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1.
BMC Gastroenterol ; 24(1): 127, 2024 Apr 04.
Artigo em Inglês | MEDLINE | ID: mdl-38575859

RESUMO

BACKGROUND/AIM: London Protocol (LP) and Classification allied to high-resolution manometry (HRM) technological evolution has updated and enhanced the diagnostic armamentarium in anorectal disorders. This study aims to evaluate LP reproducibility under water-perfused HRM, provide normal data and new parameters based on 3D and healthy comparison studies under perfusional HRM. METHODS: Fifty healthy (25 F) underwent water-perfused 36 channel HRM based on LP at resting, squeeze, cough, push, and rectal sensory. Additional 3D manometric parameters were: pressure-volume (PV) 104mmHg2.cm (resting, short and long squeeze, cough); highest and lowest pressure asymmetry (resting, short squeeze, and cough). Complementary parameters (CP) were: resting (mean pressure, functional anal canal length); short squeeze (mean and maximum absolute squeeze pressure), endurance (fatigue rate, fatigue rate index, capacity to sustain); cough (anorectal gradient pressure); push (rectum-anal gradient pressure, anal canal relaxation percent); recto-anal inhibitory reflex (anal canal relaxation percent). RESULTS: No difference to genders: resting (LP, CP, and 3D); short squeeze (highest pressure asymmetry); endurance (CP); cough (CP, highest and lowest pressure asymmetry); push (gradient pressure); rectal sensory. Higher pressure in men: short squeeze (maximum incremental, absolute, and mean pressure, PV, lowest pressure asymmetry); long squeeze (PV); cough (anal canal and rectum maximum pressure, anal canal PV); push (anal canal and rectum maximum pressure). Anal canal relaxation was higher in women (push). CONCLUSIONS: LP reproducibility is feasible under water-perfused HRM, and comparative studies could bring similarity to dataset expansion. Novel 3D parameters need further studies with healthy and larger data to be validated and for disease comparisons. KEY POINTS: • London Protocol and Classification allied with the technological evolution of HRM (software and probes) has refined the diagnostic armamentarium in anorectal disorders. • Novel 3D and deepening the analysis of manometric parameters before the London Classification as a contributory diagnostic tool. • Comparison of healthy volunteers according to the London Protocol under a perfusional high-resolution system could establish equivalence points.


Assuntos
Incontinência Fecal , Doenças Retais , Humanos , Feminino , Masculino , Pressão , Reprodutibilidade dos Testes , Londres , Doenças Retais/diagnóstico , Manometria/métodos , Reto , Canal Anal , Tosse
2.
Br J Sports Med ; 58(15): 852-859, 2024 Jul 25.
Artigo em Inglês | MEDLINE | ID: mdl-38286574

RESUMO

OBJECTIVES: The relationship between sport-related injuries and Para athlete impairment type has not yet been comprehensively studied. This study aimed to describe injury incidence according to athlete impairment type during the London 2012 and Rio 2016 Summer Paralympic Games, by sex, age, Games period, chronicity and anatomical area. METHODS: A combined analysis of 7222 athletes was conducted comprising 101 108 athlete days, using pooled data. Internet sources were used to identify impairments of registered athletes. Impairment types: brain disorders (BD), limb deficiency, neuromuscular disorders (NMD), spinal cord-related disorders, visual impairment (VI) and 'all others' (OTH: impaired passive range of movement, intellectual impairment, leg length difference, short stature and unknown impairments). Results by impairment type are reported as univariate unadjusted incidences (injuries/1000 athlete days; 95% CIs). Statistical significance between impairment types was determined when 95% CIs did not overlap. RESULTS: The overall crude unadjusted incidence of injury was 11.1 (95% CI 10.4 to 11.9), significantly higher in VI (13.7 (95% CI 11.0 to 15.7)) and NMD (13.3 (95% CI 11.1 to 16.1)) compared with BD (9.1 (95% CI 7.7 to 10.8)). Acute (sudden onset) (8.6 (95% CI 7.3 to 10.1)) and lower limb (6.6 (95% CI 5.4 to 8.1)) injuries were higher among athletes with VI, while athletes with NMD had a higher incidence of repetitive (gradual onset) (5.9 (95% CI 4.3 to 8.0)) and upper limb (6.9 (95% CI 5.2 to 9.0)) injuries compared with other impairments. CONCLUSIONS: Incidence and type of injuries differed between athlete impairment types. Athletes with VI or NMD sustained the highest incidence of injury, and athletes with BD had the lowest. Findings of this study can inform the management of competition-related injuries in Para athletes.


Assuntos
Traumatismos em Atletas , Paratletas , Esportes para Pessoas com Deficiência , Humanos , Incidência , Traumatismos em Atletas/epidemiologia , Masculino , Feminino , Adulto , Adulto Jovem , Adolescente , Londres/epidemiologia , Pessoa de Meia-Idade , Brasil/epidemiologia , Criança
3.
J Asthma ; 61(1): 1-9, 2024 01.
Artigo em Inglês | MEDLINE | ID: mdl-37417908

RESUMO

INTRODUCTION: Dyspnea during activities of daily living (ADL) is frequently reported by adults with asthma. However, instruments that specifically assess that in people with asthma have not yet been validated. OBJECTIVES: To investigate the validity and reliability, including standard error of measurement (SEM) and Minimum Detectable Change (MDC), of the London Chest Activity of Daily Living (LCADL) scale for adults with asthma. METHODS: Adults with asthma answered the LCADL scale which was performed twice by the same rater. Spirometry, 6-min walk test (6MWT), St George's Respiratory Questionnaire (SGRQ), modified Medical Research Council (mMRC) dyspnea scale, Asthma Quality of Life questionnaire (AQLQ), Asthma Control Test (ACT), and Glittre-ADL test were assessed. For statistical analyses, Spearman correlation, Wilcoxon test, Intraclass Correlation Coefficient (ICC), Cronbach's alpha coefficient, SEM, MDC were performed. RESULTS: Seventy participants were included (30% men, 44 ± 15 years old, BMI 27[23-31]kg/m2, FEV1 80 ± 17%predicted). For convergent validity, the LCADL scale was moderately correlated with SGRQ, AQLQ, and Glittre-ADL (r = 0.57, -0.46, and 0.41 respectively; p < 0.0001). The LCADL scale correlated weakly with the mMRC scale, ACT, and spirometry measures (-0.23

Assuntos
Asma , Doença Pulmonar Obstrutiva Crônica , Masculino , Adulto , Humanos , Pessoa de Meia-Idade , Feminino , Asma/diagnóstico , Atividades Cotidianas , Qualidade de Vida , Reprodutibilidade dos Testes , Londres , Dispneia/diagnóstico , Dispneia/etiologia , Inquéritos e Questionários
4.
Hist Psychiatry ; 34(3): 287-304, 2023 09.
Artigo em Inglês | MEDLINE | ID: mdl-37272412

RESUMO

The Society for Psychical Research (SPR) of London was founded in 1882 with the purpose of investigating psychical phenomena, especially the theme of survival, with scientific rigour. Despite the recognized importance of the SPR for dynamic psychiatry in the nineteenth and twentieth centuries, there are few studies of its epistemological contributions to the theme of survival and its implications to science. In order to fill this gap, we have consulted the main journals of the SPR in its golden period, and highlight the epistemologies of Sidgwick, Myers, James, Podmore, Schiller, Lodge and Richet. We conclude that the authors, whether for or against survival, argued in defence of an expanded science, and looked forward to understanding the complexity of human experience.


Assuntos
Parapsicologia , Psiquiatria , Humanos , Parapsicologia/história , Estado de Consciência , Psiquiatria/história , Londres
5.
Zootaxa ; 5232(1): 1-105, 2023 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-37045117

RESUMO

We present an annotated and illustrated type catalogue of the predacious shieldbugs (Hemiptera: Heteroptera: Pentatomidae: Asopinae), housed in the collection of the Natural History Museum, London. This work involves recognising types and their status, recording their label data and providing images of both the types and their labels. Although we personally refrain from designating lectotypes as the International Code of Zoological Nomenclature recommends that it should be done "as part of a revisionary or other taxonomic work" (ICZN 1999: Recommendation 74G), we have nevertheless accepted that lectotypes were designated before 2000 (see ICZN 1999: Art. 74 §§ 5 and 6), for the following 43 species: by Distant (1880) for Apateticus halys Dallas, Arma fuscescens Dallas, Arma modesta Dallas, Arma tincta Dallas, Oplomus rutilus Dallas, Oplomus ventralis Dallas, Stiretrus ornatus Dallas, Stiretrus ruficeps Dallas; by Synave (1969) for Mecosoma floridum Distant and Podisus volxemi Distant; by Thomas (1992) for Arma ampla Walker, Arma grandis Dallas, Arma lateralis Walker, Arma nigrispina Dallas, Arma obscura Dallas, Mormidea semialba Walker, Oplomus equestris Distant, Oplomus festivus Dallas, Oplomus nigripennis Dallas, Oplomus pulcher Dallas, Oplomus stellatus Distant, Oplomus violaceus Dallas, Platynopus conspersus Walker, Podisus amulae Distant, Podisus falcatus Distant, Podisus gaumeri Distant, Podisus insignis Distant, Podisus nigriventris Distant, Podisus sculptus Distant, Podisus smithi Distant, Stiretrus annulatus Distant, Stiretrus caeruleus Dallas, Supputius typicus Distant, Tynacantha marginata Dallas, Tynacantha splendens Distant, Zicrona cuprea Dallas and Zicrona marginella Dallas; and by Thomas (1994) for Anasida funebris Distant, Damarius bicolor Distant, Neoglypsus opulentus Distant, Neoglypsus viridicatus Distant, Incitatus primus Distant, and Jalloides versicolor Distant. We have also found out that Synave (1969) had designated the lectotype of Glypsus erubescens Distant before Linnavuori (1975). A syntype of Oplomus distinctus Distant, 1880 is located and Thomas's (1992: 57) synonymy of this species with O. catena (Drury, 1782) is confirmed. Informations regarding labels used by the first five curators of Hemiptera at the Natural History Museum, London (Adam White, William S. Dallas, Francis Walker, William L. Distant and William E. China) are provided. In total, we list herein 248 specimens examined in NHMUK (49 holotypes, 41 lectotypes, 84 syntypes, 17 paratypes, 25 paralectotypes, and 32 non-types which are historical specimens), representing 149 nominal species or 104 currently valid species (ca. 34% of the just over 300 valid Asopinae species worldwide).


Assuntos
Hemípteros , Heterópteros , Animais , Museus , Londres , História Natural
6.
Forensic Sci Int ; 342: 111532, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36462471

RESUMO

Age estimation is a fundamental competence of Forensic Anthropologists and Odontologists. The London Atlas is a dental development chart by AlQahtani et al. (2010) that gained recent notoriety due to its applicability in forensic scenarios. This study aimed to answer, by a systematic review of literature and meta-analysis, the following question: "on average, what is the deviation between real and estimated ages, when applying the London Atlas method in sub-adults?". This study was carried out according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered in the International Prospective Register of Systematic Reviews (PROSPERO). Five electronic databases were screened (PubMed, SciELO, Scopus, Web of Science, and LILACS), and active search was carried out. The quality assessment was performed by means of Joanna Briggs Institute Critical Appraisal Tools for Systematic Reviews. The initial search resulted in 1021 studies, from which 24 filled the inclusion criteria. For the meta-analysis, 17 studies provided sufficient data. Out of these, eleven studies enabled meta-analysis of mean absolute difference values. Standardized mean differences were 0.02 years for MD and 0.78 for MAD. Analysis of subgroups was also accomplished by sex, and did not indicated heterogeneity between males and females. The London Atlas is an accurate age estimation method, presenting acceptable error and bias values worldwide. Despite the high heterogeneity of the studies, majority of studies presented a low risk of bias. Meta-analysis showed a non-significant and slight tendency of overestimating age, in total. Sub-group analysis showed modestly better results for boys than girls.


Assuntos
Odontologia Legal , Feminino , Humanos , Masculino , Londres
7.
Braz J Cardiovasc Surg ; 37(Spec 1): 1-6, 2022 09 02.
Artigo em Inglês | MEDLINE | ID: mdl-36053997

RESUMO

In this review, I summarise the circumstances leading to the collaboration between London and Örebro on the basic research performed to study potential mechanisms underlying the improved patency of saphenous veins harvested by the no-touch technique. Histological studies reveal various forms of vascular damage to saphenous vein grafts harvested in conventional coronary artery bypass grafting (CABG) whereas no-touch grafts retain a normal architecture. The perivascular fat that remains intact on no-touch saphenous vein grafts seems to play a particularly important role as the "protector" of all layers of the graft. In addition, the perivascular fat is a source of adipose cell-derived factors that may contribute to the success of the no-touch technique. While a number of trials have compared no-touch with conventional grafts following CABG, these have generally been limited to short follow-up periods, low patient numbers, and inadequate histological data. When handling no-touch saphenous vein at harvesting, there is no direct contact of the vein by surgical instruments, spasm does not occur, and high-pressure intraluminal distension is not required. While damage to both endothelial and vascular smooth muscle cells are evident at the microscopic and ultrastructural level in conventional saphenous vein grafts, their structure in no-touch grafts is preserved. Also, in no-touch veins, the vasa vasorum remains intact and transmural blood supply is maintained. This microvascular network is disrupted during conventional harvesting, a situation likely to stimulate processes involved in graft occlusion. The use of excess graft material for histology is to be encouraged for the assessment of vascular damage and even surgeon competence. If you don't look, you don't find.


Assuntos
Ponte de Artéria Coronária , Veia Safena , Ponte de Artéria Coronária/métodos , Humanos , Londres , Veia Safena/transplante , Vasa Vasorum , Grau de Desobstrução Vascular/fisiologia
8.
J Membr Biol ; 255(4-5): 563-574, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-35534578

RESUMO

Erwin London dedicated considerable effort to understanding lipid interactions with membrane-resident proteins and how these interactions shaped the formation and maintenance of lipid phases and domains. In this endeavor, he developed ad hoc techniques that greatly contributed to advancements in the field. We have employed and/or modified/extended some of his methodological approaches and applied them to investigate lipid interaction with the nicotinic acetylcholine receptor (nAChR) protein, the paradigm member of the superfamily of rapid pentameric ligand-gated ion channels (pLGIC). Our experimental systems ranged from purified receptor protein reconstituted into synthetic lipid membranes having known effects on receptor function, to cellular systems subjected to modification of their lipid content, e.g., varying cholesterol levels. We have often employed fluorescence techniques, including fluorescence quenching of diphenylhexatriene (DPH) extrinsic fluorescence and of nAChR intrinsic fluorescence by nitroxide spin-labeled phospholipids, DPH anisotropy, excimer formation of pyrene-phosphatidylcholine, and Förster resonance energy transfer (FRET) from the protein moiety to the extrinsic probes Laurdan, DPH, or pyrene-phospholipid to characterize various biophysical properties of lipid-receptor interactions. Some of these strategies are revisited in this review. Special attention is devoted to the anionic phospholipid phosphatidic acid (PA), which stabilizes the functional resting form of the nAChR. The receptor protein was shown to organize its PA-containing immediate microenvironment into microdomains with high lateral packing density and rigidity. PA and cholesterol appear to compete for the same binding sites on the nAChR protein.


Assuntos
Canais Iônicos de Abertura Ativada por Ligante , Receptores Nicotínicos , Animais , Receptores Nicotínicos/química , Torpedo/metabolismo , Difenilexatrieno , Londres , Fosfatidilcolinas/metabolismo , Colesterol/química , Ácidos Fosfatídicos/metabolismo , Pirenos
9.
Child Neuropsychol ; 28(5): 597-626, 2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-34779691

RESUMO

Contemporary evidence shows that different intervention approaches can be effective in improving executive cognitive performance in preschoolers from poor homes. However, several aspects about the role of individual and contextual differences in intervention effects remain to be elucidated. The present study aimed to explore the impact of a computerized executive cognitive intervention with lab-based tasks in preschoolers from Unsatisfied Basic Needs (UBN) homes. In the context of a randomized controlled design, different activities were administered to children according to their baseline performance in a variety of cognitive tasks tapping inhibitory control, working memory, and planning demands (i.e., high- and low-performance intervention and control groups). Results suggested that the impact of the intervention was shown preferentially by high-performers in Tower of London and K-Bit tasks, who increased their performances in the posttest assessment. This finding supports the importance of considering individual and contextual differences in the design of interventions aimed at changing the cognitive performance of children from poor homes.


Assuntos
Memória de Curto Prazo , Resolução de Problemas , Criança , Cognição , Função Executiva , Humanos , Londres
10.
Cladistics ; 37(5): 559-570, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34570939

RESUMO

We analyzed 769 242 occurrence records for 115 424 species of terrestrial arthropods, from three biodiversity repositories (Global Biodiversity Information Facility (GBIF), Natural History Museum, London, and "Sistema de Informação Distribuído para Coleções Biológicas" (SpeciesLink)), to test the use of global-scale data points for quantitative assessments of areas of endemism. The data include Insecta (105,941 species), Arachnida (7984 species), Myriapoda (1229) and terrestrial crustaceans (270 Branchiopoda). The species were assigned to 14 543 higher taxonomic groups because such groups often characterize larger areas of endemism. Putative areas of endemism were visualized as sets of cells displaying unique groups of species without the assumption of hierarchical relationships. Yet, the use of 10° grid cells recovered many large areas broadly corresponding to biogeographic Regions (Nearctic, Neotropical, Panamanian, Palaearctic, Afrotropical, Australian, Oceanian and Oriental) albeit with the limits poorly defined. An analysis of 5° grids resulted in 306 sets included in the different biogeographic Realms: Afrotropical, Australian, Madagascan, Nearctic, Neotropical, Oceanian, Oriental, Palaearctic, Saharo-Arabian and Sino-Japanese. The Panamanian Realm comprises 89 partly overlapping sets, crossing the Nearctic and Neotropical boundaries. A total of 7338 species of Insecta were endemic to some areas (Sino-Japanese, Afrotropical, Panamanian, Palaearctic, among others), followed by Arachnida (412 spp) and 105 species in other clades ranked as "classes". Six sets were supported only by genera, except for Panamanian sets that were supported by genera and families. Many of the species in the dataset are included in IUCN red lists, but probably most of those have distributions more restricted than global areas of endemism; only 102 appear as endemic to some area (Neartic, Madagascan, Panamanian, Afrotropical, among others). The results show that data from global databases can be used to identify areas of endemism on a worldwide basis but-owing to their incompleteness-only at a relatively coarse level. At the level of resolution currently allowed by such databases, such global studies are only complementary to studies where areas are determined subjectively by systematists (instead of actual point records), or studies using point records in datasets for specific taxonomic groups curated and compiled by specialists.


Assuntos
Artrópodes , Biodiversidade , Animais , Aracnídeos , Artrópodes/classificação , Geografia , Insetos/classificação , Londres
11.
Environ Pollut ; 285: 117664, 2021 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-34380230

RESUMO

The impacts of COVID-19 lockdown restrictions have provided a valuable global experiment into the extent of improvements in air quality possible with reductions in vehicle movements. Mexico City, London and Delhi all share the problem of air quality failing WHO guideline limits, each with unique situations and influencing factors. We determine, discuss and compare the air quality changes across these cities during the COVID-19, to understand how the findings may support future improvements in their air quality and associated health of citizens. We analysed ground-level PM10, PM2.5, NO2, O3 and CO changes in each city for the period 1st January to August 31, 2020 under different phases of lockdown, with respect to daily average concentrations over the same period for 2017 to 2019. We found major reductions in PM10, PM2.5, NO2 and CO across the three cities for the lockdown phases and increases in O3 in London and Mexico City but not Delhi. The differences were due to the O3 production criteria across the cities, for Delhi production depends on the VOC-limited photochemical regime. Levels of reductions were commensurate with the degree of lockdown. In Mexico City, the greatest reduction in measured concentration was in CO in the initial lockdown phase (40%), in London the greatest decrease was for NO2 in the later part of the lockdown (49%), and in Delhi the greatest decrease was in PM10, and PM2.5 in the initial lockdown phase (61% and 50%, respectively). Reduction in pollutant concentrations agreed with reductions in vehicle movements. In the initial lockdown phase vehicle movements reduced by up to 59% in Mexico City and 63% in London. The cities demonstrated a range of air quality changes in their differing geographical areas and land use types. Local meteorology and pollution events, such as forest fires, also impacted the results.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , COVID-19 , Poluentes Atmosféricos/análise , Poluição do Ar/análise , Cidades , Controle de Doenças Transmissíveis , Monitoramento Ambiental , Humanos , Índia , Londres , México , Pandemias , Material Particulado/análise , SARS-CoV-2
12.
Artigo em Inglês | MEDLINE | ID: mdl-34072367

RESUMO

The basis for achieving success in sport is technical preparation supported by adequate level of physical fitness. During judo competitions, athletes use technique to meet tactical objectives aimed to achieve victory. The modification of the rules of combat in judo that has been carried out in recent years has changed the course of competition. It seems to be interesting if there are relations between technical and tactical preparation expressed by means of indices and modification of the course of the fight caused by changes in the rules. The purpose of the paper was to determine the values of technical and tactical preparation of judokas during competition at the elite level. A hundred and twenty bouts during the Olympic Games in London in 2012 as well as 136 bouts fought during the World Championships in Rio de Janeiro in 2013 were analyzed. Verification was performed by calculating indicators of technical and tactical preparation. The results show a significant correlation between the indicators of technical and tactical preparation and the ranking in the general classification of the analyzed competitions. There were no statistically significant correlations between the change of fighting rules and the level of the examined indices of technical and tactical preparation. The results of the study verified the appropriate method of preparation for the competitions analyzed.


Assuntos
Desempenho Atlético , Artes Marciais , Atletas , Brasil , Humanos , Londres
13.
Br J Sports Med ; 55(23): 1342-1349, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34039584

RESUMO

OBJECTIVE: To describe the implementation of a health monitoring programme for Norwegian Paralympic and Olympic candidates over five consecutive Olympic and Paralympic Games cycles (London 2012, Sochi 2014, Rio de Janeiro 2016, PyeongChang 2018 and Tokyo 2020). METHODS: Athletes were monitored for 12-18 months preparing for the games using a weekly online questionnaire (OSTRC-H2) with follow-up by physicians and physiotherapists, who provided clinical care and classified reported problems. RESULTS: Between 2011 and 2020, 533 Olympic and 95 Paralympic athletes were included in the monitoring programme, with an overall response of 79% to the weekly questionnaire and a total observation period of 30 826 athlete weeks. During this time, 3770 health problems were reported, with a diagnosis rate of 97%. The average prevalence of health problems at any given time was 32% among Olympic athletes and 37% among Paralympic athletes. Acute traumatic injuries represented the greatest burden for Olympic team sport athletes, and illnesses represented the greatest burden for Olympic endurance and Paralympic athletes. On average, Olympic athletes lost 27 days and Paralympic athletes lost 33 days of training per year due to health problems. CONCLUSION: Conducting long-term health monitoring of Olympic and Paralympic athletes is challenging, particularly because athletes travel frequently and often relate to many medical providers. This programme has been implemented and improved within Team Norway for five Olympic and Paralympic cycles and during this time we believe it has helped protect our athletes' health.


Assuntos
Traumatismos em Atletas , Paratletas , Atletas , Traumatismos em Atletas/epidemiologia , Traumatismos em Atletas/prevenção & controle , Brasil , Humanos , Londres , Tóquio
14.
BMJ Open ; 11(5): e045609, 2021 05 13.
Artigo em Inglês | MEDLINE | ID: mdl-33986056

RESUMO

BACKGROUND: Preventing infantile anaemia and ensuring optimal growth and development during early childhood, particularly in resource-constrained settings, represent an ongoing public health challenge. Current responses are aligned to treatment-based solutions, instead of determining the roles of its inter-related causes. This project aims to assess and understand the complex interplay of eco-bio-social-political factors that determine infantile anaemia to inform policy, research design and prevention practices. METHODS: This is a longitudinal birth cohort study including four components: (1) biological, will assess known blood markers of iron homeostasis and anaemia and stool microbiota to identify and genetically analyse the participants' flora; (2) ecological, will assess and map pollutants in air, water and soil and evaluate features of nutrition and perceived food security; (3) social, which will use different qualitative research methodologies to explore key stakeholders and informants' perceptions related to nutritional, environmental and anaemia topics, participant observations and a participatory approach and (4) a political analysis, to identify and assess the impact of policies, guidelines and programmes at all levels for infantile anaemia in the three regions. Finally, we will also explore the role of social determinants and demographic variables longitudinally for all study participants. This project aims to contribute to the evidence of the inter-related causal factors of infantile anaemia, addressing the complexity of influencing factors from diverse methodological angles. We will assess infantile anaemia in three regions of Peru, including newborns and their mothers as participants, from childbirth until their first year of age. ETHICS AND DISSEMINATION: Ethical approval was obtained from the Institutional Research Ethics Committee of the Instituto Nacional de Salud del Niño (Lima, Peru), CIEI-043-2019. An additional opinion has been granted by the Ethical Committee of Queen Mary University of London (London, UK). Dissemination across stakeholders is taking part as a continues part of the research process.


Assuntos
Anemia , Anemia/epidemiologia , Pré-Escolar , Estudos de Coortes , Feminino , Crescimento e Desenvolvimento , Homeostase , Humanos , Lactente , Recém-Nascido , Ferro , Londres , Peru
15.
Zootaxa ; 4964(3): zootaxa.4964.3.2, 2021 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-33903504

RESUMO

The type specimens of the New World Stigmoderini deposited in the Natural History Museum in London are catalogued and illustrated. Twenty-eight lectotypes are designated, one of which is a new lectotype, since the previous one is considered invalid under the article 74.2. (ICZN 1999). Holotype and in some cases, paratypes, are recognized for the following taxa: Conognatha nanula Hoscheck, 1934, Conognatha blairi Hoscheck, 1934, Hiperantha decorata var. insignata Hoscheck, 1928 and Hiperantha saundersi Théry, 1928. In addition, Lasionota oberthuri (Kerremans, 1897) rev. stat. is reinstated as a valid species, having been considered to be a junior synonym of Lasionota tetrazonus (Chevrolat, 1838) since 1997. The comparison of the reinstated species, with the recently described species Lasionota inca Moore Diéguez, 2019 showed that both are conspecific and hence L. inca syn. nov. is proposed as a junior synonym of L. oberthuri.


Assuntos
Besouros/química , Museus , Distribuição Animal , Animais , Besouros/fisiologia , Londres , Museus/estatística & dados numéricos
16.
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; Braz. J. Psychiatry (São Paulo, 1999, Impr.);43(2): 131-137, Mar.-Apr. 2021. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1285522

RESUMO

Objectives: A previous study has shown that schizophrenia (SCZ) is accompanied by lowered levels of trace/metal elements, including cesium. However, it is not clear whether changes in cesium, rubidium, and rhenium are associated with activated immune-inflammatory pathways, cognitive impairments, and the symptomatology of SCZ. Methods: This study measured cesium, rubidium, and rhenium, cognitive impairments (using the Brief Assessment of Cognition in Schizophrenia [BACS]), and the levels of cytokines/chemokines interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and eotaxin (CCL11) in 120 patients with SCZ and 54 healthy controls. Severity of illness was assessed using the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Negative Symptoms (SANS), the Fibromyalgia and Chronic Fatigue Syndrome Rating (FF) Scale, and the Hamilton Depression Rating Scale (HAM-D). Results: Serum cesium was significantly lower in patients with SCZ as compared with controls. Further, serum cesium was significantly and inversely associated with CCL11 and TNF-α, but not IL-1β, in patients with SCZ; significant inverse associations were also noted between serum cesium levels and BPRS, FF, HAM-D, and SANS scores. Finally, cesium was positively correlated with neurocognitive probe results including the Tower of London, Symbol Coding, Controlled Word Association, Category Instances, Digit Sequencing Task, and List Learning tests. Conclusion: The results suggest that lowered serum cesium levels may play a role in the pathophysiology of SCZ, contributing to specific symptom domains including negative, depressive and fatigue symptoms, neurocognitive impairments (spatial working, episodic, and semantic memory and executive functions), and neuroimmune pathways.


Assuntos
Humanos , Esquizofrenia , Disfunção Cognitiva , Psicologia do Esquizofrênico , Biomarcadores , Césio , Londres
17.
PLoS One ; 16(2): e0244478, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33566815

RESUMO

The estimation of the vertical components of built-up areas from free Digital Elevation Model (DEM) global data filtered by multi-scale convolutional, morphological and textural transforms are generalized at the spatial resolution of 250 meters using linear least-squares regression techniques. Six test cases were selected: Hong Kong, London, New York, San Francisco, Sao Paulo, and Toronto. Five global DEM and two DEM composites are evaluated in terms of 60 combinations of linear, morphological and textural filtering and different generalization techniques. Four generalized vertical components estimates of built-up areas are introduced: the Average Gross Building Height (AGBH), the Average Net Building Height (ANBH), the Standard Deviation of Gross Building Height (SGBH), and the Standard Deviation of Net Building Height (SNBH). The study shows that the best estimation of the net GVC of built-up areas given by the ANBH and SNBH, always contains a greater error than their corresponding gross GVC estimation given by the AGBH and SGBH, both in terms of mean and standard deviation. Among the sources evaluated in this study, the best DEM source for estimating the GVC of built-up areas with univariate linear regression techniques is a composite of the 1-arcsec Shuttle Radar Topography Mission (SRTM30) and the Advanced Land Observing Satellite (ALOS) World 3D-30 m (AW3D30) using the union operator (CMP_SRTM30-AW3D30_U). A multivariate linear model was developed using 16 satellite features extracted from the CMP_SRTM30-AW3D30_U enriched by other land cover sources, to estimate the gross GVC. A RMSE of 2.40 m and 3.25 m was obtained for the AGBH and the SGBH, respectively. A similar multivariate linear model was developed to estimate the net GVC. A RMSE of 6.63 m and 4.38 m was obtained for the ANBH and the SNBH, respectively. The main limiting factors on the use of the available global DEMs for estimating the GVC of built-up areas are two. First, the horizontal resolution of these sources (circa 30 and 90 meters) corresponds to a sampling size that is larger than the expected average horizontal size of built-up structures as detected from nadir-angle Earth Observation (EO) data, producing more reliable estimates for gross vertical components than for net vertical component of built-up areas. Second, post-production processing targeting Digital Terrain Model specifications may purposely filter out the information on the vertical component of built-up areas that are contained in the global DEMs. Under the limitations of the study presented here, these results show a potential for using global DEM sources in order to derive statistically generalized parameters describing the vertical characteristics of built-up areas, at the scale of 250x250 meters. However, estimates need to be evaluated in terms of the specific requirements of target applications such as spatial population modelling, urban morphology, climate studies and so on.


Assuntos
Monitoramento Ambiental/métodos , Mapeamento Geográfico , População Urbana/tendências , Brasil , Cidades/estatística & dados numéricos , Sistemas de Informação Geográfica/tendências , Hong Kong , Processamento de Imagem Assistida por Computador/métodos , Modelos Lineares , Londres , Modelos Teóricos , Análise Multivariada , Cidade de Nova Iorque , Radar , Análise de Regressão , São Francisco , Análise Espacial
18.
Braz J Psychiatry ; 43(2): 131-137, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-32556004

RESUMO

OBJECTIVES: A previous study has shown that schizophrenia (SCZ) is accompanied by lowered levels of trace/metal elements, including cesium. However, it is not clear whether changes in cesium, rubidium, and rhenium are associated with activated immune-inflammatory pathways, cognitive impairments, and the symptomatology of SCZ. METHODS: This study measured cesium, rubidium, and rhenium, cognitive impairments (using the Brief Assessment of Cognition in Schizophrenia [BACS]), and the levels of cytokines/chemokines interleukin (IL)-1ß, tumor necrosis factor (TNF)-α, and eotaxin (CCL11) in 120 patients with SCZ and 54 healthy controls. Severity of illness was assessed using the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Negative Symptoms (SANS), the Fibromyalgia and Chronic Fatigue Syndrome Rating (FF) Scale, and the Hamilton Depression Rating Scale (HAM-D). RESULTS: Serum cesium was significantly lower in patients with SCZ as compared with controls. Further, serum cesium was significantly and inversely associated with CCL11 and TNF-α, but not IL-1ß, in patients with SCZ; significant inverse associations were also noted between serum cesium levels and BPRS, FF, HAM-D, and SANS scores. Finally, cesium was positively correlated with neurocognitive probe results including the Tower of London, Symbol Coding, Controlled Word Association, Category Instances, Digit Sequencing Task, and List Learning tests. CONCLUSION: The results suggest that lowered serum cesium levels may play a role in the pathophysiology of SCZ, contributing to specific symptom domains including negative, depressive and fatigue symptoms, neurocognitive impairments (spatial working, episodic, and semantic memory and executive functions), and neuroimmune pathways.


Assuntos
Disfunção Cognitiva , Esquizofrenia , Biomarcadores , Césio , Humanos , Londres , Psicologia do Esquizofrênico
19.
Esc. Anna Nery Rev. Enferm ; 25(4): e20200152, 2021.
Artigo em Português | LILACS, BDENF - Enfermagem | ID: biblio-1286364

RESUMO

Resumo Objetivo refletir sobre a figura pública de Florence Nightingale, suas realizações, Reforma Sanitária e a criação da Escola de Enfermeiras, e compreender o nascimento da enfermagem como profissão. Método partiu-se da literatura de um quadro das pressões sociais que agiam sobre o comportamento individual de Florence Nightingale e dos marcos divisórios aparentes, que entendemos como a densidade das relações sócio-históricas, e o seu tempo social. Análise sócio-histórica da história de vida de Florence Nightingale e da literatura social de Charles Dickens. O marco temporal compreendeu da promulgação da New Poor Law (1.834) à revogação (1.601). Resultados Florence Nightingale foi uma mulher adiante do seu tempo que, contrariando as teorias do Darwinismo social de sua época, criou a profissão da enfermeira, e produziu uma clivagem na profissão definindo-a como ciência e arte. Conclusão e implicações para a enfermagem ao criar a figura emblemática da Dama da Lâmpada, Florence Nightingale gravou no cuidado de enfermagem, o zelo, o desvelo e a compaixão, aqui entendida como empatia e piedade com o sofrimento do outro acompanhada do desejo de minorá-lo, uma participação espiritual na dor do outro.


Resumen Objetivo reflexionar sobre la figura pública de Florence Nightingale, sus logros, Reforma Sanitaria y la creación de la Escuela de Enfermeras, y comprender el nacimiento de la enfermería como profesión. Método se partió de la literatura de un cuadro de las presiones sociales sobre el comportamiento individual de Florence Nightingale y de los marcos divisorios aparentes que se entiende como la densidad de las relaciones socio histórico y su tiempo social. Análisis socio histórico de la historia de vida de Florence Nightingale y de la literatura social de Charles Dickens. El marco temporal se comprendió entre la promulgación del New Poor Law en 1834 y su revocación promulgada en 1601. Resultados Florence Nightingale fue una mujer adelante a su tiempo que, contrariando las teorías del Darwinismo social de su época, creó la profesión de enfermera, y produjo una mirada embrionaria en la profesión definiéndola como ciencia y arte. Conclusión e implicaciones para la enfermería al crear la figura emblemática de la Dama de la Lámpara, Florence Nightingale registró en el cuidado de enfermería, el celo, el cuidado y la compasión, entendido aquí como empatía y piedad con el sufrimiento del otro acompañado del deseo de una disminución, una participación espiritual en el dolor del otro.


Abstract Objective to reflect on Florence Nightingale's public figure, her achievements, Health Care Reform and the creation of the School for Nurses, and understand the birth of nursing as a profession. Method a framework of the social pressures acting on Florence Nightingale's individual behavior and the apparent dividing marks, which we understand as the density of socio-historical relations, and her social time, was drawn from the literature. This is a socio-historical analysis of Florence Nightingale's life story and Charles Dickens' social literature. The time frame spanned from the enactment of the New Poor Law (1834) to the repeal (1601). Results Florence Nightingale was a woman ahead of her time who, going against the theories of social Darwinism of her time, created the nurse profession, and produced a divide in the profession by defining it as science and art. Conclusion and implications for nursing by creating the emblematic figure of the Lady of the Lamp, Florence Nightingale engraved in nursing care, zeal, devotion, and compassion, here understood as empathy and pity for the suffering of others accompanied by the desire to alleviate it, a spiritual participation in the pain of others.


Assuntos
Humanos , Feminino , História do Século XIX , Reforma dos Serviços de Saúde/história , Descoberta do Conhecimento/história , História da Enfermagem , Profissionais de Enfermagem/história , Pobreza/história , Condições Sociais/história , Identificação Social , Higiene/história , Agressão , Alcoolismo , Londres
20.
Zootaxa ; 4883(1): zootaxa.4883.1.1, 2020 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-33311297

RESUMO

The Natural History Museum, London, houses of one of the largest insect collections in the world including several hundred specimens of the small lacewing family Osmylidae. Herein we provide the complete label information, specimen condition, locality and habitus pictures of the Osmylidae primary types of the Natural History Museum, with some historical information about the specimens.


Assuntos
Holometábolos , Museus , Animais , Insetos , Londres , História Natural
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