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1.
J Drugs Dermatol ; 23(6): 472-476, 2024 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-38834210

RESUMO

The debate surrounding the benefits versus harms of blue light have become a topic of interest recently due to increased exposure. Blue light therapy has been utilized with some success in a variety of dermatologic conditions. However, potential harms have also been documented. Currently, there is no evidence to suggest a necessity for blue light photoprotection, but there are products available with proven efficacy for those desiring protection. J Drugs Dermatol. 2024;23(6):472-476.     doi:10.36849/JDD.7665.


Assuntos
Luz , Pele , Humanos , Luz/efeitos adversos , Pele/efeitos da radiação , Dermatopatias/etiologia , Dermatopatias/terapia , Fototerapia/métodos , Fototerapia/efeitos adversos , Luz Azul
2.
Arch Dermatol Res ; 316(7): 390, 2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38878086

RESUMO

Calcinosis cutis is a condition that is commonly associated with autoimmune connective tissue diseases. It is characterized by the deposition of insoluble calcium salts in the skin and subcutaneous tissue, which can cause pain, impair function, and have significant impacts on quality of life. Calcinosis cutis is difficult to manage because there is no generally accepted treatment: evidence supporting treatments is mostly comprised of case reports and case series, sometimes yielding mixed findings. Both pharmacologic and procedural interventions have been proposed to improve calcinosis cutis, and each may be suited to different clinical scenarios. This review summarizes current treatment options for calcinosis cutis, with discussion of recommendations based on patient-specific factors and disease severity.


Assuntos
Doenças Autoimunes , Calcinose , Doenças do Tecido Conjuntivo , Dermatopatias , Humanos , Calcinose/diagnóstico , Calcinose/terapia , Calcinose/etiologia , Calcinose/patologia , Calcinose/imunologia , Doenças do Tecido Conjuntivo/complicações , Doenças do Tecido Conjuntivo/diagnóstico , Dermatopatias/etiologia , Dermatopatias/terapia , Dermatopatias/diagnóstico , Dermatopatias/imunologia , Doenças Autoimunes/terapia , Doenças Autoimunes/complicações , Doenças Autoimunes/diagnóstico , Doenças Autoimunes/imunologia , Qualidade de Vida , Pele/patologia , Pele/imunologia , Calcinose Cutânea
5.
AAPS PharmSciTech ; 25(5): 122, 2024 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-38816546

RESUMO

Prinsepia utilis seed oil (PUSO) is a natural medication obtained from Prinsepia utilis Rogle seed, which has been used for the treatment of skin diseases. The study aims to prepare ethosomes with high drug loading as a water-soluble transdermal vehicle to enhance the transdermal delivery of PUSO. PUSO-loaded ethosomes (PEs) were prepared using a cold method, and optimized by an orthogonal experimental design with entrapment efficiency (EE) as the dependent variable. The PEs prepared with the optimized formulation showed good stability, with a spherical shape under transmission electron microscopy (TEM), average particle size of 39.12 ± 0.85 nm, PDI of 0.270 ± 0.01, zeta potential of -11.3 ± 0.24 mV, and EE of 95.93 ± 0.43%. PEs significantly increased the skin deposition of PUSO compared to the PUSO suspension (P < 0.001). Moreover, the optimum formula showed significant ameliorative effects on ultraviolet B (UVB) irradiation-associated macroscopic and histopathological changes in mice skin. Therefore, PEs represent a promising therapeutic approach for the treatment of UVB-induced skin inflammation, with the potential for industrialization.


Assuntos
Administração Cutânea , Tamanho da Partícula , Óleos de Plantas , Sementes , Pele , Raios Ultravioleta , Animais , Raios Ultravioleta/efeitos adversos , Camundongos , Óleos de Plantas/farmacologia , Óleos de Plantas/administração & dosagem , Óleos de Plantas/química , Pele/efeitos dos fármacos , Pele/metabolismo , Pele/patologia , Absorção Cutânea/efeitos dos fármacos , Química Farmacêutica/métodos , Dermatopatias/tratamento farmacológico , Dermatopatias/etiologia , Masculino , Sistemas de Liberação de Medicamentos/métodos
6.
Br J Hosp Med (Lond) ; 85(4): 1-8, 2024 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-38708977

RESUMO

Skin ageing is a multifaceted process impacted by both intrinsic and extrinsic factors. Drier and less elastic skin with declining sebum levels in older age makes ageing skin more vulnerable to various skin conditions, including infections, inflammatory dermatoses, and cancers. Skin problems are common among older adults due to the effects of ageing, polypharmacy and multimorbidity impacting not only physical health but wellbeing and quality of life. In the UK, older adults in geriatric medicine wards may present with various skin conditions. Hospitalised older individuals may have undiagnosed skin problems unrelated to their admission, making hospitalisation an opportunity to manage unmet needs. Asteatotic eczema, incontinence associated dermatitis, seborrhoeic dermatitis, chronic venous insufficiency, and cellulitis are common disorders clinicians encounter in the geriatric medicine wards. This article outlines the importance of performing comprehensive skin assessments to help diagnose and commence management for these common conditions.


Assuntos
Dermatopatias , Humanos , Idoso , Dermatopatias/terapia , Dermatopatias/diagnóstico , Dermatopatias/etiologia , Envelhecimento da Pele , Eczema/diagnóstico , Eczema/terapia , Celulite (Flegmão)/diagnóstico , Celulite (Flegmão)/terapia , Dermatite Seborreica/terapia , Dermatite Seborreica/diagnóstico , Insuficiência Venosa/terapia , Insuficiência Venosa/complicações , Insuficiência Venosa/diagnóstico
7.
Curr Allergy Asthma Rep ; 24(6): 323-330, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38733510

RESUMO

PURPOSE OF REVIEW: This paper explores how environmental factors influence allergic skin diseases, including atopic dermatitis (AD), contact dermatitis (CD), urticaria, angioedema, and reactions to drugs and insect bites. RECENT FINDINGS: Research indicates a significant impact of environmental elements on allergic skin diseases. High air pollution levels exacerbate symptoms, while climate change contributes to increased skin barrier dysfunction, particularly affecting AD. Allergen prevalence is influenced by climate and pollution. Irritants, like those in detergents and cosmetics, play a major role in CD. Plants also contribute, causing various skin reactions. Understanding the interplay between environmental factors and allergic skin diseases is crucial for effective management. Physicians must address these factors to support patient well-being and promote skin health amidst environmental changes.


Assuntos
Dermatite Atópica , Humanos , Dermatite Atópica/imunologia , Dermatite Atópica/etiologia , Alérgenos/imunologia , Exposição Ambiental/efeitos adversos , Meio Ambiente , Hipersensibilidade/imunologia , Mudança Climática , Dermatopatias/imunologia , Dermatopatias/etiologia , Poluição do Ar/efeitos adversos , Animais , Urticária/imunologia , Urticária/etiologia
8.
Andes Pediatr ; 95(2): 136-142, 2024 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-38801360

RESUMO

Molluscum contagiosum (MC) is a common viral infection in children, immunocompromised, and sexually active adults. Its usual clinical presentation is 2-5 mm, whitish or skin-colored papules, with a shiny surface and central umbilication, generally clustered and randomly distributed over the skin surface. Dermoscopy reveals yellowish-white polylobulated structures with peripheral telangiectasia. Diagnosis is usually clinical supported by dermoscopy. However, in some cases, inflammatory manifestations can be associated with this infection and can mimic other dermatological conditions, making the diagnosis difficult and leading to unnecessary treatments. The objective of this article is to describe the main skin reactions associated with MC infection in order to provide a diagnostic and initial management tool for clinicians dealing with these conditions. Reported manifestations include the BOTE sign, perilesional eczema, Gianotti-Crosti syndrome-like reaction, ID reaction, erythema annulare centrifugum, erythema multiforme, folliculitis, white halo, and atypical manifestations (giant, disseminated, necrotic, polypoidal, and nodular lesions, pseudocysts, abscesses). In pediatric patients with the clinical manifestations described above, infection by molluscum contagiosum pox virus should be considered among the differential diagnoses, and referral to a dermatologist should be made in selected cases.


Assuntos
Molusco Contagioso , Humanos , Molusco Contagioso/diagnóstico , Criança , Diagnóstico Diferencial , Dermoscopia , Dermatopatias/etiologia , Dermatopatias/diagnóstico
9.
Arch Dermatol Res ; 316(6): 292, 2024 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-38819524

RESUMO

Scientists from various areas of the world indicate in their studies that skin lesions occur in the course of infection with the SARS-CoV-2 virus. This article is a review of the most frequently described cutaneous manifestations of SARS-CoV-2 virus infection and the potential pathophysiology of their development, as well as information on abnormalities in histopathological tests. The article describes the impact of some factors related to the COVID-19 pandemic on the exacerbation of chronic dermatological diseases. This work was constructed on the basis of 142 research studies, reviews, and meta-analyses, focusing on the methods and materials used in individual works as well as the results and conclusions resulting from them. Some skin lesions may be a potential prognostic marker of the course of the disease and may also be a prodromal symptom or the only symptom of SARS-CoV-2 virus infection. Stress related to the COVID-19 pandemic may exacerbate some chronic dermatological diseases. A correlation was observed between the type of skin lesions and the patient's age. The occurrence of skin diseases may also be influenced by drugs used to treat infections caused by SARS-CoV-2. A relationship was observed between the patient's ethnic origin and skin lesions occurring in the course of COVID-19. There is a need to further diagnose the cutaneous manifestations of SARS-CoV-2 infection and to learn the detailed pathomechanism of their occurrence in order to better understand the essence of the disease and find an appropriate treatment method.


Assuntos
COVID-19 , SARS-CoV-2 , Humanos , COVID-19/epidemiologia , COVID-19/complicações , Adulto , Adulto Jovem , Dermatopatias/epidemiologia , Dermatopatias/etiologia , Pele/patologia , Pele/virologia
10.
Cutis ; 113(4): 159-166, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38820096

RESUMO

Inflammatory bowel disease (IBD) can cause micronutrient deficiencies that have cutaneous manifestations. Dermatologists may be the first to identify an undiagnosed micronutrient deficiency in the affected population. The approach to monitoring and repleting a micronutrient deficiency may be impacted by factors such as IBD activity and potential interactions between supplements and medications used to treat IBD. In this article, we review the most common micronutrient deficiencies observed in patients with IBD and their associated cutaneous manifestations. We also provide guidance for monitoring and supplementing each micronutrient discussed.


Assuntos
Doenças Inflamatórias Intestinais , Micronutrientes , Humanos , Doenças Inflamatórias Intestinais/complicações , Micronutrientes/deficiência , Suplementos Nutricionais , Dermatopatias/etiologia
11.
J Investig Med High Impact Case Rep ; 12: 23247096241255840, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38767173

RESUMO

Cutaneous paraneoplastic syndromes due to Hodgkin lymphoma present with a wide spectrum of clinical manifestations from generalized pruritus to exfoliative erythroderma. We summarize the clinical findings and outcomes of 14 patients with Hodgkin lymphoma and associated cutaneous paraneoplastic syndromes treated at Mayo Clinic over the past 3 decades. Cutaneous paraneoplastic syndromes may be present at the time of lymphoma diagnosis, whereas in other patients, it may appear at the time of relapse, including patients with initial absence of cutaneous manifestations during the initial lymphoma presentation. Our results indicate that complete resolution of the paraneoplastic syndrome is associated with significantly improved overall survival. Recognition of cutaneous paraneoplastic syndromes is a crucial surrogate of relapsed malignancy and treatment requires targeting the underlying malignancy.


Assuntos
Doença de Hodgkin , Síndromes Paraneoplásicas , Humanos , Doença de Hodgkin/complicações , Doença de Hodgkin/diagnóstico , Síndromes Paraneoplásicas/diagnóstico , Masculino , Feminino , Pessoa de Meia-Idade , Adulto , Idoso , Adulto Jovem , Dermatopatias/etiologia , Dermatopatias/diagnóstico , Adolescente
12.
Rev Med Suisse ; 20(876): 1063-1068, 2024 May 29.
Artigo em Francês | MEDLINE | ID: mdl-38812337

RESUMO

Skin disorders are common in diabetes, affecting both patients with type 1 and type 2 diabetes. These cutaneous manifestations can be classified into three categories: dermatoses associated with the presence of diabetes, cutaneous complications of diabetes (acute and chronic) and dermatoses linked to antidiabetic treatments. These conditions vary considerably in terms of severity (from insignificant cosmetic problems to life-threatening) and prevalence (from relatively frequent to rare). Despite the high prevalence of diabetes and associated skin disorders, the dermatological manifestations of diabetes are generally neglected and often under-diagnosed. Failure to diagnose and treat skin disorders at an early stage can lead to clinical worsening, whereas early detection and treatment can reduce the risk of serious complications.


Chez les personnes atteintes d'un diabète de type 1 ou 2, les atteintes cutanées sont fréquentes. Elles peuvent être classées en trois catégories : les dermatoses associées à la présence du diabète, ses complications cutanées (aiguës et chroniques) et les dermatoses liées aux traitements antidiabétiques. Ces atteintes varient considérablement en gravité (allant de préoccupations esthétiques banales à potentiellement mortelles) et en prévalence (relativement fréquentes à rares). Malgré la prévalence élevée du diabète et des atteintes cutanées associées, les manifestations dermatologiques sont généralement négligées et souvent sous-diagnostiquées. L'absence de diagnostic et de traitement à un stade précoce peut entraîner une aggravation clinique dermatologique. La détection et le traitement précoces de ces atteintes peuvent réduire le risque de complications graves.


Assuntos
Complicações do Diabetes , Dermatopatias , Humanos , Dermatopatias/diagnóstico , Dermatopatias/etiologia , Dermatopatias/epidemiologia , Complicações do Diabetes/diagnóstico , Complicações do Diabetes/epidemiologia , Diabetes Mellitus Tipo 2/diagnóstico , Diabetes Mellitus Tipo 2/epidemiologia , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 1/diagnóstico , Diabetes Mellitus Tipo 1/complicações , Diabetes Mellitus Tipo 1/epidemiologia , Prevalência
13.
Ital J Dermatol Venerol ; 159(3): 344-348, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38808460

RESUMO

BACKGROUND: Sarcoidosis is a multisystemic granulomatous disease which not only affect the skin but can also involve the lymph nodes, eyes, and lungs. Subcutaneous sarcoidosis (SCS), is a rare form of sarcoidosis which is generally more prevalent in women in their 40s and 50s, characterized by subcutaneous, flesh-colored nodules, mostly localized on the limbs. A retrospective study to investigate clinical features and response to treatment in patients affected by SCS. METHODS: All patients with systemic and/or cutaneous sarcoidosis visited in our clinic hospital between 2012 and 2022. Out of this group, clinical features, and management of SCS patients were analyzed. RESULTS: Out of 102 patients with specific lesions of cutaneous sarcoidosis, with or without systemic involvement, 13 (13%) were diagnosed with SCS. CONCLUSIONS: Our study confirms that systemic involvement in SCS is the prevalent finding as expected. Moreover, SCS patients have a relatively good prognosis, and systemic treatment does not differ from first-line therapies for cutaneous sarcoidosis.


Assuntos
Sarcoidose , Dermatopatias , Humanos , Feminino , Estudos Retrospectivos , Pessoa de Meia-Idade , Masculino , Dermatopatias/etiologia , Adulto , Idoso , Tela Subcutânea/patologia
14.
BMC Immunol ; 25(1): 30, 2024 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-38734636

RESUMO

BACKGROUND: Immune-mediated necrotizing myopathy (IMNM) is an idiopathic inflammatory myopathy (IIM). Though patients with IMNM were not considered to show skin rash, several reports have showed atypical skin conditions in patients with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibody-positive IMNM (HMGCR-IMNM). The incidence and phenotype of skin conditions in patients with HMGCR-IMNM are not fully known. RESULTS: Among the 100 IIM patients diagnosed from April 2015 through August 2022, 34 (34%) presented some form of skin condition, with 27 having typical skin rashes; this included 13 patients with dermatomyositis (DM), 8 with anti-synthetase syndrome (ASS), and 6 with IMNM. Meanwhile, 8 of 19 patients with HMGCR-IMNM (42%) presented atypical skin lesions, but no patients with other IIMs did (p < 0.001). Skin eruption with ash-like scales was observed in four HMGCR-IMNM patients, and non-scaly red patches and lumps in the other four patients; accordingly, their skin manifestations were considered as other dermal diseases except for IIM. However, skin and muscle biopsies revealed the atypical skin conditions of patients with HMGCR-IMNM to have the same pathological background, formed by Bcl-2-positive lymphocyte infiltrations. CONCLUSIONS: HMGCR-IMNM patients frequently have atypical skin conditions of the neck and back. Skin biopsy specimens from these lesions showed the same Bcl-2-positive lymphocytic infiltrations as muscle biopsy specimens regardless of the different gross dermal findings. Thus, such atypical skin conditions may be suggestive for HMGCR-IMNM.


Assuntos
Autoanticorpos , Hidroximetilglutaril-CoA Redutases , Miosite , Pele , Humanos , Hidroximetilglutaril-CoA Redutases/imunologia , Feminino , Masculino , Pessoa de Meia-Idade , Autoanticorpos/imunologia , Autoanticorpos/sangue , Adulto , Pele/patologia , Pele/imunologia , Miosite/imunologia , Miosite/diagnóstico , Idoso , Dermatopatias/imunologia , Dermatopatias/etiologia , Doenças Musculares/imunologia , Doenças Musculares/diagnóstico , Biópsia
15.
Ned Tijdschr Geneeskd ; 1682024 May 23.
Artigo em Holandês | MEDLINE | ID: mdl-38780190

RESUMO

Extra-intestinal manifestations (EIM) associated with Crohn's disease (CD) are frequently observed and can manifest as either the initial symptom or develop later in the disease course following gastrointestinal symptoms. The most common EIM affect the joints, skin, or eyes, with some correlating with active CD activity while others may occur during periods of inactivity. EIM can affect both pediatric and adult CD patients, potentially reducing their quality of life if not promptly identified and treated. Thus, emphasizing the prevalence and clinical presentation is essential to initiate appropriate diagnostic assessments and effectively treat both EIM and the underlying CD. In this case series, we present two pediatric and one adult case where EIM preceded CD diagnosis, resulting in delayed CD diagnosis. Additionally, we outline the most prevalent EIM, their epidemiology, and associated symptoms.


Assuntos
Doença de Crohn , Humanos , Doença de Crohn/complicações , Doença de Crohn/diagnóstico , Masculino , Feminino , Adulto , Criança , Qualidade de Vida , Dermatopatias/etiologia , Dermatopatias/diagnóstico , Adolescente , Oftalmopatias/etiologia , Oftalmopatias/diagnóstico
17.
Semin Oncol Nurs ; 40(3): 151618, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38622044

RESUMO

OBJECTIVES: To identify the prevalence and type of central venous access device-associated skin complications for adult cancer patients, describe central venous access device management practices, and identify clinical and demographic characteristics associated with risk of central venous access device-associated skin complications. METHODS: A prospective cohort study of 369 patients (626 central venous access devices; 7,682 catheter days) was undertaken between March 2017 and March 2018 across two cancer care in-patient units in a large teaching hospital. RESULTS: Twenty-seven percent (n = 168) of participants had a central venous access device-associated skin complication. In the final multivariable analysis, significant (P < .05) risk factors for skin complications were cutaneous graft versus host disease (2.1 times greater risk) and female sex (1.4 times greater risk), whereas totally implanted vascular access device reduced risk for skin complications by two-thirds (incidence risk ratio 0.37). CONCLUSION: Central venous access device-associated skin complications are a significant, potentially avoidable injury, requiring cancer nurses to be aware of high-risk groups and use evidence-based preventative and treatment strategies. IMPLICATIONS FOR PRACTICE: This study has confirmed how common these potentially preventable injuries are. Therefore, the prevalence of these complications could be reduced by focusing on improvements in skin assessment, reductions in central venous access device dressing variation and improving clinician knowledge of this injury.


Assuntos
Cateterismo Venoso Central , Neoplasias , Humanos , Feminino , Masculino , Estudos Prospectivos , Pessoa de Meia-Idade , Idoso , Adulto , Cateterismo Venoso Central/efeitos adversos , Cateteres Venosos Centrais/efeitos adversos , Dermatopatias/etiologia , Dermatopatias/epidemiologia , Fatores de Risco , Idoso de 80 Anos ou mais , Estudos de Coortes
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