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A patient in his 70s, admitted to the cardiac intensive care unit with cardiogenic shock, unexpectedly presented with nasal myiasis during a workup for persistently elevated inflammatory markers. CT scans revealed sinusitis and bronchial secretions, while bronchoscopy identified mucus with positive pathogen testing. Nasal endoscopy was crucial in diagnosing myiasis, and immediate mechanical removal of larvae was performed. Definitive treatment involved surgical debridement, turbinectomy and sinus cleansing, leading to a successful recovery without complications. This case emphasises the importance of considering nasal myiasis as a rare but potential cause of sinusitis in critically ill patients, even in non-endemic regions. Early diagnosis using appropriate imaging and endoscopic techniques, followed by prompt treatment, is essential for preventing severe complications. Increased awareness among healthcare professionals is vital for the timely recognition and management of this condition in critical care settings.

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INTRODUCTION: Acute pancreatitis (AP) is a common and potentially lethal disease. Approximately 10-20% of the patients progress to necrotizing pancreatitis (NP). The step-up approach is the gold standard approach to managing an infected necrotizing pancreatitis with acceptable morbidity and mortality rates. Video-assisted retroperitoneal debridement (VARD) has been described as a safe and feasible approach with high success rates. Multiple studies in the American, European, and Asian populations evaluating the outcomes of VARD have been published; nevertheless, outcomes in the Latin American population are unknown. This study aims to describe a single-center experience of VARD for necrotizing pancreatitis in Colombia with a long-term follow-up. METHODS: A prospective cohort study was conducted between 2016 and 2024. All patients over 18 years old who underwent VARD for necrotizing pancreatitis were included. Demographic, clinical variables, and postoperative outcomes at 30-day follow-up were described. RESULTS: A total of 12 patients were included. The mean age was 55.9 years old (SD 13.73). The median follow-up was 365 days (P25 60; P75 547). Bile origin was the most frequent cause of pancreatitis in 90.1% of the patients. The mean time between diagnosis and surgical management was 78.5 days (SD 22.93). The mean size of the collection was 10.5 cm (SD 3.51). There was no evidence of intraoperative complications. The mean in-hospital length of stay was 65.18 days (SD 26.46). One patient died in a 30-day follow-up. One patient presented an incisional hernia one year after surgery, and there was no evidence of endocrine insufficiency at the follow-up. CONCLUSION: According to our data, the VARD procedure presents similar outcomes to those reported in the literature; a standardized procedure following the STEP-UP procedure minimizes the requirement of postoperative drainages. Long-term follow-up should be performed to rule out pancreatic insufficiency.

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Mucormycosis is a rare fungal infection caused by fungi of the Mucorales order that occurs in immunocompromised individuals or with loss of skin or mucosa barrier integrity. This report presents four cases of rhinocerebral mucormycosis attended at a third-level hospital in Cali (Colombia) during a period of three years. All patients had different case histories and times of evolution. All four had a previous or de novo diagnosis of type 2 diabetes mellitus, with glycated hemoglobin higher than 10% on admission. We ruled out other possible pathologies that could explain their immunocompromised condition. Mucormycosis diagnosis was made with direct visualization of hyaline coenocytic hyphae on biopsies. The basis of treatment was liposomal amphotericin B and surgical debridement. Two patients presented bacterial coinfection. One asked for voluntary discharge without having completed the treatment, and another one died. The remaining two have attended controls and had an adequate evolution.

La mucormicosis es una infección fúngica poco frecuente causada por hongos del orden Mucorales, la cual se presenta en individuos inmunocomprometidos o con pérdida de la integridad de la barrera de piel o mucosas. Se reportan cuatro casos de mucormicosis rinocerebral atendidos en un hospital de tercer nivel de Cali (Colombia) durante un periodo de tres años. Los cuatro pacientes presentaron diferentes cuadros clínicos y tiempos de evolución. Todos tenían diagnóstico de diabetes mellitus de tipo 2, de novo o previo, con una hemoglobina glucosilada de ingreso mayor del 10 % y en todos se descartaron otras enfermedades que explicaran su compromiso inmunitario. La mucormicosis se diagnosticó por la visualización directa de hifas hialinas sincitiales (coenocytic) en las biopsias tomadas. El pilar del tratamiento fue la anfotericina B liposómica junto con el desbridamiento quirúrgico. Dos pacientes presentaron coinfección bacteriana. De los cuatro, uno firmó su egreso voluntario sin completar el tratamiento y otro falleció. Los dos pacientes restantes han asistido a los controles y han mostrado una adecuada evolución.

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In chronic wound treatment, the debridement of devitalized tissue and the eradication of the biofilm must balance aggressiveness with care to protect regenerating tissues. In this study, urea, a potent chaotropic molecule, was modulated through the formation of a Natural Deep Eutectic Solvent (NADES) with betaine to develop a new debriding material (BU) suitable for application into injured dermal tissues. To evaluate BU's debriding capacity, along with its antibiofilm effect and biocompatibility, pre-clinical to clinical methods were employed. In vitro determinations using artificial and clinical slough samples indicate that BU has a high debriding capacity. Additionally, BU's de-structuring effects lead to a strong antibiofilm capability, demonstrated by a reduced bacterial load compared to the antiseptic PHMB-Betaine or medical honey, evaluated in artificial slough and ex vivo human skin. Furthermore, BU's efficacy was evaluated in a murine model of diabetic wound, demonstrating significant effects on debriding and antibiofilm capacity, similar to those observed in PHMB-Betaine and medical honey-treated animals. Finally, BU was clinically evaluated in leg ulcers, showing superiority in reduction of bacterial load and wound area compared to honey, with no adverse effects. Thus, BU represents a simple and non-biocidal option that could contributes to chronic wound care.

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Cleaning and shaping the root canal system are essential steps for performing successful endodontic therapy, and are challenging procedures in the apical region. This study aimed to conduct an ex vivo assessment of the debridement ability of the WaveOne Gold (Medium 35/.06) and TruNatomy (Medium 36/.03) systems in the apical third of round root canals of mandibular premolars. Forty-eight teeth, extracted for orthodontic or periodontal reasons, were divided into three groups (n=16), as follows: Group C, control (without instrumentation or irrigation); Group WOG, instrumentation with WaveOne Gold; Group TN, instrumentation with TruNatomy. A total of 40 mL of 2.5% sodium hypochlorite and 5 mL of 17% ethylenediamine tetraacetic acid were used per root canal in all the groups. Ten 0.5-µm serial cross-sections per specimen were obtained every 0.2 mm from a 2-mm segment of the apical region, extending from 1 to 3 mm short of the root apex. The sections were stained with hematoxylin-eosin and analyzed under a digital microscope (100x). The percentages of unprepared walls and remaining debris were quantified using ImageJ software. Generalized linear models were used to analyze the results (α=5%). Groups WOG and TN had significantly lower percentages of unprepared walls and remaining debris than Group C (p<0.05). There was no significant difference between groups WOG and TN for either of the variables studied (p>0.05). Instrumentation with the WaveOne Gold Medium and TruNatomy Medium instruments was associated with equivalent percentages of unprepared walls and remaining debris in the apical third of round canals of mandibular premolars.

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The purpose of this study was to evaluate the current scientific evidence on the effectiveness of antimicrobial photodynamic therapy (aPDT) as an adjunctive treatment to mechanical debridement in the treatment of peri-implantitis. The Preferred Reporting Items for Systematic Reviews and Meta-analyses was followed. A protocol was registered in the International Prospective Registry of Systematic Reviews (PROSPERO #CRD42022361684). The search was carried out in seven databases, with no restrictions regarding language or year of publication. Our work included studies that compared clinical periodontal parameters between individuals treated with mechanical debridement associated with aPDT and a control group of patients who had undergone mechanical debridement alone. Study selection, data extraction, and risk of bias assessment (RoB 2.0) were performed by two review authors. Meta-analysis was performed. The mean difference (MD) and a 95% confidence interval (CI) were provided. Four hundred and seven-four studies were identified, of which five studies were included. The meta-analysis demonstrated that aPDT adjunctive to mechanical debridement in subjects with peri-implantitis resulted in greater reduction in probing depth 3 months after treatment than among subjects receiving treatment with mechanical debridement. Most of the included studies exhibit a low risk of bias. Adjunctive aPDT to mechanical debridement contributes to the improvement of peri-implant clinical parameters in individuals with peri-implantitis, in particular probing depth.

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Mucormycosis, a group of opportunistic mycoses caused by Mucorales, present a significant threat to immunocompromised patients. In this report, we present the case of a 57-year-old male patient who underwent liver transplant for secondary biliary cirrhosis following inadvertent bile duct injury. Despite initial satisfactory postoperative evolution, the patient developed fever, and imaging revealed a suspicious lesion. Preliminary culture growth suggested a filamentous fungus, leading to initiation of liposomal amphotericin B. However, the lesion progressed, and a surgical debridement was necessary. During surgery, involvement of the liver dome and diaphragm was observed, and a nonanatomical hepatectomy was performed. Despite efforts, the patient's condition deteriorated, ultimately resulting in multiple organ failure and mortality. This case emphasizes the challenging nature of mucormycosis in livertransplant recipients.

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Necrotizing fasciitis (NF) is a potentially life-threatening surgical emergency. It is a rapidly progressive infection of soft tissues, and mortality is related to the degree of sepsis and the general condition of the patient. It is a rare condition that requires a rapid diagnosis and surgical treatment is aggressive debridement. There are a small number of reported cases of perforation of a rectal malignancy leading to NF of the thigh. We present a case with rectal cancer in which the sciatic foramen had provided a channel for the spread of pelvic infection into the thigh.

La fascitis necrotizante es una emergencia quirúrgica potencialmente mortal. Es una infección de tejidos blandos rápidamente progresiva y la mortalidad está relacionada con el grado de sepsis y el estado general del paciente. Es una condición poco común que requiere un diagnóstico rápido, y el tratamiento quirúrgico consiste en un desbridamiento agresivo. Existe un pequeño número de casos notificados de perforación de neoplasia maligna de recto que conduce a fascitis necrotizante del muslo. Presentamos un caso de cáncer de recto en el cual el foramen ciático fue el canal para la propagación de la infección pélvica al muslo.

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Peri-implant mucositis is characterised by inflammation of soft tissues surrounding a dental implant without associated bone loss beyond initial remodelling. Early detection and timely intervention are critical to prevent its progression to peri-implantitis. This paper focuses on various treatment options for treating peri-implant mucositis. The cornerstone of professional treatment lies in the mechanical disruption and removal of microbial biofilms around the implant. This can be achieved through careful use of manual or powered instruments, such as ultrasonic scalers or air polishing devices. However, there is a need for further research to determine the most effective single approach for treating peri-implant mucositis. Current evidence does not support the combination of mechanical debridement with locally administered antibiotics. Contrarily, evidence strongly supports the removal, cleaning, and modifications of prostheses to improve both self-performance and professional cleanability. The use of adjunctive therapies like photodynamic therapy and diode laser, in conjunction with mechanical instrumentation, is not currently recommended due to the limited strength of available evidence. Preventive measures emphasise the importance of comprehensive oral hygiene care, encompassing professional guidance and at-home practices, to manage biofilms effectively. This encompasses oral hygiene instruction, regular debridement, and maintenance care. Supporting peri-implant therapy is also vital for ongoing implant monitoring, preventing the recurrence of mucositis, and halting its progression to peri-implantitis. This multifaceted approach is key to effectively managing and treating peri-implant mucositis.

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Rhino-cerebral mucormycosis (RM) is a rare and opportunistic fungal infection observed in immune-compromised patients and metabolic imbalances such as Diabetes Mellitus. RM rapidly infiltrates blood vessels, leading to vascular thrombosis, subsequent tissue necrosis, and high mortality rates (23.6-60%). Due to its fast advancement, RM is a life-threatening condition requiring accurate clinical decisions by the medical and surgical teams. Based on the report of six cases, we emphasize the need for an early diagnosis and starting antifungal pharmacological therapy at the slightest suspicion of RM. Moreover, the restitution of metabolic balance and aggressive surgical debridement are vital steps to control RM, reducing the possibility of fatal outcomes.

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Introduction: Acute compartment syndrome (ACS) is defined as any increase in interstitial pressure within the bony-fascial compartment and consists of an adverse event in the intraoperative period, resulting from surgical positioning. Objective: To report a case of fasciotomy in the lower limbs after ACS. Method: Case report registered in a large public teaching hospital, with a highly complex care profile. Results: Patient underwent videolapa-roscopic surgery to remove endometriosis, having remained in the gynecological position for 9 hours, developing ACS in the immediate postoperative period (IPO). The patient underwent decompressive fasciotomy to treat ACS in the second postoperative period, and nine other surgical approaches to continue treatment. She remained hospitalized for 45 days. Conclusion: The training of nursing professionals, knowledge about surgical patient safety and teamwork throughout the anesthetic-surgical procedure are essential for reducing adverse events and quickly identifying and treating complications. (AU)

Introducción: El síndrome compartimental agudo (SCA) se define como cualquier aumento de la presión intersticial dentro del compartimiento óseo-fascial y consiste en un evento adverso en el período intraoperatorio, resultante de la posición quirúrgica. Objetivo: Reportar un caso de fasciotomía en los miembros inferiores después de un SCA. Método: Informe de caso registrado en un gran hospital público de enseñanza, con un perfil de atención de alta complejidad. Resultados: La paciente se sometió a una cirugía videolaparoscópica para extirpar la endometriosis, permaneciendo en posición ginecológica durante 9 horas, desarrollando SCA en el período postoperatorio inmediato (POI). La paciente se sometió a una fasciotomía descompresiva para tratar el SCA en el segundo período postoperatorio, y a otros nueve abordajes quirúrgicos para continuar el tratamiento. Permaneció hospitalizada durante 45 días. Conclusión: La formación de profesionales de enfermería, el conocimiento sobre la seguridad del paciente quirúrgico y el trabajo en equipo durante todo el procedimiento anestésico-quirúrgico son esenciales para reducir los eventos adversos y para identificar y tratar rápidamente las complicaciones. (AU)

Introdução: A síndrome compartimental aguda (SCA) é definida como qualquer elevação na pressão intersticial dentro do compartimento ósseo-fascial, e consiste em um evento adverso no período intraoperatório, decorrente do posicionamento cirúrgico. Objetivo: Relatar um caso de fasciotomia em membros inferio-res após SCA. Método: Relato de caso registrado em um hospital escola público de grande porte, com perfil assistencial de alta complexidade. Resultados: Paciente submetida à cirurgia videolaparoscópica para remoção de endometriose, tendo permanecido 9 horas em posição ginecológica, desenvolvendo SCA, no pós-operató-rio imediato (POI). A paciente foi submetida à fasciotomia descompressiva, para o tratamento da SCA no segundo pós-operatório (PO), e outras nove reabordagens cirúrgicas, para a continuidade do tratamento. Ela permaneceu hospitalizada por 45 dias. Conclusão: O treinamento dos profissionais de Enfermagem, o conhe-cimento acerca da segurança do paciente cirúrgico e o trabalho em equipe durante todo o procedimento anestésico-cirúrgico são essenciais para a diminuição dos eventos adversos e a rápida identificação e tratamento de complicações. (AU)

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This case report presents a mandible reconstruction with temporomandibular joint (TMJ) prothesis for treatment of osteomyelitis infection following a bimaxillary orthognathic and genioplasty surgeries. The patient, a 41-year-old female, presented with facial pain, difficulty in opening her mouth, and mandibular deviation four months after the initial orthognathic surgery. During the four months, the patient had experienced two more surgerys post-operative for treatment of the complications. Examination revealed mobility between osteotomy segments of the right mandibular osteotomomie between body and ramus, and Computer Tomographic scan analysis revealed osteomyelitis and non-union within the osteotomy side of the right mandible from the previous surgery. Due to the advanced state of the disease and significant bone resorption, treatment was planned in two stages, involving bone debridement and then reconstruction with a custom made extended temporomandibular joint prosthesis. The patient had no postoperative complications and achieved satisfactory functional and aesthetic outcomes. This case emphasizes the importance of careful monitoring and prompt management of postoperative complications following orthognathic surgery to prevent rare but serious complications such as osteomyelitis.

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Introdução: A higienização e o desbridamento são ferramentas que representam de forma conjunta uma etapa crucial para promover a transição da fase inflamatória para a fase proliferativa no processo de cicatrização de feridas. Objetivo: Investigar o que existe de evidência científica sobre o preparo do leito da ferida através do desbridamento. Método: Trata-se de uma revisão integrativa da literatura, realizada na base PubMed a partir da estratégia PICO tendo como questão norteadora de pesquisa: Quais evidências existem sobre os tipos de desbridamento e a efetividade no tratamento de feridas para a cicatrização? Foram incluídos todos os estudos disponíveis gratuitamente na íntegra, em português, inglês e espanhol, com um limite temporal de 5 anos e que no protocolo de tratamento foi utilizado alguma técnica de desbridamento para o preparo do leito da ferida. Resultados: A seleção de cinco artigos revelou uma ampla gama de abordagens de desbridamentos para os diferentes tipos de lesões, incluindo úlceras diabéticas, queimaduras e as úlceras de origem venosa ou mista. Em relação aos tipos de desbridamento foram encontrados os autolíticos, hidrocirúrgicos, instrumental conservador e de terapia larval para tratamento da lesão. Conclusão: A presente análise evidenciou uma variedade de técnicas eficazes em diferentes contextos clínicos, porém nem todos os tipos de desbridamento são acessíveis e viáveis para todos os tipos de paciente. Logo, é importante frisar que a condição clínica do paciente e a natureza de cada ferida são únicas e isso exigirá a individualização da terapia de desbridamento

Introduction: Cleaning and debridement are essential steps in promoting the transition from the inflammatory phase to the proliferative phase in the wound healing process. Objective: To investigate the scientific evidence regarding wound bed preparation through debridement. Method: This study is an integrative literature review conducted on PubMed using the PICO strategy, with the guiding research question: What evidence exists on the types of debridement and their effectiveness in wound healing treatment? All studies available in full text for free, in Portuguese, English, and Spanish, within a 5-year time frame, and that used some form of debridement technique for wound bed preparation in their treatment protocol were included. Results: The selection of five articles revealed a wide range of debridement approaches for different types of wounds, including diabetic ulcers, burns, and venous or mixed-origin ulcers. Types of debridement identified included autolytic, hydrosurgical, conservative instrumental, and larval therapy. Conclusion: This analysis highlighted a variety of effective techniques in different clinical contexts. However, not all types of debridement are accessible and feasible for all patients. Therefore, it is crucial to emphasize that the clinical condition of the patient and the nature of each wound are unique, requiring individualized debridement therapy

Introducción: La higienización y el desbridamiento son herramientas que, en conjunto, representan una etapa crucial para promover la transición de la fase inflamatoria a la fase proliferativa en el proceso de cicatrización de heridas. Objetivo: Investigar la evidencia científica existente sobre la preparación del lecho de la herida a través del desbridamiento. Método:Este estudio es una revisión integrativa de la literatura, realizada en la base de datos PubMed utilizando la estrategia PICO, con la pregunta de investigación guía: ¿Qué evidencias existen sobre los tipos de desbridamiento y su efectividad en el tratamiento de heridas para la cicatrización? Se incluyeron todos los estudios disponibles gratuitamente en su totalidad, en portugués, inglés y español, con un límite temporal de 5 años y que en su protocolo de tratamiento utilizaron alguna técnica de desbridamiento para la preparación del lecho de la herida. Resultados: La selección de cinco artículos reveló una amplia gama de enfoques de desbridamiento para diferentes tipos de lesiones, incluyendo úlceras diabéticas, quemaduras y úlceras de origen venoso o mixto. Entre los tipos de desbridamiento encontrados se incluyen los autolíticos, hidrocirúrgicos, instrumental conservador y terapia larval. Conclusión: Este análisis evidenció una variedad de técnicas eficaces en diferentes contextos clínicos. Sin embargo, no todos los tipos de desbridamiento son accesibles y viables para todos los pacientes. Por lo tanto, es importante enfatizar que la condición clínica del paciente y la naturaleza de cada herida son únicas, lo que requiere una individualización de la terapia de desbridamiento

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Reducir el tiempo de cicatrización de las heridas crónicas (HC), con alternativas factibles, materiales accesibles y económicos, constituye una estrategia para disminuir cronicidad de estas lesiones consideradas un problema de salud pública. Objetivo: Determinar el efecto cicatrizante del Alumbre de Potasio al 2% en heridas crónicas, Método: Se realizó un estudio descriptivo, prospectivo, de corte longitudinal, experimental, tipo ensayo clínico. La población estuvo constituida por 48 pacientes, siendo su totalidad la muestra estratificándose en dos grupos: el control (20) con tratamiento placebo y el experimental (28) tratado con Alumbre de Potasio. Todas las heridas recibieron preparación del lecho, con desbridamiento quirúrgico. Resultados: Los factores sistémicos que afectaban la cicatrización, fueron la edad ≥ 65 años (77% ), la HTA (56%), el sedentarismo (95,8%) y el edema local (35,4%); y como factores protectores, el género masculino (72,9%), el estado nutricional normal (83,3%) y la cobertura antibiótica y analgésica (100%). Predominaron las heridas sucias (79,1%), de miembros inferiores (45,8%), tipo fascitis necrotizante (41,6%). El grupo experimental, según la localización, experimentó una reducción global del tiempo de cicatrización (28% granulación y 24% epitelización), siendo las de región abdominal con mayor reducción de tiempo (Granulación: 17días) (Epitelización: 26días); según el tipo, también se observó una reducción global del tiempo de cicatrización (27% granulación y 26% epitelización); las gangrenas de Fournier presentaron mayor declive en tiempo (Granulación: 17,6días) (Epitelización: 27,9días) Conclusión: Menor costo económico, no reacciones adversas, y una curación significativa, fueron los beneficios asociados al uso del Alumbre de Potasio(AU)

Reducing the healing time of chronic wounds (HC), with feasible alternatives, accessible and cheap materials, constitutes a strategy to reduce the chronicity of these injuries considered a public health problem. Objective: Determining the healing effect of 2% Potassium Alum on chronic wounds. Methods: Descriptive, prospective, longitudinal, experimental, clinical trial type study was carried out, The population consisted of 48 patients, the entire sample being (occurrence: 100% / confidence: 99%), stratifying into two groups: control (20) with placebo treatment and experimental (28) treated with Potassium Alum. All wounds received bed preparation, with surgical debridement. Results: Systemic factors that affected healing were age ≥ 65 years (77%), hypertension (56.2%), sedentary lifestyle (95.8 %) and local edema (35.4%); and as protective factors, the male gender (72.9%), normal nutritional status (83.3%) and antibiotic and analgesic coverage (100%). Dirty wounds (79.1%), lower limbs (45.8%), necrotizing fasciitis type (41.6%) predominated. The experimental group, depending on the location, experienced a global reduction in healing time (28% granulation and 24% epithelization), with the abdominal region showing the greatest reduction in time (Granulation: 17 days) (Epithelialization: 26 days) depending on the type, an overall reduction in healing time was also observed (27% granulation and 26% epithelialization); Fournier's gangrene presented a greater decline in time (Granulation: 17.6 days) (Epithelialization: 27.9 days). Conclusion: Lower economic cost, no adverse reactions, and significant healing, were the benefits associated with the use of Potassium Alum(AU)

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La mucormicosis, es una patología de baja preva- lencia, rápidamente progresiva y de alta mortalidad que engloba un amplio espectro de infecciones del tipo opor- tunistas, causada por hongos de la familia Mucoraceae, Lichtheimiaceae, Thamnidiaceae, Cunninghamellaceae, Syncephalastraceae y Radiomycetaeae. Actualmente es la tercera causa de infección fúngica invasiva, posterior a la candidiasis y aspergilosos, siendo su presentación clínica más frecuente la rinocerebral de origen paranasal, cuyo síntoma característico es la rinosinusitis aguda bacteriana con proyección a los dientes antrales, de rápido avance y fatalidad. En esta revisión se emplearon resultados extraídos ma- nualmente de artículos indexados en las bases de datos MED- LINE y EBSCO a raíz de la búsqueda de los términos mu- cormycosis, oral surgery y patient care management con el objetivo de entregar una visión actualizada de la literatura, respecto al diagnóstico y tratamiento de la mucormicosis de cabeza y cuello (AU)

Mucormycosis is a low-prevalence, rapidly progres- sive and high-mortality pathology that encompasses a wide spectrum of opportunistic infections caused by fungi of the Mucoraceae, Lichtheimiaceae, Thamnidiaceae, Cunningha- mellaceae, Syncephalastraceae, and Radiomycetaeae. It is currently the third cause of invasive fungal infection, after candidiasis and aspergillosis, with its most frequent clinical presentation being rhinocerebral of paranasal origin, whose characteristic symptom is acute bacterial rhinosinusitis with projection to the antral teeth, with rapid progression and fatality. In this review, manually extracted results from articles indexed in the MEDLINE and EBSCO databases were used following the search for the terms mucormycosis, oral sur- gery and patient care management with the aim of providing an updated view of the literature regarding the diagnosis and treatment of mucormycosis of the head and neck

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PURPOSE: The angiogenic, osteogenic and anti-inflammatory activity of latex of Hancornia speciosa has been evidenced and indicates pharmacological potential with great applicability in the health area, especially in the wound healing process. The present work aimed to compare the effects of the H. speciosa macroporous latex biomembrane with saline on wound healing. METHODS: Forty-three Wistar rats were submitted to excisional wound induction procedure and divided into groups according to treatment: saline (G1), and macroporous biomembrane (G2). The animals were euthanized at three, seven, 14, and 21 days after injury induction (DAI), and three animals were used for the debridement test. Morphometric, macroscopic, and microscopic analyses of general pathological processes were performed. RESULTS: The macroporous biomembrane minimized necrosis and inflammation during the inflammatory and proliferative phases of the healing process, confirmed by the lower intensity of the crust and the debridement effect. In addition, the wounds treated with the macroporous biomembrane presented greater contraction rates in all the experimental periods analyzed. CONCLUSIONS: The macroporous biomembrane presents angiogenic, anti-inflammatory and debridement effects, contributing to the healing process, and can be considered a potentially promising new biomaterial to be used as a dressing.

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La fascitis necrosante es una enfermedad rara y potencialmente mortal, que se produce por una infección grave que se disemina desde las fascias superficiales destruyendo el tejido celular subcutáneo y la piel suprayacente. Las formas perioculares de la enfermedad son aún más raras y pueden tener graves consecuencias para el paciente. El objetivo de este estudio fue contrastar los hallazgos clínicos y los resultados terapéuticos en una serie de cuatro casos diagnosticados en el Centro Oftalmológico de Holguín en el curso de cinco años. Entre 2017 y 2022 se diagnosticaron cuatro pacientes con formas perioculares de fascitis necrosante en el Centro Oftalmológico de Holguín. Dos pacientes tuvieron antecedentes de trauma menor. El dolor predominó entre los síntomas locales. Se identificaron dos patrones de lesiones: bilateral con ulceración y afectación de la región palpebral superior y unilateral con extensión en ambos párpados y apariencia oscura de la piel. Los pacientes evolucionaron a la gravedad con deterioro del estado general. El desbridamiento del tejido necrótico y el tratamiento con antibióticos de amplio espectro permitieron detener el progreso de la enfermedad, aunque quedaron secuelas anatómicas y funcionales. Un paciente falleció como consecuencia de una leucemia diagnosticada durante su ingreso. El reconocimiento temprano de la fascitis necrosante periocular y su inmediato tratamiento es indispensable para garantizar resultados óptimos y la supervivencia del paciente. Las formas perioculares pueden tener apariencia clínica diversa, lo que debe ser tenido en cuenta ante la sospecha de este cuadro, sobre todo por la similitud inicial con la celulitis preseptal(AU)

Necrotizing fasciitis is a rare and potentially fatal disease caused by a severe infection that spreads from the superficial fasciae destroying the subcutaneous cellular tissue and overlying skin. Periocular forms of the disease are even rarer and can have serious consequences for the patient. The aim of this study was to contrast clinical findings and therapeutic outcomes in a series of four cases diagnosed at the Holguin Ophthalmology Center over the course of five years. Between 2017 and 2022, four patients with periocular forms of necrotizing fasciitis were diagnosed at the Holguín Ophthalmologic Center. Two patients had a history of minor trauma. Pain predominated among the local symptoms. Two patterns of lesions were identified: bilateral with ulceration and involvement of the upper palpebral region and unilateral with extension in both eyelids and dark appearance of the skin. Patients progressed to severity with deterioration of general condition. Debridement of necrotic tissue and treatment with broad-spectrum antibiotics halted disease progression, although anatomical and functional sequelae remained. One patient died as a result of leukemia diagnosed during his admission. Early recognition of periocular necrotizing fasciitis and its immediate treatment is essential to ensure optimal outcome and patient survival. Periocular forms can have different clinical appearances, which should be taken into account when suspecting this condition, especially due to the initial similarity with preseptal cellulitis(AU)

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SUMMARY: Cervical necrotizing fasciitis (NF) is a rare complication of oral cavity infection with high morbi-mortality. Given its low prevalence, adequately reporting cases of NF, its therapeutic management, and associated morphofunctional modifications to the clinical and scientific community is pivotal. To that end, we herein describe a case of cervical NF in a 60-year-old patient with comorbidities and patient presented large, painful cervical swelling associated with a necrotic ulcer lesion in the anterior neck region. Intraoral examination indicated a periodontal abscess in the right mandibular area, while computed tomography indicated the lesion's extension from the right mandibular to the submandibular region. Following empirical intravenous antibiotic treatment, a broad surgical debridement was performed, and the foci of oral infection were removed. Debridement revealed communication between deep and superficial anatomical regions in the submandibular area, where we subsequently placed a Penrose drain. Biopsies showing acute inflammatory infiltrate associated with necrotic and hemorrhagic regions confirmed the diagnosis of NF. When an antibiogram revealed resistance to the empirical treatment, the antibiotic scheme was replaced with an adequate alternative. After a second debridement, we closed the defect with fascio-mucocutaneous advancement flaps with a lateral base while maintaining suction drainage. Having reacted positively, the patient was discharged 10 days after the operation. Despite an extensive morphofunctional change generated in the treated area, the patient showed no difficulties with breathing, phonation, swallowing, or mobilizing the area during control sessions. Altogether, this report contributes to the highly limited literature describing morphological aspects that can facilitate or delay the spread of infection or the morphofunctional disorders associated with the size and depth of surgical interventions for cervical NF, information that is relevant for the comprehensive, long-term prognosis of the treatment of NF.

La fascitis necrosante (FN) cervical es una rara complicación de una infección proveniente de la cavidad bucal asociada a una alta morbimortalidad. Por lo anterior, es fundamental informar a la comunidad clínica y científica los casos de FN, su manejo terapéutico y las modificaciones morfofuncionales asociadas. Se describe un caso de FN cervical en una paciente de 60 años quien presentó una gran tumefacción dolorosa asociada a una lesión ulcerosa necrótica en la región anterior del cuello. El examen intraoral mostró un absceso periodontal en el área mandibular derecha y la tomografía computarizada mostró la extensión de la lesión hacia la región submandibular. Tras el tratamiento antibiótico empírico, se realizó un desbridamiento quirúrgico extenso y se extirparon los focos de infección oral. El desbridamiento reveló comunicación entre las regiones anatómicas profundas y superficiales del área submandibular, donde se colocó un drenaje Penrose. Las biopsias mostraron un infiltrado inflamatorio agudo asociado con regiones necróticas y hemorrágicas, confirmando el diagnóstico de FN. El antibiograma reveló resistencia al tratamiento empírico, por lo que el esquema antibiótico se sustituyó. Tras un segundo desbridamiento, se cerró el defecto con colgajos de avance fascio-mucocutáneos de base lateral manteniendo drenaje aspirativo. El positivo progreso del paciente permitió su alta 10 días después. Aun cuando se generó una gran modificación morfofuncional en el área tratada, la paciente no presentó dificultades para respirar, hablar, deglutir o movilizar el área cervical intervenida durante las sesiones de control. Este informe contribuye a la limitada literatura que describe los aspectos morfológicos que pueden facilitar o retrasar la propagación de la FN y las consecuencias asociadas a los trastornos morfofuncionales provocadas por el tamaño y profundidad de las intervenciones quirúrgicas requeridas por la FN, información relevante para el pronóstico integral a largo plazo del tratamiento de la FN.

RESUMO

OBJECTIVE: This systematic review aimed to evaluate the effects of hyaluronic acid (HA) alone or in combination with any bone substitute for the treatment of intrabony defects (IBDs). MATERIAL AND METHODS: Six databases were searched up to April 2022 to find randomized clinical trials comparing the clinical effects of open flap debridement (OFD) + HA versus OFD alone (first group) or OFD + HA + bone substitutes versus OFD + bone substitutes (second group) in the treatment of IBDs with a follow-up of at least 3 months. Random effects models of mean differences were used to determine the clinical attachment level (CAL) gain, probing depth (PD) reduction, and radiographic bone fill (RBF). RESULTS: Of the 276 studies identified, 6 were included in the qualitative synthesis, and 5 in the meta-analyses. The meta-analyses in the first group showed a statistically significant differences for CAL gain (mean difference [MD]:1.00; 95% confidence interval [CI]:0.65 - 1.35; n = 2) and PD reduction (MD: 0.76; 95%CI: 0.34 - 1.17; n = 2) favoring HA + OFD at 6 months. However, in the second group, the meta-analyses did no show additional effect of HA in association with bone substitute was demonstrated for either CAL gain (MD: 0.57; 95%CI: - 0.30 - 1.43; n = 2) or PD reduction (MD: 1.05; 95%CI: - 0.38 - 2.47; n = 2) but did show significant differences for RBF (MD: 0.57; 95%CI: 0.15 - 0.99; n = 2) at 12 months. CONCLUSION: Compared with OFD alone, local application of HA in the treatment of IBDs provided a significant CAL gain and PD reduction at 6 months. However, its combination with bone substitutes showed no statistically significant differences at 12 months. CLINICAL RELEVANCE: The use of OFD + HA improves the CAL and PD in the treatment of IBDs compared to OFD only after 6 months of follow-up. These results are not maintained after 12 months.