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1.
Dis Markers ; 2022: 4614099, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36061351

RESUMO

Objective: To analyze the correlation between the levels of gastrin, serum IGF-1, and GHBP and growth and development in children with short stature (SS) using the big data. Methods: By means of retrospective analysis, the clinical data of 42 children with SS admitted to our hospital from October 2020 to October 2021 were selected as the study group, while 30 children with the healthy physical examination results in the corresponding period were selected as the control group to measure the growth and development indices and the levels of gastrin, serum IGF-1, and GHBP. The Pearson correlation analysis was used for the relationship between the levels of gastrin, serum IGF-1, and GHBP and growth and development indices in children with SS, and the targeted intervention measures were formulated by the analysis of experimental data. Results: Compared with the study group, the height, weight, and bone mineral density (BMD) Z-scores of children in the control group were obviously higher (P < 0.001). The levels of gastrin, serum IGF-1, and GHBP in the study group were markedly lower than those in the control group (P < 0.05). The Pearson correlation analysis showed that the gastrin, serum IGF-1, and GHBP of children were positively correlated with growth and development indices (P < 0.001). The levels of gastrin, serum IGF-1, and GHBP in children were distinctly improved after treatment (P < 0.05). Conclusion: The gastrin, serum IGF-1, and GHBP are closely related to the SS, and the effective clinical intervention can better improve the above indicators of children to promote their growth and development.


Assuntos
Proteínas de Transporte , Análise de Dados , Gastrinas , Fator de Crescimento Insulin-Like I , Big Data , Estatura , Proteínas de Transporte/sangue , Criança , Correlação de Dados , Gastrinas/sangue , Humanos , Fator de Crescimento Insulin-Like I/metabolismo , Estudos Retrospectivos
2.
PLoS One ; 17(9): e0274274, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36067205

RESUMO

PURPOSE: Growth failure is common in radiotherapy-treated long-term survivors of pediatric brain tumors, but studies on longitudinal growth in this patient group are lacking. Here, the aim was to assess the changes in growth patterns before and after brain tumor diagnosis, the adult height, and the risk factors for compromised growth. The incidence and treatment practices of growth hormone deficiency were analyzed. METHODS: A cohort of 73 survivors of childhood brain tumor (median age 27.2 years, range 16.2 to 43.8 years) was studied after a median follow-up period of 20.4 years from diagnosis (IQR 14.9 to 22.9 years). Patients were treated in five university hospitals in Finland between 1970 and 2008. Growth curves, final height, and patient- and disease-related risk factors for compromised growth during different growth periods were analyzed. Laboratory analyses for IGF-1 and IGFBP-3 were performed at the follow-up. RESULTS: Growth failure was evident at diagnosis, with a mean height decline of -0.6 SDS (standard deviation score) from birth (95% CI -1.15 to -0.05). Mean height SDS decline after the diagnosis was -1.09 SDS (95%CI -1.51 to -0.66). At follow-up, 37% of the study subjects (27/73) had true short stature (height < -2 SDS). The mean height deficit corrected for target height was -1.9 SDS (95% CI -1.45 to -2.40). Growth failure was associated with the age at diagnosis, corticosteroid dose, radiotherapy modality and mean dose of irradiation in the thalamic area. Low IGF-1 level (below -2.0 SDS) was found in 32% (23/72), and untreated growth hormone deficiency in 40% (29/72) of the subjects. CONCLUSION: Longitudinal growth impairment was common in radiotherapy-treated survivors of childhood brain tumor, resulting in compromised adult height. Loss of growth potential was evident already at diagnosis and further accelerated by the treatments. At young adulthood, unrecognized growth hormone deficiency was common.


Assuntos
Neoplasias Encefálicas , Hormônio do Crescimento Humano , Adolescente , Adulto , Estatura , Neoplasias Encefálicas/complicações , Neoplasias Encefálicas/tratamento farmacológico , Neoplasias Encefálicas/radioterapia , Criança , Insuficiência de Crescimento/tratamento farmacológico , Hormônio do Crescimento , Humanos , Fator de Crescimento Insulin-Like I/análise , Sobreviventes , Adulto Jovem
3.
BMJ Paediatr Open ; 6(1)2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-36053660

RESUMO

OBJECTIVE: The aim of this observational study was to evaluate the UK and Dutch referral criteria for short stature to determine their sensitivity and specificity in predicting pathological short stature. Adherence to the recommended panel of investigations was also assessed. STUDY DESIGN: Retrospective review of medical records to examine the auxological parameters, investigations and diagnosis of subjects referred to two paediatric endocrine clinics at the Royal London Children's Hospital between 2016 and 2021. We analysed: height SD score (HtSDS), height SDS minus target height SDS (Ht-THSDS) and height deflection SDS (HtDefSDS). The UK referral criteria were HtSDS <-2.7, Ht-THSDS >2.0 and HtDefSDS >1.3. The Dutch referral criteria were HtSDS <-2.0, Ht-THSDS >1.6 and HtDefSDS >1.0. RESULTS: Data were available for 143 subjects (72% males) with mean (range) age 8.7 years (0.5-19.9). HtSDS and Ht-THSDS were significantly lower in the pathological stature (n=66) versus the non-pathological stature (n=77) subjects (-2.67±0.82 vs -1.97±0.70; p<0.001 and -2.07±1.02 vs -1.06±0.99; p<0.001, respectively). The sensitivity and specificity to detect pathology was 41% and 83% for the UK criteria (HtSDS <-2.7) compared with 59% and 79% for the Dutch criteria (HtSDS <-2.0), 48% and 83% for UK criteria (Ht-THSDS <-2.0) compared with 74% and 72% for Dutch criteria (Ht-THSDS <-1.6) and 33% and 68% for UK criteria (HtDefSDS >1.3) compared with 44% and 63% for the Dutch criteria (HtDefSDS >1.0). On average, each patient had 88% of the recommended investigations, and 53% had all the recommended testing. New pathology was identified in 36% of subjects. CONCLUSIONS: In isolation, the UK auxological referral thresholds have limited sensitivity and specificity for pathological short stature. The combination of HtSDS and Ht-THSDS improved the sensitivity of UK criteria to detect pathology from 41% to 68%. Attention to the child's genetic height potential prior to referral can prevent unnecessary assessments.


Assuntos
Estatura , Nanismo , Criança , Feminino , Transtornos do Crescimento/diagnóstico , Humanos , Masculino , Encaminhamento e Consulta , Reino Unido
4.
BMC Pediatr ; 22(1): 529, 2022 09 06.
Artigo em Inglês | MEDLINE | ID: mdl-36068546

RESUMO

BACKGROUND: Although associations between cumulative risk, sleep, and overweight/obesity have been demonstrated, few studies have examined relationships between these constructs longitudinally across childhood. This study investigated how cumulative risk and sleep duration are related to current and later child overweight/obesity in families across the United States sampled for high sociodemographic risk. METHODS: We conducted secondary analyses on 3690 families with recorded child height and weight within the Fragile Families and Child Well-Being Study. A cumulative risk composite (using nine variables indicating household/environmental, family, and sociodemographic risk) was calculated for each participant from ages 3-9 years. Path analyses were used to investigate associations between cumulative risk, parent-reported child sleep duration, and z-scored child body mass index (BMI) percentile at ages 3 through 9. RESULTS: Higher cumulative risk experienced at age 5 was associated with shorter sleep duration at year 9, b = - 0.35, p = .01, 95% CI [- 0.57, - 0.11]. At 5 years, longer sleep duration was associated with lower BMI, b = - 0.03, p = .03, 95% CI [- 0.06, - 0.01]. Higher cumulative risk at 9 years, b = - 0.34, p = .02, 95% CI [- 0.57, - 0.10], was concurrently associated with shorter sleep duration. Findings additionally differed by child sex, such that only male children showed an association between sleep duration and BMI. CONCLUSIONS: Results partially supported hypothesized associations between child sleep duration, cumulative risk, and BMI emerging across childhood within a large, primarily low socioeconomic status sample. Findings suggest that reducing cumulative risk for families experiencing low income may support longer child sleep duration. Additionally, child sleep duration and BMI are concurrently related in early childhood for male children.


Assuntos
Sobrepeso , Obesidade Pediátrica , Estatura , Índice de Massa Corporal , Criança , Pré-Escolar , Humanos , Masculino , Sobrepeso/epidemiologia , Sobrepeso/etiologia , Obesidade Pediátrica/epidemiologia , Obesidade Pediátrica/etiologia , Sono
5.
J Health Popul Nutr ; 41(1): 43, 2022 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-36109796

RESUMO

BACKGROUND: Adult height is a cumulative indicator of living standards with mean height increasing with a greater socio-economic level. Guatemalan adult women have the lowest mean height worldwide. The country's population is ethnically divided between indigenous and non-indigenous groups. This study aims to identify trends in the mean height for indigenous and non-indigenous adult women born between 1945 and 1995 in Guatemala and the association with individual, household and environmental factors. METHODS: We used pooled data of adult women from five Demographic and Health Surveys. Mixed-effects multilevel linear regression models estimate the mean height associated with the explanatory variables. Mean height was modelled as a function of birth year cohort, wealth, education, geo-administrative regions and elevation. RESULTS: The mean height increased 0.021 cm per year on average. The annual increase for indigenous women was 0.027 cm, while 0.017 cm for non-indigenous women. Height is associated with household wealth and women's education level. We found an interaction effect between ethnicity and household wealth, with indigenous women at the lowest quintile 0.867 cm shorter than the corresponding non-indigenous group. Height is associated with the geo-administrative region, those women in western regions being shorter than those in the metropolis. Mean height is reduced 0.980 cm for each 1000 m increase in elevation. CONCLUSIONS: Guatemalan women have grown only 1 cm over half century, a slow improvement between 1945 and 1995, a period characterised by political instability and civil war. There are persistent inequalities in women's height associated with socio-economic status, education and attributes of the geographical context. These aspects need to be considered when implementing strategies to encourage growth. Further research is required to understand the evolution of adult height and the standard of living in post-war Guatemala.


Assuntos
Estatura , Classe Social , Adulto , Escolaridade , Etnicidade , Feminino , Humanos , Fatores Socioeconômicos
6.
Eur Rev Med Pharmacol Sci ; 26(17): 6073-6083, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36111907

RESUMO

OBJECTIVE: Basketball players often display poor balance and increased injury rates when compared to other athletic categories. Therefore, the relationship between postural control and injury risks in basketball athletes requires investigation. The purpose of this study was to: (a) establish a postural profile of elite women basketball players, (b) compare postural control of the different playing positions to detect the vulnerability of postural balance, and (c) attempt to understand the reasons underlying these differences. PATIENTS AND METHODS: 30 elite female basketball players (aged 21.4±2.3 years) were assigned to three groups according to their playing positions (n=10 guards; n=10 forwards; n=10 centers). A one-way analysis of variance was performed to determine differences between balance test variables under three conditions (static, dynamic antero-posterior and medio-lateral). When a significant main effect was observed, Tukey's post-hoc multiple comparisons tests were used to determine statistical significance. Associations between balance and morphological variables, muscle strength and power were assessed using Pearson's correlation coefficient. RESULTS: Results reveal that basketball players had better postural control than previously studied handball players and non-athletes, but they are more dependent on vision than other categories. When comparing postural controls of playing position, centers show greater vulnerability [Y mean (OE)] than forwards: p<0.001; or guards: p<0.01), due to morphological factors (body mass r=-0.80, height r=-0.68, and lower limb length r=-0.63, and specific power r=-0.40). CONCLUSIONS: Therefore, coaches and strength and conditioning specialists should give specific focus to improving lower limb strength and power in centers and taller basketball players to mitigate against injury risks related to postural control.


Assuntos
Basquetebol , Atletas , Basquetebol/fisiologia , Estatura , Feminino , Humanos , Força Muscular/fisiologia , Equilíbrio Postural
7.
J Orthop Traumatol ; 23(1): 46, 2022 Sep 17.
Artigo em Inglês | MEDLINE | ID: mdl-36114882

RESUMO

BACKGROUND: In the treatment of tall stature, the reduction of excessive predicted final height can either be achieved by hormonal treatment or surgically by temporary (tED) or permanent (pED) epiphysiodesis. The present study evaluates the preliminary results of two novel devices for tED and pED around the knee to reduce the predicted final height. MATERIALS AND METHODS: A retrospective analysis was performed to evaluate the clinical and radiographic outcome after bilateral epiphysiodesis for the treatment of tall stature. A cohort of 34 patients (16 girls, 18 boys) who underwent either tED or pED between 2015 and 2020 were eligible for analysis based on the electronic patient records and picture archiving and communication system of our orthopaedic teaching hospital. tED was conducted in 11 patients (32%) through bilateral implantation of four RigidTacks™ (Merete, Berlin, Germany) around the knee. Twenty-three patients (68%) received pED, performed with an EpiStop™ trephine (Eberle, Wurmberg, Germany). The mean overall follow-up time was 2.9 years. RESULTS: The mean age at surgery was 12.3 years in girls and 13.2 years in boys. Patients had a mean body height of 175.2 cm in girls and 184.7 cm in boys at surgery. The mean predicted final height was 191.4 cm in girls and 210.4 cm in boys. At the last follow-up, 26 patients (76.5%) had achieved skeletal maturity. The mean height of skeletally mature patients was 187.2 cm in girls and 198.5 cm in boys. A mean reduction of the predicted final height of 5.9 cm in girls and 8.7 cm in boys was achieved, corresponding to a reduction in remaining growth of 46% in girls and 38% in boys. Secondary frontal plane deformities of the knee were detected in 5/11 patients (45.5%) in the tED group and 1/23 treatments (4.3%) in the pED group. CONCLUSIONS: tED and pED have both proven to be efficient at achieving growth inhibition to reduce excessive predicted height. However, tED has been associated with an increased risk of secondary angular deformities of the knee. Furthermore, the risk of implant-related complications and the necessity of a subsequent surgical intervention for implant removal have led our study group to abandon tED when treating tall stature. Long-term results of both procedures are pending.


Assuntos
Ortopedia , Procedimentos Cirúrgicos Reconstrutivos , Estatura/fisiologia , Feminino , Transtornos do Crescimento/tratamento farmacológico , Transtornos do Crescimento/cirurgia , Humanos , Masculino , Estudos Retrospectivos
8.
Front Endocrinol (Lausanne) ; 13: 951331, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36060964

RESUMO

Noonan syndrome (NS) is a disorder characterized by a typical facial gestalt, congenital heart defects, variable cognitive deficits, skeletal defects, and short stature. NS is caused by germline pathogenic variants in genes coding proteins with a role in the RAS/mitogen-activated protein kinase signaling pathway, and it is typically associated with substantial genetic and clinical complexity and variability. Short stature is a cardinal feature in NS, with evidence indicating that growth hormone (GH) deficiency, partial GH insensitivity, and altered response to insulin-like growth factor I (IGF-1) are contributing events for growth failure in these patients. Decreased IGF-I, together with low/normal responses to GH pharmacological provocation tests, indicating a variable presence of GH deficiency/resistance, in particular in subjects with pathogenic PTPN11 variants, are frequently reported. Nonetheless, short- and long-term studies have demonstrated a consistent and significant increase in height velocity (HV) in NS children and adolescents treated with recombinant human GH (rhGH). While the overall experience with rhGH treatment in NS patients with short stature is reassuring, it is difficult to systematically compare published data due to heterogeneous protocols, potential enrolment bias, the small size of cohorts in many studies, different cohort selection criteria and varying durations of therapy. Furthermore, in most studies, the genetic information is lacking. NS is associated with a higher risk of benign and malignant proliferative disorders and hypertrophic cardiomyopathy, and rhGH treatment may further increase risk in these patients, especially as dosages vary widely. Herein we provide an updated review of aspects related to growth, altered function of the GH/IGF axis and cell response to GH/IGF stimulation, rhGH treatment and its possible adverse events. Given the clinical variability and genetic heterogeneity of NS, treatment with rhGH should be personalized and a conservative approach with judicious surveillance is recommended. Depending on the genotype, an individualized follow-up and close monitoring during rhGH treatments, also focusing on screening for neoplasms, should be considered.


Assuntos
Nanismo Hipofisário , Hormônio do Crescimento Humano , Síndrome de Noonan , Adolescente , Estatura , Criança , Hormônio do Crescimento Humano/uso terapêutico , Humanos , Síndrome de Noonan/tratamento farmacológico , Síndrome de Noonan/genética , Proteínas Recombinantes/uso terapêutico
9.
Artigo em Inglês | MEDLINE | ID: mdl-36078186

RESUMO

Preliminary studies have reported that motor control is negatively impacted following an infection of COVID-19. The purpose of this study was to evaluate the effect of COVID-19 on maintaining balance in highly skilled athletes. As part of a larger investigation that was initiated in 2019, twelve professional handball players were recruited to participate in a study that was designed to measure static balance performance. Following the initial pre-test, six participants (body height 184.8 ± 4.7 cm; body weight 85.5 ± 3.3 kg; age 21.3 ± 1.2 years) were infected with COVID-19. The remaining six participants (body height 188.7 ± 2.6 cm; body weight 92.3 ± 3.7 kg; age 26.3 ± 3.3 years) never tested positive for COVID-19 and were presumably not infected with the virus. The experimental design required all the participants to complete an initial balance assessment (pre-test) and a later balance assessment (post-test). To fully analyze our data, we conducted a 2 (condition: COVID, no-COVID) X 2 (test: pre-test, post-test) ANOVA with repeated measures on the second factor. Our analysis revealed that the skilled athletes who contracted COVID-19 had a significant decrease in balance performance from the pre-test that occurred prior to being infected with COVID-19 relative to the post-test that occurred following the COVID-19 infection. Additionally, the skilled athletes who were not infected with COVID-19 did not demonstrate the same deterioration in balance performance in the same period. This study highlights the impact COVID-19 has on static balance performance in a group of highly skilled handball players. Longitudinal studies are needed to fully understand the lasting impacts COVID-19 has on motor behavior.


Assuntos
COVID-19 , Esportes , Adulto , Atletas , Estatura , Peso Corporal , COVID-19/epidemiologia , Humanos , Adulto Jovem
10.
Artigo em Inglês | MEDLINE | ID: mdl-36078844

RESUMO

AIM: to evaluate if ACL injuries are associated with recreational skiers using rented skis and whether individual factors, ski geometry parameters and standing heights differ between skiers who rented or owned skis. A retrospective questionnaire-based, case-control study of ACL-injured and uninjured recreational skiers was conducted during six winter seasons. Age, sex, body height, body weight, nationality, ownership of skis, skill level, risk-taking behavior, ski length, side-cut radius, widths of the tip, waist, and tail, and the standing heights at the front and rear components of the ski binding were assessed. Additionally, ratios between ski widths and a standing height ratio were calculated. Altogether, 1780 skiers (48.9% females) with a mean age of 39.2 ± 13.0 years participated, of whom 22.0% sustained an ACL injury and 32.3% rented skis. ACL injury risk was significantly associated with rented skis (OR 3.2, 95% CI 2.5-4.0). Compared to skiers using own skis, participants who rented skis were more likely female, smaller and lighter, tourists, less skilled and more cautious. In comparison to owned skis, rented skis showed significantly lower mean values in ski length, side-cut radius, ski widths, and for the three ski widths ratios. Additionally, standing heights were significantly lower while standing height ratio was higher for rented skis. Beside individual factors, equipment-related factors should be considered when renting skis in order to reduce ACL injury risk.


Assuntos
Lesões do Ligamento Cruzado Anterior , Traumatismos em Atletas , Esqui , Adulto , Lesões do Ligamento Cruzado Anterior/epidemiologia , Estatura , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , Esqui/lesões
11.
Annu Int Conf IEEE Eng Med Biol Soc ; 2022: 1797-1800, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-36085778

RESUMO

Forefoot pain, hallux valgus, shoe sore, flat foot, and calluses are among the common foot problems encountered by high heel wearers. This study aimed to investigate the external forces associated with shoe sore and callus while wearing formal heel shoes. The external force on the 1st, 2nd, and 5th metatarsal heads and heel center was measured using the ShokacChip. Women were asked to wear pumps with four heel heights (10, 30, 55, and 80 mm) and walk 15 m twice. Thirty-five women were included. The data of two participants were excluded due to sensor fault. With higher heels, normal stress (pressure) was significantly stronger on the inside of the forefoot and significantly weaker on the outside. Shear stress did not always increase or decrease proportionally with respect to heel height. SPR-i of the forefoot associated with callus formation was minimal in the 30-mm heel. Clinical Relevance- This study aims to provide a guide for shoe selection in order to avoid foot troubles in women.


Assuntos
, Calcanhar , Estatura , Feminino , Humanos , Extremidade Inferior , Dor , Caminhada
12.
Annu Int Conf IEEE Eng Med Biol Soc ; 2022: 4105-4108, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-36086023

RESUMO

Muscle synergy analysis has been widely adopted in the literature for the analysis of upper limb surface electromyographic signals during reaching tasks and for the prediction of movement direction for myoelectric control purposes. However, previous studies have characterized movements in constrained or semi-constrained scenarios, in which the subjects performing the movement were instructed to reach particular targets or were given some kind of feedback. In this work, the same synergy model has been applied to a completely unconstrained upper limb reaching experiment, with the aim of classifying the height of the target starting from the activity of the synergies. Results show that the synergistic model is able to extract compact features that can identify with good performance three different reaching heights. Moreover, this representation is able to isolate the signals that contain predictive information about the movement direction from the ones that are related to movement timing; this, together with the good performance of the synergy-based classifier supports the proposal of applying this model to the pre-processing of electromyographic signals when dealing with control systems that use signals from multiple muscles to predict movements.


Assuntos
Movimento , Músculo Esquelético , Estatura , Eletromiografia , Humanos , Movimento/fisiologia , Músculo Esquelético/fisiologia , Extremidade Superior/fisiologia
13.
Nutrients ; 14(16)2022 Aug 10.
Artigo em Inglês | MEDLINE | ID: mdl-36014765

RESUMO

Background: The interaction between lean body mass (LBM) and fat mass index (FMI) with grip strength (GS) has not been explored in the same analysis model in adolescents. This study thus aims to analyze the association between FMI and LBM with GS. Methods: This cross-sectional study was conducted with data from the 2016 follow-up of the 1997/98 Birth Cohort of São Luís. Grip strength was assessed by the Jamar Plus + dynamometer. The LBM and FMI indexes were assessed [ratio of the mass (lean or fat-kg) to height (m2)]. The confounding variables identified for the relationship between FMI and LBM with GS in the same analysis model, by directed acyclic graph (DAG), were sex, age, race, work, alcohol consumption, smoking, physical activity, and consumption of ultra-processed foods and culinary preparations, used in the adjusted analysis. Results: A total of 2339 adolescents (52.5% girls) were analyzed. The boys have a higher GS than the girls. In the adjusted analysis, with each increase of 1 kg/m2 in the FMI, GS was reduced by 0.72 kgf for boys and 0.35 kgf for girls. At each increase of 1 kg/m2 in the LBM, GS increased by 2.18 kgf for boys and 1.26 kgf for girls. Conclusions: FMI was associated with lower GS regardless of the LBM. LBM was associated with higher GS regardless of the FMI.


Assuntos
Composição Corporal , Estatura , Adolescente , Índice de Massa Corporal , Estudos Transversais , Exercício Físico , Feminino , Força da Mão , Humanos , Masculino
14.
Nutrients ; 14(16)2022 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-36014811

RESUMO

BACKGROUND: Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular disorder. Young people with DMD have high rates of obesity. There is emerging evidence that a higher BMI may negatively affect clinical outcomes in DMD. This study aimed to explore the relationship between obesity and clinical outcomes in DMD. METHODS: This was a retrospective clinical audit of young people (two-21 years) with DMD. Height and weight were collected to calculate BMI z-scores to classify obesity, overweight and no overweight or obesity (reference category). Cox proportional hazards models determined the impact of obesity at five to nine years on clinical milestones including time to: loss of ambulation, timed function test cut-offs, obstructive sleep apnoea (OSA) diagnosis and first fracture. RESULTS: 158 young people with DMD were included; most (89.9%) were steroid-treated. Mean follow-up was 8.7 ± 4.7 years. Obesity prevalence increased from age five (16.7%) to 11 years (50.6%). Boys with obesity at nine years sustained a fracture earlier (hazard ratio, HR: 2.050; 95% CI: 1.038-4.046). Boys with obesity at six to nine years were diagnosed with OSA earlier (e.g., obesity nine years HR: 2.883; 95% CI: 1.481-5.612). Obesity at eight years was associated with a 10 m walk/run in 7-10 s occurring at an older age (HR: 0.428; 95% CI: 0.207-0.887), but did not impact other physical function milestones. CONCLUSIONS: Although 50% of boys with DMD developed early obesity, the impact of obesity on physical function remains unclear. Obesity puts boys with DMD at risk of OSA and fractures at a younger age. Early weight management interventions are therefore important.


Assuntos
Fraturas Ósseas , Distrofia Muscular de Duchenne , Apneia Obstrutiva do Sono , Adolescente , Estatura , Fraturas Ósseas/complicações , Humanos , Masculino , Distrofia Muscular de Duchenne/complicações , Distrofia Muscular de Duchenne/epidemiologia , Obesidade/complicações , Obesidade/epidemiologia , Estudos Retrospectivos , Apneia Obstrutiva do Sono/complicações
15.
Nutrients ; 14(16)2022 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-36014831

RESUMO

Vitamin D is essential for calcium absorption and bone homeostasis. Although short-stature children were reported to have low vitamin D concentrations, there is no clear evidence of a link between vitamin D and height growth in young children not limited to those with short stature. We collected height and weight data at 2 and 4 years of age, serum vitamin D concentrations at 4 years, and questionnaire results on sun exposure from the Japan Environment and Children's Study (JECS). We then analyzed the relationship between vitamin D deficiency and height growth. We also analyzed the correlation between serum vitamin D concentration and sun exposure. Overall, 3624 participants from JECS were analyzed. We identified cases of subclinical vitamin D deficiency and insufficiency. We further found that definitive vitamin D deficiency (<10 ng/mL) impaired height growth by 0.6 cm per year even in young children not limited to those with short stature. Furthermore, we clarified that children with vitamin D deficiency had reduced outdoor activity, especially during winter. In children with either short or normal stature, definitive vitamin D deficiency was associated with height growth decline, and reduction in outdoor activity, especially during winter, was a risk factor for vitamin D deficiency.


Assuntos
Deficiência de Vitamina D , Estatura , Criança , Pré-Escolar , Humanos , Japão/epidemiologia , Vitamina D , Deficiência de Vitamina D/complicações , Deficiência de Vitamina D/epidemiologia , Vitaminas
16.
Nutrients ; 14(16)2022 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-36014954

RESUMO

Background: Stunting has been a public health problem in several developing countries including Indonesia. One of the strategies to reduce stunting was family assistance. This study was aimed to estimate the effect of family assistance by using an integrative nutrition package through home visits on the growth and development of stunted children. Method: This was an experimental study using pre-test post-test with control group design, conducted in Yogyakarta, Indonesia, on March to May 2022. The intervention group was provided an integrative nutrition package (INP) including maternal education, behavioral change through home visit, as well as monitoring children's outcome, while the control group was asked to read and follow child care procedure in the maternal and child health (MCH) book as a standard procedure. Both groups were visited by trained health volunteers and had a complementary feeding (CF) package weekly for four weeks. The outcomes of this study were the maternal outcome (knowledge and behavior on children's growth monitoring (CGM), children's development monitoring (CDM), and infant/young children feeding (IYCF) as well as children's outcomes, including body weight (BW), body height (BH), and child score development (CSD). This study used generalized estimating equation (GEE) to estimate the differences in differences (DID) of the impact of intervention compared with control group and compared among three different times (baseline, fourth, and eighth week). Results: There were 60 stunted children under five years in this study, i.e., 30 in intervention group and 30 in control group. From the GEE analysis, it was found that the regression adjusted DID showed statistically significant increase of all outcomes including children's development score (CDS). The adjusted DID effect (95% CI) on 8th week for children's weight, height, and development score were 0.31 (0.25-0.37), 0.41 (0.13-0.68), and -0.40 (-0.59-(-0.21)), respectively, among the intervention group. Conclusions: INP through home visit successfully increased maternal and children's outcomes compared witsh standard procedure. The effect of intervention was found to be consistently significant in the fourth and eighth weeks after intervention. We recommend the local government to apply INP through home visit especially in high-prevalence stunting areas.


Assuntos
Transtornos do Crescimento , Visita Domiciliar , Estatura , Pré-Escolar , Feminino , Transtornos do Crescimento/epidemiologia , Transtornos do Crescimento/prevenção & controle , Humanos , Indonésia/epidemiologia , Lactente , Estado Nutricional
17.
Front Endocrinol (Lausanne) ; 13: 936005, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35992102

RESUMO

Objective: To determine whether the timing of puberty associates with school performance. Methods: Growth data on 13,183 children born between 1997 and 2002, were collected from child health clinics and school healthcare and school performance data from school records. Age at peak height velocity (PHV) marked pubertal timing. The relationships between age at PHV and average grades in mathematics, native language, English, and physical education from school years 6 (end of elementary school; age 11-12 years), 7 (start of middle school; 12-13 years), and 9 (end of middle school; 14-15 years) were modeled using generalized estimating equations and linear mixed models, adjusted for the month of birth and annual income and education levels in school catchment areas. Results: The mean (SD) age at PHV was 13.54 (1.17) years in boys and 11.43 (1.18) years in girls. In girls, age at PHV was associated with grades in mathematics (ß=0.041-0.062, p<0.005) and physical education (ß=0.077-0.107, p<0.001) across the study years, and in school year 9, also with grades in English (ß=-0.047, 95%CI -0.072 to -0.021, p<0.001). Among boys, only the grades in physical education were related to age at PHV across the study years (ß=0.026-0.073, p<0.01) and in middle school the grades in mathematics decreased dramatically. Conclusions: In both sexes, the timing of puberty was associated with the grades in physical education, and in girls, with academic achievement. The decrease in boys' mathematics grades and sex difference in academic achievement were unexplained by the timing of puberty.


Assuntos
Estatura , Puberdade , Criança , Feminino , Humanos , Masculino
18.
Sci Rep ; 12(1): 13835, 2022 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-35974069

RESUMO

Neuromuscular fatigue tests have been used in previous studies to organize post-match training programs and to minimize injuries. The aim of this study is to describe the neuromuscular fatigue that occurs after a football match and to examine the relationship between internal and external load values in the match and fatigue parameters obtained at different time intervals. Twenty male U19 academy league soccer players (age: 19; height: 181.3 ± 4.3; weight: 73.4 ± 6.7) participated in the study. The countermovement jump (CMJ) test was applied to the players 24 h before, as well as 24, 48, 72, 96, and 120 h after a football match. During the CMJ tests, the maximum velocity of each player during the jump was recorded by using the GymAware linear position transducer. The CMJ maximum velocity values 24 h before and 24 h after the match, as well as the CMJ height values (Cohen's d: 1.210; p < 0.001), were statistically different from the values recorded 24 h before and 24 and 48 h after the match (Cohen's d: 1.578; p < 0.001; Cohen's d: 0,922; p < 0.009). The correlation values were not statistically significant. The results suggest, CMJ height and CMJ maximum velocity values, which determine neuromuscular fatigue after a football match, can be used by practitioners to display post-match neuromuscular fatigue measurements.


Assuntos
Desempenho Atlético , Futebol Americano , Fenômenos Fisiológicos do Sistema Nervoso , Futebol , Adulto , Estatura , Humanos , Masculino , Fadiga Muscular , Adulto Jovem
19.
Comput Math Methods Med ; 2022: 8586355, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35979052

RESUMO

Objective: To explore the effect of continuous nutrition management intervention based on mobile medical APP on the nutritional status and development of premature infants. Methods: Eighty premature infants treated in our hospital from May 2019 to April 2021 were enrolled. The patients were randomly divided into the control group and research group. The control group received routine nursing, and the research group received continuous nutrition management intervention based on mobile medical APP. The Neonatal Behavioral Neurological Assessment (NBNA) score, pain score, height, weight, head circumference, intellectual development score, serum Prealbumin (PA), retinol-binding protein (RBP), and disease occurrence were elucidated. Results: First of all, the NBNA scores of the two groups were compared. The behavioral ability, passive muscle tension, active muscle tension, original reflex, and general evaluation scores of the research group were significantly higher when compared to the control. Secondly, we compared the pain scores of the two groups, there was no significant difference between the two groups before nursing (P > 0.05), but the pain scores of the research group were lower compared to the control group during the period of blood collection, recovery, discharge, and 6 months after discharge (P < 0.05). Compared with the growth and development indexes of the two groups, there was no significant difference between the two groups before nursing (P > 0.05). After nursing, the GDS score of the two groups increased, and the GDS score of the research group was higher than that of the control group. The difference of data was statistically significant (P < 0.05). Compared with the motor scores of the two groups, there was no significant difference between the two groups before nursing (P > 0.05). After nursing, the motor scores of the two groups increased, and the scores of PDMS-2 and TIMP in the research group were higher than those in the control group, and the difference was statistically significant (P < 0.05). There was no significant difference in serum PA and RBP before nursing, but the serum PA and RBP in the two groups increased after nursing, and the PA and RBP in the research group were higher than those in the control group, and the difference was statistically significant (P < 0.05). Finally, we compared the incidence of diseases between the two groups. Before nursing, the incidence of infection, retinopathy, chronic lung injury and anemia in the research group was lower, when compared to the control, and the difference was statistically significant (P < 0.05). Conclusion: The intervention strategy of continuous nutrition management based on mobile medical APP for premature infants can significantly strengthen their nutritional status after discharge, promote their growth and development, improve their nutritional status, reduce the incidence of diseases in premature infants, and then enhance their quality of life.


Assuntos
Estado Nutricional , Qualidade de Vida , Estatura , Humanos , Lactente , Recém-Nascido , Recém-Nascido Prematuro , Dor
20.
Front Endocrinol (Lausanne) ; 13: 882840, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35937794

RESUMO

Introduction: The relationship between the characteristics of puberty growth and the stature (height and overweight and obesity) in late adolescence was not clear. We aimed to explore the effects of puberty growth patterns on the stature in late adolescence. Methods: A total of 13,143 children from a longitudinal cohort from 2006 to 2016 in Zhongshan city of China were included. The Preece-Baines growth curve was fitted for each individual child, and the age at peak height velocity (APHV), peak height velocity (PHV), and age at take-off (TOA) were obtained from the Preece-Baines model. To compare the difference in height in late adolescence (at 18 years old) at different pubertal height growth patterns (height spurt timing, intensity, and duration), the height at baseline was matched by using the propensity score matching. The log-binomial model was applied to assess the association between the three pubertal height growth patterns (timing, intensity, and duration) and overweight and obesity status in late adolescence, controlling the urbanity and body mass index (BMI) at baseline. Results: After matching the baseline height, boys and girls in three pubertal patterns with early timing (P < 0.01), small intensity (P < 0.01), and short duration (P < 0.01) of height spurt had the lowest final height in the late adolescence. A 16% increase and 45% increase of risk for overweight and obesity were significantly associated with the early APHV in boys and girls, respectively, relative risk (RR) in boys, 1.16(95% confidence interval, CI: 1.03-1.30), P = 0.011; RR in girls, 1.45(1.21-1.75), P < 0.001. A 21% increase and 59% increase of risk for overweight and obesity were significantly associated with small PHV in boys and girls, respectively, RR in boys, 1.21(1.07-1.36), P < 0.001; RR in girls, 1.59(1.30-1.95), P < 0.001; and an 80% increase of risk for overweight and obesity with small spurt duration in girls (RR = 1.80; 95% CI: 1.49, 2.18; P < 0.001). Conclusion: Pubertal growth patterns, including earlier puberty onset timing, smaller puberty intensity, and shorter puberty spurt duration, had a positive association with lower height risks and higher overweight and obesity risks in late adolescence.


Assuntos
Sobrepeso , Puberdade , Adolescente , Estatura , Criança , Feminino , Humanos , Estudos Longitudinais , Masculino , Obesidade , Sobrepeso/epidemiologia
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