La publicación de los conjuntos de datos por medio de las revistas científicas: el caso de pensar en movimiento / A publicação de conjuntos de dados através de revistas científicas: o caso de Pensar en Movimiento / The publication of data sets through scientific journals: The case of Pensar en Movimiento

Varela-Briceño, M. (2023). La publicación de los conjuntos de datos por medio de las revistas científicas: el caso de Pensar en Movimiento. PENSAR EN MOVIMIENTO: Revista de Ciencias del Ejercicio y la Salud, 21(1), 1-6. La publicación científica ha evolucionado y con ellos las revistas académicas, desde sus inicios en versiones impresas y actualmente las electrónicas, lo cual ha llevado a una serie de cambios en los procesos de gestión. Es así que se han establecidos los movimientos del acceso y la ciencia abierta. El propósito de este editorial es hacer un recorrido sobre la publicación de conjuntos de datos, su importancia y ventajas; además de mostrar la iniciativa de Pensar en Movimiento de poner a disposición las bases de datos que acompañan los artículos de investigación.

Varela-Briceño, M. (2023). The publication of data sets through scientific journals: The case of Pensar en Movimiento. PENSAR EN MOVIMIENTO: Revista de Ciencias del Ejercicio y la Salud, 21(1), 1-6. Scientific publishing has evolved, and academic journals have evolved with it—initially in printed versions, and currently in electronic ones. This has resulted in a series of changes in management processes. For instance, the movements for open access and science have emerged. The purpose of this editorial is to present an overview of the publication of data sets, its importance and advantages, in addition to showing the initiative of Pensar en Movimiento to make available the data bases that go along with research articles.

Varela-Briceño, M. (2023). A publicação de conjuntos de dados através de revistas científicas: o caso de Pensar en Movimiento. PENSAR EN MOVIMIENTO: Revista de Ciencias del Ejercicio y de la Salud, 21(1), 1-6. A publicação científica evoluiu, e com ela as revistas acadêmicas; desde sua criação, em versões impressas, e atualmente eletrônicas, o que levou a uma série de mudanças nos processos de gestão. É assim que os movimentos de acesso e ciência aberta foram estabelecidos. O objetivo deste editorial é fazer uma jornada pela publicação de conjuntos de dados, sua importância e vantagens; além de mostrar a iniciativa da revista Pensar en Movimiento de disponibilizar as bases de dados que acompanham os artigos de pesquisa.

Práticas psicológicas nos Creas do interior do RS: o olhar de trabalhadoras(es) / Psychological practices on CREAS in the countryside of the state of Rio Grande do Sul: perspectives of workers / Prácticas psicológicas en CREAS en el interior de Rio Grande do Sul: perspectiva de trabajadoras/es

O presente texto tem o objetivo de explanar ações desempenhadas por psicólogas(os) trabalhadoras(es) dos Centros de Referência Especializados de Assistência Social (Creas), em situações de violência intrafamiliar, identificadas a partir do estude empírico realizado por mim, psicóloga pesquisadora, também trabalhadora de um Creas. Participaram da pesquisa doze psicólogas(os), trabalhadoras(es) destes centros, em sete municípios do interior do Rio Grande do Sul, onde foram realizadas, presencialmente, as entrevistas. A análise dos dados apontou para uma compreensão metodológica a partir de três dimensões já apontadas na bibliografia, sendo elas: a) Acolhida Inicial, que demonstra que esses profissionais geralmente iniciam suas práticas com uma família ou indivíduo indo ao encontro destes, buscando a vinculação dos mesmos com o serviço; b) Acompanhamento Especializado, onde essas(es) trabalhadoras(es) desenvolvem suas práticas com diversidade e criatividade, a partir de visitas domiciliares, trabalhos com grupos, indivíduos ou famílias, geralmente em conjunto com outros profissionais, principalmente assistentes sociais; c) Articulação com a Rede, onde se identificou um importante movimento para o trabalho em conjunto com outros serviços disponíveis no território. Por fim, as considerações finais indicam que ainda há um caminho a ser trilhado com relação à definição das práticas dos psicólogos no Creas. Porém, há muito que se falar a respeito de práticas que já estão ocorrendo. Assim, tornam-se relevantes as pesquisas acadêmicas nesse contexto, pois ao inserir os profissionais psicólogos trabalhadores da política, eles podem promover uma articulação entre a produção do fazer cotidiano e a reflexão teórica e acadêmica sustentada pelas pesquisas.(AU)

This study aims to explore the activities developed by psychologists from the Centros de Referência de Atenção Especializada (CREAS - Brazilian Specialized Social Assistance Reference Centers), regarding situations of intrafamily violence identified by me, the author, a research psychologist and, CREAS worker. Participants include 12 psychologists who work on such centers from 7 cities in the countryside of Rio Grande do Sul, Brazil, where the interviews were conducted in person. The data analysis pointed toward a methodological comprehension based on 3 dimensions that have already been mentioned in the literature: the Initial Approach, which shows that these workers usually initiate their practices with a family or an individual by going after them, seeking bond development with the service. The Specialized Follow-up, in which these workers develop their practices with diversity and creativity, through home visits and activities with group, family or individual, often with other workers, such as social assistance workers. And the Network Articulation, in which a significant movement toward working with the public services available on each territory is identified. Finally, there is still a path to be taken regarding the definition of psychological practices on CREAS, however, there is much to be noticed of what has already been occurring. Thus, academic research on such context is relevant since the inclusion of psychologists who work in this policy may promote an articulation between daily activity and the theoretical and academic reflection, supported by the research.(AU)

Este texto tuvo por objetivo explicar las acciones desarrolladas por psicólogas/os trabajadoras/es en los "Centros de Referência Especializados de Assistência Social" (CREAS) (Centros de Referencia Especializados en Asistencia Social), respecto a las situaciones de violencia intrafamiliar, identificadas por un estudio empírico hecho por una psicóloga-investigadora que actúa en un CREAS. Participaron 12 psicólogas/os que trabajan en estos centros, en siete ciudades del interior de Rio Grande do Sul (Brasil), donde se llevó a cabo las entrevistas en persona. El análisis de datos apuntó a una comprensión metodológica de tres dimensiones ya destacadas en la bibliografía: la Acogida Inicial, que enseña que estos profesionales generalmente empiezan sus prácticas con una familia o individuo buscando el encuentro para la promoción de la vinculación con el servicio; El Seguimiento Especializado, en el que desarrollan sus prácticas con diversidad y creatividad desde visitas domiciliarias, trabajos con grupos, individuos o familias, generalmente junto a otros profesionales, sobre todo con trabajadores sociales; y Articulación con la Red de Servicios, en la cual se identificó un importante movimiento para el trabajo con otros servicios disponibles en el territorio. Por fin, se observa que todavía hay un camino por recorrer en relación a la definición de las prácticas de psicólogos en CREAS, aunque hay mucho que decir respecto a las prácticas que ya están ocurriendo. Así, se vuelven relevantes las investigaciones académicas en ese contexto por introducir a los profesionales psicólogos trabajadores de la política, las cuales pueden promover una articulación entre la producción del hacer cotidiano y la reflexión teórica y académica sustentada por las investigaciones.(AU)

Respiratory viruses surveillance country, territory and area profiles, 2021

The data in these profiles were submitted by the country, territory or area during the period July 2021 to December 2021.

Directiva administrativa que establece la trama de datos y el procedimiento para el envío de información sobre el stock y consumo del oxígeno medicinal realizado por las IPRESS y UGIPRESS públicas, privadas o mixtas. Directiva administrativa Nº 318-MINSA/DIGEMID-2021 / Administrative directive that establishes the data frame and the procedure for sending information on the stock and consumption of medicinal oxygen carried out by the public, private or mixed IPRESS and UGIPRESS. Administrative Directive No. 318-MINSA / DIGEMID-2021

El documento establece la trama de datos y el procedimiento para el envío diario de la información sobre el stock y consumo del oxígeno medicinal, realizadas por las IPRESS y IGIPRESS públicas, privadas o mixtas que gestionan oxígeno medicinal, a través del Registro Nacional del Oxígeno Medicinal en el Perú - RENOXI Perú, dispuesto por el Minsa.

Reflexões sobre o viés de publicação: um guia para praticantes de estatística para a análise de dados e uso inapropriado do coeficiente de correlação em ciências da saúde / Reflexions on publication bias: a guide for statisticians practitioners to data analysis and critical use of correlation coefficient in health sciences

A utilização de procedimentos estatísticos é de fundamental importância para a interpretação apropriada de um conjunto de dados. Desta forma, a baixa aderência do teste aos dados selecionados pode levar a conclusões inadequadas. Portanto, a escolha do teste paramétrico e não paramétrico para dados pareados deve levar em conta a normalidade dos dados. Com isso, aplicar o coeficiente de correlação de Pearson (teste paramétrico) em dados não paramétricos aumenta as chances de associações espúrias (por acaso ou erro sistemático), as quais resultam em erro do Tipo I. Entendendo que as vezes o pensamento do jovem pesquisador e também de editores de periódicos científicos serão guiados por resultados positivos. É comum a possibilidade de editores selecionarem artigos para publicação tendo como base o valor de p <0,05. Contudo, também seria importante selecionar os artigos levando em consideração os cumprimentos dos pressupostos para a utilização de testes paramétricos e não-paramétricos. Com isso, objetivo do presente estudo foi abordar os dois testes de coeficiente de correlação de Pearson e Spearman e sugerir recomendações para praticantes de estatística na área de Ciências da Saúde para a utilização segura e adequada dos dados antes da publicação.(AU)

The use of statistical procedures is of fundamental importance for the proper interpretation of data analysis. In this way, the low adherence of the test to the selected data can lead to inadequate conclusions. Therefore, the choice of parametric and non-parametric tests for paired data should take into account the normality of the data. Therefore, applying the Pearson correlation coefficient (non-parametric test) in non-parametric data increases the chances of spurious associations (by chance or systematic error), which result in a Type I error. Knowing that young researcher and editors of scientific journals might be guided by positive results. It is common for editors to select articles for publication based on p < 0.05 value. However, it would also be important to select papers taking into account the fulfillment of the assumptions for the use of parametric and non-parametric tests. Thus, the aim of the present study was to address the two Pearson and Spearman correlation coefficient tests and to suggest recommendations for practitioners of statistics in the area of Health Sciences for the safe and adequate use of data prior publication.(AU)

Feasibility of fully automated classification of whole slide images based on deep learning

Although microscopic analysis of tissue slides has been the basis for disease diagnosis for decades, intra- and inter-observer variabilities remain issues to be resolved. The recent introduction of digital scanners has allowed for using deep learning in the analysis of tissue images because many whole slide images (WSIs) are accessible to researchers. In the present study, we investigated the possibility of a deep learning-based, fully automated, computer-aided diagnosis system with WSIs from a stomach adenocarcinoma dataset. Three different convolutional neural network architectures were tested to determine the better architecture for tissue classifier. Each network was trained to classify small tissue patches into normal or tumor. Based on the patch-level classification, tumor probability heatmaps can be overlaid on tissue images. We observed three different tissue patterns, including clear normal, clear tumor and ambiguous cases. We suggest that longer inspection time can be assigned to ambiguous cases compared to clear normal cases, increasing the accuracy and efficiency of histopathologic diagnosis by pre-evaluating the status of the WSIs. When the classifier was tested with completely different WSI dataset, the performance was not optimal because of the different tissue preparation quality. By including a small amount of data from the new dataset for training, the performance for the new dataset was much enhanced. These results indicated that WSI dataset should include tissues prepared from many different preparation conditions to construct a generalized tissue classifier. Thus, multi-national/multi-center dataset should be built for the application of deep learning in the real world medical practice.

Prediction of Chronic Disease-Related Inpatient Prolonged Length of Stay Using Machine Learning Algorithms / 대한의료정보학회지

Prediction of Drug–Drug Interactions by Using Profile Fingerprint Vectors and Protein Similarities / 대한의료정보학회지

Association between Full Electronic Medical Record System Adoption and Drug Use: Antibiotics and Polypharmacy / 대한의료정보학회지

Development and Validation of a Deep Learning System for Segmentation of Abdominal Muscle and Fat on Computed Tomography

Concordance of Three International Guidelines for Thyroid Nodules Classified by Ultrasonography and Diagnostic Performance of Biopsy Criteria

Clinical Usefulness of ¹⁸F-FC119S Positron-Emission Tomography as an Auxiliary Diagnostic Method for Dementia: An Open-Label, Single-Dose, Evaluator-Blind Clinical Trial

Pathologic discrepancies between colposcopy-directed biopsy and loop electrosurgical excision procedure of the uterine cervix in women with cytologic high-grade squamous intraepithelial lesions / 부인종양

OBJECTIVE: To investigate pathologic discrepancies between colposcopy-directed biopsy (CDB) of the cervix and loop electrosurgical excision procedure (LEEP) in women with cytologic high-grade squamous intraepithelial lesions (HSILs).METHODS: We retrospectively identified 297 patients who underwent both CDB and LEEP for HSILs in cervical cytology between 2015 and 2018, and compared their pathologic results. Considering the LEEP to be the gold standard, we evaluated the diagnostic performance of CDB for identifying cervical intraepithelial neoplasia (CIN) grades 2 and 3, adenocarcinoma in situ, and cancer (HSIL+). We also performed age subgroup analyses.RESULTS: Among the study population, 90.9% (270/297) had pathologic HSIL+ using the LEEP. The diagnostic performance of CDB for identifying HSIL+ was as follows: sensitivity, 87.8%; specificity, 59.3%; balanced accuracy, 73.6%; positive predictive value, 95.6%; and negative predictive value, 32.7%. Thirty-three false negative cases of CDB included CIN2,3 (n=29) and cervical cancer (n=4). The pathologic HSIL+ rate in patients with HSIL− by CDB was 67.3% (33/49). CDB exhibited a significant difference in the diagnosis of HSIL+ compared to LEEP in all patients (p<0.001). In age subgroup analyses, age groups <35 years and 35–50 years showed good agreement with the entire data set (p=0.496 and p=0.406, respectively), while age group ≥50 years did not (p=0.036).CONCLUSION: A significant pathologic discrepancy was observed between CDB and LEEP results in women with cytologic HSILs. The diagnostic inaccuracy of CDB increased in those ≥50 years of age.

Identification of Molecular Signatures in Mild Intrinsic Atopic Dermatitis by Bioinformatics Analysis

BACKGROUND: Atopic dermatitis (AD) is recognized as a common inflammatory skin disease and frequently occurred in Asian and Black individuals.OBJECTIVE: Since the limitation of dataset associated with human severe AD, this study aimed to screen potential novel biomarkers involved in mild AD.METHODS: Expression profile data (GSE75890) were obtained from the database of Gene Expression Omnibus. Using limma package, the differentially expressed genes (DEGs) between samples from AD and healthy control were selected. Furthermore, function analysis was conducted. Meanwhile, the protein-protein interaction (PPI) network and transcription factor (TF)-miRNA-target regulatory network were constructed. And quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the expressions patterns of key genes.RESULTS: In total, 285 DEGs including 214 upregulated and 71 downregulated genes were identified between samples from two groups. The upregulated DEGs were mainly involved in nine pathways, such as hematopoietic cell lineage, pertussis, p53 signaling pathway, staphylococcus aureus infection, and cell cycle, while tight junction was the only pathway enriched by the downregulated DEGs. Cyclin B (CCNB)1, CCNB2, cyclin A (CCNA)2, C-X-C motif chemokine ligand (CXCL)10, and CXCL9 were key nodes in PPI network. The TF-miRNA-target gene regulatory network focused on miRNAs such as miR-106b, miR-106a, and miR-17, TFs such as nuclear factor kappa B subunit 1, RELA proto-oncogene, Sp1 transcription factor, and genes such as matrix metallopeptidase 9, peroxisome proliferator activated receptor gamma , and serpin family E member 1. Moreover, the upregulation of these genes, including CCNB1, CCNB2, CCNA2, CXCL10, and CXCL9 were confirmed by qRT-PCR.CONCLUSION: CCNB1, CCNB2, CCNA2, and CXCL9 might be novel markers of mild AD. miR-106b and miR-17 may involve in regulation of immune response in AD patients.

mTOR-coordinated Post-Transcriptional Gene Regulations: from Fundamental to Pathogenic Insights

Post-transcriptional regulations of mRNA transcripts such as alternative splicing and alternative polyadenylation can affect the expression of genes without changing the transcript levels. Recent studies have demonstrated that these post-transcriptional events can have significant physiological impacts on various biological systems and play important roles in the pathogenesis of a number of diseases, including cancers. Nevertheless, how cellular signaling pathways control these post-transcriptional processes in cells are not very well explored in the field yet. The mammalian target of rapamycin complex 1 (mTORC1) pathway plays a key role in sensing cellular nutrient and energy status and regulating the proliferation and growth of cells by controlling various anabolic and catabolic processes. Dysregulation of mTORC1 pathway can tip the metabolic balance of cells and is associated with a number of pathological conditions, including various types of cancers, diabetes, and cardiovascular diseases. Numerous reports have shown that mTORC1 controls its downstream pathways through translational and/or transcriptional regulation of the expression of key downstream effectors. And, recent studies have also shown that mTORC1 can control downstream pathways via post-transcriptional regulations. In this review, we will discuss the roles of post-transcriptional processes in gene expression regulations and how mTORC1-mediated post-transcriptional regulations contribute to cellular physiological changes. We highlight post-transcriptional regulation as an additional layer of gene expression control by mTORC1 to steer cellular biology. These emphasize the importance of studying post-transcriptional events in transcriptome datasets for gaining a fuller understanding of gene expression regulations in the biological systems of interest.

Основные показатели здоровья: В центре внимания: Повестка дня в области устойчивого развития на период до 2030 года

Основные показатели здоровья представляют собой важные количественные критерии, позволяющие отслеживать прогресс в достижении целевых ориентиров в области здоровья и благополучия в 53 государствах-членах Европейского региона ВОЗ. В этом году они выступают в качестве ориентиров для Тринадцатой общей программы работы на 2019–2023 гг. (ОПР-13) и Европейской программы работы (ЕПР). Оба вышеуказанных рамочных документа содержат общие глобальные приоритеты, причем ЕПР адаптирует их к региональному контексту, подчеркивая масштабы и многообразие вопросов и задач общественного здравоохранения в Регионе.

Core health indicators in the WHO European Region: special focus: 2030 Sustainable Development Agenda

Core health indicators provide valuable measurements for monitoring progress towards the achievement of health and well-being targets in the 53 Member States of the WHO European Region. This year, they serve as a baseline for WHO’s Thirteenth General Programme of Work, 2019–2023 (GPW13) and European Programme of Work (EPW). Both frameworks present shared global priorities; the EPW takes those priorities and adapts them to the regional context, emphasizing the magnitude and diversity of public health issues and challenges in our Region.