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MMWR Morb Mortal Wkly Rep ; 71(23): 764-769, 2022 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-35679181


On May 17, 2022, the Massachusetts Department of Public Health (MDPH) Laboratory Response Network (LRN) laboratory confirmed the presence of orthopoxvirus DNA via real-time polymerase chain reaction (PCR) from lesion swabs obtained from a Massachusetts resident. Orthopoxviruses include Monkeypox virus, the causative agent of monkeypox. Subsequent real-time PCR testing at CDC on May 18 confirmed that the patient was infected with the West African clade of Monkeypox virus. Since then, confirmed cases* have been reported by nine states. In addition, 28 countries and territories,† none of which has endemic monkeypox, have reported laboratory-confirmed cases. On May 17, CDC, in coordination with state and local jurisdictions, initiated an emergency response to identify, monitor, and investigate additional monkeypox cases in the United States. This response has included releasing a Health Alert Network (HAN) Health Advisory, developing interim public health and clinical recommendations, releasing guidance for LRN testing, hosting clinician and public health partner outreach calls, disseminating health communication messages to the public, developing protocols for use and release of medical countermeasures, and facilitating delivery of vaccine postexposure prophylaxis (PEP) and antivirals that have been stockpiled by the U.S. government for preparedness and response purposes. On May 19, a call center was established to provide guidance to states for the evaluation of possible cases of monkeypox, including recommendations for clinical diagnosis and orthopoxvirus testing. The call center also gathers information about possible cases to identify interjurisdictional linkages. As of May 31, this investigation has identified 17§ cases in the United States; most cases (16) were diagnosed in persons who identify as gay, bisexual, or men who have sex with men (MSM). Ongoing investigation suggests person-to-person community transmission, and CDC urges health departments, clinicians, and the public to remain vigilant, institute appropriate infection prevention and control measures, and notify public health authorities of suspected cases to reduce disease spread. Public health authorities are identifying cases and conducting investigations to determine possible sources and prevent further spread. This activity was reviewed by CDC and conducted consistent with applicable federal law and CDC policy.¶.

Malária , Monkeypox , Minorias Sexuais e de Gênero , Animais , Surtos de Doenças , Homossexualidade Masculina , Humanos , Malária/diagnóstico , Masculino , Monkeypox/diagnóstico , Monkeypox/epidemiologia , Vigilância da População , Viagem , Estados Unidos/epidemiologia
MMW Fortschr Med ; 164(11): 12, 2022 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-35650476

Monkeypox , Animais , Humanos
J Korean Med Sci ; 37(22): e188, 2022 06 06.
Artigo em Inglês | MEDLINE | ID: mdl-35668692

Monkeypox , Animais , Humanos
Euro Surveill ; 27(22)2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35656830


Up to 27 May 2022, Portugal has detected 96 confirmed cases of monkeypox. We describe 27 confirmed cases (median age: 33 years (range: 22-51); all males), with an earliest symptom onset date of 29 April. Almost all cases (n = 25) live in the Lisbon and Tagus Valley health region. Most cases were neither part of identified transmission chains, nor linked to travel or had contact with symptomatic persons or with animals, suggesting the possible previously undetected spread of monkeypox.

Vírus da Varíola dos Macacos , Monkeypox , Animais , Surtos de Doenças , Humanos , Masculino , Monkeypox/diagnóstico , Monkeypox/epidemiologia , Vírus da Varíola dos Macacos/genética , Portugal/epidemiologia , Viagem
Euro Surveill ; 27(22)2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35656835


Rapid diagnosis and whole genome sequencing confirmed a case of monkeypox in an HIV-positive individual receiving antiretroviral therapy. The patient had a normal CD4+ T-cell count and suppressed HIV viral load and presented with a genital rash in Melbourne, Australia after return from Europe in May 2022. He subsequently developed systemic illness and disseminated rash and 11 days after symptom onset, he was hospitalised to manage painful bacterial cellulitis of the genital area.

Exantema , Infecções por HIV , Monkeypox , Animais , Exantema/etiologia , Genitália , Infecções por HIV/complicações , Infecções por HIV/diagnóstico , Infecções por HIV/tratamento farmacológico , Humanos , Masculino , Monkeypox/diagnóstico , Carga Viral
MMWR Morb Mortal Wkly Rep ; 71(22): 734-742, 2022 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-35653347


Certain laboratorians and health care personnel can be exposed to orthopoxviruses through occupational activities. Because orthopoxvirus infections resulting from occupational exposures can be serious, the Advisory Committee on Immunization Practices (ACIP) has continued to recommend preexposure vaccination for these persons since 1980 (1), when smallpox was eradicated (2). In 2015, ACIP made recommendations for the use of ACAM2000, the only orthopoxvirus vaccine available in the United States at that time (3). During 2020-2021, ACIP considered evidence for use of JYNNEOS, a replication-deficient Vaccinia virus vaccine, as an alternative to ACAM2000. In November 2021, ACIP unanimously voted in favor of JYNNEOS as an alternative to ACAM2000 for primary vaccination and booster doses. With these recommendations for use of JYNNEOS, two vaccines (ACAM2000 and JYNNEOS) are now available and recommended for preexposure prophylaxis against orthopoxvirus infection among persons at risk for such exposures.

Monkeypox , Exposição Ocupacional , Orthopoxvirus , Varíola , Vacinas , Comitês Consultivos , Animais , Humanos , Imunização , Varíola/prevenção & controle , Estados Unidos/epidemiologia , Vacinação , Vírus Vaccinia
Euro Surveill ; 27(22)2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35656836


Since May 2022, an outbreak of monkeypox has been ongoing in non-endemic countries. We report four cases in Italy in young adult men reporting condomless sexual intercourse. The patients are in good clinical condition with no need for specific antiviral drugs. Biological samples from seminal fluid were positive for monkeypox viral DNA. For many other viruses found in semen there is no evidence of sexual transmission. The possibility of sexual transmission of monkeypox virus needs to be investigated.

Monkeypox , Animais , Surtos de Doenças , Humanos , Masculino , Vírus da Varíola dos Macacos , Sêmen , Comportamento Sexual , Adulto Jovem
CMAJ ; 194(24): E844, 2022 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-35654445
Euro Surveill ; 27(24)2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35713026


In May 2022, monkeypox outbreaks have been reported in countries not endemic for monkeypox. We estimated the monkeypox incubation period, using reported exposure and symptom-onset times for 18 cases detected and confirmed in the Netherlands up to 31 May 2022. Mean incubation period was 8.5 days (5th-95th percentiles: 4.2-17.3), underpinning the current recommendation to monitor or isolate/quarantine case contacts for 21 days. However, as the incubation period may differ between different transmission routes, further epidemiological investigations are needed.

Monkeypox , Animais , Surtos de Doenças , Humanos , Período de Incubação de Doenças Infecciosas , Monkeypox/diagnóstico , Monkeypox/epidemiologia , Vírus da Varíola dos Macacos , Países Baixos/epidemiologia
Lancet ; 399(10343): 2254-2255, 2022 06 18.
Artigo em Inglês | MEDLINE | ID: mdl-35717977