Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 6.897
Filtrar
1.
Sci Rep ; 14(1): 10660, 2024 05 09.
Artigo em Inglês | MEDLINE | ID: mdl-38724525

RESUMO

Influenza Like Illness (ILI) and Severe Acute Respiratory Infection (SARI) cases are more prone to Influenza and SARS-CoV-2 infection. Accordingly, we genetically characterized Influenza and SARS-CoV-2 in 633 ILI and SARI cases by rRT-PCR and WGS. ILI and SARI cases showed H1N1pdm09 prevalence of 20.9% and 23.2% respectively. 135 (21.3%) H1N1pdm09 and 23 (3.6%) H3N2 and 5 coinfection (0.78%) of H1N1pdm09 and SARS-CoV-2 were detected. Phylogenetic analysis revealed H1N1pdm09 resemblance to clade 6B.1A.5a.2 and their genetic relatedness to InfA/Perth/34/2020, InfA/Victoria/88/2020 and InfA/Victoria/2570/2019. Pan 24 HA and 26 NA nonsynonymous mutations and novel HA (G6D, Y7F, Y78H, P212L, G339R, T508K and S523T) and NA (S229A) mutations were observed. S74R, N129D, N156K, S162N, K163Q and S164T alter HA Cb and Sa antibody recognizing site. Similarly, M19T, V13T substitution and multiple mutations in transmembrane and NA head domain drive antigenic drift. SARS-CoV-2 strains genetically characterized to Omicron BA.2.75 lineage containing thirty nonsynonymous spike mutations exhibited enhanced virulence and transmission rates. Coinfection although detected very minimal, the mutational changes in H1N1pdm09 and SARS-CoV-2 virus infected individuals could alter antibody receptor binding sites, allowing the viruses to escape immune response resulting in better adaptability and transmission. Thus continuous genomic surveillance is required to tackle any future outbreak.


Assuntos
COVID-19 , Vírus da Influenza A Subtipo H1N1 , Influenza Humana , Filogenia , SARS-CoV-2 , Humanos , Vírus da Influenza A Subtipo H1N1/genética , SARS-CoV-2/genética , Influenza Humana/virologia , Influenza Humana/epidemiologia , COVID-19/virologia , COVID-19/epidemiologia , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Adolescente , Adulto Jovem , Genoma Viral/genética , Idoso , Coinfecção/virologia , Coinfecção/epidemiologia , Criança , Pré-Escolar , Síndrome Respiratória Aguda Grave/virologia , Síndrome Respiratória Aguda Grave/epidemiologia , Mutação , Lactente
2.
An. pediatr. (2003. Ed. impr.) ; 100(4): 268-274, abril 2024. ilus
Artigo em Espanhol | IBECS | ID: ibc-232097

RESUMO

Durante el embarazo, los cambios fisiológicos en la respuesta inmunitaria favorecen que las gestantes sean más susceptibles a infecciones graves, tanto para ellas como para el feto, el recién nacido y el lactante. Todas las mujeres deberían entrar en el período reproductivo con su calendario vacunal correctamente cumplimentado, sobre todo en lo que respecta a enfermedades como tétanos, hepatitisB, sarampión, rubeola y varicela. Además de las vacunas recomendadas, en situaciones de riesgo las vacunas inactivadas podrían ser administradas en aquellas mujeres que no estuvieran correctamente inmunizadas con anterioridad, mientras que las atenuadas están contraindicadas.A pesar de que la vacunación durante el embarazo es una medida preventiva muy importante, y de las recomendaciones de autoridades sanitarias, sociedades científicas y profesionales sanitarios, las coberturas vacunales son claramente mejorables, especialmente en lo que respecta a gripe y COVID-19, por lo que todo profesional sanitario que atienda a la embarazada debe ser proactivo en aconsejarlas.La Asociación Española de Pediatría (AEP), a través de su Comité Asesor de Vacunas (CAV), y la Sociedad Española de Ginecología y Obstetricia (SEGO) recomiendan las siguientes vacunaciones durante la gestación: frente a gripe y COVID-19, en cualquier trimestre del embarazo, y durante el puerperio (hasta los 6meses) en aquellas que no hubieran sido vacunadas durante la gestación; frente a tosferina con Tdpa, entre las 27 y 36 semanas de gestación (el CAV-AEP da preferencia entre las 27 y 28 semanas); y frente al VRS con RSVPreF, entre las 24 y 36 semanas de gestación, de preferencia entre las 32 y 36 semanas. (AU)


During pregnancy, physiological changes in the immune response make pregnant women more susceptible to serious infection, increasing the risk for the mother as well as the foetus, newborn and infant. All women should be correctly and fully vaccinated as they enter their reproductive years, especially against diseases such as tetanus, hepatitisB, measles, rubella and varicella. In addition to the recommended vaccines, in risk situations, inactivated vaccines could be administered to women who were not correctly vaccinated before, while attenuated vaccines are contraindicated.Despite the fact that vaccination during pregnancy is a very important preventive measure and the existing recommendations from public health authorities, scientific societies and health professionals, the vaccination coverage could clearly be improved, especially against influenza and SARS-CoV-2, so any health professional involved in the care of pregnant women should proactively recommend these vaccines.The Spanish Association of Pediatrics (AEP), through its Advisory Committee on Vaccines (CAV), and the Spanish Society of Gynaecology and Obstetrics (SEGO) recommend vaccination against the following diseases during pregnancy: against influenza and COVID-19, in any trimester of pregnancy and during the postpartum period (up to 6months post birth) in women not vaccinated during pregnancy; against pertussis, with the Tdap vaccine, between weeks 27 and 36 of gestation (in the CAV-AEP recommendations, preferably between weeks 27 and 28); and against RSV, with RSVPreF, between weeks 24 and 36 of gestation, preferably between weeks 32 and 36. (AU)


Assuntos
Humanos , Gravidez , Vacinação , Coqueluche , Influenza Humana , Síndrome Respiratória Aguda Grave
3.
Rev Bras Epidemiol ; 27: e240019, 2024.
Artigo em Inglês, Português | MEDLINE | ID: mdl-38655946

RESUMO

OBJECTIVE: To analyze the influence of individual and contextual factors of the hospital and the municipality of care on the survival of patients with Severe Acute Respiratory Syndrome due to COVID-19. METHODS: Hospital cohort study with data from 159,948 adults and elderly with Severe Acute Respiratory Syndrome due to COVID-19 hospitalized from January 1 to December 31, 2022 and reported in the Influenza Epidemiological Surveillance Information System. The contextual variables were related to the structure, professionals and equipment of the hospital establishments and socioeconomic and health indicators of the municipalities. The outcome was hospital survival up to 90 days. Survival tree and Kaplan-Meier curves were used for survival analysis. RESULTS: Hospital lethality was 30.4%. Elderly patients who underwent invasive mechanical ventilation and were hospitalized in cities with low tax collection rates had lower survival rates compared to other groups identified in the survival tree (p<0.001). CONCLUSION: The study indicated the interaction of contextual factors with the individual ones, and it shows that hospital and municipal characteristics increase the risk of death, highlighting the attention to the organization, operation, and performance of the hospital network.


Assuntos
COVID-19 , Mortalidade Hospitalar , Humanos , COVID-19/mortalidade , COVID-19/epidemiologia , COVID-19/complicações , Brasil/epidemiologia , Masculino , Feminino , Idoso , Pessoa de Meia-Idade , Adulto , Síndrome Respiratória Aguda Grave/mortalidade , Síndrome Respiratória Aguda Grave/epidemiologia , Fatores Socioeconômicos , Idoso de 80 Anos ou mais , Estudos de Coortes , Adulto Jovem , Hospitalização/estatística & dados numéricos , Fatores de Risco , SARS-CoV-2 , Adolescente , Taxa de Sobrevida , Estimativa de Kaplan-Meier
4.
Rev. Ciênc. Plur ; 10 (1) 2024;10(1): 34416, 2024 abr. 30. tab
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-1553426

RESUMO

Introdução: Infecções nosocomiais, adquiridas após a internação hospitalar, são o evento adverso mais comum que ameaça a saúde dos pacientes hospitalizados, sendo a pneumonia, incluindo a causada pelo SARS-Cov-2, responsável por mais de 80% das infecções nosocomiais. A pandemia declarada pela OMS em março de 2020 reflete o rápido aumento de casos, impulsionado pela disseminação do vírus através de gotículas e aerossóis. A transmissão nosocomial do SARS-Cov-2 foi observada desde o início do surto em Wuhan, representando um desafio adicional na qualidade de vida dos pacientes. Estudos internacionais em hospitais reportam incidências de infecção nosocomial por COVID-19 entre 11% e 44%.Objetivo: Identificar a proporção de infecção nosocomial por SARS-COV-2 no Brasil entre março de 2020 até dezembro de 2022.Metodologia:Trata-se de um estudo analítico, retrospectivo, de corte transversal, sobre a proporção de infecção nosocomial por Sars-Cov-2 no Brasil, através de dados secundários oriundos do Sistema de Informação da Vigilância Epidemiológica da Gripe. No presente estudo a variável dependente analisada foi a proporção de infecção nosocomial por Sars-cov-2. Como variáveis independentes exploratórias foram utilizadas: faixa etária, sexo, comorbidades e macrorregião de residência. Resultados: O estudo identificou uma proporção de casos nosocomiais de 2,58%, sendo maior no terceiro ano da pandemia 2022 (5,5%) na região Norte (7,57%), entre os indivíduos de 18-59 anos de idade (6,93%)Conclusões: Este estudo sobre casos nosocomiais de COVID-19 no Brasil revela uma proporção de 2,58% entre 2020 e 2022, com associações identificadas em relação à região, idade e comorbidades. Diferenças em relação a estudos internacionais sugerem questões metodológicas específicas. Essa pesquisa é de importância crítica, visto ser de abrangência nacional com grande amplitude, e estabelece uma base sólida para futuros estudos epidemiológicos (AU).


Introduction: Nosocomial infections, acquired after hospital admission, are the most common adverse events threatening patient health, with pneumonia, including that caused by SARS-CoV-2, responsible for over 80% of nosocomial infections. The pandemic declared by the WHO in March 2020 reflects the rapid rise in cases driven by the virus's spread through droplets and aerosols. Nosocomial transmission of SARS-CoV-2 has been observed since the outbreak's onset in Wuhan, posing an additional challenge to patient quality of life. International hospital studies report nosocomial COVID-19 infection rates between 11% and 44%. Objective: Identifying the proportion of nosocomial SARS-CoV-2 infection in Brazil between March 2020 and December 2022.Methodology:This is an analytical, retrospective, cross-sectional study on the proportion of nosocomial SARS-CoV-2 infection in Brazil, using secondary data from the Influenza Epidemiological Surveillance Information System. In this study, the analyzed dependent variable was the proportionof nosocomial SARS-CoV-2 infection. The exploratory independent variables included: age group, gender, comorbidities, and macro-region of residence.Results:The study identified a proportion of nosocomial cases of 2.58%, with a higher proportion in the third year of the pandemic, 2022 (5.5%) in the North region (7.57%), among individuals aged 18-59 years (6.93%). Conclusions: This study on nosocomial cases of COVID-19 in Brazil reveals a proportion of 2.58% between 2020 and 2022, with associations identified regarding region, age, and comorbidities. Differences compared to international studies suggest specific methodological issues. This research is of critical importance, given its national scope and broad coverage, and establishes a solid foundation for future epidemiological studies (AU).


Introducción: Las infecciones nosocomiales, adquiridas tras la hospitalización, son el evento adverso más común que amenaza la salud de los pacientes hospitalizados, siendo la neumonía, incluida la causada por el SARS-Cov-2, la responsable de más del 80% de las infecciones. La pandemia declarada por la OMS en marzo de 2020 refleja el rápido aumento de casos, impulsado por la propagación del virus a través de gotitas y aerosoles. La transmisión nosocomial del SRAS-Cov-2 se ha observado desde el inicio del brote en Wuhan, lo que supone un reto adicional para la calidad de vida de los pacientes. Estudios internacionales realizados en hospitales informan de incidencias de infecciones nosocomiales por COVID-19 de entre el 11% y el 44%. Objetivo: Identificar la proporción de infección nosocomial por SARS-CoV-2 en Brasil entre marzo de 2020 y diciembre de 2022. Metodología: Se trata de un estudio analítico, retrospectivo y transversal sobre la proporción de infección nosocomial por SARS-CoV -2 en Brasil, utilizando datos secundarios del Sistema de Información de Vigilancia Epidemiológica de Influenza. La variable dependiente analizada fue la proporción de infección nosocomial por SARS-CoV-2. Como variables independientes exploratorias se utilizaron: grupo de edad, sexo, comorbilidades y macrorregión de residencia. Resultados:El estudio identificó una proporción de casos nosocomiales del 2,58%, siendo mayor en el tercer año de la pandemia de 2022 (5,5%) en la región Norte (7,57%), entre individuos de 18 a 59 años (6,93%). Conclusiones:Este estudio de casos de COVID-19 hospitalizados en Brasil revela una proporción de 2,58% entre 2020 y 2022, con asociaciones identificadas en relación a la región, edad y comorbilidades. Las disparidades en relación a estudios internacionales sugieren la presencia de cuestiones metodológicas específicas. Esta investigación es de extrema importancia para orientar estrategias preventivas y mejorar el control de las infecciones hospitalarias (AU).


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Infecção Hospitalar/transmissão , Registros Eletrônicos de Saúde/instrumentação , Sistemas de Informação em Saúde , COVID-19/transmissão , Brasil/epidemiologia , Estudos Retrospectivos , Síndrome Respiratória Aguda Grave/etiologia
5.
Folia Microbiol (Praha) ; 69(2): 459-464, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38353790

RESUMO

Portable household air purifiers are widely used devices designed to maintain a high-quality level of indoor air. Portable air purifiers equipped with the high-efficiency air (HEPA) filter served 100 h in a household space occupied by two adults without any symptoms of respiratory tract infection. The main objective of the study was to determine microbial contamination on the HEPA filter and to investigate if the selected nanotextile monolayer made of polyamide 6 (PA6) nanofibers can capture potential microorganisms when installed downstream of the HEPA filter as the final filtration medium. Samples were taken from the inlet and outlet surfaces. Samples from the nanotextile were collected in the same manner as from the HEPA filter. QIAStat DX® 1.0 Analyzer using the Respiratory SARS CoV-2 Panel multiplex PCR detection system was selected for microorganism detection. Adenovirus was detected on the inlet surface of the HEPA filter. The outlet surface of the filter contained no viruses included in the Respiratory SARS CoV-2 Panel portfolio. The nanotextile monolayer was replaced twice during the 100 h of operation, so three pieces were used and all contained coronavirus 229 E. Coronavirus 229 E was then detected in the nasopharynx of one of the members of the household as well. It may be assumed that the selected nanotextile is capable of capturing a virus of a small size.


Assuntos
Filtros de Ar , Síndrome Respiratória Aguda Grave , Humanos , Projetos Piloto , Filtração , SARS-CoV-2
6.
Biochim Biophys Acta Biomembr ; 1866(2): 184259, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38061554

RESUMO

The heptad repeat 1 and 2 (HR1, HR2) regions in the spike protein of SARS-CoV 2 play a key role in the fusogenic mechanism of the virus with the host cell. During the fusion process they are thought to rearrange into an interdomain multimer. Functional fragments of the heptad repeat 1 and 2 regions in the spike protein of SARS-CoV 2 were chemically synthesized, labeled with nitrofurazone (NBD) and their interactions investigated by fluorescence spectroscopy. Steady state emission, fluorescence quenching, anisotropy and lifetime measurements in combination with a fluorophore dilution scheme were used to dissect multimer formation of HR1 and HR2 in quantitative detail. In addition, the investigation of the multimers by homo-FRET (via anisotropy) and lifetime measurements reveals new insights into the mechanism of fluorophore-fluorophore interactions in biological samples.


Assuntos
COVID-19 , Síndrome Respiratória Aguda Grave , Humanos , Glicoproteína da Espícula de Coronavírus/metabolismo , Proteínas do Envelope Viral/química , Glicoproteínas de Membrana/metabolismo , SARS-CoV-2/metabolismo
7.
Sudan j. med. sci ; 19(1): 90-97, 2024. figures, tables
Artigo em Inglês | AIM (África) | ID: biblio-1552435

RESUMO

Background: COVID-19 is a global pandemic caused by SARS_COV2. The symptoms of covid-19 include: fever, dyspnea, fatigue, a recent loss of smell and taste, sore throat, cough, and cutaneous lesions. In addition, some skin manifestations were reported to be associated with COVID-19. Methods: The study design is a descriptive cross-sectional hospital-based study. The study aimed to evaluate the level of knowledge and practice about skin manifestations of COVID-19 among doctors working at Khartoum dermatology and venereology teaching hospital. A self-administrated questionnaire was used for data collection after an informed consent was taken. Results: Among 140 doctors working in the dermatology and venereology teaching hospital, 75.7% of the doctors had knowledge that COVID-19 can present with skin manifestations. The study results showed that about half of the participants have poor knowledge about COVID-19 skin manifestations while 25% have no knowledge, and that 35 (25%) doctors have good knowledge. From a total of 140 doctors; 46.4% reported that when patients present with COVID-19 skin lesions, they will isolate them in separate rooms and call the epidemiology center, whereas, 61 doctors (43.6%) did not know if they have a protocol for COVID-19 suspected cases. This study reported a significant association between job category and level of knowledge toward COVID-19 skin manifestations measured by Chi-square test, the P-value was 0.003 (significant at 0.05), and the same significant association was found between the year of rotation and knowledge. Conclusion: Half of the doctors covered by this study had poor knowledge about COVID-19 skin manifestations, and therefore, educating doctors in dermatology hospitals about skin manifestations of COVID-19 is recommended, besides clear and precise guidelines and protocols for diagnosis and management.


Assuntos
Sinais e Sintomas , Manifestações Cutâneas , Conhecimentos, Atitudes e Prática em Saúde , Síndrome Respiratória Aguda Grave , COVID-19
8.
Braz J Infect Dis ; 27(6): 103702, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38043582

RESUMO

Respiratory Syncytial Virus (RSV) poses a global health concern, particularly affecting young children, the elderly, and immunosuppressed individuals. RSV viral load is essential for understanding transmission, disease severity, prevention, and treatment. This retrospective study aimed to analyze the frequency rates and viral loads of RSV infections in different patient cohorts and age groups over an eight-year period in a university hospital in São Paulo, Brazil. This study analyzed 1380 Immunocompetent (IC) and Immunosuppressed (IS) patients with acute respiratory tract infections. IC included patients with chronic Heart Disease (HD), Primary Care service recipients (PC), and a subgroup suspected of having Severe Acute Respiratory Syndrome caused by Influenza A (H1N1)pdm09 virus (SARS H1N1). IS comprised transplant patients and those with HIV infection. Respiratory samples were collected between February 2005 and October 2013, with RSV detection and viral load quantification (Log10 copies of RNA/mL) using RT-qPCR. Overall RSV infection rate was 17.3 %, with higher rates in children (23.9 %) than in adults (12.9 %), particularly in children under two years of age (28.2 %). Children in the SARS H1N1 and PC subgroups had higher infection rates (16.4 % and 34.9 %, respectively), with the highest rate in PC children aged 1 to < 2 years (45.45 %). Adults with HD had a significantly higher frequency rate (27.83 %) than those in the SARS H1N1 (2.65 %) and IS (15.16 %) subgroups and higher hospitalization rate among adults under 65 years. RSV viral load ranged from 2.43 to 10.15 Log10 RNA copies/mL (mean ± SD 5.82 ± 2.19), with hospitalized patients exhibiting significantly higher viral loads (7.34 ± 1.9) than outpatients (4.38 ± 1.89). Elderly bone marrow transplant patients also had significantly higher viral loads (7.57 ± 2.41) than younger adults (5.12 ± 1.87). This study provides insights into the RSV infection patterns in different patient cohorts in Brazil. Further investigations are needed to understand susceptibility and risk factors associated with RSV infection. In conclusion, high RSV viral load among hospitalized patients could serve as a surrogate marker of disease severity. Additionally, patients with chronic heart disease deserve greater attention regarding complications associated with RSV infection.


Assuntos
Infecções por HIV , Cardiopatias , Vírus da Influenza A Subtipo H1N1 , Infecções por Vírus Respiratório Sincicial , Vírus Sincicial Respiratório Humano , Infecções Respiratórias , Síndrome Respiratória Aguda Grave , Criança , Adulto , Idoso , Humanos , Lactente , Pré-Escolar , Infecções por Vírus Respiratório Sincicial/epidemiologia , Carga Viral , Brasil/epidemiologia , Estudos Retrospectivos , Doença Crônica , Hospitais Universitários , RNA
9.
Int. j. morphol ; 41(6): 1687-1697, dic. 2023. ilus
Artigo em Inglês | LILACS | ID: biblio-1528806

RESUMO

SUMMARY: In response to the threat posed by new variants of SARS-CoV-2 and the urgent need for effective treatments in the absence of vaccines, the aim of this study was to develop a rapid and cost-effective hyperimmune serum (HS) derived from sheep and assess its efficacy. The utilization of a halal-certified, easily maintained in certain geographic regions, easy-to-handle animal such as sheep could provide a viable alternative to the expensive option of horses. Sheep were immunized with a whole inactivated SARS-CoV- 2 antigen to produce HS, which was evaluated for neutralizing potency using the PRNT50 assay. K18-hACE2 transgenic mice (n=35) were divided into three groups: control, SARS-CoV-2 exposure through inhalation, and SARS-CoV-2 exposed mice treated with HS. HS efficacy was assessed through serum proinflammatory cytokine levels, qRT-PCR analysis, histopathological examination of lungs and hearts, and transmission electron microscopy. Purified HS exhibited significant neutralizing activity (1/24,576). The SARS-CoV-2+HS group showed lower levels of TNF-α, IL-10, and IL-6 (P<0.01) and relatively lower levels of MCP-1 compared to the SARS-CoV-2 group. HS prevented death, reduced viral RNA levels in the lungs and hearts, protected against severe interstitial pneumonia, preserved lung tissue integrity, and prevented myocyte damage, while the SARS-CoV-2 group exhibited viral presence in the lungs. This study successfully developed a sheep-derived HS against the entire SARS-CoV-2 virus, resulting in a significant reduction in infection severity, inflammation, and systemic cytokine production. The findings hold promise for treating severe COVID-19 cases, including emerging viral variants, and immunocompromised patients.


En respuesta a la amenaza que suponen las nuevas variantes del SARS-CoV-2 y la urgente necesidad de tratamientos eficaces en ausencia de vacunas, el objetivo de este estudio fue desarrollar un suero hiperinmune (HS) rápido y rentable derivado de ovejas. y evaluar su eficacia. La utilización de un animal con certificación halal, de fácil mantenimiento en determinadas regiones geográficas y de fácil manejo, como las ovejas, podría proporcionar una alternativa viable a la costosa opción de los caballos. Las ovejas fueron inmunizadas con un antígeno de SARS-CoV-2 completamente inactivado para producir HS, cuya potencia neutralizante se evaluó mediante el ensayo PRNT50. Los ratones transgénicos K18-hACE2 (n = 35) se dividieron en tres grupos: control, exposición al SARS-CoV-2 mediante inhalación y ratones expuestos al SARS-CoV-2 tratados con HS. La eficacia de HS se evaluó mediante niveles de citoquinas proinflamatorias en suero, análisis qRT-PCR, examen histopatológico de pulmones y corazones y microscopía electrónica de transmisión. El HS purificado exhibió una actividad neutralizante significativa (1/24,576). El grupo SARS-CoV-2+HS mostró niveles más bajos de TNF-α, IL-10 e IL-6 (P<0,01) y niveles relativamente más bajos de MCP-1 en comparación con el grupo SARS-CoV-2. HS evitó la muerte, redujo los niveles de ARN viral en los pulmones y el corazón, protegió contra la neumonía intersticial grave, preservó la integridad del tejido pulmonar y evitó el daño de los miocitos, mientras que el grupo SARS-CoV-2 exhibió presencia viral en los pulmones. Este estudio desarrolló con éxito un HS derivado de ovejas contra todo el virus SARS-CoV-2, lo que resultó en una reducción significativa de la gravedad de la infección, la inflamación y la producción sistémica de citocinas. Los hallazgos son prometedores para el tratamiento de casos graves de COVID- 19, incluidas las variantes virales emergentes y los pacientes inmunocomprometidos.


Assuntos
Animais , COVID-19/tratamento farmacológico , Soros Imunes/administração & dosagem , Sistema Respiratório/efeitos dos fármacos , Sistema Respiratório/ultraestrutura , Ovinos , Vacinas de Produtos Inativados , Síndrome Respiratória Aguda Grave/prevenção & controle , Microscopia Eletrônica de Transmissão , Reação em Cadeia da Polimerase em Tempo Real , Citometria de Fluxo , SARS-CoV-2/efeitos dos fármacos , COVID-19/imunologia , COVID-19/prevenção & controle , Coração/efeitos dos fármacos , Cavalos , Imunoterapia/métodos , Insuficiência de Múltiplos Órgãos/prevenção & controle , Miocárdio/ultraestrutura
10.
Multimedia | Recursos Multimídia, MULTIMEDIA-SMS-SP | ID: multimedia-12352

RESUMO

Os objetivos da vigilância sentinela de Síndrome Gripal é acompanhar a circulação de vírus respiratórios identificados nas unidades sentinela e identificar prontamente novos subtipos virais circulantes.


Assuntos
Síndrome Respiratória Aguda Grave
11.
Multimedia | Recursos Multimídia, MULTIMEDIA-SMS-SP | ID: multimedia-12353

RESUMO

Os objetivos da vigilância sentinela de Síndrome Gripal é acompanhar a circulação de vírus respiratórios identificados nas unidades sentinela e identificar prontamente novos subtipos virais circulantes.


Assuntos
Síndrome Respiratória Aguda Grave
12.
Multimedia | Recursos Multimídia, MULTIMEDIA-SMS-SP | ID: multimedia-12354

RESUMO

Os objetivos da vigilância sentinela de Síndrome Gripal é acompanhar a circulação de vírus respiratórios identificados nas unidades sentinela e identificar prontamente novos subtipos virais circulantes.


Assuntos
Síndrome Respiratória Aguda Grave
13.
Multimedia | Recursos Multimídia, MULTIMEDIA-SMS-SP | ID: multimedia-12355

RESUMO

Os objetivos da vigilância sentinela de Síndrome Gripal é acompanhar a circulação de vírus respiratórios identificados nas unidades sentinela e identificar prontamente novos subtipos virais circulantes.


Assuntos
Síndrome Respiratória Aguda Grave
14.
Multimedia | Recursos Multimídia, MULTIMEDIA-SMS-SP | ID: multimedia-12356

RESUMO

Os objetivos da vigilância sentinela de Síndrome Gripal é acompanhar a circulação de vírus respiratórios identificados nas unidades sentinela e identificar prontamente novos subtipos virais circulantes.


Assuntos
Síndrome Respiratória Aguda Grave
15.
Multimedia | Recursos Multimídia, MULTIMEDIA-SMS-SP | ID: multimedia-12357

RESUMO

Os objetivos da vigilância sentinela de Síndrome Gripal é acompanhar a circulação de vírus respiratórios identificados nas unidades sentinela e identificar prontamente novos subtipos virais circulantes.


Assuntos
Síndrome Respiratória Aguda Grave
16.
Multimedia | Recursos Multimídia, MULTIMEDIA-SMS-SP | ID: multimedia-12358

RESUMO

Os objetivos da vigilância sentinela de Síndrome Gripal é acompanhar a circulação de vírus respiratórios identificados nas unidades sentinela e identificar prontamente novos subtipos virais circulantes.


Assuntos
Síndrome Respiratória Aguda Grave
17.
Multimedia | Recursos Multimídia, MULTIMEDIA-SMS-SP | ID: multimedia-12359

RESUMO

Os objetivos da vigilância sentinela de Síndrome Gripal é acompanhar a circulação de vírus respiratórios identificados nas unidades sentinela e identificar prontamente novos subtipos virais circulantes.


Assuntos
Síndrome Respiratória Aguda Grave
18.
Multimedia | Recursos Multimídia, MULTIMEDIA-SMS-SP | ID: multimedia-12360

RESUMO

Os objetivos da vigilância sentinela de Síndrome Gripal é acompanhar a circulação de vírus respiratórios identificados nas unidades sentinela e identificar prontamente novos subtipos virais circulantes.


Assuntos
Síndrome Respiratória Aguda Grave
19.
Multimedia | Recursos Multimídia, MULTIMEDIA-SMS-SP | ID: multimedia-12361

RESUMO

Os objetivos da vigilância sentinela de Síndrome Gripal é acompanhar a circulação de vírus respiratórios identificados nas unidades sentinela e identificar prontamente novos subtipos virais circulantes.


Assuntos
Síndrome Respiratória Aguda Grave
20.
Multimedia | Recursos Multimídia, MULTIMEDIA-SMS-SP | ID: multimedia-12362

RESUMO

Os objetivos da vigilância sentinela de Síndrome Gripal é acompanhar a circulação de vírus respiratórios identificados nas unidades sentinela e identificar prontamente novos subtipos virais circulantes.


Assuntos
Síndrome Respiratória Aguda Grave
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...