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1.
Int Arch Allergy Immunol ; 181(1): 31-42, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31694023

RESUMO

Irritable bowel syndrome (IBS) is a functional gastrointestinal disease and the most common cause of prolonged abdominal pain and bowel disturbances in the developed world. While initially thought to be functional or psychosomatic in nature, IBS is now recognized as a heterogeneous group of conditions. A subset of IBS patients and patients with allergic diseases share some characteristic inflammatory features. In fact, atopic children show an increased likelihood of developing IBS as adults. Given these findings, a subset of IBS may be suffering from allergy-related gut diseases. In this review, we present the allergy-related comorbidities of IBS, including genetic, environmental, and immunologic factors. We discuss studies demonstrating an increased sensitization of IBS patients to aeroallergens compared to food allergens. We then postulate potential pathophysiological mechanisms underlying both IBS and aeroallergens in the gut, followed by potential implications in the screening and treatment of allergies in IBS patients.


Assuntos
Gastroenteropatias/imunologia , Hipersensibilidade/imunologia , Inflamação/imunologia , Síndrome do Intestino Irritável/imunologia , Poluição do Ar , Alérgenos/imunologia , Animais , Criança , Comorbidade , Gastroenteropatias/epidemiologia , Humanos , Hipersensibilidade/epidemiologia , Síndrome do Intestino Irritável/epidemiologia , Risco
3.
Med Clin North Am ; 104(1): 129-143, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31757231

RESUMO

Stinging insect allergy is uncommon but can be life threatening. Diagnosis requires clinical history and confirmative skin or blood testing by an allergist. Baseline serum tryptase level can be used to stratify risk. Treatment is supportive for all reactions except for anaphylaxis, which is treated with intramuscular epinephrine, recumbent posture, and adjunct measures such as IV fluids, and oxygen. Venom immunotherapy is most effective for long-term management in patients with a history of anaphylaxis. Venom immunotherapy rapidly reduces the risk of sting anaphylaxis by up to 98% and maintenance treatment can be stopped after 5 years in most cases.


Assuntos
Anafilaxia/tratamento farmacológico , Epinefrina/uso terapêutico , Hipersensibilidade/tratamento farmacológico , Mordeduras e Picadas de Insetos/complicações , Anafilaxia/etiologia , Animais , Humanos , Hipersensibilidade/etiologia , Imunoterapia/métodos , Peçonhas/uso terapêutico
4.
Arerugi ; 68(10): 1196-1199, 2019.
Artigo em Japonês | MEDLINE | ID: mdl-31827027
6.
Urologiia ; (5): 64-71, 2019 Dec.
Artigo em Russo | MEDLINE | ID: mdl-31808635

RESUMO

AIM: A comparative evaluation of the efficacy and safety of Canephron N and Cystone as monotherapy in women with acute uncomplicated cystitis and antibiotic allergy or intolerance was performed. MATERIALS AND METHODS: A prospective, randomized, controlled study of drug Canephron N as monotherapy for acute uncomplicated cystitis in 51 women with a history of antibiotic allergy or intolerance was carried out in 3 urological centers in Perm from 2016 to 2019. In the main group, patients received Canephron N for 30 days, while in comparison group, Cystone was prescribed. The Acute Cystitis Symptom Score (ACSS), microscopic study of urine sediment, urine culture and other methods were used. Results were evaluated 3, 6, 30 days and 1 year after the start of treatment. RESULTS: In the main group, monotherapy with Canephron N for 30 days resulted in a decrease in the total ACSS score from the baseline 12.9 to 0.3 points, while in Cyston group, changes of ACSS score were less pronounced, from baseline 12.8 to 1.4 points (p<0.01). Clinical cure rate in the main and comparison group was 88.5% and 68%, respectively. In another 3.8% and 1% of patients in the main and comparison group, an improvement was seen. The number of patients with leukocyturia in the Canephron N group decreased to 11.5% compared to 28% in Cyston group (p>0.05). Bacteriuria rate in the main group was 7.7%, which was less than in the comparison group (20%, p>0.05). Number of sick days in the main group was 4.9+/-0.4, compared to 7.4+/-0.6 days in Cyston group. In the Canephron N group, 1-year recurrence rate was only 7.7%, while in the Cyston group the recurrence was seen in 16% of patients. CONCLUSION: According to the results, Canephron N is an effective and safe drug as monotherapy for acute uncomplicated cystitis, and can be considered as drug of choice for the treatment of women with antibiotic allergy or intolerance.


Assuntos
Bacteriúria/tratamento farmacológico , Cistite/tratamento farmacológico , Extratos Vegetais/uso terapêutico , Doença Aguda , Adulto , Antibacterianos/administração & dosagem , Antibacterianos/efeitos adversos , Bacteriúria/microbiologia , Cistite/microbiologia , Feminino , Humanos , Hipersensibilidade , Estudos Prospectivos , Resultado do Tratamento
7.
Diagn. tratamento ; 24(4): [153-157], out - dez. 2019. fig, tab
Artigo em Português | LILACS | ID: biblio-1049386

RESUMO

Contexto e objetivos: Aroeira é o nome popular de árvores da família Anacardiaceae, que inclui plantas sensibilizantes como a poison ivy norte-americana (Toxicodendron radicans), o cajueiro (Anacardium occidentale) e a mangueira (Mangifera indica). Este estudo procura caracterizar o conhecimento sobre as aroeiras e a frequência de manifestações clínicas em camponeses. Desenho e local: Foi realizado estudo retrospectivo e prospectivo com pacientes e acompanhantes residentes em ampla área rural de cerrado no Centro-Oeste paulista. Métodos: A frequência e a relação causal entre a exposição a aroeiras, comuns na região, e a dermatite eczematosa típica foi pesquisada. Para a avaliação, foi utilizado um questionário específico. Resultados: Todos os 39 entrevistados conheciam aroeiras (100%) e 17 deles (43,58%) relataram ter se aproximado ou descansado sob essas árvores. Mais da metade deles (56,41% ou 22 indivíduos) relataram dermatites que relacionaram às arvores. Os demais entrevistados não desenvolveram reações, mas conheciam pessoas que o fizeram (43,59%). Três pacientes, ou 7,69% da amostra, apresentavam lesões de padrão eczematoso, creditando-as ao contato com aroeiras-bravas (Lithraea molleoides). Discussão: Devido à alta frequência com que essas árvores são encontradas no campo (cerrado brasileiro) e aos dados obtidos, percebemos também uma alta frequência de sensibilização nas áreas rurais. Conclusões: É imperativo que as campanhas de orientação e alerta sejam desenvolvidas para aumentar a conscientização sobre riscos potenciais, de modo que o contato com essas árvores seja evitado, evitando condições alérgicas que podem ser tão extensas quanto graves.


Assuntos
Saúde Pública , Estudos Retrospectivos , Anacardiaceae , Dermatite de Contato , Toxicidade , Hipersensibilidade
8.
Odontoestomatol ; 21(34): 33-43, Jul-Dic. 2019.
Artigo em Espanhol | LILACS, InstitutionalDB | ID: biblio-1024977

RESUMO

Los vidrios bioactivos (vb) son materiales cerámicos con una composición química tal que poseen la propiedad de inducir y conducir la mineralización de los tejidos. La obtención de estos vidrios por medio del método sol-gel y la posibilidad de obtener tamaño nanométrico de partícula, han ampliado y potenciado las indicaciones de estos materiales. Las propiedades antibacterianas de los vb son una característica sobresaliente; es debida a la liberación de iones que alcaliniza el medio, actuando sobre las colonias bacterianas. Las aplicaciones médicas y odontológicas de estos materiales son muy amplias, destacándose la regeneración ósea, la remineralización de los tejidos duros dentarios y el tratamiento de la hipersensibilidad. Sin embargo, por tratarse de materiales con estructura química amorfa, sus propiedades mecánicas no son buenas, siendo esta característica su principal limitación para la aplicación clínica en el área de la odontología restauradora. En este sentido las investigaciones científicas se han enfocado en determinar la posibilidad de incorporar vb a diversos materiales dentales como forma de combinar su bioactividad con propiedades mecánicas apropiadas. Hasta el momento no se ha logrado determinar la proporción y la metodología para incorporar vb en los materiales dentales sin alterar su comportamiento clínico, por lo que son necesarias más investigaciones.


Bioactive glasses (bg) are ceramic materials whose chemical composition allows them to induce and conduct tissue mineralization. As these glasses can be obtained with the sol-gel method and in nanometric particle sizes, their indication has been extended and enhanced. The antibacterial properties of bg are outstanding: they are possible given the release of ions, which alkalinizes the medium, acting on the bacterial colonies. The medical and dental applications of these materials are wide, with an emphasis on bone regeneration, remineralization of hard dental tissues and treatment of hypersensitivity. However, as they are materials with an amorphous chemical structure, their mechanical properties are not good, this being their main limitation for clinical application in restorative dentistry. In this sense, scientificresearch has focused on determining the possibility of including bg in various dental materials as a way to combine bioactivity with appropriate mechanical properties. So far, it has not been possible to determine the proportion and methodology necessary to include bg in dental materials without altering their clinical behavior, which is why further research isnecessary


Os vidros bioativos (vb) são materiais cerâmicos com uma composição química tal que eles possuem a propriedade de induzir e conduzir a mineralização dos tecidos. A obtenção desses vidros por meio do método sol-gel e a possibilidade de obtenção de partículas nanométricas ampliaram e reforçaram as indicações desses materiais. As propriedades antibacterianas dovb são uma característica marcante; é devido à liberação de íons que alcaliniza o meio, atuando nas colônias bacterianas. As aplicações médicas e odontológicas desses materiais são muito amplas, destacando-se a regeneração óssea, a remineralização dos tecidos duros e o tratamento da hipersensibilidade. No entanto, por serem materiais com estrutura química amorfa, suas propriedades mecânicas não são boas, sendo essa a sua principal limitação para aplicação clínica na área de odontologia restauradora. Nesse sentido, a pesquisa científica tem se concentrado em determinar a possibilidade de incorporar vb em vários materiais odontológicos, como forma de combinar sua bioatividade com propriedades mecânicas apropriadas. Até agora, não foi possível determinar a proporção e metodologia para incorporar vb em materiais odontológicos sem alterar seu comportamento clínico, razão pela qual mais pesquisas são necessárias


Assuntos
Humanos , Remineralização Dentária , Hipersensibilidade , Materiais Dentários , Vidro
9.
Medicine (Baltimore) ; 98(52): e18394, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31876711

RESUMO

BACKGROUND: As abundant evidence shows the composition of gut flora in children born by caesarean section is different from that of vaginal delivery children, studies on whether caesarean section would increase the offspring's risk of developing allergic disease attract extensive attention. However, the results of different researches are inconsistent. Therefore we conduct a systematic review and meta-analysis to explore the relationship between caesarean section and childhood allergic disease. METHODS: The protocol followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. Cohort studies for investigating the relationship between caesarean section and the risk of childhood allergic disease will be searched in 4 main databases (PubMed, EMBASE, the Cochrane Library, and the web of science). In addition, a manual search of the references of relevant published studies will also be considered. Four common allergic outcomes will be included: asthma, allergic rhinitis, food allergy, and atopic dermatitis. Studies selection, data extraction, and risk of bias assessment will be conducted by 2 independent reviewers. The primary outcome is the incidence of 4 allergic diseases. RESULTS: The results will provide useful information on whether caesarean section contributes to the increase of allergic disease in children. CONCLUSION: The findings of this study will be published in a peer-reviewed journal. PROSPERO REGISTRATION NUMBER: CRD42019135196.


Assuntos
Cesárea/efeitos adversos , Hipersensibilidade/etiologia , Criança , Humanos , Fatores de Risco
10.
Actas dermo-sifiliogr. (Ed. impr.) ; 110(10): 800-808, dic. 2019. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-185601

RESUMO

Tradicionalmente, la piel sensible se ha considerado como un problema cosmético o como una alteración puramente psicosomática con un fuerte componente subjetivo. Sin embargo, diversos estudios científicos sobre sus procesos fisiopatológicos y su etiopatogenia han demostrado que se trata de una entidad compleja que ya diversos autores consideran un síndrome neurodermatológico. Sus características hacen que su diagnóstico y tratamiento puedan resultar complicados en la práctica clínica habitual, siendo necesarias herramientas sencillas que se puedan usar de rutina, tanto para identificar esta entidad, que puede presentarse acompañada de otra patología, como para su manejo independiente. En este trabajo realizamos una revisión práctica de los avances científicos más recientes el campo de la piel sensible que justifican su consideración individual y ofrecen herramientas para identificarla y tratarla. Proponemos algoritmos de diagnóstico y de tratamiento basados en las evidencias de la literatura y en la opinión de los expertos que firman este artículo


Sensitive skin has traditionally been viewed as a cosmetic problem or as a purely psychosomatic alteration with a major subjective component. Different studies of its pathophysiologic etiology, however, have shown it to be a complex entity that several authors now consider to be a neurodermatological syndrome. Because of this complexity, skin sensitivity can be difficult to diagnose and treat, particularly considering that it may present with another disease. Simple tools applicable to clinical practice are thus necessary to identify and manage this disease as an independent entity. In this study, we perform a practical review of the most recent scientific advances in the area of sensitive skin that justify it being considered an individual entity, and provide tools for its identification and treatment. We propose diagnostic and treatment algorithms based on evidence from the literature and our experience and expertise


Assuntos
Humanos , Hipersensibilidade/epidemiologia , Algoritmos , Dermatite/epidemiologia , Prurido/etiologia , Prurido/diagnóstico , Síndrome , Dermatite/fisiopatologia , Dermatite/classificação , Neuropeptídeos , Substância P , Prurido/imunologia , Higiene
11.
J Agric Food Chem ; 67(47): 13127-13138, 2019 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-31682438

RESUMO

Allergen-specific immunotherapy is the only available curative treatment for IgE-mediated allergen diseases. A safe hypoallergenic allergen derivative with high efficiency is required as a tolerogen to induce immune tolerance to the causitive allergens. In this study, to generate a rice-based oral allergy vaccine for Japanese cedar (JC) pollinosis, the tertiary structures of major JC pollen allergens, Cry j 1 and Cry j 2, were more completely destructed by shuffling than the previous ones without losing immunogenicity and then were specifically expressed in the endosperm of transgenic rice seed. They accumulated at high levels and were deposited in endoplasmic reticulum (ER) and ER-derived protein bodies. The low allergenicity of these deconstructed Cry j 1 and Cry j 2 allergens was evaluated by examining their binding activities to the specific IgE antibody and by the basophil degranulation test.


Assuntos
Antígenos de Plantas/imunologia , Cryptomeria/imunologia , Hipersensibilidade/imunologia , Oryza/genética , Plantas Geneticamente Modificadas/genética , Animais , Antígenos de Plantas/genética , Cryptomeria/genética , Humanos , Hipersensibilidade/terapia , Imunoterapia , Camundongos , Oryza/metabolismo , Plantas Geneticamente Modificadas/metabolismo , Pólen/genética , Pólen/imunologia , Ratos , Sementes/genética , Sementes/imunologia , Vacinas/administração & dosagem , Vacinas/genética , Vacinas/imunologia
15.
Klin Lab Diagn ; 64(11): 677-680, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31747497

RESUMO

Paecilomyces variotii is a commonly occurring species in air and food, and it is also associated with many types of human infections. Tissue forms of the fungus Paecilomyces variotii or their cytoskeletons were revealed in the cytoplasm of erythrocytes in patients with allergy and bronchial asthma in paecilomycosis. Our study was aimed at investigating the role of red blood cells in the mechanisms of the nonspecific protection of the host in conditions of chronic persistent infection of the blood with the fungus of the genus Paecilomyces. We examined a total of eighty-four 16-to-72-year-old patients (39 men and 45 women) presenting with activation of paecilomyces infection in blood. We used laboratory, biochemical, allergic-and-immunological and microbiological methods of study. Fungal cultures were identified phenotypically and by means of phylogenetic analysis.Our findings are suggestive of a new type of the oxygen-dependent mechanism of cytotoxicity of erythrocytes, which is caused by permanent formation of reactive oxygen species as a result of non-enzymatic oxidation of haemoglobin to methaemoglobin. The resulting superoxide anion radical (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (OH-) exhibit a powerful bactericidal action which is, probably, activated when the fungal cells are captured and immersed in the erythrocyte cytoplasm or in a closed cavity formed by RBCs around large fungal cells. In conditions of chronic blood infection with tissue forms of fungi of the genus Paecilomyces oxygen-dependent cytotoxicity of erythrocytes is the main mechanism of readjustment of blood from the infectious agent of Paecilomycosis.


Assuntos
Eritrócitos/microbiologia , Micoses/sangue , Paecilomyces/patogenicidade , Adolescente , Adulto , Idoso , Asma , Feminino , Humanos , Peróxido de Hidrogênio , Hipersensibilidade , Masculino , Pessoa de Meia-Idade , Filogenia , Adulto Jovem
16.
Ther Umsch ; 76(6): 293-299, 2019 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-31762417

RESUMO

Allergy assessment: when and how? Abstract. Allergies are common in the clinical practice. The most important allergens are pollen, house dust mites, animal dander, mold and allergens attributable to a particular work environment. The medical history is a very important part for diagnosing an allergy, because sensitizations detected by skin prick tests and laboratory tests are common but not always symptomatic and therefore without clinical relevance. There are 3 options to manage allergic diseases: avoidance of allergens, symptomatic treatment and - in selected cases - a causal treatment like allergen-specific immunotherapy.


Assuntos
Alérgenos/imunologia , Hipersensibilidade , Antígenos de Dermatophagoides , Reações Cruzadas , Humanos , Hipersensibilidade/diagnóstico , Testes Cutâneos/métodos
18.
Immunity ; 51(5): 949-965.e6, 2019 11 19.
Artigo em Inglês | MEDLINE | ID: mdl-31653482

RESUMO

Mast cells (MCs) are versatile immune cells capable of rapidly responding to a diverse range of extracellular cues. Here, we mapped the genomic and transcriptomic changes in human MCs upon diverse stimuli. Our analyses revealed broad H3K4me3 domains and enhancers associated with activation. Notably, the rise of intracellular calcium concentration upon immunoglobulin E (IgE)-mediated crosslinking of the high-affinity IgE receptor (FcεRI) resulted in genome-wide reorganization of the chromatin landscape and was associated with a specific chromatin signature, which we term Ca2+-dependent open chromatin (COC) domains. Examination of differentially expressed genes revealed potential effectors of MC function, and we provide evidence for fibrinogen-like protein 2 (FGL2) as an MC mediator with potential relevance in chronic spontaneous urticaria. Disease-associated single-nucleotide polymorphisms mapped onto cis-regulatory regions of human MCs suggest that MC function may impact a broad range of pathologies. The datasets presented here constitute a resource for the further study of MC function.


Assuntos
Cromatina/genética , Suscetibilidade a Doenças , Estudo de Associação Genômica Ampla , Genômica , Mastócitos/imunologia , Mastócitos/metabolismo , Biomarcadores , Células Cultivadas , Cromatina/metabolismo , Montagem e Desmontagem da Cromatina , Fibrinogênio/genética , Fibrinogênio/metabolismo , Perfilação da Expressão Gênica , Genômica/métodos , Histonas/metabolismo , Humanos , Hipersensibilidade/etiologia , Hipersensibilidade/metabolismo , Imunoglobulina E/imunologia , Inflamação/etiologia , Inflamação/metabolismo , Polimorfismo de Nucleotídeo Único
19.
Life Sci ; 236: 116790, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31626791

RESUMO

AIMS: Although the bulk of research into the biology of serotonin 5-HT2A receptors has focused on its role in the CNS, selective activation of these receptors in peripheral tissues can produce profound anti-inflammatory effects. We previously demonstrated that the small molecule 5-HT2 receptor agonist (R)-2,5-dimethoxy-4-iodoamphetamine [(R)-DOI] inhibits TNF-α-mediated proinflammatory signaling cascades and inflammation via 5-HT2A receptor activation and prevents the development of, and inflammation associated with, acute allergic asthma in a mouse ovalbumin (OVA) model. Here, we investigated the ability of (R)-DOI to reverse inflammation and symptoms associated with established asthma in a newly developed model of chronic asthma. METHODS: An 18-week ovalbumin challenge period was performed to generate persistent, chronic asthma in BALB/c mice. Four once daily intranasal treatments of (R)-DOI were administered one week after allergen cessation, with respiratory parameters being measured by whole-body plethysmography (WBP). Cytokine and chemokine levels were measured by quantitative real-time polymerase chain reaction (qRT-PCR) in homogenized lung tissue, bronchoalveolar (BALF) fluid was analyzed for chemokine modulation by multiplex assays, and Periodic Acid-Schiff and Masson's Trichrome staining was performed to determine goblet cell infiltration and overall changes to lung morphology. KEY FINDINGS: 5-HT2 activation via (R)-DOI attenuates elevated airway hyperresponsiveness to methacholine, reduces pulmonary inflammation and mucus production, and reduces airway structural remodeling and collagen deposition by nearly 70%. SIGNIFICANCE: Overall, these data provide support for the therapeutic potential of (R)-DOI and 5-HT2 receptor activation for the treatment of asthma, and identifies (R)-DOI as a novel therapeutic compound against pulmonary fibrosis.


Assuntos
Remodelação das Vias Aéreas/efeitos dos fármacos , Anfetaminas/farmacologia , Asma/tratamento farmacológico , Pneumonia/prevenção & controle , Receptores 5-HT2 de Serotonina/metabolismo , Agonistas do Receptor 5-HT2 de Serotonina/farmacologia , Remodelação das Vias Aéreas/imunologia , Animais , Asma/induzido quimicamente , Asma/imunologia , Asma/patologia , Doença Crônica , Feminino , Hipersensibilidade/imunologia , Hipersensibilidade/patologia , Hipersensibilidade/prevenção & controle , Camundongos , Camundongos Endogâmicos BALB C , Ovalbumina/toxicidade , Pneumonia/imunologia , Pneumonia/patologia
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