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1.
Cell Rep ; 40(10): 111314, 2022 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-36070692

RESUMO

Host immune response via Th17 cells against oral pathobionts is a key mediator in periodontitis development. However, where and how the Th17-type immune response is induced during the development of periodontitis is not well understood. Here, we demonstrate that gut translocation of the oral pathobiont Porphyromonas gingivalis (Pg) exacerbates oral pathobiont-induced periodontitis with enhanced Th17 cell differentiation. The oral pathobiont-responsive Th17 cells are differentiated in Peyer's patches and translocated systemically in the peripheral immune tissues. They are also capable of migrating to and accumulating in the mouth upon oral infection. Development of periodontitis via the oral pathobiont-responsive Th17 cells is regulated by the intestinal microbiome, and altering the intestinal microbiome composition with antibiotics affects the development of periodontitis. Our study highlights that pathobiont-responsive Th17 cells in the gut-mouth axis and the intestinal microbiome work together to provoke inflammatory oral diseases, including periodontitis.


Assuntos
Microbioma Gastrointestinal , Periodontite , Humanos , Porphyromonas gingivalis/fisiologia , Células Th17
2.
Dis Markers ; 2022: 8611755, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36072904

RESUMO

Objective: To screen for potential endoplasmic reticulum stress- (ERS-) related biomarkers of periodontitis using machine learning methods and explore their relationship with immune cells. Methods: Three datasets of periodontitis (GSE10334, GES16134, and GES23586) were obtained from the Gene Expression Omnibus (GEO), and the samples were randomly assigned to the training set or the validation set. ERS-related differentially expressed genes (DEGs) between periodontitis and healthy periodontal tissues were screened and analyzed for GO, KEGG, and DO enrichment. Key DEGs were screened by two machine learning algorithms, LASSO regression and support vector machine-recursive feature elimination (SVM-RFE); then, the potential biomarkers were identified through validation. The infiltration of immune cells of periodontitis was calculated using the CIBERSORT algorithm, and the correlation between immune cells and potential biomarkers was specifically analyzed through the Spearman method. Results: We obtained 36 ERS-related DEGs of periodontitis from the training set, from which 11 key DEGs were screened by further machine learning. SERPINA1, ERLEC1, and VWF showed high diagnostic values (AUC > 0.85), so they were considered as potential biomarkers for periodontitis. According to the results of the immune cell infiltration analysis, these three potential biomarkers showed marked correlations with plasma cells, neutrophils, resting dendritic cells, resting mast cells, and follicular helper T cells. Conclusions: Three ERS-related genes, SERPINA1, ERLEC1, and VWF, showed valuable biomarker potential for periodontitis, which provide a target base for future studies on early diagnosis and treatment of periodontitis.


Assuntos
Biologia Computacional , Periodontite , Biomarcadores , Biologia Computacional/métodos , Estresse do Retículo Endoplasmático , Perfilação da Expressão Gênica/métodos , Humanos , Periodontite/genética , Máquina de Vetores de Suporte , Fator de von Willebrand
4.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 57(9): 973-977, 2022 Sep 09.
Artigo em Chinês | MEDLINE | ID: mdl-36097948

RESUMO

Vascular endothelium formulates the basic defense against cardiovascular diseases. Multiple factors such as inflammatory factors, oxidative stress and biological factors can cause endothelial dysfunction and be involved in the formation and development of cardiovascular diseases. In studies of recent years, accumulated evidences showed that periodontitis was an independent risk factor for cardiovascular events, and was related to vascular endothelial dysfunction. Periodontal therapy could improve the vascular endothelial function. In this paper, the epidemiological evidences of associations between periodontitis and vascular endothelial dysfunction in recent years were listed, and the possible mechanisms of periodontitis aggravating endothelial dysfunction were analyzed. The importance of periodontal intervention in improving endothelial function was emphasized. This will provide new ideas for further study about the relationship between periodontitis and cardiovascular diseases and for the prevention and treatment strategies.


Assuntos
Doenças Cardiovasculares , Periodontite , Doenças Cardiovasculares/etiologia , Endotélio Vascular , Humanos , Estresse Oxidativo , Periodontite/complicações , Fatores de Risco
5.
Nutrients ; 14(17)2022 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-36079777

RESUMO

Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin have recently received the most attention among these molecules due to their documented antioxidant effects. The review aims to investigate the effects of these molecules on bone metabolism and their role in several diseases such as osteopenia and osteoporosis, bone tumours, and periodontitis. The PubMed/Medline, Web of Science, Google Scholar, Scopus, Cochrane Library, and Embase electronic databases were searched for papers in line with the study topic. According to an English language restriction, the screening period was from January 2012 to 3 July 2022, with the following Boolean keywords: ("resveratrol" AND "bone"); ("curcumin" AND "bone"); ("quercetin" AND "bone"). A total of 36 papers were identified as relevant to the purpose of our investigation. The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis. Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration. According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies. The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.


Assuntos
Curcumina , Osteoporose , Periodontite , Curcumina/química , Curcumina/farmacologia , Suplementos Nutricionais , Humanos , Osteoporose/tratamento farmacológico , Osteoporose/prevenção & controle , Quercetina/química , Quercetina/farmacologia , Resveratrol/farmacologia
6.
Int J Mol Sci ; 23(17)2022 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-36077282

RESUMO

Rheumatoid arthritis (RA) and periodontitis are suggested to be closely linked based on microbial dysbiosis, but limited subgingival bacteria have been proven in the pathogenesis of RA. We enrolled 30 RA patients and 25 controls and divided them into three groups with matched age, gender, and diabetes statuses: group AM (all of the matched participants), group PD (periodontally diseased), and group PH (periodontally healthy). Their subgingival microbial composition was determined by V3-V4 16S rRNA gene sequencing. Significant differences in subgingival microbial clustering between the RA patients and controls were observed in groups AM and PD. Among the taxa enriched in RA, Aminipila butyrica and Peptococcus simiae were the only two species displaying positive correlation to the level of anti-citrullinated protein antibodies (ACPAs) in both of the groups. Surprisingly, the median of relative abundances of A. butyrica and P. simiae were 0% in the controls of group PD. Furthermore, a gene encoding arginine deiminase with the capability to produce citrulline was addressed in the complete genome sequence of A. butyrica. This is the first study to elucidate the important roles of A. butyrica and P. simiae as periodontal bacteria leading to RA possibly through the induction of ACPA production.


Assuntos
Artrite Reumatoide , Microbiota , Periodontite , Anticorpos Anti-Proteína Citrulinada , Autoanticorpos , Bactérias/genética , Humanos , Microbiota/genética , Periodontite/microbiologia , RNA Ribossômico 16S/genética
7.
Wiad Lek ; 75(8 pt 2): 1960-1964, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36129078

RESUMO

OBJECTIVE: The aim: Investigate structural changes in the tissues of the periodontal complex under the condition of experimental lipopolysaccharide periodontitis combined with hyper¬thyroidism. PATIENTS AND METHODS: Materials and methods: The studies were performed on adult white male rats, which simulated periodontitis combined with hyperthyroidism. Periodontal tissues were subjected to morphological examination on the 22nd day of the experiment. Collection of material for microscopic examinations was performed according to the generally accepted method; histological specimens were studied using a light optical microscope. RESULTS: Results: Morphological studies of the components of the periodontal complex of experimental animals with experimental periodontitis established the reorganization of its structural elements. Damage to the epithelium in the area of attachment of the circular ligament and erosive-ulcerative changes of the gums led to a deepening of the gingival sulcus with the formation of a deep periodontal pocket. Intense hyperkeratosis was observed in the area of the bottom of the periodontal pocket. In the own plate of the mucous membrane of the gums - significant edema, collagen fibers were disorganized, defragmented. There were pronounced destructive-degenerative and inflammatory changes of the epithelial and own plates of all areas of the gums and periodontium, damage to the nuclei and cytoplasm of keratinocytes, fibroblasts, and leukocytes. CONCLUSION: Conclusions: Experimental periodontitis combined with hyperthyroidism is accompanied by pronounced signs of destructive and inflammatory changes in the soft and dense tissues of the periodontal complex, as well as disruption of stromal-vascular interactions, which progress from reversible to irreversible disruption of periodontal connective tissue.


Assuntos
Hipertireoidismo , Periodontite , Animais , Colágeno , Hipertireoidismo/complicações , Lipopolissacarídeos , Masculino , Bolsa Periodontal , Periodontite/complicações , Ratos
8.
J Am Geriatr Soc ; 70(9): 2695-2709, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36073186

RESUMO

BACKGROUND: Emerging evidence indicates that poor periodontal health adversely impacts cognition. This review examined the available longitudinal evidence concerning the effect of poor periodontal health on cognitive decline and dementia. METHODS: Comprehensive literature search was conducted on five electronic databases for relevant studies published until April 2022. Longitudinal studies having periodontal health as exposure and cognitive decline and/or dementia as outcomes were considered. Random effects pooled estimates and 95% confidence intervals were generated (pooled odds ratio for cognitive decline and hazards ratio for dementia) to assess whether poor periodontal health increases the risk of cognitive decline and dementia. Heterogeneity between studies was estimated by I2 and the quality of available evidence was assessed through quality assessment criteria. RESULTS: Adopted search strategy produced 2132 studies for cognitive decline and 2023 for dementia, from which 47 studies (24 for cognitive decline and 23 for dementia) were included in this review. Poor periodontal health (reflected by having periodontitis, tooth loss, deep periodontal pockets, or alveolar bone loss) was associated with both cognitive decline (OR = 1.23; 1.05-1.44) and dementia (HR = 1.21; 1.07-1.38). Further analysis, based on measures of periodontal assessment, found tooth loss to independently increase the risk of both cognitive decline (OR = 1.23; 1.09-1.39) and dementia (HR = 1.13; 1.04-1.23). Stratified analysis based on the extent of tooth loss indicated partial tooth loss to be important for cognitive decline (OR = 1.50; 1.02-2.23) and complete tooth loss for dementia (HR = 1.23; 1.05-1.45). However, the overall quality of evidence was low, and associations were at least partly due to reverse causality. CONCLUSIONS: Poor periodontal health and tooth loss appear to increase the risk of both cognitive decline and dementia. However, the available evidence is limited (e.g., highly heterogenous, lacking robust methodology) to draw firm conclusions. Further well-designed studies involving standardized periodontal and cognitive health assessment and addressing reverse causality are highly warranted.


Assuntos
Disfunção Cognitiva , Demência , Periodontite , Perda de Dente , Disfunção Cognitiva/complicações , Disfunção Cognitiva/epidemiologia , Demência/complicações , Demência/etiologia , Humanos , Estudos Longitudinais , Perda de Dente/complicações , Perda de Dente/epidemiologia
9.
Dis Markers ; 2022: 4030046, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36133437

RESUMO

Objective: To identify the N6-methyladenosine (m6A) methylation regulator genes linking prostate adenocarcinoma (PRAD) and periodontitis (PD). Materials and Methods: PD and TCGA-PRAD GEO datasets were downloaded and analyzed through differential expression analysis to determine the differentially expressed genes (DEGs) deregulated in both conditions. Twenty-three m6A RNA methylation-related genes were downloaded in total. The m6A-related genes that overlapped between PRAD and PD were identified as crosstalk genes. Survival analysis was performed on these genes to determine their prognostic values in the overall survival outcomes of prostate cancer. The KEGG pathways were the most significantly enriched by m6A-related crosstalk genes. We also performed lasso regression analysis and univariate survival analysis to identify the most important m6A-related crosstalk genes, and a protein-protein interaction (PPI) network was built from these genes. Results: Twenty-three m6A methylation-related regulator genes were differentially expressed and deregulated in PRAD and PD. Among these, seven (i.e., ALKBH5, FMR1, IGFBP3, RBM15B, YTHDF1, YTHDF2, and ZC3H13) were identified as m6A-related cross-talk genes. Survival analysis showed that only the FMR1 gene was a prognostic indicator for PRAD. All other genes had no significant influence on the overall survival of patients with PRAD. Lasso regression analysis and univariate survival analysis identified four m6A-related cross-talk genes (i.e., ALKBH5, IGFBP3, RBM15B, and FMR1) that influenced risk levels. A PPI network was constructed from these genes, and 183 genes from this network were significantly enriched in pathogenic Escherichia coli infection, p53 signaling pathway, nucleocytoplasmic transport, and ubiquitin-mediated proteolysis. Conclusion: Seven m6A methylation-related genes (ALKBH5, FMR1, IGFBP3, RBM15B, YTHDF1, YTHDF2, and ZC3H13) were identified as cross-talk genes between prostate cancer and PD.


Assuntos
Periodontite , Neoplasias da Próstata , Proteína do X Frágil de Retardo Mental/genética , Humanos , Masculino , Metilação , Neoplasias da Próstata/genética , RNA/genética , Transcriptoma , Proteína Supressora de Tumor p53/genética , Ubiquitinas/genética
10.
Eur J Med Res ; 27(1): 181, 2022 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-36114562

RESUMO

AIM: Aim of this study was to investigate the association between periodontitis and arterial hypertension, both of which show correlations with classical cardiovascular risk factors and inflammatory activity. MATERIALS AND METHODS: A cross-sectional analysis of data from a large population-based health survey (the Hamburg City Health Study, HCHS) including 5934 participants with complete periodontal examination and blood pressure data, of whom 5735 had medical records regarding anti-hypertensive medication, was performed. Probing depths, gingival recessions, bleeding on probing (BOP), dental plaque, and decayed-missing-filled teeth (DMFT) indices were recorded as measures of oral health. Clinical attachment loss (CAL) per tooth was calculated and periodontitis was staged into three groups (no/mild, moderate, severe). Arterial hypertension was diagnosed based on the participants' medication history and systolic and diastolic blood pressure values. Logistic regression models were constructed accounting for a set of potential confounders (age, sex, smoking, body mass index (BMI), diabetes, educational level, alcohol intake) and high sensitivity-C-reactive protein (hsCRP). RESULTS: The odds of arterial hypertension increased significantly along with periodontitis severity (OR for severe periodontitis: 2.19; 95% CI 1.85-2.59; p < 0.001; OR for moderate periodontitis: 1.65; 95% CI 1.45-1.87; p < 0.001). Participants with moderate or severe periodontitis also had significantly higher age- and sex-adjusted odds of arterial hypertension, which was slightly weakened when additionally adjusted for BMI, diabetes, smoking, educational level, and alcohol intake (OR for severe PD: 1.28, 95% CI 1.04-1.59, p = 0.02; OR for moderate PD: 1.30, 95% CI 1.11-1.52, p = 0.001). The fraction of participants with undertreated hypertension (untreated and poorly controlled hypertension) was considerably larger in participants with severe periodontitis than in those with no/mild periodontitis (50.1% vs. 37.4% for no/mild periodontitis). CONCLUSIONS: The study shows an association between periodontitis and arterial hypertension that is independent of age, sex, diabetes, BMI, smoking, educational level, and alcohol intake. In addition, undertreatment of hypertension was more common in people with severe periodontitis compared with periodontally more healthy people.


Assuntos
Diabetes Mellitus , Hipertensão , Periodontite , Anti-Hipertensivos , Proteína C-Reativa , Estudos Transversais , Humanos , Hipertensão/complicações , Hipertensão/epidemiologia , Periodontite/complicações , Periodontite/epidemiologia
11.
Oxid Med Cell Longev ; 2022: 9728172, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36148415

RESUMO

Methods: The differentially expressed genes (DEGs) were identified using periodontitis-related microarray from the GEO database, and OS-genes were extracted from GeneCards database. The intersection of the OS-genes and the DEGs was considered as oxidative stress-related DEGs (OS-DEGs) in periodontitis. The Pearson correlation and protein-protein interaction analyses were used to screen key OS-genes. Gene set enrichment, functional enrichment, and pathway enrichment analyses were performed in OS-genes. Based on key OS-genes, a risk score model was constructed through logistic regression, receiver operating characteristic curve, and stratified analyses. Results: In total, 74 OS-DEGs were found in periodontitis, including 65 upregulated genes and 9 downregulated genes. Six of them were identified as key OS-genes (CXCR4, SELL, FCGR3B, FCGR2B, PECAM1, and ITGAL) in periodontitis. All the key OS-genes were significantly upregulated and associated with the increased risk of periodontitis. Functional enrichment analysis showed that these genes were mainly associated with leukocyte cell-cell adhesion, phagocytosis, and cellular extravasation. Pathway analysis revealed that these genes were involved in several signaling pathways, such as leukocyte transendothelial migration and osteoclast differentiation. Conclusion: In this study, we screened six key OS-genes that were screened as risk factors of periodontitis. We also identified multiple signaling pathways that might play crucial roles in regulating oxidative stress damage in periodontitis. In the future, more experiments need to be carried out to validate our current findings.


Assuntos
Perfilação da Expressão Gênica , Periodontite , Biologia Computacional , Humanos , Análise em Microsséries , Estresse Oxidativo/genética , Periodontite/genética
12.
Medicina (Kaunas) ; 58(9)2022 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-36143891

RESUMO

Oral manifestations are early and important clinical indicators of Human Immunodeficiency Virus (HIV) infection since they can occur in up to 50% of HIV-infected patients and in up to 80% of patients at the AIDS stage (<200 CD4+ T lymphocytes). Oral health is related to physical and mental well-being because the presence of some lesions can compromise dental aesthetics, and alter speech, chewing, and swallowing, thus impacting the quality of life of patients. For this reason, it is necessary to integrate, as part of the medical treatment of HIV-positive patients, the prevention, diagnosis, and control of oral health. It is essential that health professionals have the power to identify, diagnose, and treat oral pathologies through clinical characteristics, etiological agents, and risk factors, both local and systemic. A diagnosis at an early stage of injury allows optimizing and prioritizing oral treatments, especially in acute pathologies, such as gingivitis and necrotizing periodontitis. In this group of patients, the development of strategies for the prevention, control, and reduction of these pathologies must be prioritized in order to reduce morbidity and mortality in this group of patients.


Assuntos
Infecções por HIV , Periodontite , Infecções por HIV/complicações , Infecções por HIV/diagnóstico , Humanos , Contagem de Linfócitos , Saúde Bucal , Periodontite/complicações , Qualidade de Vida
13.
Nutrients ; 14(18)2022 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-36145111

RESUMO

The association between periodontitis and lifestyle factors has been widely investigated. However, an association between periodontitis and dietary patterns has not been explored. Therefore, this study investigated the association between periodontitis and food consumption among a Southern Brazil population. Data from the 1982 Pelotas Birth Cohort were used (n = 537). The exposure, periodontitis, was clinically measured and classified using the AAP/CDC system, then two latent variables were defined: 'initial' and 'moderate/severe' periodontitis. The consumption of in natura, processed, and ultra-processed foods (NOVA classification) was the outcome and measured in calories using the food frequency questionnaire (FFQ). Confounders were sex, maternal education, smoking status, xerostomia, and halitosis. Data were analyzed by structural equation modeling. 'Initial' periodontitis was associated with a higher consumption of in natura food (standardized coefficient (SC) 0.102; p-value = 0.040), versus processed (SC 0.078; p-value = 0.129) and ultra-processed (SC 0.043; p-value = 0.400) foods. 'Moderate/severe' periodontitis was associated with higher consumption of ultra-processed foods (SC 0.108; p-value = 0.024), versus processed (SC 0.093; p-value = 0.053) and in natura (SC 0.014; p-value = 0.762) foods. 'Moderate/severe' periodontitis appears to be associated with the consumption of processed and ultra-processed foods.


Assuntos
Fast Foods , Periodontite , Brasil/epidemiologia , Dieta/efeitos adversos , Ingestão de Energia , Fast Foods/efeitos adversos , Manipulação de Alimentos , Humanos , Periodontite/epidemiologia , Periodontite/etiologia
14.
Commun Biol ; 5(1): 962, 2022 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-36104423

RESUMO

Periodontitis is a highly prevalent disease leading to uncontrolled osteoclastic jawbone resorption and ultimately edentulism; however, the disease onset mechanism has not been fully elucidated. Here we propose a mechanism for initial pathology based on results obtained using a recently developed Osteoadsorptive Fluogenic Sentinel (OFS) probe that emits a fluorescent signal triggered by cathepsin K (Ctsk) activity. In a ligature-induced mouse model of periodontitis, a strong OFS signal is observed before the establishment of chronic inflammation and bone resorption. Single cell RNA sequencing shows gingival fibroblasts to be the primary cellular source of early Ctsk. The in vivo OFS signal is activated when Toll-Like Receptor 9 (TLR9) ligand or oral biofilm extracellular DNA (eDNA) is topically applied to the mouse palatal gingiva. This previously unrecognized interaction between oral microbial eDNA and Ctsk of gingival fibroblasts provides a pathological mechanism for disease initiation and a strategic basis for early diagnosis and treatment of periodontitis.


Assuntos
Reabsorção Óssea , Periodontite , Animais , Reabsorção Óssea/metabolismo , Catepsina K/genética , Catepsina K/metabolismo , Catepsina K/farmacologia , DNA/metabolismo , Fibroblastos/metabolismo , Gengiva/metabolismo , Gengiva/patologia , Camundongos , Periodontite/genética , Periodontite/metabolismo , Periodontite/patologia
16.
Cell Rep ; 40(12): 111389, 2022 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-36130514

RESUMO

Periodontal disease (PD) is one of the most common inflammatory diseases in humans and is initiated by an oral microbial dysbiosis that stimulates inflammation and bone loss. Here, we report an abnormal elevation of succinate in the subgingival plaque of subjects with severe PD. Succinate activates succinate receptor-1 (SUCNR1) and stimulates inflammation. We detected SUCNR1 expression in the human and mouse periodontium and hypothesize that succinate activates SUCNR1 to accelerate periodontitis through the inflammatory response. Administration of exogenous succinate enhanced periodontal disease, whereas SUCNR1 knockout mice were protected from inflammation, oral dysbiosis, and subsequent periodontal bone loss in two different models of periodontitis. Therapeutic studies demonstrated that a SUCNR1 antagonist inhibited inflammatory events and osteoclastogenesis in vitro and reduced periodontal bone loss in vivo. Our study reveals succinate's effect on periodontitis pathogenesis and provides a topical treatment for this disease.


Assuntos
Perda do Osso Alveolar , Doenças Periodontais , Periodontite , Perda do Osso Alveolar/tratamento farmacológico , Animais , Disbiose , Humanos , Inflamação/metabolismo , Camundongos , Camundongos Knockout , Periodontite/tratamento farmacológico , Ácido Succínico/metabolismo
17.
Front Biosci (Elite Ed) ; 14(3): 19, 2022 07 27.
Artigo em Inglês | MEDLINE | ID: mdl-36137992

RESUMO

Orthodontic treatment has become increasingly popular due to its benefits in improving facial and smile aesthetics, self-esteem and the function of the stomatognathic apparatus. However, orthodontic appliances make it more difficult to brush teeth effectively, as they interfere with tooth brushing and facilitate the accumulation of dental plaque (biofilm), which induces a quantitative and qualitative change in the oral microbiota. It can cause several adverse effects, such as gingivitis, periodontitis, white spot lesions (WSL), caries and halitosis, induced by an increase in periodontopathogenic and cariogenic bacteria. Therefore, this article resumes the main findings on the changes in the oral microbiota induced by different orthodontic appliances (removable, fixed and clear aligners) and gives some practical strategies in order to reduce the impact and/or incidence of local dental/periodontal complications.


Assuntos
Gengivite , Microbiota , Periodontite , Biofilmes , Gengivite/microbiologia , Humanos , Aparelhos Ortodônticos/efeitos adversos , Periodontite/terapia
18.
Artigo em Inglês | MEDLINE | ID: mdl-36141573

RESUMO

Psoriasis is a chronic, inflammatory, and recurrent skin disease. As with periodontitis, the development and progression of lesions depend on immunological, genetic, and environmental factors. This systematic review was designed to answer the question: "Is there a relationship between psoriasis and periodontal disease?". Following the inclusion and exclusion criteria, sixteen studies were included in this systematic review (according to PRISMA statement guidelines). Based on the meta-analysis, psoriasis patients showed a more than two-fold increase in the odds of periodontal disease. Almost one-third of these patients suffered from periodontitis of varying severity. Despite the heterogeneity of the included studies, psoriasis is associated with a higher risk of periodontitis, and especially with advanced progression.


Assuntos
Doenças Periodontais , Periodontite , Psoríase , Humanos , Doenças Periodontais/complicações , Doenças Periodontais/epidemiologia , Periodontite/complicações , Psoríase/complicações , Psoríase/epidemiologia
19.
Artigo em Inglês | MEDLINE | ID: mdl-36141577

RESUMO

Halitosis, or bad breath, is an oral health problem characterized by an unpleasant malodor emanating from the oral cavity. This condition can have different origins and causes a negative burden in social interactions, communication and quality of life, and can in uncommon cases be indicative of underlying non-oral non-communicable diseases. Most cases of halitosis are due to inadequate oral hygiene, periodontitis and tongue coating, yet the remaining proportion of cases are due to ear-nose-throat-associated (10%) or gastrointestinal/endocrine (5%) disorders. For this reason, the diagnosis, treatment and clinical management of halitosis often require a multidisciplinary team approach. This comprehensive review revisits the etiology of halitosis as well as standard and novel treatment that may contribute to higher clinical success.


Assuntos
Halitose , Periodontite , Halitose/etiologia , Halitose/terapia , Humanos , Saúde Bucal , Higiene Bucal , Periodontite/complicações , Periodontite/terapia , Qualidade de Vida , Língua
20.
Br Dent J ; 233(6): 494, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36151179
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