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1.
Sci Total Environ ; 751: 141680, 2021 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-32890801

RESUMO

Non-targeted protein expression at the cellular level can provide insights into mechanistic effects of contaminants in wildlife, and hence new and potentially more accurate biomarkers of exposure and effect. However, this technique has been relatively unexplored in the realm of in vitro biomarker discovery in threatened wildlife, despite the vulnerability of this group of animals to adverse sublethal effects of contaminant exposure. Here we examined the usefulness of non-targeted protein expression for biomarker discovery in green sea turtles (Chelonia mydas) by investigating differences in the response of primary cells from five different tissue types that were exposed to three contaminants known to accumulate in this species. Cells derived from C. mydas skin, liver, kidney, ovary and small intestine were exposed to 100 µg/L of either polychlorinated biphenyl 153 (PCB153), perfluorononanoic acid (PFNA) or phenanthrene for 24 h. The global protein expression was then quantitatively evaluated using sequential window acquisition of all theoretical mass spectra (SWATH-MS). Comparison of the global protein profiles revealed that, while a majority of proteins were mutually expressed in controls of all tissue types (~90%), the response to exposure in terms of protein expression strength was significantly different between tissue types. Furthermore, a comparison to known markers of chemical exposure in sea turtles from the literature indicated that in vitro response can reflect known in vivo responses. In particular, markers such as heat shock protein (HSP) 60, glutathione S-transferases (GSTs) and superoxide dismutases (SODs), cytochrome P450 and catalase were dysregulated in response to exposure. Furthermore, potential new markers of exposure were discovered such as annexin, an important protein in cell signalling processes. While this methodology proved promising further studies are required to confirm the accuracy of in vitro protein expression as a tool for biomarker discovery in wildlife.


Assuntos
Bifenilos Policlorados , Tartarugas , Poluentes Químicos da Água , Animais , Biomarcadores , Feminino , Bifenilos Policlorados/análise , Pele/química , Poluentes Químicos da Água/análise , Poluentes Químicos da Água/toxicidade
2.
J Med Case Rep ; 14(1): 210, 2020 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-33138853

RESUMO

BACKGROUND: Since the World Health Organization declared a global pandemic due to the novel coronavirus disease2019, there have been targeted efforts to establish management modalities. Hydroxychloroquine has been suggested as a possible treatment; however, it is associated with multiple adverse reactions. We report a rare case of a patient with acute generalized exanthematous pustulosis with Stevens-Johnson syndrome due to hydroxychloroquine. Acute generalized exanthematous pustulosis is characterized by acute onset of a generalized rash that is pustular and erosive in nature, affecting limbs; trunk; face; and, less often, mucosal membranes. Although rare, it is important to be mindful of this side effect because the diagnosis is often delayed, and the disease has the potential to be life-threatening. CASE PRESENTATION: A 68-year-old American woman presented to our hospital with a painful, rapidly spreading rash. Its morphologic features included erythema multiforme-like lesions with extensive skin sloughing in various regions of the head, neck, and trunk and mucosal involvement. Her Nikolsky sign was negative, and she had no evidence of lesions on areas of skin trauma. Four weeks prior, she had been initiated on hydroxychloroquine for a presumed diagnosis of cutaneous sarcoidosis. Three punch biopsies of the head and neck area revealed subcorneal pustules consistent with acute generalized exanthematous pustulosis. Treatment began with high doses of methylprednisolone, leading to only minimal improvement of existing areas and ongoing spread to new areas. Treatment with intravenous immunoglobulin was initiated, at which point disease stability was achieved. The patient's rash ultimately resolved, as did her cutaneous pain and pruritus. CONCLUSIONS: Among many potential adverse reactions involving hydroxychloroquine, cutaneous side effects are varied and can lead to significant morbidity or even death. The drug is currently being investigated in a multitude of trials for coronavirus disease2019 treatment, prevention, and prophylaxis after exposure to severe acute respiratory syndrome coronavirus 2. Acute generalized exanthematous pustulosis is a rare side effect of hydroxychloroquine, and even fewer cases demonstrate histologic evidence of acute generalized exanthematous pustulosis while clinically presenting with Stevens-Johnson syndrome. Patients who develop Stevens-Johnson syndrome/toxic epidermal necrolysis require best supportive care with aggressive fluid and electrolyte replacement and prevention of further breakdown of the skin barrier. With the potential of widespread hydroxychloroquine use, it is important that providers be aware of its potential severe adverse drug reactions.


Assuntos
Pustulose Exantematosa Aguda Generalizada , Infecções por Coronavirus/epidemiologia , Hidroxicloroquina , Imunoglobulinas Intravenosas/administração & dosagem , Metilprednisolona/administração & dosagem , Pneumonia Viral/epidemiologia , Sarcoidose/tratamento farmacológico , Síndrome de Stevens-Johnson , Pustulose Exantematosa Aguda Generalizada/diagnóstico , Pustulose Exantematosa Aguda Generalizada/etiologia , Pustulose Exantematosa Aguda Generalizada/fisiopatologia , Pustulose Exantematosa Aguda Generalizada/terapia , Idoso , Antimaláricos/administração & dosagem , Antimaláricos/efeitos adversos , Biópsia/métodos , Feminino , Humanos , Hidroxicloroquina/administração & dosagem , Hidroxicloroquina/efeitos adversos , Fatores Imunológicos , Pandemias , Pele/patologia , Dermatopatias/tratamento farmacológico , Síndrome de Stevens-Johnson/diagnóstico , Síndrome de Stevens-Johnson/etiologia , Síndrome de Stevens-Johnson/fisiopatologia , Síndrome de Stevens-Johnson/terapia , Resultado do Tratamento
3.
Orv Hetil ; 161(46): 1959-1965, 2020 11 15.
Artigo em Húngaro | MEDLINE | ID: mdl-33190127

RESUMO

Összefoglaló. Két fiatal nobetegnél a valproátról lamotriginre történo gyógyszerátállítás során a 3-4. héten influenzaszeru prodromalis tüneteket követoen toxikus epidermalis necrolysis (TEN), más néven Lyell-szindróma alakult ki. Mindkét beteg 5 napja kezdodött bor- és nyálkahártyatünetekkel, kiterjedt hámleválást okozó hámnekrózissal került felvételre a Debreceni Egyetem Borgyógyászati Klinikájának Égési Intenzív Osztályára. Multidiszciplináris szupportív terápia mellett nagy dózisú szteroid- és immunglobulin-terápiát alkalmaztunk. A 37 éves nobetegnél 3 hét után a kórkép fatális kimenetellel végzodött. A 19 éves nobeteg tünetei 4 hét intenzív terápia után szövodményekkel gyógyultak. A TEN ritka, gyógyszer által okozott, életet veszélyezteto, késoi hiperszenzitivitási reakció. Patogenezisében a gyógyszermolekula, a humán leukocytaantigén (HLA) I. osztályú molekula és a T-sejt-receptor kóros interakciója szerepel. Kezelésében a legfontosabb a kiváltó gyógyszer elhagyása, valamint az azonnal kezdett komplett szupportív terápia alkalmazása. A specifikus kezelést illetoen nincsenek egységes szakmai irányelvek. A veszélyes gyógyszerek titrált bevezetése csökkentheti a kialakuló hiperszenzitivitás súlyosságát, ezenfelül a beteg szoros követése és az adverz tünetek korai felismerése javíthatja a TEN kimenetelét. Orv Hetil. 2020; 161(46): 1959-1965. Summary. After switching from valproate to lamotrigine, on the 3rd-4th weeks, two young female patients developed flu-like prodromal symptoms, followed by the development of toxic epidermal necrolysis (TEN), also known as Lyell syndrome. Both patients were admitted to the Burn Intensive Care Unit of the Department of Dermatology, University of Debrecen with skin and mucosa symptoms; extensive epithelial death and detachment started 5 days earlier. In addition to multidisciplinary supportive treatment, high-dose corticosteroid and immunoglobulin therapy were administered. In the case of the 37-year-old female patient, the disease resulted in a fatal outcome. The 19-year-old patient healed with some sequelae. TEN is a rare, life-threatening delayed-type hypersensitivity reaction caused by drugs. Its pathogenesis involves an interaction between small-molecule drug, human leukocyte antigen class I molecule and T-cell receptor. The most important treatment is immediate withdrawal of potentially causative drugs and prompt application of supportive therapy. There is no standard guidance on specific treatment. Slow dose escalation of dangerous drugs can be beneficial in avoiding severe reactions, furthermore, close patient follow-up and early detection of the possible adverse reactions contribute to a more favourable outcome of TEN. Orv Hetil. 2020; 161(46): 1959-1965.


Assuntos
Anticonvulsivantes , Lamotrigina , Síndrome de Stevens-Johnson , Corticosteroides , Adulto , Anticonvulsivantes/efeitos adversos , Feminino , Humanos , Lamotrigina/efeitos adversos , Masculino , Pele , Adulto Jovem
4.
Harefuah ; 159(11): 820-822, 2020 Nov.
Artigo em Hebraico | MEDLINE | ID: mdl-33210853

RESUMO

INTRODUCTION: Cutaneous lupus is an autoimmune disease that can be represented individually or as part of the systemic disease, systemic lupus erythematosus (SLE). Initial presentation of skin manifestations, such as chronic urticatia, should raise the possibility that it might be the first manifestation of an active disease, for example SLE. Despite the broad differential diagnosis of chronic urticaria, other plausible diagnosis should be ruled out with complete anamnesis that includes family background, substance exposure, new and chronic drug therapy, serological and immunological blood tests, diagnostic biopsy of the skin and imaging as needed to rule out malignancy. We present a case of a patient with a family history of various autoimmune diseases, who presented with chronic urticatia and joint pain with partial response to steroid therapy over a period of several months.


Assuntos
Doenças Autoimunes , Urticária Crônica , Lúpus Eritematoso Sistêmico , Doenças Autoimunes/diagnóstico , Biópsia , Diagnóstico Diferencial , Humanos , Pele
5.
J Toxicol Sci ; 45(11): 725-735, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33132246

RESUMO

The purpose of this study was to evaluate the sensitization potential of 82 compounds classified as volatile and/or semi-volatile organic compounds using the direct peptide reactivity assay (DPRA), given that these chemical compounds have been detected frequently and at high concentrations in a national survey of Japanese indoor air pollution and other studies. The skin sensitization potential of 81 of these compounds was evaluable in our study; one compound co-eluted with cysteine peptide and was therefore not evaluable. Twenty-five of the evaluated compounds were classified as positive. Although all glycols and plasticizers detected frequently and at high concentrations in a national survey of Japanese indoor air pollution were negative, hexanal and nonanal, which are found in fragrances and building materials, tested positive. Monoethanolamine and 1,3-butanediol, which cause clinical contact dermatitis, and several compounds reported to have weak sensitization potential in animal studies, were classified as negative. Thus, it was considered that compounds with weak sensitization potential were evaluated as negative in the DPRA. Although the sensitization potential of the formaldehyde-releasing preservative bronopol has been attributed to the release of formaldehyde (a well-known contact allergen) by its degradation, its degradation products-bromonitromethane and 2-bromoethanol-were classified as positive, indicating that these degradation products also exhibit sensitization potential. The compounds that tested positive in this study should be comprehensively assessed through multiple toxicity and epidemiological studies.


Assuntos
Poluição do Ar em Ambientes Fechados/análise , Testes de Irritação da Pele/métodos , Compostos Orgânicos Voláteis/análise , Compostos Orgânicos Voláteis/toxicidade , Aldeídos , Animais , Biodegradação Ambiental , Dermatite de Contato/etiologia , Formaldeído , Glicolatos , Humanos , Japão , Odorantes , Peptídeos , Plastificantes , Pele , Compostos Orgânicos Voláteis/classificação
6.
Pol Merkur Lekarski ; 48(287): 331-334, 2020 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-33130793

RESUMO

Among the high-tech methods of wound therapy, the leading place belongs to the technology of manufacture and use of cryolyophilized tissues and bioorganic drugs. Crushed xenoderm's powder stimulates the regenerative processes of the skin and improves the healing process of wounds, as it is enriched with macro- and microelements, amino acids and other cellular elements necessary for skin regeneration. AIM: The aim of this work was to study the wound-healing effectiveness of the developed gel "Xeliogel" on the animal model of aseptic superficial burns. MATERIALS AND METHODS: Evaluation of the degree of catabolism and membrane-destructive processes was performed by determining the marker enzymes of cytolysis - aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum, total protein and middle molecular mass in animals with experimental thermal burns. The developed gel "Xeliogel" was applied to the animals for therapeutic purposes. "Xeliogel" is based on aqueous extraction of xenoderm and with lidocaine hydrochloride. In the second group for comparison the Solcoseryl was applied in the form of a gel (Switzerland). This medicine belongs to the group containing active pharmaceutical ingredients of natural origin, namely protein-free dialysate from the blood of calves, and is intended for the treatment of burns of I-II degrees. RESULTS: When using the developed gel "Xeliogel" in experimental thermal burns, normalization of total protein was observed on 14-th days, which is on 7 days faster than under burn conditions, decrease the levels of ALT and AST in the serum with a return to a normal on a 7 day, relative to the control pathology group. In the groups of animals, on whose burn wounds "Xeliogel" gel was applied, already on the 14-th day endogenous intoxication was significantly reduced by 29 % compared with the control group of animals. During the experiment to reduce the area of the wound surface, it was determined that the developed gel "Xeliogel" showed a pharmacological effect similar to the comparison drug "Solkoseryl" gel. CONCLUSIONS: On the model of aseptic burn injury in rats, was determined that the developed gel provides a significant reduction in necrotic processes, the level of endogenous intoxication against the background of restoring the level of total protein in the circulating blood. The results of the research confirm the effectiveness of using the developed gel "Xeliogel" for local treatment of burns of I-II degrees, as the duration of treatment of burns reduced by 4 days compared to the control group and the developed gel is similar to the comparison drug.


Assuntos
Queimaduras , Animais , Queimaduras/tratamento farmacológico , Bovinos , Humanos , Ratos , Pele , Cicatrização
7.
Chemosphere ; 261: 128051, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33113650

RESUMO

The potential toxicity of copper nanoparticles (CuNPs) to early stages of fishes is not fully understood, and little is known about their effects on ionocytes and associated functions. This study used zebrafish embryos as a model to investigate the toxic effects of CuNPs on two subtypes of ionocytes. Zebrafish embryos were exposed to 0.1, 1, and 3 mg L-1 CuNPs for 96 h. After exposure, whole-body Na+ and Ca2+ contents were significantly reduced at ≥0.1 mg L-1, while the K+ content had decreased at ≥1 mg L-1. H+ and NH4+ excretion by the skin significantly decreased at ≥1 mg L-1. The number of living ionocytes labeled with rhodamine-123 had significantly decreased with ≥0.1 mg L-1 CuNPs. The ionocyte subtypes of H+-ATPase-rich (HR) and Na+/K+-ATPase-rich (NaR) cells were labeled by immunostaining and had decreased with ≥1 mg L-1. Shrinkage of the apical opening of ionocytes was revealed by scanning electronic microscopy. Functional impairment was also reflected by changes in gene expressions, including ion transporters/channels and Ca2+-regulatory hormones. This study shows that CuNP exposure can impair two subtypes of ionocytes and their associated functions, including Na+/Ca2+ uptake and H+/NH4+ excretion in zebrafish embryos.


Assuntos
Amônia/metabolismo , Cobre/toxicidade , Embrião não Mamífero/efeitos dos fármacos , Nanopartículas/toxicidade , Poluentes Químicos da Água/toxicidade , Peixe-Zebra/metabolismo , Ácidos/metabolismo , Animais , Transporte Biológico , Cálcio/metabolismo , Cobre/metabolismo , Embrião não Mamífero/metabolismo , Canais Iônicos/metabolismo , Íons/metabolismo , Nanopartículas/metabolismo , Pele/metabolismo , Sódio/metabolismo , ATPase Trocadora de Sódio-Potássio/metabolismo , Poluentes Químicos da Água/metabolismo , Proteínas de Peixe-Zebra/metabolismo
8.
J Cosmet Sci ; 71(4): 209-216, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33022205

RESUMO

Our defense against solar ultraviolet (UV) damage to skin comprises endogenous mechanisms of DNA repair and pigmentation, and exogenous application of light-absorbing and reflecting sunscreens. Our most important endogenous defense, DNA repair, has been the focus of molecular and clinical research, and recent advances are summarized here. The approach of using microbial DNA repair enzymes to augment the natural DNA repair capacity of skin has gained acceptance in many commercial products, and clinical studies have supported their benefits.


Assuntos
Reparo do DNA , Raios Ultravioleta , Pele , Luz Solar , Protetores Solares
9.
J Cosmet Sci ; 71(4): 199-208, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33022204

RESUMO

Skin exposure to solar radiation can cause many adverse effects. In addition to the sun protection factor (SPF), a parameter associated with Ultraviolet B (UVB) protection, significant evidence emphasized the crucial importance of a well-balanced protection against ultraviolet A (UVA) and for some indications, against high-energy visible light. Synergy between UV filters and filter photostability together with film-forming ingredients such as polymers that ensure the homogeneous distribution of UV filters on the skin are key factors to avoid UVA- and UVB-provoked detrimental effects of solar radiation. Clinical studies mimicking real conditions of use have been performed. The results show that a well-balanced sunscreen with at least an SPF-to-UVA protection factor ratio < 3 provides the most effective protection against DNA damage, skin photoimmunosuppression, photodermatoses, and pigmentation disorders. In addition, cosmetically pleasant sunscreens allow a sufficient amount to be applied and re-applied by consumers, ensuring continuous and even coverage of the exposed skin.


Assuntos
Raios Ultravioleta , Pele , Fator de Proteção Solar , Luz Solar , Protetores Solares , Raios Ultravioleta/efeitos adversos
11.
Int J Dermatol ; 59(12): 1475-1484, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33070314

RESUMO

BACKGROUND: Many cutaneous manifestations have been described in possible association with the COVID-19 pandemic, including acral lesions resembling chilblains. The underlying pathomechanisms of COVID-19 chilblains are not fully understood. The aim of this study was to describe the clinical, pathological, and laboratory findings of a series of patients who developed chilblains during the COVID-19 outbreak and to investigate the possible factors that could be involved in the pathogenesis of these lesions. METHODS: We conducted a prospective cohort study that included 54 patients who presented with chilblains during the highest peak in the incidence of COVID-19 in Cantabria (northern Spain). Skin biopsies were performed on 10 of these patients who presented with recent lesions. Laboratory investigations, including immunological analysis, serological studies, and the assessment of cryoproteins, were also performed. RESULTS: Most patients presented erythematous plaques located on the toes and/or purpuric macules located on the feet. Histopathological findings were compatible with those of idiopathic chilblains. Immunohistochemical evaluation showed C3d and C4d deposits in the vessel walls in seven cases. The autoimmunity panel was negative in most of our series. Cryoprotein testing showed positive cryofibrinogen in two-thirds (66.7%) of the patients assessed. On follow-up, most patients presented almost complete resolution, although six patients required prednisone and antiaggregant drug treatment. CONCLUSIONS: This study shows, for the first time to our knowledge, a high prevalence of cryofibrinogenemia in patients with chilblains during the COVID-19 pandemic. Cryofibrinogenemia could be implicated in the pathogenesis of chilblains related to COVID-19.


Assuntos
Betacoronavirus/isolamento & purificação , Pérnio/sangue , Infecções por Coronavirus/complicações , Crioglobulinemia/epidemiologia , Pneumonia Viral/complicações , Adolescente , Adulto , Idoso , Biópsia , Pérnio/diagnóstico , Pérnio/epidemiologia , Pérnio/etiologia , Criança , Infecções por Coronavirus/sangue , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/epidemiologia , Crioglobulinemia/sangue , Crioglobulinemia/diagnóstico , Crioglobulinemia/etiologia , Crioglobulinas/análise , Feminino , Fibrinogênios Anormais/análise , Humanos , Masculino , Pessoa de Meia-Idade , Pandemias , Pneumonia Viral/sangue , Pneumonia Viral/diagnóstico , Pneumonia Viral/epidemiologia , Prevalência , Estudos Prospectivos , Pele/patologia , Espanha/epidemiologia , Adulto Jovem
13.
Harefuah ; 159(10): 731-734, 2020 Oct.
Artigo em Hebraico | MEDLINE | ID: mdl-33103391

RESUMO

INTRODUCTION: Langerhans cell histiocytosis (LCH) is rare during the newborn period. The term is used to describe a disorder characterized by infiltration of Langerhans cells into various organs. Langerhans cells are derived from the bone marrow, and are a type of dendritic cells found primarily in the epidermis. LCH may involve multiple organ systems, the most common being the skin and the bones. Cutaneous involvement is very common in LCH, and is often the presenting symptom. The most classic presentation is that of seborrheic dermatitis like eruption. Papules, petechiae, erosions and vesicles were also described. In our present case we describe a neonate with vesiculopustular rash appearing immediately after birth with an unexpected diagnosis made by skin biopsy.


Assuntos
Histiocitose de Células de Langerhans , Biópsia , Histiocitose de Células de Langerhans/diagnóstico , Humanos , Recém-Nascido , Pele
15.
Nature ; 586(7830): 504-506, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-33028991
16.
Cell Prolif ; 53(11): e12916, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33058377

RESUMO

Healing after mammalian skin injury involves the interaction between numerous cellular constituents and regulatory factors, which together form three overlapping phases: an inflammatory response, a proliferation phase and a remodelling phase. Any slight variation in these three stages can substantially alter the healing process and resultant production of scars. Of particular significance are the mechanisms responsible for the scar-free phenomenon observed in the foetus. Uncovering such mechanisms would offer great expectations in the treatment of scars and therefore represents an important area of investigation. In this review, we provide a comprehensive summary of studies on injury-induced skin regeneration within the foetus. The information contained in these studies provides an opportunity for new insights into the treatment of clinical scars based on the cellular and molecular processes involved.


Assuntos
Cicatriz/fisiopatologia , Pele/fisiopatologia , Cicatrização , Adulto , Animais , Cicatriz/patologia , Feto/patologia , Feto/fisiopatologia , Fibroblastos/patologia , Humanos , Queratinócitos/patologia , Lesões Pré-Natais/patologia , Lesões Pré-Natais/fisiopatologia , Pele/embriologia , Pele/lesões , Pele/patologia
17.
Int J Nanomedicine ; 15: 7627-7650, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33116492

RESUMO

The skin is the largest organ in the human body, providing a barrier to the external environment. It is composed of three layers: epidermis, dermis and hypodermis. The most external epidermis is exposed to stress factors that may lead to skin conditions such as photo-aging and skin cancer. Some treatments for skin disease utilize the incorporation of drugs or bioactive compounds into nanocarriers known as liposomes. Liposomes are membranes whose sizes range from nano to micrometers and are composed mostly of phospholipids and cholesterol, forming similar structures to cell membranes. Thus, skin treatments with liposomes have lower toxicity in comparison to traditional treatment routes such as parenteral and oral. Furthermore, addition of edge activators to the liposomes decreases the rigidity of the bilayer structure making it deformable, thereby improving skin permeability. Liposomes are composed of an aqueous core and a lipidic bilayer, which confers their amphiphilic property. Thus, they can carry hydrophobic and hydrophilic compounds, even simultaneously. Current applications of these nanocarriers are mainly in the cosmetic and pharmaceutic industries. Nevertheless, new research has revealed promising results regarding the effectiveness of liposomes for transporting bioactive compounds through the skin. Liposomes have been well studied; however, additional research is needed on the efficacy of liposomes loaded with bioactive peptides for skin delivery. The objective of this review is to provide an up-to-date description of existing techniques for the development of liposomes and their use as transporters of bioactive compounds in skin conditions such as melanoma and skin inflammation. Furthermore, to gain an understanding of the behavior of liposomes during the process of skin delivery of bioactive compounds into skin cells.


Assuntos
Inflamação/patologia , Melanoma/tratamento farmacológico , Neoplasias Cutâneas/tratamento farmacológico , Pele/patologia , Transporte Biológico , Humanos , Lipossomos/ultraestrutura , Absorção Cutânea
18.
Hautarzt ; 71(11): 835-842, 2020 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-33044558

RESUMO

Diabetes mellitus (DM) is a paramount and rising medical challenge in both industrial and emerging nations. For Germany, 6.9 million out of 64.9 million insured persons in 2010 were reported to suffer from DM and approximately 5.8 million suffered from type 2 DM. The prevalence of diabetic foot ulcer (DFU) or diabetic foot syndrome (DFS) is 2-10% and the incidence is 2-6%. In addition, patients with DM present associated skin disorders with chronic wound healing, e.g., pyoderma gangrenosum or lecrobiosis lipoidica. Knowledge of the pathogenesis and skills for treatment of chronic wounds in diabetic patients are important for dermatologists. Patients with diabetes and wound healing disorders and accompanied unspecific skin disorders like eczema, cellulitis or contact dermatitis are often primarily or secondarily treated by dermatologists. In this article, practical hints for the treatment of DFS and other chronic wound in patients with DM are presented.


Assuntos
Diabetes Mellitus , Pé Diabético , Pé Diabético/diagnóstico , Pé Diabético/epidemiologia , Pé Diabético/terapia , Alemanha/epidemiologia , Humanos , Incidência , Pele , Cicatrização
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