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1.
Int J Hyperthermia ; 39(1): 1044-1051, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-35940593

RESUMO

PURPOSE: To analyze the clinical safety and efficacy of 3.0-T closed MR-guided microwave ablation (MWA) for the treatment of HCC located under the hepatic dome. METHODS: From May 2018 to October 2020, 49 patients with 74 HCCs located under the hepatic dome underwent MWA using 3.0-T closed MR guidance. The technical success rate, operative time, complete ablation (CA) rate, complications, local tumor progression (LTP), tumor-free survival (TFS) and overall survival (OS) were examined. Routine blood analysis, liver/kidney function and alpha fetoprotein (AFP) and protein induced by vitamin k absent or antagonist (PIVKA) levels were compared before and 2 months after MWA. RESULTS: All patients underwent MWA successfully, including 10 patients who underwent general anesthesia. The technical success rate was 100% without major complications. The CA rate was 95.9% (71/74) at the 2-month evaluation. The LTP rate was 2.7% during the median follow-up of 17.8 months (range: 4-43 months); the 6-, 12-, 18-month TFS rates were 97.8, 90.6, 68.1%, respectively, and the 6-, 12-, 18-month OS rates were 100, 97.6, 92.1%, respectively. There were no significant changes in routine blood tests and liver/kidney function (p > 0.05), while the AFP and PIVKA level decreased significantly at 2 months (p < 0.05). CONCLUSION: 3.0-T MR-guided MWA is safe and feasible for HCC lesions located under the hepatic dome.


Assuntos
Carcinoma Hepatocelular , Ablação por Cateter , Neoplasias Hepáticas , Carcinoma Hepatocelular/patologia , Humanos , Neoplasias Hepáticas/patologia , Micro-Ondas/uso terapêutico , Estudos Retrospectivos , Resultado do Tratamento , alfa-Fetoproteínas
2.
Food Res Int ; 159: 111617, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35940808

RESUMO

This study aimed to investigate how infrared (1000-2000 W) and microwave power (100-900 W), air velocity (1-5 m/s) and temperature (40-80 °C) affected the specific energy consumption, the moisture removal rate, and the product's quality (whiteness index, head rice yield, water uptake ratio, and elongation ratio) in hybrid dryer. Rising temperature, velocity and microwave power and lower temperatures resulted in improving head rice yield of paddy samples. The experiments proved that the new hybrid system significantly increased the moisture removal rate (from 100 to 700%), head rice yield (from 5 to 40 %) and decreased the specific energy consumption (from 10 to 80%) compared to the single fluidized bed dryer. The water uptake ratio and elongation ratio of the dried samples in the hybrid dryer were higher than the single dryer, however their whiteness index was not significantly different. The best drying conditions are associated with the lowest specific energy consumption and the highest moisture removal ratio and rice quality. Experimental data were fitted into empirical drying models to explain moisture ratio variations during drying. Nomhorm and verma,s model was found to be the best for moisture ratio prediction. Also, the central composite design of response surface methodology was applied to forecast outputs. A modified cubic model was observed in all responses with high R2 values (greater than0.9). The drying parameters were optimized for the specified constraints, resulting in 68 °C temperature, 5 m/s air velocity, 900 w microwave power, and 1479 w infrared power. The experimental values were found to be 0.368607 g/s for the moisture removal rate, 7.16988 MJ/kg water for the specific energy consumption, 90.6% for the head rice yield, 58 for the whiteness index, 3.63 for the water uptake ratio, and 2.28627 for the elongation ratio, at the optimum treatment conditions.


Assuntos
Micro-Ondas , Oryza , Manipulação de Alimentos/métodos , Modelos Teóricos , Água/análise
3.
Food Res Int ; 159: 111643, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35940816

RESUMO

Trichosanthes kirilowii Maxim seed is a primary source of edible vegetable oil and possesses a high nutritional value, making them extremely beneficial to humanity. To promote the extraction process of Trichosanthes kirilowii Maxim seed oil, the effect of microwave heating time (700 W for 0, 2, 4, and 6 min) on lipid composition, chemical properties, and antioxidant activity of oils was studied. The results showed that the oil yield of the seed increased with the microwave heating time. Besides, microwave heating time significantly affects (p < 0.05) DPPH and tocopherols, and the IC50 value of DPPH was highest with microwave heating for 6 min, whatever the shells are reserved. The tocopherol content was highest with microwave heating for 2 min in the seed shell oil, which was 1930.60 mg/kg. The longer microwave heating time could improve the oil yield and antioxidant activity of Trichosanthes kirilowii Maxim seed oil. The seed shell also affects chemical properties, fatty acid composition, antioxidant activity, and tocopherol contents of the Trichosanthes kirilowii Maxim seed oil. The Trichosanthes kirilowii Maxim seed shell oil has higher DPPH and tocopherols contents than seed kernel oil, while seed kernel oils showed higher oil yield and acid value. Our finding is valuable for manufacturers to choose suitable means to produce Trichosanthes kirilowii Maxim seed oil of required qualities and chemical compositions for targeted use.


Assuntos
Trichosanthes , Antioxidantes/análise , Calefação , Micro-Ondas , Óleos Vegetais/análise , Sementes/química , Tocoferóis/análise , Trichosanthes/química
4.
Food Res Int ; 159: 111663, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35940820

RESUMO

French fries are popular items in the diets of many countries, but the high oil content is a major health concern for consumers. Numerous novel frying techniques have been explored by the fast food service industry and the research community to address such concern. This research aimed to study the influence of microwave heating at two frequencies (2.45 and 5.85 GHz), both individually or in combination, in frying and post-frying on oil reduction in French fries. Results showed that microwave frying reduced the frying time by 30 - 40%, with equivalent product quality attributes in terms of oil content, color, and texture, as compared to deep-oil frying. Oil intake increased with increasing moisture loss during frying, regardless of the frying methods. Post-frying condition was the key to oil reduction. Specifically, a 60 s microwave heating after frying reduced the oil content by 18 - 23%. Compared to 2.45 GHz, microwaves at 5.85 GHz could produce French fries with significantly lower oil content (p ≤ 0.05) and better quality attributes such as color and texture. This study demosntrated the potential of microwave heating in production of deep-fried French fries with lower oil content and better quality.


Assuntos
Micro-Ondas , Solanum tuberosum , Culinária/métodos , Fast Foods , Indústria de Processamento de Alimentos
5.
Biomater Adv ; 138: 212940, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35913238

RESUMO

Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease without effective treatment. Tofacitinib (TOF) is a JAK inhibitor that can be used for RA therapy, but it still faces the problems of nonspecific distribution and relatively low therapeutic effect. Herein, ICAM-1-modified TOF-loaded P(AN-co-AAm)-PEG micelles (AI-TM) were developed, which can result in an enhanced RA therapy when combining with microwave hyperthermia (MH). It was found that AI-TM could rapidly release the encapsulated TOF under a thermal condition of >43 °C, which was due to the fact that the polymeric micelles has an upper critical solution temperature (UCST) of 43 °C. AI-TM could specifically distribute into the inflamed joints of RA mice, which is associated with the high affinity between anti-ICAM-1 and overexpressed ICAM-1 receptors. Moreover, the combination of AI-TM and MH could result in a remarkably enhanced anti-rheumatic activity, which was related to the RA-targeted ability of AI-TM, the rapid TOF release under MH, and the combined effect between TOF and MH treatment. Our study definitely provides a novel strategy for effective treatment of RA.


Assuntos
Artrite Reumatoide , Hipertermia Induzida , Animais , Artrite Reumatoide/tratamento farmacológico , Camundongos , Micelas , Micro-Ondas , Piperidinas , Pirimidinas
6.
Sci Adv ; 8(31): eabo5285, 2022 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-35921425

RESUMO

Microwave ablation (MWA) as a local tumor ablation strategy suffers from posttreatment tumor recurrence. Development of adjuvant biomaterials to potentiate MWA is therefore of practical significance. Here, the high concentration of Ca2+ fixed by alginate as Ca2+-surplus alginate hydrogel shows enhanced heating efficiency and restricted heating zone under microwave exposure. The high concentration of extracellular Ca2+ synergizes with mild hyperthermia to induce immunogenic cell death by disrupting intracellular Ca2+ homeostasis. Resultantly, Ca2+-surplus alginate hydrogel plus MWA can ablate different tumors on both mice and rabbits at reduced operation powers. This treatment can also elicit antitumor immunity, especially if synergized with Mn2+, an activator of the stimulation of interferon genes pathway, to suppress the growth of both untreated distant tumors and rechallenged tumors. This work highlights that in situ-formed metallo-alginate hydrogel could act as microwave-susceptible and immunostimulatory biomaterial to reinforce the MWA therapy, promising for clinical translation.


Assuntos
Neoplasias Hepáticas , Micro-Ondas , Alginatos , Animais , Hidrogéis/farmacologia , Neoplasias Hepáticas/patologia , Camundongos , Micro-Ondas/uso terapêutico , Coelhos , Resultado do Tratamento
7.
BMJ Case Rep ; 15(8)2022 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-35918079

RESUMO

We present a rare complication of microwave ablation (MWA) in a male patient in his 80s. His massive pulmonary necrosis and tension pneumothorax required urgent surgery. However, the damage to the lung tissue was too large, deep and fragile. We failed to suture or conduct wedge resection on the lung lesion, so, left upper lobectomy was necessary. Therefore, we suggest that it is probably possible to reduce the frequency and time threshold when performing MWA for the elderly with comorbidities.


Assuntos
Ablação por Cateter , Neoplasias Pulmonares , Idoso , Idoso de 80 Anos ou mais , Ablação por Cateter/efeitos adversos , Humanos , Pulmão/diagnóstico por imagem , Pulmão/patologia , Pulmão/cirurgia , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/cirurgia , Masculino , Micro-Ondas/efeitos adversos , Necrose/etiologia , Necrose/cirurgia , Octogenários
8.
Int J Hyperthermia ; 39(1): 822-828, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35786169

RESUMO

OBJECTIVE: To assess the effect and safety of subpleural multisite anesthesia based on the area of thermal radiation during CT-guided lung malignancy microwave ablation (MWA) on the incidence of moderate or severe pain and the analgesic drug usage. MATERIALS AND METHODS: Consecutive patients with lung malignancies were retrospectively evaluated between January 2016 and December 2019. Patients undergoing CT-guided lung malignancy MWA were either given in the method of (a) standard subpleural puncture point anesthesia between January 2016 and June 2018 and (b) subpleural multisite anesthesia based on the area of thermal radiation between July 2018 and December 2019. The relationship between local anesthesia mode and moderate or severe pain, and pain medications usage was assessed by using multivariable logistic regression models. RESULTS: A total of 243 consecutive patients were included in the study. Moderate or severe pain occurred in 84 of 124 (67.7%) patients with subpleural puncture point anesthesia and in 20 of 119 (16.8%) patients with subpleural anesthesia in the area of thermal radiation (p=.001). The intravenous pain medication was required in 56 of 124 (45.2%) patients with subpleural puncture point anesthesia and in 9 of 119 (7.6%) patients with subpleural multisite anesthesia based on the area of thermal radiation (p=.001). Local anesthesia methods (p = 0.001), pleura-to-lesion distance (p=.02) and tumor size (p=.015) were independent risk factors for developing moderate or severe pain. There were no differences in adverse events and local tumor progression rate. CONCLUSIONS: Subpleural multisite anesthesia based on the area of thermal radiation for peripheral lung malignancy MWA can result in lower intraprocedural pain compared with the subpleural puncture point anesthesia. Thus, a subpleural multisite anesthesia technique may be most helpful when performing MWA of peripheral malignancy in patients who are not sedated with general or intravenous anesthesia.


Assuntos
Anestésicos , Ablação por Cateter , Neoplasias Pulmonares , Ablação por Cateter/métodos , Humanos , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/radioterapia , Micro-Ondas/uso terapêutico , Dor/etiologia , Pleura/patologia , Pleura/cirurgia , Estudos Retrospectivos , Tomografia Computadorizada por Raios X
9.
Sci Rep ; 12(1): 11941, 2022 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-35831357

RESUMO

Vegetable oils, whose hydrocarbon structure is very similar to that of petroleum products, are ideal renewable and sustainable alternatives to petroleum lubricants. Bio-lubricants are commonly synthesized by modifying the chemical structure of vegetable oils. In this study, microwave irradiation was applied to intensify the mass-transfer-limited transesterification reaction to produce trimethylolpropane triester (bio-lubricant) from camelina oil as a promising local energy crop. A rotatable RSM-BBD method was applied to find the optimal levels of experimental factors, namely reaction time (67.8 min), the catalyst concentration (1.4 wt%) and the molar ratio (3.5). In these optimal levels, the reaction yield of 94.3% was obtained with desirability of 0.975. The quadratic statistical model with a determination coefficient of 97.97%, a standard deviation of 0.91 and a variation coefficient of 1% was suggested as the most appropriate model by Design-Expert software. Finally, the physicochemical properties of the purified product were in accordance with the requirements of the ISO-VG22 base oil standard.


Assuntos
Lubrificantes , Petróleo , Biocombustíveis , Catálise , Lubrificantes/química , Micro-Ondas , Óleos Vegetais , Propilenoglicóis
10.
Sci Rep ; 12(1): 11562, 2022 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-35799049

RESUMO

Microwaves, long used as a convenient household appliance, have been increasingly used in industrial processes such as organic synthesis and oil processing. It has been proposed that microwaves can enhance these chemical processes via a non-thermal effect. Here we report the instantaneous effect of microwaves on the permittivity and phase velocity of light in water through the in-situ measurement of changes in refractive index. Microwave irradiation was found to reduce the water refractive index (RI) sharply. The reduction increased as a function of microwave power to a far greater extent than expected from the change in temperature. The phase velocity of light in water increases up to ~ 5% (RI of 1.27) during microwave irradiation. Upon stopping irradiation, the return to the equilibrium RI was delayed by up to 30 min. Our measurement shows that microwaves have a profound non-thermal and long-lasting effect on the properties of water. Further investigation is planned to verify if the observed RI reduction is restricted to the region near the surface or deep inside water bulk. The observation suggests a relationship between microwave-induced and the enhanced aqueous reactions.


Assuntos
Micro-Ondas , Água , Refratometria , Temperatura
11.
Sci Rep ; 12(1): 11694, 2022 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-35803961

RESUMO

The setup, operational procedures and performance of a cryogen-free device for producing hyperpolarized contrast agents using dissolution dynamic nuclear polarization (dDNP) in a preclinical imaging center is described. The polarization was optimized using the solid-state, DNP-enhanced NMR signal to calibrate the sample position, microwave and NMR frequency and power and flip angle. The polarization of a standard formulation to yield ~ 4 mL, 60 mM 1-13C-pyruvic acid in an aqueous solution was quantified in five experiments to P(13C) = (38 ± 6) % (19 ± 1) s after dissolution. The mono-exponential time constant of the build-up of the solid-state polarization was quantified to (1032 ± 22) s. We achieved a duty cycle of 1.5 h that includes sample loading, monitoring the polarization build-up, dissolution and preparation for the next run. After injection of the contrast agent in vivo, pyruvate, pyruvate hydrate, lactate, and alanine were observed, by measuring metabolite maps. Based on this work sequence, hyperpolarized 15N urea was obtained (P(15N) = (5.6 ± 0.8) % (30 ± 3) s after dissolution).


Assuntos
Imageamento por Ressonância Magnética , Ácido Pirúvico , Espectroscopia de Ressonância Magnética/métodos , Micro-Ondas , Ácido Pirúvico/química , Reprodutibilidade dos Testes
12.
Molecules ; 27(13)2022 Jun 22.
Artigo em Inglês | MEDLINE | ID: mdl-35807251

RESUMO

We investigated how different doses of microwave irradiation (MR) affect seed germination in Sorghum, including the level of remediation against textile and surgical wastewater (WW) by modulating biochemical and morpho-physiological mechanisms under glutamic acid (GA) application. The experiment was conducted to determine the impact of foliar-applied GA on Sorghum under wastewater conditions. Plants were treated with or without microwave irradiation (30 s, 2.45 GHz), GA (5 and 10 mM), and wastewater (0, 25, 50, and 100). Growth and photosynthetic pigments were significantly decreased in plants only treated with various concentrations of WW. GA significantly improved the plant growth characteristics both in MR-treated and -untreated plants compared with respective controls. HMs stress increased electrolyte leakage (EL), hydrogen peroxide (H2O2), and malondialdehyde (MDA) content; however, the GA chelation significantly improved the antioxidant enzymes activities such as ascorbate oxidase (APX), superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) both in MR-treated and -untreated plants under WW stress compared with respective controls. The results suggested that the MR-treated plants accumulate higher levels of HMs under GA addition in comparison to the WW-only-treated and MR-untreated plants. The maximum increase in Cd accumulation was observed in the range of 14-629% in the roots, 15-2964% in the stems, and 26-4020% in the leaves; the accumulation of Cu was 18-2757% in the roots, 15-4506% in the stems, and 23-4605% in the leaves; and the accumulation of Pb was 13-4122% in the roots, 21-3588% in the stems, and 21-4990% in the leaves under 10 mM GA and MR-treated plants. These findings confirmed that MR-treated sorghum plants had a higher capacity for HMs uptake under GA and could be used as a potential candidate for wastewater treatment.


Assuntos
Poluentes do Solo , Sorghum , Antioxidantes/análise , Ácido Glutâmico/análise , Peróxido de Hidrogênio/análise , Micro-Ondas , Folhas de Planta/química , Poluentes do Solo/análise , Superóxido Dismutase , Águas Residuárias/análise
13.
Molecules ; 27(13)2022 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-35807358

RESUMO

Nucleobase building blocks have been demonstrated to be strong candidates when it comes to DNA/RNA-like materials by benefiting from hydrogen bond interactions as physical properties. Modifying at the 5' position is the simplest way to develop nucleobase-based structures by transesterification using the lipase Novozym 435. Herein, we describe the optimization of the lipase-catalyzed synthesis of the monomer 5'-O-methacryloylcytidine with the assistance of microwave irradiation. Variable reaction parameters, such as enzyme concentration, molar ratio of the substrate, reaction temperature and reaction time, were investigated to find the optimum reaction condition in terms of obtaining the highest yield.


Assuntos
Lipase , Micro-Ondas , Enzimas Imobilizadas/química , Esterificação , Proteínas Fúngicas/metabolismo , Lipase/química
14.
Molecules ; 27(13)2022 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-35807493

RESUMO

Microwave-assisted synthesis is considered environmental-friendly and, therefore, in agreement with the principles of green chemistry. This form of energy has been employed extensively and successfully in organic synthesis also in the case of metal-catalyzed synthetic procedures. However, it has been less widely exploited in the synthesis of metal complexes. As microwave irradiation has been proving its utility as both a time-saving procedure and an alternative way to carry on tricky transformations, its use can help inorganic chemists, too. This review focuses on the use of microwave irradiation in the preparation of transition metal complexes and organometallic compounds and also includes new, unpublished results. The syntheses of the compounds are described following the group of the periodic table to which the contained metal belongs. A general overview of the results from over 150 papers points out that microwaves can be a useful synthetic tool for inorganic chemists, reducing dramatically the reaction times with respect to traditional heating. This is often accompanied by a more limited risk of decomposition of reagents or products by an increase in yield, purity, and (sometimes) selectivity. In any case, thermal control is operative, whereas nonthermal or specific microwave effects seem to be absent.


Assuntos
Complexos de Coordenação , Elementos de Transição , Calefação , Metais , Micro-Ondas
15.
Sensors (Basel) ; 22(13)2022 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-35808266

RESUMO

This paper proposes a novel inverse method based on the deep convolutional neural network (ConvNet) to extract snow's layer thickness and temperature via passive microwave remote sensing (PMRS). The proposed ConvNet is trained using simulated data obtained through conventional computational electromagnetic methods. Compared with the traditional inverse method, the trained ConvNet can predict the result with higher accuracy. Besides, the proposed method has a strong tolerance for noise. The proposed ConvNet composes three pairs of convolutional and activation layers with one additional fully connected layer to realize regression, i.e., the inversion of snow parameters. The feasibility of the proposed method in learning the inversion of snow parameters is validated by numerical examples. The inversion results indicate that the correlation coefficient (R2) ratio between the proposed ConvNet and conventional methods reaches 4.8, while the ratio for the root mean square error (RMSE) is only 0.18. Hence, the proposed method experiments with a novel path to improve the inversion of passive microwave remote sensing through deep learning approaches.


Assuntos
Micro-Ondas , Tecnologia de Sensoriamento Remoto , Redes Neurais de Computação , Tecnologia de Sensoriamento Remoto/métodos , Neve
16.
Sensors (Basel) ; 22(13)2022 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-35808397

RESUMO

This study assesses the efficacy of detecting colorectal cancer precursors or polyps in an ex vivo human colon model with a microwave colonoscopy algorithm. Nowadays, 22% of polyps go undetected with conventional colonoscopy, and the risk of cancer after a negative colonoscopy can be up to 7.9%. We developed a microwave colonoscopy device that consists of a cylindrical ring-shaped switchable microwave antenna array that can be attached to the tip of a conventional colonoscope as an accessory. The accessory is connected to an external unit that allows successive measurements of the colon and processes the measurements with a microwave imaging algorithm. An acoustic signal is generated when a polyp is detected. Fifteen ex vivo freshly excised human colons with cancer (n = 12) or polyps (n = 3) were examined with the microwave-assisted colonoscopy system simulating a real colonoscopy exploration. After the experiment, the dielectric properties of the specimens were measured with a coaxial probe and the samples underwent a pathology analysis. The results show that all the neoplasms were detected with a sensitivity of 100% and specificity of 87.4%.


Assuntos
Pólipos do Colo , Neoplasias Colorretais , Algoritmos , Pólipos do Colo/diagnóstico por imagem , Pólipos do Colo/patologia , Colonoscopia/métodos , Neoplasias Colorretais/diagnóstico por imagem , Humanos , Micro-Ondas
17.
Comput Intell Neurosci ; 2022: 9783113, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35795769

RESUMO

Purpose: To retrospectively evaluate the efficacy and safety of TACE combined with microwave ablation (MWA) and TACE combined with cryoablation (CRA) in the treatment of large hepatocellular carcinoma. Methods: A retrospective analysis was performed on 81 patients with large hepatocellular carcinoma (tumor diameter 5~8 cm cm) who received TACE combined with ablation in our hospital from February 2015 to February 2019. The study patients were divided into TACE combined with MWA group (T-MWA, n = 41) and TACE combined with CRA group (T-CRA, n = 40) according to the treatment plan. Overall survival (OS) and progress free survival (PFS) were compared between the two groups, and complications were observed. Survival curves for OS and PFS were constructed by the Kaplan-Meier method. Differences in overall survival were compared using the log-rank test. Results: There was no statistical difference in general conditions between the two groups of patients. The results showed that 30 (73.2%) patients in T-MWA group achieved objective response (OR) and 39 (95.1%) patients achieved disease control (DC), compared with 24 (60.0%) patients in T-CRA group who achieved objective response (OR) and 37 (92.5%) patients who achieved disease control (DC). The median OS was 19.2 months in the T-MWA group and 18.6 months in the T-CRA group (P=0.64). The median PFS was 9.3 months in the T-MWA group and 12.3 months in the T-CRA group (P=0.6). Univariate and multivariate analysis showed that portal vein tumor thrombus (PVTT), intrahepatic tumor diameter, and the number of tumor lesions were common prognostic factors for OS and PFS. In terms of surgery-related complications and adverse reactions, abdominal pain and gastrointestinal reactions were observed in 13 (31.7%) and 11(26.8%) cases in the T-MWA group, while we observed 4 (10.0%) and 2 (5.0%) cases in the T-CRA group, respectively. The difference between the two was statistically significant (P < 0.05). Conclusion: TACE combined with MWA and TACE combined with CRA were equally effective in the treatment of large hepatocellular carcinoma. TACE-CRA can effectively reduce the incidence of abdominal pain and gastrointestinal reactions in patients. However, compared with TACE-MWA, TACE-CRA is more likely to cause thrombocytopenia.


Assuntos
Carcinoma Hepatocelular , Quimioembolização Terapêutica , Criocirurgia , Neoplasias Hepáticas , Dor Abdominal/complicações , Dor Abdominal/cirurgia , Carcinoma Hepatocelular/patologia , Carcinoma Hepatocelular/cirurgia , Quimioembolização Terapêutica/efeitos adversos , Quimioembolização Terapêutica/métodos , Humanos , Neoplasias Hepáticas/patologia , Neoplasias Hepáticas/cirurgia , Micro-Ondas/efeitos adversos , Estudos Retrospectivos , Resultado do Tratamento
18.
Int J Mol Sci ; 23(13)2022 Jun 22.
Artigo em Inglês | MEDLINE | ID: mdl-35805954

RESUMO

With the rapidly increasing application of microwave technologies, the anxiety and speculation about microwave induced potential health hazards has been attracting more and more attention. In our daily life, people are exposed to complex environments with multi-frequency microwaves, especially L band and C band microwaves, which are commonly used in communications. In this study, we exposed rats to 1.5 GHz (L10), 4.3 GHz (C10) or multi-frequency (LC10) microwaves at an average power density of 10 mW/cm2. Both single and multi-frequency microwaves induced slight pathological changes in the thymus and spleen. Additionally, the white blood cells (WBCs) and lymphocytes in peripheral blood were decreased at 6 h and 7 d after exposure, suggesting immune suppressive responses were induced. Among lymphocytes, the B lymphocytes were increased while the T lymphocytes were decreased at 7 d after exposure in the C10 and LC10 groups, but not in the L10 group. Moreover, multi-frequency microwaves regulated the B and T lymphocytes more strongly than the C band microwave. The results of transcriptomics and proteomics showed that both single and multi-frequency microwaves regulated numerous genes associated with immune regulation and cellular metabolism in peripheral blood and in the spleen. However, multi-frequency microwaves altered the expression of many more genes and proteins. Moreover, multi-frequency microwaves down-regulated T lymphocytes' development, differentiation and activation-associated genes, while they up-regulated B lymphocytes' activation-related genes. In conclusion, multi-frequency microwaves of 1.5 GHz and 4.3 GHz produced immune suppressive responses via regulating immune regulation and cellular metabolism-associated genes. Our findings provide meaningful information for exploring potential mechanisms underlying multi-frequency induced immune suppression.


Assuntos
Micro-Ondas , Proteômica , Animais , Humanos , Imunidade , Linfócitos , Micro-Ondas/efeitos adversos , Ratos , Transcriptoma
19.
Food Chem ; 395: 133622, 2022 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-35802971

RESUMO

This study aims to produce oligosaccharides by microwave-assisted hydrothermal hydrolysis of agarose, which is a more environmentally friendly and green economical approach than acid or enzymatic hydrolysis. Under the optimized condition of 160 °C and 25 min, total liquefaction of agarose was achieved, the dominant products in the hydrolysate are agaro-oligosaccharides (AOs), with only a small portion of d-galactose and 5- hydroxymethylfurfural (5-HMF). This approach can produce even and odd number AOs simultaneously, which is due to the random hydrolysis of α-1,3 glycosidic linkage at first and subsequent hydrolysis of the ß-1,4 glycosidic linkage at the reducing end. The yield of AOs of a low degree of polymerization (DP) can reach about 57% of the theoretical maximum, while the total yield of AOs is over 90%. In conclusion, microwave-assisted hydrothermal hydrolysis is a way of producing oligosaccharides from agarose with extra-high efficiency and practical significance.


Assuntos
Micro-Ondas , Água , Hidrólise , Oligossacarídeos , Sefarose
20.
Molecules ; 27(14)2022 Jul 06.
Artigo em Inglês | MEDLINE | ID: mdl-35889212

RESUMO

In this work, as an equivocal proof of the potential of microwave irradiation in organic synthesis, a complex pyrazine-decorated benzotriazole derivative that is challenging to prepare under conventional conditions has been obtained upon microwave irradiation, thus efficiently improving the process and yields, dramatically decreasing the reaction times and resulting in an environmentally friendly synthetic procedure. In addition, this useful derivative could be applied in organic electronics, specifically in organic field-effect transistors (OFETs), exhibiting the highest electron mobilities reported to date for benzotriazole discrete molecules, of around 10-2 cm2V-1s-1.


Assuntos
Micro-Ondas , Semicondutores , Elétrons , Transistores Eletrônicos , Triazóis
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