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1.
Zootaxa ; 4858(1): zootaxa.4858.1.3, 2020 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-33056241

RESUMO

The hymenopteran parasitoids of pest species of Tephritidae in Brazil are best known by their most prominent species, members of Braconidae and Figitidae. Species in the less-studied families Diapriidae, Eulophidae and Pteromalidae, which are mostly pupal parasitoids, have been largely neglected and the literature on these groups is sparse and scattered. Therefore, their importance as natural enemies of fruit flies is likely underestimated. Here, we present a parasitoid-host-plant checklist of all diapriids, eulophids and pteromalids that parasitize fruit flies of economic importance in Brazil, namely Anastrepha species and Ceratitis capitata. A compilation of information of the seven species of these parasitoids occurring in Brazil-Coptera haywardi Loiácono and Trichopria anastrephae Lima (Diapriidae), Tetrastichus giffardianus Silvestri (Eulophidae), Pachycrepoideus vindemmiae (Rondani), Spalangia endius Walker, S. gemina Boucek and S. simplex Perkins (Pteromalidae)-including their taxonomic status, general biology, and potential as biocontrol agents, is presented. Additionally, we provide an illustrated key to species, aiming to highlight key morphological features and facilitate identification at species level, stimulating future research on these groups.


Assuntos
Himenópteros , Tephritidae , Animais , Brasil , Drosophila , Pupa
2.
Zootaxa ; 4810(3): zootaxa.4810.3.11, 2020 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-33055739

RESUMO

A checklist of the tephritid fauna (Diptera: Tephritidae) from Madeira archipelago is presented, including 17 known species and new distribution records for Porto Santo and Desertas Islands. An identification key to Madeira Tephritidae species with detailed illustrations is also provided. A new species of Oedosphenella Frey 1936, discovered in Madeira Island in 2004, is described as Oedosphenella bob sp. n. This genus is redefined and a key to the known species is provided. Comparative morphological analysis revealed that Bevismyia basuto Munro 1957 from Malawi should be included in the genus Oedosphenella. Therefore, we consider the genus name Oedosphenella Frey 1936 to be a senior synonym of Bevismyia Munro 1957 syn.n.


Assuntos
Tephritidae , Animais , Drosophila , Portugal
3.
Zootaxa ; 4809(1): zootaxa.4809.1.1, 2020 Jul 06.
Artigo em Inglês | MEDLINE | ID: mdl-33055946

RESUMO

Two African drosophilids have distinctive protarsal spines in both sexes: Drosophila spinipes Lamb, 1914 from the Seychelles and D. suma Burla, 1954 from the Ivory Coast. Both were later classified in the genus Hirtodrosophila Duda of the Zygothrica genus group, and suma synonymized under spinipes by Tsacas (2006). We resurrect suma from synonymy, define the spinipes species group, and add seven new species in the group from Africa and Madagascar: Drosophila cameroonensis n. sp., D. freidbergi n. sp., D. hypandrilata n. sp., D. jambiya n. sp., D. malagasy n. sp., D. nigrospinipes n. sp., and D. phalloserra n. sp. Another four species are reported but not described. Detailed morphology informs that these anthophilous flies do not belong to the Zygothrica genus group, and they are returned to the genus Drosophila (unplaced to subgenus), albeit primitive members with some very distinctive specialized features. All distribution records, published and new, are presented along with a key to all nine named species.


Assuntos
Agaricales , Drosophila , Animais , Feminino , Masculino
4.
Zootaxa ; 4809(1): zootaxa.4809.1.8, 2020 Jul 06.
Artigo em Inglês | MEDLINE | ID: mdl-33055953

RESUMO

This work presents new distribution records in Paraguay for 19 fruit fly species of the genus Anastrepha Schiner, including four new records for the country: A. alveatoides Blanchard, A. australis (Blanchard), A. obliqua (Macquart) and A. pastranai Blanchard. Additionally, an updated list of the 26 Anastrepha species present in Paraguay is provided, as well as illustrations (wings, aculeus tips) of the majority of species.


Assuntos
Tephritidae , Animais , Drosophila , Paraguai , Asas de Animais
5.
Zootaxa ; 4820(2): zootaxa.4820.2.9, 2020 Jul 28.
Artigo em Inglês | MEDLINE | ID: mdl-33056073

RESUMO

Despite the fact that many species are economically important agricultural pests, the fruit fly fauna of Ecuador is still relatively poorly known. To better understand this fauna and the distribution and host plants of the pest species, the Proyecto Nacional de Manejo de las Moscas de la Fruta of AGROCALIDAD has conducted trapping surveys in many parts of the country. Two new species of Anastrepha from Ecuador that were collected by this project are described and illustrated: A. quadripuncta Troya Norrbom and A. tinctobasis Troya Norrbom. A new species group, the morvasi group, is recognized for A. morvasi Zucchi and A. quadripuncta.


Assuntos
Tephritidae , Animais , Drosophila , Equador
6.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1088-1091, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018175

RESUMO

A unified framework for the analysis of fluorescence data taken by a two-photon imaging system is presented. As in the processing of blood-oxygen-level-dependent signals of functional magnetic resonance imaging, the acquired functional images have to be co-registered with a structural brain atlas before delineating the regions activated by a given stimulus. The voxels whose calcium traces are highly correlated with the predicted responses are demarcated without the need for subjective reasoning. Experimental data acquired while presenting olfactory stimuli are used to demonstrate the efficacy of the proposed schemes. The results indicate that the functional images of a Drosophila individual can be normalized into a standard stereotactic space, and the expected brain regions can be delineated adequately. This framework provides an opportunity to enable the development of a Drosophila functional connectome database.


Assuntos
Conectoma , Drosophila , Animais , Encéfalo/diagnóstico por imagem , Imageamento Tridimensional , Imagem por Ressonância Magnética
7.
Science ; 369(6508): 1163, 2020 09 04.
Artigo em Inglês | MEDLINE | ID: mdl-32883848
8.
PLoS Biol ; 18(9): e3000825, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32886690

RESUMO

Microbial dysbiosis in the upper digestive tract is linked to an increased risk of esophageal squamous cell carcinoma (ESCC). Overabundance of Porphyromonas gingivalis is associated with shorter survival of ESCC patients. We investigated the molecular mechanisms driving aggressive progression of ESCC by P. gingivalis. Intracellular invasion of P. gingivalis potentiated proliferation, migration, invasion, and metastasis abilities of ESCC cells via transforming growth factor-ß (TGFß)-dependent Drosophila mothers against decapentaplegic homologs (Smads)/Yes-associated protein (YAP)/Transcriptional coactivator with PDZ-binding motif (TAZ) activation. Smads/YAP/TAZ/TEA domain transcription factor1 (TEAD1) complex formation was essential to initiate downstream target gene expression, inducing an epithelial-mesenchymal transition (EMT) and stemness features. Furthermore, P. gingivalis augmented secretion and bioactivity of TGFß through glycoprotein A repetitions predominant (GARP) up-regulation. Accordingly, disruption of either the GARP/TGFß axis or its activated Smads/YAP/TAZ complex abrogated the tumor-promoting role of P. gingivalis. P. gingivalis signature genes based on its activated effector molecules can efficiently distinguish ESCC patients into low- and high-risk groups. Targeting P. gingivalis or its activated effectors may provide novel insights into clinical management of ESCC.


Assuntos
Infecções por Bacteroidaceae/complicações , Neoplasias Esofágicas/patologia , Carcinoma de Células Escamosas do Esôfago/patologia , Porphyromonas gingivalis/fisiologia , Fator de Crescimento Transformador beta/fisiologia , Proteínas Adaptadoras de Transdução de Sinal/metabolismo , Adulto , Idoso , Animais , Infecções por Bacteroidaceae/metabolismo , Infecções por Bacteroidaceae/mortalidade , Infecções por Bacteroidaceae/patologia , Células Cultivadas , Progressão da Doença , Drosophila , Neoplasias Esofágicas/metabolismo , Neoplasias Esofágicas/microbiologia , Neoplasias Esofágicas/mortalidade , Carcinoma de Células Escamosas do Esôfago/metabolismo , Carcinoma de Células Escamosas do Esôfago/microbiologia , Carcinoma de Células Escamosas do Esôfago/mortalidade , Feminino , Seguimentos , Células HCT116 , Humanos , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Nus , Pessoa de Meia-Idade , Transdução de Sinais/fisiologia , Proteínas Smad/metabolismo , Análise de Sobrevida , Fatores de Transcrição/metabolismo , Fator de Crescimento Transformador beta/metabolismo
9.
Pestic Biochem Physiol ; 170: 104680, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32980059

RESUMO

The progression of neurodegenerative disease is very complex biological process and the molecular crosstalk of inflammatory cytokines during neurodegeneration is associated with multiple cascade signalling. Few evidences suggest that environmental toxin, Paraquat (PQ) administration activates the microglia and intensify the release of proinflamatory cytokines during progression of Parkinson''s disease (PD) but the proper aetiology remained unknown. However, the fundamental role of anti-inflammatory molecule Decapentaplegic (Dpp), homologue of the secreted mammalian Transforming growth factor-ß (TGF-ß) signalling molecule during neurodegeneration of invertebrate fly model is yet to establish. To elucidate the molecular processes during early stage of Parkinson's disease, we observed neuro-toxin plays a determining role in the increased vulnerability to a particular PQ exposure that is attended by decreased lifespan, severe locomotor deficits, and more loss of dopaminergic (DA) neuron in PQ-treated Dpp deficient fly than wild type (WT). Simultaneously, activated microglia induced the inflammatory response with the release of pro-inflammatory and anti-inflammatory cytokine in Drosophila during neurodegeneration. Moreover, neuro-toxin exposure altered the expression of innate immune genes in both WT and mutant fly compared to the respective PQ-treated flies. Interestingly, PQ exposure reduced the expression of innate immune genes in mutant fly compared to WT. It may indicate that PQ exposure had broken down the immune defence response in mutant fly than WT whereas, without PQ exposure the innate immune tolerance level was higher in fly with reduced Dpp expression than WT. Thus, we observed the conserve anti-inflammatory factor TGF-ß may exhibit a crucial defensive role during inflammation mediated neurodegeneration in invertebrate Drosophila melanogaster.


Assuntos
Proteínas de Drosophila/genética , Doenças Neurodegenerativas/induzido quimicamente , Doenças Neurodegenerativas/genética , Animais , Modelos Animais de Doenças , Drosophila , Drosophila melanogaster/genética , Imunidade Inata/genética , Inflamação/induzido quimicamente , Inflamação/genética , Neuroglia , Paraquat/toxicidade
10.
BMC Bioinformatics ; 21(Suppl 13): 385, 2020 Sep 17.
Artigo em Inglês | MEDLINE | ID: mdl-32938373

RESUMO

BACKGROUND: Network alignment is an efficient computational framework in the prediction of protein function and phylogenetic relationships in systems biology. However, most of existing alignment methods focus on aligning PPIs based on static network model, which are actually dynamic in real-world systems. The dynamic characteristic of PPI networks is essential for understanding the evolution and regulation mechanism at the molecular level and there is still much room to improve the alignment quality in dynamic networks. RESULTS: In this paper, we proposed a novel alignment algorithm, Twadn, to align dynamic PPI networks based on a strategy of time warping. We compare Twadn with the existing dynamic network alignment algorithm DynaMAGNA++ and DynaWAVE and use area under the receiver operating characteristic curve and area under the precision-recall curve as evaluation indicators. The experimental results show that Twadn is superior to DynaMAGNA++ and DynaWAVE. In addition, we use protein interaction network of Drosophila to compare Twadn and the static network alignment algorithm NetCoffee2 and experimental results show that Twadn is able to capture timing information compared to NetCoffee2. CONCLUSIONS: Twadn is a versatile and efficient alignment tool that can be applied to dynamic network. Hopefully, its application can benefit the research community in the fields of molecular function and evolution.


Assuntos
Algoritmos , Biologia Computacional/métodos , Drosophila/metabolismo , Mapas de Interação de Proteínas/genética , Proteínas/metabolismo , Animais , Humanos
11.
Proc Natl Acad Sci U S A ; 117(37): 23085-23095, 2020 09 15.
Artigo em Inglês | MEDLINE | ID: mdl-32873637

RESUMO

Animals use active sensing to respond to sensory inputs and guide future motor decisions. In flight, flies generate a pattern of head and body movements to stabilize gaze. How the brain relays visual information to control head and body movements and how active head movements influence downstream motor control remains elusive. Using a control theoretic framework, we studied the optomotor gaze stabilization reflex in tethered flight and quantified how head movements stabilize visual motion and shape wing steering efforts in fruit flies (Drosophila). By shaping visual inputs, head movements increased the gain of wing steering responses and coordination between stimulus and wings, pointing to a tight coupling between head and wing movements. Head movements followed the visual stimulus in as little as 10 ms-a delay similar to the human vestibulo-ocular reflex-whereas wing steering responses lagged by more than 40 ms. This timing difference suggests a temporal order in the flow of visual information such that the head filters visual information eliciting downstream wing steering responses. Head fixation significantly decreased the mechanical power generated by the flight motor by reducing wingbeat frequency and overall thrust. By simulating an elementary motion detector array, we show that head movements shift the effective visual input dynamic range onto the sensitivity optimum of the motion vision pathway. Taken together, our results reveal a transformative influence of active vision on flight motor responses in flies. Our work provides a framework for understanding how to coordinate moving sensors on a moving body.


Assuntos
Drosophila/fisiologia , Voo Animal/fisiologia , Visão Ocular/fisiologia , Vias Visuais/fisiologia , Animais , Fenômenos Biomecânicos/fisiologia , Movimentos da Cabeça/fisiologia , Mecanorreceptores/fisiologia , Movimento (Física) , Asas de Animais/fisiologia
12.
Nat Commun ; 11(1): 4060, 2020 08 13.
Artigo em Inglês | MEDLINE | ID: mdl-32792512

RESUMO

Chromatin modifiers affect spatiotemporal gene expression programs that underlie organismal development. The Polycomb repressive complex 2 (PRC2) is a crucial chromatin modifier in executing neurodevelopmental programs. Here, we find that PRC2 interacts with the nucleic acid-binding protein Ybx1. In the mouse embryo in vivo, Ybx1 is required for forebrain specification and restricting mid-hindbrain growth. In neural progenitor cells (NPCs), Ybx1 controls self-renewal and neuronal differentiation. Mechanistically, Ybx1 highly overlaps PRC2 binding genome-wide, controls PRC2 distribution, and inhibits H3K27me3 levels. These functions are consistent with Ybx1-mediated promotion of genes involved in forebrain specification, cell proliferation, or neuronal differentiation. In Ybx1-knockout NPCs, H3K27me3 reduction by PRC2 enzymatic inhibitor or genetic depletion partially rescues gene expression and NPC functions. Our findings suggest that Ybx1 fine-tunes PRC2 activities to regulate spatiotemporal gene expression in embryonic neural development and uncover a crucial epigenetic mechanism balancing forebrain-hindbrain lineages and self-renewal-differentiation choices in NPCs.


Assuntos
Encéfalo/embriologia , Encéfalo/metabolismo , Histona-Lisina N-Metiltransferase/metabolismo , Fatores de Transcrição/metabolismo , Animais , Western Blotting , Diferenciação Celular/genética , Diferenciação Celular/fisiologia , Proliferação de Células/genética , Proliferação de Células/fisiologia , Células Cultivadas , Imunoprecipitação da Cromatina , Drosophila , Epigênese Genética/genética , Citometria de Fluxo , Imunofluorescência , Histona-Lisina N-Metiltransferase/genética , Imunoprecipitação , Camundongos , Camundongos Knockout , Processamento de Proteína Pós-Traducional/genética , Processamento de Proteína Pós-Traducional/fisiologia , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Fatores de Transcrição/genética
13.
Nat Commun ; 11(1): 4182, 2020 08 21.
Artigo em Inglês | MEDLINE | ID: mdl-32826882

RESUMO

Living in a group allows individuals to decrease their defenses, enabling other beneficial behaviors such as foraging. The detection of a threat through social cues is widely reported, however, the safety cues that guide animals to break away from a defensive behavior and resume alternate activities remain elusive. Here we show that fruit flies display a graded decrease in freezing behavior, triggered by an inescapable threat, with increasing group sizes. Furthermore, flies use the cessation of movement of other flies as a cue of threat and its resumption as a cue of safety. Finally, we find that lobula columnar neurons, LC11, mediate the propensity for freezing flies to resume moving in response to the movement of others. By identifying visual motion cues, and the neurons involved in their processing, as the basis of a social safety cue this study brings new insights into the neuronal basis of safety in numbers.


Assuntos
Comportamento Animal , Drosophila/fisiologia , Neurônios/fisiologia , Segurança , Comportamento Social , Animais , Sinais (Psicologia) , Feminino , Congelamento
14.
PLoS Comput Biol ; 16(8): e1008049, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32822341

RESUMO

Tissue morphogenesis relies on repeated use of dynamic behaviors at the levels of intracellular structures, individual cells, and cell groups. Rapidly accumulating live imaging datasets make it increasingly important to formalize and automate the task of mapping recurrent dynamic behaviors (motifs), as it is done in speech recognition and other data mining applications. Here, we present a "template-based search" approach for accurate mapping of sub- to multi-cellular morphogenetic motifs using a time series data mining framework. We formulated the task of motif mapping as a subsequence matching problem and solved it using dynamic time warping, while relying on high throughput graph-theoretic algorithms for efficient exploration of the search space. This formulation allows our algorithm to accurately identify the complete duration of each instance and automatically label different stages throughout its progress, such as cell cycle phases during cell division. To illustrate our approach, we mapped cell intercalations during germband extension in the early Drosophila embryo. Our framework enabled statistical analysis of intercalary cell behaviors in wild-type and mutant embryos, comparison of temporal dynamics in contracting and growing junctions in different genotypes, and the identification of a novel mode of iterative cell intercalation. Our formulation of tissue morphogenesis using time series opens new avenues for systematic decomposition of tissue morphogenesis.


Assuntos
Biologia Computacional/métodos , Processamento de Imagem Assistida por Computador/métodos , Morfogênese/fisiologia , Algoritmos , Animais , Divisão Celular/fisiologia , Mineração de Dados/métodos , Drosophila/citologia , Drosophila/embriologia , Embrião não Mamífero/citologia , Embrião não Mamífero/embriologia , Feminino , Masculino , Microscopia Confocal , Fatores de Tempo
15.
Phys Rev Lett ; 125(7): 078003, 2020 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-32857587

RESUMO

Determining the positions of lattice defects on bounded elastic surfaces with Gaussian curvature is a nontrivial task of mechanical energy optimization. We introduce a simple way to predict the onset of disclination disorder from the shape of the surface. The criterion fixes the value of a weighted integral Gaussian curvature to a universal constant and proves accurate across a great variety of shapes. It provides improved understanding of the limitations to crystalline order in many natural and engineering contexts, such as the assembly of viral capsids.


Assuntos
Capsídeo/química , Modelos Teóricos , RNA/química , Animais , Proteínas do Capsídeo/química , Drosophila , Elasticidade , HIV/química , Vírus da SARS/química , Propriedades de Superfície , Termodinâmica , Thermoproteus
16.
PLoS Comput Biol ; 16(8): e1008105, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32817654

RESUMO

Epithelial sheets define organ architecture during development. Here, we employed an iterative multiscale computational modeling and quantitative experimental approach to decouple direct and indirect effects of actomyosin-generated forces, nuclear positioning, extracellular matrix, and cell-cell adhesion in shaping Drosophila wing imaginal discs. Basally generated actomyosin forces generate epithelial bending of the wing disc pouch. Surprisingly, acute pharmacological inhibition of ROCK-driven actomyosin contractility does not impact the maintenance of tissue height or curved shape. Computational simulations show that ECM tautness provides only a minor contribution to modulating tissue shape. Instead, passive ECM pre-strain serves to maintain the shape independent from actomyosin contractility. These results provide general insight into how the subcellular forces are generated and maintained within individual cells to induce tissue curvature. Thus, the results suggest an important design principle of separable contributions from ECM prestrain and actomyosin tension during epithelial organogenesis and homeostasis.


Assuntos
Actomiosina/metabolismo , Epitélio/anatomia & histologia , Matriz Extracelular/metabolismo , Animais , Drosophila/anatomia & histologia , Drosophila/embriologia , Drosophila/metabolismo , Epitélio/metabolismo , Fosforilação , Asas de Animais/anatomia & histologia , Asas de Animais/embriologia , Asas de Animais/metabolismo
17.
Proc Biol Sci ; 287(1932): 20201286, 2020 08 12.
Artigo em Inglês | MEDLINE | ID: mdl-32752988

RESUMO

Spermatozoa are the most morphologically diverse cell type, leading to the widespread assumption that they evolve rapidly. However, there is no direct evidence that sperm evolve faster than other male traits. Such a test requires comparing male traits that operate in the same selective environment, ideally produced from the same tissue, yet vary in function. Here, we examine rates of phenotypic evolution in sperm morphology using two insect groups where males produce fertile and non-fertile sperm types (Drosophila species from the obscura group and a subset of Lepidoptera species), where these constraints are solved. Moreover, in Drosophila we test the relationship between rates of sperm evolution and the link with the putative selective pressures of fertilization function and postcopulatory sexual selection exerted by female reproductive organs. We find repeated evolutionary patterns across these insect groups-lengths of fertile sperm evolve faster than non-fertile sperm. In Drosophila, fertile sperm length evolved faster than body size, but at the same rate as female reproductive organ length. We also compare rates of evolution of different sperm components, showing that head length evolves faster in fertile sperm while flagellum length evolves faster in non-fertile sperm. Our study provides direct evidence that sperm length evolves more rapidly in fertile sperm, probably because of their functional role in securing male fertility and in response to selection imposed by female reproductive organs.


Assuntos
Evolução Biológica , Espermatozoides/fisiologia , Animais , Drosophila/fisiologia , Feminino , Fertilização , Masculino
18.
Proc Natl Acad Sci U S A ; 117(32): 19544-19555, 2020 08 11.
Artigo em Inglês | MEDLINE | ID: mdl-32747566

RESUMO

Corresponding attributes of neural development and function suggest arthropod and vertebrate brains may have an evolutionarily conserved organization. However, the underlying mechanisms have remained elusive. Here, we identify a gene regulatory and character identity network defining the deutocerebral-tritocerebral boundary (DTB) in Drosophila This network comprises genes homologous to those directing midbrain-hindbrain boundary (MHB) formation in vertebrates and their closest chordate relatives. Genetic tracing reveals that the embryonic DTB gives rise to adult midbrain circuits that in flies control auditory and vestibular information processing and motor coordination, as do MHB-derived circuits in vertebrates. DTB-specific gene expression and function are directed by cis-regulatory elements of developmental control genes that include homologs of mammalian Zinc finger of the cerebellum and Purkinje cell protein 4 Drosophila DTB-specific cis-regulatory elements correspond to regulatory sequences of human ENGRAILED-2, PAX-2, and DACHSHUND-1 that direct MHB-specific expression in the embryonic mouse brain. We show that cis-regulatory elements and the gene networks they regulate direct the formation and function of midbrain circuits for balance and motor coordination in insects and mammals. Regulatory mechanisms mediating the genetic specification of cephalic neural circuits in arthropods correspond to those in chordates, thereby implying their origin before the divergence of deuterostomes and ecdysozoans.


Assuntos
Evolução Molecular , Redes Reguladoras de Genes , Mesencéfalo/fisiologia , Animais , Comportamento Animal , Encéfalo/embriologia , Encéfalo/metabolismo , Encéfalo/fisiologia , Drosophila , Fator 8 de Crescimento de Fibroblasto/genética , Fator 8 de Crescimento de Fibroblasto/metabolismo , Regulação da Expressão Gênica no Desenvolvimento , Humanos , Mesencéfalo/embriologia , Mesencéfalo/metabolismo , Camundongos , Proteínas do Tecido Nervoso/genética , Proteínas do Tecido Nervoso/metabolismo , Vias Neurais , Fatores de Transcrição Box Pareados/genética , Fatores de Transcrição Box Pareados/metabolismo , Sequências Reguladoras de Ácido Nucleico , Rombencéfalo/embriologia , Rombencéfalo/metabolismo , Rombencéfalo/fisiologia , Transdução de Sinais
20.
Proc Biol Sci ; 287(1933): 20201309, 2020 08 26.
Artigo em Inglês | MEDLINE | ID: mdl-32842926

RESUMO

The transient receptor potential superfamily of ion channels (TRP channels) is widely recognized for the roles its members play in sensory nervous systems. However, the incredible diversity within the TRP superfamily, and the wide range of sensory capacities found therein, has also allowed TRP channels to function beyond sensing an organism's external environment, and TRP channels have thus become broadly critical to (at least) animal life. TRP channels were originally discovered in Drosophila and have since been broadly studied in animals; however, thanks to a boom in genomic and transcriptomic data, we now know that TRP channels are present in the genomes of a variety of creatures, including green algae, fungi, choanoflagellates and a number of other eukaryotes. As a result, the organization of the TRP superfamily has changed radically from its original description. Moreover, modern comprehensive phylogenetic analyses have brought to light the vertebrate-centricity of much of the TRP literature; much of the nomenclature has been grounded in vertebrate TRP subfamilies, resulting in a glossing over of TRP channels in other taxa. Here, we provide a comprehensive review of the function, structure and evolutionary history of TRP channels, and put forth a more complete set of non-vertebrate-centric TRP family, subfamily and other subgroup nomenclature.


Assuntos
Evolução Molecular , Canais de Receptores Transientes de Potencial , Animais , Drosophila , Filogenia
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