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1.
Ned Tijdschr Tandheelkd ; 129(10): 385-389, 2022 Sep.
Artigo em Holandês | MEDLINE | ID: mdl-36074644

RESUMO

Squamous cell carcinoma in the head and neck area is rare in children and constitutes only 2% of malignancies. Between October 2019 and December 2020, 3 young, male patients presented at the Princess Máxima Centre for Paediatric Oncology with squamous cell carcinoma of the oral mucosa. All 3 had complaints of increasing, painful swelling in the oral cavity for weeks to months prior to the diagnosis. They had no risk factors for developing an oral malignancy and blank medical histories. In all 3 cases, there was a long delay preceding the diagnosis and the diagnosis was made at an advanced stage. Although rare, primary squamous cell carcinoma of the oral cavity can also occur in children.


Assuntos
Carcinoma de Células Escamosas , Neoplasias de Cabeça e Pescoço , Neoplasias Bucais , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/patologia , Criança , Humanos , Masculino , Mucosa Bucal/patologia , Neoplasias Bucais/diagnóstico , Estudos Retrospectivos , Carcinoma de Células Escamosas de Cabeça e Pescoço
2.
Appl Immunohistochem Mol Morphol ; 30(8): 566-572, 2022 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-35960013

RESUMO

This study aimed to analyze the immunohistochemical expression of H3K9ac and H4K12ac in oral leukoplakia (OL) and its association with cell proliferation marker Ki-67 and clinicopathologic data. Paraffin-embedded, formalin-fixed tissue samples from 50 OLs and 15 fragments of the normal oral mucosa (NOM) were submitted to immunohistochemical assay using the streptavidin-biotin-peroxidase method. Quantitative analysis of the antigen-antibody reaction was performed by obtaining integrated optical density (IOD) and the percentage of positive nuclei (PPN) with ImageJ software. OL samples presented higher PPN ( P =0.02) and lower IOD values ( P =0.007) for H4K12ac in comparison to NOM. The area under the receiver operating characteristic curve for PPN and IOD values of H4K12ac immunostaining were 0.70 ( P =0.02) and 0.73 ( P =0.007), respectively. No differences were found between OL and NOM for H3K9ac. Cell proliferation marker Ki-67 had a positive correlation with PPN ( P <0.0001) and IOD ( P =0.0007) for H3K9ac expression and with IOD values ( P =0.002) for H4K12ac expression. The present findings suggest that alterations in the acetylation pattern of H4K12 occur in the early stages of oral carcinogenesis and that both H3K9ac and H4K12ac might have a role in the regulation of epithelial cell proliferation of OL.


Assuntos
Antígeno Ki-67/metabolismo , Neoplasias Bucais , Proliferação de Células , Humanos , Leucoplasia Oral/patologia , Mucosa Bucal/patologia , Neoplasias Bucais/patologia
3.
Artigo em Inglês | MEDLINE | ID: mdl-36012046

RESUMO

We evaluated whether fluorescence intensity (FI) and its coefficient of variation (CV) can be used to diagnose squamous cell carcinoma (SCC) through IllumiScan®, an oral mucosa fluorescence visualisation (FV) device. Overall, 190 patients with oral mucosal lesions (OMLs; SCC, 59; non-SCC OMLs, 131) and 49 patients with normal oral mucosa (NOM) were enrolled between January 2019 and March 2021. The FI of the images was analysed using image analysis software. After establishing regions of interest for SCC, non-SCC, and NOM, the average FI, standard deviation (SD), and CV were compared. There was a significant difference in the average FI for all pairs of comparisons. The SD was not significantly different between the SCC and NOM groups (p = 0.07). The CV differed significantly for NOM (p < 0.001) and non-SCC groups (p < 0.001) relative to the SCC group but was not different between NOM and non-SCC groups (p = 0.15). Univariate analysis of SCC and non-SCC groups showed significant differences for all factors, except age. However, multivariate analysis showed a significant intergroup difference only in the CV (p = 0.038). Therefore, analysing the CV in FV images of OML may be useful for the diagnosis of oral cancer.


Assuntos
Carcinoma de Células Escamosas , Neoplasias Bucais , Lesões Pré-Cancerosas , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/patologia , Fluorescência , Humanos , Mucosa Bucal/patologia , Neoplasias Bucais/diagnóstico , Neoplasias Bucais/patologia , Lesões Pré-Cancerosas/diagnóstico
4.
Arch Oral Biol ; 142: 105525, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-36027639

RESUMO

OBJECTIVES: The aim of this study was to assess the MUC1 expression in the oral epithelium of normal, oral epithelial dysplasia (OED), oral squamous cell carcinoma (OSCC), and irradiated oral epithelium (IROE) and its association with smoking habits in non-smokers and smokers. DESIGN: Oral mucosal biopsies from controls, OED, OSCC, and IROE groups were obtained and categorized based on the smoking history as non-smokers, smoker I (25 pack-years), and smoker II (>25 pack-years). Immunohistochemical staining of MUC1 using human milk fat globule 1 (HMFG 1) antibody was performed, and the MUC1 score was calculated. The relation between MUC1 expression and clinicopathological findings was examined. RESULTS: MUC1 staining of superficial oral epithelial cells with mild MUC1 score was detected in all control samples. The MUC1 staining extended from superficial to basal cell layer of oral epithelium with the increase in MUC1 score from moderate to strong in OED, OSCC, and IROE, and the difference was significant (p < 0.004, p < 0.002 and p < 0.004, respectively) compared to controls. A positive association between smoking and MUC1 score was observed within groups (p < 0.05). CONCLUSION: The depolarization of MUC1 protein expression is associated with smoking habits in OED and OSCC. In the IROE, the radiation causes subcellular and molecular changes, observed as altered MUC1 expression and accelerated by smoking, furthermore, complicating the oral mucosal adaptation and progress to radiation-induced lesions as a delayed effect.


Assuntos
Carcinoma de Células Escamosas , Mucina-1 , Fumar , Carcinoma de Células Escamosas/genética , Carcinoma de Células Escamosas/patologia , Epitélio/metabolismo , Epitélio/patologia , Epitélio/efeitos da radiação , Humanos , Mucosa Bucal/metabolismo , Mucosa Bucal/patologia , Mucosa Bucal/efeitos da radiação , Neoplasias Bucais/genética , Neoplasias Bucais/patologia , Mucina-1/metabolismo , Fumar/efeitos adversos
5.
Photodiagnosis Photodyn Ther ; 39: 103019, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35850459

RESUMO

Ulcers in the oral mucosa is a relatively common, although challenging, entity in oral medicine, as it can arise due to a wide range of traumatic, infective, autoimmune, and neoplastic disorders. Although histopathology of lesional and peri­lesional tissues remains the gold standard for persistent oral breaching, optical coherence tomography (OCT) has been recently suggested as a potential ally to enhance the early or non-invasive diagnosis of likely causation. The aim of the present study was to provide an in-vivo OCT analysis and description from a sample of 70 patients affected by traumatic or neoplastic-related ulcers, located on the buccal mucosa, tongue or gingiva, and compare the OCT data with those of 20 patients with healthy oral mucosa. OCT dynamic scans revealed clear distinction of epithelial layer (EP), lamina propria (LP) of healthy buccal mucosa, gingiva, and tongue as well as allowing observation of the keratin layer in gingiva, and the subepithelial vascularization of each site. Traumatic lesions had an EP of reduced in thickness, with an irregular, if not disrupted surface. Interestingly, LP seemed to preserve its reflectiveness and vascularization only in the traumatic lesions. Among neoplastic lesions, regardless their site of onset, both EP integrity/homogeneity, and LP reflectiveness/vascularization were lost and unrecognizable when compared to their healthy counterparts. OCT scanning allowed some differentiation between traumatic and malignant ulcers and thus may a useful and non-invasive means of determining the need and/or urgency of histopathological examination of oral lesions.


Assuntos
Úlceras Orais , Fotoquimioterapia , Humanos , Mucosa Bucal/diagnóstico por imagem , Mucosa Bucal/patologia , Úlceras Orais/patologia , Fotoquimioterapia/métodos , Tomografia de Coerência Óptica/métodos , Úlcera/patologia
6.
Artigo em Inglês | MEDLINE | ID: mdl-35897373

RESUMO

Background: The objective was to reveal the most typical changes in oral mucosa in HCV patients and compare them with those in HCV negative patients. Methods: The study involved 96 HCV patients and 100 patients without HCV who applied to a dental clinic. The content of cytokines IL-2, IL-4, IL-10 and ɤ-INF in the oral fluid was determined by ELISA. Buccal mucosa and gums biopsies passed histological examination. An immunohistochemical study of mucous membrane biopsies was performed using monoclonal mouse antibodies to CD3+ and CD20+. Results: The HCV patients group included 96 (63.5% males), and the non-HCV group included 100 subjects (62.0% males) with lesions of the oral mucous membrane. The lesions of lips and oral mucosa were more frequent in HCV than in the non-HCV group-e.g., erosion (13.5% vs. 1%), cracks in the mouth corners (42.7% vs. 0%), changes in the oral mucosa surface (89.6% vs. 3.0%), hemorrhages (78.1% vs. 0%), etc. The pro-inflammatory IL-2 level was higher and anti-inflammatory IL-4 level was lower in HCV patients compared with those in the non-HCV group. Conclusions: Morphological changes developed in the microvasculature both worsen the tissue trophism and accelerate the healing with differentiation into coarse-fibrous connective tissue. Immunohistochemical findings indicated a decrease in local humoral immune response.


Assuntos
Hepatite C , Mucosa Bucal , Estudos Transversais , Citocinas , Feminino , Hepatite C/patologia , Humanos , Interleucina-2 , Interleucina-4 , Masculino , Mucosa Bucal/patologia
7.
Ned Tijdschr Tandheelkd ; 129(7-8): 329-336, 2022 Jul.
Artigo em Holandês | MEDLINE | ID: mdl-35833281

RESUMO

Allogeneic stem cell transplantation can cause chronic graft versus host disease (cGVHD). A number of patients manifest cGVHD in and around the mouth. It can present itself as clinically as mucosal lesions and/or salivary gland dysfunction and/or sclerotic changes. Cheeks and tongue are most commonly affected, but the palate, gingiva and lips can also be impacted. Oral cGVHD is associated with mucosal sensitivity, pain, (severe) oral dryness, altered taste, restricted mouth opening and difficulty swallowing, all of which may contribute to a significant decrease of the patient's quality of life. Patients also run an increased risk of developing squamous cell carcinoma of the oral mucosa. The diagnosis of cGVHD is almost always based on the patient's medical history and clinical picture. Treatment of symptoms is based on the patient's problem(s). Dental professionals can provide patients with supportive preventive care aimed at reducing symptoms and preventing further deterioration of oral health.


Assuntos
Doença Enxerto-Hospedeiro , Transplante de Células-Tronco Hematopoéticas , Doenças da Boca , Doença Crônica , Doença Enxerto-Hospedeiro/tratamento farmacológico , Doença Enxerto-Hospedeiro/etiologia , Doença Enxerto-Hospedeiro/patologia , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Humanos , Doenças da Boca/diagnóstico , Doenças da Boca/etiologia , Doenças da Boca/terapia , Mucosa Bucal/patologia , Qualidade de Vida
8.
Ned Tijdschr Tandheelkd ; 129(7-8): 338-339, 2022 Jul.
Artigo em Holandês | MEDLINE | ID: mdl-35833282

RESUMO

A 25-year-old man presented with a milky-white abnormality of the buccal mucosa on either cheek. Clinical examination revealed underlying leukoedema. Leukoedema is a clinical diagnosis confirmed when the white appearance of the buccal mucosa virtually disappears when it is stretched. The abnormality falls within the normal variation of the buccal mucosa and a biopsy and/or treatment are not necessary.


Assuntos
Mucosa Bucal , Adulto , Bochecha , Humanos , Masculino , Mucosa Bucal/patologia
9.
Pan Afr Med J ; 41: 336, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35865836

RESUMO

Lipoma is a common tumor of soft tissue with rare occurrence in oral cavity accounting for only 1-4% of benign oral tumours. It may be noticed only during routine dental examinations. Most of them rarely cause pain, resulting in delay to seek treatment. Lipoma of the oral cavity may occur in any region. The buccal mucosa, tongue, and floor of the mouth are among the common locations. A case of large intraoral lipoma occurring in mental region in a 60-year-old female patient is reported. It was treated surgically under local anesthesia, and 6 month follow up showed excellent healing without any recurrence.


Assuntos
Lipoma , Neoplasias Bucais , Anestesia Local , Feminino , Humanos , Lipoma/diagnóstico , Lipoma/patologia , Lipoma/cirurgia , Pessoa de Meia-Idade , Mucosa Bucal/patologia , Neoplasias Bucais/diagnóstico , Neoplasias Bucais/patologia , Neoplasias Bucais/cirurgia , Cicatrização
10.
Oral Oncol ; 132: 105995, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-35759858

RESUMO

BACKGROUND: Oral squamous cell carcinoma (OSCC) of the gingiva represents less than 6% of intraoral carcinomas. CASE REPORT: A 51-year-old male patient presented with a history of a symptomatic red spot with periods of remission and recurrence in the mandibular gingiva. On clinical examination red and white areas were observed in the gingiva, particularly around the left lower molars. Diagnosis of gingival lichen planus was suspected and topical corticosteroids was prescribed. A good clinical response was observed with reduction of symptom. The patient remained in regular follow-up and after 9 months, the lesion suddenly changed, became ulcerated and diagnosis of OSCC was established. CONCLUSION: The clinical manifestation of OSCC can eventually mimic other even more common lesions of the oral mucosa, highlighting the importance of considering OSCC as differential diagnosis of any unexplained and persistent lesion in the oral cavity.


Assuntos
Carcinoma de Células Escamosas , Líquen Plano Bucal , Líquen Plano , Neoplasias Bucais , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/patologia , Gengiva/patologia , Humanos , Líquen Plano Bucal/patologia , Masculino , Pessoa de Meia-Idade , Mucosa Bucal/patologia , Neoplasias Bucais/diagnóstico , Neoplasias Bucais/patologia
11.
Gen Dent ; 70(4): 44-47, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35749246

RESUMO

A solitary fibrous tumor (SFT) is an uncommon mesenchymal tumor characterized by spindle cell proliferation that rarely affects the oral cavity. The clinical and histopathologic features of an oral SFT are described for the benefit of dental practitioners who may encounter one of these rare cases. A 25-year-old man presented with a slow-growing swelling in the left buccal mucosa. A painless, exophytic, and well-circumscribed submucosal lesion was detected, and an excisional biopsy was performed. The biopsy specimen was submitted for histologic and immunohistochemical staining and subsequent microscopic analysis. The histopathologic examination revealed variable cellularity areas that included spindle- and star-shaped cell proliferation. These cells were immersed in a collagenized stroma containing branching vessels with a staghorn arrangement. According to immunohistochemical analysis, the tumor was characterized by STAT6, CD34, ß-catenin, and Bcl-2 expression. Diagnosis of oral SFTs is challenging given that their microscopic characteristics can mimic those of malignant mesenchymal neoplasms.


Assuntos
Mucosa Bucal , Tumores Fibrosos Solitários , Adulto , Biomarcadores Tumorais/análise , Odontólogos , Humanos , Imuno-Histoquímica , Masculino , Mucosa Bucal/patologia , Papel Profissional , Tumores Fibrosos Solitários/diagnóstico , Tumores Fibrosos Solitários/metabolismo , Tumores Fibrosos Solitários/cirurgia
12.
Braz Dent J ; 33(3): 67-73, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35766718

RESUMO

The clinicopathological features that precisely characterize oral lichen planus (OLP) and oral lichenoid lesions (OLL) still represent a challenge. The aim of the present study was to analyze, from an oral pathologist perspective, the clinical features from OLP and OLL. Specimens fullfilling the histological criteria for OLP and OLL, and also compatible with OLP (OLP-C), were selected and clinical information was retrieved from the laboratory forms. The final sample was composed by 221 cases, including 119 OLP (53.8%), 65 OLP-C (29.4%) and 37 OLL (16.7%). Females were more affected in the three groups, but the number of males was higher in OLL. Mean age was lower in OLP (52.3 years) in comparison with OLL (57.9 years) (p=0.020). Buccal mucosa and tongue involvement was more frequent in OLP; gingival involvement was uncommon in OLL. The reticular pattern was more frequently found in OLP, while the association of reticular and atrophic/erosive/ulcerated patterns was more common in OLP-C and OLL (p=0.025). In conclusion, gender and mean age of the patients, and anatomical location and clinical manifestation of OLL are different from OLP, and could help to better characterize this group of conditions. Specimens diagnosed as OLP-C showed clinical parameters close to OLP.


Assuntos
Líquen Plano Bucal , Erupções Liquenoides , Neoplasias Bucais , Feminino , Humanos , Erupções Liquenoides/diagnóstico , Erupções Liquenoides/patologia , Masculino , Pessoa de Meia-Idade , Mucosa Bucal/patologia , Neoplasias Bucais/patologia , Patologistas
13.
Int J Mol Sci ; 23(11)2022 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-35682789

RESUMO

Oral submucous fibrosis (OSF) belongs to a group of potentially malignant disorders that are characterized by the progressive fibrosis of the lining mucosa as well as an increasing loss of tissue mobility [...].


Assuntos
Neoplasias Bucais , Fibrose Oral Submucosa , Fibrose , Humanos , Mucosa Bucal/patologia , Neoplasias Bucais/tratamento farmacológico , Neoplasias Bucais/etiologia , Neoplasias Bucais/patologia , Fibrose Oral Submucosa/tratamento farmacológico , Fibrose Oral Submucosa/etiologia , Fibrose Oral Submucosa/patologia
14.
Ned Tijdschr Tandheelkd ; 129(6): 289-292, 2022 Jun.
Artigo em Holandês | MEDLINE | ID: mdl-35670462

RESUMO

A 55-year-old woman was seen at an oral and maxillofacial surgery department because of a large oral swelling and complaints about difficulty eating, nasal speech and fatigue. She had full dentures in her upper jaw. Intraorally, a pain-free, pedunculated, combined solid-elastic and bone-hard tumour was found in the left maxillary tubercle region. A large, fibroepithelial polyp was diagnosed based on clinical and histopathological findings. Six weeks post-operatively, the complaints had disappeared. Chronic irritation of the oral mucosa can result in an oral fibroepithelial polyp that can be distinguished from peripheral ossifying fibroma or giant cell fibroma after histopathological examination. Such a polyp can grow to a large size if the source of irritation is not removed.


Assuntos
Pólipos , Neoplasias Cutâneas , Feminino , Humanos , Pessoa de Meia-Idade , Mucosa Bucal/patologia , Faringe/patologia , Pólipos/diagnóstico , Pólipos/patologia , Pólipos/cirurgia
15.
Gulf J Oncolog ; 1(39): 39-46, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35695345

RESUMO

INTRODUCTION OR BACKGROUND: This prospective analysis of patients with squamous cell carcinoma of the buccal mucosa, aimed to analyze the correlation between depth of invasion (DOI) observed in pre-operative imaging and the post-operative histopathological findings, and to assess the predictive value of magnetic resonance imaging. PATIENTS AND METHODS: All cases of squamous cell carcinoma of buccal mucosa, planned for primary surgery followed by adjuvant treatment, between June 2017 to December 2019 were included in the analysis. All patients were taken up for imaging using 3 Tesla MR imaging system and subsequently had undergone surgery. The imaging parameters and the histopathological data were analyzed statistically. RESULTS: Of the 45 patients analyzed, 86.7% were males. Mean age at presentation was 60.62 years. All had squamous histology, with 62.2% being moderately differentiated. 68.9% were T4, 46.7%, N0 and 31.3%, N3. Six node positive patients showed perinodal invasion on histopathology. The mean DOI observed in MRI was 16.54mm, while that in histopathological evaluation was 20.24mm. DISCUSSION: A significant correlation was observed between imaging and histopathology values in terms of the DOI, with Spearman's Rho correlation coefficient showing 0.693 (p-<0.001). Nodal positivity observed in the imaging and the histopathological findings showed only a moderate correlation of 0.409, with p values of 0.005 (Pearson, Spearman's rho) and 0.007 (Kendall's tau_b). A significant correlation was not observed between nodal involvement and DOI assessed by imaging nor with histopathological assessment. With a cut-off value of 5mm as imaging DOI, the positive predictive value (PPV) for nodal positivity was only 37.14%, while the negative predictive value (NPV) was 95%. The sensitivity was 96.3%, and specificity 30.16%. When the cutoff was raised to 10mm, the values for PPV, NPV, sensitivity and specificity were, 44.07%, 61.29%, 68.42% and 36.54%. CONCLUSION: Despite being a histopathological parameter, accurate or near accurate evaluation of DOI can be achieved using MR imaging. Our study convincingly shows that magnetic resonance imaging can be considered the imaging of choice for the evaluation of depth of invasion of the tumour in squamous cell carcinoma of the buccal mucosa, though it fails to show any predictive value for nodal involvement.


Assuntos
Carcinoma de Células Escamosas , Mucosa Bucal , Carcinoma de Células Escamosas/patologia , Feminino , Humanos , Metástase Linfática , Imageamento por Ressonância Magnética/métodos , Masculino , Mucosa Bucal/patologia , Estadiamento de Neoplasias , Estudos Retrospectivos
16.
Arch. pediatr. Urug ; 93(1): e306, jun. 2022. ilus
Artigo em Espanhol | LILACS, BNUY, UY-BNMED | ID: biblio-1383647

RESUMO

La hiperplasia de glándulas sebáceas es un hallazgo benigno y transitorio, común en el período neonatal. Secundariamente al estímulo hormonal androgénico se produce un hipercrecimiento de las glándulas, con mayor frecuencia en nariz y mejillas, donde existen en mayor densidad. La hiperplasia de glándulas en una localización ectópica, llamada gránulos de Fordyce (GF), es excepcional en el período neonatal. Se han reportado en aproximadamente 1% de los recién nacidos, y con frecuencia se localizan en la mucosa oral. Los GF se describen como lesiones papulares de aspecto vesiculoso blanco amarillentas de 1-3 mm2, que podrían confundir al neonatólogo o al pediatra con entidades infecciosas, dando lugar a pruebas invasivas y tratamientos innecesarios. Se describen tres casos clínicos de neonatos con diagnóstico de hiperplasia sebácea ectópica localizada en mucosa oral, con el objetivo de revisar la etiología, las características clínicas, los diagnósticos diferenciales y la evolución de esta entidad benigna. Conclusiones: la hiperplasia sebácea ectópica en mucosa oral de neonatos es un hallazgo benigno autolimitado que se presenta con baja frecuencia. El reconocimiento clínico de esta entidad es importante para evitar diagnósticos incorrectos y tratamientos innecesarios.


Sebaceous gland hyperplasia is a common transient and benign finding in neonates. After androgenic hormonal stimulation, there is a gland overgrowth mainly in the nose and cheeks where there is a greater density of glands. Ectopic sebaceous gland hyperplasia, called Fordyce's Granules (FG), is exceptional in neonates and it is reported in approximately 1% of newborns and frequently located in the oral mucosa. FGs are described as 1-3mm2 yellowish-white papular and vesicular lesions. Neonatologists or pediatricians may confuse these clinical features with infectious diseases, leading to invasive tests and unnecessary treatment. We describe three clinical cases of neonates with diagnosis of ectopic sebaceous gland hyperplasia located in the oral mucosa, with the aim of reviewing the etiology, clinical characteristics, differential diagnoses and evolution of this benign entity. Conclusions: ectopic sebaceous gland hyperplasia of the lips is a self-limited benign finding occurring infrequently in newborns. The clinical recognition of this entity is important to avoid inaccurate diagnoses or unnecessary treatment.


A hiperplasia das glândulas sebáceas é um achado benigno e transitório comum nos neonatos. Secundário ao estímulo hormonal androgênico, há um hipercrescimento das glândulas com mais frequência no nariz e nas bochechas onde há uma maior densidade das glândulas. A hiperplasia das glândulas num local ectópico, chamado Fordyce Granules (FG), é excepcional no período neonatal, e ela é relatada em aproximadamente 1% dos recém-nascidos e muitas vezes está localizada na mucosa oral. Os FGs são descritos como lesões vesiculares brancas amareladas de 1-3mm2, o que poderia confundir o neonatologista ou pediatra com entidades infecciosas, levando a testes invasivos e tratamentos desnecessários. Descrevemos três relatos clínicos de recém-nascidos com diagnóstico de hiperplasia sebácea ectópica localizada na mucosa oral, com o objetivo de rever a etiologia, características clínicas, diagnósticos diferenciais e evolução desta entidade benigna. Conclusões: hiperplasia sebácea ectópica na mucosa oral de recém-nascidos é um achado benigno autolimitante que ocorre com baixa frequência. O reconhecimento clínico desta entidade é importante para evitar diagnósticos incorretos e tratamentos desnecessários.


Assuntos
Humanos , Masculino , Recém-Nascido , Infecções Estreptocócicas/diagnóstico , Streptococcus agalactiae , Herpes Simples/diagnóstico , Hiperplasia/diagnóstico , Mucosa Bucal/patologia , Diagnóstico Diferencial
17.
Biomed Res Int ; 2022: 8100352, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35692588

RESUMO

Objectives: This study is aimed at identifying and determining the distribution of isolated Candida species in patients with dysplastic and nondysplastic oral lichen planus (OLP) lesions in comparison with those of healthy controls. Material and Methods. This study includes patients with OLP, aged (more than 18 years old), who have had informed consent. Samples of the oral, tongue, and buccal mucus by rubbing with a sterile swab and sterilely next to the lamp flame. Demographic information was obtained using patient records to determine the species of Candida in both groups, and two tests of fertile tube production by Candida albicans and dye production in the dye medium were used. A biopsy from OLP lesions has been taken from each patient after swab sampling and was sent to the pathology department for further histopathological analysis. In the end p value, less than 0/05 was considered significant. Result: In this study, 40 lichen planus patients were compared with 32 control patients. The female/male ratio in OLP and healthy groups was 22/18 and 17/15, respectively. Among the OLP patients, 23 cases (56%) were dysplastic, and the other 17 (44%) patients were nondysplastic. The mean (±standard deviation (SD)) age of patients was 48.83 (±9.34) years, and the mean age of the control group was 40.21 (±10.32). There were no significant differences based on age (p > 0.05). The highest frequency was related to tongue in both groups (22 (55%)) and buccal mucosa was the least common. There was a significant relationship between the location of the lesion and OLP (p = 0.05). 18 (45%) were erosive, and 22 (55%) were nonerosive. However, no significant difference was observed between erosive and nonerosive types in the OLP group (p = 0/07). Regarding the type of Candida, all cases in the patient's group were related to Candida albicans [40 (100%)], and the correlation was not found in this regard (p > 0/05). About colony count, the mean for the case and control groups was 26.68 and 23.25, respectively. Also, no significant relationship was found between colony count and groups in this study (p = 0.3). There was no significant difference between gender and dysplastic or nondysplastic (p > 0.05). Conclusion: According to the statistical studies performed in this study, the presence of Candida in patients with dysplastic and nondysplastic lichen planus is not significantly different, and this rate is not higher than healthy individuals and in cases where the results are positive. The predominant species of Candida is the Candida albicans. In this study, the highest frequency was related to tongue in both groups. There was only a significant relationship between the location of the lesion and OLP.


Assuntos
Líquen Plano Bucal , Líquen Plano , Adolescente , Candida , Candida albicans , Feminino , Humanos , Hiperplasia/patologia , Líquen Plano/patologia , Líquen Plano Bucal/patologia , Masculino , Mucosa Bucal/patologia
19.
Med. oral patol. oral cir. bucal (Internet) ; 27(3): e230–e237, may. 2022. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-204665

RESUMO

Background: The diagnosis of oral melanotic lesions is, more often than not, challenging in the clinical practice due to the fact that there are several reasons which may cause an increase in pigmentation on localized or generalized areas. Among these, medication stands out. Material and Methods: In this work, we have carried out a review in the reference pharma database: Micromedex® followed by a review of the scientific published literature to analyse coincidences and possible discrepancies. Results: Our findings show that there are several prescription drugs that can cause pigmented lesions in the oral mucosa. This must be known by clinicians in order to properly diagnose pigmented lesions. We have identified a set of 21 medicaments which cause these lesions, some of which are used frequently in the clinic, such as Metronidazole, Amitriptyline, conjugated oestrogens and Chlorhexidine gluconate. We also found discrepancies with the data published in specialized literature, some of which wasn’t reflected in the Summary of Product Characteristics. Conclusions: Our work highlights the importance of the proper communication of adverse drug reactions (ADR) by health professionals in order to provide thorough and accurate information and diagnosis.(AU)


Assuntos
Humanos , Mucosa Bucal/patologia , Úlceras Orais , Pigmentação
20.
Actas dermo-sifiliogr. (Ed. impr.) ; 113(5): 459-466, Mayo 2022. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-206487

RESUMO

Antecedentes y objetivo: La psoriasis es una enfermedad con una gran implicación sistémica en la que se ha descrito una mayor prevalencia de alteraciones de la mucosa oral. El objetivo del estudio fue determinar la prevalencia de alteraciones orales en pacientes con psoriasis y su asociación con las características clínicas y epidemiológicas de la enfermedad. Material y métodos: Se realizó un estudio transversal, incluyendo pacientes con psoriasis y voluntarios sanos entre diciembre de 2019 y febrero de 2020. Se recogieron datos biométricos, comorbilidades asociadas y alteraciones orales detectadas en la exploración física. Además, en los pacientes con psoriasis se registraron las características clínicas de la enfermedad. Resultados: Se incluyeron 100 pacientes con psoriasis y 100 controles. Los pacientes con psoriasis presentaron una mayor prevalencia de alteraciones de la mucosa oral respecto al grupo control (74% frente a 46%, p<0,001), destacando una mayor prevalencia de lengua fisurada (LF) (39% frente a 16%, p<0,001) y periodontitis (28% frente a 16%, p=0,04). La lengua geográfica resultó poco frecuente en ambos grupos (4% frente a 2%, p=0,68). Dentro del grupo con psoriasis, los pacientes con LF presentaron mayor prevalencia de enfermedad cardiovascular (23,1% frente a 4,9%), diabetes mellitus (28,2% frente a 8,2%) y artritis psoriásica (15,4% frente a 1,6%) que aquellos sin LF. Los pacientes con periodontitis presentaron también mayor frecuencia de enfermedad cardiovascular (28,6% frente a 5,6%). La forma, la localización y el tiempo de evolución de la psoriasis no se relacionaron con más alteraciones orales. Sin embargo, los pacientes con alteraciones orales presentaron valores medios de la escala PASI (índice de severidad del área de psoriasis) más elevados (3,9 frente a 2,4, p=0,05). Los pacientes con LF presentaron un PASI más elevado que aquellos sin LF (4,7 frente a 2,7, p=0,03) (AU)


Background and objective: Psoriasis is a multisystem disease associated with an increased prevalence of oral lesions. The aim of this study was to determine the prevalence of oral lesions in patients with psoriasis and examine associations with clinical and patient characteristics. Material and methods: We conducted a cross-sectional study of patients with psoriasis and healthy controls seen between December 2019 and February 2020. We recorded biometric data, comorbidities associated with psoriasis, oral examination findings, and clinical characteristics of psoriasis. Results: We studied 100 patients with psoriasis and 100 controls. Oral lesions were more common in the psoriasis group (74% vs 46%, P<.001). The most common lesions were fissured tongue (39% vs 16%, P<.001) and periodontitis (28% vs 16%, P=.04). Geographic tongue was uncommon in both the study and the control group (4% vs 2%, P=.68). In the psoriasis group, patients with fissured tongue had a higher prevalence of cardiovascular disease (23.1% vs 4.9%), diabetes mellitus (28.2% vs 8.2%), and psoriatic arthritis (15.4% vs 1.6%) than those without this condition. Periodontitis was also associated with a higher prevalence of cardiovascular disease (28.6% vs 5.6%). Type of psoriasis, location, and time since onset were not significantly associated with oral lesions. Patients with oral lesions, however, had more severe disease (Psoriasis Area Severity Index [PASI], 3.9 vs 2.4; P=.05). Mean PASI was also higher in patients with fissured tongue (4.7 vs. 2.7, P=.03) and periodontitis (5.1 vs. 2.9, P=.04). (AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Psoríase/complicações , Psoríase/epidemiologia , Mucosa Bucal/patologia , Doenças da Boca/epidemiologia , Doenças da Boca/etiologia , Estudos de Casos e Controles , Estudos Transversais , Prevalência
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