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1.
Eur J Radiol ; 143: 109945, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34492625

RESUMO

OBJECTIVE: To investigate the role of quantitative muscle biomarkers assessed with skeletal muscle index at the third lumbar vertebra (L3-SMI) and temporal muscle thickness (TMT) in predicting progression-free and overall survival in patients with primary central nervous system lymphoma (PCNSL) undergoing first-line high-dose methotrexate-based chemotherapy. METHODS: L3-SMI and TMT were calculated on abdominal CT and brain high-resolution 3D-T1-weighted MR images, respectively, using predefined validated methods. Standardized sex-specific cut-off values were used to divide patients in different risk categories. Kaplan-Meier plots were calculated, and survival analysis was performed using log-rank tests, univariate, and multivariable Cox-regression models, calculating hazard ratios (HR) and 95% confidence intervals (CI), also adjusting for potential confounders (age, sex, and performance status). RESULTS: Forty-three patients were included in this study. Median follow-up was 23 months (interquartile range 12-40); at median follow-up, rates of progression-free and overall survival for the cohort were 46% and 57%, respectively. Thirteen (30%) and 11 (26%) patients showed L3-SMI or TMT values below the predefined cut-offs. In Cox-regression multivariable analysis patients with low L3-SMI or TMT showed significantly worse progression-free (HR 4.40, 95% CI 1.66-11.61, p = 0.003; HR 4.40, 95% CI 1.68-11.49, p = 0.003, respectively) and overall survival (HR 3.16, 95% CI 1.09-9.11, p = 0.034; HR 4.93, 95% CI 1.78-13.65, p = 0.002, respectively) compared to patients with high L3-SMI or TMT. CONCLUSIONS: Quantitative muscle mass evaluation assessed by both L3-SMI and TMT is a promising tool to identify PCNSL patients at high risk of negative outcome. Confirmatory studies on larger independent series are warranted.


Assuntos
Linfoma não Hodgkin , Sarcopenia , Biomarcadores , Sistema Nervoso Central , Feminino , Humanos , Linfoma não Hodgkin/patologia , Masculino , Músculo Esquelético/patologia , Prognóstico , Estudos Retrospectivos , Sarcopenia/patologia , Músculo Temporal , Tomografia Computadorizada por Raios X
2.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ; 33(8): 994-998, 2021 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-34590570

RESUMO

OBJECTIVE: To observe the clinical effect of Senling Baizhu san (SLBZS) on patients with sarcopenia. METHODS: Eighty patients with spleen-stomach weakness sarcopenia admitted to the department of geriatrics of Hangzhou Third People's Hospital from January 2018 to March 2020 were enrolled. The patients were divided into control group and observation group by random number table method, 40 cases in each group. All patients were treated with conventional Western medicine, and the observation group was treated with SLBZS 100 mL, twice a day, on the basis of conventional Western medicine. The course of the treatments was 12 weeks. Grip strength and walking speed were recorded before and after treatment, and appendicular skeletal mass index (ASMI) was calculated. The serum levels of silence infor-mation regulator 1 (SIRT1), growth differentiation factor-8 (GDF-8) and insulin-like rowth factor-1 (IGF-1) were detected by enzyme linked immunosorbent assay (ELISA). The mRNA expression of AMP-activated protein kinase-α (AMPK-α) in serum was detected by real-time quantitative polymerase chain reaction (RT-qPCR). RESULTS: Compared with before treatment, grip strength, ASMI, IGF-1, SIRT1 and AMPK-α mRNA in both groups were significantly increased after treatment, while GDF-8 was significantly decreased. The changes of above indexes in the observation group were more significant than those in the control group after treatment [grip strength (kg): 20.00 (15.50, 21.00) vs. 18.20 (14.93, 19.50), ASMI (kg/m2): 5.80 (5.25, 6.00) vs. 5.30 (5.20, 5.50), IGF-1 (µg/L): 246.00 (229.00, 259.50) vs. 207.00 (187.00, 233.00), SIRT1 (ng/L): 649.2±38.3 vs. 624.6±38.6, AMPK-α mRNA (2-ΔΔCt): 0.30±0.03 vs. 0.27±0.03, GDF-8 (µg/L): 13.50 (12.00, 17.80) vs. 15.60 (14.08, 19.98), all P < 0.05]. There was no significant difference in walking speed between the two groups before and after treatment [0.56 (0.53, 0.62) m/s and 0.58 (0.55, 0.62) m/s in the control group before and after treatment, 0.58 (0.54, 0.64) m/s and 0.60 (0.56, 0.65) m/s in the observation group before and after treatment, both P > 0.05]. Spearman correlation analysis showed that IGF-1 was positively correlated with SIRT1 (r = 0.341, P = 0.002), IGF-1 was positively correlated with walking speed (r = 0.250, P = 0.026), and ASMI was positively correlated with grip strength (r = 0.367, P = 0.001). CONCLUSIONS: On the basis of conventional Western medicine, SLBZS has a remarkable effect on patients with sarcopenia of spleen-stomach weakness, which can provide a new idea of combining traditional Chinese and Western medicine for the treatment of sarcopenia.


Assuntos
Fragilidade , Sarcopenia , Humanos , Sarcopenia/tratamento farmacológico
3.
BMC Musculoskelet Disord ; 22(1): 807, 2021 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-34544407

RESUMO

BACKGROUND: Previous research has described a neuroprotective effect of IGF-I, supporting neuronal survival, axon growth and proliferation of muscle cells. Therefore, the association between IGF-I concentration, muscle histology and electrophysiological markers in a cohort of patients with sarcopenia dares investigation. METHODS: Measurement of serum concentrations of IGF-I and binding partners, electromyographic measurements with the MUNIX (Motor Unit Number Index) method and muscle biopsies were performed in 31 patients with acute hip fracture older age 60 years. Molecular markers for denervation (neural cell adhesion molecule NCAM) and proliferation markers (Ki67) were assessed by immunofluorescence staining of muscle biopsy tissue. Skeletal muscle mass by bioelectrical impedance analysis and hand-grip strength were measured to assess sarcopenia status according to EWGSOP2 criteria. RESULTS: Thirty-one patients (20 women) with a mean age of 80.6 ± 7.4 years were included. Concentrations of IGF-I and its binding partners were significantly associated with sarcopenia (ß = - 0.360; p = 0.047) and MUNIX (ß = 0.512; p = 0.005). Further, expression of NCAM (ß = 0.380; p = 0.039) and Ki67 (ß = 0.424; p = 0.022) showed significant associations to IGF-I concentrations. CONCLUSIONS: The findings suggest a pathogenetic role of IGF-I in sarcopenia based on muscle denervation.


Assuntos
Sarcopenia , Idoso , Idoso de 80 Anos ou mais , Feminino , Força da Mão , Humanos , Fator de Crescimento Insulin-Like I , Músculo Esquelético/patologia , Regeneração , Sarcopenia/diagnóstico
4.
Medicine (Baltimore) ; 100(36): e27212, 2021 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-34516526

RESUMO

ABSTRACT: We aimed to prospectively identify the risk factors of sarcopenia in patients with cirrhosis.Patients (n = 193) included in a discovery cohort (January 2011 and December 2014) were categorized into alcoholic (A1; n = 55) and non-alcoholic cirrhosis (NA; n = 138) groups, and those (n = 235) in a validation cohort (January 2015 to December 2019) were categorized into alcoholic (n = 92), non-alcoholic steatohepatitis-related (n = 27), and hepatitis C virus-related cirrhosis groups (n = 116). Skeletal muscle mass index (SMI) was determined using computed tomography (SMI-CT) and bioelectrical impedance analysis (SMI-BIA). Endotoxin activity (EA) was measured with an EA assay.SMI-CT correlated with grip strength in all the groups but significantly correlated with SMI-BIA of the men in group A1 (R = 0.64, P < .0001) and both sexes in group NA (male: R = 0.44, P = .0001; female: R = 0.35, P = .003). SMI-CT inversely correlated with the EA levels of the men in group A1 (R = -0.67, P < .0001) and myostatin levels in group NA (R = -0.53, P < .0001). Lower extremity SMI had a strong negative correlation with the EA levels of the men in group A1 (R = -0.58, P < .001), whereas upper extremity SMI showed an inverse trend with EA levels (R = -0.28, P = .08). SMI-CT also inversely correlated with the EA levels in groups A2 (R = -0.52, P = .003) and N (R = -0.67, P < .0001) and myostatin levels in group C (R = -0.65, P < .0001). Moreover, SMI-CT correlated with nutritional factors, including cholinesterase (R = 0.50, P = .005), zinc (R = 0.45, P = .01), branched amino acid-to-tyrosine ratio (R = 0.39, P = .02), and triglyceride (R = 0.33, P = .03) in group N.Sarcopenia risk factors differ among cirrhosis etiologies. Alcohol-induced, intestine-mediated peripheral endotoxemia could participate in sarcopenia development in patients with alcoholic cirrhosis.


Assuntos
Endotoxinas/metabolismo , Cirrose Hepática Alcoólica , Músculo Esquelético/metabolismo , Sarcopenia/epidemiologia , Idoso , Estudos de Coortes , Feminino , Humanos , Japão/epidemiologia , Masculino , Prevalência , Estudos Retrospectivos , Fatores de Risco , Sarcopenia/diagnóstico por imagem , Sarcopenia/etiologia , Tomografia Computadorizada por Raios X
5.
J Nutr Health Aging ; 25(8): 1028-1029, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34545924

RESUMO

OBJECTIVE: This study aimed to screen for a one year Brazilian elderly women who were physically active before of COVID-19 pandemic-induced lockdown and to assess the consequences of physical inactivity on body weight and muscle function loss. MEASUREMENTS: A cohort study of one-year was conducted with twenty-nine physically active elderly (65.5±5.6y) women. Pre-assessment was took in December 2019 and post (a year later) was performed in January 2021, during the lockdown induced by COVID-19 pandemic. Body mass (kg) was obtained using the digital scale. Handgrip strength (HGS) of the non-dominant hand was determined using an electronic dynamometer. Muscle function loss was assessed using the SARC-F questionnaire. RESULTS: After one year, body weight (p=0.002) and BMI (p=0.001) increased significantly, with an average percentage of change in body mass of +3.0±5.2%. Consequently, there was a change in classification of BMI pre- and post-one year (malnutrition: 17.2% to 17.2%, normal weight: 41.4% to 37.9%, and overweight: 41.4% to 44.9%). Additionally, was found increased muscle function loss (SARC-F≥4) of 13.8% to 27.6% of elderly women. CONCLUSION: In Brazilian physically active elderly women, we found that the physical inactivity imposed by during the lockdown increased the body mass and muscle function loss.


Assuntos
Peso Corporal , COVID-19 , Músculos/fisiologia , Pandemias , Sarcopenia , Ganho de Peso , Idoso , COVID-19/epidemiologia , Estudos de Coortes , Controle de Doenças Transmissíveis , Feminino , Força da Mão , Humanos , Pessoa de Meia-Idade , Quarentena , SARS-CoV-2
6.
Trials ; 22(1): 621, 2021 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-34526100

RESUMO

BACKGROUND: Colorectal cancer is associated with secondary sarcopenia (muscle loss) and myosteatosis (fatty infiltration of muscle) and patients who exhibit these host characteristics have poorer outcomes following surgery. Furthermore, patients, who undergo curative advanced rectal cancer surgery such as pelvic exenteration, are at risk of skeletal muscle loss due to immobility, malnutrition and a post-surgical catabolic state. Neuromuscular electrical stimulation (NMES) may be a feasible adjunctive treatment to help ameliorate these adverse side-effects. Hence, the purpose of this study is to investigate NMES as an adjunctive pre- and post-operative treatment for rectal cancer patients in the radical pelvic surgery setting and to provide early indicative evidence of efficacy in relation to key health outcomes. METHOD: In a phase II, double-blind, randomised controlled study, 58 patients will be recruited and randomised (1:1) to either a treatment (NMES plus standard care) or placebo (sham-NMES plus standard care) group. The intervention will begin 2 weeks pre-operatively and continue for 8 weeks after exenterative surgery. The primary outcome will be change in mean skeletal muscle attenuation, a surrogate marker of myosteatosis. Sarcopenia, quality of life, inflammatory status and cancer specific outcomes will also be assessed. DISCUSSION: This phase II randomised controlled trial will provide important preliminary evidence of the potential for this adjunctive treatment. It will provide guidance on subsequent development of phase 3 studies on the clinical benefit of NMES for rectal cancer patients in the radical pelvic surgery setting. TRIAL REGISTRATION: Protocol version 6.0; 05/06/20. ClinicalTrials.gov NCT04065984 . Registered on 22 August 2019; recruiting.


Assuntos
Terapia por Estimulação Elétrica , Neoplasias Retais , Sarcopenia , Ciclismo , Estimulação Elétrica , Terapia por Estimulação Elétrica/efeitos adversos , Humanos , Qualidade de Vida , Neoplasias Retais/complicações , Neoplasias Retais/cirurgia , Sarcopenia/diagnóstico , Sarcopenia/etiologia , Sarcopenia/terapia
9.
Ann Palliat Med ; 10(8): 9136-9148, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34488399

RESUMO

BACKGROUND: As the aging population continues to increase worldwide, the prevalence of cardiovascular diseases and muscular dystrophy/sarcopenia in the elderly has escalated significantly. Cardiovascular diseases elevate the risk of muscular atrophy/sarcopenia, which results in increased disability and mortality of patients. This study analyzed the current available literature related to the relationship between cardiovascular diseases and muscular atrophy/sarcopenia in the aging population. METHODS: The Science Citation Index Expanded (SCI-E) database was searched for related literature published between 1900 and March 14, 2021. The subject search was performed using the search terms "muscular atrophy" and "sarcopenia". The search formula was "muscular atrophy OR sarcopenia". The search scope was limited to "cardiovascular diseases OR cardiac & cardiovascular systems". All search results and cited references were exported in plain text format and Citespace software was used to analyze the publications in terms of year of publication, country and institution, journal of publication, authors, and keywords. RESULTS: A total of 1,004 related research documents were obtained, with a citation frequency of 26,705 times. The top five countries for the highest number of published documents were the United States, Japan, Germany, South Korea, and Italy. The top five countries involved in research cooperation were the United States, Japan, the United Kingdom, Spain, and Germany, however, overall, there was little cooperation between countries, institutions, and authors. A number of researchers from Germany published the most documents. The author with the most cited publication was Cruz-Jentoft et al. from Spain, which deserves special attention. Professional journals of in the field of geriatrics play a significant role in this research topic. Analysis of the keywords showed that current researchers are mainly concerned with the associated risk of death. CONCLUSIONS: The relationship between muscular atrophy/sarcopenia and cardiovascular diseases is currently a hot topic of research in geriatrics and cardiovascular disease, and further studies examining the mechanisms involved and potential prevention strategies are warranted.


Assuntos
Doenças Cardiovasculares , Sarcopenia , Idoso , Bibliometria , Alemanha , Humanos , Reino Unido , Estados Unidos
10.
In Vivo ; 35(5): 2909-2915, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34410986

RESUMO

AIM: Sarcopenia affects the treatment of various cancer types but its impact on chemotherapy efficacy and prognosis in biliary tract cancer remains unclear. Thus, we evaluated whether sarcopenia independently affects the outcome of chemotherapy for biliary tract cancer. PATIENTS AND METHODS: Data of 50 patients who underwent chemotherapy for biliary tract cancer at two affiliated centres were retrospectively analysed. The association of clinical factors, including sarcopenia, with overall survival and time to treatment failure was analysed. RESULTS: Sarcopenia was an independent factor negatively influencing overall survival and time to treatment failure in univariate and multivariate analyses (median overall survival, sarcopenic vs. non-sarcopenic patients: 10.6 vs. 16.6 months; hazard ratio=2.19, p=0.018; time to treatment failure: 5.3 vs. 13.1 months, hazard ratio=2.50, p=0.019). CONCLUSION: Sarcopenia may affect the efficacy of chemotherapy and prognosis in biliary tract cancer. Thus, improving sarcopenia may improve the prognosis of patients with biliary tract cancer undergoing chemotherapy.


Assuntos
Neoplasias do Sistema Biliar , Sarcopenia , Neoplasias do Sistema Biliar/complicações , Neoplasias do Sistema Biliar/tratamento farmacológico , Humanos , Prognóstico , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Sarcopenia/complicações , Sarcopenia/diagnóstico
11.
Nutrients ; 13(8)2021 Aug 08.
Artigo em Inglês | MEDLINE | ID: mdl-34444886

RESUMO

Skeletal muscle wasting in the intensive care unit (ICU) has been associated with mortality, but it is unclear whether sarcopenia, defined by skeletal muscle mass and function, is useful for detailed risk stratification after ICU discharge. In this cohort study, 72 critically ill patients with an ICU stay of ≥48 h were identified. Skeletal muscle mass was assessed from the muscle thickness (MT) of the patients' quadriceps using ultrasound images before ICU discharge. Skeletal muscle function was assessed from the patients' muscle strength (MS) before ICU discharge according to the Medical Research Council sum score. A diagnosis of sarcopenia in the ICU was made in patients with low MT and low MS. The study endpoint was 1-year mortality. Sarcopenia in the ICU was diagnosed in 26/72 patients (36%). After adjusting for covariates in the Cox regression, sarcopenia in the ICU was significantly associated with 1-year mortality (hazard ratio 3.82; 95% confidence interval, 1.40-10.42). Sarcopenia in the ICU, defined by low skeletal muscle mass and function, was associated with 1-year mortality in survivors of critical illness. Skeletal muscle mass and function assessed at the bedside could be used to identify higher-risk patients in the ICU.


Assuntos
Estado Terminal/mortalidade , Avaliação Nutricional , Alta do Paciente/estatística & dados numéricos , Sarcopenia/mortalidade , Sobreviventes/estatística & dados numéricos , Idoso , Estudos de Coortes , Feminino , Humanos , Unidades de Terapia Intensiva , Masculino , Pessoa de Meia-Idade , Força Muscular , Músculo Esquelético/fisiopatologia , Modelos de Riscos Proporcionais , Músculo Quadríceps/diagnóstico por imagem , Músculo Quadríceps/fisiopatologia , Medição de Risco , Sarcopenia/diagnóstico , Ultrassonografia
12.
Int J Mol Sci ; 22(16)2021 Aug 23.
Artigo em Inglês | MEDLINE | ID: mdl-34445808

RESUMO

Magnesium (Mg) is a pivotal and very complex component of healthy aging in the cardiovascular-muscle-bone triad. Low Mg levels and low Mg intake are common in the general aging population and are associated with poorer outcomes than higher levels, including vascular calcification, endothelial dysfunction, osteoporosis, or muscle dysfunction/sarcopenia. While Mg supplementation appears to reverse these processes and benefit the triad, more randomized clinical trials are needed. These will allow improvement of preventive and curative strategies and propose guidelines regarding the pharmaceutical forms and the dosages and durations of treatment in order to optimize and adapt Mg prescription for healthy aging and for older vulnerable persons with comorbidities.


Assuntos
Doenças Cardiovasculares/metabolismo , Magnésio/metabolismo , Osteoporose/metabolismo , Sarcopenia/metabolismo , Envelhecimento/metabolismo , Animais , Osso e Ossos/metabolismo , Envelhecimento Saudável/metabolismo , Humanos , Força Muscular/fisiologia , Músculo Esquelético/metabolismo
14.
Clin Nutr ; 40(8): 4822-4823, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34352604

Assuntos
Sarcopenia , Humanos
15.
Nutrients ; 13(8)2021 Aug 23.
Artigo em Inglês | MEDLINE | ID: mdl-34445056

RESUMO

Musculoskeletal deficits are among the most commonly reported extra-intestinal manifestations and complications of inflammatory bowel disease (IBD), especially in those with Crohn's disease. The adverse effects of IBD on bone and muscle are multifactorial, including the direct effects of underlying inflammatory disease processes, nutritional deficits, and therapeutic effects. These factors also indirectly impact bone and muscle by interfering with regulatory pathways. Resultantly, individuals with IBD are at increased risk of osteoporosis and sarcopenia and associated musculoskeletal morbidity. In paediatric IBD, these factors may contribute to suboptimal bone and muscle accrual. This review evaluates the main pathogenic factors associated with musculoskeletal deficits in children and adults with IBD and summarises the current literature and understanding of the musculoskeletal phenotype in these patients.


Assuntos
Colite Ulcerativa/complicações , Doença de Crohn/complicações , Doenças Musculoesqueléticas/etiologia , Sarcopenia/etiologia , Fatores Etários , Composição Corporal , Remodelação Óssea , Colite Ulcerativa/sangue , Colite Ulcerativa/fisiopatologia , Doença de Crohn/sangue , Doença de Crohn/tratamento farmacológico , Doença de Crohn/fisiopatologia , Citocinas/sangue , Glucocorticoides/efeitos adversos , Humanos , Mediadores da Inflamação/sangue , Doenças Musculoesqueléticas/sangue , Doenças Musculoesqueléticas/fisiopatologia , Estado Nutricional , Osteoporose/sangue , Osteoporose/etiologia , Osteoporose/fisiopatologia , Medição de Risco , Fatores de Risco , Sarcopenia/sangue , Sarcopenia/fisiopatologia
16.
Int J Rehabil Res ; 44(3): 269-275, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34356039

RESUMO

Our aim was to investigate the prevalence of sarcopenia in stroke patients, the relationship between sarcopenia detected with different low muscle mass (LMM) adjustment methods, and between stroke-related parameters. Eighty-one patients with chronic stroke who underwent inpatient rehabilitation were included. Spasticity was evaluated by modified Ashworth scale, Brunnstrom staging approach was used for motor function evaluation, physical independence was evaluated using Barthel Index, quality-of-life was evaluated by EQ-5D-3L, and the Cumulative Illness Rating Scale was used to measure multimorbidity. Muscle strength was evaluated by handgrip strength, muscle quantity through a bioelectric impedance analysis, and physical performance by gait speed and short physical performance battery. LMM was calculated through two different methods: Skeletal muscle mass (SMM)/height2, and SMM/BMI. For the definition of sarcopenia, we followed the EWGSOP2 recommendation. Associated sarcopenia factors were predicted by multivariate binary logistic regression analysis. The prevalence of probable sarcopenia was 32.1%. The prevalence of confirmed/sarcopenia when LMM was adjusted for BMI was higher than when adjusted for height2 (16 and 1.2%, respectively). Age was significantly higher in those with probable sarcopenia (P = 0.006). Stroke duration was shorter in those with probable or confirmed sarcopenia (P = 0.004, P < 0.001, respectively). EQ-5D-3L scores were significantly lower in those with confirmed sarcopenia (P = 0.050). The strongest associated factor with confirmed sarcopenia was stroke duration (OR: 0.77; 95% CI, 0.618-0.965). This study suggests that prevalence of sarcopenia after a stroke is significantly high. LMM adjusted for BMI comes in front as the adjustment method for LMM after a stroke.


Assuntos
Sarcopenia , Reabilitação do Acidente Vascular Cerebral , Acidente Vascular Cerebral , Estudos Transversais , Força da Mão , Humanos , Força Muscular , Músculo Esquelético , Prevalência , Sarcopenia/epidemiologia , Sarcopenia/etiologia , Acidente Vascular Cerebral/complicações
17.
Int J Mol Sci ; 22(16)2021 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-34445751

RESUMO

Sarcopenia, the age-related decline in muscle mass and function, derives from multiple etiological mechanisms. Accumulative research suggests that reactive oxygen species (ROS) generation plays a critical role in the development of this pathophysiological disorder. In this communication, we review the various signaling pathways that control muscle metabolic and functional integrity such as protein turnover, cell death and regeneration, inflammation, organismic damage, and metabolic functions. Although no single pathway can be identified as the most crucial factor that causes sarcopenia, age-associated dysregulation of redox signaling appears to underlie many deteriorations at physiological, subcellular, and molecular levels. Furthermore, discord of mitochondrial homeostasis with aging affects most observed problems and requires our attention. The search for the primary suspect of the fundamental mechanism for sarcopenia will likely take more intense research for the secret of this health hazard to the elderly to be unlocked.


Assuntos
Proteínas Musculares/metabolismo , Estresse Oxidativo , Sarcopenia/etiologia , Sarcopenia/metabolismo , Transdução de Sinais , Proteínas Quinases Ativadas por AMP/metabolismo , Animais , Apoptose , Homeostase , Humanos , Inflamação/metabolismo , Mitocôndrias/metabolismo , NAD/metabolismo , Junção Neuromuscular/metabolismo , Oxirredução , Peroxirredoxinas/metabolismo , Regeneração
18.
Nutr Metab Cardiovasc Dis ; 31(10): 2935-2944, 2021 09 22.
Artigo em Inglês | MEDLINE | ID: mdl-34420817

RESUMO

BACKGROUND AND AIMS: In this study, we examined the relationships of appendicular skeletal muscle mass (ASM) and grip strength (GS) with carotid intima-media thickness (CIMT) and plaque score (PS) in patients with type 2 diabetes. METHODS AND RESULTS: A total of 1185 patients were recruited. High CIMT and high PS were defined as ≥ 75 percentile of maximal CIMT of each sex and PS ≥ 3. Patients in the lowest ASM/body mass index (BMI) or GS/BMI tertile were older and had lower HDL cholesterol, and eGFR, but higher BMI, waist circumference (WC), HOMA-IR, and C-reactive protein than those in the highest tertile. Meanwhile, individuals in the lowest ASM or GS tertile group had lower BMI and WC than those in the highest one. CIMT and PS and the prevalence of high CIMT, carotid plaques, and high PS gradually increased with decreasing tertiles of ASM, ASM/BMI, GS, and GS/BMI (p < 0.001). After adjusting for age and sex, odds ratios (ORs) and 95% confidence intervals (CIs) for high CIMT and high PS were 0.98 (0.68-1.42), 1.64 (1.14-2.36), 2.000 (1.33-3.01), and 1.77 (1.22-2.58) and 1.63 (1.16-2.30), 1.78 (1.28-2.54), 1.91 (1.33-2.75), and 1.61 (1.13-2.28) in the lowest tertile of ASM, ASM/BMI, GS, and GS/BMI, respectively. After further adjusting for potential confounders, ORs and 95% CI for high CIMT and high PS remained significant in the lowest tertile group. CONCLUSIONS: Low ASM and low GS may be independent risk factors for high CIMT and high PS in patients with type 2 diabetes.


Assuntos
Absorciometria de Fóton , Composição Corporal , Doenças das Artérias Carótidas/diagnóstico por imagem , Espessura Intima-Media Carotídea , Diabetes Mellitus Tipo 2/diagnóstico , Força da Mão , Músculo Esquelético/diagnóstico por imagem , Placa Aterosclerótica , Sarcopenia/diagnóstico por imagem , Idoso , Índice de Massa Corporal , Doenças das Artérias Carótidas/epidemiologia , Estudos Transversais , Diabetes Mellitus Tipo 2/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/fisiopatologia , Valor Preditivo dos Testes , Prevalência , República da Coreia/epidemiologia , Medição de Risco , Fatores de Risco , Sarcopenia/epidemiologia , Sarcopenia/fisiopatologia
19.
J Comput Assist Tomogr ; 45(5): 684-690, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34407059

RESUMO

OBJECTIVE: We evaluated the prognostic impacts of body composition components measured by computed tomography (CT) in patients with liver cirrhosis. METHODS: A total of 160 cirrhotic patients who underwent CT and hepatic venous pressure gradient measurements were retrospectively enrolled. Cross-sectional areas of skeletal muscle, visceral and subcutaneous fat, and mean CT attenuation of trabecular bone of the fourth lumbar vertebral level (L4HU) were measured. RESULTS: Multivariate analysis showed model for end-stage liver disease score [hazard ratio (HR), 1.086; 95% confidence interval (CI), 1.020-1.156; P = 0.010], hepatic venous pressure gradient (HR, 1.076; 95% CI, 1.021-1.135; P = 0.006), sarcopenia (HR, 1.890; 95% CI, 1.032-3.462; P = 0.039), and L4HU (HR, 1.960 for L4HU <145 Hounsfield units; 95% CI, 1.094-3.512; P = 0.024) were independently associated with long-term mortality. In patients with decompensated cirrhosis, subcutaneous adipose tissue index was the only independent predictor (HR, 0.984; 95% CI, 0.969-0.999; P = 0.039). CONCLUSION: Body composition abnormalities determined by CT are associated with long-term prognosis in cirrhotic patients.


Assuntos
Composição Corporal , Densidade Óssea , Doença Hepática Terminal/diagnóstico por imagem , Cirrose Hepática/mortalidade , Sarcopenia/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Tecido Adiposo/diagnóstico por imagem , Doença Hepática Terminal/mortalidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/diagnóstico por imagem , Valor Preditivo dos Testes , Prognóstico , República da Coreia/epidemiologia , Estudos Retrospectivos , Sarcopenia/mortalidade , Índice de Gravidade de Doença , Análise de Sobrevida
20.
Geriatr Gerontol Int ; 21(10): 950-958, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34405954

RESUMO

AIMS: Coffee consumption has been suggested, in animal studies, to inhibit the progression of sarcopenia, possibly through its anti-inflammatory effects; however, few studies have been carried out in humans. We aimed to examine whether coffee consumption was related to indicators of sarcopenia in a Japanese population, and whether the association was mediated by reduced inflammation. METHODS: This study was a cross-sectional design. Participants were community residents (n = 6369) aged 45-74 years. We measured skeletal muscle mass index (SMI; kg/m2 ) by a bioelectrical impedance method, and grip strength with a Smedley-type dynamometer. Habitual coffee consumption was assessed by a self-administered questionnaire. Serum high-sensitivity C-reactive protein was measured as an inflammatory marker. The association between habitual coffee consumption and SMI or grip strength was analyzed with a linear regression model adjusted for covariates. RESULTS: A significant positive association was found between coffee consumption and SMI (men: ß = 0.023; Ptrend  = 0.004, women: ß = 0.011; Ptrend  = 0.012). Further adjustment for high-sensitivity C-reactive protein did not materially alter the results (men: ß = 0.023; Ptrend  = 0.005, women: ß = 0.009; Ptrend  = 0.024). The relationship between coffee consumption and grip strength did not reach statistical significance; however, a positive trend was observed (men: ß = 0.208; Ptrend  = 0.085, women: ß = 0.092; Ptrend  = 0.167). CONCLUSIONS: We found that coffee consumption was positively associated with SMI independently of inflammation in middle-aged and older Japanese people. Reduced inflammation by coffee does not seem to be an important mediator, and further investigations are required to explore the mechanisms of this association. Geriatr Gerontol Int 2021; 21: 950-958.


Assuntos
Café , Sarcopenia , Idoso , Estudos Transversais , Feminino , Humanos , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Músculo Esquelético , Sarcopenia/epidemiologia
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