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1.
Water Sci Technol ; 80(3): 563-574, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31596267

RESUMO

This study was conducted to evaluate the influence of chloride ions (Cl-) on organic contaminants decolorization by the Fe0-activated persulfate process (PS/Fe0), as well as the generation of transformation products. Orange II (OII) was chosen as the target pollution. The results indicated that Cl- influenced the OII decolorization by PS/Fe0 system, resulting in the generation of chlorine-containing by-products. OII containing Cl- solution can be efficiently decolorized by PS/Fe0 process, and the decolorization efficiencies changed depending on Cl- concentration due to the reaction between Cl- and sulfate radicals (SO4-•). The operating cost for 94% color and 64% chemical oxygen demand (COD) removal of the OII dye was estimated at 0.73 USD/m3. The chlorine-containing by-products, such as chlorobenzene, 3,5-dichloro-benzene-1,2-diol, and 2,3-dichloro-2,3-dihydro-1,4-naphthoquinone, were generated during the reaction. The results further indicated that increasing both PS concentration and temperature enhanced OII decolorization and reduced the generation of chlorine-containing intermediates. The addition of ultrasound can further decrease the generation of chlorine-containing intermediates under high-temperature conditions. The proposed pathways of decolorization of OII containing Cl- also indicated that SO4-• dominated the OII degradation, while the presence of Cl- led to the generation of chlorine-containing intermediates.


Assuntos
Cloretos , Modelos Químicos , Sulfatos , Cor , Ferro/química , Oxirredução
2.
Rinsho Ketsueki ; 60(9): 1092-1099, 2019.
Artigo em Japonês | MEDLINE | ID: mdl-31597832

RESUMO

Previous randomized controlled trials (RCTs) have shown beneficial effects of iron supplementation other than anemia improvement including treatment of restless leg syndrome and general fatigue, even in non-anemic subjects with iron deficiency. Recently, some RCTs in congestive heart failure (CHF) demonstrated that intravenous administration of ferric carboxymaltose improves patient symptoms and reduces incidence of hospitalization for worsening heart failure. Consequently, the European Society of Cardiology recommends that iron deficient patients with CHF are administered ferric carboxymaltose (evidence level A). Moreover, the PIVOTAL study for hemodialysis patients proved that proactive administration of iron sucrose decreases the dose of erythropoiesis-stimulating agents and frequency of transfusion compared with its sole administration in reaction to iron deficiency. Notably, this proactive treatment is superior to a low-dose regimen in preventing the primary composite endpoints of nonfatal myocardial infarction, stroke, hospitalization for CHF, and death. These clinical findings are supported by basic research on cardiomyocyte-specific transferrin receptor knock-out mice showing heart failure with impaired mitochondrial respiratory function. In this model, cardiac iron deficiency impairs the mitochondrial electron transport chain, thus leading to low adenosine triphosphate production, and it subsequently prevents mitophagy resulting in damaged mitochondrial accumulation in the heart.


Assuntos
Insuficiência Cardíaca/tratamento farmacológico , Ferro/administração & dosagem , Administração Intravenosa , Anemia Ferropriva , Animais , Compostos Férricos/administração & dosagem , Óxido de Ferro Sacarado/administração & dosagem , Humanos , Maltose/administração & dosagem , Maltose/análogos & derivados , Camundongos , Ensaios Clínicos Controlados Aleatórios como Assunto , Receptores da Transferrina/genética
3.
J Environ Qual ; 48(5): 1549-1556, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31589739

RESUMO

We report a preliminary assessment of ferrate [Fe(VI)] for the treatment of acid mine drainage (AMD), focused on precipitation of metals (i.e., iron [Fe] and manganese [Mn]) and subsequent removal. Two dosing approaches were studied to simulate the two commercially viable forms of Fe(VI) production: Fe(VI) only, and Fe(VI) with sodium hydroxide (NaOH). Subsequent metal speciation was assessed via filter fractionation. When only Fe(VI) was added, the pH remained <3.6, and the precipitation of Mn and Fe was <30 and <70%, respectively, at the highest, stoichiometrically excessive Fe(VI) dose. When NaOH and Fe(VI) were added simultaneously, precipitation of Mn was much more complete, at doses near the predicted oxidation stoichiometric requirement. The optimal dosage of Fe(VI) for Mn treatment was 25 µM. The formation of Mn(VII) was noted at Fe(VI) dosages above the stoichiometric requirement, which would be problematic in full-scale AMD treatment systems. Precipitation of Fe was >99% when only NaOH was added, indicating that oxidation by Fe(VI) did not play a significant role when added. The Fe(III) and Al(III) particles were relatively large, suggesting probable success in subsequent removal through sedimentation. Resultant Mn-oxide particles were relatively small, indicating that additional particle destabilization may be required to meet Mn effluent goals. Ferrate seems viable for the treatment of AMD, especially when sourced through onsite generation due to the coexistence of NaOH in the product stream. More research on the use of Fe(VI) for AMD treatment is required to answer extant questions.


Assuntos
Compostos Férricos , Ferro , Manganês , Mineração , Oxirredução
4.
Arq Bras Cir Dig ; 32(3): e1453, 2019.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31644673

RESUMO

BACKGROUND: : Bariatric surgery promotes significant weight loss and improvement of associated comorbidities; however, nutrients deficiencies and weight regain may occur in the middle-late postoperative period. AIM: To investigate nutritional status in 10 years follow-up. METHODS: : Longitudinal retrospective study in which anthropometric, biochemical indicators and nutritional intake were assessed before and after one, two, three, four, five and ten years of Roux-en Y gastric bypass through analysis of medical records. RESULTS: : After ten years there was a reduction of 29.2% of initial weight; however, 87.1% of patients had significant weight regain. Moreover, there was an increase of incidence of iron (9.2% to 18.5%), vitamin B12 (4.2% to 11.1%) and magnesium deficiency (14.1% to 14.8%). Folic acid concentrations increased and the percentage of individuals with glucose (40.4% to 3.7%), triglycerides (38% to 7.4%), HDL cholesterol (31 % to 7.4%) and uric acid (70.5% to 11.1%) abnormalities reduced. Also, there is a reduction of food intake at first year postoperative. After 10 years, there was an increase in energy, protein and lipid intake, also a reduction in folid acid intake. CONCLUSIONS: : Roux-en Y gastric bypass is an effective procedure to promote weight loss and improve comorbidities associated with obesity. However, comparison between postoperative period of five and 10 years showed a high prevalence of minerals deficiency and a significant weight regain, evidencing the need for nutritional follow-up in the postoperative period.


Assuntos
Derivação Gástrica/reabilitação , Estado Nutricional/genética , Obesidade/cirurgia , Fenótipo , Adulto , Índice de Massa Corporal , Feminino , Ácido Fólico/sangue , Seguimentos , Humanos , Ferro/sangue , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Transtornos Nutricionais/sangue , Transtornos Nutricionais/etiologia , Obesidade/complicações , Período Pós-Operatório , Estudos Retrospectivos , Resultado do Tratamento , Vitamina B 12/sangue , Perda de Peso
6.
Waste Manag ; 100: 1-9, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31493683

RESUMO

Eddy current separation (ECS) is an environment-friendly technology for separating nonferrous metallic particles whose size was from 2 mm to 10 mm. No wastes are generated in ECS. ECS quality of nonferrous metals from solid wastes is rather low in the production practice of spent lithium iron phosphate (LFP) batteries recovering. Repeating separation even manual sorting is required in the production. The traditional method of falling point prediction based on eddy current mechanics uses equivalent acceleration to replace separation motion curves. These curves have low precision and are unsuitable for predicting the motion trajectory of small particle size of sorted materials. In this work, eddy current separation of positive and negative plates in a crushed product of spent lithium iron phosphate battery is used as an example to establish the force and kinematics models of different materials in the eddy current separation. An iterative method, rather than average speed method, is used to improve the accuracy of the model. Displacement interval replaces disengagement angle as a separating index to improve the model's intuitiveness and practical guidance. In the range of 2-20 mm, test results are consistent with simulation results. The copper and aluminium foils at a magnetic roller speed of 800r/min can be separated to a maximum particle size ratio of 1.72, and the maximum particle size ratio of copper and positive electrode sheets can be large. This paper provided an environmental-friendly and effective technology for separating nonferrous metals from crushed spent LFP batteries.


Assuntos
Lítio , Reciclagem , Fontes de Energia Elétrica , Ferro , Fosfatos
7.
Water Sci Technol ; 80(2): 223-231, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31537758

RESUMO

In this study, we use an anaerobic-aerobic integrated denitrification (Fe/C-ZACID) device with an iron-carbon-activated carbon and zeolite composite filter to remove nitrogen from simulated low carbon-nitrogen ratio (C/N) sewage. The impacts of dissolved oxygen (DO) level, hydraulic retention time (HRT), C/N and nitrate recirculation ratio on denitrification performance were studied. The results show that when HRT was 6 h, DO was 3 ± 0.1 mg/L, influent C/N was 3, and nitrate recirculation ratio was 100%, and removal rates of 95% for ammonia and 85% for total nitrogen (TN) were achieved. A beaker comparison test demonstrated that this synergistic denitrification system included heterotrophic denitrification, physicochemical denitrification, iron autotrophic denitrification and hydrogen autotrophic denitrification, etc. The Fe/C-ZACID device has a high-efficiency nitrogen removal effect for low C/N ratio sewage and strong shock resistance, which provides technical support and a theoretical basis for advanced denitrification of rural domestic sewage.


Assuntos
Desnitrificação , Eliminação de Resíduos Líquidos/métodos , Zeolitas , Anaerobiose , Reatores Biológicos , Carvão Vegetal , Filtração , Ferro , Nitrogênio , Esgotos
8.
Braz Oral Res ; 33: e055, 2019 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-31531562

RESUMO

Serum hepcidin levels may increase in response to infection and inflammation. The present study investigated the effect of nonsurgical periodontal therapy (NSPT) on levels of serum hepcidin, inflammatory markers, and iron markers. An interventional study was conducted on 67 patients (age 30-65 years) without other diseases, except for chronic periodontitis (CP). Patients were allocated to either CP or control groups. The CP group received supragingival and subgingival scaling and root planing procedures, whereas the control group received supragingival scaling. Probing depth (PD), bleeding on probing, clinical attachment level (CAL), visible plaque index (VPI), serum hepcidin and interleukin-6 (IL-6) levels, high-sensitivity C-reactive protein (hs-CRP), hematological markers, and iron markers were measured at baseline and at 90 days after NSPT. The CP group had statistically significant lower mean values for mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) (p ≤ 0.05). The control group had statistically significant reductions in hemoglobin, hematocrit, MCV, and MCH (p ≤ 0.05). Serum hepcidin, IL-6, and erythrocyte sedimentation rate (ESR) levels were significantly decreased in both groups after NSPT. Periodontal markers were more markedly reduced in the CP group compared with the control group (p ≤ 0.05). These findings suggest that NSPT may reduce the serum levels of IL-6, hepcidin, and periodontal parameters.


Assuntos
Periodontite Crônica/sangue , Hepcidinas/sangue , Ferro/sangue , Adulto , Biomarcadores/sangue , Proteína C-Reativa/análise , Estudos de Casos e Controles , Periodontite Crônica/patologia , Periodontite Crônica/terapia , Índice de Placa Dentária , Feminino , Gengiva/patologia , Humanos , Interleucina-6/sangue , Masculino , Pessoa de Meia-Idade , Perda da Inserção Periodontal/sangue , Perda da Inserção Periodontal/patologia , Valores de Referência , Aplainamento Radicular/métodos , Estatísticas não Paramétricas , Fatores de Tempo , Resultado do Tratamento
10.
Bioresour Technol ; 293: 122051, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31472405

RESUMO

In this work, a 30-days batched mesophilic assay on pretreated food waste (PFW) under different inoculum/substrate (I/S) ratios (1:5, 1:2, 1:1, 2:1, 4:1 and 1:0) was carried out, to target the most important parameters in AD matrix on regulating iron (Fe) chemical speciation. Correlation coefficients were calculated within four Fe chemical forms and AD parameters of pH, volatile fatty acids (VFAs), inorganic acid radicals (IARs), and alkalinity. Results showed that IARs were not key factors on regulating Fe speciation. Without acidification, IARs showed weak correlations (coefficients < 0.40) with Fe chemical dynamics while other parameters showed stronger correlations (coefficients ≥ 0.60). Under acidification, VFAs initiated the conversion of exchangeable Fe into water soluble fraction. Residual fraction might play important role in regulating Fe shifting to more bioavailable states.


Assuntos
Ácidos Graxos Voláteis , Ferro , Anaerobiose , Reatores Biológicos , Alimentos
11.
Bioresour Technol ; 293: 122003, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31476567

RESUMO

Aquaculture wastewater seriously threatens the human health. In this study, non-poisonous iron was added into constructed wetlands to purify aquaculture wastewater and the wastewater treatment performances of CWs were explored under the treatment conditions of different plant species and different dosages of ferrous ions. The optimal treatment conditions were experimentally determined as follows: 20 mg/L ferrous ions in CWs planted with Canna indica after 7-day operation, the removal efficiencies of TN, TP and COD were respectively 95 ±â€¯1.9%, 77 ±â€¯1.2% and 62 ±â€¯2%. The improvements in the pollutant removal performance depended on biological mechanisms of plants and microorganisms. The optimal dosage of iron ions could adjust enzyme activities and functional amino acids. Specific functional bacteria (Paracoccus detected based on nirK genetic information and Hydrogenophaga detected based on pufM genetic information) were cultured and domesticated by iron ions. The functional bacteria promoted nitrogen and phosphorus removals.


Assuntos
Poluentes Ambientais , Águas Residuárias , Aquicultura , Ferro , Nitrogênio , Eliminação de Resíduos Líquidos , Áreas Alagadas
12.
Bioresour Technol ; 293: 122088, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31499331

RESUMO

This study presented an innovative method for phosphorus (P) recovery as vivianite from waste activated sludge (WAS) via optimizing iron dosing and pH value during anaerobic fermentation (AF). The optimal conditions for vivianite formation were in the pH range of 6.0-9.0 with initial PO43- >5 mg/L and Fe/P molar ratio of 1.5. Notably, FeCl3 showed advantages over ZVI for the simultaneous release of Fe2+ and PO43- during WAS fermentation, especially in acidic conditions. The FeCl3 dosing at pH 3.0 could contribute to 78.81% Fe2+ release and 85.69% of total PO43- release from WAS. They were ultimately recovered in the form of high-purity vivianite (93.67%). Clostridiaceae (40.25%) was the predominant bacteria in FeCl3-pH3 reactors, which played key roles in inducing dissimilatory iron reduction for Fe2+ formation. Therefore, P recovery as vivianite from WAS fermentation might be a promising and highly valuable approach to relieve the P crisis.


Assuntos
Fósforo , Esgotos , Anaerobiose , Fermentação , Compostos Ferrosos , Concentração de Íons de Hidrogênio , Ferro , Fosfatos , Eliminação de Resíduos Líquidos
13.
Bioresour Technol ; 293: 122092, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31505392

RESUMO

The effects of nanoscale zero-valent iron (nZVI) on the performance of food waste anaerobic digestion and the fate of antibiotic resistance genes (ARGs) were investigated in thermophilic (TR) and mesophilic (MR) reactors. Results showed that nZVI enhanced biogas production and facilitated ARGs reduction. The maximum CH4 production was 212.00 ±â€¯4.77 ml/gVS with 5 g/L of nZVI in MR. The highest ARGs removal ratio was 86.64 ±â€¯0.72% obtained in TR at nZVI of 2 g/L. nZVI corrosion products and their contribution on AD performance were analyzed. The abundance of tetracycline genes reduced significantly in nZVI amended digesters. Firmicutes, Chloroflexi, Proteobacteria and Spirochaetes showed significant positive correlations with various ARGs (p < 0.05) in MR and TR. Redundancy analysis indicated that microbial community was the main factor that influenced the fate of ARGs. nZVI changed microbial communities, with decreasing the abundance bacteria belonging to Firmicutes and resulting in the reduction of ARGs.


Assuntos
Antibacterianos , Ferro , Anaerobiose , Bactérias , Resistência Microbiana a Medicamentos
14.
Klin Lab Diagn ; 64(8): 477-480, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31479602

RESUMO

This research paper presents the results of a study of some indicators of iron metabolism in anaemia in pregnant women. The venous blood of 39 pregnant women with anaemia was examined. Serum ferritin, ferroportin and hepcidin were investigated for this purpose. The comparison group consisted of 19 pregnant women without anaemia. The haemoglobin concentration was measured by using «Mythic-18¼ haematological autoanalyzer. The concentrations of hepcidin and ferroportin were determined by using «Cloud-Clone Corp.¼ (USA), and ferritin concentrations were determined by using «Pishtaz teb¼ (Iran) reagents through enzyme-linked immunosorbent assay (ELISA) method. The study revealed a significant decrease in the level of ferritin, hepcidin and a significant increase in ferroportin level. A comprehensive definition of various indicators of iron metabolism provides important information not only for understanding the pathogenesis of iron deficiency anaemia in pregnant women but also for early diagnosis of the disease and the appointment of the correct treatment.


Assuntos
Anemia Ferropriva/sangue , Citocinas/sangue , Ferro/metabolismo , Complicações Hematológicas na Gravidez/sangue , Feminino , Ferritinas/sangue , Hepcidinas/sangue , Humanos , Gravidez
15.
Niger J Clin Pract ; 22(8): 1132-1139, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31417058

RESUMO

Background: The International Nutritional Anaemia Consultative Group has recommended a twice daily dose of 65 mg elemental iron supplementation in pregnant women living in areas where anaemia is prevalent contrary to the World Health Organization (WHO) universal recommendation of a daily dose of 60 mg. Whether twice or daily dose schedules proffer a better outcome is a subject of on-going research. Objective: To compare the effectiveness of the once versus twice daily doses of ferrous sulphate in the prevention of iron deficiency anaemia in pregnancy. Methods: There are about one hundred and eighty two (182) pregnant women at gestational ages of 14-24 weeks with haemoglobin (Hb) levels ≥10 g/dl but ≤14.5 g/dl were recruited during the antenatal booking clinic. They were randomized into receiving either once daily dose (65 mg of elemental iron) or twice daily dose (130 mg of elemental iron) of ferrous sulphate. Pre and post- supplementation haemoglobin, serum iron and ferritin levels were assessed at recruitment and at 37 weeks gestation respectively. Results: Eighty-four (84) and 80 women respectively in the once and twice daily dose groups were analysed. The serum haemoglobin was significantly lower (P = 0.002) among those on once daily than those on twice daily supplementation. The side effects were however, significantly higher in the twice daily group (P = 0.005, P = 0.043 and P = 0.004 respectively). There were no differences between the serum ferritin levels pre and post supplementation in both groups just as they were no reported significant differences in both birth weight of neonates (P = 0.936) and average gestational age at delivery (P = 0.469) between the two groups. Conclusion: Once daily (65 mg elemental iron) ferrous sulphate is as effective as twice daily (130 mg elemental iron) dose regimen in prevention of Anaemia in pregnancy in a developing economy like Nigeria. Once daily dose possesses fewer side effects and guarantees better compliance in this study.


Assuntos
Anemia Ferropriva/prevenção & controle , Compostos Ferrosos/administração & dosagem , Complicações Hematológicas na Gravidez/prevenção & controle , Adulto , Suplementos Nutricionais , Esquema de Medicação , Feminino , Ferritinas/sangue , Compostos Ferrosos/uso terapêutico , Hemoglobinas/análise , Humanos , Recém-Nascido , Ferro/sangue , Nigéria , Gravidez , Terceiro Trimestre da Gravidez , Gestantes , Resultado do Tratamento , Adulto Jovem
16.
Int J Nanomedicine ; 14: 4637-4648, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31417259

RESUMO

Aim: It has been indicated that NPs may change the amyloidogenic steps of proteins and relevant cytotoxicity. Therefore, this report assigned to explore the impact of ZVFe NPs on the amyloidogenicity and cytotoxicity of α-synuclein as one of the many known amyloid proteins. Methods: The characterization of α-synuclein at amyloidogenic condition either alone or with ZVFe NPs was carried out by fluorescence, CD, UV-visible spectroscopic methods, TEM study, docking, and molecular modeling. The cytotoxicity assay of α-synuclein amyloid in the absence and presence of ZVFe NPs was also done by MTT, LDH, and flow cytometry analysis. Results: ThT fluorescence spectroscopy revealed that ZVFe NPs shorten the lag phase and accelerate the fibrillation rate of α-synuclein. Nile red and intrinsic fluorescence spectroscopy, CD, Congo red adsorption, and TEM studies indicated that ZVFe NP increased the propensity of α-synuclein into the amyloid fibrillation. Molecular docking study revealed that hydrophilic residues, such as Ser-9 and Lys-12 provide proper sites for hydrogen bonding and electrostatic interactions with adsorbed water molecules on ZVFe NPs, respectively. Molecular dynamics study determined that the interacted protein shifted from a natively discorded conformation toward a more packed structure. Cellular assay displayed that the cytotoxicity of α-synuclein amyloid against SH-SY5Y cells in the presence of ZVFe NPs is greater than the results obtained without ZVFe NPs. Conclusion: In conclusion, the existence of ZVFe NPs promotes α-synuclein fibrillation at amyloidogenic conditions by forming a potential template for nucleation, the growth of α-synuclein fibrillation and induced cytotoxicity.


Assuntos
Amiloide/metabolismo , Ferro/química , Nanopartículas Metálicas/química , alfa-Sinucleína/metabolismo , Amiloide/química , Benzotiazóis/química , Morte Celular , Linhagem Celular Tumoral , Vermelho Congo/química , Humanos , Cinética , L-Lactato Desidrogenase/metabolismo , Simulação de Acoplamento Molecular , Simulação de Dinâmica Molecular , Oxazinas/química , Agregados Proteicos , Estrutura Secundária de Proteína , Espectrometria de Fluorescência , Tirosina/química , alfa-Sinucleína/química , alfa-Sinucleína/ultraestrutura
17.
Artigo em Russo | MEDLINE | ID: mdl-31465663

RESUMO

Anemia is a clinical hematological syndrome and also a risk factor for the adverse outcome of many chronic somatic diseases. To assess effectiveness of out-patient polyclinic care for patients with anemia, the computer program "Patient Monitoring System with Anemic Syndrome" was used. The study included 1498 patients (males - 491; females - 1007) aged from 18 to 80 years old, who were under medical observation by general practitioners. The prevalence of anemic syndrome in different age and gender groups varied from 11 to 58%. Statistically significant differences between subgroups of men and women were found in the categories 18-30 years, 31-40 years and 41-50 years. In adult patients of working age, anemic syndrome during routine examination was detected in 37% of cases of seeking outpatient medical care (anemic syndrome in women was three times more common than in men). In patients older than working age, the prevalence of anemic syndrome was lower and averaged 25.7%. In the structure of anemia, 48.4% are hypochromic, 5.4% are hyperchromic, 46.2% are normochromic. The study for serum iron was prescribed in 33.9% of cases of hypochromic anemia, in 22.5% of cases of normochromic anemia and in 11.1% of cases of hyperchromic anemia. Serum iron was detected in every second patient with diseases of the urogenital system, every third patient with neoplasm. Therapy with iron preparations was prescribed in 30.6%, and the administration of vitamin B12 - in 1.4% of cases.


Assuntos
Assistência Ambulatorial , Anemia Ferropriva/epidemiologia , Sistema de Registros , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Anemia , Feminino , Humanos , Ferro , Masculino , Pessoa de Meia-Idade , Adulto Jovem
18.
J Agric Food Chem ; 67(36): 10126-10136, 2019 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-31433635

RESUMO

Soil microbes have recently been utilized to improve cadmium (Cd) tolerance and lower its accumulation in plants. Nevertheless, whether rhizobacteria can prevent Cd uptake by graminaceous plants and the underlying mechanisms remain elusive. In this study, inoculation with Enterobacter asburiae NC16 reduced transpiration rates and the expression of some iron (Fe) uptake-related genes including ZmFer, ZmYS1, ZmZIP, and ZmNAS2 in maize (Zea mays) plants, which contributed to mitigation of Cd toxicity. However, the inoculation with NC16 failed to suppress the transpiration rates and transcription of these Fe uptake-related genes in plants treated with fluridone, an abscisic acid (ABA) biosynthetic inhibitor, indicating that the impacts of NC16-inoculation observed were dependent on the actions of ABA. We found that NC16 increased the host ABA levels by mediating the metabolism of ABA rather than its synthesis. Moreover, the capacity of NC16 to inhibit plant uptake of Cd was greatly weakened in plants overexpressing ZmZIP, encoding a zinc/iron transporter. Collectively, our findings indicated that E. asburiae NC16 reduced Cd toxicity in maize plants at least partially by hampering the Fe uptake-associated pathways.


Assuntos
Cádmio/metabolismo , Enterobacter/metabolismo , Ferro/metabolismo , Zea mays/metabolismo , Inoculantes Agrícolas/metabolismo , Transporte Biológico/efeitos dos fármacos , Proteínas de Transporte de Cátions/genética , Proteínas de Transporte de Cátions/metabolismo , Regulação da Expressão Gênica de Plantas , Proteínas de Plantas/genética , Proteínas de Plantas/metabolismo , Raízes de Plantas/metabolismo , Raízes de Plantas/microbiologia , Piridonas/farmacologia , Zea mays/efeitos dos fármacos , Zea mays/genética , Zea mays/microbiologia
19.
Oecologia ; 191(1): 51-60, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31428869

RESUMO

The availability of iron (Fe) varies considerably among diet items, as well as ecosystems. Availability of Fe has also changed due to anthropogenic environmental changes in oceanic as well as inland ecosystems. We know little about its role in the nutrition of ecologically important consumers, particularly in inland ecosystems. Physiological studies in several taxa indicate marked effects of dietary Fe on oogenesis. We predicted that differential Fe supply to algae will impact algal Fe concentration with consequences on the life history of the freshwater grazer, Daphnia magna. We found that algal Fe concentration increased with Fe supply, but did not affect algal growth, indicating that the majority of experimental Fe additions were likely adsorbed to, or stored in algal cells. Regardless, data indicate that algal Fe impacted the reproductive traits (age and size at maturity) but not juvenile growth rate of Daphnia. A subsequent experiment revealed that Fe concentration in eggs was significantly higher than the rest of Daphnia. These results indicate that the concentration of Fe in or on algal cells may vary considerably among ecosystems overlying distinct geological formations differing in Fe, possibly with important implications for zooplankton life histories. Understanding the mechanisms underlying this response is unlikely to be accomplished by a strict focus on Fe because we found correlated shifts in the algal ionome, with concomitant ionome-wide adjustments in Daphnia. Information on ionome-wide responses may be useful in better understanding the responses of biota to changes in the supply of any one element.


Assuntos
Daphnia , Ecossistema , Animais , Ferro , Oceanos e Mares , Zooplâncton
20.
Pan Afr Med J ; 33: 48, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31448011

RESUMO

Introduction: diagnostic methods and management of iron deficiency and iron deficiency anemia in clinical practice in Algeria is poorly known. Methods: we conducted a cross-sectional survey among doctors in different specialties treating patients with iron deficiency anemia in 2016. Results: data analysis was based on 349 questionnaires which were validated (anesthesia/resuscitation: 39; obstetrics and gynaecology: 111; oncology/Hematology: 71; hepato-gastroenterology: 64; cardiology: 36; internal medicine: 28). All specialties combined, 73% (254/349) of physicians thought that at least 30% of their patients had iron deficiency anemia; 65% of physicians (226/349) thought that at least 30% of their patients had iron deficiency. Iron deficiency was investigated systematically by 57% (63/111) of physicians of the group obstetrics and gynaecology, but only by 11% (26/238) of the remaining doctors; indeed, 82% (195/238) of physicians investigated it only in patients with anemia. The assessment of iron deficiency showed that the hemoglobin (Hb) was almost always determined (89%; 310/349) while laboratory tests to explore iron metabolism were inadequate: 70% (244/349) of physicians performed serum ferritin test and only 37% (128/349) performed transferrin saturation. Patients with iron deficiency (with or without anemia) received oral iron therapy (prescribed by 92% (322/349) of physicians) and iron injections therapy depending on Hb level (prescribed by 36% (127/349) of physicians). Conclusion: this survey shows that iron deficiency is evaluated only in patients with anemia. In particular, laboratory tests to measure iron deficiency are insufficiently prescribed.


Assuntos
Anemia Ferropriva/diagnóstico , Ferro/deficiência , Médicos/estatística & dados numéricos , Padrões de Prática Médica/estatística & dados numéricos , Adulto , Argélia , Anemia/diagnóstico , Anemia/terapia , Anemia Ferropriva/terapia , Estudos Transversais , Feminino , Ferritinas/sangue , Pesquisas sobre Serviços de Saúde , Hemoglobinas/análise , Humanos , Ferro/administração & dosagem , Masculino , Pessoa de Meia-Idade , Adulto Jovem
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