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1.
Transl Vis Sci Technol ; 11(5): 2, 2022 May 02.
Artigo em Inglês | MEDLINE | ID: mdl-35506930

RESUMO

Purpose: In femtosecond laser-assisted cataract surgery (FLACS), capsulorhexis can be performed with an ophthalmic viscosurgical device (OVD) filled in the anterior chamber. We aimed to investigate changes in the laser properties in various optical aspects, such as focal shifting, reflection, and absorption associated with OVD. Methods: Simulation was achieved by calculating the laser power attenuation due to reflection and spot size change using the Gullstrand eye model. Additionally, we calculated the absorption coefficient by measuring the laser power passing through the OVD with a laser meter and evaluated the effect of absorption by the OVD. Results: In our simulation, power attenuation due to reflection was a maximum of 0.07%, and power attenuation was 0.08% even when considering the change according to the incident angle. Power attenuation due to the change of the spot size at the focus was 0.005%. Owing to the absorption of the OVD, a power increase of up to 13.5% was required for an anterior chamber depth of 3.0 mm to obtain the same effect as the aqueous humor. Conclusions: The main reason for laser power attenuation associated with OVD was laser absorption through the OVD, and could also be caused by laser cavitation bubbles. To complete a safe capsulotomy during FLACS, the laser power should be increased appropriately, considering the absorption by the OVD in the anterior chamber. Translational Relevance: The study results can be applied to calculate the optimal femtosecond laser energy to achieve complete capsulotomy during FLACS in the presence of anterior chamber OVD.


Assuntos
Extração de Catarata , Catarata , Terapia a Laser , Capsulorrexe/métodos , Catarata/complicações , Extração de Catarata/métodos , Humanos , Terapia a Laser/métodos , Lasers
3.
Medicina (Kaunas) ; 58(4)2022 Apr 04.
Artigo em Inglês | MEDLINE | ID: mdl-35454351

RESUMO

Background and Objectives: Insufficient connective urethra and bladder support related to childbirth and menopausal estrogen decrease leads to stress urinary incontinence (SUI). The aim of this review is to narratively report the efficacy and safety of new mini-invasive solutions for SUI treatment as laser energy devices, in particular, the microablative fractional carbon dioxide laser and the non-ablative Erbium-YAG laser. Materials and Methods: For this narrative review, a search of literature from PubMed and EMBASE was performed to evaluate the relevant studies and was limited to English language articles, published from January 2015 to February 2022. Results: A significant subjective improvement, assessed by the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-UI-SF) was reported at the 6-month follow up, with a cure rate ranged from 21% to 38%. A reduction of effect was evidenced between 6 and 24-36 months. Additionally, the 1-h pad weight test evidence a significant objective improvement at the 2-6-month follow up. Conclusions: SUI after vaginal laser therapy resulted statistically improved in almost all studies at short-term follow up, resulting a safe and feasible option in mild SUI. However, cure rates were low, longer-term data actually lacks and the high heterogeneity of methods limits the general recommendations. Larger RCTs evaluating long-term effects are required.


Assuntos
Terapia a Laser , Lasers de Estado Sólido , Terapia com Luz de Baixa Intensidade , Incontinência Urinária por Estresse , Feminino , Humanos , Lasers de Estado Sólido/uso terapêutico , Masculino , Resultado do Tratamento , Incontinência Urinária por Estresse/cirurgia
4.
Sensors (Basel) ; 22(8)2022 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-35458942

RESUMO

Fluorescence is the most sensitive spectroscopic method of analysis and fluorescence methods. However, classical analysis requires sampling. There are new needs for real-time analyses of biological materials, without the need for sampling. This article presents examples of proprietary applications of laser-induced fluorescence (LIF) in medicine with such methods. A classic example is the analysis of photosensitizers using the photodynamic treatment method (PDT). The level and kinetics of accumulation and excretion of sensitizers in the body are examined, as well as the optimal exposure time after the application of compounds. The LIF method is also used to analyze endogenous fluorophores; it has been used to detect neoplasms, e.g., lung cancer or gynecological and dermatological diseases. Furthermore, it is used for the diagnosis of early stages of tooth decay or detection of fungi. The article will present the construction of sensors based on the LIF method-fiber laser spectrometers and investigated fluorescence spectra in individual applications. Examples of fluorescence imaging, e.g., dermatological, and dental diagnostics and measuring systems will be presented. The advantage of the method is it has greater sensitivity and easily detects lesions early compared to the methods used in observing the material in reflected light.


Assuntos
Terapia a Laser , Neoplasias , Fluorescência , Humanos , Lasers , Imagem Óptica , Análise Espectral
5.
Artigo em Inglês | MEDLINE | ID: mdl-35457467

RESUMO

Actinic cheilitis (AC) is a chronic inflammation of the lip considered an oral, potentially malignant disorder associated with an increased risk of lip squamous cell carcinoma (SCC) development. Controversies surrounding current therapeutic modalities of AC are under debate, and the implications of laser treatment have not been specifically investigated through a systematic review design. The present study aims to evaluate the degree of evidence of laser for the treatment of AC in terms of efficacy and safety. We searched for primary-level studies published before January 2022 through MEDLINE/PubMed, Embase, Web of Science, Scopus and CENTRAL, with no limitation in publication language or date. We evaluated the methodological quality and risk of bias of the studies included using the updated Cochrane Collaboration's tool for assessing risk of bias (RoB-2). Twenty studies (512 patients) met our eligibility criteria. Laser therapy showed a complete clearance of AC in 92.5% patients, with a maximum recurrence rate of 21.43%, and a very low frequency of malignant transformation to SCC (detected in only 3/20 studies analyzed). In addition, cosmetic outcomes and patient satisfaction were described as excellent. In conclusion, our findings indicate that laser therapy is a high efficacy approach to AC.


Assuntos
Queilite , Terapia a Laser , Carcinoma de Células Escamosas/etiologia , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/terapia , Queilite/complicações , Queilite/patologia , Queilite/terapia , Humanos , Neoplasias Labiais/etiologia , Neoplasias Labiais/patologia , Neoplasias Labiais/terapia
6.
Artigo em Russo | MEDLINE | ID: mdl-35485661

RESUMO

Along with the classical methods of surgical treatment of rectal fistulas, new minimally invasive technologies have appeared using video endoscopic support for processing the fistulous tract and closing the internal fistula opening, intrasphincter ligation of the fistulous tract LIFT, however, they do not exclude relapses in the late postoperative period. The FiLaC (Fistula Laser Closure) laser technology based on the use of a radial flexible laser light guide, which does not cause damage to the anal canal mucosa, pain in the postoperative period, rectal postoperative bleeding and strictures, is quite promising in the further development of outpatient minimally invasive surgery for anal fistulas. anal canal. However, even with this technique, complications and relapses were observed in 10-12% of cases, which dictates the need to develop not only a patient-oriented approach to the surgical treatment of patients with chronic paraproctitis, but also to develop postoperative rehabilitation programs in the early postoperative period. OBJECTIVE: To study the effect of complex rehabilitation programs used in the early postoperative period on the efficacy of the therapy in patients with pararectal fistulas. MATERIAL AND METHODS: The study included 90 patients with chronic paraproctitis, (the average age was 43±3.4 years, the average duration of the disease was 5.1±1.5 years), who underwent a surgery using the modified FiLac technology. The patients were divided into 3 groups (30 patients in each group) depending on the rehabilitation method used during the postoperative period (2 days after the surgery): 1st group underwent a 4-component rehabilitation complex (intravenous ozone therapy, rectal laser therapy, recto-tibialmyostimulation of the pelvic floor muscles and biofeedback therapy); 2nd group underwent a 2-component rehabilitation complex (intravenous ozone therapy and rectal laser therapy); 3rd group has received a standard medical complex, which served as a background in 1st group and 2nd group. Therapeutic efficacy was assessed according to the assessment of pain syndrome (on the VAS scale), the results of anal sphincterometry (the Peritron 9600 device), the incidence of postoperative complications and relapses at different follow-up periods (up to 5 years). RESULTS: A comparative analysis of the nature of the course of the postoperative period, depending on the type of postoperative rehabilitation was carried out. In multiple comparisons using the parametric ANOVA method, it was found that there were statistically significant differences between the 1st group and the 3rd group in terms of pain intensity, duration of pain, the timing of wound healing, the frequency of complications, and the timing of return to work. The results in the 2nd group were slightly lower than in the 1st group, but they also differed significantly from the data of the 3rd group. During the analysis of the early and late p/o complications and relapses in patients with chronic paraproctitis after surgery the most significant were obtained from the 1st group (only 1 case of early p/o complications and relapse within 1 to 5 years), while in the 3rd group there were 2 (6.6%) cases of early p/o complications, 2 cases (6.6%) of relapses within a period of up to 1 year and 6 (20%) cases in the period from 1 to 5 years. In patients of the 2nd group, results close to the results of the 1st group were obtained: 2 (6.6%), 2 (6.6%) and 3 (9.9%) cases respectively. CONCLUSION: The use of expanded rehabilitation complexes among the patients with chronic paraproctitis in the early postoperative period after surgery, including intravenous ozone therapy, rectal laser therapy, recto-tibialmyostimulation and bifidobac therapy, made it possible to significantly improve therapeutic efficacy, which was confirmed by faster pain relief, fewer early and late p/o complications. The data obtained indicate the need for the use of rehabilitation programs in the early postoperative period for the treatment and prevention of complications after surgery.


Assuntos
Proctite/reabilitação , Fístula Retal , Adulto , Doença Crônica , Humanos , Terapia a Laser , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos , Ozônio/uso terapêutico , Dor Pós-Operatória/etiologia , Dor Pós-Operatória/prevenção & controle , Período Pós-Operatório , Fístula Retal/complicações , Fístula Retal/diagnóstico por imagem , Fístula Retal/cirurgia , Recidiva
7.
BMJ Open ; 12(4): e060815, 2022 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-35450918

RESUMO

BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, painful, inflammatory skin disease with estimates of prevalence in the European population of 1%-2%. Despite being a relatively common condition, the evidence base for management of HS is limited. European and North American management guidelines rely on consensus for many aspects of treatment and within the UK variations in management of HS have been identified. The HS James Lind Alliance Priority Setting Partnership (PSP) published a top 10 list of future HS research priorities including both medical and surgical interventions. The aims of the THESEUS study are to inform the design of future HS randomised controlled trials (RCTs) and to understand how HS treatments are currently used. THESEUS incorporates several HS PSP research priorities, including investigation of oral and surgical treatments. Core outcome domains have been established by the HIdradenitis SuppuraTiva cORe outcomes set International Collaboration (HISTORIC) and THESEUS is designed to validate instruments to measure the domains. METHODS AND ANALYSIS: The THESEUS study is a prospective observational cohort study. Participants, adults with active HS of any severity, will be asked to select one of five HS treatment options that is appropriate for their HS care. Participants will be allocated to their chosen treatment intervention and followed for a period of up to 12 months. Outcomes will be assessed at 3-monthly intervals using HISTORIC core outcome instruments. Video recordings of the surgical and laser operations will provide informational and training videos for future trials. Nested mixed-methods studies will characterise the interventions in clinical practice, understand facilitators and barriers to recruitment into future HS RCTs and examine patients' and clinicians' perspectives on HS treatment choices. TRIAL REGISTRATION NUMBER: ISRCTN69985145.


Assuntos
Hidradenite Supurativa , Terapia a Laser , Adulto , Estudos de Coortes , Hidradenite Supurativa/terapia , Humanos , Estudos Observacionais como Assunto
8.
J Ocul Pharmacol Ther ; 38(4): 311-318, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35442770

RESUMO

Purpose: To assess the intraocular pressure (IOP)-lowering effect of a biodegradable bimatoprost implant following selective laser trabeculoplasty (SLT) in a canine model. Methods: Unilateral SLT was performed in 11 normotensive, treatment-naive beagle dogs. IOP was measured at baseline (pre-SLT) and weekly post-SLT (≤10 weeks). After IOP returned to baseline or at 10 weeks (whichever occurred first), a sustained-release bimatoprost implant was administered bilaterally in the anterior chamber of each animal. IOP was measured weekly for 4 weeks and then every 2 weeks up to week 42. Results: The main outcomes included the IOP change (%) from baseline, calculated in both eyes in the overall population, SLT responder subgroup (defined by peak IOP reduction from baseline ≥3 mmHg or ≥15% for >1 week post-SLT), and SLT nonresponder subgroup (defined by peak IOP reduction from baseline <3 mmHg or <15%). The bimatoprost implant lowered IOP similarly in both the SLT-treated and fellow SLT-naive eyes. Following bimatoprost implant administration, the mean (standard deviation [SD]) peak IOP reduction from baseline was 34.4% (8.5%) in SLT-treated eyes and 35.7% (5.9%) in fellow SLT-naive eyes. The bimatoprost implant lowered IOP comparably (P > 0.17) in eyes that responded to SLT (mean [SD] peak IOP reduction, 34.6% [10.7%]; n = 6) and those that did not (mean [SD] peak IOP reduction, 34.1% [6.1%]; n = 5). Conclusion: The bimatoprost implant effectively lowered IOP in eyes pretreated with SLT, regardless of response to SLT. The current data suggest that eyes previously treated with SLT can still benefit from the intracameral bimatoprost implant.


Assuntos
Terapia a Laser , Hipertensão Ocular , Trabeculectomia , Animais , Bimatoprost/farmacologia , Bimatoprost/uso terapêutico , Preparações de Ação Retardada , Cães , Pressão Intraocular , Lasers , Resultado do Tratamento
9.
Artigo em Russo | MEDLINE | ID: mdl-35485655

RESUMO

The high prevalence of the combination of arterial hypertension (AH) with coronary heart disease (CHD) suggests the improvement of their treatment methods. In this regard, it is of interest to assess the dynamics of the clinical picture of patients against the background of pathogenetically determined subcellular and systemic changes under the influence of laser therapy (LT). OBJECTIVE: To evaluate the clinical effect of LT in patients with hypertension in combination with coronary artery disease and trace its relationship with the dynamics of the structure of the lipid bilayer of the erythrocyte membrane and changes in the microvascular bed. MATERIAL AND METHODS: We examined 65 male patients (mean age 50.9±6.3 years) with II-III degree AH in combination with coronary artery disease with angina pectoris. Among them, 40 patients received a 10-day course of LT, and 25 patients underwent simulated laser irradiation. At the initial stage and after 1 month, all patients underwent a bicycle exercise test, a study of the lipid composition of the erythrocyte membrane, including the main fractions of phospholipids and free cholesterol, as well as the level of intracellular Ca2+ and lipid peroxidation products - malondialdehyde and diene conjugates. Microcirculation was assessed using the method of conjunctival biomicroscopy. RESULTS: One month after the course of LT, patients showed a significant increase in exercise tolerance by 37.8%, a decrease in systolic blood pressure with a standard load by 9.9%. The improvement of the clinical picture occurred against the background of a decrease in the activity of lipid peroxidation and structural changes in the cell membrane: an increase in polyunsaturated fractions of phospholipids and a decrease in the cholesterol content, as well as a decrease in the Ca2+ level in the cell from 0.23 [0.19; 0.32] to 0.20 [0.16; 0.26] mmol/l. The results of the analysis of conjunctival biomicroscopy demonstrated a statistically significant decrease in the ratio of arteriolovenular calibers, a limitation of the severity of sludge syndrome by 59%, and an almost twofold (from 3.9±0.52 to 7.2±1.23 cap/mm2) increase in capillary density. CONCLUSION: The data obtained showed that in patients with hypertension in combination with coronary artery disease, LT causes positive changes in the lipid structure of the cell membrane and microcirculation parameters, which is accompanied by a hypotensive effect and an improvement in the clinical and functional state of patients.


Assuntos
Doença da Artéria Coronariana , Hipertensão , Terapia a Laser , Adulto , Colesterol/análise , Colesterol/metabolismo , Doença da Artéria Coronariana/complicações , Doença da Artéria Coronariana/metabolismo , Membrana Eritrocítica/química , Membrana Eritrocítica/metabolismo , Membrana Eritrocítica/efeitos da radiação , Feminino , Humanos , Hipertensão/complicações , Hipertensão/radioterapia , Masculino , Microcirculação , Pessoa de Meia-Idade , Fosfolipídeos/análise , Fosfolipídeos/metabolismo
10.
BMJ Case Rep ; 15(4)2022 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-35396242

RESUMO

To describe a case of acute-onset neovascular glaucoma (NVG) after a neodymium:yttrium-aluminium-garnet (Nd:YAG) capsulotomy in a diabetic vitrectomized eye of a patient with severe systemic and ocular comorbidities. A man in his 50s underwent a Nd:YAG capsulotomy for visually significant posterior capsular opacification with a previous history of vitrectomy with silicone oil in situ for diabetic retinopathy. He had systemic and ocular comorbidities implicating an advanced ischaemic status, both systemically and locally. Five days post Nd:YAG capsulotomy, extensive neovascularisation of the iris and angles was noted. Despite maximum antiglaucoma medication, an evisceration ensued due to intractable NVG. This case report highlights the importance of irreversible complications after a seemingly simple capsulotomy in eyes with advanced ocular conditions and systemic comorbidities necessitating extreme caution.


Assuntos
Opacificação da Cápsula , Diabetes Mellitus , Retinopatia Diabética , Glaucoma Neovascular , Terapia a Laser , Lasers de Estado Sólido , Opacificação da Cápsula/cirurgia , Retinopatia Diabética/cirurgia , Glaucoma Neovascular/etiologia , Glaucoma Neovascular/cirurgia , Humanos , Terapia a Laser/efeitos adversos , Lasers de Estado Sólido/efeitos adversos , Masculino , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/cirurgia
11.
Sci Rep ; 12(1): 6928, 2022 Apr 28.
Artigo em Inglês | MEDLINE | ID: mdl-35484183

RESUMO

In this work we present a facile method for the fabrication of several capacitive transduction electrodes for sensing applications. To prepare the electrodes, line widths up to 300 [Formula: see text]m were produced on polymethyl methacrylate (PMMA) substrate using a common workshop laser engraving machine. The geometries prepared with the laser ablation process were characterised by optical microscopy for consistency and accuracy. Later, the geometries were coated with functional polymer porous cellulose decorated sensing layer for humidity sensing. The resulting sensors were tested at various relative humidity (RH) levels. In general, good sensing response was produced by the sensors with sensitivities ranging from 0.13 to 2.37 pF/%RH. In ambient conditions the response time of 10 s was noticed for all the fabricated sensors. Moreover, experimental results show that the sensitivity of the fabricated sensors depends highly on the geometry and by changing the electrode geometry sensitivity increases up to 5 times can be achieved with the same sensing layer. The simplicity of the fabrication process and higher sensitivity resulting from the electrode designs is expected to enable the application of the proposed electrodes not only in air quality sensors but also in many other areas such as touch or tactile sensors.


Assuntos
Terapia a Laser , Lasers , Eletrodos , Umidade
12.
HNO ; 70(5): 371-379, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35419634

RESUMO

Human papillomavirus (HPV)-associated squamous cell carcinoma of the oropharynx is a malignancy of increasing prevalence. The oncologic community is currently evaluating the safety and efficacy of de-intensifying treatment without compromising oncologic outcomes. Paramount to these treatment algorithms is primary surgery through transoral approaches. This article reviews the literature and concepts pertaining to transoral surgery and describes the two most common techniques, transoral laser microsurgery (TLM) and transoral robotic surgery (TORS).


Assuntos
Carcinoma de Células Escamosas , Terapia a Laser , Neoplasias Orofaríngeas , Procedimentos Cirúrgicos Robóticos , Humanos , Terapia a Laser/métodos , Microcirurgia/métodos , Neoplasias Orofaríngeas/diagnóstico , Neoplasias Orofaríngeas/patologia , Neoplasias Orofaríngeas/cirurgia , Procedimentos Cirúrgicos Robóticos/métodos , Resultado do Tratamento
13.
Gen Dent ; 70(3): 56-59, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35467545

RESUMO

The use of high-power diode laser technology follows the principles of minimally invasive dentistry. Laser technology is used frequently in pediatric dentistry, especially in surgical procedures, because this approach favors hemostasis, eliminates the use of sutures, improves healing, minimizes treatment time, reduces the sensation of pressure and vibration experienced by the patient, and creates more comfortable postoperative conditions. This article describes the use of high-power diode lasers to perform 3 minor oral surgical procedures--biopsy, lingual frenectomy, and operculectomy--in 2 children. In all 3 treatments, the operative time did not exceed 5 minutes, no sutures were used, and no postoperative complications were reported. Thus, high-power diode lasers can be considered an alternative approach to minor oral surgery that decreases chair time, reduces postoperative complications, and minimizes stress and anxiety in pediatric patients.


Assuntos
Terapia a Laser , Procedimentos Cirúrgicos Bucais , Criança , Humanos , Lasers Semicondutores/uso terapêutico , Freio Lingual/cirurgia , Cicatrização
14.
J Agric Food Chem ; 70(16): 5237-5244, 2022 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-35438492

RESUMO

Food fraud is a growing problem, especially misdeclaration due to regional price differences offering a wide field. Fast, powerful, and cost-effective analytical methods are therefore essential to counteract food fraud. The isotopolome is suitable for origin discrimination and was analyzed in this study using laser ablation inductively coupled plasma mass spectrometry (ICP-MS). A total of 250 almond samples from six countries and four crop years were analyzed and evaluated by chemometric methods. By using a ratio-based assessment, calibration problems were avoided and an origin predictive accuracy of 85.2 ± 1.2% was achieved. Compared to ICP-MS with solution nebulization, the analysis time could be reduced to about one-fifth.


Assuntos
Terapia a Laser , Prunus dulcis , Espectrometria de Massas/métodos , Prunus dulcis/química , Análise Espectral
15.
Sci Rep ; 12(1): 6959, 2022 Apr 28.
Artigo em Inglês | MEDLINE | ID: mdl-35484198

RESUMO

Femtosecond laser-assisted keratoplasty has been proposed as a treatment option for corneal transplantation. In this study, we investigated and compared the outcomes of Ziemer Z8 femtosecond laser (FSL)-assisted penetrating keratoplasty (PK) using a liquid interface versus flat interface. Thirty fresh porcine eyes underwent FSL-assisted PK with the Z8 using different levels of energies (30%, 90% or 150%) and different interfaces (liquid or flat). The real-time intraocular pressure (IOP) changes, incision geometry, corneal endothelial damage, as well as the accuracy of laser cutting and tissue reaction, were performed and compared. We found that the overall average IOP at all laser trephination stages was significantly higher with the flat interface, regardless of the energy used (68.9 ± 15.0 mmHg versus 46.1 ± 16.6 mmHg; P < 0.001). The overall mean laser-cut angle was 86.2º ± 6.5º and 88.2º ± 1.0º, for the liquid and flat platform respectively, indicating minimal deviation from the programmed angle of 90º. When high energy (150%) was used, the endothelial denuded area was significantly greater with the flat interface than with liquid interface (386.1 ± 53.6 mm2 versus 139.0 ± 10.4 mm2 P = 0.02). The FSL cutting did not cause obvious tissue reaction alongside the laser cut on histological evaluation. The results indicated a liquid interface is the preferable choice in FSL-assisted corneal transplantation.


Assuntos
Lesões da Córnea , Transplante de Córnea , Terapia a Laser , Animais , Transplante de Córnea/métodos , Ceratoplastia Penetrante/métodos , Terapia a Laser/métodos , Lasers , Suínos , Tonometria Ocular
16.
Rev. Odontol. Araçatuba (Online) ; 43(1): 41-44, jan.-abr. 2022. ilus
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1361662

RESUMO

Background: Glanzmann thrombasthenia (GT) is a rare autosomal recessive disorder characterized by platelet function impairment. Considering that the oral cavity is highly vascularized and performing some local hemostatic maneuvers may be difficult, GT patients are at high risk for hemorrhage related to invasive oral procedures. This study aimed to present an alternative method for periodontal surgery in a young GT patient. Case Report: A 15-year-old female GT patient with a recent history of excessive bleeding following dental surgeries was referred to a public dental center, presenting gingival hyperplasia. The procedure was performed using a high-power laser (HPL), and except for local anesthesia with epinephrine, no further hemostatic agent was necessary. Conclusion: According to the case, the HPL seems to be an efficient tool for preventing perioperative bleeding in GT patients submitted to minor oral surgeries(AU)


Introdução: A trombastenia de Glanzmann (TG) é uma doença autossômica recessiva rara caracterizada por comprometimento da função plaquetária. Tendo em vista que a cavidade oral é altamente vascularizada e a realização de algumas manobras hemostáticas locais pode ser difícil, pacientes com TG apresentam alto risco de hemorragia relacionada a procedimentos orais invasivos. Este artigo teve como objetivo apresentar uma técnica alternativa para cirurgia periodontal em um paciente jovem com TG. Relato de Caso: Paciente com TG, sexo feminino, 15 anos, com história recente de sangramento excessivo relacionado a cirurgias odontológicas prévias, foi encaminhada a um centro odontológico público apresentando hiperplasia gengival. O procedimento de remoção foi realizado com laser de alta potência e, com exceção da anestesia local com epinefrina, nenhum outro agente hemostático foi necessário. Conclusão: De acordo com o caso, o laser de alta potência parece ser uma ferramenta eficiente na prevenção de sangramento perioperatório em pacientes com TG submetidos a pequenas cirurgias orais(AU)


Assuntos
Humanos , Feminino , Adolescente , Cirurgia Bucal , Trombastenia , Transtornos da Coagulação Sanguínea , Terapia a Laser , Lasers Semicondutores , Hiperplasia Gengival
17.
Sci Rep ; 12(1): 5837, 2022 Apr 07.
Artigo em Inglês | MEDLINE | ID: mdl-35393487

RESUMO

Laser-based material removal, or ablation, using ultrafast pulses enables precision micro-scale processing of almost any material for a wide range of applications and is likely to play a pivotal role in providing mass customization capabilities in future manufacturing. However, optimization of the processing parameters can currently take several weeks because of the absence of an appropriate simulator. The difficulties in realizing such a simulator lie in the multi-scale nature of the relevant processes and the high nonlinearity and irreversibility of these processes, which can differ substantially depending on the target material. Here we show that an ultrafast laser ablation simulator can be realized using deep neural networks. The simulator can calculate the three-dimensional structure after irradiation by multiple laser pulses at arbitrary positions and with arbitrary pulse energies, and we applied the simulator to a variety of materials, including dielectrics, semiconductors, and an organic polymer. The simulator successfully predicted their depth profiles after irradiation by a number of pulses, even though the neural networks were trained using single-shot datasets. Our results indicate that deep neural networks trained with single-shot experiments are able to address physics with irreversibility and chaoticity that cannot be accessed using conventional repetitive experiments.


Assuntos
Terapia a Laser , Terapia a Laser/métodos , Lasers , Luz , Redes Neurais de Computação , Semicondutores
18.
Dermatol Clin ; 40(2): 215-225, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35366974

RESUMO

Laser therapy is an effective treatment that can be used in a wide range of cutaneous conditions in pediatric dermatology. It is an important tool to have in one's armamentarium. The parameters within each laser can vary greatly by the make and model of the laser, making it difficult to make settings generalizable. The goal of this article is to provide some general guiding principles for laser choice, theory behind laser parameter choice, and education surrounding tissue response which will guide treatment parameter changes.


Assuntos
Dermatologia , Terapia a Laser , Terapia com Luz de Baixa Intensidade , Dermatopatias , Criança , Humanos , Dermatopatias/cirurgia
19.
J Agric Food Chem ; 70(15): 4765-4773, 2022 Apr 20.
Artigo em Inglês | MEDLINE | ID: mdl-35385276

RESUMO

Quantification of trace and minor nutrient elements is crucial for maintaining human health. A reliable laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) method for food materials was developed by combining fine food powder (dm < 3 µm) pellets as the external standard with an average C content as the internal standard (IS). The finer and homogeneous aerosol produced by ablating the fine powder pellets is beneficial for transportation and analyte ionization in ICP, which helps alleviate the matrix effects and improves the analytical precision and accuracy. The average C content is 39.9 ± 1.9% for plant-derived foods (n = 22) and 46.9 ± 1.1% for animal-derived foods (n = 7). The accuracy (recovery, 80-120%) and precision (RSD, 0.5-9.8%) were validated by analyzing a series of food certified reference materials. The high-throughput method is a promising alternative for routine sample analysis in food safety laboratories.


Assuntos
Terapia a Laser , Lasers , Animais , Espectrometria de Massas/métodos , Pós , Análise Espectral
20.
Can J Urol ; 29(2): 11067-11074, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35429424

RESUMO

INTRODUCTION: Holmium laser enucleation of the prostate (HoLEP) is an effective but underutilized option for the surgical management of benign prostatic hyperplasia (BPH). With low adoption, questions arise surrounding patients access to care. It is unclear whether patients undergoing HoLEP are local or specifically seek care from afar. We looked to determine the proportion of patients who traveled out-of-state for HoLEP treatment and the impact of travel on peri and postoperative metrics. MATERIALS AND METHODS: We performed a retrospective cohort study evaluating patients that underwent HoLEP at a single institution from 2007-2019. Patient demographic, perioperative data, postoperative outcomes, travel distance and income data were compared between those who traveled and did not travel out-of-state for care. RESULTS: From 2007-2019, 1565 patients underwent HoLEP at our institution. The mean age was 70.0 years, average body mass index (BMI) of 27.9 kg/m2, and 91.6% identified as Caucasian; 44.2% of patients traveled from out-of-state for HoLEP care, traveling a median of 597 miles. Patients who came from out-of-state had larger prostates (p = 0.005) and worse preoperative International Prostate Symptom Score (IPSS) total and bother scores (p = 0.002). There was no difference in immediate, 30 or 90 day complications rates. In- and out-of-state patients had similar postoperative urinary and functional outcomes. CONCLUSIONS: A large proportion of patients specifically seek out HoLEP and travel out-of-state for care. The reasons are likely multifactorial -including advanced disease, lack of local care and healthcare consumerism. These results have implications both for those currently providing HoLEP as a treatment option as well as those motivated to start a HoLEP practice.


Assuntos
Terapia a Laser , Lasers de Estado Sólido , Hiperplasia Prostática , Ressecção Transuretral da Próstata , Idoso , Hólmio , Humanos , Terapia a Laser/métodos , Lasers de Estado Sólido/uso terapêutico , Masculino , Hiperplasia Prostática/complicações , Hiperplasia Prostática/cirurgia , Estudos Retrospectivos , Ressecção Transuretral da Próstata/métodos , Resultado do Tratamento
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