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1.
FASEB J ; 38(11): e23719, 2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38837828

RESUMO

Chronic disruption of circadian rhythms by night shift work is associated with an increased breast cancer risk. However, little is known about the impact of night shift on peripheral circadian genes (CGs) and circadian-controlled genes (CCGs) associated with breast cancer. Hence, we assessed central clock markers (melatonin and cortisol) in plasma, and peripheral CGs (PER1, PER2, PER3, and BMAL1) and CCGs (ESR1 and ESR2) in peripheral blood mononuclear cells (PBMCs). In day shift nurses (n = 12), 24-h rhythms of cortisol and melatonin were aligned with day shift-oriented light/dark schedules. The mRNA expression of PER2, PER3, BMAL1, and ESR2 showed 24-h rhythms with peak values in the morning. In contrast, night shift nurses (n = 10) lost 24-h rhythmicity of cortisol with a suppressed morning surge but retained normal rhythmic patterns of melatonin, leading to misalignment between cortisol and melatonin. Moreover, night shift nurses showed disruption of rhythmic expressions of PER2, PER3, BMAL1, and ESR2 genes, resulting in an impaired inverse correlation between PER2 and BMAL1 compared to day shift nurses. The observed trends of disrupted circadian markers were recapitulated in additional day (n = 20) and night (n = 19) shift nurses by measurement at early night and midnight time points. Taken together, this study demonstrated the misalignment of cortisol and melatonin, associated disruption of PER2 and ESR2 circadian expressions, and internal misalignment in peripheral circadian network in night shift nurses. Morning plasma cortisol and PER2, BMAL1, and ESR2 expressions in PBMCs may therefore be useful biomarkers of circadian disruption in shift workers.


Assuntos
Relógios Circadianos , Ritmo Circadiano , Hidrocortisona , Melatonina , Jornada de Trabalho em Turnos , Humanos , Feminino , Melatonina/metabolismo , Melatonina/sangue , Adulto , Jornada de Trabalho em Turnos/efeitos adversos , Relógios Circadianos/genética , Hidrocortisona/sangue , Hidrocortisona/metabolismo , Ritmo Circadiano/fisiologia , Proteínas Circadianas Period/genética , Proteínas Circadianas Period/metabolismo , Enfermeiras e Enfermeiros , Leucócitos Mononucleares/metabolismo , Receptor alfa de Estrogênio/metabolismo , Receptor alfa de Estrogênio/genética , Receptor beta de Estrogênio/metabolismo , Receptor beta de Estrogênio/genética , Fatores de Transcrição ARNTL/genética , Fatores de Transcrição ARNTL/metabolismo , Tolerância ao Trabalho Programado/fisiologia , Condições de Trabalho
2.
J Med Internet Res ; 26: e50149, 2024 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-38838328

RESUMO

BACKGROUND: This study aimed to investigate the relationships between adiposity and circadian rhythm and compare the measurement of circadian rhythm using both actigraphy and a smartphone app that tracks human-smartphone interactions. OBJECTIVE: We hypothesized that the app-based measurement may provide more comprehensive information, including light-sensitive melatonin secretion and social rhythm, and have stronger correlations with adiposity indicators. METHODS: We enrolled a total of 78 participants (mean age 41.5, SD 9.9 years; 46/78, 59% women) from both an obesity outpatient clinic and a workplace health promotion program. All participants (n=29 with obesity, n=16 overweight, and n=33 controls) were required to wear a wrist actigraphy device and install the Rhythm app for a minimum of 4 weeks, contributing to a total of 2182 person-days of data collection. The Rhythm app estimates sleep and circadian rhythm indicators by tracking human-smartphone interactions, which correspond to actigraphy. We examined the correlations between adiposity indices and sleep and circadian rhythm indicators, including sleep time, chronotype, and regularity of circadian rhythm, while controlling for physical activity level, age, and gender. RESULTS: Sleep onset and wake time measurements did not differ significantly between the app and actigraphy; however, wake after sleep onset was longer (13.5, SD 19.5 minutes) with the app, resulting in a longer actigraphy-measured total sleep time (TST) of 20.2 (SD 66.7) minutes. The obesity group had a significantly longer TST with both methods. App-measured circadian rhythm indicators were significantly lower than their actigraphy-measured counterparts. The obesity group had significantly lower interdaily stability (IS) than the control group with both methods. The multivariable-adjusted model revealed a negative correlation between BMI and app-measured IS (P=.007). Body fat percentage (BF%) and visceral adipose tissue area (VAT) showed significant correlations with both app-measured IS and actigraphy-measured IS. The app-measured midpoint of sleep showed a positive correlation with both BF% and VAT. Actigraphy-measured TST exhibited a positive correlation with BMI, VAT, and BF%, while no significant correlation was found between app-measured TST and either BMI, VAT, or BF%. CONCLUSIONS: Our findings suggest that IS is strongly correlated with various adiposity indicators. Further exploration of the role of circadian rhythm, particularly measured through human-smartphone interactions, in obesity prevention could be warranted.


Assuntos
Actigrafia , Adiposidade , Algoritmos , Ritmo Circadiano , Smartphone , Humanos , Feminino , Actigrafia/instrumentação , Actigrafia/métodos , Masculino , Adulto , Ritmo Circadiano/fisiologia , Pessoa de Meia-Idade , Obesidade/fisiopatologia , Aplicativos Móveis , Sono/fisiologia
4.
Anat Histol Embryol ; 53(4): e13071, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38868938

RESUMO

The pecten is a fold-structured projection at the ocular fundus in bird eyes, showing morphological diversity between the diurnal and nocturnal species. However, its biological functions remain unclear. This study investigated the morphological and histological characteristics of pectens in wild birds. Additionally, the expression of non-visual opsin genes was studied in chicken pectens. These genes, identified in the chicken retina and brain, perceive light periodicity regardless of visual communication. Similar pleat numbers have been detected among bird taxa; however, pecten size ratios in the ocular fundus showed noticeable differences between diurnal and nocturnal birds. The pectens in nocturnal brown hawk owl show extremely poor vessel distribution and diameters compared with that of diurnal species. RT-PCR analysis confirmed the expression of Opn5L3, Opn4x, Rrh and Rgr genes. In situ hybridization analysis revealed the distribution of Rgr-positive reactions in non-melanotic cells around the pecten vessels. This study suggests a novel hypothesis that pectens develop dominantly in diurnal birds as light acceptors and contribute to continuous visual function or the onset of periodic behaviour.


Assuntos
Hibridização In Situ , Opsinas , Retina , Animais , Opsinas/genética , Opsinas/metabolismo , Retina/fisiologia , Galinhas/fisiologia , Galinhas/genética , Aves/fisiologia , Ritmo Circadiano/fisiologia , Encéfalo/metabolismo
5.
Psychiatry Res ; 338: 115976, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38830322

RESUMO

Despite many available treatment options for depression, response rates remain suboptimal. To improve outcome, circadian markers may be suitable as markers of treatment response. This systematic review provides an overview of circadian markers that have been studied as predictors of response in treatment of depression. A search was performed (EMBASE, PUBMED, PSYCHINFO) for research studies or articles, randomized controlled trials and case report/series with no time boundaries on March 2, 2024 (PROSPERO: CRD42021252333). Other criteria were; an antidepressant treatment as intervention, treatment response measured by depression symptom severity and/or occurrence of a clinical diagnosis of depression and assessment of a circadian marker at baseline. 44 articles, encompassing 8,772 participants were included in the analysis. Although additional research is needed with less variation in types of markers and treatments to provide definitive recommendations, circadian markers, especially diurnal mood variation and chronotype, show potential to implement as response markers in the clinic.


Assuntos
Antidepressivos , Ritmo Circadiano , Humanos , Ritmo Circadiano/fisiologia , Antidepressivos/uso terapêutico , Depressão/tratamento farmacológico , Biomarcadores
6.
Psychiatry Res ; 338: 116006, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38850890

RESUMO

Anxiety symptoms vary moment-to-moment within a day. One factor that may influence these variations is chronotype. Evening chronotypes prefer to engage in activities (e.g., sleep, physical and social activity) later in the day, and evening chronotype is implicated in psychopathology, including anxiety-related disorders. However, it is unknown whether chronotype influences diurnal variation in anxiety symptoms and whether these effects are amplified in individuals with a probable anxiety-related disorder. We examined the diurnal variation in anxiety symptoms and daily activities in morning and evening chronotypes with and without probable generalized anxiety disorder (GAD) or obsessive-compulsive disorder (OCD) in a community sample of adults (N = 410). Evening chronotypes reported higher anxiety symptoms, particularly in the evening hours, and lower engagement in daily activities, predominantly in the morning hours. Evening chronotypes with probable GAD or OCD reported worse anxiety symptoms in the evening. Our findings indicate that anxiety symptoms and engagement in daily activities fluctuate considerably across the day, and these patterns differ depending on chronotype. Evening chronotypes have more anxiety symptoms in the evening, despite preferring this time of day. Personalized treatment approaches that consider chronotype and target certain times of day may be efficient in alleviating peaks in anxiety symptoms.


Assuntos
Transtornos de Ansiedade , Ansiedade , Ritmo Circadiano , Humanos , Masculino , Feminino , Adulto , Ritmo Circadiano/fisiologia , Transtornos de Ansiedade/fisiopatologia , Transtornos de Ansiedade/epidemiologia , Transtornos de Ansiedade/psicologia , Ansiedade/fisiopatologia , Pessoa de Meia-Idade , Transtorno Obsessivo-Compulsivo/fisiopatologia , Adulto Jovem , Sono/fisiologia , Atividades Cotidianas , Adolescente , Cronotipo
7.
Sci Rep ; 14(1): 13509, 2024 06 12.
Artigo em Inglês | MEDLINE | ID: mdl-38866912

RESUMO

Proper alignment of activity-rest and light-dark patterns allows for healthy bodily functions to occur at optimal times of the day. Disruptions to this alignment may cause poor sleep as well as physical, mental, and cognitive problems. The purpose of this cross-sectional study was to determine if poorer circadian alignment was associated with decreased cognitive functioning among older (> 60 years) participants in the National Health and Nutrition Examination Survey. We utilized actigraphy-based rest-activity and dark-light measurements to calculate phasor magnitude (strength of circadian alignment coupling) and phasor angle (phase difference between activity-rest and light-dark cycles). Multiple linear regression models were used to determine associations of phasor magnitude and angle with performance in various cognitive tests, including Digit Symbol Substitution Test score (DSSS), CERAD Savings Percentage (CSP), and Animal Fluency Test (AFT) score. The results showed that a lower phasor magnitude (which indicates decreased strength of alignment coupling between rest-activity and dark-light cycles) was significantly associated with decreased DSSS (indicating slower processing speed and poorer working memory) when controlling for many important sociodemographic factors. However, this association became non-significant when accounting for sleep duration and total physical activity. Phasor angle did not have a significant association with any of the cognitive scores. Overall, we provided evidence indicating that circadian alignment may be a predictor of cognitive performance. Future studies should investigate whether improving circadian alignment may improve cognitive function and prevent cognitive decline.


Assuntos
Ritmo Circadiano , Cognição , Humanos , Feminino , Masculino , Idoso , Ritmo Circadiano/fisiologia , Cognição/fisiologia , Estudos Transversais , Pessoa de Meia-Idade , Actigrafia , Idoso de 80 Anos ou mais , Sono/fisiologia , Inquéritos Nutricionais
8.
Transl Psychiatry ; 14(1): 237, 2024 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-38834543

RESUMO

To advance the emergence of circadian-based therapies, this study characterized how psychiatric symptoms fluctuate across the day and vary between individuals. Using a dimensional approach, we determined how chronotype relates to 13 psychiatric traits, and modeled the temporal development of symptoms throughout the day using generalized additive mixed effects models. In this preregistered study, a subclinical sample completed 13 psychiatric trait scales and a chronotype scale at baseline (N = 515, n = 404 women, 109 men, n = 2 non-binary, M age = 32.4 years, range 18-77), followed by 22 psychiatric symptoms and behaviors rated repeatedly between ~08:00-00:00 (n = 410). Key findings are that 11 out of 13 psychiatric traits were associated with being an evening-type, ranging from depression to obsessive comulsive disorder, social anxiety, and delusional ideation, while only mania was associated with being a morning-type. Four distinct psychiatric trait factors were identified, each predicting worse symptom levels throughout the day. Fatigue-related symptoms exhibited strong time-of-day changes with evening-types experiencing worse fatigue in the morning and morning-types in the evening. Evening-types had considerably lower drive and motivation than morning-types from morning to early evening. Evening-types also had more pronounced negative emotional symptoms and ADHD-type symptoms in the evening, particularly among those high in psychiatric trait factors. These findings identified important research targets that hold promise for improving mental health outcomes, such as strategies to boost morning motivation. Furthermore, the results emphasize the relevance of incorporating circadian factors, including chronotype, into translational psychiatric research and interventions.


Assuntos
Ritmo Circadiano , Humanos , Masculino , Feminino , Adulto , Ritmo Circadiano/fisiologia , Pessoa de Meia-Idade , Adolescente , Adulto Jovem , Idoso , Transtornos Mentais/psicologia , Transtornos Mentais/fisiopatologia , Saúde Mental , Escalas de Graduação Psiquiátrica , Cronotipo
10.
Front Endocrinol (Lausanne) ; 15: 1397062, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38836224

RESUMO

Background and aims: A prothrombotic state was demonstrated in patients with Cushing's syndrome and is involved in the development and progression of cardiovascular and renal damage in hypertensive patients. This study was designed to examine the relationships between cortisol secretion and the hemostatic and fibrinolytic systems in hypertension. Methods: In 149 middle-aged, nondiabetic, essential hypertensive patients free of cardiovascular and renal complications, we measured hemostatic markers that express the spontaneous activation of the coagulation and fibrinolytic systems and assessed daily cortisol levels (8 AM, 3 PM, 12 AM; area under the curve, AUC-cortisol) together with the cortisol response to dexamethasone overnight suppression (DST-cortisol). Results: Plasma levels of D-dimer (D-dim), prothrombin fragment 1 + 2 (F1 + 2), and von Willebrand factor (vWF) were progressively and significantly higher across tertiles of AUC-cortisol and DST-cortisol, whereas no differences were observed in fibrinogen, tissue plasminogen activator, plasminogen activator inhibitor-1, antithrombin III, protein C, and protein S. D-dim, F1 + 2, and vWF were significantly and directly correlated with age and both AUC-cortisol and DST-cortisol. Multivariate regression analysis showed that both AUC-cortisol and DST-cortisol were related to plasma D-dim, F1 + 2, and vWF independently of age, body mass index, blood pressure, and renal function. Conclusion: Greater daily cortisol profile and cortisol response to overnight suppression are independently associated with a prothrombotic state in hypertensive patients and might contribute to the development of organ damage and higher risk of cardiovascular complications.


Assuntos
Dexametasona , Hidrocortisona , Hipertensão , Humanos , Masculino , Pessoa de Meia-Idade , Feminino , Hidrocortisona/sangue , Hipertensão/sangue , Hipertensão/complicações , Adulto , Trombose/sangue , Trombose/etiologia , Fator de von Willebrand/metabolismo , Fator de von Willebrand/análise , Ritmo Circadiano/fisiologia , Idoso , Biomarcadores/sangue
11.
BMJ Open ; 14(6): e086801, 2024 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-38830738

RESUMO

INTRODUCTION: One in five Canadians lives with chronic pain. Evidence shows that some individuals experience pain that fluctuates in intensity following a circadian (24-hour) rhythm. Endogenous molecular rhythms regulate the function of physiological processes that govern pain mechanisms. Addressing chronic pain rhythmicity on a molecular and biopsychosocial level can advance understanding of the disease and identify new treatment/management strategies. Our CircaHealth CircaPain study uses an online survey combined with ecological momentary assessments and biosample collection to investigate the circadian control of chronic pain and identify potential biomarkers. Our primary objective is to understand interindividual variability in pain rhythmicity, by collecting biopsychosocial measures. The secondary objective accounts for seasonal variability and the effect of latitude on rhythmicity. METHODS AND ANALYSIS: Following completion of a baseline questionnaire, participants complete a series of electronic symptom-tracking diaries to rate their pain intensity, negative affect, fatigue and stress on a 0-10 scale at 8:00, 14:00 and 20:00 daily over 10 days. These measures are repeated at 6 and 12 months postenrolment to account for potential seasonal changes. We aim to recruit ≥2500 adults with chronic pain within Canada. Infrastructure is being developed to facilitate the collection of blood samples from subgroups of participants (~800) two times per day over 24-48 hours to identify rhythmic expression of circulating genes and/or proteins. ETHICS AND DISSEMINATION: Ethical approval for this study was obtained by the Queen's University Health Sciences and Affiliated Teaching Hospitals Research Ethics Board (File No. 6038114). Participants provide informed consent to participate, and their data will not be identifiable in any publication or report. Findings will be published in a relevant scientific journal and disseminated at scientific meetings and online webinars. We maintain a website to post updated resources and engage with the community. We employ knowledge mobilisation in the form of direct data sharing with participants.


Assuntos
Dor Crônica , Humanos , Canadá , Estudos Longitudinais , Ritmo Circadiano/fisiologia , Adulto , Inquéritos e Questionários , Avaliação Momentânea Ecológica , Feminino , Masculino , Biomarcadores/sangue , Estações do Ano , Medição da Dor , Fadiga
13.
Chronobiol Int ; 41(6): 904-923, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38832541

RESUMO

Chrononutrition, an emerging body of evidence on the relationship between biological rhythms and metabolism, has been established to be associated with glycemic responses. However, the available evidence is inconsistent, due to protocol variations. Therefore, this review aims to summarize the findings on chrononutrition characteristics and their association with glycemic responses among adults. Systematic searches were conducted across six databases (PubMed, EBSCO Host, ProQuest Central, MEDLINE & Ovid, Scopus and Web of Science) to identify all relevant studies published from January 2012. Two reviewers independently screened the abstracts and full-text articles based on the inclusion and exclusion criteria. Details about population characteristics, study methods and key findings were extracted following the PRISMA-ScR guideline. The quality of selected studies was evaluated using the mixed methods appraisal tool. The searchers identified 49 studies eligible for analysis. The results showed that meal timing, particularly night-time eating and snacking were associated with glycemic responses. Regarding meal regularity, skipping breakfast may affect glycemic responses, but no clear conclusion was drawn about its effect on insulin. The association between meal frequency and glycemic responses was inconclusive. Night fasting duration and restricted eating window are potentially associated with glycemic responses. The current review extensively investigates the association between chrononutrition factors and glycemic responses in adults. However, more prospective cohort and interventional studies are needed to better understand this causal-effect relationship.


Assuntos
Glicemia , Ritmo Circadiano , Humanos , Glicemia/metabolismo , Adulto , Ritmo Circadiano/fisiologia , Comportamento Alimentar/fisiologia , Refeições/fisiologia , Insulina/sangue , Insulina/metabolismo , Fatores de Tempo , Jejum/fisiologia
14.
Chronobiol Int ; 41(6): 888-903, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38832548

RESUMO

This review highlights recent findings on biological rhythms and discusses their implications for the management and production of domestic animals. Biological rhythms provide temporal coordination between organs and tissues in order to anticipate environmental changes, orchestrating biochemical, physiological and behavioural processes as the right process may occur at the right time. This allows animals to adapt their internal physiological functions, such as sleep-wake cycles, body temperature, hormone secretion, food intake and regulation of physical performance to environmental stimuli that constantly change. The study and evaluation of biological rhythms of various physiological parameters allows the assessment of the welfare status of animals. Alteration of biological rhythms represents an imbalance of the state of homeostasis that can be found in different management conditions.


Assuntos
Animais Domésticos , Ritmo Circadiano , Animais , Ritmo Circadiano/fisiologia , Animais Domésticos/fisiologia , Sono/fisiologia , Temperatura Corporal/fisiologia , Comportamento Animal/fisiologia
15.
Chronobiol Int ; 41(6): 924-928, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38836459

RESUMO

In the current study, we examined the association between eveningness and testosterone levels in men. Specifically, we differentiated between free and total testosterone fractions, with free testosterone being recognized as the most bioavailable form of this hormone. We collected blood samples from 298 men aged 18-44 to assess total and free testosterone. Additionally, we measured sleep timing variables using the Munich Chronotype Questionnaire. The main result of the current study indicated that evening chronotype was associated with higher levels of free testosterone, but was unrelated to total testosterone. Sleep loss was unrelated to the both testosterone fractions. We expanded prior findings by utilizing a more comprehensive testosterone assay what indicated that evening chronotype is primarily associated with the most bioavailable form of testosterone (i.e. free testosterone) in adult men.


Assuntos
Ritmo Circadiano , Sono , Testosterona , Humanos , Masculino , Testosterona/sangue , Adulto , Ritmo Circadiano/fisiologia , Adulto Jovem , Sono/fisiologia , Adolescente , Inquéritos e Questionários , Fatores de Tempo , Cronotipo
16.
BMC Med Res Methodol ; 24(1): 132, 2024 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-38849718

RESUMO

Accelerometers, devices that measure body movements, have become valuable tools for studying the fragmentation of rest-activity patterns, a core circadian rhythm dimension, using metrics such as inter-daily stability (IS), intradaily variability (IV), transition probability (TP), and self-similarity parameter (named α ). However, their use remains mainly empirical. Therefore, we investigated the mathematical properties and interpretability of rest-activity fragmentation metrics by providing mathematical proofs for the ranges of IS and IV, proposing maximum likelihood and Bayesian estimators for TP, introducing the activity balance index (ABI) metric, a transformation of α , and describing distributions of these metrics in real-life setting. Analysis of accelerometer data from 2,859 individuals (age=60-83 years, 21.1% women) from the Whitehall II cohort (UK) shows modest correlations between the metrics, except for ABI and α . Sociodemographic (age, sex, education, employment status) and clinical (body mass index (BMI), and number of morbidities) factors were associated with these metrics, with differences observed according to metrics. For example, a difference of 5 units in BMI was associated with all metrics (differences ranging between -0.261 (95% CI -0.302, -0.220) to 0.228 (0.18, 0.268) for standardised TP rest to activity during the awake period and TP activity to rest during the awake period, respectively). These results reinforce the value of these rest-activity fragmentation metrics in epidemiological and clinical studies to examine their role for health. This paper expands on a set of methods that have previously demonstrated empirical value, improves the theoretical foundation for these methods, and evaluates their empirical use in a large dataset.


Assuntos
Acelerometria , Descanso , Humanos , Feminino , Idoso , Masculino , Acelerometria/métodos , Acelerometria/estatística & dados numéricos , Pessoa de Meia-Idade , Descanso/fisiologia , Idoso de 80 Anos ou mais , Teorema de Bayes , Índice de Massa Corporal , Ritmo Circadiano/fisiologia , Funções Verossimilhança , Atividade Motora/fisiologia
17.
Front Endocrinol (Lausanne) ; 15: 1320605, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38872971

RESUMO

Due to the Earth's rotation, the natural environment exhibits a light-dark diurnal cycle close to 24 hours. To adapt to this energy intake pattern, organisms have developed a 24-hour rhythmic diurnal cycle over long periods, known as the circadian rhythm, or biological clock. With the gradual advancement of research on the biological clock, it has become increasingly evident that disruptions in the circadian rhythm are closely associated with the occurrence of type 2 diabetes (T2D). To further understand the progress of research on T2D and the biological clock, this paper reviews the correlation between the biological clock and glucose metabolism and analyzes its potential mechanisms. Based on this, we discuss the potential factors contributing to circadian rhythm disruption and their impact on the risk of developing T2D, aiming to explore new possible intervention measures for the prevention and treatment of T2D in the future. Under the light-dark circadian rhythm, in order to adapt to this change, the human body forms an internal biological clock involving a variety of genes, proteins and other molecules. The main mechanism is the transcription-translation feedback loop centered on the CLOCK/BMAL1 heterodimer. The expression of important circadian clock genes that constitute this loop can regulate T2DM-related blood glucose traits such as glucose uptake, fat metabolism, insulin secretion/glucagon secretion and sensitivity in various peripheral tissues and organs. In addition, sleep, light, and dietary factors under circadian rhythms also affect the occurrence of T2DM.


Assuntos
Ritmo Circadiano , Diabetes Mellitus Tipo 2 , Diabetes Mellitus Tipo 2/metabolismo , Humanos , Ritmo Circadiano/fisiologia , Animais , Relógios Biológicos , Relógios Circadianos/fisiologia , Glicemia/metabolismo
18.
Dent Clin North Am ; 68(3): 467-474, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38879280

RESUMO

Biologic synchronized rhythmicity is a critical physiologic process. The lack of synchronized rhythms, mainly those showing a circadian basis, like sleep, heart rate, and arterial pressure, often leads to several organic challenges usually associated with adverse outcomes. Sleep itself, as an independent regulator of many crucial body functions, should preferentially occur with minimum interferences to optimize its plastic role toward structural and functional recovery and regeneration. Hence, patients will mostly benefit from both circadian and sleep-related optimized functions in order to improve prognosis and reduce patients' discharge times.


Assuntos
Ritmo Circadiano , Qualidade do Sono , Humanos , Criança , Ritmo Circadiano/fisiologia , Unidades de Terapia Intensiva Pediátrica , Sono/fisiologia , Cuidados Críticos
19.
Int J Mol Sci ; 25(11)2024 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-38892035

RESUMO

The circadian clock regulates biological cycles across species and is crucial for physiological activities and biochemical reactions, including cancer onset and development. The interplay between the circadian rhythm and cancer involves regulating cell division, DNA repair, immune function, hormonal balance, and the potential for chronotherapy. This highlights the importance of maintaining a healthy circadian rhythm for cancer prevention and treatment. This article investigates the complex relationship between the circadian rhythm and cancer, exploring how disruptions to the internal clock may contribute to tumorigenesis and influence cancer progression. Numerous databases are utilized to conduct searches for articles, such as NCBI, MEDLINE, and Scopus. The keywords used throughout the academic archives are "circadian rhythm", "cancer", and "circadian clock". Maintaining a healthy circadian cycle involves prioritizing healthy sleep habits and minimizing disruptions, such as consistent sleep schedules, reduced artificial light exposure, and meal timing adjustments. Dysregulation of the circadian clock gene and cell cycle can cause tumor growth, leading to the need to regulate the circadian cycle for better treatment outcomes. The circadian clock components significantly impact cellular responses to DNA damage, influencing cancer development. Understanding the circadian rhythm's role in tumor diseases and their therapeutic targets is essential for treating and preventing cancer. Disruptions to the circadian rhythm can promote abnormal cell development and tumor metastasis, potentially due to immune system imbalances and hormonal fluctuations.


Assuntos
Relógios Circadianos , Ritmo Circadiano , Neoplasias , Humanos , Neoplasias/metabolismo , Neoplasias/patologia , Ritmo Circadiano/fisiologia , Animais
20.
Nutrients ; 16(11)2024 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-38892514

RESUMO

The concept of Circadian Syndrome (CircS) aims to emphasize the circadian disruptions underlying cardiometabolic conditions. Meal timing and shiftwork may disrupt circadian rhythms, increasing cardiometabolic risk. This study aimed to assess the associations of meal timing, meal skipping, and shiftwork with CircS in US adults and explore effect modifications by sociodemographic and lifestyle factors. CircS was defined using Metabolic Syndrome components in addition to short sleep and depression symptoms. Data from 10,486 participants of the National Health and Nutrition Examination Survey 2005-2016 were analyzed cross-sectionally. Mealtime was assessed by calculating the midpoint of intake between breakfast and dinner and dichotomizing it into favorable mealtime (between 12:30 and 13:15) and unfavorable mealtime using a data-driven approach. Meal skippers were categorized separately. Participants working evening, night, or rotating shifts were classified as shift workers. In the multivariable logistic regression analysis, an unfavorable mealtime, meal skipping, and shiftwork were associated with a higher likelihood of CircS (OR = 1.24; 95%CI 1.07-1.44, OR = 1.39; 95%CI 1.16-1.67, and OR = 1.37; 95%CI 1.01-1.87, respectively). Subgroup analyses revealed no significant interactions between meal timing, meal skipping, or shiftwork and socioeconomic status or lifestyle regarding CircS. These findings highlight the importance of aligning mealtimes with circadian rhythms for improved circadian health.


Assuntos
Ritmo Circadiano , Comportamento Alimentar , Refeições , Inquéritos Nutricionais , Jornada de Trabalho em Turnos , Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Estudos Transversais , Ritmo Circadiano/fisiologia , Estados Unidos/epidemiologia , Estilo de Vida , Síndrome Metabólica/epidemiologia , Transtornos Cronobiológicos/epidemiologia , Sono/fisiologia , Fatores de Tempo , Jejum Intermitente
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