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1.
Sci Total Environ ; 751: 141627, 2021 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-33181982

RESUMO

Direct contact with toxicants in crude oil during embryogenesis causes cardiovascular defects, but the effects of exposure to airborne volatile organic compounds released from spilled oil are not well understood. The effects of crude oil-derived airborne toxicants on peripheral blood flow were examined in Gulf killifish (Fundulus grandis) since this model completes embryogenesis in the air. Particle image velocimetry was used to measure in vivo blood flow in intersegmental arteries of control and oil-exposed embryos. Significant effects in oil-exposed embryos included increased pulse rate, reduced mean blood flow speed and volumetric flow rate, and decreased pulsatility, demonstrating that normal-appearing oil-exposed embryos retain underlying cardiovascular defects. Further, hematocrit moderately increased in oil-exposed embryos. This study highlights the potential for fine-scale physiological measurement techniques to better understand the sub-lethal effects of oil exposure and demonstrates the efficacy of Gulf killifish as a unique teleost model for aerial toxicant exposure studies.


Assuntos
Sistema Cardiovascular , Circulação Coronária , Fundulidae , Poluição por Petróleo , Petróleo , Poluentes Químicos da Água , Animais , Circulação Coronária/efeitos dos fármacos , Poluição por Petróleo/efeitos adversos , Poluentes Químicos da Água/toxicidade
2.
Radiographics ; 40(7): 1866-1892, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33136488

RESUMO

Infection with severe acute respiratory syndrome coronavirus 2 results in coronavirus disease 2019 (COVID-19), which was declared an official pandemic by the World Health Organization on March 11, 2020. COVID-19 has been reported in most countries, and as of August 15, 2020, there have been over 21 million cases of COVID-19 reported worldwide, with over 800 000 COVID-19-associated deaths. Although COVID-19 predominantly affects the respiratory system, it has become apparent that many other organ systems can also be involved. Imaging plays an essential role in the diagnosis of all manifestations of the disease and its related complications, and proper utilization and interpretation of imaging examinations is crucial. A comprehensive understanding of the diagnostic imaging hallmarks, imaging features, multisystem involvement, and evolution of imaging findings is essential for effective patient management and treatment. In part 1 of this article, the authors described the viral pathogenesis, diagnostic imaging hallmarks, and manifestations of the pulmonary and peripheral and central vascular systems of COVID-19. In part 2 of this article, the authors focus on the key imaging features of the varied pathologic manifestations of COVID-19, involving the cardiac, neurologic, abdominal, dermatologic and ocular, and musculoskeletal systems, as well as the pediatric and pregnancy-related manifestations of the virus. Online supplemental material is available for this article. ©RSNA, 2020.


Assuntos
Infecções por Coronavirus/complicações , Infecções por Coronavirus/diagnóstico por imagem , Pneumonia Viral/complicações , Pneumonia Viral/diagnóstico por imagem , Adolescente , Adulto , Idoso , Doenças Assintomáticas , Betacoronavirus , Encéfalo/diagnóstico por imagem , Sistema Cardiovascular/diagnóstico por imagem , Criança , Infecções por Coronavirus/diagnóstico , Feminino , Trato Gastrointestinal/diagnóstico por imagem , Humanos , Recém-Nascido , Pulmão/diagnóstico por imagem , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Pandemias , Pneumonia Viral/diagnóstico , Gravidez , Complicações Infecciosas na Gravidez/diagnóstico por imagem , Radiografia , Avaliação de Sintomas , Tomografia Computadorizada por Raios X
5.
Kardiologiia ; 60(7): 72-77, 2020 Aug 11.
Artigo em Russo | MEDLINE | ID: mdl-33155943

RESUMO

Aim To analyze a tendency in circulatory system diseases (CSD) in the Kyrgyz Republic (KR).Materials and methods Medical statistics on morbidity, prevalence, mortality, and primary disability related with CSD in the adult population was obtained from the National Health Information Center (NHIC) of the Ministry of Health of the KR and the National Statistical Committee of the KR. For the purpose of comparative analysis, relative values were calculated per 100,000 and 10,000 population. A retrospective epidemiological study of prevalence, morbidity, mortality, and primary disability related with CSD for 2002-2017 was performed with calculation of the increase/decrease rate using the least square method for aligning the dynamic row. Also, the epidemiological situation of CSD was analyzed by sex and in 9 administrative divisions of the KR with calculation of the mean long-term incidence (MLTI) of CSD from 2007 through 2017. Statistical analysis was performed with specialized Statistica 10.0 and SPSS 11.5 software.Results CSD remain the major cause of death (51.6 % in 2017) and primary disability (19.68 % of overall primary disability) in the Kyrgyz population. Prevalence of CSD shows a pronounced upward trend (6.8% increment rate relative to 2002) whereas the incidence rate has increased with a moderate trend (3.5 % increment rate). The major structure of CSD is determined by essential hypertension (51.2 %), ischemic heart disease (28.0 %), and cerebrovascular diseases (10.0 %). CSD is more frequently observed in women (mean value for 2007-2017, 59.0%) than in men (41.0 %) (р<0.001). Mean long-term indexes of CSD significantly differ in different regions and cities of the KR. The highest primary morbidity and prevalence of CSD is observed in Bishkek (1546.90 / 0000 and 12415.40 / 0000). Relatively low levels of these values are found in the Talas Region (720.70 / 0000 and 3675.10 / 0000, respectively).Conclusion CSD remains the major cause of death and primary disability in the population of the KR. Prevalence of CSD shows a pronounced increasing trend whereas the increase in incidence rate is moderate. The major structure of CSD is determined by essential hypertension, ischemic heart disease, and cerebrovascular diseases. Incidence of CSD is statistically significantly higher for women than for men. Mean long-term indexes of CSD significantly differ in different regions and cities of the KR. Therefore, it is essential to enhance preventive measures in the KR; to identify individuals with hypertension at the level of primary care; and to motivate healthcare professionals to improve the quality of healthcare (CSD prevention, detection, and treatment).


Assuntos
Doenças Cardiovasculares , Sistema Cardiovascular , Adulto , Doenças Cardiovasculares/epidemiologia , Feminino , Humanos , Quirguistão/epidemiologia , Masculino , Morbidade , Estudos Retrospectivos
6.
Kardiologiia ; 60(9): 62-67, 2020 Oct 14.
Artigo em Russo | MEDLINE | ID: mdl-33131476

RESUMO

Aim        To study temporal and spectral characteristics of heart rhythm variability (HRV) in night shift workers.Materials and methods       Along with traditional risk factors, conditions of labor contribute to development of cardiovascular morbidity, including night shift work, which can be associated with disorders of the autonomic regulation detected by analysis of HRV. This study included 100 healthy men. 74 of them were engaged in shift work, including 53 men with rotating shift work, 21 men with fixed night shifts, and 26 men with day-time work. HRV was analyzed by data of 5-min electrocardiogram recording (background recording and orthostatic test).Results   Night-shift workers had decreases in total power of regulation (ТР, SDNN) and in the parasympathetic branch (HF, pNN50). Rotating night-shift workers displayed significant decreases in SDNN and pNN50 and pronounced changes in the VLF / LF / HF ratio in the orthostatic test.Conclusion            In work with night shifts, the type of autonomic regulation differs from the "standard" functioning of the autonomic nervous system (ANS). This study showed different effects of night work regimens on HRV indexes. With the rotating shift work, the ANS dysregulation was more profound and was evident by a significant decrease in the ANS total tone and parasympathetic activity (SDNN, pNN50) compared to night shifts with fixed working hours. The excessive weakening of the parasympathetic component in the passive orthostatic test can be considered as an early marker for ANS maladaptation.


Assuntos
Sistema Cardiovascular , Ritmo Circadiano , Sistema Nervoso Autônomo , Eletrocardiografia , Frequência Cardíaca , Humanos , Masculino
7.
Arq Bras Cardiol ; 115(4): 660-666, 2020 10.
Artigo em Inglês, Português | MEDLINE | ID: mdl-33111866

RESUMO

BACKGROUND: COVID-19 causes severe pulmonary involvement, but the cardiovascular system can also be affected by myocarditis, heart failure and shock. The increase in cardiac biomarkers has been associated with a worse prognosis. OBJECTIVES: To evaluate the prognostic value of Troponin-T (TNT) and natriuretic peptide (BNP) in patients hospitalized for Covid-19. METHODS: This was a convenience sample of patients hospitalized for COVID-19. Data were collected from medical records to assess the association of TnT and BNP measured in the first 24 hours of hospital admission with the combined outcome (CO) of death or need for mechanical ventilation. Univariate analysis was used to compare the groups with and without the CO. Cox's multivariate model was used to determine independent predictors of the CO. RESULTS: We evaluated 183 patients (age = 66.8±17 years, 65.6% of which were males). The time of follow-up was 7 days (range 1 to 39 days). The CO occurred in 24% of the patients. The median troponin-T and BNP levels were 0.011 and 0.041ng/dL (p <0.001); 64 and 198 pg/dL (p <0.001), respectively, for the groups without and with the CO. In the univariate analysis, in addition to TnT and BNP, age, presence of coronary disease, oxygen saturation, lymphocytes, D-dimer, t-CRP and creatinine, were different between groups with and without outcomes. In the bootstrap multivariate analysis, only TnT (1.12 [95% CI 1.03-1.47]) and t-CRP (1.04 [95% CI 1.00-1.10]) were independent predictors of the CO. CONCLUSION: In the first 24h of admission, TnT, but not BNP, was an independent marker of mortality or need for invasive mechanical ventilation. This finding further reinforces the clinical importance of cardiac involvement in COVID-19. (Arq Bras Cardiol. 2020; 115(4):660-666).


Assuntos
Infecções por Coronavirus/diagnóstico , Peptídeo Natriurético Encefálico/sangue , Pneumonia Viral/diagnóstico , Troponina T/sangue , Idoso , Idoso de 80 Anos ou mais , Betacoronavirus , Biomarcadores/sangue , Sistema Cardiovascular/fisiopatologia , Sistema Cardiovascular/virologia , Infecções por Coronavirus/mortalidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pandemias , Pneumonia Viral/mortalidade , Prognóstico
8.
Internist (Berl) ; 61(11): 1140-1150, 2020 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-33025125

RESUMO

BACKGROUND: Malignant diseases lead to a decline in physical performance in a large number of patients. This includes a reduction of the musculoskeletal system, restrictions in cardiovascular fitness and psychogenically influenced syndromes such as fatigue and asthenia. It is not yet clear to what extent physical training can counteract these limitations or undesirable side effects and how this training needs to be designed in the individual situation. AIM OF THIS ARTICLE: The aim of this article is to find out whether physical training can be performed in cancer patients, how this training should be designed and which physical disorders can be influenced favorably. MATERIALS AND METHODS: In this review, the currently available work on this topic was evaluated and classified with regard to its feasibility and effects in cancer patients. RESULTS AND DISCUSSION: Physical training can be performed without complications in most patients even under treatment for the underlying malignant disease. It has a positive effect on physical performance, cardiovascular function, the perception of one's own cancer and overall well-being. Ideally, physical training for cancer patients should include a mixture of strength and endurance training. It should be carried out regularly and its intensity should be slowly increased. The type of physical activity should be adapted to the individual needs of the patient, take into account the particularities of the malignant disease and exclude any risk to the patient. CONCLUSION: In summary, a physical training program to accompany cancer therapy should be offered to virtually all patients with malignant disease.


Assuntos
Antineoplásicos/efeitos adversos , Exercício Físico , Neoplasias/tratamento farmacológico , Aptidão Física , Esportes , Antineoplásicos/uso terapêutico , Sistema Cardiovascular , Humanos , Oncologia , Neoplasias/psicologia , Resistência Física/fisiologia , Qualidade de Vida
9.
Internist (Berl) ; 61(11): 1120-1124, 2020 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-33052455

RESUMO

As a result of the continuous development of modern cancer treatment, more cancer patients can be cured every year. However, since many patients experience cardiovascular problems before, during and after their cancer treatment, cardio-oncology is becoming increasingly important. Numerous therapies can cause cardiotoxicity, such as chemotherapy, immunotherapy, antibody therapy and radiotherapy. If these remain undetected, the patient may develop, e.g. heart failure or severe heart valve damage. The broad spectrum of cardiovascular comorbidities has become an immense challenge for cardiologists and oncologists. Cardio-oncology also deals with the effects that cancer has on the cardiovascular system. New research indicates that the tumor itself also has direct negative effects on the heart, mediated by messenger substances. Therefore, it is important to understand which cancer patients are at increased cardiovascular risk, thereby enabling the development of new therapeutic approaches in the long term to maintain mobility and improve patient prognosis.


Assuntos
Antineoplásicos/efeitos adversos , Cardiotoxicidade , Sistema Cardiovascular/efeitos dos fármacos , Cardiopatias/induzido quimicamente , Coração/efeitos dos fármacos , Neoplasias/tratamento farmacológico , Antineoplásicos/uso terapêutico , Humanos , Oncologia
10.
Cardiovasc Ther ; 2020: 4354759, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33042223

RESUMO

To investigate whether specific time series patterns for blood pressure (BP), heart rate (HR), and sympathetic tone are associated with metabolic factors and the 10-year risk of atherosclerotic cardiovascular disease (ASCVD). A total of 989 patients who underwent simultaneous 24-hour ambulatory BP and Holter electrocardiogram monitoring were enrolled. The patients were categorized into sixteen groups according to their circadian patterns using the consensus clustering analysis method. Metabolic factors, including cholesterol profiles and apolipoprotein, were compared. The 10-year ASCVD risk was estimated based on the Framingham risk model. Overall, 16 significant associations were found between the clinical variables and cluster groups. Age was commonly associated with all clusters in systolic BP (SBP), diastolic BP (DBP), HR, and sympathetic tone. Metabolic indicators, including diabetes, body mass index, total cholesterol, high-density lipoprotein, and apolipoprotein, were associated with the four sympathetic tone clusters. In the crude analysis, the ASCVD risk increased incrementally from clusters 1 to 4 across SBP, DBP, HR, and sympathetic tone. After adjustment for multiple variables, however, only sympathetic tone clusters 3 and 4 showed a significantly high proportion of patients at high risk (≥7.5%) of 10-year ASCVD (odds ratio (OR) = 5.90, 95% confidential interval (CI) = 1.27-27.46, and P value = 0.024 and OR = 15.28, 95% CI = 3.59-65.11, and P value < 0.001, respectively). Time series patterns of BP, HR, and sympathetic tone can serve as an indicator of aging. Circadian variations in sympathetic tone can provide prognostic information about patient metabolic profiles and indicate future ASCVD risk.


Assuntos
Pressão Sanguínea , Doenças Cardiovasculares/fisiopatologia , Sistema Cardiovascular/inervação , Ritmo Circadiano , Frequência Cardíaca , Adulto , Idoso , Biomarcadores/sangue , Monitorização Ambulatorial da Pressão Arterial , Doenças Cardiovasculares/sangue , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/epidemiologia , Análise por Conglomerados , Eletrocardiografia Ambulatorial , Metabolismo Energético , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Fatores de Risco , Seul/epidemiologia , Fatores de Tempo
12.
Medicine (Baltimore) ; 99(40): e22575, 2020 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-33019471

RESUMO

RATIONALE: Giant intra-abdominal liposarcomas weighing over 20 kg often increase the intra-abdominal pressure (IAP), which has severe effects on the cardiovascular and respiratory systems. Abdominal compartment syndrome is defined typically as the combination of a raised IAP of 20 mm Hg or higher and new onset of organ dysfunction or failure. The anesthetic management and perioperative management are very challenging. PATIENTS CONCERNS: We presented 2 patients with rare giant growing liposarcoma of the abdomen, weighing 21 kg and over 35 kg, respectively. Circulatory management was particularly difficult in the first case, while respiratory management and massive blood loss was very challenging in the second one. DIAGNOSIS: With a computed tomography scan and peritoneal-to-abdominal height ratio measurement, preoperatively the risk of developing intra-abdominal hypertension and abdominal compartment syndrome was recognized early in each patient. The inferior vena cava and right atrium of the first patient was compressed and malformed due to the uplifted diaphragm, while there was severe decreased lung volume and increased airway resistance, because of rare giant retroperitoneal liposarcomas in the second case. Histologic examination revealed dedifferentiated liposarcoma in both cases. INTERVENTIONS: Both of the patients underwent resection surgery with multiple monitoring; transesophageal echocardiography monitoring in the first case and pressure-controlled ventilation volume guaranteed mechanical ventilation mode in both cases. OUTCOMES: Intraoperatively and postoperatively no cardiopulmonary complications in both patients. The first patient was discharged without any complications on postoperative day 10, and the second patient underwent another surgery because of anastomotic leakage resulting from bowel resection. LESSONS: Multiple monitorings, in particular transesophageal echocardiography should be considered in patients with increased IAP due to a giant mass, while an appropriate lung protection ventilation strategy is crucial in these patients.


Assuntos
Hipertensão Intra-Abdominal/fisiopatologia , Lipossarcoma/complicações , Lipossarcoma/cirurgia , Neoplasias Retroperitoneais/complicações , Neoplasias Retroperitoneais/cirurgia , Adulto , Assistência ao Convalescente , Resistência das Vias Respiratórias/fisiologia , Fístula Anastomótica/cirurgia , Perda Sanguínea Cirúrgica , Sistema Cardiovascular/fisiopatologia , Ecocardiografia Transesofagiana/métodos , Feminino , Humanos , Cuidados Intraoperatórios/métodos , Cuidados Intraoperatórios/estatística & dados numéricos , Lipossarcoma/diagnóstico por imagem , Lipossarcoma/patologia , Masculino , Pessoa de Meia-Idade , Monitorização Fisiológica/normas , Respiração Artificial/métodos , Neoplasias Retroperitoneais/diagnóstico por imagem , Neoplasias Retroperitoneais/patologia , Resultado do Tratamento
13.
Herz ; 45(7): 659-662, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33025029

RESUMO

The clinical manifestations of COVID-19 are mainly respiratory symptoms, but some patients present with cardiovascular system disease such as palpitations and shortness of breath as the first or secondary symptoms. In this paper, we describe the characteristics of SARS-CoV­2 and its functional receptor angiotensin-converting enzyme 2 (ACE2). Furthermore, we explore the impact of virus-induced myocardial damage, decreased ACE2 activity, immune imbalance, hypoxemia, and heart damage caused by antiviral drugs.


Assuntos
Betacoronavirus/patogenicidade , Sistema Cardiovascular/fisiopatologia , Infecções por Coronavirus/fisiopatologia , Peptidil Dipeptidase A , Pneumonia Viral/fisiopatologia , Sistema Cardiovascular/virologia , Humanos , Pandemias
14.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 702-705, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018084

RESUMO

Diverse analysis techniques have been used to comprehend the regulation by the autonomic nervous system (ANS) of the cardiovascular system when a human being faces a stressor. Recently, however, the complete ensemble empirical mode decomposition (EMD) with adaptive noise (CEEMDAN) allows analyzing nonstationary signals in a nonlinear and time- variant way. Consequently, CEEMDAN may provide a means to obtain clues about ANS regulation in health and disease. In this study, we analyze the average Hilbert-Huang spectrum (HHS) of cardiovascular variability signals by CEEMDAN during a head-up tilt test (HUTT) in 12 healthy female subjects and 18 orthostatic intolerance female patients. Beat-to-beat intervals (BBI) as well as systolic (SYS) blood pressure variability time series were analyzed. In addition, instantaneous amplitudes and frequencies of specific intrinsic mode functions (IMF) were investigated separately to define the influence of the disease on ANS regulation. Female groups demonstrated statistical differences in the high-frequency band of BBI but higher differences for the high and low-frequency bands of SYS from the mechanical transition of HUTT.Clinical Relevance- A relevant outcome of the study is the average HHS of healthy female subjects along HUTT. This HHS may be used as reference to help diagnose OI when HHS of the cardiovascular variability signals of any subject deviates from the normal course.


Assuntos
Sistema Cardiovascular , Intolerância Ortostática , Sistema Nervoso Autônomo , Feminino , Humanos , Posição Ortostática , Teste da Mesa Inclinada
15.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 710-713, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018086

RESUMO

Recent developments of detrended fluctuation analysis (DFA) provide multifractal/multiscale (MFMS) descriptions of the heart rate self-similarity, a promising approach to cardiovascular complexity. However, it is unclear whether the MFMS DFA may also describe the nonlinear components of heart rate variability. Our aim is to define MFMS DFA indices for quantifying the short-term and long-term degree of the heart-rate nonlinearity and to apply these indices to detect possible sex-related differences.We recorded the inter-beat-interval (IBI) series in 42 male and in 42 female healthy participants sitting at rest for about 2 hours. For each series j, we generated 100 phase-randomized surrogate series. We applied the MFMS DFA to estimate the self-similarity coefficients α over scales τ between 8 and 512 s and moment orders q between -5 and +5, obtaining coefficients for the original series, αO,j (q, τ), and for each surrogate, αi,j (q, τ) with 1≤i≤100. We first evaluated πj(q, τ), percentile of αi,j (q, τ) distribution in which was αO,j (q, τ). Then we calculated the percentages of scales where πj(q, τ) was <5% for 8≤τ≤16 s (short-term nonlinearity index NL1(q)) and for 16≤τ≤512 s (long-term nonlinearity index NL2(q)). We found that NL1(q) was generally greater than 50% at all q≥0 but q=2 (i.e., moment order of the monofractal DFA), while at q<0 it was high in males only, with significant sex differences at q=-1 and q=-2. Results indicate that the multifractal DFA may highlight nonlinear heart-rate components at the short scales that are not revealed by the traditional monofractal DFA and that appear related to gender differences.Clinical Relevance- This supports the use of MFMS DFA to integrate the linear information from traditional spectral methods of heart rate variability in clinical studies aimed at improving the stratification of the cardiovascular risk.


Assuntos
Sistema Cardiovascular , Caracteres Sexuais , Algoritmos , Feminino , Frequência Cardíaca , Humanos , Masculino , Postura Sentada
16.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1080-1083, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018173

RESUMO

Cerebral vascular territories are related to the clinical progression and outcome of ischemic stroke. The vascular territory map (VTM) helps to understand stroke pathophysiology and potentially the clinical prognosis. A VTM can be generated from the bolus arrival time map. However, previous methods require initial seed points to be chosen manually, and the region inferior to the circle of Willis is not included. In this paper, we propose a method to automatically generate a map of the whole cerebral vascular territory from CT perfusion imaging. We applied the proposed method to 19 cases of ischemic stroke to generate VTM for each case.Clinical Relevance- The proposed map may improve the interpretation of the physiological status of collateral flow for ischemic stroke, and aid in treatment decision making.


Assuntos
Isquemia Encefálica , Sistema Cardiovascular , Acidente Vascular Cerebral , Encéfalo/diagnóstico por imagem , Isquemia Encefálica/diagnóstico por imagem , Mapeamento Encefálico , Humanos , Acidente Vascular Cerebral/diagnóstico por imagem
17.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 2569-2572, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018531

RESUMO

We assessed the effect of surgical aortic valve replacement (SAVR) on cardiovascular and cerebrovascular controls with particular attention to their complexity and presence of nonlinear behaviors via the analysis of spontaneous variability of heart period (HP), systolic and diastolic arterial pressure (SAP and DAP) and mean cerebral blood flow (MCBF). Variability series were acquired before (PRE) and after (POST) SAVR in 12 patients (age: 76±4.7 yrs, 7 males) at rest in supine position and during active standing. Complexity was assessed via a local nonlinear prediction approach exploiting the k-nearest neighbor strategy. The presence of nonlinear dynamics was checked by comparing the complexity marker computed over the original series with the distribution of values assessed over 100 surrogates preserving distribution and power spectral density of the original series but with random phases. We found that: i) HP variance was significantly reduced in POST; ii) the complexity of SAP and DAP variabilities increased in POST with a greater likelihood of observing nonlinear dynamics over SAP compared to PRE at supine rest; iii) the amplitude of MCBF fluctuations and its complexity in POST remained similar to PRE. SAVR induces important changes of the cardiac and vascular autonomic controls, while cerebrovascular regulation seems to be less affected.


Assuntos
Valva Aórtica , Sistema Cardiovascular , Idoso , Idoso de 80 Anos ou mais , Valva Aórtica/cirurgia , Sistema Nervoso Autônomo , Pressão Sanguínea , Frequência Cardíaca , Humanos , Masculino
18.
Nihon Yakurigaku Zasshi ; 155(5): 300-302, 2020.
Artigo em Japonês | MEDLINE | ID: mdl-32879169

RESUMO

Disease-specific iPS cells have been considered and used as platforms for disease modeling and drug discovery for intractable diseases. In the field of cardiovascular medicine, iPS cells have been generated from patients with heart diseases including inherited cardiomyopathy. The disease-specific iPS cells showed the certain parts of phenotype of the disease on culture dishes in in vitro systems, but the cells do not necessarily recapitulate patients' clinical properties, particularly those of physiological-/pathophysiological aspects. The point should be solved to establish disease reliable platforms. The discrepancy may be attributed to the lack of developmental process during culture procedure. To settle the problems, various techniques have been attempted such as culture dishes with specific structures. This review describes issues to be solved to recapitulate "heart diseases on culture dishes", introducing the phenotype of disease specific iPS-cells from patients with cardiomyopathy.


Assuntos
Cardiomiopatias , Sistema Cardiovascular , Células-Tronco Pluripotentes Induzidas , Diferenciação Celular , Descoberta de Drogas , Humanos , Fenótipo
19.
Diving Hyperb Med ; 50(3): 273-277, 2020 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-32957130

RESUMO

The South Pacific Underwater Medicine Society (SPUMS) diving medical for recreational scuba divers was last reviewed in 2011. From 2011 to 2019, considerable advancements have occurred in cardiovascular risk assessment relevant to divers. The SPUMS 48th (2019) Annual Scientific Meeting theme was cardiovascular risk assessment in diving. The meeting had multiple presentations updating scientific information about assessing cardiovascular risk. These were distilled into a new set of guidelines at the final conference workshop. SPUMS guidelines for medical risk assessment in recreational diving have subsequently been updated and modified including a new Appendix C: Suggested evaluation of the cardiovascular system for divers. The revised evaluation of the cardiovascular system for divers covers the following topics: 1. Background information on the relevance of cardiovascular risk and diving; 2. Defining which divers with cardiovascular problems should not dive, or whom require treatment interventions before further review; 3. Recommended screening procedures (flowchart) for divers aged 45 and over; 4. Assessment of divers with known or symptomatic cardiovascular disease, including guidance on assessing divers with specific diagnoses such as hypertension, atrial fibrillation, cardiac pacemaker, immersion pulmonary oedema, takotsubo cardiomyopathy, hypertrophic cardiomyopathy and persistent (patent) foramen ovale; 5. Additional cardiovascular health questions included in the SPUMS guidelines for medical risk assessment in recreational diving; 6. Updated general cardiovascular medical risk assessment advice; 7. Referencing of relevant literature. The essential elements of this guideline are presented in this paper.


Assuntos
Doenças Cardiovasculares , Sistema Cardiovascular , Mergulho , Doenças Cardiovasculares/diagnóstico , Mergulho/efeitos adversos , Humanos , Pessoa de Meia-Idade , Medição de Risco , Fatores de Risco
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