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1.
Artigo em Inglês | MEDLINE | ID: mdl-36209958

RESUMO

Aquaculture has greater potential for seafood production than wild capture fisheries. To meet the growing demand for seafood, China's marine aquaculture industry has begun building deep-water cages in the open sea. However, under these conditions, fish encounter strong currents and waves, and ensuring their healthy growth is key to the farming process. To address these issues, it is necessary to study the sustained swimming abilities of cultured fish species. Blackhead seabream (Acanthopagrus schlegelii) and red drum (Sciaenops ocellatus) are traditional economic fish species in China; however, their sustained swimming ability under a constant current has been underexplored. Therefore, we examined the endurance swimming ability of three size classes of blackhead seabream and red drum at 20 °C. The fish were then subjected to swimming tests of 0, 30, 60, 90, 120, and 150 min at a constant swimming speed of 0.55 m/s (0.80 m/s), 0.65 m/s (0.90 m/s), and 0.70 m/s (0.98 m/s). The fish were then dissected to obtain muscle, blood, and liver samples; sample metabolite concentrations were measured at six time points, each of which guaranteed five sets of valid data. The results indicated that red drum has a significantly stronger swimming ability, and can be cultured in waters with a short-term flow rate not exceeding 0.75 m/s or 3.5 BL/s. Further, blackhead seabream can be cultured in waters with a flow velocity lower than 0.55 m/s or 2.5 BL/s. The species-related metabolic differences were mainly reflected in the hepatic glycogen and blood glucose concentrations, and those in swimming ability caused by body length were mainly reflected by the hepatic glycogen concentration. The hepatic glycogen concentration had the most significant effect on fish with body lengths >28 cm (P < 0.05). Overall, the experimental results indicated that the liver plays a major role in the physiological level of fish swimming fatigue, providing a direction for further research.


Assuntos
Perciformes , Dourada , Animais , Natação/fisiologia , Glicogênio Hepático , Fadiga
2.
Physiol Behav ; 258: 114010, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36349660

RESUMO

Sustained operations (SUSOPS) require military personnel to conduct combat and training operations while experiencing physical and cognitive stress and limited sleep. These operations are often conducted in a state of negative energy balance and are associated with degraded cognitive performance and mood. Whether maintaining energy balance can mitigate these declines is unclear. This randomized crossover study assessed the effects of energy balance on cognitive performance, risk-taking propensity, ambulatory vigilance, and mood during a simulated 72-h SUSOPS. METHODS: Ten male Soldiers (mean ± SE; 22.4 ± 1.7 y; body weight 87.3 ± 1.1 kg) completed two, 72-h simulated SUSOPS in random order, separated by 7 days of recovery. Each SUSOPS elicited ∼4500 kcal/d total energy expenditure and restricted sleep to 4 h/night. During SUSOPS, participants consumed either an energy-balanced or restricted diet that induced a 43 ± 3% energy deficit. A cognitive test battery was administered each morning and evening to assess: vigilance, working memory, grammatical reasoning, risk-taking propensity, and mood. Real-time ambulatory vigilance was assessed each morning, evening, and night via a wrist-worn monitoring device. RESULTS: Participants exhibited heightened risk-taking propensity (p = 0.047) with lower self-reported self-control (p = 0.021) and fatigue (p = 0.013) during energy deficit compared to during energy balance. Vigilance accuracy (p < 0.001) and working memory (p = 0.040) performance decreased, and vigilance lapses increased (p < 0.001) during SUSOPS, but did not differ by diet. Percentage of correct responses to ambulatory vigilance stimuli varied during SUSOPS (p = 0.019) independent of diet, with generally poorer performance during the morning and night. Total mood disturbance (p = 0.001), fatigue (p < 0.001), tension (p = 0.003), and confusion (p = 0.036) increased whereas vigor decreased (p < 0.001) during SUSOPS, independent of diet. CONCLUSION: Prolonged physical activity combined with sleep restriction is associated with impaired vigilance, memory, and mood state. Under such conditions, maintaining energy balance prevents increased risk-taking and improves self-control, but does not improve other aspects of cognitive function or mood. Given the small sample in the present study, replication in a larger cohort is warranted.


Assuntos
Militares , Humanos , Masculino , Militares/psicologia , Estudos Cross-Over , Afeto/fisiologia , Cognição/fisiologia , Fadiga/psicologia , Metabolismo Energético , Assunção de Riscos , Privação do Sono
3.
Int J Cancer ; 152(2): 214-226, 2023 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-36054767

RESUMO

The underlying biological mechanisms causing persistent fatigue complaints after colorectal cancer treatment need further investigation. We investigated longitudinal associations of circulating concentrations of 138 metabolites with total fatigue and subdomains of fatigue between 6 weeks and 2 years after colorectal cancer treatment. Among stage I-III colorectal cancer survivors (n = 252), blood samples were obtained at 6 weeks, and 6, 12 and 24 months posttreatment. Total fatigue and fatigue subdomains were measured using a validated questionnaire. Tandem mass spectrometry was applied to measure metabolite concentrations (BIOCRATES AbsoluteIDQp180 kit). Confounder-adjusted longitudinal associations were analyzed using linear mixed models, with false discovery rate (FDR) correction. We assessed interindividual (between-participant differences) and intraindividual longitudinal associations (within-participant changes over time). In the overall longitudinal analysis, statistically significant associations were observed for 12, 32, 17 and three metabolites with total fatigue and the subscales "fatigue severity," "reduced motivation" and "reduced activity," respectively. Specifically, higher concentrations of several amino acids, lysophosphatidylcholines, diacylphosphatidylcholines, acyl-alkylphosphatidylcholines and sphingomyelins were associated with less fatigue, while higher concentrations of acylcarnitines were associated with more fatigue. For "fatigue severity," associations appeared mainly driven by intraindividual associations, while for "reduced motivation" stronger interindividual associations were found. We observed longitudinal associations of several metabolites with total fatigue and fatigue subscales, and that intraindividual changes in metabolites over time were associated with fatigue severity. These findings point toward inflammation and an impaired energy metabolism due to mitochondrial dysfunction as underlying mechanisms. Mechanistic studies are necessary to determine whether these metabolites could be targets for intervention.


Assuntos
Sobreviventes de Câncer , Neoplasias Colorretais , Humanos , Sobreviventes , Fadiga/etiologia , Plasma , Neoplasias Colorretais/complicações
4.
J Surg Res ; 281: 185-191, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36179596

RESUMO

INTRODUCTION: Total thyroidectomy (TT) has been shown to be a safe and effective treatment for Graves' disease. However, the time course for improvement of symptoms has not been defined. METHODS: With an institutional review board approval, we prospectively gathered survey data of all patients (n = 79) undergoing TT for Graves' disease at a single institution from 2019 to 2021. After informed consent was obtained, patients completed surveys preoperatively and at 2 wk followed by monthly postoperative visits/phone calls. Patient demographics and survey results were collected and analyzed. Symptom recovery time was evaluated using Kaplan-Meier analysis. RESULTS: A total of 50 patients completed the survey on postoperative follow-up (response rate 63%). Average age was 38 y (range 12-80 y) and 88% of patients were female. The most common preoperative symptoms were fatigue (90%) and heat/cold intolerance (88%). Tremor (median time to resolution: 1 wk; interquartile range [IQR] 1-3), diarrhea (median 1 wk [IQR 1-3]), and palpitations (median 1 wk [IQR 1-3]) resolved the most rapidly followed by eye symptoms (median 3 wk [IQR 1-6]), heat/cold intolerance (median 3 wk [IQR 3-30]), memory deficits (median 3 wk [IQR 1-undefined]), and fatigue (median: 3 wk [IQR 1-14]). There were no significant differences in time to resolution of symptoms by gender or age (less than versus 40 y and older). Those with uncontrolled Graves' had more severe symptoms but no difference in time to resolution from the euthyroid Graves' patients. CONCLUSIONS: Many Graves' disease symptoms improve rapidly following TT, with a median time to improvement of less than 1 mo.


Assuntos
Doença de Graves , Tireoidectomia , Humanos , Feminino , Adulto , Masculino , Tireoidectomia/efeitos adversos , Tireoidectomia/métodos , Doença de Graves/cirurgia , Resultado do Tratamento , Fadiga
5.
Brain Res ; 1798: 148156, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36343724

RESUMO

This study evaluated the impact of rapid heat stress on prefrontal cortex (PFC) oxygenation and hemodynamics. Previous work has demonstrated that heat stress affects cerebral oxygenation and hemodynamics. Fourteen male subjects performed a graded exercise test to a termination criterion (volitional maximum, core temperature = 39.5 °C, or a 2-hour time cap) with (GEAR) and without (NOGEAR) firefighting gear in a laboratory with an ambient temperature of 25-26 °C. Changes in oxyhemoglobin (O2Hb), total hemoglobin (tHb), and tissue oxygen saturation index (TSI %) were monitored in the left and right PFC using near-infrared spectroscopy (NIRS). Significant NIRS results were a plateau in the left-side O2Hb and tHb at 80 % of the time to termination (TTT) in NOGEAR, and 60 % of TTT in GEAR. These TTT points were when the subject's core temperature (Tc) was equal to 38 °C. Additionally, there was higher left-side PFC activation during GEAR, as indicated by a significant decrease in TSI % from start to end of exercise and double the reduction in TSI % per minute in PPE compared to NOGEAR. There were no significant differences during the NOGEAR session. These data suggest that a rapid heat stress scenario (GEAR) causes altered cerebral oxygenation and hemodynamic response in the left-side PFC. The left PFC could be working harder to prevent fatigue in GEAR. This could affect cognitive processes during or following exercise in the heat while wearing personal protective equipment. Our results also support previous research demonstrating that NIRS is a sensitive metric of fatigue.


Assuntos
Bombeiros , Humanos , Masculino , Oxigênio , Oxiemoglobinas/metabolismo , Hemodinâmica/fisiologia , Córtex Pré-Frontal/metabolismo , Resposta ao Choque Térmico , Fadiga , Consumo de Oxigênio , Hemoglobinas/metabolismo
6.
Appl Ergon ; 107: 103922, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36335654

RESUMO

To investigate the variability-fatigue and repeaters-replacers hypotheses, motor variability (MV) and indicators of fatigue were assessed during repetitive lifting. Eighteen participants performed sequential repetitive bouts of lifting divided into a short bout, and three phases of a prolonged bout until volitional fatigue (or until a 1-h time limit). Whole-body kinematics were collected to calculate variability in three-dimensional joint angles and in continuous relative phase (CRP) of sagittal joint angle couplings, which were summed for the upper and lower body, and whole-body. Excellent individual consistency (ICC = 0.95-0.97) was demonstrated across lifting bouts as fatigue developed. Therefore, strong evidence was obtained for MV as an individual trait in support of the repeaters-replacers hypothesis. Associations were found for endurance and baseline effort with lower body variability, while no associations were found for rate of fatigue. Thus, some support was found for the variability-fatigue hypothesis which suggests that repeaters are less fatigue-resistant than replacers.


Assuntos
Remoção , Fadiga Muscular , Humanos , Fenômenos Biomecânicos , Fadiga/etiologia
8.
Proc Natl Acad Sci U S A ; 119(49): e2210819119, 2022 Dec 06.
Artigo em Inglês | MEDLINE | ID: mdl-36454755

RESUMO

Hemolysis usually happens instantly when red blood cells (RBCs) rupture under a high shear stress. However, it is also found to happen gradually in the extracorporeal membrane oxygenation (ECMO) under low but periodic squeezes. In particular, the gradual hemolysis is accompanied by a progressive change in morphology of RBCs. In this work, the gradual hemolysis is studied in a microfluidic device with arrays of narrow gaps the same as the constructions in ECMO. RBCs are seen to deform periodically when they flow through the narrow gaps, which causes the release of adenosine-triphosphate (ATP) from RBCs. The reduced ATP level in the cells leads to the fatigue of RBCs with the progressive changes in morphology and the gradual loss of deformability. An empirical model for the fatigue of RBCs is established under the periodic squeezes with controlled deformation, and it reveals a different way of the hemolysis that is dominated by the squeeze frequency. This finding brings a new insight into the mechanism of hemolysis, and it helps to improve the design of circulatory support devices.


Assuntos
Oxigenação por Membrana Extracorpórea , Hemólise , Humanos , Eritrócitos , Fadiga , Trifosfato de Adenosina
9.
Med Probl Perform Art ; 37(4): 249-258, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36455109

RESUMO

OBJECTIVE: The circus professionalization process entails extensive training to mitigate the high-risk demands which increase stress in artists. In high-risk professions, everyday hassles (challenges) contribute greatly to overall stress. To capture the impact of daily challenges on student-artists, the aim of the current study was to describe the magnitude and pattern of daily challenges as well as their relationships with perceived coping, anxiety, fatigue, and psychological distress. METHODS: Ninety-two students at École Nationale de Cirque (ENC), in Montreal, Canada, completed the Circus Daily Challenges Questionnaire (CDCQ) and scales assessing perceived coping, state anxiety, and fatigue at four time points over 1 school year. The Kessler 6 Non-Specific Psychological Distress Scale (K6) was implemented at one time point. RESULTS: Findings revealed significant fluctuations in challenge level and management of challenges throughout the school year, with schedule, technical development, artistic expression, physical preparation, and sleep reported as high during the two examination periods. The lowest challenge-level scores were achieved following the extended breaks in the annual calendar. Daily challenge positively correlated to state anxiety and fatigue, and negatively correlated with perceived coping. The student-artists reported higher prevalence of moderate psychological distress to general populations. CONCLUSION: Befitting the Stress Process Model, a strong interplay between variables was observed, and the life challenges assessment provides a basis for interventions based upon commonalities across the group, as well as individually tailored.


Assuntos
Instituições Acadêmicas , Estudantes , Humanos , Estudos Longitudinais , Ansiedade/epidemiologia , Fadiga
10.
J Musculoskelet Neuronal Interact ; 22(4): 455-464, 2022 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-36458383

RESUMO

OBJECTIVE: This study examined the time course of changes in torque and electromyographic (EMG) and mechanomyographic (MMG) responses during a sustained isometric task anchored to a constant perception of exertion (RPE). METHODS: Twelve college-aged men performed an isometric forearm flexion task to failure anchored to RPE=7 (OMNI-RES scale). The amplitude (AMP) and frequency (MPF) of the EMG and MMG signals from the biceps brachii were recorded. Repeated measures ANOVAs were used to examine differences for the normalized (%MVIC) torque and neuromuscular parameters. RESULTS: The time to task failure (TTF) was 678.0±468.1s. Torque decreased significantly (p<0.001, ηp2=0.774) across time and all subjects reduced torque to zero. Post-hoc comparisons indicated that the torque values from 20-100% TTF were less than the value at 10% TTF. There were no significant (p>0.05) changes from 10-100% TTF for the EMG and MMG parameters. CONCLUSION: We hypothesize that RPE was maintained by various mechanisms throughout the task: group III/IV afferent neurons, adequate blood flow, and a combination of reduced contractile efficiency, collective afferent feedback (group III/IV afferents) from muscles involved with forearm flexion, and motivation that resulted in an initial decrease, plateau, and final decline in torque to zero, respectively.


Assuntos
Antebraço , Esforço Físico , Masculino , Humanos , Adulto Jovem , Torque , Extremidade Superior , Fadiga
11.
Hu Li Za Zhi ; 69(6): 101-107, 2022 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-36455919

RESUMO

Cancer-related fatigue is the most common and longest-lasting symptom of discomfort experienced by cancer patients. Its effects on patients include physical, psychological, emotional, and cognitive stress, which greatly reduce quality of life. The field of mind-body integrated medicine has improved gradually in recent years, with many evidence-based studies supporting the efficacy of mindfulness as a symptom management strategy for cancer-related fatigue. Based on a review of the literature, this paper introduces the definition of cancer-related fatigue and related assessments and treatments, describes the origin of mindfulness and related concepts, and introduces mindfulness-based empirical treatment strategies for cancer-related fatigue, including mindfulness-based stress reduction and mindfulness-based cognitive therapy, and their effects. The findings are intended to provide clinicians with a reference for the future care of patients with cancer-related fatigue.


Assuntos
Atenção Plena , Neoplasias , Humanos , Qualidade de Vida , Fadiga/etiologia , Fadiga/terapia , Neoplasias/complicações , Cuidados Paliativos
12.
BMC Health Serv Res ; 22(1): 1469, 2022 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-36461045

RESUMO

BACKGROUND: Paramedics' fatigue is rising. Stress factors show increased risk for burnout, fatigue, leaving the profession, decreased performance and risk for patient safety. Meanwhile, paramedics' strong community of practice, autonomy and a sense of professional respect are important factors in forming psychological resilience. We aimed to explore Finnish paramedics' perceptions of job demands and resources. METHODS: Our study design was descriptive, inductive with a constructivist approach. Using reflexive thematic analysis, we analyse open-ended questions, from a web-based survey and essays written by Finnish paramedic masters-degree students. The study followed the SRQR checklist. RESULTS: We identified paramedics' job demands as stress from a high workload, environmental factors and emotional burden. Performance expectations and a sense of inadequacy were further noted, as well as an organizational culture of hardiness, presenting lack of support and sense of inequality. Paramedics' job resources were pressure management strategies, which were expressed as positive coping mechanisms, agency to affect workload and professional self-actualization, expressed as psychologically safe work community, professional pride and internal drive to professional development. CONCLUSIONS: Finnish paramedics exhibit resources and demands related to uncertainty and emotional burden as well as cultural hardiness and psychological safety in communities. PATIENT OR PUBLIC CONTRIBUTION: This study was done based on survey data collected and analysed by the authors. No patient or public contribution was utilized for this study.


Assuntos
Pessoal Técnico de Saúde , Serviços Médicos de Emergência , Humanos , Finlândia , Pesquisa Qualitativa , Fadiga
13.
Physiol Rep ; 10(23): e15529, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36461650

RESUMO

Neuromuscular efficiency is defined as the ratio of work output to stimulation rate. The purpose of these experiments was to test the hypothesis that neuromuscular efficiency would be increased in proportion to posttetanic potentiation, that is, the stimulation-induced increase in work output displayed by rodent fast-twitch muscle. To this end, extensor digitorum longus muscles from wild-type and skeletal myosin light chain kinase knockout (skMLCK-/- ) mice were surgically isolated and suspended in vitro (25°C). Concentric force development during shortening at 70% of maximal unloaded shortening velocity was tested at stimulus frequencies between 10 and 80 Hz both before and after a potentiating tetanus. A strong genotype-dependent difference in the potentiation of concentric work output was observed; concentric work output of wild-type muscles was increased by 51%-88% while that of skMLCK-/- muscles was increased by only 20%-34% across the frequencies tested. As a result, comparison of work - frequency plots revealed that the frequency required for peak and 50% peak unpotentiated work of wild-type muscles was decreased from ~80 to 52 Hz and from ~48 to 21 Hz, respectively. By contrast, the frequency required for peak and 50% peak unpotentiated work of skMLCK-/- muscles was decreased from ~80 to 68 Hz and from ~51 to 41 Hz, respectively. Thus, wild-type muscles with the ability to phosphorylate myosin displayed larger increases in neuromuscular efficiency than skMLCK-/- muscles (25-30 vs 10-15 Hz, respectively). This suggests that the presence of myosin phosphorylation may ameliorate or mitigate fatigue mechanisms associated with high-frequency stimulation rates.


Assuntos
Fadiga , Músculos , Animais , Camundongos , Genótipo , Fosforilação , Processamento de Proteína Pós-Traducional
14.
BMC Anesthesiol ; 22(1): 375, 2022 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-36463138

RESUMO

BACKGROUND: Anesthetic gases have been known to cause damage when inhaled over long periods of time. Modern safety measures have been put in place to reduce the risk to anesthesia providers, however there is continued lack of information on providers experiencing short term effects (lethargy, fatigue, headache, slowed cognitive ability, nausea, and mucosal irritation) thereby leading to long-term sequalae (sister chromatid exchanges, micronuclei, chromosomal aberrations, and comet assays). METHOD: A thirteen item, multiple choice survey was sent to 3,000 anesthesia providers, of which 463 completed the survey. A Chi-square test of independence was used to determine the association between gas exposure and participant self-reported symptoms. A Spearman's Correlation test was also utilized to interpret this data since both frequency of smelling gas and frequency of symptoms were ordinal variables for which Spearman's rho correlation was the appropriate measure of association. RESULTS: The major findings were that as the frequency of smelling anesthetic gas increased, so too did the frequency of self-reported headaches and fatigue. Spearman's rho = .148 and .092. P value = .002 and .049, respectively. CONCLUSION: There have been many efforts to decrease the risk of exposure of anesthesia providers to anesthetic gases. While there is a decrease in reported exposures, indications of possible long-term effects remain a concern in anesthesia providers. Potential implications of exposure could lead to chromosomal aberrations, sister chromatid exchanges, comet assays, spontaneous abortions, and genotoxic effects.


Assuntos
Anestésicos Inalatórios , Exposição Ocupacional , Feminino , Gravidez , Humanos , Anestésicos Inalatórios/efeitos adversos , Enfermeiras Anestesistas , Exposição Ocupacional/efeitos adversos , Aberrações Cromossômicas , Fadiga
15.
J UOEH ; 44(4): 385-388, 2022.
Artigo em Japonês | MEDLINE | ID: mdl-36464313

RESUMO

A 30-year-old woman had recognized general fatigue and joint pain 5 years before her first visit to our hospital. Keratinized skin lesions were also observed on her hand, elbows, and other interstitial sites at the same time. She was referred to our department for evaluation of her skin eruption because psoriatic arthritis was suspected. A physical examination revealed hyperkeratotic, brownish plaques on her hand, elbows, and knees. Although a skin biopsy taken from her right hand could not confirm a diagnosis, another biopsy taken from her right elbow revealed hyperkeratosis and parakeratosis with agranulosis epithelial hyperplasia, indicating a diagnosis of psoriasis. Taking an additional skin biopsy from a site other than the main one can be helpful for a diagnosis of psoriatic arthritis.


Assuntos
Artrite Psoriásica , Psoríase , Humanos , Feminino , Adulto , Artrite Psoriásica/diagnóstico , Biópsia , Exame Físico , Fadiga
16.
Front Public Health ; 10: 991350, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36339171

RESUMO

It is of great practical and theoretical significance to identify driver fatigue state in real time and accurately and provide active safety warning in time. In this paper, a non-invasive and low-cost method of fatigue driving state identification based on genetic algorithm optimization of generalized regression neural network model is proposed. The specific work is as follows: (1) design simulated driving experiment and real driving experiment, determine the fatigue state of drivers according to the binary Karolinska Sleepiness Scale (KSS), and establish the fatigue driving sample database. (2) Improved Multi-Task Cascaded Convolutional Networks (MTCNN) and applied to face detection. Dlib library was used to extract the coordinate values of face feature points, collect the characteristic parameters of driver's eyes and mouth, and calculate the Euler Angle parameters of head posture. A fatigue identification model was constructed by using multiple characteristic parameters. (3) Genetic Algorithm (GA) was used to find the optimal smooth factor of Generalized Regression Neural Network (GRNN) and construct GA-GRNN fatigue driving identification model. Compared with K-Nearest Neighbor (KNN), Random Forest (RF), and GRNN fatigue driving identification algorithms. GA-GRNN has the best generalization ability and high stability, with an accuracy of 93.3%. This study provides theoretical and technical support for the application of driver fatigue identification.


Assuntos
Condução de Veículo , Redes Neurais de Computação , Humanos , Fadiga/diagnóstico , Algoritmos , Análise por Conglomerados
17.
Front Public Health ; 10: 894128, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36339221

RESUMO

Background: During the COVID-19 pandemic, protective measures have been prescribed to prevent or slow down the spread of the SARS-CoV-2 virus and protect the population. Individuals follow these measures to varying degrees. We aimed to identify factors influencing the extent to which protective measures are adhered to. Methods: A cross-sectional survey (telephone interviews) was undertaken between April and June 2021 to identify factors influencing the degree to which individuals adhere to protective measures. A representative sample of 1,003 people (age >16 years) in two Austrian states (Carinthia, Vorarlberg) was interviewed. The questionnaire was based on the Health Belief Model, but also included potential response-modifying factors. Predictors for adherent behavior were identified using multiple regression analysis. All predictors were standardized so that regression coefficients (ß) could be compared. Results: Overall median adherence was 0.75 (IQR: 0.5-1.0). Based on a regression model, the following variables were identified as significant in raising adherence: higher age (ß = 0.43, 95%CI: 0.33-0.54), social standards of acceptable behavior (ß = 0.33, 95%CI: 0.27-0.40), subjective/individual assessment of an increased personal health risk (ß = 0.12, 95%CI: 0.05-0.18), self-efficacy (ß = 0.06, 95%CI: 0.02-0.10), female gender (ß = 0.05, 95%CI: 0.01-0.08), and low corona fatigue (behavioral fatigue: ß = -0.11, 95%CI: -0.18 to -0.03). The model showed that such aspects as personal trust in institutions, perceived difficulties in adopting health-promoting measures, and individual assessments of the risk of infection, had no significant influence. Conclusions: This study reveals that several factors significantly influence adherence to measures aimed at controlling the COVID-19 pandemic. To enhance adherence, the government, media, and other relevant stakeholders should take the findings into consideration when formulating policy. By developing social standards and promoting self-efficacy, individuals can influence the behavior of others and contribute toward coping with the pandemic.


Assuntos
COVID-19 , Feminino , Humanos , Adolescente , COVID-19/epidemiologia , Pandemias/prevenção & controle , SARS-CoV-2 , Estudos Transversais , Telefone , Fadiga/epidemiologia
18.
Front Public Health ; 10: 973690, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36324454

RESUMO

Introduction: Shift work of clinical faculty members in the COVID-19 pandemic may cause burnout and occupational fatigue and as a result, may reduce the quality of student education and disrupt the treatment of patients, so this study was conducted to evaluate this case. Materials and methods: The statistical population of this cross-sectional research included all clinical faculty members of Ahvaz Jundishapur University of Medical Sciences in southwestern Iran, who experienced a shift work system (night shift from 8 p.m. to 8 a.m.) during the COVID-19 pandemic, and finally, 71 of them participated in it. The sampling method was also available. Two inventories were used to collect data, namely the Maslach Burnout Inventory [MBI-HSS (MP)] and the Swedish Occupational Fatigue Inventory (SOFI-20). Results: The self-reported burnout of faculty members was high (mean ± SD = 98.18 ± 17.18), which was graded into the range of emotional exhaustion (38.01 ± 10.2), range of personal accomplishment, (33.75 ± 6.75), and the range of depersonalization (26.42 ± 3.5), respectively. Perceived occupational fatigue of faculty members was also high (M ± SD = 82.25 ± 34.79), which included the dimensions of lack of motivation (18.69 ± 8.65), drowsiness (17.43 ± 8.7), lack of energy (16.33 ± 7.67), physical discomfort (15.65 ± 8.62), and physical stress (13.51 ± 6.9), respectively. In terms of demographic characteristics, occupational fatigue was significantly more common among women. Discussion and conclusion: The self-reported burnout and occupational fatigue of clinical faculty members due to shift work were reported to be high in this study. Although our knowledge of burnout has advanced in recent years, many gaps in our knowledge still remain. In order for clinical faculty members to properly fulfill their mission to treat patients, educate students, and promote public health, it is necessary to provide all the necessary conditions for their effective activity. Some interventions, such as improving organizational strategies and providing technical solutions, incentives, and occupational facilities, can help reduce or eliminate these problems.


Assuntos
Esgotamento Profissional , COVID-19 , Jornada de Trabalho em Turnos , Humanos , Feminino , Estudos Transversais , COVID-19/epidemiologia , Pandemias , Inquéritos e Questionários , Esgotamento Profissional/epidemiologia , Docentes , Fadiga/epidemiologia
19.
BMJ Open ; 12(11): e065939, 2022 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-36319059

RESUMO

INTRODUCTION: Breast cancer is the most prevalent cancer among women. The treatment is extensive; in addition to surgery, various combinations of radiation therapy, chemotherapy and antibody and endocrine treatment can be applied. Cancer-related fatigue (CRF) is high in patients with breast cancer, peaking during chemotherapy, but may persist for several years. Physical activity has proven to be effective in reducing CRF in breast cancer rehabilitation, but many patients tend to be less active after the diagnosis. Yoga has a previously demonstrated effect on energy levels and digitally distributed yoga intervention can potentially increase accessibility in pandemic times and facilitate participation for patients susceptible to infection and those living far from organised rehabilitation opportunities. The purpose of this study, Digital Yoga Intervention in Cancer Rehabilitation (DigiYoga CaRe) is to investigate whether a 12-week digitally distributed yoga intervention can reduce CRF and stress, improve health-related quality of life (HRQL) and affect pro-inflammatory and metabolic markers in patients with breast cancer. METHODS AND ANALYSIS: This multicentre study will adopt a randomised controlled design including 240 persons after their breast cancer surgery. They will be randomised to a 12-week digitally distributed yoga intervention or to a control group. The intervention group practice yoga two times a week, one yoga class live-streamed to the patient's computer or mobile device and one prerecorded video class for self-training. The controls receive standardised care, gift cards for flowers and access to yoga video links after the data collection has ended. The primary analysis will be performed following the principle of intention to treat. Data will be collected by questionnaires, blood samples, accelerometers and interviews. ETHICS AND DISSEMINATION: The DigiYoga CaRe study was approved by the Regional Ethical Review Board in Lund. The final results of this study will be disseminated to conference, patient and public involvements and peer-reviewed publications. TRIAL REGISTRATION NUMBER: NCT04812652.


Assuntos
Neoplasias da Mama , Yoga , Humanos , Feminino , Qualidade de Vida , Fadiga , Mama , Ensaios Clínicos Controlados Aleatórios como Assunto , Estudos Multicêntricos como Assunto
20.
Arq Neuropsiquiatr ; 80(9): 929-934, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36351418

RESUMO

BACKGROUND: Multiple sclerosis (MS) has a negative effect on employment status. OBJECTIVE: To present the preliminary results of a special questionnaire designed to collect employment information on patients with MS. METHODS: The questionnaire on the impact of MS on employment status was completed by 63 patients. Fatigue, cognition, and depression were also evaluated, and 33 healthy participants were recruited as a control group. RESULTS: Regarding the patients' employment status, we found rates of 31.7% of full-time employment, 28.6% of part-time employment, 7.9% of unemployment due to MS, 4.8% of housewives, 1.6% retirement due to age, 15.9% of retirement due to disability, 7.9% of medical leave due to MS, and 1.6% of medical leave for other reasons. The rate of unemployment among the patients was significantly higher compared with that of the control group. Out of 38 working patients, 31% had been absent from work for the previous 3 months due to MS, and 50% had to make changes in their work to remain employed. Out of the 19 unemployed patients, 78% said that walking difficulties were the cause of unemployment, while 52% thought cognitive impairment was the cause. CONCLUSIONS: The questionnaire provides a record of the employment status of patients with MS and describes the impact on work from their point of view.


ANTECEDENTES: A esclerose múltipla (EM) tem um efeito negativo na situação laboral. OBJETIVO: Apresentar os resultados preliminares de um questionário elaborado para coletar informações sobre a situação laboral de pacientes com EM. MéTODOS: O questionário sobre o impacto da EM na situação laboral foi preenchido por 63 pacientes. Fadiga, cognição e depressão também foram avaliadas, e 33 pacientes saudáveis foram incluídos como grupo controle. RESULTADOS: Quanto à situação laboral dos pacientes, foram encontradas taxas de 31,7% de emprego em tempo integral, 28,6% de emprego em meio período, 7,9% de desemprego por EM, 4,8% de donas de casa, 1,6% aposentadoria por idade, 15,9% de aposentadoria por invalidez, 7,9% por licença médica por EM, e 1,6% de licença médica por outros motivos. A taxa de desemprego entre os pacientes foi significativamente mais alta em comparação com a do grupo controle. Dos 38 pacientes empregados, 31% tiveram que se afastar do trabalho nos 3 meses anteriores por causa da EM, e 50% tiveram que fazer mudanças em seu trabalho para permanecer empregado. Dos 19 pacientes desempregados, 78% mencionaram que as dificuldades de locomoção foram a causa do desemprego, enquanto 52% reportaram que a deterioração cognitiva foi a causa. CONCLUSõES: Este questionário fornece um registro da situação laboral dos pacientes com EM e descreve o seu impacto no emprego do ponto de vista deles.


Assuntos
Pessoas com Deficiência , Esclerose Múltipla , Humanos , Adolescente , Esclerose Múltipla/complicações , Emprego , Inquéritos e Questionários , Fadiga/etiologia
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