Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 20.281
Filtrar
1.
BMJ Case Rep ; 14(1)2021 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-33431454

RESUMO

In this paper, we report the psychological and emotional experience of a patient who regained vision after over a decade of vision loss. The negative psychological implications of blindness are well recognised and there is a robust link between visual impairment and low mood and depressive symptoms. Although uncommon, low mood and depressive symptoms have been reported in patients whose sight has been restored, and lack of research gives rise to the possibility their prevalence may be grossly under-recognised in such patient groups. The effects can be so severe that patients may revert to living in darkness in mimicry of their previous lifestyle, effectively obviating the sight-restoring surgery. Healthcare professionals have a responsibility to address this traditionally neglected need by facilitating social, psychological and medical interventions that may ease the return to vision.


Assuntos
Transtornos de Adaptação/etiologia , Cegueira/cirurgia , Transplante de Córnea/psicologia , Depressão/etiologia , Complicações Pós-Operatórias/psicologia , Transtornos de Adaptação/psicologia , Transtornos de Adaptação/reabilitação , Adulto , Cegueira/psicologia , Cegueira/reabilitação , Depressão/diagnóstico , Depressão/psicologia , Depressão/reabilitação , Humanos , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/reabilitação , Fatores de Tempo , Resultado do Tratamento , Visão Ocular
2.
Adv Exp Med Biol ; 1293: 141-151, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33398811

RESUMO

Animal opsin-based pigments are light-activated G-protein-coupled receptors (GPCRs), which drive signal transduction cascades via G-proteins. Thousands of animal opsins have been identified, and molecular phylogenetic and biochemical analyses have revealed the unexpected diversity in selectivity of G-protein activation and photochemical property. Here we discuss the optogenetic potentials of diverse animal opsins, particularly recently well-characterized three non-canonical opsins, parapinopsin, peropsin, and LWS bistable opsin. Unlike canonical opsins such as vertebrate visual opsins that have been conventionally used for optogenetic applications, these opsins are bistable; opsin-based pigments do not release the chromophore retinal after light absorption, and the stable photoproducts revert to their original dark states upon subsequent light absorption. Parapinopsins have a "complete photoregeneration ability," which allows a clear color-dependent regulation of signal transductions. On the other hand, peropsins serve as a "dark-active and light-inactivated" GPCR to regulate signal transductions in the opposite way compared with usual opsins. In addition, an LWS bistable opsin from a butterfly was revealed to be the longest wavelength-sensitive animal opsin with its absorption maximum at ~570 nm. The property-dependent optical regulations of signal transductions were demonstrated in mammalian cultured cells, showing potentials of new optogenetic tools.


Assuntos
Opsinas , Optogenética , Animais , Evolução Molecular , Opsinas/genética , Opsinas/efeitos da radiação , Vertebrados , Visão Ocular/efeitos da radiação
3.
Adv Exp Med Biol ; 1293: 545-555, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33398841

RESUMO

The loss of photoreceptor cells caused by retinal degenerative diseases leads to blindness. The optogenetic approach for restoring vision involves converting the surviving inner retinal neurons into photosensitive cells, thus imparting light sensitivity to the retina following the loss of photoreceptor cells. Our first demonstration of the feasibility of such an approach involved expressing ChR2 in the retinal ganglion cells of blind mice; since then, optogenetic vision restoration has been demonstrated by using a variety of optogenetic tools, especially microbial channelrhodopsins (ChRs). A ChR-based optogenetic therapy for treating blindness has advanced to clinical trials. In this chapter, we review our early proof-of-concept study of optogenetic vision restoration. We also discuss our studies for developing better ChR tools and for restoring intrinsic visual processing features in retinas with degenerated photoreceptors.


Assuntos
Optogenética , Degeneração Retiniana , Animais , Channelrhodopsins , Camundongos , Retina , Degeneração Retiniana/genética , Degeneração Retiniana/terapia , Células Ganglionares da Retina , Visão Ocular
4.
Arq Bras Oftalmol ; 84(1): 17-21, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33470337

RESUMO

PURPOSE: To compare the severity and laterality of keratoconus according to allergic rhinitis, scratching and sleeping habits, and manual dexterity. METHODS: Objective assessments regarding allergic rhinitis, eye itching, and slee-ping position among patients with keratoconus (diagnosed based on corneal tomography) were conducted. Diagnostic criteria and classification were based on the Amsler-Krumeich classification. RESULTS: Ocular pruritus was reported by 29 of 34 participants (85.29%). Eighteen participants (62.07%) reported equal scratching of both eyes, six (20.69%) more on the right eye, and five (17.24%) more on the left eye. Comparison of the main sleeping position and the eye with more severe presentation of the disease using Fisher's exact test revealed some correlations (0.567 and 0.568 in the right and left eye, respectively). However, these correlations were not statistically significant. CONCLUSIONS: The association between higher keratometry values and sleeping position appears to be more significant than that reported between keratometry and itching, or manual dexterity.


Assuntos
Hipersensibilidade , Ceratocone , Córnea , Topografia da Córnea , Humanos , Ceratocone/diagnóstico , Visão Ocular
5.
Science ; 371(6525)2021 01 08.
Artigo em Inglês | MEDLINE | ID: mdl-33414193

RESUMO

The ability to perceive and interact with the world depends on a diverse array of neural circuits specialized for carrying out specific computations. Each circuit is assembled using a relatively limited number of molecules and common developmental steps, from cell fate specification to activity-dependent synaptic refinement. Given this shared toolkit, how do individual circuits acquire their characteristic properties? We explore this question by comparing development of the circuitry for seeing and hearing, highlighting a few examples where differences in each system's sensory demands necessitate different developmental strategies.


Assuntos
Vias Auditivas/embriologia , Núcleo Coclear/embriologia , Neurogênese , Retina/embriologia , Vias Visuais/embriologia , Animais , Audição/fisiologia , Camundongos , Células Receptoras Sensoriais/ultraestrutura , Sinapses/ultraestrutura , Visão Ocular/fisiologia
7.
Biomed Pharmacother ; 133: 111092, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33378986

RESUMO

This review provides insights into the mechanism underlying the pathogenesis of myopia and potential targets for clinical intervention. Although the etiology of myopia involves both environmental and genetic factors, recent evidence has suggested that the prevalence and severity of myopia appears to be affected more by environmental factors. Current pharmacotherapeutics are aimed at inhibiting environmentally induced changes in visual input and subsequent changes in signaling pathways during myopia pathogenesis and progression. Recent studies on animal models of myopia have revealed specific molecules potentially involved in the regulation of eye development. Among them, the dopamine receptor plays a critical role in controlling myopia. Subsequent studies have reported pharmacotherapeutic treatments to control myopia progression. In particular, atropine treatment yielded favorable outcomes and has been extensively used; however, current studies are aimed at optimizing its efficacy and confirming its safety. Furthermore, future studies are required to assess the efficacy of combinatorial use of low-dose atropine and contact lenses or orthokeratology.


Assuntos
Olho/efeitos dos fármacos , Miopia/tratamento farmacológico , Visão Ocular/efeitos dos fármacos , Animais , Modelos Animais de Doenças , Olho/metabolismo , Olho/fisiopatologia , Humanos , Miopia/metabolismo , Miopia/fisiopatologia , Transdução de Sinais , Resultado do Tratamento
8.
J Stroke Cerebrovasc Dis ; 30(2): 105531, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33310593

RESUMO

OBJECTIVES: Acute central retinal artery occlusion (CRAO) is an ophthalmologic emergency that often results in permanent vision loss. Over 25% are associated with acute cerebral ischemia. In the absence of existing Level I treatment options, this study aims to examine institutional practice patterns and review the literature to develop a formalized approach to the treatment of CRAO in the era of ischemic stroke protocols. MATERIALS AND METHODS: This is a retrospective review of institutional practices in the workup and treatment of patients diagnosed with acute non-arteritic (NA) CRAO at a single center from January 2017 to August 2020. RESULTS: Of 91 patients managed for acute NA-CRAO, 62.6% were male and average age was 66.4 years. Only 20.9% of patients presented within 4 h of symptom onset. 12.1% of patients had evidence of acute stroke on MRI, and 27.5% had ipsilateral internal carotid artery stenosis >50%. Half (52.7%) did not receive any acute treatment for CRAO, excluding antiplatelet/anticoagulation. 48.5% of patients undergoing acute medical treatment had improved visual acuity compared to 29.4% without treatment (p=0.14). CONCLUSIONS: There is a lack of clear protocol for the management of NA-CRAO. While not reaching statistical significance, our experience mirrors the literature with patients undergoing medical treatment demonstrating improved visual acuity over those without treatment. Given the presence of acute ischemic stroke, carotid disease, and/or stroke risk factors in over 25% of patients with CRAO, multidisciplinary involvement and modern stroke algorithms should be considered for this disease.


Assuntos
Estenose das Carótidas/terapia , Oclusão da Artéria Retiniana/terapia , Visão Ocular , Idoso , Estenose das Carótidas/diagnóstico por imagem , Estenose das Carótidas/epidemiologia , Estenose das Carótidas/fisiopatologia , Tomada de Decisão Clínica , Feminino , Humanos , /epidemiologia , Masculino , Recuperação de Função Fisiológica , Oclusão da Artéria Retiniana/diagnóstico por imagem , Oclusão da Artéria Retiniana/epidemiologia , Oclusão da Artéria Retiniana/fisiopatologia , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Resultado do Tratamento
9.
PLoS One ; 15(12): e0238554, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33382696

RESUMO

Previous work has shown that symmetrical stimuli are judged as lasting longer than asymmetrical ones, even when actual duration is matched. This effect has been replicated with different methods and stimuli types. We aimed to a) replicate the effect of symmetry on subjective duration, and b) assess whether it was further modulated by the number of symmetrical axes. There was no evidence for either effect. This null result cannot be explained by reduced statistical power or enhanced floor or ceiling effects. There is no obvious stimulus-based explanation either. However, we are mindful of the reproducibility crisis and file drawer problems in psychology. Other symmetry and time perception researchers should be aware of this null result. One possibility is that the effect of symmetry on subjective duration is limited to very specific experimental paradigms.


Assuntos
Percepção de Forma/fisiologia , Reconhecimento Visual de Modelos/fisiologia , Percepção do Tempo/fisiologia , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Psicofísica , Reprodutibilidade dos Testes , Visão Ocular/fisiologia
10.
PLoS One ; 15(12): e0240201, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33382720

RESUMO

Driving is an everyday task involving a complex interaction between visual and cognitive processes. As such, an increase in the cognitive and/or visual demands can lead to a mental overload which can be detrimental for driving safety. Compiling evidence suggest that eye and head movements are relevant indicators of visuo-cognitive demands and attention allocation. This study aims to investigate the effects of visual degradation on eye-head coordination as well as visual scanning behavior during a highly demanding task in a driving simulator. A total of 21 emmetropic participants (21 to 34 years old) performed dual-task driving in which they were asked to maintain a constant speed on a highway while completing a visual search and detection task on a navigation device. Participants did the experiment with optimal vision and with contact lenses that introduced a visual perturbation (myopic defocus). The results indicate modifications of eye-head coordination and the dynamics of visual scanning in response to the visual perturbation induced. More specifically, the head was more involved in horizontal gaze shifts when the visual needs were not met. Furthermore, the evaluation of visual scanning dynamics, based on time-based entropy which measures the complexity and randomness of scanpaths, revealed that eye and gaze movements became less explorative and more stereotyped when vision was not optimal. These results provide evidence for a reorganization of both eye and head movements in response to increasing visual-cognitive demands during a driving task. Altogether, these findings suggest that eye and head movements can provide relevant information about visuo-cognitive demands associated with complex tasks. Ultimately, eye-head coordination and visual scanning dynamics may be good candidates to estimate drivers' workload and better characterize risky driving behavior.


Assuntos
Atenção/fisiologia , Condução de Veículo/psicologia , Movimentos Oculares/fisiologia , Movimentos da Cabeça/fisiologia , Desempenho Psicomotor , Adulto , Cognição/fisiologia , Feminino , Humanos , Masculino , Assunção de Riscos , Treinamento por Simulação , Visão Ocular/fisiologia
11.
Proc Biol Sci ; 287(1941): 20202315, 2020 12 23.
Artigo em Inglês | MEDLINE | ID: mdl-33323087

RESUMO

Background-matching camouflage is a widespread adaptation in animals; however, few studies have thoroughly examined its evolutionary process and consequences. The tiger beetle Chaetodera laetescripta exhibits pronounced variation in elytral colour pattern among sandy habitats of different colour in the Japanese Archipelago. In this study, we performed digital image analysis with avian vision modelling to demonstrate that elytral luminance, which is attributed to proportions of elytral colour components, is fine-tuned to match local backgrounds. Field predation experiments with model beetles showed that better luminance matching resulted in a lower attack rate and corresponding lower mortality. Using restriction site-associated DNA (RAD) sequence data, we analysed the dispersal and evolution of colour pattern across geographical locations. We found that sand colour matching occurred irrespective of genetic and geographical distances between populations, suggesting that locally adapted colour patterns evolved after the colonization of these habitats. Given that beetle elytral colour patterns presumably have a quantitative genetic basis, our findings demonstrate that fine-tuning of background-matching camouflage to local habitat conditions can be attained through selection by visual predators, as predicted by the earliest proponent of natural selection.


Assuntos
Mimetismo Biológico/fisiologia , Besouros/fisiologia , Pigmentação/fisiologia , Aclimatação , Adaptação Fisiológica , Animais , Evolução Biológica , Aves , Cor , Ecossistema , Comportamento Predatório , Seleção Genética , Tubarões , Visão Ocular
12.
Biol Lett ; 16(12): 20200786, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-33321068

RESUMO

Visual attention plays a fundamental role in avian flight but attention is likely limited whenever birds blink. Because blinks are necessary to maintaining proper vision, this study tested the hypothesis that birds strategically inhibit their blinks in flight. The blinks of captive great-tailed grackles (Quiscalus mexicanus) were recorded before, during and after they flew a short distance in an open environment. The grackles spent the least amount of time blinking in flight (take-off, during flight and landing) and the most amount of time blinking at impact. Their blinking behaviour was similar before and after flight. These results suggest that grackles strategically inhibit their blinking behaviour in flight, potentially because blinks impose costs to avian flight.


Assuntos
Passeriformes , Aves Canoras , Animais , Piscadela , Visão Ocular
13.
Zhonghua Yan Ke Za Zhi ; 56(11): 811-814, 2020 Nov 11.
Artigo em Chinês | MEDLINE | ID: mdl-33152839

RESUMO

Visual electrophysiological examination, which features the advantage of being objective, noninvasive and quantitative, is an important method for visual function assessment. The problem yet to be resolved in clinical and medical authentication, is the standardization of application, particularly in terms of test procedure and results interpretation. Visual electrophysiology examination includes many tests. Each kind of test has its own clinical significance. There are many factors that may affect results. Therefore, the standardization in the examination procedure can ensure the accuracy and repeatability of the result. The interpretation of the report, which relies upon both clinical operation guidance and clinical experiences, also needs to be standardized. Focus should be put on the issues above in an effort to realize the reasonable application of visual electrophysiology in clinic diagnosis and medical authentication, and to avoid the misjudgment or misdiagnosis. (Chin J Ophthalmol, 2020, 56: 811-814).


Assuntos
Fenômenos Eletrofisiológicos , Visão Ocular , Eletrofisiologia , Humanos
15.
PLoS One ; 15(10): e0240036, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33007038

RESUMO

OBJECTIVES: To assess the effects of different types of cataract surgeries and intraocular lenses on generic as well as vision related quality of life of cataract patients, using EQ-5D and IND-VFQ 33 instruments respectively. METHODS: An observational, longitudinal study of patients undergoing cataract surgery was carried out at three ophthalmology centres. Patients were prospectively admitted for surgery for age-related cataract. Generic quality of life was assessed by using Euroqol's EQ5D-5L questionnaire and vision related quality of life was assessed by the IND-VFQ-33 questionnaire. Data pertaining to vision function and quality of life were collected pre surgery and 4 weeks after the surgery. RESULTS: Out of total patients (n = 814) recruited for the study, 517 patients were interviewed for both pre-surgery and post-surgery for EQ5D and 519 patients were interviewed for both pre-surgery and post-surgery for IND VFQ 33 tool. The combined data from all three centres showed that Quality Adjusted Life Year (QALY) gains observed in patients undergoing phacoemulsification with foldable lens implantation (2.25 QALY) were significantly higher (0.57 QALY) as compared to Small Incision Cataract Surgery (SICS) with PMMA lens implantation (1.68 QALY). Highest improvement however, in all three subscales of IND-VFQ-33 tool were clearly observed for SICS with PMMA lens implantation. CONCLUSIONS: The study has elicited the Health related and vision related Quality of Life scores for cataract surgeries and subsequent lens implantation. This study also offers Health State Utility Values along with visual outcomes for different surgical procedures, lenses and for the combination of surgery with lens implantation for cataract procedures providing a useful resource for future economic evaluation studies.


Assuntos
Extração de Catarata , Implante de Lente Intraocular , Qualidade de Vida , Visão Ocular , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
16.
Curr Opin Ophthalmol ; 31(6): 475-482, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33009079

RESUMO

PURPOSE OF REVIEW: Recent studies have increased our understanding of the biochemical and structural bases of visual hallucinations in patients with a variety of underlying causes. RECENT FINDINGS: Visual hallucinations may be related to disruption of functional connectivity networks, with underlying biochemical dysfunction such as decreased in cholinergic activity. Structural abnormalities in primary and higher order visual processing areas also have been found in patients with visual hallucinations. The occurrence of visual hallucinations after vision loss, the Charles Bonnet syndrome, may have more functional similarity to psychiatric and neurodegenerative causes than previously suspected despite retained insight into the unreal nature of the phenomena. SUMMARY: Visual hallucinations are common, and patients may not report them if specific inquiries are not made. Presence or absence of hallucinations may be of diagnostic and therapeutic importance, especially in patients with neurodegenerative conditions that have overlapping features. Treatment of visual hallucinations remains challenging and must be tailored to each patient based on the underlying cause and comorbid conditions.


Assuntos
Alucinações , Animais , Cognição , Alucinações/diagnóstico , Alucinações/etiologia , Alucinações/psicologia , Alucinações/terapia , Humanos , Corpos de Lewy , Visão Ocular
17.
J Stroke Cerebrovasc Dis ; 29(11): 105186, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33066925

RESUMO

BACKGROUND/OBJECTIVES: Stroke-related visual impairment and atrial fibrillation are both common following stroke. This study explores whether presence of visual impairment following stroke is associated with presence of atrial fibrillation (AF). SUBJECTS/METHODS: The Impact of Visual Impairment after Stroke (IVIS) study is a multi-centre, acute stroke unit, prospective epidemiology study. Standardised visual assessments included visual acuity, reading, visual fields, eye movements and visual perception. AF and blood pressure (BP) were measured on admission. Further data capture included stroke type, age, gender, stroke severity. Analysis included descriptive statistics, independent samples analysis and multivariate analysis for comparison of AF and visual impairment against covariates. RESULTS: 1500 stroke admissions were recruited of which 1204 stroke survivors had visual assessment. New onset stroke-related visual impairment (n = 703) was significantly associated with older age and stoke severity. AF and BP data were available for 889 stroke survivors. AF was present on admission for 258 stroke survivors and significantly associated with older age, stroke severity and discharge destination. A significant association was found for presence of AF and presence of visual impairment. However, stroke severity was a contributing factor for this association. High systolic BP (>140 mmHg) was present in 62% and high diastolic BP (>90 mmHg) in 29%, but not associated with presence of visual impairment. CONCLUSIONS: AF and visual impairment, independently, occur commonly in stroke. Although our results show an association between AF and visual impairment, this appears to be independently influenced by stroke severity. AF was not associated with type of visual impairment or extent of visual recovery. It remains unknown if AF causes more severe visual impairment.


Assuntos
Fibrilação Atrial/epidemiologia , Acidente Vascular Cerebral/epidemiologia , Transtornos da Visão/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Fibrilação Atrial/diagnóstico , Fibrilação Atrial/fisiopatologia , Pressão Sanguínea , Inglaterra/epidemiologia , Feminino , Frequência Cardíaca , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Medição de Risco , Fatores de Risco , Índice de Gravidade de Doença , Acidente Vascular Cerebral/diagnóstico , Acidente Vascular Cerebral/fisiopatologia , Transtornos da Visão/diagnóstico , Transtornos da Visão/fisiopatologia , Visão Ocular , Acuidade Visual
18.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 3347-3350, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018721

RESUMO

During human standing, it has been previously observed that information about the position and frequency of visual surround motion improves balance by reducing sway responses to external disturbances. However, experimental limitations only allowed for independent investigation of such parameters while being incapable of providing a fully immersive experience of a real environment. The aim of this study is to investigate the effect of visual information on dynamic body sway in the human upright stance by presenting perturbations through a virtual reality (VR) system. Moreover, we designed a new perturbation signal based on trapezoidal velocity (TrapV) pulses enabling us to simultaneously examine the effects of amplitude and velocity on balance control. The experiments included four different peak-to-peak amplitudes (1-10 degrees), and three velocities (2-10 degree/sec). The body angle, ankle torques and shank angles were measured and analyzed in response to each perturbation. The results reveal that stimuli with higher amplitudes evoked larger responses, while they were initially increased and reached a peak, then decreased by increasing the motion velocity of visual surround.


Assuntos
Realidade Virtual , Fenômenos Biomecânicos , Humanos , Equilíbrio Postural , Posição Ortostática , Visão Ocular
19.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 3913-3916, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018856

RESUMO

Since the 70s sensory substitution devices have been used for blind individuals to compensate for the lack of vision and enable them to perceive environment through intact sensory modalities. In this study, we present a rehabilitation device called Audio Visual Thumble (AVT), which is a small ring-like device with LED and buzzer, that can be worn on pharynx. We focus on a unique group of low-vision individuals with a black spot or scotoma in their visual field due to a disease called Macular Degeneration. The visual localization abilities of these individuals are highly impaired due to developing scotoma. We recently showed that also their audio localization skills are impaired [9]. Rehabilitation techniques developed so far for Macular Degeneration focus on visual modality only. Since audition can also be used to improve their spatial skills, we developed the AVT device. It permits to associate the multisensory information (audio and visual feedbacks) coming from the device with the own movement (proprioceptive feedback). We propose that the AVT has the potential to help people with visual dysfunctions to improve in the identification of audio and visual targets outside or at the edge of the residual visual field. AVT could be used for a wide range of applications combined with classical rehabilitation techniques in Macular Degeneration patients.Clinical relevance- This device can be an effective addition for low-vision rehabilitation experts and can be used combined with classical rehabilitation methods.


Assuntos
Baixa Visão , Percepção Auditiva , Humanos , Escotoma , Visão Ocular , Campos Visuais
20.
PLoS One ; 15(10): e0240016, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33002047

RESUMO

Childhood craniopharyngioma is a rare and slow growing brain tumour, often located in the sellar and suprasellar region. It commonly manifests with visual impairment, increased intracranial pressure and hypothalamic and/or pituitary deficiencies. Visual impairment in childhood adversely affects a child's daily functioning and quality of life. We systematically reviewed the literature to provide an extensive overview of the visual function in children with craniopharyngioma at diagnosis in order to estimate the diversity, magnitude and relevance of the problem of visual impairment. Of the 543 potentially relevant articles, 84 studies met our inclusion criteria. Visual impairment at diagnosis was reported in 1041 of 2071 children (50.3%), decreased visual acuity was reported in 546 of 1321 children (41.3%) and visual field defects were reported in 426 of 1111 children (38.3%). Other ophthalmological findings described were fundoscopic (32.5%) and orthoptic abnormalities (12.5%). Variations in ophthalmological testing methods and ophthalmological definitions precluded a meta-analysis. The results of this review confirm the importance of ophthalmological examination in children with craniopharyngioma at diagnosis in order to detect visual impairment and provide adequate support. Future studies should focus on long-term visual follow-up of childhood craniopharyngioma in response to different treatment strategies to provide insight in risks and ways to prevent further loss of vision.


Assuntos
Craniofaringioma/fisiopatologia , Neoplasias Hipofisárias/fisiopatologia , Visão Ocular , Criança , Craniofaringioma/diagnóstico , Humanos , Neoplasias Hipofisárias/diagnóstico , Risco
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA