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1.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 880-883, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018125

RESUMO

Parkinson's disease (PD) is characterized by excessively synchronized neural activity. In this paper, we recorded electrophysiological signals in Cortex of normal and PD mode monkey using homemade implantable microelectrode arrays (MEA), and analyzed the characteristics of action potentials (APs) and local field potentials (LFPs). Results showed that, comparing to normal monkey, the spike-firing activity of PD mode monkey could be divided into two stages: the continuous spike-firing stage and the burst spike-firing stage. The continuous spike-firing lasted for about 20s and oscillated at low frequency about 0.03Hz. APs fired in a burst mode between two continuous discharges. In the continuous spike-firing stage, the spike-firing activity was related to the ripple rhythm (100-200Hz) of LFPs with a coherence 0.86, while, in the burst spike-firing stage, it was related to the phase of theta rhythm (4-7 Hz). APs tended to discharge in the valley of theta rhythm (average peak phase is -10°).Clinical Relevance- This article can provide some references for the study of PD neuropathology.


Assuntos
Doença de Parkinson , Potenciais de Ação , Animais , Córtex Cerebral , Haplorrinos , Microeletrodos
2.
PLoS Comput Biol ; 16(9): e1008164, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32877405

RESUMO

The majority of neurons in primary visual cortex respond selectively to bars of light that have a specific orientation and move in a specific direction. The spatial and temporal responses of such neurons are non-separable. How neurons accomplish that computational feat without resort to explicit time delays is unknown. We propose a novel neural mechanism whereby visual cortex computes non-separable responses by generating endogenous traveling waves of neural activity that resonate with the space-time signature of the visual stimulus. The spatiotemporal characteristics of the response are defined by the local topology of excitatory and inhibitory lateral connections in the cortex. We simulated the interaction between endogenous traveling waves and the visual stimulus using spatially distributed populations of excitatory and inhibitory neurons with Wilson-Cowan dynamics and inhibitory-surround coupling. Our model reliably detected visual gratings that moved with a given speed and direction provided that we incorporated neural competition to suppress false motion signals in the opposite direction. The findings suggest that endogenous traveling waves in visual cortex can impart direction-selectivity on neural responses without resort to explicit time delays. They also suggest a functional role for motion opponency in eliminating false motion signals.


Assuntos
Modelos Neurológicos , Percepção de Movimento/fisiologia , Córtex Visual , Animais , Gatos , Biologia Computacional , Simulação por Computador , Haplorrinos , Orientação Espacial/fisiologia , Córtex Visual/citologia , Córtex Visual/fisiologia
3.
PLoS Comput Biol ; 16(9): e1008165, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32941457

RESUMO

Combining information from multiple sources is a fundamental operation performed by networks of neurons in the brain, whose general principles are still largely unknown. Experimental evidence suggests that combination of inputs in cortex relies on nonlinear summation. Such nonlinearities are thought to be fundamental to perform complex computations. However, these non-linearities are inconsistent with the balanced-state model, one of the most popular models of cortical dynamics, which predicts networks have a linear response. This linearity is obtained in the limit of very large recurrent coupling strength. We investigate the stationary response of networks of spiking neurons as a function of coupling strength. We show that, while a linear transfer function emerges at strong coupling, nonlinearities are prominent at finite coupling, both at response onset and close to saturation. We derive a general framework to classify nonlinear responses in these networks and discuss which of them can be captured by rate models. This framework could help to understand the diversity of non-linearities observed in cortical networks.


Assuntos
Potenciais de Ação/fisiologia , Modelos Neurológicos , Rede Nervosa/citologia , Rede Nervosa/fisiologia , Neurônios/fisiologia , Animais , Encéfalo/citologia , Encéfalo/fisiologia , Biologia Computacional , Haplorrinos , Camundongos , Dinâmica não Linear
4.
Proc Natl Acad Sci U S A ; 117(29): 17359-17368, 2020 07 21.
Artigo em Inglês | MEDLINE | ID: mdl-32636265

RESUMO

Sleep disorders are among the most debilitating comorbidities of Parkinson's disease (PD) and affect the majority of patients. Of these, the most common is insomnia, the difficulty to initiate and maintain sleep. The degree of insomnia correlates with PD severity and it responds to treatments that decrease pathological basal ganglia (BG) beta oscillations (10-17 Hz in primates), suggesting that beta activity in the BG may contribute to insomnia. We used multiple electrodes to record BG spiking and field potentials during normal sleep and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism in nonhuman primates. MPTP intoxication resulted in severe insomnia with delayed sleep onset, sleep fragmentation, and increased wakefulness. Insomnia was accompanied by the onset of nonrapid eye movement (NREM) sleep beta oscillations that were synchronized across the BG and cerebral cortex. The BG beta oscillatory activity was associated with a decrease in slow oscillations (0.1-2 Hz) throughout the cortex, and spontaneous awakenings were preceded by an increase in BG beta activity and cortico-BG beta coherence. Finally, the increase in beta oscillations in the basal ganglia during sleep paralleled decreased NREM sleep, increased wakefulness, and more frequent awakenings. These results identify NREM sleep beta oscillation in the BG as a neural correlate of PD insomnia and suggest a mechanism by which this disorder could emerge.


Assuntos
Gânglios da Base/fisiopatologia , Doença de Parkinson/complicações , Distúrbios do Início e da Manutenção do Sono/complicações , Sono/fisiologia , 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina/efeitos adversos , Animais , Ritmo beta/fisiologia , Córtex Cerebral/patologia , Haplorrinos , Humanos , Doença de Parkinson/fisiopatologia , Distúrbios do Início e da Manutenção do Sono/fisiopatologia , Vigília
5.
BMC Evol Biol ; 20(1): 70, 2020 06 19.
Artigo em Inglês | MEDLINE | ID: mdl-32560628

RESUMO

BACKGROUND: Lipids contained in milk are an essential source of energy and structural materials for a growing neonate. Furthermore, lipids' long-chain unsaturated fatty acid residues can directly participate in neonatal tissue formation. Here, we used untargeted mass spectrometric measurements to assess milk lipid composition in seven mammalian species: humans, two macaque species, cows, goats, yaks, and pigs. RESULTS: Analysis of the main milk lipid class, triacylglycerides (TAGs), revealed species-specific quantitative differences in the composition of fatty acid residues for each of seven species. Overall, differences in milk lipid composition reflect evolutionary distances among species, with each species group demonstrating specific lipidome features. Among them, human milk contained more medium and long-chain unsaturated fatty acids compared to other species, while pig milk was the most distinct, featuring the highest proportion of long-chain polyunsaturated fatty acids. CONCLUSIONS: We show that milk lipidome composition is dynamic across mammalian species, changed extensively in pigs, and contains features particular to humans.


Assuntos
Lipidômica , Leite/metabolismo , Animais , Bovinos , Ácidos Graxos/química , Ácidos Graxos/metabolismo , Feminino , Haplorrinos , Humanos , Lactação , Especificidade da Espécie , Suínos
6.
PLoS Biol ; 18(6): e3000735, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32530924

RESUMO

Helping a friend move house, donating to charity, volunteering assistance during a crisis. Humans and other species alike regularly undertake prosocial behaviors-actions that benefit others without necessarily helping ourselves. But how does the brain learn what acts are prosocial? Basile and colleagues show that removal of the anterior cingulate cortex (ACC) prevents monkeys from learning what actions are prosocial but does not stop them carrying out previously learned prosocial behaviors. This highlights that the ability to learn what actions are prosocial and choosing to perform helpful acts may be distinct cognitive processes, with only the former depending on ACC.


Assuntos
Giro do Cíngulo , Recompensa , Animais , Haplorrinos , Humanos , Aprendizagem
7.
Parasitol Res ; 119(8): 2703-2711, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32537718

RESUMO

It is known that the current treatment for toxoplasmosis causes side effects. Thus, it is essential to develop new therapies with reduced adverse effects while concurrently maintaining broad coverage and prophylactic therapy. Melatonin is a hormone that participates in the circadian cycle in vertebrates and has antioxidant, immunomodulatory, and antitumoral functions. In addition, it has been shown that melatonin can modulate immune responses and parasitic development during infection by Trypanosoma cruzi and Leishmania spp. Furthermore, studies indicate that melatonin increases the number of lymphocytes in rats infected by Toxoplasma gondii. However, there is no information on the possible effects of melatonin in T. gondii-infected host cells in vitro. This study analyzed the effects of melatonin treatment in the monkey kidney cell epithelial cell line, LLC-MK2, after infection with T. gondii. LLC-MK2 cells were infected and treated/not treated with melatonin, and the infection index was then quantified. Melatonin treatment did not alter host cell viability and was able to reduce parasite proliferation in LLC-MK2 cells at 24 and 48 h and at 6 days. Analysis by scanning electron microscopy confirmed reduction of parasite proliferation and alterations of tachyzoite shapes. Transmission electron microscopy images showed parasites with ruptured plasma membranes and cytoplasmic leakage. After treatment, parasites showed positive staining for apoptotic-like cell death. These results suggest that the use of melatonin as the lead compound for the synthesis of new compounds may constitute an alternative treatment for toxoplasmosis.


Assuntos
Coccidiostáticos/farmacologia , Melatonina/farmacologia , Toxoplasma/efeitos dos fármacos , Toxoplasma/crescimento & desenvolvimento , Animais , Morte Celular/efeitos dos fármacos , Linhagem Celular , Membrana Celular/efeitos dos fármacos , Células Epiteliais/parasitologia , Haplorrinos , Estágios do Ciclo de Vida/efeitos dos fármacos
8.
Cell Res ; 30(9): 794-809, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32546764

RESUMO

Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders, including COVID-19. However, there are still no effective drugs to treat lung injury and fibrosis. In this study, we report the generation of clinical-grade human embryonic stem cells (hESCs)-derived immunity- and matrix-regulatory cells (IMRCs) produced under good manufacturing practice requirements, that can treat lung injury and fibrosis in vivo. We generate IMRCs by sequentially differentiating hESCs with serum-free reagents. IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells (UCMSCs), such as higher expression levels of proliferative, immunomodulatory and anti-fibrotic genes. Moreover, intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury, and significantly improves the survival rate of the recipient mice in a dose-dependent manner, likely through paracrine regulatory mechanisms. IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone, with an excellent efficacy and safety profile in mice and monkeys. In light of public health crises involving pneumonia, acute lung injury and acute respiratory distress syndrome, our findings suggest that IMRCs are ready for clinical trials on lung disorders.


Assuntos
Células-Tronco Embrionárias Humanas/imunologia , Lesão Pulmonar/terapia , Pulmão/patologia , Transplante de Células-Tronco Mesenquimais , Células-Tronco Mesenquimais/imunologia , Animais , Células Cultivadas , Feminino , Fibrose , Haplorrinos , Células-Tronco Embrionárias Humanas/citologia , Humanos , Imunidade , Imunomodulação , Pulmão/imunologia , Lesão Pulmonar/imunologia , Lesão Pulmonar/patologia , Masculino , Células-Tronco Mesenquimais/citologia , Camundongos , Camundongos Endogâmicos C57BL
9.
BMC Infect Dis ; 20(1): 392, 2020 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-32493291

RESUMO

BACKGROUND: The first yaws eradication campaign reduced the prevalence of yaws by 95%. In recent years, however, yaws has reemerged and is currently subject to a second, ongoing eradication campaign. Yet, the epidemiological status of Tanzania and 75 other countries with a known history of human yaws is currently unknown. Contrary to the situation in humans in Tanzania, recent infection of nonhuman primates (NHPs) with the yaws bacterium Treponema pallidum subsp. pertenue (TPE) have been reported. In this study, we consider a One Health approach to investigate yaws and describe skin ulcers and corresponding T. pallidum serology results among children living in the Tarangire-Manyara ecosystem, an area with increasing wildlife-human interaction in northern Tanzania. METHODS: To investigate human yaws in Tanzania, we conducted a cross-sectional study to screen and interview skin-ulcerated children aged 6 to 15 years, who live in close proximity to two national parks with high numbers of naturally TPE-infected monkeys. Serum samples from children with skin ulcers were tested for antibodies against the bacterium using a treponemal (Treponema pallidum Particle Agglutination assay) and a non-treponemal (Rapid Plasma Reagin) test. RESULTS: A total of 186 children aged between 6 and 15 years (boys: 10.7 ± 2.1 (mean ± SD), N = 132; girls: 10.9 ± 2.0 (mean ± SD), N = 54) were enrolled. Seven children were sampled at health care facilities and 179 at primary schools. 38 children (20.4%) reported active participation in bushmeat hunting and consumption and 26 (13.9%) reported at least one physical contact with a NHP. None of the lesions seen were pathognomonic for yaws. Two children tested positive for treponemal antibodies (1.2%) in the treponemal test, but remained negative in the non-treponemal test. CONCLUSIONS: We found no serological evidence of yaws among children in the Tarangire-Manyara ecosystem. Nevertheless, the close genetic relationship of human and NHPs infecting TPE strains should lead to contact prevention with infected NHPs. Further research investigations are warranted to study the causes and possible prevention measures of spontaneous chronic ulcers among children in rural Tanzania and to certify that the country is free from human yaws.


Assuntos
Anticorpos Antibacterianos/sangue , Úlcera Cutânea/patologia , Treponema pallidum/imunologia , Bouba/patologia , Adolescente , Animais , Criança , Estudos Transversais , Ecossistema , Feminino , Haplorrinos , Humanos , Masculino , Prevalência , Doenças dos Primatas/microbiologia , Doenças dos Primatas/patologia , Úlcera Cutânea/sangue , Úlcera Cutânea/microbiologia , Inquéritos e Questionários , Tanzânia/epidemiologia , Treponema pallidum/isolamento & purificação , Bouba/epidemiologia , Bouba/microbiologia
10.
PLoS One ; 15(5): e0230860, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32413033

RESUMO

Since 2000, human malaria cases in Malaysia were rapidly reduced with the use of insecticides in Indoor Residual Spray (IRS) and Long-Lasting Insecticide Net (LLIN). Unfortunately, monkey malaria in humans has shown an increase especially in Sabah and Sarawak. The insecticide currently used in IRS is deltamethrin K-Othrine® WG 250 wettable granule, targeting mosquitoes that rest and feed indoor. In Sabah, the primary vector for knowlesi malaria is An. balabacensis a species known to bite outdoor. This study evaluates an alternative method, the Outdoor Residual Spray (ORS) using a novel formulation of deltamethrin K-Othrine® (PolyZone) to examine it suitability to control knowlesi malaria vector in Sabah, compared to the current method. The study was performed at seven villages in Sabah having similar type of houses (wood, bamboo and concrete). Houses were sprayed with deltamethrin K-Othrine® (PolyZone) at two different dosages, 25 mg/m2 and 30 mg/m2 and deltamethrin K-Othrine® WG 250 wettable granule at 25 mg/m2, sprayed indoor and outdoor. Residual activity on different walls was assessed using standard cone bioassay techniques. For larval surveillances, potential breeding sites were surveyed. Larvae were collected and identified, pre and post spraying. Adult survey was done using Human Landing Catch (HLC) performed outdoor and indoor. Detection of malaria parasite in adults was conducted via microscopy and molecular methods. Deltamethrin K-Othrine® (PolyZone) showed higher efficacy when sprayed outdoor. The efficacy was found varied when sprayed on different types of wall surfaces. Deltamethrin K-Othrine® (PolyZone) at 25 mg/m2 was the most effective with regards to ability to high mortality and effective knock down (KD). The vector population was reduced significantly post-spraying and reduction in breeding sites as well. The number of simian malaria infected vector, human and simian malaria transmission were also greatly reduced.


Assuntos
Anopheles/efeitos dos fármacos , Inseticidas/toxicidade , Malária/prevenção & controle , Doenças Parasitárias em Animais/prevenção & controle , Aerossóis , Animais , Anopheles/parasitologia , Haplorrinos , Inseticidas/química , Malária/transmissão , Malásia , Nitrilos/química , Doenças Parasitárias em Animais/transmissão , Plasmodium knowlesi/patogenicidade , Piretrinas/química
11.
Eur J Vasc Endovasc Surg ; 60(2): 243-252, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32359973

RESUMO

OBJECTIVE: To review the existing literature on large animal models of central venous thrombosis (CVT) and to evaluate its relevance in regard to the development and testing of dedicated therapeutics applicable to humans. METHODS: A systematic literature search was conducted in PubMed and Embase. Articles describing an in vivo experimental protocol of CVT in large animals, involving the iliac vein and/or the vena cava and/or the brachiocephalic vein, were included. The primary aim of the study, animal characteristics, experimental protocol, and thrombus evaluation were recorded. RESULTS: Thirty-eight papers describing more than 30 different protocols were included. Animals used were pigs (53%), dogs (21%), monkeys (24%), and cattle (3%). The median number of animals per study was 12. Animal sex, strain, and weight were missing in 18 studies (47%), seven studies (18%), and eight studies (21%), respectively. CVT was always induced by venous stasis: solely (55%), or in addition to hypercoagulability (37%) or endothelial damage (10%). The size of the vessel used for thrombus creation was measured in four studies (10%). Unexpected animal death occurred in nine studies (24%), ranging from 3% to 37% of the animals. Twenty-two studies (58%) in the acute phase and 31 studies in the chronic phase (82%) evaluated the presence or absence of the thrombus created, and its occlusive characteristic was reported, respectively, in five and 17 studies. Histological examination was performed in 24 studies (63%) with comparison to human thrombus in one study. CONCLUSION: This review showed advantages and weaknesses of the existing large animal models of CVT. Future models should insist on more rigour and consistency in reporting animal characteristics, as well as evaluating and comparing the thrombus created to human thrombus.


Assuntos
Veias Braquiocefálicas , Veia Ilíaca , Veias Cavas , Trombose Venosa , Animais , Coagulação Sanguínea , Veias Braquiocefálicas/patologia , Modelos Animais de Doenças , Cães , Haplorrinos , Humanos , Veia Ilíaca/patologia , Especificidade da Espécie , Sus scrofa , Veias Cavas/patologia , Trombose Venosa/sangue , Trombose Venosa/etiologia , Trombose Venosa/patologia , Trombose Venosa/terapia
13.
Rinsho Shinkeigaku ; 60(4): 253-259, 2020 Apr 24.
Artigo em Japonês | MEDLINE | ID: mdl-32238749

RESUMO

We have developed a partial peptide of RANKL (receptor activator of NF-κB ligand) that suppresses TLR (toll-like receptor)-related inflammation via RANKL/RANK (receptor activator of nuclear factor-κB) signals in the acute phase of ischemic stroke. This peptide has been found to be a therapeutic agent for ischemic stroke that can be used in combination with tPA in a mouse model. Based on the findings, we are working on translational research to aim for clinical application of this peptide through collaboration with pharmacy companies. However, the problem is that the need for development of medication in the acute stage of ischemic stroke is currently low in pharmaceutical companies due to the failure of many investigational drugs in the past. To overcome the problem, we are examining the effects of this peptide in other diseases included in the company's priority areas and explaining the environmental changes in the clinical trials due to the development of endovascular treatment in the acute stage of ischemic stroke.


Assuntos
Desenvolvimento de Medicamentos , Acidente Vascular Cerebral/tratamento farmacológico , Acidente Vascular Cerebral/etiologia , Pesquisa Médica Translacional , Animais , Haplorrinos , Humanos , Terapia de Alvo Molecular , Receptor Ativador de Fator Nuclear kappa-B , Receptores Toll-Like
14.
J Neurosci ; 40(22): 4348-4362, 2020 05 27.
Artigo em Inglês | MEDLINE | ID: mdl-32327531

RESUMO

The forelimb representation in motor cortex (M1) is an important model system in contemporary neuroscience. Efforts to understand the organization of the M1 forelimb representation in monkeys have focused on inputs and outputs. In contrast, intrinsic M1 connections remain mostly unexplored, which is surprising given that intra-areal connections universally outnumber extrinsic connections. To address this knowledge gap, we first mapped the M1 forelimb representation with intracortical microstimulation (ICMS) in male squirrel monkeys. Next, we determined the connectivity of individual M1 sites with ICMS + intrinsic signal optical imaging (ISOI). Every stimulation site activated a distinctive pattern of patches (∼0.25 to 1.0 mm radius) that we quantified in relation to the motor map. Arm sites activated patches that were mostly in arm zones. Hand sites followed the same principle, but to a lesser extent. The results collectively indicate that preferential connectivity between functionally matched patches is a prominent organizational principle in M1. Connectivity patterns for a given site were conserved across a range of current amplitudes, train durations, pulse frequencies, and microelectrode depths. In addition, we found close correspondence in somatosensory cortex between connectivity that we revealed with ICMS+ISOI and connections known from tracers. ICMS+ISOI is therefore an effective tool for mapping cortical connectivity and is particularly advantageous for sampling large numbers of sites. This feature was instrumental in revealing the spatial specificity of intrinsic M1 connections, which appear to be woven into the somatotopic organization of the forelimb representation. Such a framework invokes the modular organization well-established for sensory cortical areas.SIGNIFICANCE STATEMENT Intrinsic connections are fundamental to the operations of any cortical area. Surprisingly little is known about the organization of intrinsic connections in motor cortex (M1). We addressed this knowledge gap using intracortical microstimulation (ICMS) concurrently with intrinsic signal optical imaging (ISOI). Quantifying the activation patterns from dozens of M1 sites allowed us to uncover a fundamental principle of M1 organization: M1 patches are preferentially connected with functionally matched patches. Relationship between intrinsic connections and neurophysiological map is well-established for sensory cortical areas, but our study is the first to extend this framework to M1. Microstimulation+imaging opened a unique possibility for investigating the connectivity of dozens of tightly spaced M1 sites, which was the linchpin for uncovering organizational principles.


Assuntos
Conectoma , Córtex Motor/fisiologia , Animais , Braço/inervação , Braço/fisiologia , Haplorrinos , Masculino , Córtex Motor/citologia , Neurônios/fisiologia , Imagem Óptica
15.
Cell Rep ; 30(13): 4319-4320, 2020 03 31.
Artigo em Inglês | MEDLINE | ID: mdl-32234469

RESUMO

Hayashi et al. (2020) provide evidence that Japanese macaques show theory of mind abilities in an anticipatory-looking variant of the canonical false belief task. This study paves the way to investigate the neuronal basis of social cognition in non-human primates.


Assuntos
Teoria da Mente , Animais , Haplorrinos , Macaca , Córtex Pré-Frontal , Comportamento Social
17.
Science ; 368(6487): 136-137, 2020 04 10.
Artigo em Inglês | MEDLINE | ID: mdl-32273458
18.
Clin Sci (Lond) ; 134(5): 543-545, 2020 03 13.
Artigo em Inglês | MEDLINE | ID: covidwho-12894

RESUMO

A new coronavirus, referred to as SARS-CoV-2, is responsible for the recent outbreak of severe respiratory disease. This outbreak first detected in Wuhan, China in December 2019, has spread to other regions of China and to 25 other countries as of January, 2020. It has been known since the 2003 SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2). The S1 domain of the spike protein of SARS-CoV attaches the virus to its cellular receptor ACE2 on the host cells. We thought that it is timely to explain the connection between the SARS-CoV, SARS-CoV-2, ACE2 and the rationale for soluble ACE2 as a potential therapy.


Assuntos
Betacoronavirus/patogenicidade , Infecções por Coronavirus/tratamento farmacológico , Peptidil Dipeptidase A , Pneumonia Viral/tratamento farmacológico , Vírus da SARS/patogenicidade , Ligação Viral , Animais , Linhagem Celular , Haplorrinos , Humanos , Peptidil Dipeptidase A/fisiologia , Proteínas Recombinantes/uso terapêutico , Solubilidade , Replicação Viral
19.
Clin Sci (Lond) ; 134(5): 543-545, 2020 03 13.
Artigo em Inglês | MEDLINE | ID: covidwho-8347

RESUMO

A new coronavirus, referred to as SARS-CoV-2, is responsible for the recent outbreak of severe respiratory disease. This outbreak first detected in Wuhan, China in December 2019, has spread to other regions of China and to 25 other countries as of January, 2020. It has been known since the 2003 SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2). The S1 domain of the spike protein of SARS-CoV attaches the virus to its cellular receptor ACE2 on the host cells. We thought that it is timely to explain the connection between the SARS-CoV, SARS-CoV-2, ACE2 and the rationale for soluble ACE2 as a potential therapy.


Assuntos
Betacoronavirus/patogenicidade , Infecções por Coronavirus/tratamento farmacológico , Peptidil Dipeptidase A , Pneumonia Viral/tratamento farmacológico , Vírus da SARS/patogenicidade , Ligação Viral , Animais , Linhagem Celular , Haplorrinos , Humanos , Peptidil Dipeptidase A/fisiologia , Proteínas Recombinantes/uso terapêutico , Solubilidade , Replicação Viral
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