Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 46.097
Filtrar
1.
Washington, D.C.; OPS; 2024-06-04. (OPS/IMT/QR/23-0003).
em Espanhol | PAHO-IRIS | ID: phr-60175

RESUMO

La provisión y el acceso a sangre segura para transfusiones están en relación estrecha con la organización y el grado de desarrollo de los servicios de sangre, con la gobernanza y con la participación de la sociedad a través de la donación voluntaria no remunerada. Sin embargo, un aspecto importante al abordar la disponibilidad de sangre es la actitud solidaria de las personas que donan sangre y componentes sanguíneos de manera voluntaria y regular. A pesar del notable aumento de la donación voluntaria de sangre en la región, la donación voluntaria aún se encuentra por debajo del 50% y la disponibilidad de sangre por cada mil habitantes en algunos países está muy por debajo de la demanda estimada. Desde el 2004, la Organización Panamericana de la Salud (OPS) ha recopilado y publicado los indicadores relacionados con el suministro de sangre en los países de América Latina y el Caribe, con el fin de facilitar el seguimiento de los avances en el suministro de sangre en los países de la Región. En el 2014, los países de la Región de las Américas reafirmaron su compromiso con la salud universal a través de la aprobación del Plan de acción para el acceso universal a sangre segura 2014-2019, aprobado por el 53.o Consejo Directivo celebrado en octubre del 2014 (CD53.6). Este plan promovía el acceso universal a sangre segura para transfusiones en la Región a través de donaciones voluntarias no remuneradas, la organización de servicios de sangre y la aplicación de estándares de calidad y seguridad y de acciones de gobernanza. El informe final del plan de acción para el acceso universal a sangre segura evidenció modestos avances obtenidos en su implementación, destacándose la cobertura del 100% de análisis de la sangre que se va a transfundir, lo cual llevó a una reducción muy importante en la posibilidad de transmisión por transfusión del VIH y otras infecciones. Sin embargo, este avance puede haber disminuido la prioridad del tema de la sangre en la agenda de salud pública, dejando rezagadas las demás acciones propuestas en el plan para aumentar la seguridad transfusional. También se demostró que es necesario intensificar la integración del tema de la sangre en programas prioritarios de salud pública a fin de destacar su relevancia en temas como la mortalidad materna, los trasplantes y el control de eventos infecciosos como los relacionados con las hepatitis B y C. Así mismo, se requiere fortalecer las acciones de gobernanza en la vigilancia y la organización eficiente de los servicios de sangre para disminuir la existencia de modelos de servicios dispersos, poco eficientes y con altos costos económicos que contribuyen a mantener bajos niveles de acceso y disponibilidad de sangre y escaso avance en la donación voluntaria no remunerada, entre otras acciones necesarias para la seguridad de la sangre. Los datos presentados en esta publicación permiten monitorizar e informar con indicadores específicos el progreso y las limitaciones en la aplicación del Plan de acción para el acceso universal a sangre segura. Asimismo, se espera que estos datos promuevan el análisis y la evaluación a nivel nacional, subregional, y la toma de decisiones que fortalezcan o modifiquen las estrategias que mejoren la seguridad de la sangre y la accesibilidad a las transfusiones. La información fue proporcionada por las autoridades de los países y corresponde a los años 2018, 2019 y 2020.


Assuntos
Sangue , Serviço de Hemoterapia , Acesso a Medicamentos Essenciais e Tecnologias em Saúde , Doação de Sangue , América , Região do Caribe
2.
Nature ; 629(8010): 174-183, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38693412

RESUMO

Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood1-3. Here, the Molecular Transducers of Physical Activity Consortium4 profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and female Rattus norvegicus over eight weeks of endurance exercise training. The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points. Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues. Temporal multi-omic and multi-tissue analyses revealed expansive biological insights into the adaptive responses to endurance training, including widespread regulation of immune, metabolic, stress response and mitochondrial pathways. Many changes were relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health and tissue injury and recovery. The data and analyses presented in this study will serve as valuable resources for understanding and exploring the multi-tissue molecular effects of endurance training and are provided in a public repository ( https://motrpac-data.org/ ).


Assuntos
Treino Aeróbico , Multiômica , Condicionamento Físico Animal , Resistência Física , Animais , Feminino , Humanos , Masculino , Ratos , Acetilação , Sangue/imunologia , Sangue/metabolismo , Doenças Cardiovasculares/genética , Doenças Cardiovasculares/imunologia , Doenças Cardiovasculares/metabolismo , Bases de Dados Factuais , Epigenoma , Doenças Inflamatórias Intestinais/genética , Doenças Inflamatórias Intestinais/imunologia , Doenças Inflamatórias Intestinais/metabolismo , Internet , Lipidômica , Metaboloma , Mitocôndrias/metabolismo , Hepatopatia Gordurosa não Alcoólica/genética , Hepatopatia Gordurosa não Alcoólica/imunologia , Hepatopatia Gordurosa não Alcoólica/metabolismo , Especificidade de Órgãos/genética , Especificidade de Órgãos/imunologia , Especificidade de Órgãos/fisiologia , Fosforilação , Condicionamento Físico Animal/fisiologia , Resistência Física/genética , Resistência Física/fisiologia , Proteoma/metabolismo , Proteômica , Fatores de Tempo , Transcriptoma/genética , Ubiquitinação , Ferimentos e Lesões/genética , Ferimentos e Lesões/imunologia , Ferimentos e Lesões/metabolismo
3.
Soft Matter ; 20(23): 4561-4566, 2024 Jun 12.
Artigo em Inglês | MEDLINE | ID: mdl-38775063

RESUMO

Blood is a highly complex fluid with rheological properties that have a significant impact on various flow phenomena. In particular, it exhibits a non-Newtonian elongational viscosity that is comparable to polymer solutions. In this study, we investigate the effect of three different anticoagulants, namely EDTA (ethylene diamine tetraacetic acid), heparin, and citrate, on the elongational properties of both human and swine blood. We observe a unique two stage thinning process and a strong dependency of the characteristic relaxation time on the chosen anticoagulant, with the longest relaxation time and thus the highest elongational viscosity being found for the case of citrate. Our findings for the latter are consistent with the physiological values obtained from a dripping droplet of human blood without any anticoagulant. Furthermore, our study resolves the discrepancy found in the literature regarding the reported range of characteristic relaxation times, confirming that the elongational viscosity must be taken into account for a full rheological characterization of blood. These results have important implications for understanding blood flow in various physiological, pathological and technological conditions.


Assuntos
Anticoagulantes , Anticoagulantes/farmacologia , Anticoagulantes/química , Humanos , Suínos , Animais , Viscosidade Sanguínea/efeitos dos fármacos , Ácido Edético/química , Ácido Edético/farmacologia , Heparina/farmacologia , Heparina/química , Viscosidade , Ácido Cítrico/química , Sangue/efeitos dos fármacos , Reologia
4.
An Acad Bras Cienc ; 96(2): e20231168, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38808880

RESUMO

The present study aimed to suggest the replacement of animal blood with human blood in culture media, involving alternative methods and ethical considerations, such as animal welfare, in addition to potential laboratory cost reduction. Characteristics of growth and hemolysis development were compared in different culture media, using both sheep blood and human blood. Blood types from the ABO blood group system were tested, and commercially acquired sheep blood agar was used for comparison. Bacteria of the genus Streptococcus spp., Staphylococcus aureus, Enterococcus faecalis, and Escherichia coli were tested. It was observed that growth in media with type A and O positive blood showed closer similarities to those performed in agar with sheep blood. Depending on the bacterial species, the results were either more positive or not, with faster-growing and less demanding bacteria showing better results than, for example, S. pneumoniae, which demonstrated difficulty in the growth process and hemolysis generation in human blood agar. The research suggests that in some situations, sheep blood could be replaced, especially when the goal is growth and isolation, but may not be as suitable when the objective is to analyze hemolysis or when the studied species is demanding.


Assuntos
Meios de Cultura , Humanos , Animais , Ovinos , Estudos de Viabilidade , Staphylococcus aureus/isolamento & purificação , Sangue/microbiologia , Hemólise , Escherichia coli
5.
Parasitol Res ; 123(5): 206, 2024 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-38713306

RESUMO

The Australian skink Egernia stokesii had been recognised as a host of two species of Plasmodium, Plasmodium mackerrasae and P. circularis; nevertheless, molecular data are available for only a single haemosporidian species of this host. Its sequences are labelled as "Plasmodium sp." or "Plasmodium mackerrasae", but morphological characteristics of this isolate are unavailable. Phylogenetic analyses of these sequences placed them into the clade of the genus Haemocystidium. In this study, blood samples of six E. stokesii were analysed by both, molecular and microscopic methods to clarify the haemosporidia of this lizard. Application of these approaches offered discordant results. Whereas sequence analysis clustered our isolates with lizard species of Haemocystidium, morphology of blood stages is more akin to Plasmodium than Haemocystidium. However, limited sampling, indistinguishable nuclei/merozoites and risk of possible hidden presence of mixed infection prevent reliable species identification of detected parasites or their description as new species of Haemocystidium.


Assuntos
Haemosporida , Lagartos , Filogenia , Animais , Lagartos/parasitologia , Austrália , Haemosporida/genética , Haemosporida/classificação , Haemosporida/isolamento & purificação , DNA de Protozoário/genética , Análise de Sequência de DNA , Dados de Sequência Molecular , Análise por Conglomerados , DNA Ribossômico/genética , Microscopia , Sangue/parasitologia , RNA Ribossômico 18S/genética , Infecções Protozoárias em Animais/parasitologia
6.
FEMS Microbiol Rev ; 48(3)2024 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-38734892

RESUMO

Bloodstream infection is a major public health concern associated with high mortality and high healthcare costs worldwide. Bacteremia can trigger fatal sepsis whose prevention, diagnosis, and management have been recognized as a global health priority by the World Health Organization. Additionally, infection control is increasingly threatened by antimicrobial resistance, which is the focus of global action plans in the framework of a One Health response. In-depth knowledge of the infection process is needed to develop efficient preventive and therapeutic measures. The pathogenesis of bloodstream infection is a dynamic process resulting from the invasion of the vascular system by bacteria, which finely regulate their metabolic pathways and virulence factors to overcome the blood immune defenses and proliferate. In this review, we highlight our current understanding of determinants of bacterial survival and proliferation in the bloodstream and discuss their interactions with the molecular and cellular components of blood.


Assuntos
Bactérias , Humanos , Bacteriemia/microbiologia , Fatores de Virulência , Sangue/microbiologia , Viabilidade Microbiana
7.
Crit Care Explor ; 6(5): e1089, 2024 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-38728059

RESUMO

IMPORTANCE: Patients admitted with cerebral hemorrhage or cerebral edema often undergo external ventricular drain (EVD) placement to monitor and manage intracranial pressure (ICP). A strain gauge transducer accompanies the EVD to convert a pressure signal to an electrical waveform and assign a numeric value to the ICP. OBJECTIVES: This study explored ICP accuracy in the presence of blood and other viscous fluid contaminates in the transducer. DESIGN: Preclinical comparative design study. SETTING: Laboratory setting using two Natus EVDs, two strain gauge transducers, and a sealed pressure chamber. PARTICIPANTS: No human subjects or animal models were used. INTERVENTIONS: A control transducer primed with saline was compared with an investigational transducer primed with blood or with saline/glycerol mixtures in mass:mass ratios of 25%, 50%, 75%, and 100% glycerol. Volume in a sealed chamber was manipulated to reflect changes in ICP to explore the impact of contaminates on pressure measurement. MEASUREMENTS AND MAIN RESULTS: From 90 paired observations, ICP readings were statistically significantly different between the control (saline) and experimental (glycerol or blood) transducers. The time to a stable pressure reading was significantly different for saline vs. 25% glycerol (< 0.0005), 50% glycerol (< 0.005), 75% glycerol (< 0.0001), 100% glycerol (< 0.0005), and blood (< 0.0005). A difference in resting stable pressure was observed for saline vs. blood primed transducers (0.041). CONCLUSIONS AND RELEVANCE: There are statistically significant and clinically relevant differences in time to a stable pressure reading when contaminates are introduced into a closed drainage system. Changing a transducer based on the presence of blood contaminate should be considered to improve accuracy but must be weighed against the risk of introducing infection.


Assuntos
Pressão Intracraniana , Transdutores de Pressão , Pressão Intracraniana/fisiologia , Humanos , Sangue/metabolismo , Glicerol , Monitorização Fisiológica/instrumentação , Monitorização Fisiológica/métodos , Drenagem/instrumentação , Hemorragia Cerebral/fisiopatologia , Hemorragia Cerebral/diagnóstico
8.
J Forensic Sci ; 69(3): 1061-1068, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38415957

RESUMO

An investigation into whether the addition of a commonly used anti-coagulant agent like ethylenediaminetetraacetic acid (EDTA) has an impact on the adhesion potential of blood to non-porous substrates was conducted. Two non-porous substrates (aluminum and polypropylene) exhibiting six different surface roughness categories (R1-R6) were used as test substrates upon which either whole blood or blood treated with EDTA was deposited. Samples were exposed to different drying periods (24 hours, 48 hours, and 1 week) before undergoing a tapping agitation experiment in order to evaluate the adhesion to the surface. Clear differences in adhesion potential were observed between whole blood and blood treated with EDTA. Blood treated with EDTA displayed a stronger adhesion strength to aluminum after a drying time of 24 h pre-agitation, while whole blood presented with a stronger adhesion strength at the drying time of 48 h and 1 week. Both EDTA-treated and EDTA-untreated blood was shown to dislodge less easily on polypropylene with the only difference observed on smooth surfaces (0.51-1.50 µm surface roughness). Thus, when conducting transfer studies using smooth hydrophobic substrates like polypropylene or considering the likelihood of transfer given specific case scenarios, differences in adhesion strength of blood due to hydrophobic substrate characteristics and a decreased surface area need to be considered. Overall, whole blood displayed a better adhesion strength to aluminum, emphasizing that indirect transfer probability experiments using EDTA blood on substrates like aluminum should take an increased dislodgment tendency into account in their transfer estimations.


Assuntos
Alumínio , Anticoagulantes , Ácido Edético , Polipropilenos , Propriedades de Superfície , Ácido Edético/farmacologia , Humanos , Anticoagulantes/farmacologia , Adesividade , Manchas de Sangue , Sangue , Interações Hidrofóbicas e Hidrofílicas
9.
Ann Hum Biol ; 51(1): 1-6, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38251837

RESUMO

BACKGROUND: At present, there are no available genetic data on the AGCU EX22 Kit from the Wuhu Han population. AIM: This study investigates the applicability of the AGCU EX22 kit, designed for the Chinese population for forensic analysis and population genetics of the Wuhu Han population. SUBJECTS AND METHODS: Bloodstains from 1565 unrelated healthy individuals in Wuhu city, Anhui Province, were collected for analysis. The AGCU EX22 kit was used for amplification, and capillary electrophoresis was used to separate the amplification products. Allele frequencies and forensic parameters were determined. The Wuhu Han population was compared to 10 reference populations through genetic distance, a phylogenetic neighbor-joining tree and principal component analysis. RESULTS: In total, 281 alleles and 1187 genotypes were observed. No significant deviations from Hardy-Weinberg equilibrium at any locus were found after Bonferroni's correction. The 21 autosomal short tandem repeat (STR) genetic markers exhibited high informativeness and polymorphism. The cumulative power of discrimination and power of exclusion were 0.999999999999999999999999913380 and 0.999999996752339, respectively. Population comparisons revealed a genetic affinity between Wuhu Han and southern Han populations, except for the Guangdong Han population, which aligned with the traditional geographical division in China. CONCLUSION: The AGCU EX22 Kit, containing 21 STR loci, is suitable for forensic application and population genetics studies in the Wuhu Han population.


Assuntos
População do Leste Asiático , Repetições de Microssatélites , Humanos , Alelos , China , População do Leste Asiático/genética , Genética Forense , Frequência do Gene , Genética Populacional , Voluntários Saudáveis , Filogenia , Sangue
10.
Sci Total Environ ; 914: 169874, 2024 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-38185174

RESUMO

Human blood has been commonly and routinely analyzed to determine internal human exposure to parabens. However, data on the occurrence of parabens and their common metabolite, p-hydroxybenzoic acid (4-HB), in different human blood matrixes is still limited. In this study, 139 pairs of serum and whole blood samples were collected from Chinese adults, and then analyzed them for 5 parabens and 4-HB. Methylparaben (MeP) and propylparaben (PrP) were consistently the predominant parabens in human serum (mean 2.3 and 2.1 ng/mL, respectively) and whole blood (1.9 and 1.3 ng/mL, respectively). Mean concentrations of 4-HB in human serum and whole blood were 7.7 and 12 ng/mL, respectively. Concentrations of parabens, except benzylparaben (BzP), and 4-HB in human serum were significantly (p < 0.01) correlated with that in whole blood. Distribution pattern of parabens and 4-HB in human blood was evaluated, for the first time, based on their partitioning between human serum and whole blood (Kp). Mean Kp values of parabens, except BzP, increased with the alkyl chain length from 0.83 to 1.6. BzP (mean 1.4) had a comparable mean Kp value to PrP (mean 1.4). Among target analytes, 4-HB had the lowest mean Kp value (0.75). These data are important to select appropriate blood matrixes for conducting human exposure assessment and epidemiological studies on parabens.


Assuntos
Sangue , Parabenos , Adulto , Humanos , Parabenos/farmacocinética
11.
J Thromb Haemost ; 22(2): 311-314, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37940049
13.
Eur J Immunol ; 54(2): e2350519, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38103010

RESUMO

The human immune system is best accessible via tissues and organs not requiring major surgical intervention, such as blood. In many circumstances, circulating immune cells correlate with an individual's health state and give insight into physiological and pathophysiological processes. Stimulating whole blood ex vivo is a powerful tool to investigate immune responses. In the context of clinical research, the applications of whole blood stimulation include host immunity, disease characterization, diagnosis, treatment, and drug development. Here, we summarize different setups and readouts of whole blood assays and discuss applications for preclinical research and clinical practice. Finally, we propose combining whole blood stimulation with high-throughput technologies, such as single-cell RNA-sequencing, to comprehensively analyze the human immune system for the identification of biomarkers, therapeutic interventions as well as companion diagnostics.


Assuntos
Sangue , Sistema Imunitário , Humanos
14.
Braz. j. oral sci ; 23: e240327, 2024. ilus
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1553444

RESUMO

Aim: Venous blood derivatives (VBDs) have been suggested as substitutes for Fetal Bovine Serum (FBS) to improve the clinical transition of cell-based therapies. The literature is not clear about which is the best VBDs substitute. The present study aimed to evaluate the influence of VBDs on cell viability and describe a new method to seed these cells in a 3D Platelet-Rich Fibrin (PRF). Methods: Blood was processed to obtain Platelet-Poor Plasma from PRF (P-PRF), Human Serum (HS), Platelet-Poor Plasma from PRP (P-PRP), activated-PRP (a-PRP), and Platelet lysate (PL). Cells were supplemented with each VBD at 10% and FBS at 10% was the control. Cell viability (fibroblast 3T3/NIH) test was evaluated with MTT assay in two ways: i) cell-seeded and expanded with VBD; ii) cell-seed with FBS and expanded with VBD. To seed the Fibrin construct, cells were suspended in PBS and dropped into the blood sample before performing Choukroun's protocol for PRF. Constructs were cultured for 7 days in VBD supplements and FBS. Histological and Immunohistochemical analysis with vimentin was performed. Cell viability was analyzed by one-way ANOVA. Results: VBD's production time was very heterogeneous. Cells expanded in HS and a-PRP has grown faster. VBD-supplemented culture media provided cell culture highly sensible to trypsin/EDTA 0.25%. Cells seeded and expanded with VBD presented viability comparable to FBS in HS, a-PRP, and P-PRP (p>0.05) and lower in P-PRF and PL groups (p<0.05). The viability of cell seed with FBS and expanded with VBD was similar between P-PRF, a-PRP, PL, and FBS (p>0.05) and lower in HS and P-PRP (p<0.005). PRF-seeded cells showed a positive expression of vimentin and were able to maintain all cells supplemented with VBD. Conclusion: VBD supplements were able to maintain fibroblast cells in 2D and 3D cultures. The new method of the fibrin-cell construct was efficient to insert the cells into the fibrin network


Assuntos
Sangue , Plaquetas , Soroalbumina Bovina , Fibrina , Células , Fibroblastos , Fibrina Rica em Plaquetas
18.
Appl Opt ; 62(36): 9462-9469, 2023 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-38108770

RESUMO

A design of a photonic crystal nanocavity based bio-sensor having a footprint of 12×8µm 2 is proposed to detect different blood components. A finite difference time domain (FDTD) numerical technique has been used to characterize the sensor by evaluating its frequency response. The shift in resonant wavelength of the proposed cavity is utilized to detect blood refractive index fluctuation due to the presence of various components. The obtained numerical findings show that the maximum sensitivity for a shift in resonant wavelength is reported as 760 nm/RIU for various blood components. Moreover, the fabrication of PhC is always prone to the fabrication induced disorders. Hence, the impact of fabrication imperfections on the sensor's performance also has been included in the analysis.


Assuntos
Técnicas Biossensoriais , Análise Química do Sangue , Fótons , Sangue
19.
Ann Parasitol ; 69(2): 61-65, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38007222

RESUMO

In the experiment, 160 medicinal leeches of the species Hirudo verbana Carena, 1820 were studied. Medicinal leeches were fed on the blood of animals and people (conditionally healthy and diseased). Four leeches were taken from each animal/person. The animals were studied for 3 weeks. Mortality was mostly observed in the first days after feeding on the blood of the host. We noted mortality, the appearance of constrictions on the leeches' body, the intensity of the host blood spitting from their body. The host's blood was taken from their stomach on the first day after feeding. Hematological and immunological indicators of blood were determined in the taken blood of the host. As a result of the study of the blood of the sick, significant changes were found, compared to conditionally healthy ones. It was manifested by an increase in erythrocytes and leukocytes. The leukocyte formula looked like in most pathological conditions of the inflammatory process. The obtained indicators of the experiment make it possible to quickly assess the presence of physiological disorders in the early stages of the disease.


Assuntos
Sanguessugas , Animais , Humanos , Sangue , Eritrócitos/patologia , Leucócitos/patologia
20.
San Salvador; MINSAL; sept. 04, 2023. 70 p. ilus, graf.
Não convencional em Espanhol | BISSAL, LILACS | ID: biblio-1510000

RESUMO

El presente manual de procesos y procedimientos documenta los servicios que se ofrecen en la atención al usuario interno y externo para la gestión de la sangre, inmunohematología y hemoterapia como parte del proceso de atención en salud integral e integrada a la persona en el curso de vida con enfoque de atención primaria en salud, describe el sistema de operación ofrecido en los establecimientos de salud, mediante el enfoque por procesos, fomentando así el desarrollo organizacional y el mejoramiento continuo para el cumplimiento de la misión institucional. Establece las bases para la ejecución de los procedimientos como parte de los procesos institucionales, unificando criterios de contenido que permite la sistematización de las actividades y la definición de la metodología para efectuarlas. Esta herramienta táctica y operativa, permite integrar las actividades y tareas de manera oportuna, para el logro de la prestación de servicios con calidad en los establecimientos de salud que lo necesiten, facilitando el cumplimiento de las normativas y lineamientos de programas especiales o por ciclo de vida vigentes en el Ministerio de Salud, así como la armonización con la sistematización y uso de herramientas tecnológicas que sea necesario implementar para volver más eficaz el trabajo del talento humano en salud


This manual of processes and procedures documents the services offered in the care of internal and external users for blood management, immunohematology and hemotherapy as part of the process of comprehensive and integrated health care for the person throughout the life course. With a focus on primary health care, it describes the operation system offered in health establishments, through the process approach, thus promoting organizational development and continuous improvement to fulfill the institutional mission. Establishes the bases for the execution of procedures as part of institutional processes, unifying content criteria that allows the systematization of activities and the definition of the methodology to carry them out. This tactical and operational tool allows the integration of activities and tasks in a timely manner, to achieve the provision of quality services in the health establishments that need it, facilitating compliance with the regulations and guidelines of special programs or by cycle of life in force in the Ministry of Health, as well as harmonization with the systematization and use of technological tools that need to be implemented to make the work of human talent in health more effective


Assuntos
Sangue , Antígenos de Grupos Sanguíneos , Serviço de Hemoterapia , Manuais como Assunto , El Salvador
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...