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1.
Kyobu Geka ; 73(11): 947-949, 2020 Oct.
Artigo em Japonês | MEDLINE | ID: mdl-33130721

RESUMO

A 76-year-old woman was admitted to our hospital complaining of dyspnea on effort. Echocardiography showed severe mitral regurgitation. Her medical history indicated that she was allergic to metal, and skin patch tests were positive for nickel, cobalt, platinum, manganese, iridium, chromium, and zinc. Valvuloplasty involved triangular resection of P2 and mitral valve annuloplasty with a metal-free, 29 mm Tailor Flexible Ring. The sternum was closed using polyester non-absorbable sutures instead of surgical steel wire. Her postoperative course was uneventful and she was discharged on postoperative day 21. Nine months later, she is well and free of allergic symptoms.


Assuntos
Hipersensibilidade , Anuloplastia da Valva Mitral , Insuficiência da Valva Mitral , Idoso , Ecocardiografia , Feminino , Humanos , Hipersensibilidade/etiologia , Valva Mitral/diagnóstico por imagem , Valva Mitral/cirurgia , Insuficiência da Valva Mitral/diagnóstico por imagem , Insuficiência da Valva Mitral/etiologia , Insuficiência da Valva Mitral/cirurgia
2.
Nihon Yakurigaku Zasshi ; 155(6): 360-363, 2020.
Artigo em Japonês | MEDLINE | ID: mdl-33132250

RESUMO

Neuropeptide Y (NPY) is a neurotransmitter that is widely expressed in the brain and peripheral nervous system. Various immune cells express the receptor for NPY, Y1 receptor. NPY modulates these cells via its Y1 receptor, and involvement of NPY in the pathophysiology of bronchial asthma, has been reported. Increased plasma levels of NPY in asthmatic patients have been reported. NPY polymorphisms are associated with an increased risk for asthma in overweight subjects and young adults. We and other researchers have reported that using murine models of allergic airway responses, NPY and Y1 receptor play critical roles for the development of allergic airway inflammation and airway hyperresponsiveness. Therefore, manipulating NPY-Y1 pathway represents a novel therapeutic target to control allergic airway responses, and might be beneficial for treatment of bronchial asthma.


Assuntos
Asma , Hipersensibilidade , Animais , Asma/tratamento farmacológico , Humanos , Inflamação , Camundongos , Neuropeptídeo Y , Receptores de Neuropeptídeo Y/genética
3.
Artigo em Japonês | MEDLINE | ID: mdl-33148926

RESUMO

Immunity, which denotes the protection of multicellular organisms against various bacterial and viral infections, is an essential protective mechanism for living organisms. Allergy is a reaction to a foreign substance existing in the environment that is basically not a component of the self. Additionally, autoimmune diseases are associated with the dysfunction in the recognition of self and non-self, and are pathological conditions caused by immune cells attacking their own tissues and cells. In this paper, we outline the current status of immunity with respect to the environment from the epidemiological perspective with regard to the following: (1) evolution and immunity, (2) allergy, (3) autoantibodies, (4) autoimmune diseases, (5) relationships of immunity with the environment, allergy, autoantibodies, and autoimmune diseases, and (6) celiac disease.


Assuntos
Doenças Autoimunes/imunologia , Autoimunidade , Hipersensibilidade/imunologia , Adolescente , Adulto , Idoso , Autoanticorpos , Doenças Autoimunes/epidemiologia , Evolução Biológica , Doença Celíaca/imunologia , Criança , Pré-Escolar , Meio Ambiente , Feminino , Humanos , Hipersensibilidade/epidemiologia , Lactente , Masculino , Pessoa de Meia-Idade , Adulto Jovem
4.
Stud Health Technol Inform ; 273: 170-175, 2020 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-33087608

RESUMO

The use of different data formats complicates the standardization and exchange of valuable medical data. Moreover, a big part of medical data is stored as unstructured medical records that are complicated to process. In this work we solve the task of unstructured allergy anamnesis categorization according to categories provided by FHIR. We applied two stage classification model with manually labeled records. On the first stage the model filters records with information about allergies and on the second stage it categorizes each record. The model showed high performance. The development of this approach will ensure secondary use of data and interoperability.


Assuntos
Registros Eletrônicos de Saúde , Hipersensibilidade , Humanos , Registros
5.
Ann Parasitol ; (3): 415-418, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33128868

RESUMO

Cutaneous leishmaniosis (CL) transmitted by the bite of infected female phlebotomine sand flies endemic in many parts of rural and urban areas of Kashan, central Iran. Rare systemic allergic reactions, including anaphylaxis can occur in response to the bites of mosquitoes. In 2019, the patient was a 20-yr-old woman referring to the Health Care Centre in Kashan, central Iran, and complaint of symptoms allergic. After receiving anti-allergic drug therapy a month, skin lesions appeared on her forehead, forearm, and right arm. The disease was diagnosed with positive CL by direct smear. Her lesion treated with systemic meglumine antimonate (Glucantime®) (1.5 g/5ml/week) for seven-week. In conclusion, CL, as a public health problem, especially for travellers and patients with allergies to insect bites, is the most common in endemic areas. It guides us to consider the control programs of this disease, and much attention should be given to improve the environmental conditions for vector-borne control and public health education for personal protection.


Assuntos
Hipersensibilidade , Leishmaniose Cutânea , Psychodidae , Animais , Feminino , Humanos , Irã (Geográfico)/epidemiologia , Leishmaniose Cutânea/tratamento farmacológico , Leishmaniose Cutânea/epidemiologia , Mosquitos Vetores
7.
Artigo em Alemão | MEDLINE | ID: mdl-33095280

RESUMO

Currently, extract-based therapeutic allergens from natural allergen sources (e.g., house dust mites, tree and grass pollen) are used for allergen-specific immunotherapy (AIT), the only causative therapy that can exhibit positive disease-modifying effects by tolerance induction and prevention of disease progression. Due to variations in the natural composition of the starting materials and different manufacturing processes, there are variations in protein content, allergen composition, and allergenic activity of similar products, which poses specific challenges for their standardization. The identification of the nucleotide sequences of allergenic proteins led to the development of molecular AIT approaches. This allows for the application of exclusively relevant structures as chemically synthesized peptides, recombinant single allergens, or molecules with hypoallergenic properties that potentially allow for an up-dosing with higher allergen-doses without allergic side effects leading more quickly to effective cumulative doses. Further modifications of AIT preparations to improve allergenic and immunogenic properties may be achieved, e.g., by including the use of virus-like particles (VLPs). To date, the herein described therapeutic approaches have been tested in clinical trials only. This article provides an overview of published molecular approaches for allergy treatment used in clinical AIT studies. Their added value and challenges compared to established therapeutic allergens are discussed. The aim of these approaches is to develop highly effective and well-tolerated AIT preparations with improved patient acceptance and adherence.


Assuntos
Alérgenos , Hipersensibilidade , Dessensibilização Imunológica , Alemanha , Humanos , Hipersensibilidade/terapia , Imunoterapia , Peptídeos
8.
Front Immunol ; 11: 576255, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33117377

RESUMO

In the last decade single domain antibodies (nanobodies, VHH) qualified through their unique characteristics have emerged as accepted and even advantageous alternative to conventional antibodies and have shown great potential as diagnostic and therapeutic tools. Currently nanobodies find their main medical application area in the fields of oncology and neurodegenerative diseases. According to late-breaking information, nanobodies specific for coronavirus spikes have been generated these days to test their suitability as useful therapeutics for future outbreaks. Their superior properties such as chemical stability, high affinity to a broad spectrum of epitopes, low immunogenicity, ease of their generation, selection and production proved nanobodies also to be remarkable to investigate their efficacy for passive treatment of type I allergy, an exaggerated immune reaction to foreign antigens with increasing global prevalence.


Assuntos
Anticorpos Bloqueadores/uso terapêutico , Hipersensibilidade/terapia , Imunoterapia/métodos , Anticorpos de Domínio Único/uso terapêutico , Anticorpos Bloqueadores/imunologia , Antígenos/imunologia , Epitopos/imunologia , Humanos , Imunoglobulina E/imunologia , Anticorpos de Domínio Único/imunologia
9.
Rev Prat ; 70(3): 305-309, 2020 Mar.
Artigo em Francês | MEDLINE | ID: mdl-32877066

RESUMO

Complications related to tattoo practice. Tattooing can result in a wide variety of complications, whose prevalence and incidence remain still unclear. Hypersensitivity reactions (or allergies) to tattoo pigments are currently the most common complication on a tattoo, however are not predictable. Infections are nowadays directly related to the lack of asepsis and hygiene during the tattooing procedure or during the healing phase. Patients with a known cutaneous disease should be warned of a potential risk of localization of their disease to the tattoo. Patients with chronic conditions and/or impaired immunity should discuss with their physician about the possibility and when to have a tattoo. Laser removal is the gold standard for tattoo removal and include Q-switched, picoseconds and CO2 lasers. However, a complete disappearance of the tattoo is not always possible.


Assuntos
Hipersensibilidade , Dermatopatias , Tatuagem , Humanos , Higiene , Tatuagem/efeitos adversos
10.
Clin Imaging ; 67: 214-218, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32871425

RESUMO

This article reports 2 adult patients who had developed an acute allergic reaction to food ingredients or medications, respectively. Both patients presented with concurrent urticaria of the skin and colon. The latter finding appeared as numerous raised plaques of the colonic mucosa on radiographic and computed tomography (CT) of the abdomen. The urticarial lesions affecting the skin and large bowel resembled each other and resolved after treatment with antihistamines. Pertinent clinical data and previously published cases of this unusual entity are briefly reviewed.


Assuntos
Colo/diagnóstico por imagem , Hipersensibilidade , Urticária/diagnóstico por imagem , Adulto , Feminino , Humanos , Masculino , Pele/patologia , Urticária/tratamento farmacológico , Urticária/etiologia
11.
Rev Alerg Mex ; 67(2): 199-201, 2020.
Artigo em Espanhol | MEDLINE | ID: mdl-32892535
12.
Rev Prat ; 70(2): 195-199, 2020 Feb.
Artigo em Francês | MEDLINE | ID: mdl-32877140

RESUMO

Asthma and allergy: what about the differences between men and women? Allergic asthma is a chronic pulmonary disease characterized by bronchial hyper responsiveness, hyper production of mucus and remodeling of the airways. Asthma, which often begins before the age of 5, is the most common chronic disease in children and affects approximately 10% of the population in affluent societies. As it is the case for many allergic diseases, asthma affects men and women differently. In childhood, pathology is more common in boys, but this trend reverses at puberty, suggesting a regulation by sex hormones. In this review, we summarize the current knowledge on how sex hormones impact allergic inflammation and particularly describe the protective actions of androgens on the development and function of key immune cell subsets involved in allergic responses.


Assuntos
Asma , Hipersensibilidade , Criança , Feminino , Humanos , Inflamação , Masculino
13.
Yonsei Med J ; 61(9): 797-804, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32882764

RESUMO

PURPOSE: Climate and lifestyle changes increase an individual's susceptibility to various allergens and also the incidence of allergic diseases. We aimed to examine the changes in sensitization rate for aeroallergens over a 10-year period in Korean children. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 4493 children who visited the allergy clinic at a tertiary hospital in Korea for allergic rhinitis or asthma from January 2009 to December 2018. The serum specific immunoglobulin E (IgE) levels were measured to confirm the sensitization against Dermatophagoides farinae (D. farinae), Alternaria, weed and tree pollen mixtures, as well as cat and dog dander through ImmunoCAP test. RESULTS: D. farinae was the most common sensitizing aeroallergen (45.9%) during the 10-year span. The sensitization rate for tree pollen mixture (p for trend <0.001), weed pollen mixtures (p for trend <0.001), dog dander (p for trend=0.025), and cat dander (p for trend=0.003) showed ascending trends during the 10-year study period. Furthermore, the sensitization rate for multiple allergens (≥2) in 2018 increased significantly compared to that in 2009 (p for trend=0.013). Compared with children without sensitization to D. farinae, those with sensitization to D. farinae showed higher sensitization rates to other aeroallergens (p for interaction <0.001). CONCLUSION: Children's sensitization rate to cat and dog dander and weed and tree pollen mixtures significantly increased during the 10-year period in Korea. Children with sensitization to D. farinae are likely to be sensitized to other aeroallergens as well.


Assuntos
Alérgenos/imunologia , Asma/imunologia , Hipersensibilidade/diagnóstico , Imunoglobulina E/sangue , Rinite Alérgica/imunologia , Alérgenos/efeitos adversos , Animais , Asma/diagnóstico , Asma/epidemiologia , Gatos , Criança , Dermatophagoides farinae , Cães , Feminino , Humanos , Hipersensibilidade/imunologia , Masculino , Pólen/imunologia , República da Coreia/epidemiologia , Estudos Retrospectivos , Rinite Alérgica/diagnóstico
14.
Harefuah ; 159(9): 697-702, 2020 Sep.
Artigo em Hebraico | MEDLINE | ID: mdl-32955815

RESUMO

INTRODUCTION: Silicone is a foreign material to our body and therefore, has been found to stimulate the immune system. Silicone breast implants (SBIs), made of silicone polymer, have been used for aesthetic and medical purposes since the 1960s, and were found to trigger acute/chronic inflammation, eventually leading to the formation of fibrotic capsules on the surface of the implant. Silicone implants have been found to be associated with the development of severe and sometimes unexplained clinical manifestations such as: chronic fatigue, sleep and memory problems, widespread pain, dry mouth and eye, depression, arthralgia, myalgia, palpitations, tinnitus and hearing loss, skin rash, hair loss, vision problems, hyperhidrosis, allergic reactions, etc. Furthermore, SBIs have been found to be associated with the development of rheumatologic/autoimmune diseases and the development of rare lymphoma. The FDA has expressed concern over the years about the implications of SBIs and requested that the companies involved provide data of any concern regarding the implants. However, the companies continued to sell the implants without reporting data, as agreed. In October 2019, the FDA recommended boxed warnings describing the dangers facing women applying for SBIs such as lymphoma. Importantly, our lab recently found the presence of autoantibodies against the autonomic nervous system in the blood of women with SBIs, which might explain some of the patients' severe symptoms. Owing to the numerous data that had been accumulated (since 1960s) indicating a direct link between silicone, autoimmune diseases and cancer, we believe that the use of SBIs has been a historical medical error.


Assuntos
Implantes de Mama , Erros Médicos , Doenças Autoimunes , Feminino , Humanos , Hipersensibilidade , Silicones
16.
Ann Agric Environ Med ; 27(3): 413-417, 2020 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-32955224

RESUMO

INTRODUCTION: Allergy affects approximately one-third of the world's population, and the rates are growing. In Europe, it has been noticed that the risk of asthma and allergy is lower in the rural as opposed to urban population. There is a tendency for several allergic diseases to be present in the same person at the same time. OBJECTIVE: The aim of the study was to verify the co-occurrence of allergic multimorbidity and food allergy and intolerance in a group of children. MATERIAL AND METHODS: The multicentre cross-sectional study enrolled 1,008 children and adolescence aged 6-18 years (51.2% boys, 48.8% girls). The study comprised a questionnaire (respondents' declarations) and an outpatient examination (diagnostic examination followed by a medical diagnosis). The study was conducted as part of the 2016-2020 National Health Programme. RESULTS: In the study group, allergic rhinitis (AR) was present in 46.4%, bronchial asthma (BA) in 11.2% and atopic dermatitis (AD) in 6%. Allergic multimorbidity (simultaneous presence of 2 or more of the allergic diseases AR, BA and AD) was diagnosed in 9.7%. A single allergic disease (of the 3) was diagnosed in 43.4%. A diagnosis of food allergy and food intolerance was reported respectively at 29.6% and 14.3% participants with doctor-diagnosed allergic multimorbidity. Among those without any of the 3 allergic diseases, the percentage were 14.4% and 9.1%, respectively. CONCLUSIONS: Food allergy or food intolerance was more common in subjects with allergic multimorbidity than in subjects diagnosed with one allergic disease or those free of allergic diseases.


Assuntos
Hipersensibilidade Alimentar/epidemiologia , Intolerância Alimentar/epidemiologia , Multimorbidade , Adolescente , Criança , Estudos Transversais , Feminino , Hipersensibilidade Alimentar/etiologia , Intolerância Alimentar/etiologia , Humanos , Hipersensibilidade/epidemiologia , Hipersensibilidade/etiologia , Masculino , Polônia/epidemiologia , Prevalência
17.
J Oral Facial Pain Headache ; 34: s73-s84, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32975542

RESUMO

AIMS: To quantify the contributions of atopic disorders, sleep disturbance, and other health conditions to five common pain conditions. METHODS: This cross-sectional analysis used data from 655 participants in the OPPERA study. The authors investigated the individual and collective associations of five chronic overlapping pain conditions (COPCs) with medically diagnosed atopic disorders and self-reported sleep disturbance, fatigue, and symptoms of obstructive sleep apnea. Atopic disorders were allergies, allergic rhinitis, atopic dermatitis, allergic asthma, urticaria, allergic conjunctivitis, and food allergy. Logistic regression models estimated odds ratios as measures of association with temporomandibular disorders, headache, irritable bowel syndrome, low back pain, and fibromyalgia. Measures of sleep and atopy disorders were standardized to z scores to determine the relative strength of their associations with each COPC. Sociodemographic characteristics and body mass index were covariates. Random forest regression analyzed all variables simultaneously, computing importance metrics to determine which variables best differentiated pain cases from controls. RESULTS: Fatigue and sleep disturbance were strongly associated with each COPC and with the total number of COPCs. An increase of one standard deviation in fatigue or sleep disturbance score was associated with approximately two-fold greater odds of having a COPC. In random forest models, atopic disorders contributed more than other health measures to differentiating between cases and controls of headache, whereas other COPCs were best differentiated by measures of fatigue or sleep. CONCLUSION: Atopic disorders, previously recognized as predictors of poor sleep, are associated with COPCs after accounting for sleep problems.


Assuntos
Asma , Dor Crônica , Hipersensibilidade/epidemiologia , Transtornos do Sono-Vigília/epidemiologia , Estudos Transversais , Humanos
18.
S Afr Med J ; 110(7): 686-690, 2020 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-32880348

RESUMO

BACKGROUND: Allergy is a common health problem in South Africa (SA), and a rational approach to allergy testing is essential to ensure cost-effective as well as optimal patient diagnosis and management. OBJECTIVES: To review allergy testing data with respect to current national testing recommendations, and to explore the regional variations in sensitisation. METHODS: Retrospective data review on allergy testing from a private pathology provider in SA over a 2-year period. Data on skin-prick testing (SPT) and allergen-specific IgE testing originating from all the provinces of SA were collected and analysed with regards to allergen positivity rate and regional sensitisation patterns. RESULTS: Among the patients (N=45 0320) tested for a suspected inhalant allergy, 46% tested positive. Only 45% of these received additional testing for the nine recommended inhalant allergens included in the current national testing protocol. Among the patients (N=6 775) who received SPT for a suspected inhalant allergy, 59% yielded one or more positive results. The most frequent sensitising allergens were house dust mite (Dermatophagoides pteronyssinus) and grass pollen. The house dust mite, Blomia tropicalis, was a significant sensitiser in coastal regions. SPT identified two other important regional allergens which are not included in the current recommendations for inhalant allergen-specific IgE testing. CONCLUSIONS: The current diagnostic recommendations include allergens that demonstrate significant sensitisation in all regions of SA. Two additional allergens that show significant regional sensitisation in the South African population were identified. These findings may aid the recommendations for the most appropriate and cost-effective approach to allergy testing of symptomatic patients in SA.


Assuntos
Hipersensibilidade/epidemiologia , Alérgenos/imunologia , Animais , Humanos , Imunoglobulina E/sangue , Pólen/imunologia , Pyroglyphidae/imunologia , Estudos Retrospectivos , Testes Cutâneos , África do Sul/epidemiologia
19.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi ; 36(8): 687-692, 2020 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-32958124

RESUMO

Objective To establish a mouse neutrophil-dominated asthma model using house dust mite (HDM). Methods With a random number table, a total of 16 specific pathogen-free (SPF) BALB/c mice were divided into control group and model group. The model group was sensitized and stimulated by HDM nasal drip, and the control group mice were given the same amount of saline. In 24 hours after the last stimulation, the enhanced pause (Penh) was measured by the BUXCO noninvasive lung function detector to determine the airway resistance; the bronchoalveolar lavage fluid (BALF) was collected to count cells and classify inflammatory cells. The infiltration degree of inflammatory cells in the lung tissue was observed by HE staining. The expression of IL-6, IL-17F and IL-1ß mRNA was detected by real-time quantitative PCR, and the levels of IL-4, IL-6, IL-17F and tumor necrosis factor α (TNF-α) in BALF were detected by cytometric bead array (CBA). Results Compared with the control group, the value of Penh in the model group was significantly higher; the tracheal and paravascular inflammation significantly aggravated; the levels of IL-6, IL-17F, IL-1ß mRNA, the cell count and neutrophil count in BALF, and the levels of neutrophil cytokines IL-6, IL-17F and TNF-α in the BALF increased significantly. Conclusion The mouse neutrophil-dominated house dust mite allergic asthma model has been successfully established.


Assuntos
Asma , Modelos Animais de Doenças , Hipersensibilidade , Neutrófilos , Pyroglyphidae , Animais , Líquido da Lavagem Broncoalveolar/citologia , Líquido da Lavagem Broncoalveolar/imunologia , Citocinas/genética , Regulação da Expressão Gênica/imunologia , Hipersensibilidade/imunologia , Pulmão/imunologia , Camundongos , Camundongos Endogâmicos BALB C , Neutrófilos/imunologia , Pyroglyphidae/imunologia , Distribuição Aleatória
20.
PLoS One ; 15(9): e0238740, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32898145

RESUMO

Sensitization to Hymenoptera venom in patients without a history of systemic allergic reactions to Hymenoptera stings is frequently found and can be due to the presence of specific IgE to cross-reactive carbohydrate determinants (CCD). This study investigates 105 pollen allergic subjects for the presence of specific IgE to honeybee or wasp venom, pollen, the MUXF3 carbohydrate epitope from bromelain and recombinant Hymenoptera venom components. In addition, in a subgroup of patients (n = 10) a basophil activation test (BAT) using bee and wasp venom was performed. Specific IgE to Hymenoptera venom was detected in 45.7% of the pollen allergic subjects and in 26.7% of the non-atopic controls, both without a history of systemic allergic reactions to Hymenoptera stings. The high sensitization rate in atopic patients could partially be explained by cross-sensitization between pollen and Hymenoptera venom due to specific IgE to CCDs. In our study population, only 20% showed a sensitization to CCDs. Primary sensitization due to sting exposure, high total IgE values or unspecific binding and detection of low affinity antibodies in the test procedure could be reasons. Thus, determination of specific IgE to Hymenoptera venom in patients without a history of systemic allergic reactions as screening test is not recommended.


Assuntos
Venenos de Abelha/imunologia , Carboidratos/imunologia , Reações Cruzadas , Himenópteros/imunologia , Hipersensibilidade/imunologia , Venenos de Vespas/imunologia , Adolescente , Adulto , Idoso , Alérgenos/imunologia , Animais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
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