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1.
Zhonghua Yan Ke Za Zhi ; 57(3): 228-231, 2021 Mar 11.
Artigo em Chinês | MEDLINE | ID: mdl-33721963

RESUMO

The study aimed to introduce a new analysis method of 24-hour intraocular pressure (IOP) and to propose the concept of overall IOP. Data of 24-hour IOP of a patient with a confirmed diagnosis of normal tension glaucoma was selected. Based on the present indexes including peak IOP, trough IOP, maximum difference, and mean IOP, new indexes were proposed, which included main IOP, duration of main IOP, and rate of IOP increase. A radar chart was drawn, and overall IOP was calculated. Overall IOP value = IOP distribution (sum of IOP value multiplied by the corresponding duration) × IOP fluctuation (standard deviation) × rate of IOP increase/100. By comparing two series of IOP data, the advantages of the new IOP indexes were demonstrated. The introduction of the concept of overall IOP expands the description of IOP from a single static state to a comprehensive dynamic state, which enables us to analyze the results of 24-hour IOP monitoring more thoroughly. (Chin J Ophthalmol, 2021, 57: 228-231).


Assuntos
Glaucoma de Ângulo Aberto , Glaucoma de Baixa Tensão , Ritmo Circadiano , Humanos , Pressão Intraocular , Tonometria Ocular
2.
Cesk Slov Oftalmol ; 77(1): 18-21, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33740863

RESUMO

AIM: To compare parameters of phacoemulsification using handpiece Active Sentry and Centurion Ozil. METHODS: We have evaluated results of 200 eyes of 129 patients that were operated for cataract at the Department of Ophthalmology. All surgeries were performed by one surgeon (NJ). In 100 eyes handpiece Active Sentry was used and in 100 eyes handpiece Centurion Ozil was used. The intraocular pressure during surgery (IOP), cumulative dissipated energy (CDE), ultrasound time (U/S time) and estimated consumption of balanced salt solution (BSS) were evaluated. RESULTS: Using handpiece Ozil Centurion the IOP was 65 mmHg, use handpiece Active Sentry enabled decrease safely peroperative IOP to 46 mm Hg withouth increase of fluctuation or declension of stability of the anterior chamber. The mean CDE a U/S time were significantly statistically decreased using Active Sentry versus Centurion Ozil handpieces. Difference in estimated consumption of balanced salt solution was not statistically significant. CONCLUSION: Our results proved that using handpiece Active Sentry enabled statistically significantly decrease IOP during phacoemulsification and eliminated post-occlusion surge. This brings several advantages: more painless surgery for patients and more user-friendly procedure for surgeon especially in challenging cases (intraoperative floppy iris syndrome or severe myopia).


Assuntos
Catarata , Facoemulsificação , Câmara Anterior , Humanos , Pressão Intraocular , Tonometria Ocular
3.
Klin Monbl Augenheilkd ; 238(2): 132-145, 2021 Feb.
Artigo em Inglês, Alemão | MEDLINE | ID: mdl-33578436

RESUMO

The prognosis of going blind is very stressful for patients diagnosed with "glaucoma". Worries and fear of losing independence is a constant mental burden, with secondary risks of depression and social isolation. But stress is not only a result of glaucoma but also a possible cause (risk factor). This should not be surprising, given that chronic stress can trigger "psychosomatic" organ dysfunctions anywhere in the body. Why should the organ "eye" be an exception? Indeed, glaucoma patients often suspect that severe emotional stress caused their visual field loss or "foggy vision". The hypothesis that stress is a possible cause of glaucoma is supported by different observations: (i) acute and chronic stress increases intraocular pressure and (ii) long-term stress can lead to vascular dysregulation of the microcirculation in the eye and brain ("Flammer's syndrome"), leading to partial hypoxia and hypoglycaemia (hypo-metabolism). Even if nerve cells do not die, they may then become inactive ("silent" neurons). (iii) Degenerative changes have been reported in the brain of glaucoma patients, affecting not only anterograde or transsynaptic areas of the central visual pathway, but degeneration is also found (iv) in brain areas involved in emotional appraisal and the physiological regulation of stress hormones. There are also psychological hints indicating that stress is a cause of glaucoma: (v) Glaucoma patients with Flammer's syndrome show typical personality traits that are associated with low stress resilience: they often have cold hands or feet, are ambitious (professionally successful), perfectionistic, obsessive, brooding and worrying a lot. (vi) If stress hormone levels and inflammation parameters are reduced in glaucoma patients by relaxation with meditation, this correlates with normalisation of intraocular pressure, and yet another clue is that (vii) visual field improvements after non-invasive current stimulation therapy, that are known to improve circulation and neuronal synchronisation, are much most effective in patients with stress resilient personalities. An appreciation of stress as a "cause" of glaucoma suggests that in addition to standard therapy (i) stress reduction through relaxation techniques should be recommended (e.g. meditation), and (ii) self-medication compliance should not be induced by kindling anxiety and worries with negative communication ("You will go blind!"), but communication should be positive ("The prognosis is optimistic").


Assuntos
Glaucoma , Humanos , Pressão Intraocular , Tonometria Ocular , Testes de Campo Visual , Vias Visuais
4.
Sensors (Basel) ; 21(2)2021 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-33467457

RESUMO

Glaucoma causes total or partial loss of vision in 10% of people over the age of 70, increasing their fragility and isolation. It is characterised by the destruction of the optic nerve fibres, which may result from excessively high intraocular pressure as well as other phenomena. Diagnosis is currently reached through a combination of several checks, mainly of the eyes' fundus, tonometry and gonioscopy. Prior to validation for human subjects, the objective of this study is to validate whether ocular phantom-based models could be used to diagnose glaucoma using an onboard system, which could, even at home, prevent the early-stage development of the pathology. Eight phantoms modelling healthy eyes and eight phantoms modelling eyes with glaucoma due to excessive intraocular pressure were measured using an onboard system, including lens and electrophysiology electronics. We measured the actual average Zr (real part of impedance) impedance of 160.9 ± 24.3 ohms (glaucoma ocular phantom models) versus 211.9 ± 36.9 ohms (healthy ocular phantom models), and an average total water volume (Vt) of 3.02 ± 0.35 mL (glaucoma ocular phantom models) versus 2.45 ± 0.28 mL (healthy ocular Phantoms). On average, we obtained 51 ohms (-24.1%) less and 0.57 mL (22.9%) of total water volume more, respectively. Normality tests (Shapiro-Wilk) for Vt and Zr indicate p < 0.001 and p < 0.01, respectively. Since these variables do not respect normal laws, unmatched Mann-Whitney tests were performed indicating a significant difference between Vt and Zr in the healthy ocular phantom models and those modelling glaucoma. To conclude, this preliminary study indicates the possibility of discriminating between healthy eyes with those with glaucoma. However, further large-scale studies involving healthy eyes and those suffering from glaucoma are necessary to generate viable models.


Assuntos
Glaucoma , Hipertensão Ocular , Diagnóstico Precoce , Estudos de Viabilidade , Glaucoma/diagnóstico , Humanos , Modelos Teóricos , Tonometria Ocular
5.
J Zoo Wildl Med ; 51(4): 1012-1016, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33480583

RESUMO

Reference intervals of intraocular pressure (IOP) are poorly described in piscine species as the factors that may influence it. Rebound tonometry was used to measure IOP in 28 adult brook trout (Salvelinus fontinalis) anesthetized in a buffered solution of 60 mg/L tricaine methanesulfonate (n = 16) or restrained with electronarcosis (n = 12) at 16 mA. There was no significant effect of the eye side, sex, fish origin, and body weight, but IOP values were significantly higher with electronarcosis (mean ± SD: 16.4 ± 5.0 mm Hg) than with immersion anesthesia (10.8 ± 3.3 mm Hg; P = 0.0017). The same restraint method should be used for comparison with previously published IOP values or when evaluating individual variations over time.


Assuntos
Aminobenzoatos/farmacologia , Eletronarcose/veterinária , Pressão Intraocular/fisiologia , Tonometria Ocular/veterinária , Truta/fisiologia , Anestésicos/farmacologia , Animais , Feminino , Pressão Intraocular/efeitos dos fármacos , Masculino , Tonometria Ocular/métodos
6.
J Zoo Wildl Med ; 51(4): 879-888, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33480568

RESUMO

Ophthalmic studies of the Texas tortoise (Gopherus berlandieri) established normal ophthalmic parameters for select diagnostic tests in captive tortoises and assessment of differences among individuals of differing size and health status. Sixty-one tortoises of varying weight, shell size, Mycoplasma seroprevalence, and herpesvirus exposure were included. Complete ophthalmic examinations, including neuro-ophthalmic reflexes, phenol red thread test, rebound tonometry, fluorescein staining, palpebral fissure length measurement, slit lamp biomicroscopy, indirect fundoscopy, and ocular ultrasound measurements of axial globe length, anterior chamber depth, lens thickness, and vitreous length, were recorded. All tortoises had negative dazzle and pupillary light reflexes, inconsistent menace responses, and positive palpebral reflexes. Mean ± SD tear production and intraocular pressure (IOP) were 14.2 ± 5.6 mm/15 sec and 13.8 ± 2.4 mm Hg in healthy tortoises, respectively. Mycoplasma-seropositive tortoises (with or without herpesvirus exposure) had significantly increased tear production (20.2 ± 8.1 and 19.9 ± 8.9 mm/15 sec, respectively) compared with healthy seronegative tortoises (14.2 ± 5.6 mm/15 sec; P = 0.02). As body size decreased, so too did palpebral fissure length and ocular ultrasound measurements, while IOP increased. Overall, palpebral fissure length appeared relatively small, and tear production relatively increased compared with other chelonian species, likely on the basis of the relatively arid native habitat. Further work is recommended to establish baseline values in related species, as well as comparison in aquatic versus terrestrial chelonians. The authors further suggest that the finding of relatively increased tear production in tortoises may indicate the need to rule out mycoplasmosis as a cause of upper respiratory tract disease.


Assuntos
Olho/anatomia & histologia , Tartarugas/anatomia & histologia , Animais , Oftalmopatias/patologia , Feminino , Masculino , Mycoplasma/isolamento & purificação , Lágrimas , Tonometria Ocular
7.
Nan Fang Yi Ke Da Xue Xue Bao ; 41(1): 107-110, 2021 Jan 30.
Artigo em Chinês | MEDLINE | ID: mdl-33509761

RESUMO

OBJECTIVE: To investigate accuracy of the currently used strategies for intraocular pressure measurements for reflecting actual 24-hour intraocular pressure fluctuations. METHODS: From September, 2018 to January, 2019, the patients with a suspected diagnosis of primary open angle glaucoma at our hospital were prospectively enrolled to receive 24-hour intraocular pressure monitoring using a Goldmann tonometer. With the intraocular pressure measurements at 0:00, 2:00, 5:00, 7:00, 8:00, 10:00, 11:00, 14:00, 16:00, 18:00, 20:00, and 22:00 as the gold standard (strategy 1), we compared the measurements taken at 5:00, 7:00, 10:00, 14:00, 18:00, and 22:00 (strategy 2) and at 8:00, 11:00, 14:00, and 16:00 (strategy 3) for their accuracy in reflecting 24-h intraocular pressure fluctuations. RESULTS: A total of 41 patients (82 eyes) were enrolled in this study. The peak intraocular pressures measured using the 3 strategies were 21.09±4.15 mmHg, 20.54±4.10 mmHg, and 19.91±4.38 mmHg, respectively, showing significant differences among them (P < 0.05). The trough intraocular pressures measured by the 3 strategies were also significantly different (13.93±3.38 mmHg, 14.63±3.49 mmHg, and 15.46±3.63 mmHg, respectively; P < 0.05). The co-occurrence of the peak intraocular pressure was 74.39% between strategies 1 and 2 and 43.90% between strategies 1 and 3. The sensitivity of strategies 2 and 3 for detecting 24-h intraocular pressure fluctuations was 55.56% and 36.11%, respectively. CONCLUSIONS: For suspected cases of glaucoma, intraocular pressure measurements at 4 and 6 time points of a day can not precisely reflect the actual range of intraocular pressure fluctuations, and may lead to a missed diagnosis of glaucoma.


Assuntos
Glaucoma de Ângulo Aberto , Glaucoma , Glaucoma/diagnóstico , Humanos , Pressão Intraocular , Estudos Prospectivos , Tonometria Ocular
8.
Am J Vet Res ; 82(2): 138-143, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33480276

RESUMO

OBJECTIVE: To investigate the effects of orally administered trazodone on intraocular pressure (IOP), pupil diameter measured in the vertical plane (ie, vertical pupil diameter [VPD]), selected physical examination variables, and sedation level in healthy equids. ANIMALS: 7 horses and 1 pony. PROCEDURES: Food was withheld for 12 hours prior to drug administration. After baseline (time 0) sedation scoring, physical examination, and measurement of IOP and VPD, equids received 1 dose (approx 6 mg/kg) of trazodone orally. Examination and measurement procedures were repeated 0.5, 1, 2, 4, 8, 12, and 24 hours after drug administration. Blood samples were collected at each time point for analysis of plasma trazodone concentrations. Repeated-measures analysis was used to compare examination results between downstream time points and baseline. RESULTS: 7 of 8 equids had mild sedation from 0.5 to 8 hours after treatment; compared with baseline values, mean IOP was significantly lower from 0.5 hours to 8 hours, mean VPD was significantly smaller at 0.5 hours, and mean rectal temperature was significantly lower from 1 to 8 hours after drug administration. Adverse effects (signs of excitement in 1 equid and sweating in 4) were self-limiting and considered minor. Mean maximum plasma concentration of trazodone was 1,493 ng/mL 0.75 hours after administration, and terminal half-life of the drug was 9.96 hours. CONCLUSIONS AND CLINICAL RELEVANCE: The described oral dose of trazadone elicited sedation with a few self-limiting adverse effects in the study sample. Drug effects on IOP and VPD may alter ocular examination findings. Further investigation is warranted prior to use of trazodone for sedation in equids, particularly those with ophthalmic conditions.


Assuntos
Trazodona , Animais , Cavalos , Pressão Intraocular , Exame Físico , Pupila , Tonometria Ocular , Trazodona/farmacologia
9.
Curr Opin Ophthalmol ; 32(2): 83-91, 2021 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-33470671

RESUMO

PURPOSE OF REVIEW: The study was undertaken to assess the current importance of clinical examination of the optic nerve head (ONH) in glaucoma management. RECENT FINDINGS: ONH changes in glaucoma are easily assessed with good specificity on examination, whereas imaging has not been able to identify pallor of the neuroretinal rim (NRR), disc hemorrhages, or vascular signs of acquired cupping. Glaucomatous neuropathy in primary open angle glaucoma (POAG) has extensive databases on imaging machines, however, other glaucomas such as primary angle closure glaucoma (PACG), juvenile open angle glaucoma (JOAG), congenital, and secondary glaucomas have been reported to have a significantly different ONH morphology. Clinical evaluation with knowledge of the underlying cause of glaucoma allows easy diagnosis of any abnormality, whereas the absence of an imaging database in such eyes makes diagnosis difficult on optical coherence tomography (OCT) and so forth. In eyes with congenital anomalies and dysplastic discs, clinical examination and history provide better identification of glaucomatous damage. Staging of glaucoma on ONH examination when perimetry is unreliable provides a means of determining the amount of damage and appropriate reduction of intraocular pressure (IOP). SUMMARY: Clinical examination of the ONH is very relevant for screening, diagnosis, staging, and management of all glaucomas, and is irreplaceable in detecting nonglaucomatous causes of ONH cupping and visual field defects similar to those in glaucoma.


Assuntos
Glaucoma/diagnóstico , Disco Óptico/patologia , Doenças do Nervo Óptico/diagnóstico , Exame Físico , Humanos , Pressão Intraocular , Tonometria Ocular , Transtornos da Visão/diagnóstico , Transtornos da Visão/fisiopatologia , Testes de Campo Visual/métodos , Campos Visuais/fisiologia
10.
Curr Opin Ophthalmol ; 32(2): 160-168, 2021 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-33315726

RESUMO

PURPOSE OF REVIEW: This article reviews the safety profile of trabecular meshwork/Schlemm's canal-based, subconjunctival, and suprachoroidal minimally invasive glaucoma surgery (MIGS). RECENT FINDINGS: Prospective randomized clinical trials and metaanalyses published during the 2019-2020 review period provided important data regarding the safety profile of trabecular meshwork/Schlemm's canal-based MIGS. Transient hyphema and intraocular pressure spikes are among the most common complications associated with this category of MIGS, but more serious adverse events such as cyclodialysis cleft formation may also occur. Trabecular bypass microstents and the intracanalicular scaffold are further subject to device-related complications, including malposition and obstruction. Recent case reports and retrospective case series have further characterized the safety profile of the subconjunctival gel stent, with adverse events ranging from self-limited hypotony to visually devastating endophthalmitis and suprachoroidal hemorrhage. Five-year results of the COMPASS XT study demonstrated significantly greater endothelial cell loss in patients randomized to receive CyPass Micro-Stent (Alcon Laboratories, Fort Worth, TX, USA) in combination with cataract surgery versus those who underwent cataract surgery alone, and ultimately led to a Food and Drug Administration Class I recall of the device. SUMMARY: Trabecular meshwork/Schlemm's canal-based procedures are generally among the safest MIGS, with mostly self-limited and nonvision-threatening complications. Subconjunctival gel stent insertion is associated with both bleb-related and stent-specific adverse events, which are similar to those observed with trabeculectomy and tube shunt surgery, respectively. Removal of the CyPass Micro-Stent from the market underscores the need for high-quality, long-term safety data regarding MIGS.


Assuntos
Implantes para Drenagem de Glaucoma/efeitos adversos , Glaucoma de Ângulo Aberto/cirurgia , Procedimentos Cirúrgicos Minimamente Invasivos/efeitos adversos , Malha Trabecular/cirurgia , Trabeculectomia/efeitos adversos , Glaucoma de Ângulo Aberto/fisiopatologia , Humanos , Pressão Intraocular/fisiologia , Tonometria Ocular
12.
Zhonghua Yi Xue Za Zhi ; 100(48): 3841-3845, 2020 Dec 29.
Artigo em Chinês | MEDLINE | ID: mdl-33371628

RESUMO

Objective: To explore the prevalence and risk factors of common blinding ocular diseases in the population aged 30 years and above in rural areas of Handan City from 2006 to 2012. Methods: A cohort study with 6 830 subjects from rural areas of Handan City, Hebei Province was designed and conducted. The follow-up duration was 6 years, and the prevalence and incidence of common blinding diseases were evaluated. Logistic regression was used to explore the influencing factors of common blinding ocular diseases. Results: In 2006, 6 830 people participated in the baseline survey. There were 3 163 (46.31%) males and 3 667 (53.69%) females. The average age was (52.3±12.2) years (range, 30 to 97 years). There were 3 435 subjects who had common chronic systematic diseases, with a prevalence of 50.29%. In addition, 1 250 people suffered from common blinding ocular diseases, and the prevalence was 18.30%. There were 4 118 subjects without common blinding ocular diseases at baseline who participated in the six-year follow-up, during the 6-year follow-up, 247 participants developed common blinding ocular diseases. 9% (171/1 899) of patients with chronic systematic diseases developed common blinding ocular diseases, while only 3.42% (76/2 219) of normal subjects developed common blinding ocular diseases, with a statistically significant difference (χ(2)=56.504, P<0.001). The incidence of common blinding ocular diseases was age-dependent. Multivariate regression analysis showed that age (OR=1.045, 95%CI: 1.028-1.062, P<0.001), intraoccular pressure (IOP) (OR=1.064, 95% CI: 1.014-1.116, P=0.011) and baseline chronic diseases (OR=1.749, 95% CI: 1.288-2.375, P<0.001) were risk factors for common blinding ocular diseases. Moreover, the contribution of age, IOP and chronic systematic diseases to the model was 0.436, 0.084 and 0.511, respectively. Conclusions: The prevalence of common blinding ocular diseases among people over 30 years old in Handan is relatively high. From 2006 to 2012, about 1.5% patients of chronic systematic diseases developed common blinding ocular diseases each year. Moreover, chronic systematic diseases increase the risk of blinding ocular diseases sharply, and the effect is stronger than age and intraocular pressure.


Assuntos
População Rural , Tonometria Ocular , Adulto , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco
13.
BMC Ophthalmol ; 20(1): 490, 2020 Dec 17.
Artigo em Inglês | MEDLINE | ID: mdl-33334311

RESUMO

BACKGROUND: The aim of this retrospective study was to compare the efficacy and safety profile of a single XEN-microstent in different types of primary and secondary open angle glaucoma. METHODS: A single XEN microstent was implanted in patients with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), pseudoexfoliation glaucoma (PEX) and secondary glaucoma (Sec.Gl). The intraocular pressure (IOP), the active substances of the applied IOP-lowering drugs, the best corrected visual acuity (BCVA) and the mean deviation (MD) of the perimetry were measured at baseline and at regular follow-ups, scheduled at 2 days and 1, 3, 6 and 12 months after surgery. RESULTS: 153 eyes were included in this analysis. 113 eyes were affected by POAG (74%), 5 eyes by NTG (3%), 22 eyes by PEX (14%) and 13 eyes by Sec. Gl (9%). Mean IOP decreased in all treatment groups during the 12 months of follow-up (complete group: 23.9 ± 7.4 to 15.4 ± 5.1 mmHg (p < 0.01); POAG: 22.8 ± 6.5 to 15.1 ± 4.6 mmHg (p < 0.01); NTG: 16.6 ± 3.4 to 11.6 ± 2.2 mmHg (p < 0.05); PEX: 28.0 ± 7.9 to 17.1 ± 6.6 mmHg (p < 0.01); Sec.Gl: 28.9 ± 13.9 to 15.5 ± 6.9 mmHg (p < 0.05)). In the 153 eyes the average number of IOP-lowering drugs applied decreased from 2.6 ± 1.2 to 0.8 ± 1.3 12 months after surgery (p < 0.01). BCVA and mean deviation of automated standard perimetry remained stable in all groups during follow-up. CONCLUSION: As in eyes suffering from POAG, IOP and number of IOP-lowering drugs applied can be effectively reduced by XEN implantation in eyes suffering from NTG, PEX and secondary glaucoma while leaving BCVA and visual field unchanged. TRIAL REGISTRATION: Trial was registered at DRKS (registration number: DRKS00020800 , Registered 25.February 2020 - Retrospectively registered).


Assuntos
Implantes para Drenagem de Glaucoma , Glaucoma de Ângulo Aberto/cirurgia , Stents , Idoso , Idoso de 80 Anos ou mais , Anti-Hipertensivos/administração & dosagem , Feminino , Seguimentos , Glaucoma de Ângulo Aberto/fisiopatologia , Humanos , Pressão Intraocular/efeitos dos fármacos , Pressão Intraocular/fisiologia , Masculino , Pessoa de Meia-Idade , Implantação de Prótese , Estudos Retrospectivos , Tonometria Ocular , Resultado do Tratamento , Acuidade Visual/fisiologia , Testes de Campo Visual , Campos Visuais/fisiologia
14.
Am J Vet Res ; 81(12): 973-984, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33251843

RESUMO

OBJECTIVE: To determine the effects of gabapentin, tramadol, and meloxicam on tear production, intraocular pressure (IOP), pupillary diameter, tear break-up time, and corneal touch threshold in healthy dogs when given orally for 3 days. ANIMALS: 9 healthy research Beagles. PROCEDURES: A randomized, blinded, case-crossover study with a 6-sequence, 3-treatment, and 3-period design was performed. A 7-day acclimation period was followed by 3 treatment phases, each with a 3-day treatment period followed by a 7-day washout period for 3 different drugs. Block randomization was used to group dogs for treatments with drug A (gabapentin), B (tramadol), or C (meloxicam). Measurements of tear production, IOP, pupillary diameter, tear break-up time, and corneal touch threshold were performed on a schedule. A generalized mixed-effects linear regression model was created for each ocular variable, accounting for repeated measures within individuals. RESULTS: Intraocular pressure was the only variable to have differed substantially between the first 5 and last 2 days of the acclimation period. When treatment phase, day, time of day, dog identification, baseline value, and eye were accounted for, the mean IOP was lower for dogs during treatment phases with gabapentin or tramadol, compared with meloxicam, but this difference was not considered clinically meaningful. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that a minimum 5-day acclimation period is necessary for IOP measurements to return to baseline in dogs. The statistically identified effect of gabapentin and tramadol on IOP in dogs of the present study warrants further investigation. It is possible that at higher dosages, or in dogs with glaucoma, this effect may become clinically significant.


Assuntos
Tramadol , Animais , Estudos Cross-Over , Cães , Gabapentina , Pressão Intraocular , Meloxicam , Tonometria Ocular
15.
PLoS One ; 15(10): e0240421, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33031477

RESUMO

OBJECTIVE: To evaluate the microbial loading in aerosols produced after air-puff by non-contact tonometer (NCT) as well as the effect of alcohol disinfection on the inhibition of microbes and thus to provide suggestions for the prevention and control of COVID-19 in ophthalmic departments of hospitals or clinics during the great pandemics. METHODS: A cross-sectional study was carried out in this study. A NIDEK NCT was used for intraocular pressure (IOP) measurement for patients who visited Department of Ophthalmology in Qilu Hospital of Shandong University during March 18-25 2020. After ultra-violate (UV) light disinfection, the room air was sampled for 5 minutes. Before and after alcohol disinfection, the air samples and nozzle surface samples were respectively collected by plate exposure method and sterile moist cotton swab technique after predetermined times of NCT air-puff. Microbial colony counts were calculated after incubation for 48 hours. Finally, mass spectrometry was performed for the accurate identification of microbial species. RESULTS: Increased microbial colonies were detected from air samples close to NCT nozzle after air-puff compared with air samples at a distance of 1 meter from the nozzle (p = 0.001). Interestingly, none microbes were detected on the surface of NCT nozzle. Importantly, after 75% alcohol disinfection less microbes were detected in the air beside the nozzle (p = 0.003). Microbial species identification showed more than ten strains of microbes, all of which were non-pathogenic. CONCLUSION: Aerosols containing microbes were produced by NCT air-puff in the ophthalmic consultation room, which may be a possible virus transmission route in the department of ophthalmology during the COVID-19 pandemic. Alcohol disinfection for the nozzle and the surrounding air was efficient at decreasing the microbes contained in the aerosols and theoretically this prevention measure could also inhibit the virus. This will give guidance for the prevention of virus transmission and protection of hospital staff and patients.


Assuntos
Microbiologia do Ar , Álcoois/química , Infecções por Coronavirus/prevenção & controle , Desinfetantes/química , Pandemias/prevenção & controle , Pneumonia Viral/prevenção & controle , Tonometria Ocular/métodos , Aerossóis/química , Betacoronavirus/fisiologia , China/epidemiologia , Infecções por Coronavirus/epidemiologia , Estudos Transversais , Hospitais , Humanos , Oftalmologia/métodos , Pneumonia Viral/epidemiologia
16.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 4212-4216, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018926

RESUMO

Frequent and accurate monitoring of intraocular pressure is an important aspect of glaucoma management and is central to timely therapeutic intervention and treatment optimization. Intraocular pressure is known to fluctuate not only throughout the day, but also as a function of the heart rate. This pulsatory pressure change behavior is known as the ocular pulse. In this study, we report on the measurement of the ocular pulse profile using a miniaturized intraocular pressure sensor implanted in the eye of a New Zealand White rabbit. The pressure sensor is based on the principle of interferometry and does not require an internal power source. The ocular pulse variation has been measured up to 5 Hz with an accuracy of +/- 0.15 mmHg using both a DSLR reader and a handheld smartphone reader.


Assuntos
Glaucoma , Pressão Intraocular , Animais , Olho , Glaucoma/diagnóstico , Frequência Cardíaca , Coelhos , Tonometria Ocular
17.
Cesk Slov Oftalmol ; 76(2): 68-76, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33126801

RESUMO

AIMS: To investigate the effect of intracameral triamcinolone acetonide (TA) on surgical success in 5-fluorouracil (5-FU) supported primary phacotrabeculectomy (PT) cases. MATERIAL AND METHODS: This retrospective study included 23 eyes (study group) of 23 patients who underwent TA during PT and 26 eyes (control group) of 26 patients without TA. PT patients in the study group received 1 mg TA intraoperatively at the end of surgery. Pre- and postoperative visual acuity, intraocular pressure (IOP), and number of antiglaucoma drugs used were compared. Postoperative complications and need for 5-FU injection were evaluated for both groups. RESULTS: Mean age was 64.1 2 ± 1.91 (48-86) years in the control group and 66.52 ± 2.02 (52-86) years in the study group (p = 0.824). Comparison of pre- and postoperative IOP values showed significant decreases in postoperative IOP levels at all-time points in both the control and study groups (p < 0.001). The only significant difference between groups was on postoperative first day (study group: 9.22 ± 1.41 mmHg; control group: 6.35 ± 2.17 mmHg, p < 0.001). Need for postoperative 5-FU injection was significantly more common in the control group (p = 0.023). CONCLUSION: Intracameral injection of 1 mg TA at the end of PT surgery did not yield superior results in postoperative IOP compared to PT alone, and the two groups showed similar IOP reduction. When given as an adjunct to PT, 1 mg TA suppresses anterior segment inflammation and reduces the need for 5-FU injection.


Assuntos
Trabeculectomia , Triancinolona Acetonida , Idoso , Estudos de Casos e Controles , Humanos , Pressão Intraocular , Pessoa de Meia-Idade , Estudos Retrospectivos , Tonometria Ocular , Resultado do Tratamento
18.
Vestn Oftalmol ; 136(6): 100-107, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33084286

RESUMO

Currently, the level of intraocular pressure (IOP) can be assessed with a large number of tonometers, which differ in the principle of action, the place of application and the degree of invasiveness. All the methods in use - except for direct manometry - allow only indirect judgement of the level of ophthalmotonus. The quality of tonometric measurement is influenced by many factors, from the choice of tonometer to the analysis of the results obtained by the doctor. The use of complex methods for assessing the level of intraocular pressure provides additional information that increases its diagnostic value. This article summarizes current information about modern methods of tonometry, and describes their features.


Assuntos
Médicos , Tonometria Ocular , Humanos , Pressão Intraocular , Manometria
19.
Vestn Oftalmol ; 136(6): 113-120, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33084288

RESUMO

Nowadays glaucoma is one of the leading causes of irreversible blindness worldwide. The main goal in preservation of vision in glaucoma patients is reducing intraocular pressure (IOP), which is considered the main controlled risk factor for progression of glaucomatous optic neuropathy. The article discusses the effectiveness and safety of various transscleral laser technologies in the treatment of glaucoma. Modern transscleral laser technologies that affect the uveoscleral drainage and scleral hydro-permeability are less traumatic and more gentle making them promising in the treatment of patients with early stages of glaucoma, and not only in terminal glaucoma with pain syndrome resistant to conventional treatment ("last resort surgery").


Assuntos
Glaucoma , Terapia a Laser , Terapia com Luz de Baixa Intensidade , Glaucoma/diagnóstico , Glaucoma/cirurgia , Humanos , Pressão Intraocular , Tonometria Ocular
20.
Vestn Oftalmol ; 136(5): 32-38, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33056961

RESUMO

Modern tonometers (Ocular Response Analyzer) can only show the presence of biomechanical disorders of the fibrous membrane, while elastotonometry reacts not only to their presence, but also to their type. PURPOSE: To build a mathematical model that would use elastotonometry to assess biomechanical properties of the eye in treatment of hyperopia with LASIK and FemtoLASIK surgeries. MATERIAL AND METHODS: The study included 64 operations: 34 FemtoLASIK surgeries, and 31 LASIK surgeries. All patients before and after surgery underwent standard examination necessary for keratorefractive surgery, including elastotonometry. The next step was the analysis of elastotonometry curves and eye finite element model in the software package Ansys (Ansys, Inc.; U.S.A.). During the analysis, the fibrous membrane was modeled by two spherical segments, which before elastotonometry were influenced only by true intraocular pressure (IOP). There was a problem of determining tonometric IOP when the cornea is pressured with flat bottomed loads during elastotonometry. It was taken into account that at the first stage of loading, the IOP was applied, and then the force corresponding to the weight of the tonometer. After tonometry, IOP increased so that the volume inside the composite membrane corresponded to the value before loading. RESULTS: Mathematical modeling has shown that after surgical treatment of hyperopia, flexural stiffness of the cornea decreases, elevation of the elastotonometry curve increases, and the higher the true IOP, the greater the elevation. The greatest increase in lift due to increased IOP is observed after LASIK operation, while after FemtoLASIK this change is not significant, in which case the dependence of tonometric IOP on the weight of the load is almost linear. CONCLUSION: The obtained results allow for elastotonometry to be recommend for further medical research as a promising method for assessing biomechanical characteristics of the fibrous membrane of the eye.


Assuntos
Hiperopia , Ceratomileuse Assistida por Excimer Laser In Situ , Córnea/cirurgia , Humanos , Hiperopia/diagnóstico , Hiperopia/etiologia , Hiperopia/cirurgia , Pressão Intraocular , Ceratomileuse Assistida por Excimer Laser In Situ/efeitos adversos , Tonometria Ocular
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