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2.
BMC Infect Dis ; 24(1): 293, 2024 Mar 06.
Artigo em Inglês | MEDLINE | ID: mdl-38448866

RESUMO

BACKGROUND: Colorectal cancer is one of the most frequently diagnosed forms of cancer, and it is associated with several common symptoms and signs such as rectal bleeding, altered bowel habits, abdominal pain, anemia, and unintentional weight loss. Sciatica, a debilitating condition in which the patient experiences paresthesia and pain in the dermatome of associated lumbosacral nerve roots or sciatic nerve distribution, is not considered one of these. Here we present a case of colorectal cancer manifesting symptoms of sciatica alone. CASE PRESENTATION: A 68-year-old male presented with progressive lower back pain radiating to his left thigh and calf over L5/S1 dermatome. Sciatica was suspected and initially underwent conservative treatment with analgesics. However, the symptoms progressed and MRI revealed an epidural abscess surprisingly. Surgical debridement was performed and pus culture isolated Streptococcus gallolyticus. Based on the strong association of S. gallolyticus with colorectal cancer, the presence of this pathogen prompted further tumor evaluation, even in the absence of the typical symptoms and signs. This investigation ultimately leads to the diagnosis of sigmoid adenocarcinoma. CONCLUSIONS: Although rare, sciatica caused by S. gallolyticus infection of the spinal epidural space may serve as the initial presentation of colorectal cancer. Physicians should be aware of the strong association between S. gallolyticus and colorectal cancer. Based on what we currently know about the condition; a thorough systematic assessment of occult neoplasia for patients with S. gallolyticus infection is recommended.


Assuntos
Neoplasias do Colo , Abscesso Epidural , Ciática , Masculino , Humanos , Idoso , Ciática/diagnóstico , Ciática/etiologia , Abscesso Epidural/diagnóstico , Abscesso Epidural/cirurgia , Neoplasias do Colo/complicações , Neoplasias do Colo/diagnóstico , Dor Abdominal , Conscientização
5.
World Neurosurg ; 183: e838-e845, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38218437

RESUMO

OBJECTIVES: Brucellar cervical epidural abscess (CEA) is a rare condition with potentially permanent neurological damage if left untreated. This study aims to define the clinical presentation of brucellar CEA and evaluate the outcome of surgical treatment, specifically decompression and fusion surgery. The findings will contribute to understanding whether all patients with brucellar CEA could benefit from this surgical intervention. METHODS: A retrospective study on brucellar spondylitis was conducted at the First Hospital of Jilin University from August 2018 to August 2022. During this period, a total of 37 patients were diagnosed with brucellar spondylitis at the hospital. Out of the 37 cases, six patients (16.2%) were confirmed to have CEA through cervical magnetic resonance imaging examination and serology test results.. RESULTS: Six patients were diagnosed with brucellar CEA (16.2%), of whom 5 successfully underwent anterior cervical decompression and fusion surgery. One patient had a large prevertebral abscess that could only be drained. In combination with effective antibiotic therapy, the clinical performance of the 5 patients who underwent surgery improved after the surgery. The remaining one patient required delayed surgery due to instability of the cervical spine. The follow-up period of all the 6 patients was 6 months. CONCLUSIONS: Brucellosis should be considered as a potential cause of CEA, especially in endemic areas. Timely detection and effective management of this condition are crucial in order to minimize the associated morbidity and mortality. For patients with detectable brucellar CEA, we recommend decompression and fusion surgery.


Assuntos
Brucella , Brucelose , Abscesso Epidural , Espondilite , Humanos , Abscesso Epidural/diagnóstico por imagem , Abscesso Epidural/cirurgia , Abscesso Epidural/tratamento farmacológico , Estudos Retrospectivos , Brucelose/complicações , Espondilite/complicações , Imageamento por Ressonância Magnética
8.
Instr Course Lect ; 73: 675-687, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38090933

RESUMO

The treatment of spinal infections is not well defined, and a cursory review of the literature can lead to conflicting treatment strategies. To add to the complexity, infections can include primary infection of the spine, infection secondary to another primary source, and postoperative infections including epidural abscesses, discitis, osteomyelitis, paraspinal soft-tissue infections, or any combination. Furthermore, differing opinions often exist within the medical and surgical communities regarding the outcomes and effectiveness of varying treatment strategies. Given the paucity of defined treatment protocols and long-term follow-up, it is important to develop multidisciplinary treatment teams and treatment strategies. This, along with defined protocols for the treatment of varying infections, can provide the data needed for improved treatment of spinal infections.


Assuntos
Discite , Abscesso Epidural , Osteomielite , Humanos , Discite/diagnóstico , Discite/cirurgia , Abscesso Epidural/diagnóstico , Abscesso Epidural/cirurgia , Imageamento por Ressonância Magnética , Osteomielite/diagnóstico , Osteomielite/terapia , Coluna Vertebral
9.
Rev Med Liege ; 78(12): 685-688, 2023 Dec.
Artigo em Francês | MEDLINE | ID: mdl-38095031

RESUMO

Infectious epiduritis and epidural abscesses are relatively rare pathologies but with important neurological consequences. A low incidence associated with an insidious clinical presentation leads to frequent delays in diagnosis, which worsen the prognosis of patients with the development of neurological deficits. While the evaluation of risk factors, a careful clinical examination and biological tests can guide to the diagnosis, the key examination remains magnetic resonance imaging (MRI) while lumbar puncture remains contraindicated. Although surgery (spinal decompression) has long been the treatment of choice, the current management of patients with infectious epiduritis is debated between surgery and conservative treatment with systemic antibiotic therapy.


Les épidurites infectieuses et les abcès épiduraux sont des pathologies relativement rares, mais avec des conséquences neurologiques redoutables. Une faible incidence et une présentation clinique souvent insidieuse engendrent de fréquents retards de diagnostic qui péjorent le pronostic des patients avec le développement de déficits neurologiques. Si l'évaluation des facteurs de risque, un examen clinique scrupuleux et des analyses biologiques peuvent guider vers le diagnostic, l'examen-clé reste l'imagerie par résonance magnétique (IRM). La ponction lombaire est contre-indiquée. Bien que l'approche chirurgicale ait longtemps été le traitement de choix, un traitement plus conservateur basé sur une antibiothérapie systémique est également discuté.


Assuntos
Abscesso Epidural , Cervicalgia , Humanos , Abscesso Epidural/complicações , Abscesso Epidural/diagnóstico , Abscesso Epidural/terapia , Imageamento por Ressonância Magnética , Laminectomia , Fatores de Risco
10.
Int J Mycobacteriol ; 12(3): 364-366, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37721246

RESUMO

Spinal epidural abscess (SEA) is a rarest form of spinal infections and is characterized by the presence of pus in the space between the dura mater, and the osseoligamentous confines of the vertebral canal. This can cause spinal injury due to direct compression or local ischemia. The major etiology of SEA is bacterial and tuberculous in endemic regions. The incidence of fungal spinal abscess is relatively low and <5% of SEA is attributable to fungi. We, here, report a case of 77-year-old known patient of chronic renal disease on hemodialysis that presented with low-back pain for 15 days and was subsequently diagnosed with SEA by magnetic resonance imaging, and causative organism was identified as Candida by culture. The abscess was surgically drained after laminectomy. The patient improved with surgery and antifungal treatment.


Assuntos
Abscesso Epidural , Coluna Vertebral , Humanos , Idoso , Coluna Vertebral/diagnóstico por imagem , Abscesso Epidural/diagnóstico , Abscesso Epidural/microbiologia , Abscesso Epidural/cirurgia , Laminectomia , Imageamento por Ressonância Magnética
11.
World Neurosurg ; 180: 77-78, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37741329

RESUMO

Spinal epidural abscesses (SEA) require prompt diagnosis to avoid devastating consequences. Here, we discuss the case of a healthy 20-year-old college student-with a recent diagnosis of strep pharyngitis-who presented with neck pain, fever, and a neurologic deficit-the most common symptoms of SEA. Magnetic resonance imaging revealed a T1-postcontrast, peripherally enhancing epidural collection from C3-T5 with associated cord compression and T3 osteomyelitis. The patient was treated with emergent skip hemilaminectomies for abscess evacuation. Surgical cultures grew Fusobacterium necrophorum, a highly unusual pathogen in SEA. It is an oral anaerobe that translocated through the mucosa in the setting of strep pharyngitis. We treated the patient with ceftriaxone for 6 weeks. The patient had a full neurologic recovery and remains without recurrence of infection 11 months postoperatively. Healthy patients without obvious risk factors may present with SEA, highlighting the need for atypical cases such as these to be brought to clinicians' attention.


Assuntos
Abscesso Epidural , Faringite , Compressão da Medula Espinal , Humanos , Adulto Jovem , Adulto , Abscesso Epidural/complicações , Abscesso Epidural/diagnóstico por imagem , Abscesso Epidural/cirurgia , Laminectomia , Imageamento por Ressonância Magnética , Compressão da Medula Espinal/cirurgia , Faringite/cirurgia , Faringite/complicações
12.
BMJ Case Rep ; 16(7)2023 Jul 17.
Artigo em Inglês | MEDLINE | ID: mdl-37460247

RESUMO

Patients with Lemierre's syndrome may have complications such as lung lesions, large joint arthritis and central nervous system involvement. However, complications involving a pterygoid abscess have scarcely been reported. Here, we report a case of bilateral Lemierre's syndrome accompanied with an intracranial epidural abscess and bilateral pterygoid abscesses. A woman in her 70s presented to the emergency room with a decreased level of consciousness. Infection was suspected, and Slackia exigua and species of Fusobacterium were identified in blood cultures, which suggested that the origin of infection was odontogenic, particularly as the patient had poor oral hygiene. Head and neck CT with contrast enhancement revealed bilateral internal jugular vein thrombophlebitis, septic pulmonary embolism, frontal epidural abscess and bilateral pterygoid abscesses. After antibiotic treatment and drainage, her condition improved. Pterygoid abscesses should be recognised as a rare complication of Lemierre's syndrome, especially when the infection origin is odontogenic.


Assuntos
Abscesso Epidural , Síndrome de Lemierre , Tromboflebite , Feminino , Humanos , Síndrome de Lemierre/diagnóstico , Síndrome de Lemierre/diagnóstico por imagem , Fusobacterium necrophorum , Tromboflebite/tratamento farmacológico , Antibacterianos/uso terapêutico , Abscesso Epidural/complicações , Abscesso Epidural/diagnóstico por imagem , Abscesso Epidural/tratamento farmacológico , Veias Jugulares/microbiologia
13.
BMC Musculoskelet Disord ; 24(1): 586, 2023 Jul 18.
Artigo em Inglês | MEDLINE | ID: mdl-37464374

RESUMO

BACKGROUND: Pyogenic spondylitis is a condition with low incidence that can lead to neurological sequelae and even life-threatening conditions. While conservative methods, including antibiotics and bracing, are considered the first-line treatment option for pyogenic spondylitis, it is important to identify patients who require early surgical intervention to prevent progressive neurologic deficits or deterioration of the systemic condition. Surgical treatment should be considered in patients with progressive neurologic deficits or deteriorating systemic condition. However, currently, there is a lack of treatment guidelines, particularly with respect to whether surgical treatment is necessary for pyogenic spondylitis. This study aims to analyze the radiological epidural abscess on MRI and clinical factors to predict the need for early surgical intervention in patients with pyogenic spondylitis and provide comprehensive insight into the necessity of early surgical intervention in these patients. METHODS: This study retrospectively reviewed 47 patients with pyogenic spondylitis including spondylodiscitis, vertebral osteomyelitis, epidural abscess, and/or psoas abscess. All patients received plain radiographs, and a gadolinium-enhanced magnetic resonance imaging (MRI) scan. All patients have either tissue biopsies and/or blood cultures for the diagnosis of a pathogen. Demographic data, laboratory tests, and clinical predisposing factors including comorbidities and concurrent other infections were analyzed. RESULTS: We analyzed 47 patients, 25 of whom were female, with a mean age of 70,7 years. MRI revealed that 26 of 47 patients had epidural abscesses. The surgical group had a significantly higher incidence of epidural abscess than the non-surgical group (p = 0.001). In addition, both CRP and initial body temperature (BT) were substantially higher in the surgical group compared to the non-surgical group. There was no significant difference between the surgical group and the non-surgical group in terms of age, gender, comorbidities, and concurrent infectious disorders, as well as the number of affected segments and affected spine levels. However, the surgical group had lengthier hospital stays and received more antibiotics. CONCLUSION: The presence of an epidural abscess on MRI should be regarded crucial in the decision-making process for early surgical treatment in patients with pyogenic spondylitis in order to improve clinical outcomes.


Assuntos
Abscesso Epidural , Espondilartrite , Espondilite , Humanos , Feminino , Masculino , Abscesso Epidural/diagnóstico por imagem , Abscesso Epidural/cirurgia , Abscesso Epidural/complicações , Estudos Retrospectivos , Espondilite/diagnóstico por imagem , Espondilite/cirurgia , Imageamento por Ressonância Magnética/efeitos adversos , Antibacterianos/uso terapêutico
16.
Childs Nerv Syst ; 39(12): 3561-3570, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37368066

RESUMO

INTRODUCTION: Intracranial infection is often associated with contiguous sinus infection, with Streptococcus intermedius being the most common pathogen. Microbiological assessment is possible via sinus or intracranial sampling. While a sinus approach is minimally invasive, it is not clear whether this yields definitive microbiological diagnosis leading to optimized antimicrobial therapy and avoidance of intracranial surgery. METHODS: A retrospective review of a prospectively collected electronic departmental database identified patients between 2019 and 2022. Further demographic and microbiological information was obtained from electronic patient records and laboratory management systems. RESULTS: Thirty-one patients were identified with intracranial subdural and/or epidural empyema and concurrent sinus involvement during the 3-year study period. The median age of onset was 10 years with a slight male predominance (55%). All patients had intracranial sampling with 15 patients undergoing sinus sampling in addition. Only 1 patient (7%) demonstrated identical organism(s) grown from both samples. Streptococcus intermedius was the most common pathogen in intracranial samples. Thirteen patients (42%) had mixed organisms from their intracranial cultures and 57% of samples undergoing bacterial PCR identified additional organisms, predominantly anaerobes. Sinus samples had a significant addition of nasal flora and Staphylococcus aureus which was rarely grown from intracranial samples. Of concern, 7/14 (50%) of sinus samples did not identify the main intracranial pathogen diagnosed on intracranial culture and additional PCR. Literature review identified 21 studies where sinus drainage was used to treat intracranial empyemas, with only 6 authors reporting concurrent microbiology results. This confirmed our cohort to be the largest comparative study in the current literature. No center has observed a greater than 50% concordance in microbiological diagnoses. CONCLUSION: Endoscopic sinus surgery may have therapeutic benefit, but it is not an appropriate approach for microbiological diagnosis in pediatric subdural empyemas. High rates of contaminating nasal flora can lead to misdiagnosis and inappropriate treatment. Routine addition of 16S rRNA PCR to intracranial samples is recommended.


Assuntos
Empiema Subdural , Abscesso Epidural , Seios Paranasais , Sinusite , Criança , Feminino , Humanos , Masculino , Empiema Subdural/diagnóstico , Empiema Subdural/microbiologia , Abscesso Epidural/complicações , Estudos Retrospectivos , RNA Ribossômico 16S , Sinusite/complicações
17.
Neurol India ; 71(2): 331-333, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37148064

RESUMO

Spinal epidural abscess (SEA) is a very serious infection of the central nervous system (CNS). It is of very low incidence with a peak age in the geriatric age group. Immunocompromised patients are more susceptible to SEA. It can present with significant neurological deficits, which can be permanent if not identified and treated promptly. In this case report, a 75-year-old immunocompromised patient presented with progressive spastic quadriparesis and septicemia. He was diagnosed with a case of cervical spinal epidural abscess with underlying cord compression. Anterior retropharyngeal approach and button-hole disco-osteotomy of C5-C6 was performed and the cervical SEA was drained, followed by antibiotic saline irrigation (cranially and caudally) was done, total duration of surgery was 70 min. At the time of discharge (7th postoperative day), the patient improved neurologically and sepsis had resolved.


Assuntos
Abscesso Epidural , Masculino , Humanos , Idoso , Abscesso Epidural/complicações , Abscesso Epidural/cirurgia , Abscesso Epidural/diagnóstico , Coluna Vertebral/cirurgia , Antibacterianos/uso terapêutico , Osteotomia , Drenagem
18.
Medicine (Baltimore) ; 102(19): e33745, 2023 May 12.
Artigo em Inglês | MEDLINE | ID: mdl-37171345

RESUMO

RATIONALE: Postoperative intracranial mycoplasma hominis infection was a rare complication. Timely diagnosis was difficult due to its growth characteristics and nonspecific clinical symptoms. PATIENT CONCERNS: A 52-year-old man underwent bilateral decompressive craniotomy for severe traumatic brain injury. On the seventeenth day after surgery, the patient developed an unexplained high fever. Empirical anti-infective therapy was ineffective, and the fever persisted. In addition, viscous pus oozed from the head incision. Empiric therapy was still ineffective, the fever persisted, and the culture result was negative. The lumbar puncture pressure was 150 mmH2O and the cerebrospinal fluid white blood cell count was 3600 × 106/L, suggesting an intracranial infection. DIAGNOSES: Culture growth morphologically consistent with mycoplasma species was obtained from multiple specimens (scalp incision fluid and cerebrospinal fluid) and the identification of mycoplasma hominis was confirmed by 16S rDNA sequencing. INTERVENTION: Targeted anti-infective therapy (Minocycline), change of fresh wound dressing, and continued lumbar cerebrospinal fluid drainage. OUTCOME: At the 3-month follow-up, the patient was still in the rehabilitation department of the local hospital for treatment, but there were no symptoms of intracranial infection. LESSONS: Neurosurgeons should carefully examine postoperative incisions and be aware of the possibility of mycoplasma infection during clinical management.


Assuntos
Craniectomia Descompressiva , Empiema , Abscesso Epidural , Meningite , Infecções por Mycoplasma , Ferida Cirúrgica , Masculino , Humanos , Pessoa de Meia-Idade , Mycoplasma hominis , Craniectomia Descompressiva/efeitos adversos , Complicações Pós-Operatórias/etiologia , Abscesso Epidural/cirurgia , Abscesso Epidural/complicações , Infecções por Mycoplasma/diagnóstico , Ferida Cirúrgica/complicações , Empiema/complicações , Craniotomia/efeitos adversos
20.
J Neurosurg Spine ; 39(3): 419-426, 2023 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-37243554

RESUMO

OBJECTIVE: Vertebral osteomyelitis is a rare complication of coccidioidomycosis infection. Surgical intervention is indicated when there is failure of medical management or presence of neurological deficit, epidural abscess, or spinal instability. The relationship between timing of surgical intervention and recovery of neurological function has not been previously described. The purpose of this study was to investigate if the duration of neurological deficits at presentation affects neurological recovery after surgical intervention. METHODS: This was a retrospective study of all patients diagnosed with coccidioidomycosis involving the spine at a single tertiary care center between 2012 and 2021. Data collected included patient demographics, clinical presentation, radiographic information, and surgical intervention. The primary outcome was change in neurological examination after surgical intervention, quantified according to the American Spinal Injury Association Impairment Scale. The secondary outcome was the complication rate. Logistic regression was used to test if the duration of neurological deficits was associated with improvement in the neurological examination after surgery. RESULTS: Twenty-seven patients presented with spinal coccidioidomycosis between 2012 and 2021; 20 of these patients had vertebral involvement on spinal imaging with a median follow-up of 8.7 months (IQR 1.7-71.2 months). Of the 20 patients with vertebral involvement, 12 (60.0%) presented with a neurological deficit with a median duration of 20 days (range 1-61 days). Most patients presenting with neurological deficit (11/12, 91.7%) underwent surgical intervention. Nine (81.2%) of these 11 patients had an improved neurological examination after surgery and the other 2 had stable deficits. Seven patients had improved recovery sufficient to improve by 1 grade according to the AIS. The duration of neurological deficits on presentation was not significantly associated with neurological improvement after surgery (p = 0.49, Fisher's exact test). CONCLUSIONS: The duration of neurological deficits on presentation should not deter surgeons from operative intervention in cases of spinal coccidioidomycosis.


Assuntos
Coccidioidomicose , Abscesso Epidural , Doenças da Coluna Vertebral , Humanos , Coccidioidomicose/diagnóstico por imagem , Coccidioidomicose/cirurgia , Estudos Retrospectivos , Coluna Vertebral/cirurgia , Abscesso Epidural/diagnóstico , Abscesso Epidural/cirurgia
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