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3.
Yakugaku Zasshi ; 144(6): 685-690, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38825477

RESUMO

Docetaxel (DTX) is a key drug used in perioperative chemotherapy for breast cancer. Edema is a known adverse effect of DTX, but its effect on health-related QOL (HRQOL) is unclear. In this study, we evaluated the effects of edema caused by administration of DTX on HRQOL in patients with early-stage breast cancer. We prospectively investigated patients diagnosed with early-stage breast cancer (stage I-III) who received 4 cycles of DTX as preoperative or postoperative chemotherapy between September 2021 and December 2022 at Yamanashi Prefectural Central Hospital. The circumference of each extremity was measured at each administration of DTX, and limb edema was evaluated by Common Terminology Criteria for Adverse Events version 5.0. HRQOL was evaluated using SF-12 version 2, which has a range of 0-100 (national standard, 50), and compared between the presence and absence of grade 2 or higher edema and between before and after administration of DTX. Twenty patients met the eligibility criteria and were included in the study. There was no difference in the HRQOL score according to whether grade 2 limb edema was present. The median HRQOL summary scores before and after administration of DTX were 51.1 and 50.8 (p=0.763), respectively, for mental health, 52.6 and 49.4 (p=0.005) for physical health, and 38.9 and 37.5 (p=1.000) for role/social health. We found no direct effect of DTX-induced limb edema on HRQOL in patients with early-stage breast cancer. However, HRQOL summary scores indicated that administration of DTX reduced physical health in these patients.


Assuntos
Neoplasias da Mama , Docetaxel , Edema , Qualidade de Vida , Humanos , Docetaxel/efeitos adversos , Docetaxel/administração & dosagem , Neoplasias da Mama/tratamento farmacológico , Feminino , Estudos Prospectivos , Pessoa de Meia-Idade , Edema/induzido quimicamente , Edema/etiologia , Idoso , Estadiamento de Neoplasias , Adulto , Extremidades , Antineoplásicos/efeitos adversos , Assistência Perioperatória
5.
Curr Rheumatol Rev ; 20(3): 332-336, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38807471

RESUMO

INTRODUCTION: Synovial hemangioma is a benign soft-tissue tumor of vascular origin. Hemangioma only accounts for 1% of all bone lesions and is mostly an incidental finding among the primary skeleton tumors. A delay in diagnosis results in joint degeneration and osteoarthritic damage because of infiltrating tumor growth. CASE PRESENTATION: We presented a rare case of an intra-articular synovial hemangioma in a 13- year-old pediatric patient who was asymptomatic for 5 years. She attended orthopedics OPD at AIIMS, Mangalagiri. Surgical excision of the mass and partial synovectomy was done. Synovial hemangioma came out to be the diagnosis following a histologic study. CONCLUSION: As radiography has limited diagnostic ability, synovial hemangiomas are difficult and challenging to identify on an outpatient basis. Histological examination and magnetic resonance imaging are extremely helpful. To minimize the hemarthrosis risks, early complete excision can be used as the best treatment modality.


Assuntos
Hemangioma , Articulação do Joelho , Membrana Sinovial , Humanos , Feminino , Adolescente , Hemangioma/complicações , Hemangioma/diagnóstico por imagem , Hemangioma/cirurgia , Articulação do Joelho/diagnóstico por imagem , Articulação do Joelho/patologia , Membrana Sinovial/patologia , Membrana Sinovial/diagnóstico por imagem , Artralgia/etiologia , Sinovectomia , Neoplasias de Tecidos Moles/complicações , Neoplasias de Tecidos Moles/diagnóstico por imagem , Imageamento por Ressonância Magnética , Edema/etiologia , Edema/diagnóstico por imagem
6.
BMJ Case Rep ; 17(5)2024 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-38749521

RESUMO

A woman in her 70s presented with anasarca and exertional dyspnoea. Investigation showed severe hypoalbuminaemia with no urinary or gastrointestinal protein losses. CT thorax reported lung consolidations, and transbronchial lung biopsy demonstrated organising pneumonia. Autoimmune myositis serology was positive for anti-Jo-1, anti-Ro-52, and anti-PM/Scl-100 antibodies. She was diagnosed with anti-synthetase syndrome with organising pneumonia. She was treated with oral prednisolone and oral mycophenolate mofetil with a good clinical response.


Assuntos
Edema , Miosite , Humanos , Feminino , Miosite/tratamento farmacológico , Miosite/diagnóstico , Miosite/complicações , Miosite/imunologia , Idoso , Edema/tratamento farmacológico , Edema/etiologia , Prednisolona/uso terapêutico , Prednisolona/administração & dosagem , Ácido Micofenólico/uso terapêutico , Tomografia Computadorizada por Raios X , Pneumonia/tratamento farmacológico , Pneumonia/diagnóstico , Dispneia/etiologia
7.
BMJ Case Rep ; 17(5)2024 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-38702071

RESUMO

We describe an early adolescent male who was diagnosed with vascular malformation associated with unilateral limb overgrowth based on the clinical findings of a persistent port-wine stain since birth and gradually progressing right lower limb oedema since early childhood. Clinicians should keep in mind to clinically evaluate such malformations in detail, as well as contemplate genetic testing in patients presenting with a large port-wine stain at birth, particularly if well demarcated and lateral in a lower extremity.


Assuntos
Edema , Extremidade Inferior , Mancha Vinho do Porto , Humanos , Masculino , Adolescente , Edema/etiologia , Mancha Vinho do Porto/diagnóstico
8.
J Evid Based Dent Pract ; 24(2): 101983, 2024 06.
Artigo em Inglês | MEDLINE | ID: mdl-38821660

RESUMO

OBJECTIVES: The extraction of third molars is one of the most performed surgical procedures in oral and maxillofacial surgery. Pain, oedema, and trismus are the most frequently complications related in the surgical postoperative period. The literature has indicated PBM as a potential adjuvant method to reduce these complications. The aim of this review and meta-analysis is evaluate the PBM, as an optimal method to improve patient experience and minimize postoperative morbidity. Additionally, we seek to determine which wavelength, site, and frequency of application are most effective. METHODS: This review was registered in PROSPERO (CRD42023429966) and followed PRISMA guidelines. The search was carried out in the main databases, PubMed/MEDLINE, Cochrane Library, Embase, Scopus, and Lilacs, including reviews in the most important journals in the area of oral surgery and laser applied to oral surgery. In addition, all article references and also gray literature were reviewed. After the studies selection, the relevant data was collected. All the studies were randomized controlled trials and the patients were allocated into two groups: active PBM and inactive PBM. The statistical analysis was carried out using Stata v.16, and the methodological quality and risk of bias were assessed by the Jadad scale and RoB 2.0, respectively. RESULTS: Where included 22 studies and 989 subjects, to all with a minimum follow-up of 7 days. Pain and oedema showed statistically significant results in favor to the active PBM group. Especially when laser applied in infrared mode, for pain and oedema at 48 h, MD = -1.80 (CI95% -2.88, -0.72) I²â€¯= 92.13% and MD = -1.45 (CI95% -2.42, -0.48) I²â€¯= 65.01%, respectively. The same is not true for trismus at 48 h, MD = 0.07 (CI95% -0.06, 0.21) I²â€¯= 3.26%. The meta-analysis also presented results in respect of laser site of application and number of PBM sessions. CONCLUSIONS: PBM with infrared laser, in a combination intraoral and extraoral application, in one session in the immediate postoperative period, has been shown to be effective to achieve the objectives of reducing pain and oedema after third molar extraction.


Assuntos
Edema , Terapia com Luz de Baixa Intensidade , Dente Serotino , Dor Pós-Operatória , Complicações Pós-Operatórias , Extração Dentária , Humanos , Dente Serotino/cirurgia , Terapia com Luz de Baixa Intensidade/métodos , Dor Pós-Operatória/prevenção & controle , Dor Pós-Operatória/etiologia , Edema/prevenção & controle , Edema/etiologia , Complicações Pós-Operatórias/prevenção & controle , Mandíbula/cirurgia , Trismo/prevenção & controle , Trismo/etiologia
11.
Medicina (Kaunas) ; 60(5)2024 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-38793003

RESUMO

Background and Objectives: Scrotal swelling or hydrocele is a rare complication of acute pancreatitis described in the literature. We present a case of penoscrotal swelling caused by the first attack of acute interstitial edematous alcohol-induced pancreatitis in a young male patient. Case report: A 22-year-old man was admitted to the emergency unit due to diarrhea and vomiting since morning which was followed by severe abdominal pain. Urgent abdominal multislice CT scan showed steatosis, pancreatic swelling and acute peripancreatic fluid collection (interstitial edematous pancreatitis). Also, scan showed fluid between small bowel loops and along the anterior renal fascia, while there was minimal amount of fluid in the Douglas space. There was no sign of penoscrotal swelling. On the second day of admission, the patient developed left scrotal swelling and mild pain without erythema. On the fourth day, a control CT scan showed progression to moderately severe pancreatitis (CT severity index 4). Dilated scrotal veins of the pampiniform venous plexus with an increased caliber of the testicular veins were present on both sides, from the scrotum to the level of the inguinal canal. Penoscrotal swelling was significantly reduced on discharge. Conclusions: Penoscrotal swelling is a rare complication or manifestation of acute inflammation of the pancreas. It is important to identify scrotal swelling caused by pancreatitis because in severe cases it can be related to possible infertility in the future.


Assuntos
Edema , Pancreatite , Escroto , Humanos , Masculino , Escroto/diagnóstico por imagem , Adulto Jovem , Edema/etiologia , Pancreatite/complicações , Pancreatite/etiologia , Doença Aguda , Adulto , Tomografia Computadorizada por Raios X
12.
J Coll Physicians Surg Pak ; 34(5): 610-613, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38720225

RESUMO

OBJECTIVE: To determine whether the presence of preoperative subchondral bone marrow oedema (SBME) is associated with inferior outcomes after lateral unicompartmental knee arthroplasty (LUKA). STUDY DESIGN: Descriptive study. Place and Duration of the Study: Department of Orthopaedic Surgery, Chongqing Orthopaedic Hospital of Traditional Chinese Medicine, Chongqing, China, from January 2019 to June 2022. METHODOLOGY: Data on patients treated with LUKA were obtained from the Medical Registry Database. Two groups were made based on the presence and absence of SBME on preoperative magnetic resonance imaging (MRI). The visual analogue scale (VAS), American Knee Society Scores (AKSS), and rate of patient satisfaction were compared between the two groups. RESULTS: A total of 20 patients treated with LUKA were reviewed. The SBME was present in 9 cases and absent in 11 cases. Patients with SBME had inferior scores at preoperative evaluation and at 1, 3, and 6 months postoperatively. However, there was no significant difference between the groups at the 12-month follow-up. Eight (88.9%) patients with SBME were satisfied with the LUKA surgery versus 9 (81.8%) patients without SBME, showing no significant differences between groups. CONCLUSION: Presence of preoperative SBME is associated with inferior functional outcomes after LUKA within six months of follow-up. KEY WORDS: Bone marrow, Oedema, Knee, Arthroplasty, Outcome, Patient satisfaction.


Assuntos
Artroplastia do Joelho , Doenças da Medula Óssea , Edema , Humanos , Artroplastia do Joelho/métodos , Masculino , Feminino , Pessoa de Meia-Idade , Edema/etiologia , Idoso , Doenças da Medula Óssea/cirurgia , Resultado do Tratamento , Imageamento por Ressonância Magnética , Satisfação do Paciente , Osteoartrite do Joelho/cirurgia , Estudos Retrospectivos , Articulação do Joelho/cirurgia , Período Pré-Operatório , Medula Óssea/patologia , China/epidemiologia
14.
South Med J ; 117(5): 241-244, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38701844

RESUMO

OBJECTIVES: Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is considered a rare inflammatory rheumatologic disorder that is seen primarily in older adult men. Patients present with arthralgias of large joints accompanied by painful pitting edema of the hands and feet. Few studies have reported the prevalence of metabolic syndromes, including diabetes mellitus and hyperlipidemia in these patients. METHODS: This case series reviewed 25 patients who were diagnosed as having RS3PE in a private outpatient clinic. RESULTS: Nearly half of the patients (48%) had diabetes mellitus, predominantly type 2, and more than half of the patients (60%) had hyperlipidemia. CONCLUSIONS: We believe that future case studies on RS3PE should include an assessment of various comorbidities that can be seen in patients with this autoinflammatory disorder. The increased availability of musculoskeletal ultrasound provides a potential area of study to differentiate this disorder from other inflammatory arthritis and improve reaching the correct diagnosis.


Assuntos
Edema , Sinovite , Humanos , Masculino , Sinovite/diagnóstico , Sinovite/epidemiologia , Sinovite/complicações , Edema/epidemiologia , Edema/diagnóstico , Edema/etiologia , Pessoa de Meia-Idade , Feminino , Idoso , Adulto , Hiperlipidemias/epidemiologia , Hiperlipidemias/complicações , Comorbidade , Estudos Retrospectivos , Idoso de 80 Anos ou mais , Diabetes Mellitus Tipo 2/complicações
15.
Exp Clin Transplant ; 22(3): 239-241, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38695593

RESUMO

Encapsulating peritoneal sclerosis is a rare but highly morbid disease process in patients with end-stage kidney disease on peritoneal dialysis. Surgical management has been described in patients with encapsulation of bowel causing obstruction. Here, we describe a case of surgical management in a patient following kidney transplant with medically refractory ascites and lower extremity edema.


Assuntos
Falência Renal Crônica , Transplante de Rim , Fibrose Peritoneal , Humanos , Transplante de Rim/efeitos adversos , Fibrose Peritoneal/cirurgia , Fibrose Peritoneal/etiologia , Fibrose Peritoneal/diagnóstico , Fibrose Peritoneal/diagnóstico por imagem , Falência Renal Crônica/cirurgia , Falência Renal Crônica/diagnóstico , Resultado do Tratamento , Ascite/etiologia , Ascite/cirurgia , Ascite/diagnóstico , Edema/etiologia , Edema/cirurgia , Masculino , Diálise Peritoneal/efeitos adversos , Feminino , Pessoa de Meia-Idade , Adulto
16.
Medicine (Baltimore) ; 103(19): e37995, 2024 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-38728522

RESUMO

Breast cancer-related lymphedema (BCRL) occurs usually on the affected side, and its cause and pathophysiology are well known. However, the cause of edema of the upper extremity on the unaffected side is barely known. It is often considered to be chemotherapy-induced general edema, and clinical evaluation is rarely performed in these patients. This study aimed to present the clinical characteristics of unilateral breast cancer patients with edema of upper extremity on the unaffected side, and to emphasize the importance of early diagnosis and medical interventions. This study retrospectively analyzed the medical records of unilateral breast cancer patients complaining edema of upper extremity on the unaffected side, from January 2020 to May 2021. Lymphoscintigraphy was used to assist in confirming the diagnosis of lymphedema, and Doppler ultrasonography or 3D computed tomography angiography were performed to differentiate vascular problems. Fourteen patients were enrolled in the study. Seven, 3, and 4 patients had edema of both upper extremities, edema of the upper extremity on the unaffected side only, and edema of all extremities, respectively. None of the 4 patients with edema of all extremities showed abnormal findings on examination. In patients with edema in the upper extremity on the unaffected side alone, lymphatic flow dysfunction was seen in 2 patients, and deep vein thrombosis (DVT) was diagnosed in 1. In patients with edema of both upper extremities, lymphatic flow dysfunction was seen in 2 patients, and DVT was diagnosed in 3. One patient had DVT and accompanying lymphatic flow dysfunction. Lymphedema and DVT were diagnosed in a number of patients with edema of the upper extremity on the unaffected side, and lymphedema can occur without direct injury to the lymphatic flow system. Therefore, clinicians should not overlook the fact that diseases that require early diagnosis and treatment can occur in patients with edema of the unaffected upper extremity.


Assuntos
Neoplasias da Mama , Extremidade Superior , Humanos , Feminino , Pessoa de Meia-Idade , Estudos Retrospectivos , Extremidade Superior/fisiopatologia , Neoplasias da Mama/complicações , Adulto , Idoso , Linfedema/etiologia , Linfedema/diagnóstico , Edema/etiologia , Linfocintigrafia/métodos , Ultrassonografia Doppler/métodos , Linfedema Relacionado a Câncer de Mama/diagnóstico , Angiografia por Tomografia Computadorizada/métodos
17.
Int J Oral Implantol (Berl) ; 17(2): 189-198, 2024 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-38801332

RESUMO

Maxillary sinus grafting is a predictable regenerative technique to facilitate maxillary posterior implant placement when there is insufficient vertical bone height inferior to the maxillary sinuses to allow placement of implants of adequate dimensions. It enables an increase in vertical bone height, which makes implant placement easier. Maxillary sinus mucosal membrane perforation is one of the most common intraoperative complications during maxillary sinus grafting and may result in extrusion of graft material into the sinus. When this occurs, the mucociliary function of the maxillary sinus may expel the extruded graft material through its natural ostium, though graft particles may remain in the sinus or possibly occlude the natural ostium. After grafting, transient maxillary sinus mucosal oedema may occur. A postoperative CBCT scan may reveal varying degrees of sinus opacification, namely partial, subtotal or total. Although it is always possible to identify graft material, which may enter the sinus as a result of membrane perforation that might not even be visible to the implantologist during the surgical procedure, it is challenging to assess whether sinus opacification is due to mucosal thickening or mucus accumulation. The aim of the present case series was to offer a pragmatic approach to managing asymptomatic patients whose CBCT scans demonstrated partial, subtotal or total maxillary sinus opacification with bone graft particles that seemed to have been extruded into the sinus.


Assuntos
Tomografia Computadorizada de Feixe Cônico , Seio Maxilar , Levantamento do Assoalho do Seio Maxilar , Humanos , Seio Maxilar/cirurgia , Seio Maxilar/diagnóstico por imagem , Levantamento do Assoalho do Seio Maxilar/efeitos adversos , Levantamento do Assoalho do Seio Maxilar/métodos , Pessoa de Meia-Idade , Masculino , Feminino , Mucosa Nasal/diagnóstico por imagem , Mucosa Nasal/patologia , Seguimentos , Edema/etiologia , Edema/diagnóstico por imagem , Edema/patologia , Transplante Ósseo/métodos , Transplante Ósseo/efeitos adversos , Complicações Pós-Operatórias/diagnóstico por imagem , Complicações Pós-Operatórias/etiologia , Idoso , Adulto , Implantação Dentária Endóssea/efeitos adversos , Implantação Dentária Endóssea/métodos
18.
J Craniofac Surg ; 35(4): 1219-1224, 2024 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-38722732

RESUMO

OBJECTIVE: This study aimed to evaluate the effects of sterile saline solution irrigation (lavage) performed after mandibular third molar extraction on postoperative complications, utilizing a split-mouth randomized clinical trial design. METHODS: Seventeen healthy participants requiring bilateral mandibular third molar extraction were enrolled in this single-center study. In each participant, one impacted third molar was designated as the experimental group and subjected to saline lavage at 4 °C. In contrast, the control group was the other impacted third molar, undergoing saline lavage at 25 °C. Various parameters, including postoperative pain, mouth opening, and facial swelling, were assessed using standardized measures and three-dimensional facial scanning at multiple time points. RESULTS: The average age of participants was 26.66 ± 4.1 years, with no postoperative complications observed in either group. The duration of surgery did not significantly differ between groups. Postoperative pain was significantly reduced in the experimental group during the immediate postoperative period compared with the control group, but this difference diminished over time. No significant differences were observed in mouth opening or facial swelling between groups at any time. CONCLUSION: In site 4 °C, sterile saline solution irrigation after mandibular third molar extraction may effectively reduce early postoperative complications, particularly pain, without prolonging surgical duration.


Assuntos
Dente Serotino , Dor Pós-Operatória , Solução Salina , Irrigação Terapêutica , Extração Dentária , Dente Impactado , Humanos , Dente Serotino/cirurgia , Solução Salina/administração & dosagem , Irrigação Terapêutica/métodos , Adulto , Masculino , Dor Pós-Operatória/prevenção & controle , Feminino , Dente Impactado/cirurgia , Mandíbula/cirurgia , Complicações Pós-Operatórias/prevenção & controle , Edema/prevenção & controle , Edema/etiologia , Medição da Dor
19.
Quintessence Int ; 55(5): 380-390, 2024 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-38619256

RESUMO

OBJECTIVES: This study examined the impact of injectable platelet-rich fibrin (iPRF) and concentrated growth factor on postoperative pain, edema, trismus, and quality of life in impacted mandibular third molar surgery. The primary aim of this study was to minimize common sequelae following third molar surgery by using iPRF and concentrated growth factor. The secondary objective was to compare the postoperative effects of these products. METHOD AND MATERIALS: This study represents a single-center, randomized prospective clinical trial conducted at the Ordu University Faculty of Dentistry. It involved patients who underwent third molar surgery for various reasons between July and October 2022. The predictor variables were the use of concentrated growth factor and i-PRF. They were categorized as concentrated growth factor, i-PRF, and control groups. The outcome variables include pain levels and analgesic consumption measured on a visual analog scale, distances between predetermined anatomical points, maximum mouth opening capacity, and data from the postoperative symptom severity (PoSSe) scale. Some statistical tests were performed with a 95% confidence interval, which was considered significant. RESULTS: Total analgesic use was notably lower in the concentrated growth factor group (P = .044). Concentrated growth factor and iPRF outperformed the control group in all edema measurements by postoperative day 7 (tragus-pogonion, lateral canthus-angulus, tragus-commissura; P < .05). Concentrated growth factor significantly reduced trismus on days 2 and 7. Quality of life was notably higher in the concentrated growth factor group than in the control group (P = .026), although iPRF group differences were not significant. CONCLUSION: The results indicate that concentrated growth factor has a limited impact on postoperative pain, but significantly reduces edema, trismus, and enhances quality of life. The iPRF group experienced positive effects on pain, edema, and trismus, although the statistically significant differences observed with concentrated growth factor highlight its potential for use instead of iPRF after third molar surgery. An increased sample size is essential for more comprehensive results.


Assuntos
Edema , Dente Serotino , Dor Pós-Operatória , Fibrina Rica em Plaquetas , Qualidade de Vida , Dente Impactado , Trismo , Humanos , Dente Serotino/cirurgia , Dente Impactado/cirurgia , Feminino , Masculino , Estudos Prospectivos , Dor Pós-Operatória/prevenção & controle , Adulto , Edema/prevenção & controle , Edema/etiologia , Trismo/prevenção & controle , Trismo/etiologia , Complicações Pós-Operatórias/prevenção & controle , Extração Dentária , Medição da Dor , Peptídeos e Proteínas de Sinalização Intercelular/uso terapêutico
20.
Clin Nephrol ; 101(6): 308-316, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38577748

RESUMO

OBJECTIVE: Tolvaptan is a vasopressin V2 receptor antagonist that is commonly prescribed to alleviate edema associated with renal diseases. However, the clinical benefits of tolvaptan in chronic kidney disease (CKD) remain unclear. This study aimed to evaluate the effectiveness of tolvaptan in managing edema caused by CKD. MATERIALS AND METHODS: The efficacy and treatment regimen of tolvaptan were assessed in a cohort of 96 patients with renal edema and CKD. During the treatment, the patients' creatinine (CR), uric acid (UA), and estimated glomerular filtration rate (eGFR) were monitored as important indicators of kidney function. Coagulation-associated molecules including fibrinogen, D-dimer, and fibrin degradation products (FDPs) were measured. Electrolyte disorders and acute kidney injury were closely monitored. Tolvaptan was administered at a daily dose of 7.5 mg, and 30 mg of edoxaban was administered to manage deep vein thrombosis. RESULTS: During the course of tolvaptan therapy, the eGFR of the patients was not declined. Edema was eliminated in 82.18% of patients. Proteinuria was reduced in the patients (p < 0.05). There were no significant changes in serum sodium levels throughout treatment, and no significant difference was observed in blood volume between the end of treatment and baseline levels. Importantly, acute kidney injury did not occur, and renal edema and deep vein thrombosis were successfully treated. CONCLUSION: As long as a rational treatment regimen is followed, tolvaptan is a safe and effective diuretic for treating edema in CKD, even in the late stages of CKD without reducing residual renal function in the patients.


Assuntos
Antagonistas dos Receptores de Hormônios Antidiuréticos , Edema , Taxa de Filtração Glomerular , Insuficiência Renal Crônica , Tolvaptan , Humanos , Tolvaptan/uso terapêutico , Masculino , Feminino , Antagonistas dos Receptores de Hormônios Antidiuréticos/uso terapêutico , Pessoa de Meia-Idade , Insuficiência Renal Crônica/complicações , Insuficiência Renal Crônica/tratamento farmacológico , Idoso , Taxa de Filtração Glomerular/efeitos dos fármacos , Edema/tratamento farmacológico , Edema/etiologia , Resultado do Tratamento , Adulto , Creatinina/sangue , Benzazepinas/uso terapêutico
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