Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 17.629
Filtrar
1.
Bratisl Lek Listy ; 121(1): 96-101, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31950845

RESUMO

Vaclav Trnka from Krovice (1739-1791, in Latin: Wenzel Trnka Krzowitz) was a remarkable physician whose life serves as an example in the history of medicine by connecting major capital cities of Central Europe. In view of current geographical layout, he was born and brought up in the Czech Republic, graduated from University of Vienna in Austria, and was appointed Professor of the Anatomy at the newly established Faculty of Medicine of University of Nagyszombat, presently Trnava in Slovak Republic. When the University moved to Buda and later to Pest (today Budapest, Hungary), he was the first educator to introduce anatomy as a medical subject to be taught in a Hungarian medical school. He also was elected the Dean of Faculty of Medicine three times and in 1786-1787 he acted as Rector of then the Royal University of Pest. During his life, he published twenty-seven monographs dealing with different areas of clinical medicine, such as malaria (intermittent fever), diabetes, and rickets. Based on these monographs we can proclaim that Václav Trnka was a co-founder of modern infectology, diabetology and ophthalmology in Central Europe. Nowadays, artificial intelligence and bioinformatics are inseparable parts of modern health care system which help the transformation of big data into valuable knowledge. In the 18th century, Professor Trnka owned more than 3,000 scientific books and had natural, innate intelligence and wisdom which made him a real "medical polymath". As a musician, Trnka also composed sixty-one canons, two of them long wrongly considered as Mozart's work. Despite the fact that Trnka is considered to be the founder of Hungarian anatomy education and a major medical figure of the eighteenth century Central Europe, no internationally acclaimed biographical record of his life or work has so far been published in English. Therefore, we would like to reintroduce Václav Trnka both as an anatomist and medical polymath, and to give an overview of the early days of anatomy teaching in present-day Slovakia and Hungary (Fig. 1, Ref. 27). Keywords: Trnka from Krovice, anatomist, medical polymath, history of medicine.


Assuntos
Anatomistas , Anatomistas/história , República Tcheca , Europa (Continente) , História do Século XVIII , Humanos , Hungria , Eslováquia
2.
J Insect Sci ; 20(1)2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31925424

RESUMO

Urbanization has a significant impact on abiotic and biotic factors in nature. We examined the morphometric characters of four carabid species (Abax parallelepipedus, Carabus scheidleri, Carabus violaceus, and Pterostichus oblongopunctatus) along urbanization gradients in and around the cities of Vienna (Austria) and Debrecen (Hungary). We found significant differences among urban, suburban, and rural areas in the parameters of antennomers, the maxillary palpus, the labial palpus, and the length of the tibia and the elytra of the carabids studied. We also found significant differences between males and females based on the parameters of antennomers, the maxillary palpus, the labial palpus, the femur, and the elytra. An interaction between urbanization and sex was found in the case of antennomers, the maxillary palpus, the labial palpus, the femur, and the elytra. Our findings suggested that in the cases of species from Carabini tribus the parameters of antennomers, the maxillary palpus, and the elytra could be useful for assessing the effects of urbanization because these morphometric characters responded sensitively to the environmental stress, whereas the most useful parameters are those of antennomers and the tibia for the species of Pterostichini tribus. Our findings also revealed that females are more sensitive to environmental stress than males.


Assuntos
Besouros/anatomia & histologia , Urbanização , Animais , Áustria , Cidades , Feminino , Hungria , Masculino , Especificidade da Espécie
3.
Orv Hetil ; 161(3): 83-94, 2020 Jan.
Artigo em Húngaro | MEDLINE | ID: mdl-31928058

RESUMO

Renal cell carcinoma (RCC) represents a heterogenous group of malignant tumors that originate from the kidney parenchyma. The different entities have their own specific epidemiological, morphological, immunohistochemical, genetic and clinical characteristics. The new WHO classification of renal tumors was published in 2016, and it takes all of these features together into account. Although in the past three years, several emerging subtypes have been described, these are not yet included in the current classification. In this review paper, these entities are summarized in details including the following emerging subsets: thyroid-like follicular carcinoma, ALK rearrangement-associated RCC, renal cell carcinoma with prominent smooth muscle stroma, fumarate hydratase-deficient RCC, biphasic squamoid papillary RCC, eosinophilic solid and cystic RCC, atrophic kidney-like RCC, clear cell RCC with giant cells and emperipolesis, Warthin-like papillary RCC, low-grade oncocytic renal tumor (CD117-negative; CK7-positive), high-grade oncocytic renal tumor, TCEB1-mutated RCC and chromophobe RCC with neuroendocrine features. These entities are mostly diagnosed as RCC unclassified. The aim of this study is to introduce these subsets to the Hungarian pathologists, oncologists and urologists, to prompt diagnostic accuracy and to facilitate a collection along with a consecutive analysis of these cases. Orv Hetil. 2020; 161(3): 83-94.


Assuntos
Carcinoma de Células Renais , Neoplasias Renais , Biomarcadores Tumorais , Humanos , Hungria , Rim
4.
Orv Hetil ; 161(3): 103-109, 2020 Jan.
Artigo em Húngaro | MEDLINE | ID: mdl-31928060

RESUMO

Introduction: Autologous hemopoietic stem cell transplantation remains a promising therapy in certain malignant and non-malignant conditions. The procedure, however, will increase the risk of complications, most notably early and late infections. Aim: To analyze the frequency and spectrum of pathogens in early (<+100 days) post-transplant infections and to evaluate risk factors for mortality. Method: Prospectively collected data from 699 patients undergoing autologous hemopoietic stem cell transplantation between 2007 and 2014 at our center were retrospectively reviewed and analyzed. Results: The median age of 699 patients was 56 (interquartile range: 43-62) years, 54% (376) were male. 25 patients have been transferred to other centers and 19 patients were lost to follow up. Neutropenic fever occurred in 69.8% (488) of patients. In addition, 102 infectious episodes in 96 patients were identified. Most commonly bacteremia occurred (49 episodes) with a median onset of 7 (5-11) days. The majority (33/49) of bacteremias have been observed during the pre-engraftment period. Their incidence proved to be higher in patients with malignant lymphoma compared to individuals with plasma cell disorders (p = 0.0005, OR: 2.41, 95% CI: 1.49-3.99). 12 episodes of viral infections and 8 cases of proven or probable invasive mycoses have been identified. Among the 655 patients with complete follow up, 16 in-hospital deaths (2.4%) occurred, 8 of them were associated with infections. Survival was adversely affected by early infections (p = 0.0001). Conclusion: In autologous stem cell transplantation, microbiologically unconfirmed neutropenic fever is common. Documented early bacteremia, however, is infrequent. Lymphoma patients have a significantly higher chance to develop bloodstream infections compared to individuals with plasma cell disorders. Early infections decrease the chance of survival; thus, an effective prophylaxis and therapy remains of paramount importance. Orv Hetil. 2020; 161(3): 103-109.


Assuntos
Infecções Bacterianas/epidemiologia , Infecções Bacterianas/microbiologia , Febre/etiologia , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Neutropenia/microbiologia , Transplante Autólogo/efeitos adversos , Adulto , Infecções Bacterianas/mortalidade , Febre/epidemiologia , Humanos , Hungria/epidemiologia , Linfoma , Masculino , Pessoa de Meia-Idade , Neutropenia/epidemiologia , Estudos Retrospectivos
5.
Orv Hetil ; 161(4): 151-160, 2020 Jan.
Artigo em Húngaro | MEDLINE | ID: mdl-31955583

RESUMO

Introduction: The prevalence of overweight and obesity is increasing worldwide, which affects not only adults, but children and adolescents as well. Moreover, this condition may lead to several comorbidities, such as elevated or even high blood pressure. Aim: Aim of this study was to assess the prevalence of overweight- and obesity-related elevated and high blood pressure in a population aged 3-18 years in Hungary. Method: Between 2005 and 2018, altogether 8624 (boys = 4719) individuals were enrolled to this study. Normal weight, overweight and obese groups were created on the basis of body mass index. The diagnosis of elevated (systolic and/or diastolic blood pressure is between 90th and 95th percentile) and high blood pressure (systolic and/or diastolic blood pressure is over 95th percentile) was based on detailed examination (laboratory tests, abdominal ultrasonography, paediatric cardiology and 24-hours ambulatory blood pressure monitoring). Results: In this study, the prevalence of overweight and obesity was 23.5% overall, 26.4% in boys and 20% in girls. The prevalence of elevated blood pressure was 9.8% in overweight patients, while it was 4.6% in the obese group. The prevalence of high blood pressure was 8.3% (odds ratio: 1.1%, 95% CI) among overweight subjects, while it was 26.7% (odds ratio: 3.6, 95% CI) in the obese group. Conclusion: To the best of our knowledge, this is the first Hungarian population-based study on the prevalence of overweight- and obesity-related elevated and high blood pressure assessed in a large contemporary cohort of children and adolescents. The cardiovascular risk is increased in this patient group. Hence, it is essential to set up a proper primary prevention strategy. Orv Hetil. 2020; 161(4): 151-160.


Assuntos
Hipertensão/epidemiologia , Obesidade Pediátrica/epidemiologia , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Hungria/epidemiologia , Masculino , Prevalência
6.
Orv Hetil ; 161(1): 11-16, 2020 Jan.
Artigo em Húngaro | MEDLINE | ID: mdl-31884812

RESUMO

Introduction: There are no satisfying data about the difficulties of nutritional therapy during rehabilitation, but malnutrition and secondary sarcopenia increase the number of complications. Aim: The aim of this cross-sectional study was measuring of patients' malnutrition risk in the National Institute for Medical Rehabilitation of Hungary. Method: Malnutrition Universal Screening Tool was used in this study. Results: 44% of the patients had a risk of malnutrition (n = 331; average age: 59 years), 19% of the patients presented moderate risk and 25% had high risk of malnutrition. The sample consisted of 176 males and 155 females (53%/47%). The interquartile range of body mass index of patients was between 22-29.9 kg/m2 (s = 6.36). Comparison of units showed that the Brain Injury Rehabilitation Unit has the most malnutrition-risked patients (62.5%, 25 patients). Conclusions: Malnutrition screening tools are not sensitive enough in the case of special patient groups of rehabilitation, therefore a combined screening method is needed. Orv Hetil. 2020; 161(1): 11-16.


Assuntos
Pacientes Internados , Desnutrição/diagnóstico , Programas de Rastreamento/métodos , Sarcopenia , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Feminino , Humanos , Hungria , Masculino , Desnutrição/prevenção & controle , Pessoa de Meia-Idade , Avaliação Nutricional , Estado Nutricional
7.
Orv Hetil ; 161(1): 3-10, 2020 Jan.
Artigo em Húngaro | MEDLINE | ID: mdl-31884813

RESUMO

The rapidly evolving field of repetitive transcranial magnetic stimulation as a neuromodulational technique may mean a safe, alternative approach to the management of several mental disorders, especially treatment-resistant major depressive disorder. Our aim is to describe the current role of transcranial magnetic stimulation in research and routine clinical practice, based on the literature and clinical protocols. Since the discovery, that an outer magnetic source can depolarize neurons, both neurology and psychiatry seek the method's possible clinical utility. To date, in the field of psychiatry, the method is only approved in the treatment of major depressive disorder and obsessive-compulsive disorder, but research continues to find application in other mental disorders (schizophrenia, bipolar disorder), too. The next step in the evolution of repetitive transcranial magnetic stimulation is based on magnetic resonance guided, real-time navigation with the help of positioning algorithms. The so-called neuronavigational systems make precise aiming of neuronal circuits responsible for the development of depression, thus increasing the excitability of the left dorsolateral prefrontal cortex and decreasing it on the right hemisphere. The method has few contraindications, and the occurrence of side effects can be minimized by carefully selected patient population. For today, transcranial magnetic stimulation became an evidence-based, effective treatment for some mental disorders, especially treatment-resistant major depressive disorder. It is to be assumed that in the future neuronavigational neuromodulation techniques, including repetitive transcranial magnetic stimulation, will be widely used in the field of psychiatry and neurology. Magnetic stimulation is currently available in a number of centres in Hungary, but the financial approval and the implementation of this neuromodulation method for treating mental disorders in the everyday clinical practice are still in progress. Orv Hetil. 2020; 161(1): 3-10.


Assuntos
Transtorno Depressivo Maior/terapia , Estimulação Magnética Transcraniana/métodos , Transtorno Depressivo Maior/psicologia , Humanos , Hungria , Córtex Pré-Frontal , Estimulação Magnética Transcraniana/efeitos adversos , Resultado do Tratamento
8.
Orv Hetil ; 161(1): 17-25, 2020 Jan.
Artigo em Húngaro | MEDLINE | ID: mdl-31884814

RESUMO

Introduction: Herbal medicine use has become widespread in recent years. This is the first study in Hungary evaluating the use of nutraceutical agents in patients undergoing elective surgery. Aim: The aim of this study was to assess the types, frequency of use and predisposing factors of the most commonly used herbs among patients of an urban hospital and a university clinic. Method: We conducted an anonymous survey questionnaire at the Jávorszky Ödön Hospital and at the 1st Department of Surgery of Semmelweis University. A total of 1000 questionnaires were distributed. Results: In total, 612 questionnaires were returned. 34.3% of patients used herbal remedies, 19.6% of them two weeks prior to surgery. The most commonly used herbs were garlic, chamomile and lemongrass, while in the two-week period before surgery were garlic, ginger and rosehips. 58.5% of the patients had some type of co-morbidity; in this group, the use of herbal remedies was significantly more frequent. 64.4% of patients were expected to undergo general surgical intervention; in this group, the use of herbs was more popular. Analyzing the sociodemographic factors, women, people with a higher level of education, the ones that live in the capital and are over 60 years of age are more likely to use these compounds. Conclusion: One third of patients waiting for surgery used herbal remedies, one fifth of them two weeks prior to surgery. Only one fifth of the patients reported the use of these compounds to their doctors. Orv Hetil. 2020; 161(1): 17-25.


Assuntos
Procedimentos Cirúrgicos Eletivos , Medicina Herbária , Fitoterapia , Feminino , Hospitais Universitários , Hospitais Urbanos , Humanos , Hungria , Pessoa de Meia-Idade , Assistência Perioperatória , Plantas Medicinais , Inquéritos e Questionários
9.
Magy Onkol ; 63(4): 275-280, 2019 Dec 09.
Artigo em Húngaro | MEDLINE | ID: mdl-31821382

RESUMO

Systematic, structured and longitudinal collection of realtime Big Patient Data and the analysis of aggregated diagnostic, therapeutic and therapy response data of onco-hematologic patients leads to the development of nationwide dynamic disease registries providing a platform for medical, health industrial and data science research, hospital and health insurance cost analysis, measurement of innovative diagnostics and therapeutics performance, evaluation of compassion-based treatments and general support for insurance and health policy decisions. First in Hungary, we developed a complex computerized case management, data collection, processing, and analysis program (OncoGenomic) and a self-learning artificial intelligence (AI) precision medicine decision support application (Oncompass Calculator) that organize basic research (R), applied research and development (R and D) and innovation (I) under a common umbrella. These progams support the national dynamic hematologic disease registry. Exchange of data through the Electronic Health Service Space (EESZT) supports equal opportunity access of patients to innovative diagnostics and therapy.


Assuntos
Inteligência Artificial , Neoplasias Hematológicas , Tomada de Decisão Clínica , Humanos , Hungria , Medicina de Precisão , Software
10.
Orv Hetil ; 160(50): 1984-1989, 2019 Dec.
Artigo em Húngaro | MEDLINE | ID: mdl-31814421

RESUMO

Introduction: Moyers mixed dentition analysis is one of the most commonly used prediction methods to estimate the size of the unerupted teeth. By its use, we can determine the severity of tooth size-arch length discrepancies in mixed dentition. Since the tooth size may vary considerably among different ethnic groups, for the most precise estimation of the required space, an analysis based on the individual's own ethnic group would be recommended. Aim: Our aim was to evaluate the applicability of Moyers mixed dentition analysis for the Hungarian population. Method: Upper and lower study casts of 370 patients were evaluated. The mesiodistal widths of the teeth were measured by using a Pittsburgh digital caliper. The odontometric values obtained were used to calculate actual and predicted values. The actual teeth measurements were then statistically compared to the predicted values derived from Moyers probability tables. Results: Using Moyers analysis, we found significant differences at each percentile between the actual and predictive values in both sexes. In the upper jaw, values for men at the 95th, 85th, 75th, and 65th percentile overestimated the actual values, while for women only the 65th percentile underestimated it. In the lower jaw, all values were overestimated in relation to the actual measurements at all percentiles. Conclusions: Based on our results, Moyers mixed dentition analysis cannot be reliably applied for the Hungarian population. If used, it is recommended to use the Moyers predicted values at the 65th instead of the 75th percentile, as this will result in closer estimation to the actual space requirements. Orv Hetil. 2019; 160(50): 1984-1989.


Assuntos
Dente Canino , Dentição Mista , Dente Pré-Molar , Feminino , Humanos , Hungria , Masculino , Odontometria
11.
Orv Hetil ; 160(50): 1967-1975, 2019 Dec.
Artigo em Húngaro | MEDLINE | ID: mdl-31814422

RESUMO

Use of 3D planning and 3D printing is expanding in healthcare. One of the common applications is the creation of anatomical models for the surgical procedure from DICOM files. These patient-specific models are used for multiple purposes, including visualization of complex anatomical situations, simulation of surgical procedures, patient education and facilitating communication between the different disciplines during clinical case discussions. Cardiac and thoracic surgical applications of this technology development include the use of patient-specific 3D models for exploration of ventricle and aorta function and surgical procedural planning in oncology. The 3D virtual and printed models provide a new visualization perspective for the surgeons and more efficient communication between the different clinical disciplines. The 3D project was started at the Semmelweis University with the cooperation of the Thoracic Surgery Department of the National Institute of Oncology in 2018. The authors want to share their experiences in 3D designed medical tools. Orv Hetil. 2019; 160(50): 1967-1975.


Assuntos
Modelos Anatômicos , Assistência Perioperatória , Impressão Tridimensional , Humanos , Hungria
12.
Orv Hetil ; 160(50): 1990-1998, 2019 Dec.
Artigo em Húngaro | MEDLINE | ID: mdl-31814423

RESUMO

Introduction: Recent research findings support the assumption that the development of chronic diseases in adults is greatly influenced by the supply of nutrients in the uterus and the nutrition, nourishment of the early, toddler ages. Aim: The aim of the present study was to evaluate the nutritional habits of infants and toddlers aged 0-3 in Hungary, and to identify the most typical problems of their nutrition, to get to know and provide the necessary data for the modification and modernization of feeding/nutrition recommendations for infants and young children in Hungary. Method: The study was carried out with the professional coordination of the Hungarian Dietetic Association (MDOSZ) in the framework of industry research between June and August 2015, in the 0-3-year-old population, in the cities Budapest, Debrecen, Gyor, Szeged and Pécs. The survey was conducted with anthropometric measurements and validated by three-day dietary log templates. Results: 18.6% of infants aged 4 to 12 months (n = 220) had values below 10th percentile, 10% were between 85-97th percentiles and 3% were above 97th percentile. 15% of children aged 12-24 months (n = 227) had a body mass index (BMI) below 10th percentile (underweight), 14% were between 85-97th percentile (overweight) and 2.6% had BMI over the 97th percentile (obese). 70% of 25-36-month-old children (n = 184) had normal BMI, 4% were overweight, 2% obese, 24% underweight. Based on the Hungarian reference value, 10.9% of the 4-12-month-old children, 20% of the 1-2-year-olds, 47% of the 2-3-year-olds were in high protein intake group. However, compared to the 2013's reference values of the EFSA (European Food Safety Authority) recommendation, 100% of the children belong to the high protein intake group in all age groups. Conclusion: Although the EFSA recommendation - based on the WHO/FAO/UNU macro- and micronutrient intake values in 2007 - defines the recommended intake quantities, the results in the sample did not support its overall reliability. Orv Hetil. 2019; 160(50): 1990-1998.


Assuntos
Avaliação Nutricional , Estado Nutricional , Adulto , Pré-Escolar , Feminino , Humanos , Hungria , Lactente , Recém-Nascido , Micronutrientes , Reprodutibilidade dos Testes
13.
Orv Hetil ; 160(51): 2021-2025, 2019 Dec.
Artigo em Húngaro | MEDLINE | ID: mdl-31838861

RESUMO

Introduction: Wilson's disease is a lethal-without-treatment inherited disorder of copper metabolism. Despite the increased focus on the diagnosis and treatment, liver transplantation is needed in a number of cases even nowadays. Aim: To collect and analyze the data of the Hungarian Wilson's disease patients who underwent liver transplantation. Method: Data of 24 Wilson's disease patients who underwent liver transplantation at the Semmelweis University have been analyzed retrospectively. The diagnosis of Wilson's disease was based on the international score system. The diagnosis of acute liver failure corresponded to the King's College criteria. All liver transplantations had been performed at the Department of Transplantation and Surgery of Semmelweis University, in 1996 for the first time. Results: The mean age was 26 years, F/M = 13/11. Twelve patients needed urgent liver transplantation for acute liver failure, and 12 underwent transplantation for decompensated liver cirrhosis. One patient had been retransplanted because of chronic rejection. Three patients with acute on chronic liver failure were transplanted via the Eurotransplant program. The mean time on the waiting list was 3 vs 320 days in acute liver failure and chronic liver disease groups, respectively. The overall 5-year survival was 66%, but it was 80% after 2002 indicating both the learning curve effect and the improvement of vigilance in Hungary. Despite difficulties of the diagnostic process, Wilson's disease was identified in 21/24 patients prior to the transplantation. Conclusion: Liver transplantation is needed in a number of cases of Wilson's disease. The ideal indication and timing of transplantation may improve the survival of the patients. Orv Hetil. 2019; 160(51): 2021-2025.


Assuntos
Degeneração Hepatolenticular/cirurgia , Cirrose Hepática/complicações , Transplante de Fígado , Adulto , Feminino , Degeneração Hepatolenticular/mortalidade , Degeneração Hepatolenticular/patologia , Humanos , Hungria , Fígado/patologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Taxa de Sobrevida , Resultado do Tratamento
14.
Orv Hetil ; 160(51): 2026-2035, 2019 Dec.
Artigo em Húngaro | MEDLINE | ID: mdl-31838862

RESUMO

Introduction: According to the European Centre for Disease Prevention and Control, the prevalence of neuroinvasive symptoms caused by the West Nile virus (WNV) has significantly increased in the past years throughout Europe, including Hungary. The rise may be attributed to changes in precipitation and climate. The WNV zoonosis is spread by mosquitoes. It is mostly asymptomatic, flu-like symptoms occur in 20% of the cases and in less than 1% a neuroinvasive disease with a lethal outcome may develop. Aim: Our aim was to demonstrate the neuroinvasive symptomatology and the diagnosis and treatment of WNV infections by describing our patient cases as well as to resolve differential diagnostic dilemmas. Method: We report the cases of 4 patients treated at the "Moritz Kaposi" Somogy County Hospital between the 31st July and 4th September, 2018, with WNV, whose diagnoses were confirmed by serological and molecular biological methods. An epidemiological overview of WNV infections was also given. Results: Four patients were confirmed to have had WNV infection in the given time period. A wide range of neurological symptoms were observed in each patient and death occurred in one case. The patients were elderly with a number of comorbidities. Conclusions: The appearance of more severe, neuroinvasive symptoms following WNV infections is also characteristic of Hungary. The treatment of the infection is supportive, including giving pain relievers and the management of secondary infections. It is important to consider the possibility of a WNV infection in the case of a neurological disease of unknown origin, particularly if the symptoms indicate encephalitis. Orv Hetil. 2019; 160(51): 2026-2035.


Assuntos
Serviço Hospitalar de Emergência/estatística & dados numéricos , Encefalite Viral/epidemiologia , Febre do Nilo Ocidental/diagnóstico , Vírus do Nilo Ocidental/isolamento & purificação , Idoso , Animais , Anticorpos Antivirais/sangue , Humanos , Hungria/epidemiologia , Prevalência , Febre do Nilo Ocidental/epidemiologia
15.
Orv Hetil ; 160(51): 2036-2039, 2019 Dec.
Artigo em Húngaro | MEDLINE | ID: mdl-31838863

RESUMO

Here we report on a severe, neonatal onset epileptic encephalopathy manifested in a currently 2-year-old boy with no family history of neurological disease. Extensive clinical investigations were unable to clarify the etiology of the infant's condition characterized by drug-resistant seizures and markedly delayed developmental skills. As in this class of disorders a genetic cause might be identified, a next-generation sequencing (NGS) epilepsy panel examination consisting of 128 genes was initiated for a correct diagnosis. The genetic analysis identified a previously undescribed hemizygous missense mutation in the MECP2 gene. Similarly to other, X-linked dominant disorders, Rett syndrome was originally hypothesized to be lethal in males. This theory, however, has been revised. The aim of this report is to review the wide spectrum of neurodevelopmental diseases observed in male patients carrying mutations in the MECP2 gene classically associated with Rett syndrome in girls. To the author's knowledge, this is the first report in Hungary to document MECP2 mutation of a male patient diagnosed by molecular genetic testing. Orv Hetil. 2019; 160(51): 2036-2039.


Assuntos
Retardo Mental Ligado ao Cromossomo X/genética , Proteína 2 de Ligação a Metil-CpG/genética , Mutação/genética , Síndrome de Rett/genética , Pré-Escolar , Humanos , Hungria , Masculino , Retardo Mental Ligado ao Cromossomo X/diagnóstico , Retardo Mental Ligado ao Cromossomo X/fisiopatologia , Biologia Molecular , Fenótipo , Síndrome de Rett/fisiopatologia
16.
Orv Hetil ; 160(49): 1941-1947, 2019 Dec.
Artigo em Húngaro | MEDLINE | ID: mdl-31786937

RESUMO

Introduction and aim: To analyse and classify the ocular trauma cases at the in-patient ophthalmological department of the Markusovszky University Teaching Hospital between 2014 and 2018. Method: We analysed the eye injury cases between 01. 01. 2014 and 31. 12. 2018 in the in-patient clinic of our hospital. 98 eyes of 97 patients were included in this study. To classify the injuries, we used the Birmingham Eye Trauma Terminology (BETT) and the new expanded classification of Shukla et al. Results: From the 97 patients, 16 were female and 81 male. The average age was 43.3 ± 22.5 (min.: 3, max.: 92) years; 20 patients were younger than 18 years old. 46.4% of the cases were right eyes, 52.5% were left eyes, and 1% was bilateral. The average time from the injury until the treatment was 1.3 days. The average time spent in hospital because of the injury was 5.2 days. The average observation time was 9.7 months. 95.8% of the injuries were mechanical eye injuries. From this group, 74.2% localized only to the globe, 20.4% were adnexal injuries and 5.4% were destructive eye injuries. From the globe injuries, 15 were closed globe, 60 were open globe injuries, and in 21 cases there were intraocular foreign body present. In 93% of the cases it was possible to keep or improve the best corrected visual acuity during the treatment. Conclusion: With the new classification, we could classify all of the eye injury cases easily. Depending on the type of the eye injury, with appropriate treatment we can keep or improve the visual function of the eye. Orv Hetil. 2019; 160(49): 1941-1947.


Assuntos
Traumatismos Oculares/classificação , Pacientes Internados/estatística & dados numéricos , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Traumatismos Oculares/epidemiologia , Traumatismos Oculares/etiologia , Feminino , Departamentos Hospitalares , Hospitais Universitários , Humanos , Hungria/epidemiologia , Masculino , Pessoa de Meia-Idade , Acuidade Visual
17.
Orv Hetil ; 160(49): 1948-1956, 2019 Dec.
Artigo em Húngaro | MEDLINE | ID: mdl-31786940

RESUMO

Introduction: The organized breast and cervical screening programs were implemented in the framework of public health program in Hungary in order to reduce breast cancer mortality by 30% and cervical cancer mortality by 60% in given age groups within 10 years by 2012. Aim: The aim of our study was to conduct a retrospective analysis of mortality and morbidity data and to evaluate the effectiveness of the implemented screening programs. Method: Descriptive statistical analysis was performed by age-standardized mortality and morbidity data between 1980 and 2015 with special regard to the period of 2002-2012. Results: Breast cancer mortality of women aged 45-64 reduced by 28.3%, the incidence reduced by 23.6% and the incidence of in situ carcinoma increased by 242% between 2002 and 2012. Cervical cancer mortality of women aged 25-64 years reduced by 25.5%, the incidence reduced by 21.2%, and the incidence of in situ carcinoma increased by 13.3% during 2002-2012. Conclusion: Although both breast cancer and cervical cancer mortality substantially decreased in Hungary, the decrease in cervical cancer did not reach the target value. Orv Hetil. 2019; 160(49): 1948-1956.


Assuntos
Neoplasias da Mama/mortalidade , Detecção Precoce de Câncer/estatística & dados numéricos , Programas de Rastreamento/estatística & dados numéricos , Neoplasias do Colo do Útero/mortalidade , Adulto , Idoso , Neoplasias da Mama/diagnóstico , Detecção Precoce de Câncer/métodos , Feminino , Humanos , Hungria/epidemiologia , Pessoa de Meia-Idade , Estudos Retrospectivos , Taxa de Sobrevida , Neoplasias do Colo do Útero/diagnóstico
18.
Ideggyogy Sz ; 72(11-12): 381-388, 2019 Nov 30.
Artigo em Húngaro | MEDLINE | ID: mdl-31834681

RESUMO

The 123I-FP-CIT dopamine transporter SPECT imaging is a sensitive method to assess functional dopaminergic neuron terminals in the striatum. The method has also been available in Hungary for years. There are two main indications: (i) to help differentiate essential tremor from clinically uncertain Parkinsonism, including patients with early symptoms and (ii) to help differentiate dementia with Lewy bodies from Alzheimer's disease. The aim of this paper is to review 123I-FP-CIT SPECT imaging based on international data/guidelines and our own experiences, thereby assisting nuclear medicine practitioners and neurologists.


Assuntos
Doença de Alzheimer/diagnóstico por imagem , Proteínas da Membrana Plasmática de Transporte de Dopamina , Doença por Corpos de Lewy/diagnóstico por imagem , Tomografia Computadorizada de Emissão de Fóton Único/métodos , Tropanos , Doença de Alzheimer/metabolismo , Humanos , Hungria , Doença por Corpos de Lewy/metabolismo , Sensibilidade e Especificidade
19.
Ideggyogy Sz ; 72(11-12): 389-396, 2019 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-31834682

RESUMO

Background and purpose: The aim of this study was to compare ischemic stroke subtypes with the effects of risk factors, the relationship between grades of kidney disease and the severity of stroke subtypes. Methods: The current study was designed retrospectively and performed with data of patients who were hospitalised due to ischemic stroke. We included 198 subjects who were diagnosed with ischemic stroke of Grade 3 and above with chronic kidney disease. Results: In our study were reported advanced age, coronary artery disease, moderate kidney disease as the most frequent risk factors for cardioembolic etiology. Hypertension, hyperlipidemia, smoking and alcohol consumption were the most frequent risk factors for large-artery disease. Female sex and anaemia were the most frequent risk factors for small-vessel disease. Dialysis and severe kidney disease were the most frequent risk factors in unknown etiologies, while male sex, diabetes mellitus, prior stroke and mild kidney disease were the most frequent risk factors for other etiologies. National Institute of Health Stroke Scale (NIHSS) scores were lower for small-vessel disease compared with other etiologies. This relation was statistically significant (p=0.002). Conclusion: In order to improve the prognosis in ischemic stroke with chronic kidney disease, the risk factors have to be recognised and the treatment options must be modified according to those risk factors.


Assuntos
Isquemia Encefálica/complicações , Insuficiência Renal Crônica/complicações , Acidente Vascular Cerebral/complicações , Consumo de Bebidas Alcoólicas/epidemiologia , Isquemia Encefálica/epidemiologia , Feminino , Humanos , Hungria/epidemiologia , Hiperlipidemias/epidemiologia , Hipertensão/epidemiologia , Masculino , Insuficiência Renal Crônica/epidemiologia , Estudos Retrospectivos , Fatores de Risco , Fumar/epidemiologia , Acidente Vascular Cerebral/epidemiologia
20.
Ideggyogy Sz ; 72(11-12): 413-418, 2019 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-31834685

RESUMO

Background and purpose: Background - The research of alexithymia - the inability to express or understand emotions - has recently become of great importance in clinical practice, mainly in the field of doctor-patient and psychologist patient communication. Many studies have proven the correlation between alexithymia and the development of functional somatic symptoms, i.e. somatization. Purpose - The aim of this clinical study was to examine the emotion-recognition and emotion communication patterns of patients suffering from chronic pain (e.g., headache, low back pain, arthralgia, neuropathy). Moreover, the participants received access to the Hungarian adaptation of a new international online educational site (www.retrainpain.org) dealing with pain management. Methods: Data were collected from the Headache and Chronic Pain Outpatient Clinic, Department of Neurology, Faculty of Medicine, University of Szeged, Hungary (tertiary care - Group 1) and from a general practice in district 2, Budapest, Hungary (primary care - Group 2) from March, 2017 to April, 2018. Patients received a test package containing a pain-specific questionnaire, then the Difficulties in Emotion Regulation Scale (DERS), the Toronto Alexithymia Scale (TAS-20), and the shortened Hungarian version of the WHO-Well-being (WBI-5) had to be completed. After filling out the questionnaires, all patients got access to the Hungarian adaptation of the www.retrainpain.org website. Results: Altogether 92 patients participated in the study (Group 1 n=50; Group 2 n=42). Based on the TAS-20 re-sults, 35 patients reached a pathological score (≥60 points), which indicates the diagnosis of alexithymia. The mean TAS-score was lower in Group 2 (primary care) than in Group 1 (tertiary care) (p=0.003). The DERS disclosed pathological results in 19 cases (p=0.009). As regards the www.retrainpain.org chapters, we received feedback only from 25 out of 92 patients (27%) (Group 1 n=20; Group 2 n=5). Conclusion: Although the examined patients have been suffering from different chronic pain syndromes for years and 50% of them confirmed that symptoms placed at least moderate or heavy burden on their everyday life, the available educational programme was studied only by a smaller proportion of patients than expected. Additionally, those who surveyed the Hungarian adaptation of the www.retrainpain.org website were mainly patients from primary care (Group 2), in spite of the fact that patients from specialized medical care (Group 1) had worse subjective conditions. Our future objective is to extend our database with follow-up results and to improve patients' response willingness.


Assuntos
Dor Crônica , Internet , Manejo da Dor/métodos , Educação de Pacientes como Assunto , Sintomas Afetivos , Comunicação , Emoções , Cefaleia , Humanos , Hungria , Inquéritos e Questionários
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA