoderm. It is considered as a verruquous variant of the epidermal naevus. Given its extensive unilateral distribution, it is frequently associated with neurological, musculoskeletal, auditory and visual abnormalities. We here report the case of a 9-year-old child with nevus unius lateris associated with neurological and eye abnormalities.


Assuntos
Hamartoma/diagnóstico , Nevo/diagnóstico , Dermatopatias/diagnóstico , Criança , Anormalidades do Olho/diagnóstico , Hamartoma/congênito , Hamartoma/patologia , Humanos , Masculino , Nevo/congênito , Nevo/patologia , Dermatopatias/congênito , Dermatopatias/patologia
17.
Nursing ; 51(12): 20-26, 2021 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-34807856

RESUMO

ABSTRACT: Pulmonary sarcoidosis is a multisystem disease characterized by sarcoid granulomas, vasculitis, and degrees of necrosis with unknown etiology. This article discusses the pathophysiology of sarcoidosis and its medical and nursing management. A case presentation highlights some long-term concerns with this chronic disease.


Assuntos
Enfermeiras e Enfermeiros , Sarcoidose Pulmonar , Sarcoidose , Dermatopatias , Granuloma , Humanos , Sarcoidose/diagnóstico , Sarcoidose Pulmonar/diagnóstico
18.
Clin Dermatol ; 39(4): 555-562, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34809761

RESUMO

Dermatology is one of the few visual specialties; much can be seen with the naked eye, yet many tools and devices can facilitate the diagnosis of cutaneous maladies. There has been significant progress in diagnostic techniques in recent decades with the advent of artificial intelligence and teledermatology. Such advancements reflect principles of long-standing aids, whereas others embody novel techniques and concepts. These bedside tools range from simple magnifiers and binocular loupes to reflectance confocal microscopes and ultrasounds. The cornerstone diagnostic techniques, including the potassium hydroxide examination and the Tzanck smear, remain highly useful. Although visual examination often permits an accurate diagnosis of a skin disease, the clinician is now even further equipped. Just as the microscope did 4 centuries ago, newer advances will continue to revolutionize the practice of medicine.


Assuntos
Dermatologia , Dermatopatias , Inteligência Artificial , Humanos , Pele , Dermatopatias/diagnóstico , Coloração e Rotulagem
19.
Clin Dermatol ; 39(4): 624-634, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34809767

RESUMO

During the past decade, noninvasive imaging has emerged as a valuable tool in clinical dermatology and dermatologic research. Optical coherence tomography (OCT) is one such type of noninvasive imaging. OCT uses the principle of interferometry to produce real-time images. A low-power diode laser shines infrared light onto tissues, which reflects back to an optical fiber interferometer. Using time delay and the backscattered light intensity, a two-dimensional image akin to an ultrasound is rendered. We review the history, types, and modalities of OCT, plus the many applications of frequency domain, high definition, and dynamic OCT in practice, including its utility in diagnosis, monitoring, and grading disease severity in a variety of cutaneous conditions.


Assuntos
Dermatopatias , Tomografia de Coerência Óptica , Humanos
20.
Clin Dermatol ; 39(4): 635-642, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34809768

RESUMO

The dermatoscope has gained tremendous popularity among dermatologists as an adjunctive tool to better visualize subsurface structures and identify patterns that may improve the diagnosis of a wide range of skin diseases. Initially, the pigmented lesion experts who were the early adopters promoted the use of the dermatoscope to increase diagnostic accuracy of early melanomas and decrease the harvesting of benign lesions. With current near universal adoption of the diagnostic technique by dermatologists, the dermatoscope is now employed to help identify a wide variety of inflammatory, infectious, and vascular conditions of the skin, hair, and nails, resulting in the emergence of several branches of dermatoscopy-inflammoscopy, trichoscopy, onychoscopy, and entodermoscopy. The future of dermatoscopy will involve incorporation of artificial intelligence that will make the assessment process increasingly objective, more accurate, and universally available. Despite the wide acceptance and adoption of dermatoscopy, the overall impact of its widespread use still remains unclear, whether it has decreased biopsy rates of benign lesions, reduced health care costs, or improved patient outcomes.


Assuntos
Melanoma , Dermatopatias , Neoplasias Cutâneas , Inteligência Artificial , Dermoscopia , Humanos , Melanoma/diagnóstico por imagem , Dermatopatias/diagnóstico por imagem , Neoplasias Cutâneas/diagnóstico por imagem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...