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1.
Parasitol Int ; 86: 102481, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34688883

RESUMO

Dirofilariasis is an emerging zoonosis caused by nematodes of the genus Dirofilaria, most often D. repens and D. immitis. The main final hosts and reservoirs of pathogens are dogs. The intermediate hosts and vectors of infection are female mosquitoes (Culicidae). Human is an accidental host in which the parasite does not usually mature. Over the past 20 years, the range of Dirofilaria spp. in Europe has expanded. We present an unusual case of multifocal dirofilariasis of mixed subcutaneous-ocular course caused by D. repens in a 52-year-old Polish patient who was probably infected in Spain or Croatia, where she stayed one year before the onset of symptoms. Surgical removal of the nematodes followed by treatment with Ivermectin in a single dose of 1200 µg and Doxycycline 200 mg daily for 7 days resulted in complete recovery. We believe that all cases of human dirofilariasis, especially in countries where the disease is not frequent at present, should be registered for epidemiological purposes. Moreover, due to the widening of the range of D. repens and D. immitis occurrence and the possibility of atypical courses of infection with both nematodes, diagnostics should include the species identification of the parasite.


Assuntos
Dirofilaria repens/isolamento & purificação , Dirofilariose/diagnóstico , Oftalmopatias/diagnóstico , Dermatopatias/diagnóstico , Animais , Antiparasitários/administração & dosagem , Croácia , Dirofilariose/tratamento farmacológico , Dirofilariose/parasitologia , Dirofilariose/cirurgia , Doxiciclina/administração & dosagem , Oftalmopatias/tratamento farmacológico , Oftalmopatias/parasitologia , Oftalmopatias/cirurgia , Feminino , Humanos , Ivermectina/administração & dosagem , Pessoa de Meia-Idade , Polônia , Dermatopatias/tratamento farmacológico , Dermatopatias/parasitologia , Dermatopatias/cirurgia , Espanha , Viagem , Resultado do Tratamento
2.
Zhonghua Yan Ke Za Zhi ; 57(11): 871-875, 2021 Nov 11.
Artigo em Chinês | MEDLINE | ID: mdl-34743475

RESUMO

Coronaviruses are RNA viruses. We should be alerted from the outbreak of the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003, the discovery of the human coronavirus NL63 (HCoV-NL63) in 2004 and the pneumonia outbreak caused by the novel coronavirus in 2019 (2019-nCoV). Coronaviruses can adhere to mucous membranes of the eye, nose, mouth, respiratory tract and digestive tract through various media, which leads to inflammatory reaction, pulmonary fibrosis, kidney failure and death in severe cases. As an exposed organ, the eye can also be infected. With the progress of molecular technology and the in-depth research of coronaviruses, there have been seven known coronaviruses that can infect humans, among which HCoV-NL63, SARS-CoV and 2019-nCoV can cause eye diseases. This article summarizes and analyzes the latest research results at home and abroad concerning the structural characteristics, transmission routes, ocular pathogenic characteristics and treatment of HCoV-NL63, SARS-CoV and 2019-nCoV, in order to provide reference for clinical diagnosis and treatment. (Chin J Ophthalmol, 2021, 57: 871-875).


Assuntos
COVID-19 , Coronavirus Humano NL63 , Oftalmopatias , Humanos , SARS-CoV-2
4.
Ital J Pediatr ; 47(1): 217, 2021 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-34736495

RESUMO

BACKGROUND: We investigated the volume and the characteristics of pediatric eye emergency department (PEED) consultations performed at our tertiary eye center during the early months of the COVID-19 pandemic and we compared them to those carried out in the same time interval of the previous three years. METHODS: Ophthalmic emergency examinations of patients aged ≤18 years old and done during the national COVID-19 lockdown (March 9th, 2020 - May 3rd, 2020) and in the corresponding date range of the previous three years (2017, 2018, and 2019) have been considered and reviewed. The following features were retrieved and analyzed: age, gender, duration and type of accused symptoms, traumatic etiology, and the discharge diagnosis. RESULTS: 136, 133, and 154 PEED visits have been performed respectively in 2017, 2018, and 2019, while 29 patients presented in 2020. Therefore, the volume of PEED activity decreased by 79.4% (p < 0.0001). Demographical and clinical characteristics were comparable to those of the pre-COVID period. Despite the absolute reduction in the number of traumas, urgent conditions increased significantly from 30.7 to 50.7% (p = 0.024). CONCLUSIONS: PEED activity decreased consistently after the onset of the pandemic and it was mainly attended by those children whose conditions required prompt assistance, reducing the number of patients diagnosed with milder pathologies. At the end of the emergency, better use of PEED could avoid overcrowding and minimize waste, allowing resource optimization for the management of urgent cases.


Assuntos
COVID-19/epidemiologia , Serviço Hospitalar de Emergência/estatística & dados numéricos , Oftalmopatias/epidemiologia , Fatores Etários , COVID-19/prevenção & controle , COVID-19/transmissão , Criança , Pré-Escolar , Controle de Doenças Transmissíveis , Emergências , Oftalmopatias/diagnóstico , Oftalmopatias/terapia , Utilização de Instalações e Serviços , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Estudos Retrospectivos
5.
Middle East Afr J Ophthalmol ; 28(2): 123-128, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34759671

RESUMO

PURPOSE: This study aims to assess knowledge, attitude, and practice (KAP) around diabetic eye disease in patients with diabetes mellitus (DM) attending primary health-care centers (PHCCs) in Jazan region, Saudi Arabia. METHODS: All diabetic patients attending eight PHCCs in Jazan region between December 2018 and December 2019 were invited to participate in this cross-sectional study. Face-to-face interviews were held to gather responses to a validated 20-item questionnaire. RESULTS: In total, 293 patients aged 9-90 years (mean 50 years, standard deviation 14 years) agreed to participate, including 189 (64.5%) females and 104 (35.5%) males. Most (n = 251; 85.7%) had type 2 DM, the remainder (42; 14.3%) having type 1 DM. The mean duration of DM was 8.2 ± 6.4 years. Eye complications were self-reported by 114 (38.9%) participants. More than one-third (36.2%) of the participants had never undergone an eye examination. Less than one-third of participants (29% and 28% respectively) had an excellent level of knowledge or practice about diabetic eye disease, and only 12% demonstrated very positive attitude. KAP levels were independently predicted by patients' age, gender, and eye complication status. CONCLUSION: KAP relating to eye disease and eye care among Saudi patients with DM were less than desired. Rigorous efforts are required to raise awareness of eye complications among diabetic patients.


Assuntos
Diabetes Mellitus Tipo 2 , Oftalmopatias , Estudos Transversais , Oftalmopatias/epidemiologia , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Masculino , Arábia Saudita/epidemiologia
6.
Lakartidningen ; 1182021 10 22.
Artigo em Sueco | MEDLINE | ID: mdl-34676526

RESUMO

A retrospective study was performed at three primary care centers, between 1 July 2019 and 31 January 2020. During that period, 200 patients were assessed for eye/vision problems. Demographic data as well as how they were examined, diagnosed and the treatment that was given to them were registered. The most common complaint was eyelid-related conditions (n=60). External inspection of the anterior segment of the eye was the most common investigation (186 patients), whereas visual acuity was meaured in only 19 instances. Infectious conjunctivitis was the most common diagnosis (n=54) and 87 % of those patients were given topical antibiotics. The majority of the patients (60%) were diagnosed and treated at the primary care unit. 72 (36%) were referred to specialized eye care.  We hope that the results of this study will contribute to developing standardized routines and specified equipment demands in primary health care for patients seeking help with ophthalmological problems.


Assuntos
Conjuntivite , Oftalmopatias , Oftalmopatias/diagnóstico , Oftalmopatias/epidemiologia , Oftalmopatias/terapia , Humanos , Atenção Primária à Saúde , Estudos Retrospectivos , Acuidade Visual
7.
Vestn Oftalmol ; 137(5. Vyp. 2): 181-188, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34669326

RESUMO

PURPOSE: To evaluate the structure of vitreous body in asteroid hyalosis by low vacuum scanning electron microscopy. MATERIAL AND METHODS: The material of the study was samples of the vitreous body obtained from 7 patients aged from 62 to 72 years with vitreomacular traction syndrome during vitrectomy. In all cases, clinical manifestations of asteroid hyalosis (the presence of multiple point-like echo-positive inclusions) were identified during the preoperative examination. Samples for scanning electron microscopy and chemical microanalysis were prepared without using fixation elements, total dehydration, staining or centrifugation, and according to the so-called principle of bougienage, which consists in partial separation of fractions of the gel-like tissue with a stream of saline. RESULTS: The conducted examinations made it possible to identify various types of local accumulations of mineral elements in the vitreous body in asteroid hyalosis - called asteroid bodies - that is, multiple complex rounded formations consisting of needle-shaped crystals of a radial fibrous structure. CONCLUSION: The developed algorithm, which includes intraoperative sampling of the vitreous body in conditions of its minimal hydration and a special technique for preparing samples for scanning electron microscopy and chemical microanalysis, provides the capability for the in vivo assessment of morphological changes in hyaloid elements of the vitreous body. With that, asteroid bodies can be considered as markers of the vitreous structures that are difficult to visualize.


Assuntos
Oftalmopatias , Doenças Retinianas , Oftalmopatias/diagnóstico , Oftalmopatias/cirurgia , Humanos , Microscopia Eletrônica de Varredura , Transtornos da Visão , Vitrectomia , Corpo Vítreo
8.
Przegl Epidemiol ; 75(2): 175-183, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34696554

RESUMO

We describe the case of a HIV-infected patient, in whom a secondary syphilis with skin lesions and ocular involvement developed. On admission papular skin rash and partial visual loss with left eye were observed. Serological tests for syphilis were positive in very high titers. Ophthalmological examination revealed ocular abnormalities indicating ocular syphilis. Cerebrospinal fluid (CSF) tests showed elevated concentration of immunoglobulin G (IgG) with normal white blood count and albumin concentration, serological treponemal tests for syphilis were positive. Intravenous therapy with Penicillinum Crystallisatum (Benzylpenicillinum kalicum) was administered, according to the neurosyphilis treatment schedule, achieving resolution of the skin lesions and partial vision improvement, a month after the end of the treatment a complete recovery of the vision was noted. Serological tests` for syphilis titers decreased fourfold. Described case confirms reasonability of examination for syphilis in patients with sudden vision disturbances, especially those HIV-infected. It also indicates that early appropriate treatment of the ocular syphilis prevents permanent loss of vision.


Assuntos
Oftalmopatias , Infecções por HIV , Neurossífilis , Sífilis , Oftalmopatias/complicações , Oftalmopatias/diagnóstico , Oftalmopatias/tratamento farmacológico , Infecções por HIV/complicações , Humanos , Neurossífilis/complicações , Neurossífilis/diagnóstico , Neurossífilis/tratamento farmacológico , Polônia , Sífilis/complicações , Sífilis/diagnóstico , Sífilis/tratamento farmacológico
9.
Zhejiang Da Xue Xue Bao Yi Xue Ban ; 50(4): 420-428, 2021 Aug 25.
Artigo em Inglês | MEDLINE | ID: mdl-34704409

RESUMO

To investigate the national burden of eye diseases in China from 1990 to 2019. The national burden of eye diseases in China, including case numbers, prevalence rate, age-standardized prevalence rate (ASR), disability-adjusted life year (DALY), DALY rate and age-standardized DALY rate (ASD) were calculated and stratified by sex and age. The trends of eye diseases burden from 1990 to 2019 and the correlation between eye diseases burden and human development index (HDI) were analyzed. In 2019, the total case number of eye diseases in China was 0.21 billion, the ASR was 9511/10, the total number of DALY was 4.72 million, and the ASD was 247.4/10. Near vision loss caused the greatest burden, followed by refraction disorders and cataract, with ASD being 73.8/10, 70.3/10 and 59.2/10, respectively. Men had lower risks of eye diseases than women. People aged old and old had the greatest burden of eye diseases. Compared with the year 1990, the total case number increased by 134.6% and DALY by 113.0% in 2019. The ASD of all decreased by 7.5%, and was negatively correlated with national HDI. Near vision loss, refraction disorders and cataract are of heavy disease burden in China. Although the ASD of eye diseases is decreased with the development of the national socioeconomic status, the eye diseases burden in China still increased with population growth and aging.


Assuntos
Oftalmopatias , Saúde Global , Idoso , China/epidemiologia , Oftalmopatias/epidemiologia , Feminino , Humanos , Masculino , Anos de Vida Ajustados por Qualidade de Vida , Fatores Socioeconômicos
10.
BMJ Case Rep ; 14(10)2021 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-34667041

RESUMO

Porphyria cutanea tarda is the most common type of porphyria. It is associated with a deficiency of uroporphyrinogen decarboxylase enzyme responsible for heme synthesis. Clinical manifestations are predominantly dermatological and very rarely present with ocular involvement. Although scleral thinning in the interpalpebral area is a well-documented entity, sight-threatening corneal involvement is rarely described. We, herein report a case of a 58-year-old man who presented with ocular surface dryness, photophobia and mild redness. Slit-lamp biomicroscopy revealed corneo-scleral thinning in both eyes. The diagnosis was confirmed with a urine porphyrin test, serum iron and serum ferritin levels. We started him on conservative management after which he was lost to follow-up. He presented again after 6 years with total corneal opacification and progressive loss of vision in the right eye.


Assuntos
Oftalmopatias , Porfiria Cutânea Tardia , Humanos , Masculino , Pessoa de Meia-Idade , Fotofobia , Porfiria Cutânea Tardia/complicações , Porfiria Cutânea Tardia/diagnóstico , Esclera , Uroporfirinogênio Descarboxilase
11.
Int J Mol Sci ; 22(19)2021 Sep 27.
Artigo em Inglês | MEDLINE | ID: mdl-34638724

RESUMO

The ocular surface is a gateway that contacts the outside and receives stimulation from the outside. The corneal innate immune system is composed of many types of cells, including epithelial cells, fibroblasts, natural killer cells, macrophages, neutrophils, dendritic cells, mast cells, basophils, eosinophils, mucin, and lysozyme. Neutrophil infiltration and degranulation occur on the ocular surface. Degranulation, neutrophil extracellular traps formation, called NETosis, and autophagy in neutrophils are involved in the pathogenesis of ocular surface diseases. It is necessary to understand the role of neutrophils on the ocular surface. Furthermore, there is a need for research on therapeutic agents targeting neutrophils and neutrophil extracellular trap formation for ocular surface diseases.


Assuntos
Degranulação Celular , Córnea/metabolismo , Armadilhas Extracelulares/metabolismo , Oftalmopatias/metabolismo , Infiltração de Neutrófilos , Neutrófilos/metabolismo , Córnea/patologia , Oftalmopatias/patologia , Humanos , Neutrófilos/patologia
13.
J Am Chem Soc ; 143(43): 17891-17909, 2021 11 03.
Artigo em Inglês | MEDLINE | ID: mdl-34677069

RESUMO

The emergence of multi-drug-resistant pathogens threatens the healthcare systems world-wide. Recent advances in phototherapy (PT) approaches mediated by photo-antimicrobials (PAMs) provide new opportunities for the current serious antibiotic resistance. During the PT treatment, reactive oxygen species or heat produced by PAMs would react with the cell membrane, consequently leaking cytoplasm components and effectively eradicating different pathogens like bacteria, fungi, viruses, and even parasites. This Perspective will concentrate on the development of different organic photo-antimicrobials (OPAMs) and their application as practical therapeutic agents into therapy for local infections, wound dressings, and removal of biofilms from medical devices. We also discuss how to design highly efficient OPAMs by modifying the chemical structure or conjugating with a targeting component. Moreover, this Perspective provides a discussion of the general challenges and direction for OPAMs and what further needs to be done. It is hoped that through this overview, OPAMs can prosper and will be more widely used for microbial infections in the future, especially at a time when the global COVID-19 epidemic is getting more serious.


Assuntos
Anti-Infecciosos/química , Desenho de Fármacos , Fototerapia/métodos , Animais , Anti-Infecciosos/farmacologia , Anti-Infecciosos/uso terapêutico , Bactérias/efeitos dos fármacos , Biofilmes/efeitos dos fármacos , Biofilmes/efeitos da radiação , Corantes/química , Corantes/farmacologia , Equipamentos e Provisões/microbiologia , Equipamentos e Provisões/virologia , Escherichia coli/efeitos dos fármacos , Escherichia coli/fisiologia , Oftalmopatias/tratamento farmacológico , Oftalmopatias/patologia , Fungos/efeitos dos fármacos , Grafite/química , Luz , Nanopartículas/química , Nanopartículas/toxicidade , Fármacos Fotossensibilizantes/química , Fármacos Fotossensibilizantes/farmacologia , Fármacos Fotossensibilizantes/uso terapêutico , Teoria Quântica , Espécies Reativas de Oxigênio/metabolismo , Vírus/efeitos dos fármacos
14.
Sci Rep ; 11(1): 19817, 2021 10 06.
Artigo em Inglês | MEDLINE | ID: mdl-34615949

RESUMO

Recent studies have focused their attention on conjunctivitis as one of the symptoms of coronavirus disease 2019 (COVID-19). Therefore, tear samples were taken from COVID-19 patients and the presence of SARS-CoV-2 was evidenced using Real Time reverse transcription polymerase chain reaction. The main aim of this study was to analyze mRNA expression in the tears of patients with COVID-19 compared with healthy subjects using Next Generation Sequencing (NGS). The functional evaluation of the transcriptome highlighted 25 genes that differ statistically between healthy individuals and patients affected by COVID-19. In particular, the NGS analysis identified the presence of several genes involved in B cell signaling and keratinization. In particular, the genes involved in B cell signaling were downregulated in the tears of COVID-19 patients, while those involved in keratinization were upregulated. The results indicated that SARS-CoV-2 may induce a process of ocular keratinization and a defective B cell response.


Assuntos
COVID-19/genética , Oftalmopatias/virologia , Lágrimas/metabolismo , Transcriptoma , Idoso , Linfócitos B/metabolismo , COVID-19/patologia , COVID-19/virologia , Oftalmopatias/genética , Feminino , Sequenciamento de Nucleotídeos em Larga Escala/métodos , Humanos , Queratinas/metabolismo , Masculino , SARS-CoV-2/isolamento & purificação , Análise de Sequência de RNA/métodos , Pele/metabolismo , Pele/patologia , Pele/virologia , Lágrimas/virologia
15.
Int J Pharm ; 609: 121188, 2021 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-34655707

RESUMO

Ocular inflammation is one of the most common comorbidities associated to ophthalmic surgeries and disorders. Since conventional topical ophthalmic treatments present disadvantages such as low bioavailability and relevant side effects, natural alternatives constitute an unmet medical need. In this sense, lactoferrin, a high molecular weight protein, is a promising alternative against inflammation. However, lactoferrin aqueous instability and high nasolacrimal duct drainage compromises its potential effectiveness. Moreover, nanotechnology has led to an improvement in the administration of active compounds with compromised biopharmaceutical profiles. Here, we incorporate lactoferrin into biodegradable polymeric nanoparticles and optimized the formulation using the design of experiments approach. A monodisperse nanoparticles population was obtained with an average size around 130 nm and positive surface charge. Pharmacokinetic and pharmacodynamic behaviour were improved by the nanoparticles showing a prolonged lactoferrin release profile. Lactoferrin nanoparticles were non-cytotoxic and non-irritant neither in vitro nor in vivo. Moreover, nanoparticles exhibited significantly increased anti-inflammatory efficacy in cell culture and preclinical assays. In conclusion, lactoferrin loaded nanoparticles constitute a safe and novel nanotechnological tool suitable for the treatment of ocular inflammation.


Assuntos
Lactoferrina , Nanopartículas , Administração Oftálmica , Animais , Segmento Anterior do Olho , Disponibilidade Biológica , Oftalmopatias/tratamento farmacológico , Humanos , Inflamação/tratamento farmacológico , Soluções Oftálmicas , Tamanho da Partícula , Coelhos
16.
Vestn Oftalmol ; 137(5. Vyp. 2): 331-339, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34669345

RESUMO

The review presents data on damage to the organ of vision in patients recovered from the new coronavirus infection reflecting on the results obtained by various researchers from examining patients with varying severity of the disease, both during the active stage and after recovery. Possible ways of transmission of the infectious agent into the organ of vision were analyzed. The most common ocular manifestation of COVID-19 is conjunctivitis, while lesions of the retina and optic nerve were noted less often. The article also outlines the strategy for treatment and describes infection prevention measures for doctors and patients.


Assuntos
COVID-19 , Conjuntivite , Oftalmopatias/virologia , COVID-19/complicações , Conjuntivite/virologia , Humanos , Oftalmologia , SARS-CoV-2
17.
Med Sci Monit ; 27: e931863, 2021 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-34508064

RESUMO

During the coronavirus disease 2019 (COVID-19) pandemic, numerous reports of ocular anomalies occurring in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged. The most frequently reported pathology is conjunctivitis, which may be the first or only clinical manifestation of the disease. Involvement of SARS-CoV-2 in development of alterations in other ocular structures was suggested, including the cornea, the retina, and blood vessels. Possible mechanisms include direct activity of the viral agent, as well as systemic inflammatory response with accompanying thromboembolic complications. Genetic material of SARS-CoV-2 was detected in ocular secretions of infected individuals, including asymptomatic patients. Moreover, angiotensin-converting enzyme 2 (ACE2), a receptor protein used by the virus to enter the cell, has been found on the surface of various structures of the eye, which indicates a risk of transmission through ocular tissues. Therefore, it is crucial to use eye protection by medical professionals having contact with potentially infected patients. This paper is a review of the literature regarding ocular manifestations of SARS-CoV-2 infection and a summary of the current state of knowledge about possibility of transmission from an ophthalmology point of view. For data collection, a thorough PubMed search was performed, using the key words: "COVID ocular", "COVID eye", "SARS-CoV-2 ocular", and "SARS-CoV-2 eye". Conclusions: SARS-CoV-2 infection may manifest itself in various ocular conditions. Eye protection should not be neglected, as recent studies suggest the eye as a potential route of transmission. Further search for adequate safety measures in ophthalmology practice is required.


Assuntos
COVID-19/complicações , Oftalmopatias/virologia , COVID-19/transmissão , Humanos , SARS-CoV-2/patogenicidade
18.
Int J Pharm ; 608: 121105, 2021 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-34537269

RESUMO

The human eye is a complex organ with unique anatomy and physiology that restricts the delivery of drugs to target ocular tissues/sites. Recent advances in the field of pharmacy, biotechnology and material science have led to development of novel ophthalmic dosage forms which can provide sustained drug delivery, reduce dosing frequency and improve the ocular bioavailability of drugs. This review highlights the different anatomical and physiological factors which affect ocular bioavailability of drugs and explores advancements from 2016 to 2020 in various ophthalmic preparations. Different routes of drug administration such as topical, intravitreal, intraocular, juxtascleral, subconjunctival, intracameral and retrobulbar are discussed with their advances and limitations.


Assuntos
Oftalmopatias , Preparações Farmacêuticas , Administração Oftálmica , Disponibilidade Biológica , Sistemas de Liberação de Medicamentos , Olho , Oftalmopatias/tratamento farmacológico , Humanos , Soluções Oftálmicas
20.
Autoimmun Rev ; 20(11): 102944, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34509650

RESUMO

OBJECTIVE: Monogenic Autoinflammatory diseases (AIDs) are a broad spectrum of rare hereditary diseases whose ocular involvement has not been well characterized yet. This systematic review aims to provide an overview of the current knowledge about ocular findings in AIDs. METHODS: A systematic literature review was conducted using 2 electronic databases, according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. A combination of AIDs and ophthalmology-related search terms were used. All articles were screened by 2 independent reviewers for title, abstract and full text level. We included solely studies that investigated ocular findings in AIDs. RESULTS: 198 papers of 4268 records were retained. Data about 1353 patients with a diagnosis of autoinflammatory disease and ocular involvement were collected (680 CAPS, 211 FMF, 138 TRAPS, 238 Blau, 32 MKD, 21 SIFD, 7 Aicardi Goutières, 3 CANDLE, 8 DADA2, 9 HA20, 6 APLAID). Conjunctivitis was significantly more frequent in CAPS (p < 0.00001), uveitis in Blau, MKD, HA20 and CANDLE (p < 0.00001), papillitis/papilledema in CAPS (p < 0.00001), optic neuritis in Aicardi and DADA2 (p < 0.008), retinal vasculitis in FMF (p < 0.00001), progressive reduction in choroidal thickness in FMF and DADA2 (p < 0.00001), periorbital oedema in TRAPS (p < 0.00001) and retinitis in SIFD (p < 0.00001). Among AIDs with uveitis, granulomatous inflammation was more common in Blau syndrome (p < 0.00001). CONCLUSION: This systematic literature review characterized the ocular involvement of several AIDs, and the present data may encourage to consider a timely ophthalmological screening program for these rare diseases.


Assuntos
Doenças Autoimunes , Oftalmopatias , Doenças Hereditárias Autoinflamatórias , Olho , Doenças Hereditárias Autoinflamatórias/complicações , Doenças Hereditárias Autoinflamatórias/diagnóstico , Doenças Hereditárias Autoinflamatórias/genética , Humanos
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