RESUMO
Transthoracic echocardiography and cardiac magnetic resonance imaging revealed a well-defined globular mass attached to the anterolateral papillary muscle. The mass was hyperintense on T1 and T2 weighted images with suppression of signal on fat saturated and short tau inversion recovery (STIR) images. This imaging established the diagnosis of cardiac lipoma attached to the anterolateral papillary muscle, Papillary muscle is a very rare location of lipoma, which is rarely reported in the literature.
Assuntos
Neoplasias Cardíacas , Lipoma , Imageamento por Ressonância Magnética , Músculos Papilares , Humanos , Músculos Papilares/diagnóstico por imagem , Músculos Papilares/patologia , Músculos Papilares/cirurgia , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/cirurgia , Neoplasias Cardíacas/patologia , Lipoma/diagnóstico por imagem , Lipoma/cirurgia , Lipoma/patologia , Ecocardiografia , Masculino , Pessoa de Meia-Idade , Feminino , Valor Preditivo dos TestesAssuntos
Neoplasias Cardíacas , Rabdomioma , Esclerose Tuberosa , Humanos , Masculino , Neoplasias Cardíacas/diagnóstico por imagem , Estudos Longitudinais , Imageamento por Ressonância Magnética , Rabdomioma/diagnóstico por imagem , Esclerose Tuberosa/diagnóstico por imagem , Esclerose Tuberosa/complicações , Adulto JovemAssuntos
Cardiomiopatia Restritiva , Neoplasias Cardíacas , Hemangiossarcoma , Humanos , Hemangiossarcoma/patologia , Hemangiossarcoma/complicações , Hemangiossarcoma/diagnóstico , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/complicações , Neoplasias Cardíacas/diagnóstico por imagem , Cardiomiopatia Restritiva/patologia , Cardiomiopatia Restritiva/etiologia , Masculino , Pessoa de Meia-Idade , Feminino , Evolução FatalRESUMO
Primary cardiac angiosarcoma is a rare, aggressive malignancy that commonly metastasizes to various organs. The presenting symptoms are typically nonspecific, so a comprehensive examination is required to confirm the diagnosis promptly. This case report describes the presentation of an older patient with a history of neoplasms. Echocardiography and biopsy were performed, but despite surgical intervention to resect a large right atrial mass, the patient died. A final diagnosis of primary angiosarcoma was made based on the resected specimen.
Assuntos
Neoplasias Cardíacas , Hemangiossarcoma , Humanos , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas/cirurgia , Idoso , Hemangiossarcoma/diagnóstico , Hemangiossarcoma/cirurgia , Evolução Fatal , Biópsia , Masculino , Átrios do Coração/patologia , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/cirurgia , Ecocardiografia , Procedimentos Cirúrgicos Cardíacos/métodosRESUMO
The antemortem diagnosis of secondary cardiac involvement by lymphoma remains suboptimal. Prognosis is worse with delayed diagnosis as the tumor burden increases with the multicompartment participation. Chemotherapy may improve survival, but there is a risk of mortality due to treatment-related complications, such as myocardial rupture and fatal arrhythmias. Modified chemotherapy regimens may prevent such complications, but the data are limited. We report the case of a 72-year-old woman diagnosed with diffuse large B-cell lymphoma with cardiac involvement, where early diagnosis prevented cardiac complications from the disease and its treatment as well. The aim of this case report is to highlight the fact that cardiac involvement in lymphoma is frequent and can be easily missed, leading to complications. Treatment requires an individualized approach.
Assuntos
Neoplasias Cardíacas , Linfoma Difuso de Grandes Células B , Humanos , Feminino , Idoso , Linfoma Difuso de Grandes Células B/patologia , Linfoma Difuso de Grandes Células B/diagnóstico , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/complicações , Ecocardiografia , Septo Interatrial/patologia , Septo Interatrial/diagnóstico por imagem , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêuticoRESUMO
BACKGROUND: Primary cardiac synovial sarcoma is a rare condition with limited treatment options for advanced stages. Surgery and chemotherapy are currently the mainstay treatments; however, survival rates remain low. CASE PRESENTATION: A 64-year-old woman presenting with symptoms of chest tightness and shortness of breath was found to have an obstructive right atrial mass, along with pulmonary infarction and metastasis. She was ultimately diagnosed with advanced primary cardiac synovial sarcoma. Following surgery, the patient's symptoms improved, and she underwent chemotherapy and anti-angiogenic therapy, but unfortunately, her survival time was only 8 months. CONCLUSION: This case report aims to enhance clinicians' understanding of the diagnosis and treatment of primary cardiac synovial sarcoma. Enhancing both survival outcomes and quality of life in individuals with primary cardiac synovial sarcoma continues to present a significant challenge.
Assuntos
Neoplasias Cardíacas , Infarto Pulmonar , Sarcoma Sinovial , Humanos , Sarcoma Sinovial/patologia , Sarcoma Sinovial/complicações , Sarcoma Sinovial/diagnóstico , Feminino , Pessoa de Meia-Idade , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/complicações , Infarto Pulmonar/patologia , Infarto Pulmonar/etiologia , Septo Interatrial/patologiaRESUMO
BACKGROUND Cervical cancer ranks fourth globally among women's cancers. Squamous cell carcinoma constitutes 70% of cervical cancer cases, often metastasizing to lungs and paraaortic nodes. Uncommon sites include the brain, skin, spleen, and muscle, while pericardial fluid metastasis is highly rare. We report a case of squamous cell carcinoma of the uterine cervix that was metastatic to the pericardium and was detected on cytologic evaluation of pericardial fluid. CASE REPORT A 42-year-old woman who was previously treated for stage III squamous cell carcinoma of the cervix presented with symptoms of cough, fever, and shortness of breath for 8 days, and chest pain for 3 days. Clinical workup revealed pericardial effusion, with spread to the lungs and mediastinal and hilar lymph nodes. Cytological analysis of the fluid showed malignant cells, consistent with metastatic squamous cell carcinoma. Immunohistochemistry demonstrated cells positive for p63 and p40, while negative for GATA-3, D2-40, calretinin, and WT1. These findings in conjunction with patient's known history of cervical squamous cell carcinoma was consistent with a cytologic diagnosis of metastatic squamous cell carcinoma to pericardial fluid. CONCLUSIONS History and clinical correlation plays a vital role in determining the primary site causing malignant pericardial effusions. While the occurrence of cervical cancer metastasizing to the pericardium is uncommon, it should be considered, particularly in cases involving high-grade, invasive tumors, recurrences, or distant metastases. This possibility should be included in the list of potential diagnoses when encountering pericardial effusions with squamous cells in female patients.
Assuntos
Carcinoma de Células Escamosas , Derrame Pericárdico , Neoplasias do Colo do Útero , Humanos , Feminino , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/secundário , Carcinoma de Células Escamosas/complicações , Derrame Pericárdico/etiologia , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/complicações , Adulto , Neoplasias Cardíacas/secundário , Neoplasias Cardíacas/complicações , Neoplasias Cardíacas/patologiaRESUMO
ABSTRACT: Lipomatous hypertrophy of the interatrial septum (LHIS) is a rare but benign cardiac tumor that can be found on cardiac imaging such as echocardiogram, or during surgery or an autopsy. Cardiac MRI is the best imaging modality to determine the borders of the tumor and its extension into the intraventricular septum and ventricular free wall. Patients require close monitoring because LHIS may cause right or left outflow tract obstruction or superior vena cava obstruction, requiring cardiac surgical intervention. This article describes a patient with LHIS who underwent cardiac surgery because of her increasing symptomatology.
Assuntos
Septo Interatrial , Neoplasias Cardíacas , Lipomatose , Humanos , Feminino , Septo Interatrial/diagnóstico por imagem , Septo Interatrial/patologia , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/cirurgia , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas/patologia , Lipomatose/diagnóstico por imagem , Lipomatose/diagnóstico , Lipomatose/cirurgia , Imageamento por Ressonância Magnética , Hipertrofia , Ecocardiografia , Pessoa de Meia-Idade , Lipoma/cirurgia , Lipoma/diagnóstico por imagem , Lipoma/diagnósticoRESUMO
Cardiac myxoma is a commonly encountered tumor within the heart that has the potential to be life-threatening. However, the cellular composition of this condition is still not well understood. To fill this gap, we analyzed 75,641 cells from cardiac myxoma tissues based on single-cell sequencing. We defined a population of myxoma cells, which exhibited a resemblance to fibroblasts, yet they were distinguished by an increased expression of phosphodiesterases and genes associated with cell proliferation, differentiation, and adhesion. The clinical relevance of the cell populations indicated a higher proportion of myxoma cells and M2-like macrophage infiltration, along with their enhanced spatial interaction, were found to significantly contribute to the occurrence of embolism. The immune cells surrounding the myxoma exhibit inhibitory characteristics, with impaired function of T cells characterized by the expression of GZMK and TOX, along with a substantial infiltration of tumor-promoting macrophages expressed growth factors such as PDGFC. Furthermore, in vitro co-culture experiments showed that macrophages promoted the growth of myxoma cells significantly. In summary, this study presents a comprehensive single-cell atlas of cardiac myxoma, highlighting the heterogeneity of myxoma cells and their collaborative impact on immune cells. These findings shed light on the complex pathobiology of cardiac myxoma and present potential targets for intervention.
Assuntos
Neoplasias Cardíacas , Mixoma , Microambiente Tumoral , Humanos , Mixoma/patologia , Mixoma/genética , Mixoma/imunologia , Microambiente Tumoral/imunologia , Microambiente Tumoral/genética , Neoplasias Cardíacas/genética , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/imunologia , Macrófagos/imunologia , Macrófagos/patologia , Proliferação de Células/genética , Masculino , FemininoRESUMO
Cardiac myxoma is extremely rare in children. However, if not treated immediately, it may cause varying symptoms until sudden death. A-9-years old male Javanese child was brought to the emergency department of Prof. Soekandar General Hospital, Mojokerto with progressive dyspnoea since one month which got worse in the left decubitus position. There was no significant past medical history. Physical examination revealed hypotension, mitral stenosis, tricuspid regurgitation, and pulmonary congestion. Transthoracic echocardiography revealed a round pedunculated 3x3.3 cm mass in the Left Atrium that swingingly moved to the Left Ventricle during diastole. This was diagnosed provisionally as Myxoma with a differential of thrombus. After stabilization, he was referred to a tertiary hospital for emergency excision. Histopathology confirmed the myxoma. There were no symptoms and activity limitations during the 6 months follow-up. To the best of our knowledge, this is the first paediatric cardiac myxoma with Acute Heart Failure symptoms reported in Indonesia. Echocardiography is imperative for diagnosing myxoma. Appropriate and timely management results in an excellent outcome.
Assuntos
Ecocardiografia , Insuficiência Cardíaca , Neoplasias Cardíacas , Mixoma , Humanos , Mixoma/complicações , Mixoma/cirurgia , Mixoma/diagnóstico , Neoplasias Cardíacas/complicações , Neoplasias Cardíacas/cirurgia , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas/diagnóstico por imagem , Masculino , Insuficiência Cardíaca/etiologia , Criança , Dispneia/etiologia , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/patologia , Doença AgudaAssuntos
Fibroelastoma Papilar Cardíaco , Humanos , Fibroelastoma Papilar Cardíaco/cirurgia , Fibroelastoma Papilar Cardíaco/patologia , Fibroelastoma Papilar Cardíaco/diagnóstico por imagem , Fibroelastoma Papilar Cardíaco/diagnóstico , Feminino , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/cirurgia , Neoplasias Cardíacas/patologia , Masculino , Fibroma/cirurgia , Fibroma/patologia , AdultoRESUMO
BACKGROUND: Primary cardiac tumors, while rare, present significant clinical challenges due to their diverse pathology and presentation. Lung cancer frequently metastasizes to the heart; however, cases involving primary cardiac tumors of different origins alongside primary lung cancer are exceedingly rare in the literature. CASE PRESENTATION: We report the case of a 53-year-old female who presented with hemoptysis and was subsequently diagnosed with a left atrial myxoma, pulmonary squamous cell carcinoma, and a thymic cyst. This coexistence of multiple non-homologous tumors in a single patient is exceedingly rare. CONCLUSION: This case underscores the complexity of diagnosing and managing patients with multiple distinct tumors. The simultaneous occurrence of a primary cardiac myxoma, pulmonary squamous cell carcinoma, and thymic cyst is unprecedented, providing valuable insights for future clinical practice.
Assuntos
Carcinoma de Células Escamosas , Átrios do Coração , Neoplasias Cardíacas , Neoplasias Pulmonares , Cisto Mediastínico , Mixoma , Humanos , Mixoma/complicações , Mixoma/cirurgia , Mixoma/patologia , Feminino , Pessoa de Meia-Idade , Carcinoma de Células Escamosas/cirurgia , Carcinoma de Células Escamosas/complicações , Carcinoma de Células Escamosas/patologia , Neoplasias Pulmonares/cirurgia , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/patologia , Cisto Mediastínico/cirurgia , Cisto Mediastínico/complicações , Cisto Mediastínico/patologia , Neoplasias Cardíacas/cirurgia , Neoplasias Cardíacas/complicações , Neoplasias Cardíacas/patologia , Átrios do Coração/patologia , Átrios do Coração/cirurgia , Neoplasias Primárias Múltiplas/cirurgia , Neoplasias Primárias Múltiplas/patologia , Neoplasias Primárias Múltiplas/complicaçõesRESUMO
ST-segment elevation on the electrocardiogram typically indicates acute myocardial infarction but can mimic ST-segment elevation myocardial infarction in various conditions. We present a case of a patient with an intramyocardial mass and anterior ST-segment elevation without significant myocardial biomarker elevation. Multimodality imaging was crucial in revealing cardiac metastasis as the attributable cause.
Assuntos
Eletrocardiografia , Neoplasias Cardíacas , Infarto do Miocárdio com Supradesnível do Segmento ST , Humanos , Infarto do Miocárdio com Supradesnível do Segmento ST/diagnóstico , Diagnóstico Diferencial , Neoplasias Cardíacas/secundário , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/diagnóstico , Masculino , Pessoa de Meia-IdadeAssuntos
Protocolos de Quimioterapia Combinada Antineoplásica , Neoplasias Cardíacas , Embolia Pulmonar , Humanos , Embolia Pulmonar/prevenção & controle , Embolia Pulmonar/epidemiologia , Embolia Pulmonar/etiologia , Neoplasias Cardíacas/complicações , Incidência , Masculino , Feminino , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Idoso , Ciclofosfamida/administração & dosagem , Ciclofosfamida/uso terapêutico , Vincristina/administração & dosagem , Vincristina/uso terapêutico , Doxorrubicina/uso terapêutico , Doxorrubicina/administração & dosagem , Rituximab/uso terapêutico , Rituximab/administração & dosagem , Pessoa de Meia-Idade , Prednisona/uso terapêutico , Prednisona/administração & dosagem , Etoposídeo/administração & dosagem , Etoposídeo/uso terapêutico , Estudos RetrospectivosRESUMO
The objective of this study was to evaluate semi-quantitatively the diagnostic performance of PET/CT metabolic parameters in differentiating benign or malignant cardiac or pericardial masses. A total of forty-one patients with newly diagnosed cardiac/pericardial masses who underwent 18F-FDG PET/CT were recruited. PET/CT metabolic parameters including the maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), total lesion glycolysis (TLG), tumor metabolic volume (MTV), the maximum tumor-to-mediastinal background ratio (TMR) and the maximum tumor-to-liver background ratio (TLR) is measured or calculated to evaluate the benign or malignant nature of cardiac/pericardial masses. Compared with benign cardiac/pericardial lesions, cardiac/pericardial malignancies had higher SUVmax, SUVmean, TLG, MTV, TMR, and TLR. All these PET/CT metabolic parameters showed high diagnostic performance in semi-quantitative evaluation of benign or malignant cardiac or pericardial masses, and SUVmean and MTV had the highest diagnostic accuracy. Therefore, PET/CT metabolic parameters can semi-quantitatively evaluate the benign or malignant cardiac/pericardial masses.
Assuntos
Fluordesoxiglucose F18 , Neoplasias Cardíacas , Pericárdio , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Humanos , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos , Masculino , Feminino , Pessoa de Meia-Idade , Estudos Retrospectivos , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/metabolismo , Idoso , Pericárdio/diagnóstico por imagem , Pericárdio/metabolismo , Pericárdio/patologia , Adulto , Compostos Radiofarmacêuticos , Idoso de 80 Anos ou maisRESUMO
Malignant melanoma (MM) is notorious for its high metastatic potential, with cardiac metastasis being particularly severe as it involves cardiac structures and can lead to significant cardiac functional issues. While there is no standardized treatment approach, early detection and intervention can improve prognosis.
Assuntos
Ecocardiografia , Neoplasias Cardíacas , Neoplasias Intestinais , Melanoma , Humanos , Melanoma/secundário , Neoplasias Cardíacas/secundário , Neoplasias Cardíacas/diagnóstico por imagem , Ecocardiografia/métodos , Neoplasias Intestinais/secundário , Neoplasias Intestinais/diagnóstico por imagem , Masculino , Intestino Delgado , Pessoa de Meia-IdadeRESUMO
Background: Esophageal cancer (EC) comprises 1% of all diagnosed cancers in the USA. It is more common in other parts of the world. If there is distant metastasis, the relative survival rate is 6%. There are no standardized screening methods for EC. Case Presentation: We reported a four-year case of esophageal cancer, a P53-positive mutation with atypical distant metastasis to the cardiac and skeletal muscles. The patient was managed with multimodal therapy, including immunotherapy, which could have been a factor in prolonged survival. Conclusions: Distant metastases are typically seen postmortem, and with prolonged survival, we are able to find such unique metastases antemortem. Despite a history of negative scans, the patient's ctDNA (circulating tumor DNA) remained positive, which was a better predictor of recurrence in this case. Future research is required to establish cost-effective screening methods and standardized treatments.
Assuntos
Neoplasias Esofágicas , Neoplasias Cardíacas , Humanos , Neoplasias Cardíacas/secundário , Masculino , Neoplasias Musculares/secundário , Neoplasias Musculares/diagnóstico por imagem , Músculo Esquelético , Pessoa de Meia-Idade , DNA Tumoral Circulante/sangue , DNA Tumoral Circulante/análise , IdosoRESUMO
BACKGROUND: Recent studies provide compelling evidence linking the gut microbiota to most cancers. Nevertheless, further research is required to establish a definitive causal relationship between the gut microbiota and malignant cardiac tumors. METHODS: The genome-wide association studies (GWAS) data on the human gut Microbiota, included in the IEU Open GWAS project, was initially collected by the MiBioGen consortium. It encompasses 14,306 individuals and comprises a total of 5,665,279 SNPs. Similarly, the GWAS data on malignant cardiac tumors, also sourced from the IEU Open GWAS project, was initially stored in the finnGen database, including 16,380,303 SNPs observed within a cohort of 174,108 individuals within the European population. Utilizing a two-sample Mendelian randomization (MR) methodology, we examined whether there exists a causal association between the gut microbiota and cardiac tumors. Additionally, to bolster the credibility and robustness of the identified causal relationships, we conducted an extensive array of sensitivity analyses, encompassing Cochran's Q test, MR-PRESSO tests, MR-Egger interpret test, directionality test and leave-one-out analysis. RESULTS: Our analysis unveiled seven distinct causal associations between genetic susceptibility in the gut microbiota and the incidence of malignant cardiac tumors. Among these, the Family Rikenellaceae, genus Eubacterium brachy group, and genus Ruminococcaceae UCG009 exhibited an elevated risk of cardiac tumors, while the phylum Verrucomicrobia, genus Lactobacillus, genus Ruminiclostridium5, and an unknown genus id.1868 were genetically linked to a reduced risk of cardiac tumors. The causal relationship between these two bacteria, belonging to the phylum Verrucomicrobia (OR = 0.178, 95% CI: 0.052-0.614, p = 0.006) and the genus Ruminococcaceae UCG009 (OR = 3.071, 95% CI: 1.236-7.627, p = 0.016), and cardiac tumors was further validated through sensitivity analyses, reinforcing the robustness and reliability of the observed associations. CONCLUSION: Our MR analysis confirms that the phylum Verrucomicrobia displays significant protection against cardiac tumor, and the genus Ruminococcaceae UCG009 leads to an increasing risk of cardiac tumor.