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1.
Am J Clin Hypn ; 64(1): 53-61, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34748460

RESUMO

Hypnosis is a hetero-induced or self-induced altered state of consciousness that involves focused attention and reduced peripheral awareness. It is determined by response to suggestions and can be used in the management of various clinical conditions. Nowadays there is growing attention to the neurobiological correlates of hypnosis because of its future clinical applications. The greater attention is due to the wide range of applications that might stem from its knowledge. Functional neuroimaging studies show that hypnosis affects attention by modulating the activation of the anterior cingulate cortex and other brain areas, modifying the conflict monitoring and cognitive control. During hypnoanalgesia, several changes in brain functions occur in all the areas of the pain network, and other brain areas. Among these, the anterior cingulate cortex is significantly involved in modulating the activity of pain circuits under hypnosis, both in the affective, sensory-cognitive, and behavioral aspects. The study of the functionality of the cingulate cortices, mainly the anterior and medial portions, appears to be crucial for better understanding the hypnotic phenomena, related to both the neurocognitive and somatosensory aspects.


Assuntos
Giro do Cíngulo , Hipnose , Encéfalo/diagnóstico por imagem , Humanos , Hipnose Anestésica , Sugestão
2.
Am J Clin Hypn ; 64(1): 36-52, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34748461

RESUMO

Exploring psychophysiological changes during hypnosis can help to better understand the nature and extent of the hypnotic phenomenon by characterizing its influence on the autonomic nervous system (ANS), in addition to its central brain effects. Hypnosis is thought to induce a relaxation response, yet studies using objective psychophysiological measures alongside hypnosis protocols show various results. We review this literature and clarify the effects of hypnosis on psychophysiological indices of ANS activity and more specifically of the stress/relaxation response, such as heart rate variability and electrodermal activity. Studies reporting psychophysical measures during hypnosis were identified by a series of Pubmed searches. Data was extracted with an interest for the influence of hypnotizability and effects of specific suggestions or tasks on the findings. We found 49 studies comprising 1315 participants, 45 concerning healthy volunteers and only 4 on patients. Sixteen compared high vs. low hypnotizable people; 30 measured heart rate, 18 measured heart rate variability, 25 electrodermal activity, and 23 respiratory signals as well as other physiological parameters. Globally, results converge to show reductions in sympathetic responses and/or increases in parasympathetic tone under hypnosis. Several methodological limitations are underscored, such as older studies (N = 16) using manual analyses, small sample sizes (<30, N = 31), as well as uncontrolled multiple comparisons. Nevertheless, we confirm that hypnosis leads to a physiological relaxation response and highlight promising avenues for this research. Suggestions are made for guiding future work in this field.


Assuntos
Hipnose , Sistema Nervoso Autônomo , Frequência Cardíaca , Humanos , Psicofisiologia , Sugestão
3.
Am J Clin Hypn ; 64(1): 4-11, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34748462

RESUMO

Most of the experimental investigations on hypnosis used to compare small samples of individuals with low or high responsiveness to hypnosis by systematically excluding medium responders. The present article underlines the limitations of this methodological approach that may have partially weakened the scientific impact of hypnosis research. In fact, the mediums-neglecting bias might be one of the reasons why some investigations suffer from low replicability and generalizability. Themes such as hypnotizability scales, suggestibility, statistical power, and research design are critically reviewed with the aim of proposing a more rigorous approach that boost up impact and reliability of hypnosis research. In particular, the recruitment of medium hypnotizables and the adoption of a within-instead of a between-subjects design currently seem to be some of the best recommendations for strengthening hypnosis research, as well as to renew the dialogue between clinical and experimental hypnosis.


Assuntos
Hipnose , Humanos , Reprodutibilidade dos Testes , Sugestão
4.
Am J Clin Hypn ; 64(1): 62-80, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34748463

RESUMO

Chronic pain is a complex phenomenon which includes biological, psychological, and socio-professional factors that undermine patients' everyday life. Currently, only few patients significantly benefit from pharmacological treatments and many have to stop them because of negative side effects. Moreover, no medication or treatment addresses all aspects of chronic pain at once (i.e., sensations, emotions, behaviors, and cognitions), positioning chronic pain as an important public health issue and thus contributing to high health-care costs. Consequently, patients and health-care providers are increasingly turning to complementary non-pharmacological techniques such as hypnosis. Clinical research has demonstrated a decrease of pain perception, pain interference, depression and anxiety, and an increase in global quality of life when patients with chronic pain have benefited from hypnosis learning. Neuroimaging studies offer a possible explanation of these results by focusing on neural processes of pain modulation in chronic pain patients' brain. Studies conducted with chronic pain patients showed a modulation of pain matrix activity during hypnosis with a specific involvement of the anterior cingulate cortex (related to emotional and cognitive processing of pain). Therefore, hypnosis seems to act upon regions underlying emotion and cognition, with an influence on pain perception and emotional regulation. In this review, we propose to carry out a review of the recent literature on hypnosis in chronic pain management. A better understanding of the beneficial effects of hypnosis on chronic pain and its neurophysiology should enable more systematic use of this technique in the management of this complex health problem.


Assuntos
Dor Crônica , Hipnose , Ansiedade , Dor Crônica/terapia , Humanos , Manejo da Dor , Qualidade de Vida
5.
Am J Clin Hypn ; 64(1): 20-35, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34748464

RESUMO

The history of hypnosis has been marked by its effectiveness paralleled by prejudicial refusal, due to its ostensible incompatibility with the ruling Weltbild (picture of the world). Its interpretation has been mainly based on concepts like suggestibility, dissociation, hallucination, impairment of sense of agency, and free will. Nevertheless, little evidence and agreement has been reached so far on the nature of hypnosis and hypnotic ability, an uncertainty enhanced by the wide range of meanings and ambiguities of the used terms. This article analyzes the main epistemological implications involved in the topic.


Assuntos
Hipnose , Hipnóticos e Sedativos , Humanos , Conhecimento , Sugestão
6.
Am J Clin Hypn ; 64(1): 12-19, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34748465

RESUMO

Many medical conditions are claimed to benefit when hypnosis is incorporated into their treatment. For some conditions, the claims are largely anecdotal, but the treatment of pain stands out in two ways. First, there is a strong body of evidence that hypnosis can produce clinically useful analgesic effects. Second, since innocuous pain can be induced in the laboratory, the process can be explored rigorously. This idea assumes that experimentally induced pain and clinical pain behave identically. We describe using experimentally induced pain in patients already suffering from temporomandibular disorders. Scanning results indicate that the pain and its amelioration are the same in the two circumstances. Moreover, the absence of any impact upon a nociceptive trigemino-facial reflex implies that the impact of hypnosis is purely cortical. Finally, we address the observation that clinical success correlates poorly with hypnotic susceptibility scores. It is proposed that a painful experimental situation induces anxiety. This, like hypnosis, has been associated with an emphasis on right hemisphere activity. Thus, clinical anxiety may render a person more responsive to hypnosis than would be indicated by a susceptibility test delivered in stress-free circumstances.


Assuntos
Analgesia , Hipnose , Transtornos da Articulação Temporomandibular , Humanos , Hipnóticos e Sedativos , Dor , Medição da Dor , Transtornos da Articulação Temporomandibular/terapia
7.
J Healthc Eng ; 2021: 1418281, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34691371

RESUMO

The objective of this paper is to study the curative effect of music combined with hypnosis on labor pains during childbirth. Based on the algorithm of data mining, we randomly selected 100 women who delivered babies in obstetric units from October 2020 to June 2021, set the control group and the observation group, obtained the relevant clinical data through comparison, and analyzed the value of music combined with hypnotic analgesia midwifery in obstetrics. The results showed that the number of spontaneous delivery cases in the observation group was higher than that in the control group (P < 0.05) and the delivery time in the observation group was better than that in the control group (P < 0.05). It is proved that music combined with hypnosis can effectively improve the rate of natural childbirth and shorten the overall labor time, so as to guarantee the health of mother and child.


Assuntos
Analgesia , Hipnose , Trabalho de Parto , Música , Mineração de Dados , Feminino , Humanos , Recém-Nascido , Gravidez
8.
Complement Ther Clin Pract ; 45: 101486, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34601386

RESUMO

BACKGROUND AND PURPOSE: Pain is a common condition among people with hemophilia (PWH), negatively impacting quality of life. However, effective treatment remains a challenge. This two-arm, parallel randomized controlled pilot trial aimed to examine the three-month effects of hypnosis intervention on clinical and psychosocial variables, and on the inflammatory profile of PWH. MATERIALS AND METHODS: The study was conducted between January and October 2018, in a Reference Center for Congenital Coagulopathies. Adult (age ≥18) patients were randomized to experimental group (EG) or control group (CG). The EG received four weekly hypnosis sessions plus treatment-as-usual, and the CG maintained treatment-as-usual only. Outcomes were evaluated at one week and three months post-intervention and included pain, joint status, health-related quality of life (HRQoL), emotional state and inflammatory profile (leukocytes, C-reactive protein, cytokines). The randomization sequence was computer-generated, and allocation was concealed until enrolment. The outcome assessor was blind to allocation, but blinding of the participants was not possible due to the differences in procedure. RESULTS: Twenty patients were randomized to EG (n = 10; 8 analyzed) or CG (n = 10; 10 analyzed). Two-way mixed ANOVA showed significant time × group interactions on pain interference with normal work and with relations with other people, and on perception of health status. The EG significantly improved in pain interference with normal work and perception of health status. There was no report of harm. CONCLUSION: Hypnosis may be a promising intervention to manage hemophilia-related pain and promote HRQoL, with benefits lasting up to three months.


Assuntos
Hemofilia A , Hipnose , Adulto , Hemofilia A/terapia , Humanos , Dor/etiologia , Projetos Piloto , Qualidade de Vida
9.
Aliment Pharmacol Ther ; 54(11-12): 1389-1404, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34591988

RESUMO

BACKGROUND: Individual hypnotherapy (IH) is a recognised treatment for irritable bowel syndrome (IBS). However, it is not widely available to patients due to its resource-intensive nature, lack of adequately trained therapists, and scepticism about hypnosis. Non-individualised hypnotherapy approaches, such as group and self-help hypnotherapy, could maximise existing therapist resources by treating more patients at the same time, thus widening patient access to treatment without incurring additional expenditure. AIMS: To investigate the research literature for non-individualised approaches to hypnotherapy for IBS and to determine their effectiveness for reducing symptom severity and/or providing adequate relief. METHODS: A literature review of published peer-reviewed studies was conducted. Quantitative research was selected to determine the effectiveness of the interventions. RESULTS: Ten studies were eligible for inclusion. Three delivered group hypnotherapy, three integrated hypnosis within a group concept, and four utilised a self-help home hypnotherapy treatment using audio recordings. Both group hypnotherapy for adults and the self-help home hypnotherapy treatment for children were effective interventions that may be non-inferior to IH for patients with mild-to-moderate symptoms. Treatment benefits were long-lasting. The evidence for the integrative group concept and home treatment for adults was less compelling. CONCLUSIONS: Group hypnotherapy for adults, and self-help hypnotherapy for children, may be cost-effective treatments that can widen access for patients with milder IBS in primary care settings. Further research is needed to determine the effectiveness of group hypnotherapy for patients with severe, refractory IBS.


Assuntos
Hipnose , Síndrome do Intestino Irritável , Adulto , Criança , Acesso aos Serviços de Saúde , Humanos , Síndrome do Intestino Irritável/terapia , Seleção de Pacientes , Autocuidado
10.
Sante Publique ; Vol. 33(1): 113-120, 2021 Jun 24.
Artigo em Francês | MEDLINE | ID: mdl-34372630

RESUMO

INTRODUCTION: A short training course in therapeutic communication based on hypnosis techniques and by simulation was developed at the Simulation Center of the Metropolitan Hospital Center of Savoy, France. The training, based on practical exercises, took place in a 2 + 1 format: two days in a row and then a third day at remotely, allowing different acquired techniques to be placed in field situation.Purpose of research: The main objective of this study was to evaluate the effectiveness of training on how caregivers feel about patients with pain or anxiety. Secondary objectives were to evaluate the training and to measure the impact of the training on caregiver behavior. RESULTS: 24 sessions bringing together a total of 419 professionals (mainly doctors, nurses and nursing assistants) took place between 2016 and 2019. The training and the trainers were evaluated very positively by the participants. The understanding and willingness to set up therapeutic communication was high. Between the beginning and the end of the training, thanks to the simulation that allows learning in the conditions of care, the participants noted an improvement in their capacities and feelings as well as a reduction in their stress when faced with delicate care situations. CONCLUSIONS: Starting from the patient, from his state of consciousness, using the right communication tools : these approaches make it possible to improve the quality, the perceived care, but will also be useful in all other clinical situations and should be taught to all caregivers.


Assuntos
Hipnose , Médicos , Cuidadores , Comunicação , Emoções , Humanos
11.
Neurourol Urodyn ; 40(8): 1945-1954, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34420228

RESUMO

AIMS: To evaluate the feasibility and acceptability of a randomized controlled trial of a hypnosis intervention for the treatment of bladder pain syndrome/interstitial cystitis (BPS/IC) in women. METHODS: We conducted a parallel arm, non-blinded, pilot randomized controlled trial of standardized hypnosis sessions including a hypnosis web tool versus usual care in adult women with BPS/IC. Pilot study outcomes included feasibility domains: process, resources and management, safety, and acceptability. Clinical outcomes of lower urinary tract symptoms and quality of life were measured using validated questionnaires at baseline and at the end of the 4-week intervention. RESULTS: We randomized 29 out of 30 (96.7%) eligible women. In the hypnosis group, 12 of 15 (80.0%) subjects completed the 4-week intervention and follow up, and 13 of 14 (92.9%) in the usual care group. In the hypnosis group, adherence to the standardized sessions was 80% and participants used the web-based tool for an average of 5.6 ± 2.7 times per week. Scores for emotional distress, relaxation, pain severity and expected bladder symptoms significantly improved during the first two of three planned hypnosis sessions (all p < 0.05). Improvement in quality of life scores was greater in the hypnosis group than the usual care group (-2.6 ± 2.3 vs. -0.9 ± 1.1, p = 0.04). There were no significant between-group differences in urinary symptoms or bladder pain. No adverse events were reported. CONCLUSIONS: A hypnosis intervention for the treatment of bladder pain syndrome/interstitial cystitis is feasible, acceptable, safe, and may improve quality of life.


Assuntos
Cistite Intersticial , Hipnose , Adulto , Cistite Intersticial/terapia , Feminino , Humanos , Dor Pélvica , Projetos Piloto , Qualidade de Vida
12.
J Am Dent Assoc ; 152(9): 756-762, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34332655

RESUMO

BACKGROUND AND OVERVIEW: Hypnosis, despite its effectiveness, has been neglected. The aim of this study is to show the effectiveness and manageability of hypnosis as a stand-alone technique in dentistry. CASE DESCRIPTION: Three patients underwent 6 oral surgery procedures (surgical third-molar removal, implant surgery, maxillary bone augmentation, and mucogingival surgery) with hypnosis as the only anesthetic. Two of the 3 patients had difficulties: 1 was sensitive to multiple chemicals, had Addison disease, and had previously experienced anaphylactic reactions to local anesthetics; the other was allergic to lidocaine and had undergone a paradoxical reaction to pharmacologic sedation in the past. All 3 patients had 2 preoperative sessions each to assess their perioperative risk, level of anxiety, hypnotic susceptibility, and capacity to develop full hypnotic analgesia. On a surgery day, hypnosis was induced and hypnotic analgesia was obtained according to a standard protocol, a procedure taking no more than 9 minutes in each case. Each surgical procedure was then completed successfully with the patient in a painless condition of full relaxation and sense of well-being, with stable cardiovascular parameters. None of the patients required postoperative analgesics, which were prescribed for use as needed. CONCLUSIONS AND PRACTICAL IMPLICATIONS: Hypnosis is a valuable tool in dentistry, enabling the safe and rapid relief of anxiety and phobia and raising patient pain thresholds to the level of surgical analgesia. Unlike drugs and equipment, it is always readily available, cost-free, and has no adverse effects when administered by competent professionals. Hypnosis can be used for sedation in most patients and as a stand-alone technique in those with appropriate hypnotic susceptibility, improving the well-being and safety of patients.


Assuntos
Anestesia Dentária , Hipnose , Anestesia Dentária/efeitos adversos , Anestésicos Locais , Humanos , Medição da Dor , Extração Dentária
14.
Complement Ther Clin Pract ; 44: 101431, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34198240

RESUMO

OBJECTIVE: To determine whether the participation to a medical hypnosis training program reduces the levels of burnout in healthcare providers. DESIGN: Survey study. SETTINGS: Study conducted from 2014 to 2018 using the MBI-HSS questionnaire assessing three dimensions of burnout: emotional exhaustion (EE), depersonalization (DP) and personal accomplishment (PA). PARTICIPANTS: Healthcare providers in particular anesthesiologists participating to a one-year medical hypnosis training program. INTERVENTION: All participants were asked to fill the MBI-HSS on the first day before the training program had begun, then on the last day of the program once the entire training was completed. PRIMARY AND SECONDARY OUTCOME MEASURES: The EE, DP and PA scores and their grade (high, average and low) were compared before and after training and between physicians and caregivers. RESULTS: In total, 1850 persons participated to the training sessions, with 1366 participants enrolled before the first session (74%) and 1407 (76%) after the fourth. On the 1366 persons enrolled before training, 1139 (83%) completed the survey and on the 1407 enrolled after training, 1194 (85%) completed the survey. The scores were significantly smaller after training for EE and DP and significantly greater for PA. Before training, EE was significantly greater in physicians than in caregivers as well as DP, with no difference for PA. After training, DP was significantly greater in physicians than in caregivers and PA was smaller, with no difference for EE. Before training, there was high rates of burnout in both healthcare providers but there was a significant trend to smaller rates of burnout after training. CONCLUSIONS: This study shows that healthcare providers who participated to a medical hypnosis training program presented improvements in the three dimensions of burnout. Further study is required to investigate and recommend this type of continuous medical education to improve professional satisfaction and wellbeing in healthcare providers.


Assuntos
Anestesiologistas , Hipnose , Esgotamento Psicológico , Pessoal de Saúde , Humanos , Inquéritos e Questionários
15.
Herz ; 46(4): 336-341, 2021 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-34309699

RESUMO

With a growing acceptance of clinical hypnosis in medicine, new fields of application are being explored. Data from recent studies support the use of hypnosis for pain management during procedures, such as ablation of arrhythmias and implantation of subcutaneous implantable cardioverter defibrillators, management of preoperative anxiety and reduction of postoperative atrial fibrillation. The aim of this review article is to summarize the findings of investigations showing the application of hypnosis in the field of cardiac electrophysiology, to review the rationale for the efficacy of hypnosis in management of cardiac arrhythmias and to highlight possible future directions in clinical applications and scientific perspectives.


Assuntos
Fibrilação Atrial , Desfibriladores Implantáveis , Hipnose , Técnicas Eletrofisiológicas Cardíacas , Humanos
16.
Acta Biomed ; 92(S2): e2021027, 2021 07 29.
Artigo em Inglês | MEDLINE | ID: mdl-34328143

RESUMO

Background Much evidence shows that hypnotic communication can have a pain-relieving effect and reduce complications such as anxiety, insomnia and depression. Whenever this technique was applied, the use of pharmaceuticals was reduced, there were less side effects, shorter hospitalization timesframes and lower treatment costs. Aim of the study Evaluate the knowledge and perceptions of nurses about hypnotic communication and the causes for which this technique is not frequently used. A secondary objective pointed to measuring the effectiveness of an educational event on hypnosis. Method The evaluation was done by administering an anonymous and voluntary survey, in a pre-test and post-test modality to nurses subscribed to a formative event on hypnotic communication organized by the Nursing Order, Province of Ravenna. Results 78 nurses participated in the study. The analysis of the pre-test results show a gap of knowledge regarding hypnotic communication. The main causes were found regarding the lack of use for hypnotic communication: stereotypes and prejudices related to this technique and insufficient university education. Conclusions The implementation of this technique, effective and efficient under various aspects, requires a preliminary creation of culture regarding this theme, capable of surpassing the stereotypes and resistances brought by a lack of theoretical elements.


Assuntos
Hipnose , Comunicação , Humanos , Conhecimento , Dor , Percepção
17.
Clin Obstet Gynecol ; 64(3): 635-647, 2021 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-34323237

RESUMO

Hypnosis, the induction of a naturally relaxed state of mind and body, is most commonly practiced by pregnant women in preparation for the childbirth experience. A literature review was performed to assess the effects of hypnosis before, during and after pregnancy. The majority of data is extracted from case series and low-quality studies thereby limiting the acceptability of hypnosis for various pregnancy related conditions. A few well-designed studies show that self-hypnosis may be beneficial for mitigating labor pain and fear of childbirth. Women can safely pursue hypnotherapy during pregnancy; however, high quality trials are needed to demonstrate its complete efficacy.


Assuntos
Hipnose , Dor do Parto , Obstetrícia , Feminino , Humanos , Dor do Parto/terapia , Gravidez
18.
Gastroenterol Clin North Am ; 50(3): 581-593, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34304789

RESUMO

Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction (DGBI) that is associated with significant physical, emotional, and occupational burden. Factors such as early life stress, sleep disruption, maladaptive coping strategies, symptom hypervigilance, and visceral hypersensitivity negatively affect gut-brain communication and increase the likelihood of developing IBS or worsen IBS severity. Behavioral strategies, such as cognitive behavioral therapy, gut-directed hypnosis, and mindfulness-based treatments, have shown benefit in improving gastrointestinal (GI)-specific quality of life, as well as reducing GI symptoms. Partnering with a GI-specific mental health provider can assist gastroenterologists in providing comprehensive treatment of IBS and other DGBIs.


Assuntos
Hipnose , Síndrome do Intestino Irritável , Atenção Plena , Encéfalo , Humanos , Síndrome do Intestino Irritável/terapia , Qualidade de Vida
19.
Minerva Anestesiol ; 87(11): 1255-1267, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34263590

RESUMO

Despite the huge development of pain management in the past decades, pain remains elusive and many patients still remain in the middle of the ford struggling between low drug efficacy and their overuse. A reason for pain elusiveness is its nature of subjective phenomenon, escaping the meshes of the objectivist, mechanist-reductionist net prevailing in medicine. Actually, pain is not only a symptom but an essential aspect of life, consciousness and contact with the world and its noetic and autonoetic components play a key role in the development of the concepts of pleasure-unpleasure and good-evil. The intensity and tolerability of pain and suffering also depend on what the pain means to the patient. The outstanding effects of placebo and nocebo, behavioral and non-pharmacological techniques warrant the need for a shift from the traditional positivist idea of patient as passive carrier of disease to the patient as active player of recovery and move toward a patient's centered approach exploiting individual resources for recovery. Among the mentioned techniques, hypnosis has proved to increase pain threshold up to the level of surgical analgesia, improve acute and chronic pain as well as coping and resilience, helping to decrease both drug overuse and the costs of pharmacological therapy. The plethora of available data suggests the need for a holistic approach, aiming to take care of the individual as an inseparable mind-body unit in its interplay with the environment, where patient's inner world, his/her experience and cognition are taken into due account as powerful resources for recovery through a phenomenological-existential approach.


Assuntos
Hipnose , Dor , Feminino , Humanos , Masculino
20.
Molecules ; 26(11)2021 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-34072024

RESUMO

Overweight, obesity, and psychiatric disorders are serious health problems. To evidence the anxiolytic-like effects and lipid reduction in mice receiving a high-calorie diet and Bertholletia excelsa seeds in a nonpolar extract (SBHX, 30 and 300 mg/kg), animals were assessed in open-field, hole-board, and elevated plus-maze tests. SBHX (3 and 10 mg/kg) potentiated the pentobarbital-induced hypnosis. Chronic administration of SBHX for 40 days was given to mice fed with a hypercaloric diet to determine the relationship between water and food intake vs. changes in body weight. Testes, epididymal white adipose tissue (eWAT), and liver were dissected to analyze fat content, triglycerides, cholesterol, and histological effects after administering the hypercaloric diet and SBHX. Fatty acids, such as palmitoleic acid (0.14%), palmitic acid (21.42%), linoleic acid (11.02%), oleic acid (59.97%), and stearic acid (7.44%), were identified as constituents of SBHX, producing significant anxiolytic-like effects and preventing body-weight gain in mice receiving the hypercaloric diet without altering their water or food consumption. There was also a lipid-lowering effect on the testicular tissue and eWAT and a reduction of adipocyte area in eWAT. Our data evidence beneficial properties of B. excelsa seeds influencing global health concerns such as obesity and anxiety.


Assuntos
Ansiedade/metabolismo , Bertholletia/metabolismo , Lipídeos/química , Sobrepeso/metabolismo , Sementes , Tecido Adiposo Branco/metabolismo , Animais , Peso Corporal , Sistema Nervoso Central , Ingestão de Alimentos , Epididimo/metabolismo , Ácidos Graxos/metabolismo , Hipnose , Masculino , Aprendizagem em Labirinto , Camundongos , Pentobarbital , Testículo/metabolismo
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